アメリカ心臓協会（AHA）

日本心臓病学会

日本臨床検査医学会

日本心臓リハビリテーション学会

日本肺高血圧・肺循環学会

日本腎臓学会

日本腎臓リハビリテーション学会

日本心不全学会

日本動脈硬化学会

日本血栓止血学会

CHA2DS2-VASc and HAS-BLED scores and activated partial thromboplastin time for prediction of high plasma concentration of dabigatran at trough.

Shingen Owada, Hirofumi Tomita, Takahiko Kinjo, Yuji Ishida, Taihei Itoh, Kenichi Sasaki, Daisuke Horiuchi, Masaomi Kimura, Shingo Sasaki, Ken Okumura

Thrombosis research   135 ( 1 )   62 - 67   2015年01月

Coronary vasospasm induced in transgenic mouse with increased phospholipase C-δ1 activity.

Shuji Shibutani, Tomohiro Osanai, Toshihiro Ashitate, Shigeki Sagara, Kei Izumiyama, Yuko Yamamoto, Kenji Hanada, Takashi Echizen, Hirofumi Tomita, Takeshi Fujita, Takeshi Miwa, Hiroaki Matsubara, Yoshimi Homma, Ken Okumura

Circulation   125 ( 8 )   1027 - 1036   2012年02月

Aortic arch curvature and atherosclerosis have overlapping quantitative trait loci in a cross between 129S6/SvEvTac and C57BL/6J apolipoprotein E-null mice.

Hirofumi Tomita, Svetlana Zhilicheva, Shinja Kim, Nobuyo Maeda

Circulation research   106 ( 6 )   1052 - 1060   2010年04月

A Novel Risk Stratification System for Ischemic Stroke in Japanese Patients With Non-Valvular Atrial Fibrillation

Okumura Ken, Tomita Hirofumi, Nakai Michikazu, Kodani Eitaro, Akao Masaharu, Suzuki Shinya, Hayashi Kenshi, Sawano Mitsuaki, Goya Masahiko, Yamashita Takeshi, Fukuda Keiichi, Ogawa Hisashi, Tsuda Toyonobu, Isobe Mitsuaki, Toyoda Kazunori, Miyamoto Yoshihiro, Miyata Hiroaki, Okamura Tomonori, Sasahara Yusuke, Goya Masahiko

Circulation Journal   85 ( 8 )   1254 - 1262   2021年07月

Comparison of procedural and clinical outcomes between optical coherence tomography and intravascular ultrasound guided percutaneous coronary intervention for patients with acute coronary syndrome

Shun Shikanai, Takashi Yokota, Hiroaki Yokoyama, Takanobu Soma, Shuntaro Sakai, Yuya Sorimachi, Shogo Hamaura, Ken Yamazaki, Michiko Tsushima, Maiko Senoo, Hiroaki Ichikawa, Fumie Nishizaki, Shuji Shibutani, Kenji Hanada, Hirofumi Tomita

74   6 - 16   2024年03月

Impact of factor Xa inhibitors on outcomes of atrial tachyarrhythmia recurrence following catheter ablation for atrial fibrillation: comparison with warfarin

Shota Washima, Shogo Hamaura, Yuichi Toyama, Kimitaka Nishizaki, Takahiko Kinjo, Yuji Ishida, Taihei Itoh, Masaomi Kimura, Shingo Sasaki, Kazumasa Saito, Takanobu Soma, Hirofumi Tomita

74   87 - 98   2024年03月

Clinical Benefits of Oral Anticoagulants for Elderly Patients With Cardioembolic Stroke at High Bleeding Risk.

Saito K, Hagii J, Soma T, Washima S, Yamada N, Shiroto H, Saito S, Kamada T, Takanashi S, Tomita H

In vivo (Athens, Greece)   38 ( 2 )   725 - 733   2024年03月

Incidence of postoperative cytomegalovirus and BK-polyoma virus infections and graft loss in ABO-incompatible renal transplant recipients: a multicenter retrospective study.

Kodama H, Hatakeyama S, Matsuura T, Saito M, Nishida H, Hamaya T, Maita S, Murakami R, Tomita H, Saitoh H, Tsuchiya N, Habuchi T, Obara W, Ohyama C

International urology and nephrology   2024年02月

Role of G-protein-coupled estrogen receptor in the pathogenesis of chronic asthma.

Itoga M, Ishioka Y, Makiguchi T, Tanaka H, Taima K, Saito N, Tomita H, Tasaka S

Immunology letters   265   16 - 22   2024年02月

Dual tachyarrhythmia: Ventricular fibrillation induced by atrial tachyarrhythmia in a patient with hypertrophic cardiomyopathy.

Kinjo T, Sasaki S, Horiuchi D, Ishida Y, Tomita H

Journal of arrhythmia   40 ( 1 )   180 - 183   2024年02月

Prognostic Impact of Acute Myocardial Infarction-Related Ventricular Tachyarrhythmia in the Current Era　- Reply.

Hanada K, Tomita H

Circulation journal : official journal of the Japanese Circulation Society   88 ( 2 )   262   2024年01月

Multiple Blood Culture Sampling, Proper Antimicrobial Choice, and Adequate Dose in Definitive Therapy Supported by the Antimicrobial Stewardship Team Could Decrease 30-Day Sepsis Mortality Rates.

Saito N, Tsuchiya J, Itoga M, Okamura Y, Tsuyama H, Kimura M, Inoue F, Kimura T, Ozaki H, Tono Y, Minakawa S, Tomita H

Infection and drug resistance   17   207 - 219   2024年01月

Posterior wall thickness of the confluent inferior pulmonary veins measured by left atrial intracardiac echocardiography: implications for catheter ablation.

Negishi K, Okumura K, Onishi F, Yoshimura A, Okamatsu H, Tsurugi T, Tanaka Y, Sakai Y, Nakao K, Sakamoto T, Koyama J, Tomita H

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   67 ( 1 )   193 - 201   2024年01月

Serial longitudinal changes of coronary calcified plaques with clear outer borders under intensive lipid management: insights from optical coherence tomography.

Soma T, Yokoyama H, Saito K, Washima S, Tsushima M, Senoo M, Ichikawa H, Nishizaki F, Shibutani S, Hanada K, Tomita H

Heart and vessels   2023年12月

Impact of Multilevel Atrioventricular Block on Verapamil-Sensitive Idiopathic Left Ventricular Tachycardia Alongside Typical Atrial Flutter.

Itoh T, Nishizaki K, Kimura M, Tomita H

JACC. Clinical electrophysiology   2023年12月

Landiolol, an intravenous β1-selective blocker, is useful for dissociating a fusion of atrial activation via accessory pathway and atrioventricular node.

Kinjo T, Kimura M, Kaname N, Horiuchi D, Itoh T, Ishida Y, Nishizaki K, Toyama Y, Sasaki S, Tomita H

Journal of arrhythmia   39 ( 6 )   937 - 946   2023年12月

Impact of timing of rejection episode on cardiovascular events in living donor kidney transplantation: a multicenter retrospective study.

Okamoto T, Hatakeyama S, Hamaya T, Matsuura T, Saito M, Nishida H, Maita S, Murakami R, Tomita H, Saitoh H, Tsuchiya N, Habuchi T, Obara W, Ohyama C

Journal of nephrology   36 ( 9 )   2613 - 2620   2023年12月

Serum 3-Hydroxybutyrate is Expected to Serve as One of the Supportive Diagnostic Markers of Persistent Idiopathic Dentoalveolar Pain (PDAP).

Tamaki K, Saito N, Tomita H

Journal of pain research   16   4005 - 4013   2023年11月

Hypoxia-inducible Factor-1α Suppresses the Innate Immune Response in Cultured Human Proximal Tubular Cells.

Nagawa D, Shimada M, Nakata M, Narita-Kinjo I, Fujita T, Murakami R, Nakamura N, Tomita H

In vivo (Athens, Greece)   37 ( 6 )   2437 - 2446   2023年11月

Incidence, Predictors, and Outcome Associated With Ventricular Tachycardia or Fibrillation in Patients Undergoing Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction.

Hanada K, Kinjo T, Yokoyama H, Tsushima M, Senoo M, Ichikawa H, Nishizaki F, Shibutani S, Yokota T, Okumura K, Tomita H

Circulation journal : official journal of the Japanese Circulation Society   2023年09月

Humoral response to SARS-CoV-2 mRNA vaccine on in ABO blood type incompatible kidney transplant recipients treated with low-dose rituximab.

Hamaya T, Hatakeyama S, Yoneyama T, Tobisawa Y, Kodama H, Fujita T, Murakami R, Mori K, Okamoto T, Yamamoto H, Yoneyama T, Hashimoto Y, Saitoh H, Narumi S, Tomita H, Ohyama C

Scientific reports   13 ( 1 )   15098   2023年09月

Long RP Tachycardia With Simple vs Complex Bypass Tracts.

Itoh T, Kimura M, Nishizaki K, Ishida Y, Tomita H

JACC. Clinical electrophysiology   9 ( 8 Pt 1 )   1421 - 1427   2023年08月

Dietary Intake of Polyunsaturated Fatty Acids and Diabetic Nephropathy: Cohort Analysis of the Tsugaru Study.

Nakamura N, Nagawa D, Nakata M, Narita-Kinjo I, Fujita T, Murakami R, Shimada M, Okita A, Sekino K, Tazawa A, Tomita H

In vivo (Athens, Greece)   37 ( 4 )   1890 - 1893   2023年07月

Great cardiac vein occlusion following radiofrequency catheter ablation: a late complication identified during cardiac device implantation.

Kinjo T, Sasaki S, Kimura M, Tomita H

European heart journal. Cardiovascular Imaging   24 ( 7 )   e115   2023年06月

Use of a QDOT MICRO catheter to identify a premature ventricular contraction origin in the right ventricular anterior papillary muscle in a repaired truncus arteriosus.

Itoh T, Ishida Y, Kimura M, Tomita H

Pacing and clinical electrophysiology : PACE   2023年06月

Effect of problem-based learning tutor seniority on medical students' emotions: an equivalence study.

Nomura O, Abe T, Soma Y, Tomita H, Kijima H

BMC medical education   23 ( 1 )   419   2023年06月

Valacyclovir-associated acute kidney injury and encephalopathy in an elderly woman with normal kidney function: a case report.

Kato K, Murakami R, Shiroto H, Nagawa D, Narita-Kinjo I, Fujita T, Shimada M, Tomita H

CEN case reports   2023年05月

Relationship Between Cardiovascular Events and Serum Lipid and Plasma Fatty Acid Profile in Maintenance Hemodialysis Patients With Diabetic Mellitus.

Nakamura N, Osawa H, Nagawa D, Nakata M, Narita-Kinjo I, Fujita T, Murakami R, Shimada M, Tomita H, Tsutaya C, Saito H, Suzuki T

In vivo (Athens, Greece)   37 ( 3 )   1182 - 1185   2023年05月

Incidental Imminent Rupture of the Left Ventricular Pseudo-aneurysm.

Kimura Y, Yokoyama H, Minakawa M, Tomita H

Internal medicine (Tokyo, Japan)   2023年04月

Demonstration of presence of a sling between anterior and posterior bundle branch during tachycardia using twin atrioventricular nodes: A case of asplenia syndrome.

Kinjo T, Kimura M, Itoh T, Ishida Y, Tomita H

HeartRhythm case reports   9 ( 4 )   248 - 252   2023年04月

Effect of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of rivaroxaban and edoxaban in patients with nonvalvular atrial fibrillation.

Nakagawa J, Kinjo T, Aiuchi N, Ueno K, Tomita H, Niioka T

European journal of clinical pharmacology   2023年03月

Low Creatinine Clearance Is a Risk Factor for Severe Cardioembolic Stroke in Japanese Female Patients.

Sakai S, Hagii J, Shikanai S, Sorimachi Y, Hamaura S, Yamazaki K, Yamada N, Shiroto H, Saito S, Kamada T, Takanashi S, Okumura K, Tomita H

In vivo (Athens, Greece)   37 ( 1 )   336 - 344   2023年01月

Impacts of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of apixaban in patients with non-valvular atrial fibrillation.

Nakagawa J, Kinjo T, Aiuchi N, Ueno K, Tomita H, Niioka T

79 ( 1 )   127 - 135   2022年12月

Impact of baseline blood pressure on adverse outcomes in Japanese patients with non-valvular atrial fibrillation: the J-RISK AF.

Kodani E, Tomita H, Nakai M, Akao M, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Ogawa H, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Miyata H, Okamura T, Sasahara Y, Okumura K, J-RISK AF Research Group

European heart journal open   2 ( 6 )   oeac081   2022年11月

Characterization of the PRAETORIAN score in Japanese patients undergoing subcutaneous implantable cardioverter-defibrillator implantation.

Yamazaki K, Ishida Y, Sasaki S, Toyama Y, Nishizaki K, Kinjo T, Itoh T, Kimura M, Sakai S, Shikanai S, Sorimachi Y, Hamaura S, Tomita H

Journal of cardiology   80 ( 5 )   482 - 486   2022年11月

Associations among plasma concentrations of edoxaban and M-4, prothrombin time, and the SLCO1B1*15 haplotype in patients with non-valvular atrial fibrillation.

Nakagawa J, Kinjo T, Aiuchi N, Ueno K, Tomita H, Niioka T

Therapeutic drug monitoring   2022年09月

Answer: Incessant wide QRS complex tachycardia refractory to amiodarone.

Itoh T, Ishida Y, Tomita H

European heart journal. Acute cardiovascular care   11 ( 7 )   e3 - e4   2022年07月

Question: Incessant wide QRS complex tachycardia refractory to amiodarone.

Itoh T, Ishida Y, Tomita H

European heart journal. Acute cardiovascular care   2022年07月

Prognostic Impact of Diabetes Mellitus on Clinical Outcomes in Lean Patients With Acute Myocardial Infarction.

Hamadate M, Yokoyama H, Sakai S, Shikanai S, Sorimachi Y, Yamazaki K, Kitayama K, Miura N, Yokota T, Tomita H

In vivo (Athens, Greece)   36 ( 3 )   1383 - 1390   2022年05月

Seroprevalence of SARS-CoV-2 spike IgG antibodies after the second BNT162b2 mRNA vaccine in Japanese kidney transplant recipients.

Hamaya T, Hatakeyama S, Yoneyama T, Tobisawa Y, Kodama H, Fujita T, Murakami R, Fujita N, Okamoto T, Yamamoto H, Yoneyama T, Hashimoto Y, Saitoh H, Narumi S, Tomita H, Ohyama C

Scientific reports   12 ( 1 )   5876   2022年04月

The usefulness of balloon occlusive left ventricular lead delivery in combination with the quadripolar active fixation lead for a patient with complex coronary venous morphology.

Sasaki S, Kaname N, Kinjo T, Tomita H

Journal of cardiology cases   25 ( 4 )   225 - 228   2022年04月

Reduced Left Ventricular Ejection Fraction Is a Risk for Sudden Cardiac Death in the Early Period After Hospital Discharge in Patients With Acute Myocardial Infarction.

Hanada K, Sasaki S, Seno M, Kimura Y, Ichikawa H, Nishizaki F, Yokoyama H, Yokota T, Okumura K, Tomita H

Circulation journal : official journal of the Japanese Circulation Society   2022年03月

Inducible Systemic <i>Gcn1</i> Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage.

Liu J, Kasai S, Tatara Y, Yamazaki H, Mimura J, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Tanji K, Wakabayashi K, Maeda H, Mizukami H, Shinkai Y, Kumagai Y, Tomita H, Itoh K

International journal of molecular sciences   23 ( 6 )   2022年03月

Frequent supraventricular premature contractions are an independent predictor for detection of atrial fibrillation in patients with embolic stroke undetermined source

Kazutaka Kitayama, Shin Saito, Misato Hamadate, Naotake Miura, Natsumi Yamada, Hiroshi Shiroto, Norifumi Metoki, Joji Hagii, Takaatsu Kamada, Shingo Takanashi, Hirofumi Tomita

2022年03月

Mosaic activation pattern demonstrated by high-resolution mapping during double atrial tachycardia.

Nishizaki K, Itoh T, Kimura M, Tomita H

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   2022年03月

Prolongation of a short stimulus-to-atrial interval during para-Hisian pacing: What is the mechanism?

Itoh T, Kimura M, Toyama Y, Hamaura S, Tomita H

Pacing and clinical electrophysiology : PACE   45 ( 3 )   418 - 420   2022年03月

Substernal and subcutaneous electrocardiograms during subcutaneous implantable cardioverter-defibrillator implantation.

Ishida Y, Itoh T, Sasaki S, Washima S, Toyama Y, Tomita H

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   2022年02月

Successful bailout from the entrapment of self-expanding transcatheter aortic valve system caused by the under-expanded deployed valve.

Yokoyama H, Saito Y, Senoo M, Yokota T, Tobaru T, Tomita H

Cardiovascular intervention and therapeutics   2022年02月

Catheter-based ultrasound renal denervation in patients with resistant hypertension: the randomized, controlled REQUIRE trial.

Kario K, Yokoi Y, Okamura K, Fujihara M, Ogoyama Y, Yamamoto E, Urata H, Cho JM, Kim CJ, Choi SH, Shinohara K, Mukai Y, Ikemoto T, Nakamura M, Seki S, Matoba S, Shibata Y, Sugawara S, Yumoto K, Tamura K, Yoshihara F, Nakamura S, Kang WC, Shibasaki T, Dote K, Yokoi H, Matsuo A, Fujita H, Takahashi T, Kang HJ, Sakata Y, Horie K, Inoue N, Sasaki KI, Ueno T, Tomita H, Morino Y, Nojima Y, Kim CJ, Matsumoto T, Kai H, Nanto S

Hypertension research : official journal of the Japanese Society of Hypertension   45 ( 2 )   221 - 231   2022年02月

Contrast injection into the right atrial appendage apex using an external irrigation catheter for focal atrial tachycardia ablation.

Nishizaki K, Itoh T, Kimura M, Tomita H

Journal of arrhythmia   38 ( 1 )   157 - 159   2022年02月

Enhanced β-adrenergic response in mice with dominant-negative expression of the PKD2L1 channel.

Murakami M, Murakami AM, Nemoto T, Ohba T, Yonekura M, Toyama Y, Tomita H, Matsuzaki Y, Sawamura D, Hirota K, Itagaki S, Asada Y, Miyoshi I

PloS one   17 ( 1 )   e0261668   2022年01月

経カテーテル的大動脈弁留置術中の経食道心エコーにて乳頭状線維弾性腫が疑われた2症例

酒井峻太郎, 横山公章, 市川博章, 木村嘉宏, 西崎史恵, 花田賢二, 横田貴志, 山田雅大, 富田泰史

心臓   54 ( 1 )   100 - 105   2022年01月

Effect of Low Body Mass Index on the Clinical Outcomes of Japanese Patients With Acute Myocardial Infarction　- Results From the Prospective Japan Acute Myocardial Infarction Registry (JAMIR).

Yokoyama H, Tomita H, Honda S, Nishihira K, Kojima S, Takegami M, Asaumi Y, Yamashita J, Saji M, Kosuge M, Takahashi J, Sakata Y, Takayama M, Sumiyoshi T, Ogawa H, Kimura K, Yasuda S, JAMIR Investigators.

Circulation journal : official journal of the Japanese Circulation Society   2021年11月

Multiple exit sites identification by pace mapping with a grid catheter: Which bipolar pairs are in the critical ventricular tachycardia isthmus?

Itoh T, Kimura M, Ishida Y, Tomita H

HeartRhythm case reports   7 ( 11 )   776 - 779   2021年11月

Diltiazem Inhibits Coronary Spasm via Inhibition of Cav1.2Phosphorylation and Protein Kinase C Activation in a Mouse Model of Coronary Spastic Angina

Ishida Yuji, Nishizaki Fumie, Sukekawa Takanori, Tanaka Makoto, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi, Kitayama Kazutaka, Hanada Kenji, Shibutani Shuji, Nishizaki Kimitaka, Kinjo Takahiko, Endo Tomohide, Suzuki Akiko, Tateyama Shunta

International Heart Journal   62 ( 4 )   910 - 918   2021年07月

Rivaroxaban attenuates cardiac hypertrophy by inhibiting protease-activated receptor-2 signaling in renin-overexpressing hypertensive mice.

Narita M, Hanada K, Kawamura Y, Ichikawa H, Sakai S, Yokono Y, Senoo M, Narita N, Shimada M, Osanai T, Okumura K, Tomita H

Hypertension research : official journal of the Japanese Society of Hypertension   2021年07月

内科的治療で心嚢液の減少を認めた原発性乳糜心膜症の1例

酒井峻太郎, 西崎史恵, 芦立俊宗, 遠藤知秀, 澁谷修司, 花田賢二, 横山公章, 横田貴志, 山田雅大, 掛端伸也, 福田幾夫, 富田泰史

心臓   53 ( 7 )   737 - 742   2021年07月

Nintedanib-Induced Renal Thrombotic Microangiopathy.

Fujita T, Nakagawa H, Yokota T, Umetani J, Nagawa D, Nakata M, Narita-Kinjo I, Murakami R, Shimada M, Nakamura N, Tomita H

Case reports in nephrology and dialysis   11 ( 2 )   227 - 232   2021年05月

Double tachycardia with His-left ventricular and interventricular dissociations.

Itoh T, Kimura M, Tomita H

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology   2021年04月

Persistent or permanent atrial fibrillation is associated with severe cardioembolic stroke in patients with non-valvular atrial fibrillation.

Hagii J, Metoki N, Saito S, Shiroto H, Sasaki S, Takahashi K, Hitomi H, Baba Y, Yamada N, Seino S, Kamada T, Uchizawa T, Nakamura T, Yasujima M, Tomita H

Thrombosis journal   19 ( 1 )   22   2021年03月

Giant left atrial calcified myxoma-induced premature atrial contractions.

Shun Shikanai, Taihei Itoh, Hirofumi Tomita

23 ( 2 )   183 - 183   2021年02月

Giant left atrial calcified myxoma-induced premature atrial contractions.

Shikanai S, Itoh T, Tomita H

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology   23 ( 2 )   183   2021年02月

Impact of gene polymorphisms in drug-metabolizing enzymes and transporters on trough concentrations of rivaroxaban in patients with atrial fibrillation.

Junichi Nakagawa, Takahiko Kinjo, Mei Iizuka, Kayo Ueno, Hirofumi Tomita, Takenori Niioka

128 ( 2 )   297 - 304   2021年02月

Impact of gene polymorphisms in drug-metabolizing enzymes and transporters on trough concentrations of rivaroxaban in patients with atrial fibrillation.

Nakagawa J, Kinjo T, Iizuka M, Ueno K, Tomita H, Niioka T

Basic & clinical pharmacology & toxicology   128 ( 2 )   297 - 304   2021年02月

Towards Further Development of a Quality Improvement System for Stroke Practice in Japan.

Hirofumi Tomita

Circulation journal : official journal of the Japanese Circulation Society   85 ( 2 )   210 - 212   2021年01月

Towards Further Development of a Quality Improvement System for Stroke Practice in Japan.

Tomita H

Circulation journal : official journal of the Japanese Circulation Society   85 ( 2 )   210 - 212   2021年01月

Clinical impact of complete atrioventricular block in patients with ST-segment elevation myocardial infarction.

Yosuke Kawamura, Hiroaki Yokoyama, Kazutaka Kitayama, Naotake Miura, Misato Hamadate, Daiki Nagawa, Masashi Nozaka, Masamichi Nakata, Fumie Nishizaki, Kenji Hanada, Takashi Yokota, Masahiro Yamada, Takumi Higuma, Hirofumi Tomita

Clinical cardiology   44 ( 1 )   91 - 99   2021年01月

PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes.

Masamichi Nakata, Michiko Shimada, Ikuyo Narita-Kinjo, Daiki Nagawa, Kazutaka Kitayama, Misato Hamadate, Naotake Miura, Masashi Nozaka, Yosuke Kawamura, Takeshi Fujita, Reiichi Murakami, Tadaatsu Imaizumi, Norio Nakamura, Hirofumi Tomita

In vivo (Athens, Greece)   35 ( 1 )   147 - 153   2021年01月

PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes.

Nakata M, Shimada M, Narita-Kinjo I, Nagawa D, Kitayama K, Hamadate M, Miura N, Nozaka M, Kawamura Y, Fujita T, Murakami R, Imaizumi T, Nakamura N, Tomita H

In vivo (Athens, Greece)   35 ( 1 )   147 - 153   2021年01月

Clinical impact of complete atrioventricular block in patients with ST-segment elevation myocardial infarction.

Kawamura Y, Yokoyama H, Kitayama K, Miura N, Hamadate M, Nagawa D, Nozaka M, Nakata M, Nishizaki F, Hanada K, Yokota T, Yamada M, Higuma T, Tomita H

Clinical cardiology   44 ( 1 )   91 - 99   2021年01月

Clinical Therapy in Patients with Aborted Sudden Cardiac Death due to Coronary Spasm

Sueda Shozo, Yamamoto Katsuhito, Iwasaki Yoshihiro, Yoshida Ritsu, Nakamura Shigeru, Ogino Yutaka, Kimura Kazuo, Sasai Masahiro, Suzuki Hiroshi, Wakatsuki Tetsuzo, Asajima Hiroshi, Shinohara Tetsuji, Teragawa Hiroki, Ishikawa Tetsunori, Kitamura Kazuo, Oda Tsuyoshi, Nakayama Takashi, Kobayashi Yoshio, Sunada Daiki, Yamaki Masaru, Nishizaki Fumie, Tomita Hirofumi, Takahashi Naohiko, Usuda Kazuo, Fujinaga Hiroyuki, Kuramitsu Shoichi, Ando Kenji, Kiyooka Takahiko, Kadota Kazushige, Ishii Yoshinao, Ohtani Hayato, Maekawa Yuichiro, Taguchi Eiji, Shite Junya, Nakao Koichi, Kobayashi Nobuaki, Seino Yoshihiko, Nakagawa Hitoshi, Saito Yoshihiko, Komuro Issei, Sasaki Yasuhiro, Ikeda Shuntaro, Yamaguchi Osamu, Kakutani Akiyoshi, Shoji Toshihiro, Imanaka Takahiro, Ishihara Masaharu, Ishii Masanobu, Kaikita Koichi, Tsujita Kenichi, Akao Masaharu, Kijima Yoshiyuki, Masuyama Tohru, Miyaji Tsuyoshi

Journal of Coronary Artery Disease   26 ( 4 )   91 - 99   2020年12月

Decreased cardiac pacemaking and attenuated β-adrenergic response in TRIC-A knockout mice.

Manabu Murakami, Yuichi Toyama, Manabu Yonekura, Takayoshi Ohba, Yasushi Matsuzaki, Daisuke Sawamura, Agnieszka M Murakami, Miyuki Nishi, Shirou Itagaki, Hirofumi Tomita, Hiroshi Takeshima

PloS one   15 ( 12 )   e0244254 - e0244254   2020年12月

Placebo-Controlled, Double-Blind Study of Empagliflozin (EMPA) and Implantable Cardioverter-Defibrillator (EMPA-ICD) in Patients with Type 2 Diabetes (T2DM): Rationale and Design.

Shinya Fujiki, Kenichi Iijima, Masaaki Okabe, Shinichi Niwano, Kenichi Tsujita, Shigeto Naito, Kenji Ando, Kengo Kusano, Ritsushi Kato, Junichi Nitta, Tetsuji Miura, Takeshi Mitsuhashi, Kazuomi Kario, Yusuke Kondo, Masaki Ieda, Nobuhisa Hagiwara, Toyoaki Murohara, Kazuyoshi Takahashi, Hirofumi Tomita, Yasuchika Takeishi, Toshihisa Anzai, Wataru Shimizu, Masafumi Watanabe, Yoshihiro Morino, Takeshi Kato, Hiroshi Tada, Yoshihisa Nakagawa, Masafumi Yano, Koji Maemura, Takeshi Kimura, Hisako Yoshida, Keiko Ota, Takahiro Tanaka, Nobutaka Kitamura, Koichi Node, Yoshifusa Aizawa, Ippei Shimizu, Daisuke Izumi, Kazuyuki Ozaki, Tohru Minamino,

Diabetes therapy : research, treatment and education of diabetes and related disorders   11 ( 11 )   2739 - 2755   2020年11月

Clinical Outcomes of Acute Myocardial Infarction Patients With a History of Malignant Tumor.

Masashi Nozaka, Hiroaki Yokoyama, Kazutaka Kitayama, Daiki Nagawa, Misato Hamadate, Naotake Miura, Yosuke Kawamura, Masamichi Nakata, Fumie Nishizaki, Kenji Hanada, Takashi Yokota, Masahiro Yamada, Hirofumi Tomita

In vivo (Athens, Greece)   34 ( 6 )   3589 - 3595   2020年11月

Placebo-Controlled, Double-Blind Study of Empagliflozin (EMPA) and Implantable Cardioverter-Defibrillator (EMPA-ICD) in Patients with Type 2 Diabetes (T2DM): Rationale and Design.

Fujiki S, Iijima K, Okabe M, Niwano S, Tsujita K, Naito S, Ando K, Kusano K, Kato R, Nitta J, Miura T, Mitsuhashi T, Kario K, Kondo Y, Ieda M, Hagiwara N, Murohara T, Takahashi K, Tomita H, Takeishi Y, Anzai T, Shimizu W, Watanabe M, Morino Y, Kato T, Tada H, Nakagawa Y, Yano M, Maemura K, Kimura T, Yoshida H, Ota K, Tanaka T, Kitamura N, Node K, Aizawa Y, Shimizu I, Izumi D, Ozaki K, Minamino T, EMPA-ICD investigators.

Diabetes therapy : research, treatment and education of diabetes and related disorders   11 ( 11 )   2739 - 2755   2020年11月

Clinical Outcomes of Acute Myocardial Infarction Patients With a History of Malignant Tumor.

Nozaka M, Yokoyama H, Kitayama K, Nagawa D, Hamadate M, Miura N, Kawamura Y, Nakata M, Nishizaki F, Hanada K, Yokota T, Yamada M, Tomita H

In vivo (Athens, Greece)   34 ( 6 )   3589 - 3595   2020年11月

Usefulness of lead repositioning to improve subcutaneous electrocardiogram sensing in patients with arrhythmogenic right ventricular cardiomyopathy with subcutaneous implantable cardioverter-defibrillator.

Shingo Sasaki, Kimitaka Nishizaki, Yuji Ishida, Yuichi Toyama, Shogo Hamaura, Hirofumi Tomita

HeartRhythm case reports   6 ( 10 )   786 - 790   2020年10月

Entrainment of a wide QRS complex tachycardia with progressive atrial delay: What is the mechanism?

Taihei Itoh, Masaomi Kimura, Kimitaka Nishizaki, Hirofumi Tomita

Heart rhythm   17 ( 10 )   1793 - 1795   2020年10月

Usefulness of lead repositioning to improve subcutaneous electrocardiogram sensing in patients with arrhythmogenic right ventricular cardiomyopathy with subcutaneous implantable cardioverter-defibrillator.

Sasaki S, Nishizaki K, Ishida Y, Toyama Y, Hamaura S, Tomita H

HeartRhythm case reports   6 ( 10 )   786 - 790   2020年10月

Entrainment of a wide QRS complex tachycardia with progressive atrial delay: What is the mechanism?

Itoh T, Kimura M, Nishizaki K, Tomita H

Heart rhythm   17 ( 10 )   1793 - 1795   2020年10月

Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging.

Sunao Shimizu, Junsei Mimura, Takanori Hasegawa, Eigo Shimizu, Seiya Imoto, Michiko Tsushima, Shuya Kasai, Hiromi Yamazaki, Yusuke Ushida, Hiroyuki Suganuma, Hirofumi Tomita, Masayuki Yamamoto, Shigeyuki Nakaji, Ken Itoh

PloS one   15 ( 8 )   e0236834 - e0236834   2020年08月

N-Terminal Pro-B-Type Natriuretic Peptide as a Risk Biomarker for Stroke in a General Japanese Population.

Tomita H

Journal of atherosclerosis and thrombosis   27 ( 8 )   749 - 750   2020年08月

N-Terminal Pro-B-Type Natriuretic Peptide as a Risk Biomarker for Stroke in a General Japanese Population.

Hirofumi Tomita

Journal of atherosclerosis and thrombosis   27 ( 8 )   749 - 750   2020年08月

Unusual response to overdrive pacing during a postinfarction ventricular tachycardia: What is the mechanism?

Taihei Itoh, Masaomi Kimura, Shogo Hamaura, Kimitaka Nishizaki, Yuji Ishida, Noriyoshi Kaname, Hirofumi Tomita

Journal of cardiovascular electrophysiology   31 ( 8 )   2243 - 2245   2020年08月

Predictive ability of creatinine clearance versus estimated glomerular filtration rate for outcomes in patients with non-valvular atrial fibrillation: Subanalysis of the J-RHYTHM Registry.

Kodani E, Inoue H, Atarashi H, Tomita H, Okumura K, Yamashita T, Origasa H, J-RHYTHM Registry Investigators.

International journal of cardiology. Heart & vasculature   29   100559   2020年08月

Unusual response to overdrive pacing during a postinfarction ventricular tachycardia: What is the mechanism?

Itoh T, Kimura M, Hamaura S, Nishizaki K, Ishida Y, Kaname N, Tomita H

Journal of cardiovascular electrophysiology   31 ( 8 )   2243 - 2245   2020年08月

Peritoneal Dialysis with Marked Pneumoperitoneum.

Norio Nakamura, Masamichi Nakata, Daiki Nagawa, Ikuyo Narita, Takeshi Fujita, Reiichi Murakami, Michiko Shimada, Hirofumi Tomita

Case reports in nephrology   2020   1063219 - 1063219   2020年07月

Survey on attitudes toward brain-dead and living donor transplantation in medical students: a cross-sectional study in Japan.

Itsuto Hamano, Shingo Hatakeyama, Hayato Yamamoto, Takeshi Fujita, Reiichi Murakami, Michiko Shimada, Atsushi Imai, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Hisao Saitoh, Tadashi Suzuki, Hirofumi Tomita, Chikara Ohyama

Clinical and experimental nephrology   24 ( 7 )   638 - 645   2020年07月

Outcome of ABO Blood Type-Incompatible Living-Related Donor Kidney Transplantation Under a Contemporary Immunosuppression Strategy in Japan.

Itsuto Hamano, Shingo Hatakeyama, Takeshi Fujita, Reiichi Murakami, Tomoko Hamaya, Kyo Togashi, Yuichiro Suzuki, Hayato Yamamoto, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Shunji Narumi, Hirofumi Tomita, Chikara Ohyama

Transplantation proceedings   52 ( 6 )   1700 - 1704   2020年07月

Living Kidney Transplantation From Marginal Donors Presents Feasible Donor Renal Function Despite Inferior Recipient Renal Function.

Itsuto Hamano, Shingo Hatakeyama, Takeshi Fujita, Reiichi Murakami, Tomoko Hamaya, Kyo Togashi, Yuichiro Suzuki, Hayato Yamamoto, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Shunji Narumi, Hirofumi Tomita, Chikara Ohyama

Transplantation proceedings   52 ( 6 )   1723 - 1728   2020年07月

Outcome of ABO Blood Type-Incompatible Living-Related Donor Kidney Transplantation Under a Contemporary Immunosuppression Strategy in Japan.

Hamano I, Hatakeyama S, Fujita T, Murakami R, Hamaya T, Togashi K, Suzuki Y, Yamamoto H, Yoneyama T, Yoneyama T, Hashimoto Y, Narumi S, Tomita H, Ohyama C

Transplantation proceedings   52 ( 6 )   1700 - 1704   2020年07月

Survey on attitudes toward brain-dead and living donor transplantation in medical students: a cross-sectional study in Japan.

Hamano I, Hatakeyama S, Yamamoto H, Fujita T, Murakami R, Shimada M, Imai A, Yoneyama T, Yoneyama T, Hashimoto Y, Saitoh H, Suzuki T, Tomita H, Ohyama C

Clinical and experimental nephrology   24 ( 7 )   638 - 645   2020年07月

Living Kidney Transplantation From Marginal Donors Presents Feasible Donor Renal Function Despite Inferior Recipient Renal Function.

Hamano I, Hatakeyama S, Fujita T, Murakami R, Hamaya T, Togashi K, Suzuki Y, Yamamoto H, Yoneyama T, Yoneyama T, Hashimoto Y, Narumi S, Tomita H, Ohyama C

Transplantation proceedings   52 ( 6 )   1723 - 1728   2020年07月

Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice.

Yokono Y, Hanada K, Narita M, Tatara Y, Kawamura Y, Miura N, Kitayama K, Nakata M, Nozaka M, Kato T, Kudo N, Tsushima M, Toyama Y, Itoh K, Tomita H

Journal of the American Heart Association   9 ( 12 )   e015616   2020年06月

Predictive ability of creatinine clearance versus estimated glomerular filtration rate for outcomes in patients with non-valvular atrial fibrillation: Subanalysis of the J-RHYTHM Registry.

Eitaro Kodani, Hiroshi Inoue, Hirotsugu Atarashi, Hirofumi Tomita, Ken Okumura, Takeshi Yamashita, Hideki Origasa,

International journal of cardiology. Heart & vasculature   29   100559 - 100559   2020年06月

Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice.

Yoshikazu Yokono, Kenji Hanada, Masato Narita, Yota Tatara, Yousuke Kawamura, Naotake Miura, Kazutaka Kitayama, Masamichi Nakata, Masashi Nozaka, Tomo Kato, Natsumi Kudo, Michiko Tsushima, Yuichi Toyama, Ken Itoh, Hirofumi Tomita

Journal of the American Heart Association   9 ( 12 )   e015616 - e015616   2020年06月

A response to the letter regarding the article, "Isolated prepotential preceding a presumed idiopathic premature ventricular contraction originating from the aortomitral continuity".

Taihei Itoh, Hirofumi Tomita

Journal of cardiovascular electrophysiology   31 ( 5 )   1237 - 1237   2020年05月

A response to the letter regarding the article, "Isolated prepotential preceding a presumed idiopathic premature ventricular contraction originating from the aortomitral continuity".

Itoh T, Tomita H

Journal of cardiovascular electrophysiology   31 ( 5 )   1237   2020年05月

Trends in Prevalence of Non-Valvular Atrial Fibrillation and Anticoagulation Therapy in a Japanese Region　- Analysis Using the National Health Insurance Database.

Narita N, Okumura K, Kinjo T, Mikami J, Tsushima K, Takahashi R, Noro M, Hashimoto A, Sasaki T, Takaki M, Ishidoya E, Narita Y, Imai H, Ono E, Tomita H

Circulation journal : official journal of the Japanese Circulation Society   84 ( 5 )   706 - 713   2020年04月

Risk Factors Associated With Ischemic Stroke in Japanese Patients With Nonvalvular Atrial Fibrillation.

Okumura K, Tomita H, Nakai M, Kodani E, Akao M, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Ogawa H, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Miyata H, Okamura T, Sasahara Y, J-RISK AF Research Group.

JAMA network open   3 ( 4 )   e202881   2020年04月

A novel screening test for inappropriate shocks due to myopotentials from the subcutaneous implantable cardioverter-defibrillator.

Ishida Y, Sasaki S, Toyama Y, Nishizaki K, Shoji Y, Kinjo T, Itoh T, Horiuchi D, Kimura M, Gold MR, Tomita H

Heart rhythm O2   1 ( 1 )   27 - 34   2020年04月

Trends in Prevalence of Non-Valvular Atrial Fibrillation and Anticoagulation Therapy in a Japanese Region　- Analysis Using the National Health Insurance Database.

Noritomo Narita, Ken Okumura, Takahiko Kinjo, Joko Mikami, Katsuko Tsushima, Reiko Takahashi, Makiko Noro, Ayaka Hashimoto, Teiko Sasaki, Misaki Takaki, Emiko Ishidoya, Yurika Narita, Hideno Imai, Emiko Ono, Hirofumi Tomita

Circulation journal : official journal of the Japanese Circulation Society   84 ( 5 )   706 - 713   2020年04月

Risk Factors Associated With Ischemic Stroke in Japanese Patients With Nonvalvular Atrial Fibrillation.

Ken Okumura, Hirofumi Tomita, Michikazu Nakai, Eitaro Kodani, Masaharu Akao, Shinya Suzuki, Kenshi Hayashi, Mitsuaki Sawano, Masahiko Goya, Takeshi Yamashita, Keiichi Fukuda, Hisashi Ogawa, Toyonobu Tsuda, Mitsuaki Isobe, Kazunori Toyoda, Yoshihiro Miyamoto, Hiroaki Miyata, Tomonori Okamura, Yusuke Sasahara,

JAMA network open   3 ( 4 )   e202881 - e202881   2020年04月

Establishment of cardiac action potential recording using a membrane potential indicator in the mouse sinoatrial node

Toyama Yuichi, Yonekura Manabu, Arakawa Yoshiaki, Higuchi Shoki, Tomita Hirofumi, Murakami Agnieszka, Itagaki Shirou, Murakami Manabu

Hirosaki Medical Journal   70 ( 2-4 )   163 - 171   2020年03月

Incidence and clinical impact of thrombus after stent implantation in patients with ST-segment elevation myocardial infarction: an optical coherence tomography study

Kato Tomo, Yokota Takashi, Kitayama Kazutaka, Miura Naotake, Nozaka Masashi, Tsushima Michiko, Kudo Natsumi, Yokono Yoshikazu, Toyama Yuichi, Endo Tomohide, Nishizaki Fumie, Hanada Kenji, Yokoyama Hiroaki, Yamada Masahiro, Tomita Hirofumi

Hirosaki Medical Journal   70 ( 2-4 )   139 - 147   2020年03月

Mutational analysis of β-arrestin in Japanese patients with coronary spastic angina

Kudo Natsumi, Hanada Kenji, Kawamura Yosuke, Nakata Masamichi, Nozaka Masashi, Kitayama Kazutaka, Miura Naotake, Tanaka Makoto, Osanai Tomohiro, Tomita Hirofumi

Hirosaki Medical Journal   70 ( 2-4 )   148 - 155   2020年03月

Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease.

Michiko Tsushima, Jun Liu, Wataru Hirao, Hiromi Yamazaki, Hirofumi Tomita, Ken Itoh

Archives of pharmacal research   43 ( 3 )   286 - 296   2020年03月

Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease.

Tsushima M, Liu J, Hirao W, Yamazaki H, Tomita H, Itoh K

Archives of pharmacal research   43 ( 3 )   286 - 296   2020年03月

Anomalous origin of the coronary artery coursing between the great vessels presenting with a cardiovascular event (J-CONOMALY Registry).

Koichi Nagashima, Takafumi Hiro, Daisuke Fukamachi, Yasuo Okumura, Ichiro Watanabe, Atsushi Hirayama, Masashi Tanaka, Tomofumi Tanaka, Itaru Takamisawa, Isao Taguchi, Akira Sato, Kazutaka Aonuma, Seiji Fukamizu, Akihiro Nakada, Atsuyuki Watanabe, Naofumi Amioka, Yasuyuki Suzuki, Naoya Matsumoto, Junichi Koizumi, Kazuya Kumagai, Masanao Naya, Yoshiharu Higuchi, Yoshiro Naito, Tohru Masuyama, Mitsuharu Kawamura, Ryusuke Tsunoda, Susumu Suzuki, Hideki Ishii, Toyoaki Murohara, Takeshi Shimizu, Yasuchika Takeishi, Kazuki Shiina, Jun Yamashita, Tomohiko Imamura, Naokata Sumitomo, Teruo Noguchi, Toshihide Aso, Kojiro Furukawa, Yasuteru Yamauchi, Kaoru Okishige, Kenji Sakata, Masakazu Yamagishi, Shigeo Shimizu, Masakazu Ohno, Teruyasu Sugano, Koichiro Matsumura, Kensuke Matsumoto, Kazuyuki Ozaki, Shunji Hayashidani, Hiroshi Meno, Atsushi Iwata, Takumi Higuma, Hirofumi Tomita, Hideaki Yoshino, Seiichi Taniai, Koki Shishido, Masato Murakami, Koji Negishi, Masaki Nii, Daisuke Wakatsuki, Hiroshi Suzuki, Yuji Motoike, Yukio Ozaki, Jun Nakazato, Hidemori Hayashi, Satoshi Higuchi, Morio Shoda

European heart journal cardiovascular Imaging   21 ( 2 )   222 - 230   2020年02月

Anomalous origin of the coronary artery coursing between the great vessels presenting with a cardiovascular event (J-CONOMALY Registry).

Nagashima K, Hiro T, Fukamachi D, Okumura Y, Watanabe I, Hirayama A, Tanaka M, Tanaka T, Takamisawa I, Taguchi I, Sato A, Aonuma K, Fukamizu S, Nakada A, Watanabe A, Amioka N, Suzuki Y, Matsumoto N, Koizumi J, Kumagai K, Naya M, Higuchi Y, Naito Y, Masuyama T, Kawamura M, Tsunoda R, Suzuki S, Ishii H, Murohara T, Shimizu T, Takeishi Y, Shiina K, Yamashita J, Imamura T, Sumitomo N, Noguchi T, Aso T, Furukawa K, Yamauchi Y, Okishige K, Sakata K, Yamagishi M, Shimizu S, Ohno M, Sugano T, Matsumura K, Matsumoto K, Ozaki K, Hayashidani S, Meno H, Iwata A, Higuma T, Tomita H, Yoshino H, Taniai S, Shishido K, Murakami M, Negishi K, Nii M, Wakatsuki D, Suzuki H, Motoike Y, Ozaki Y, Nakazato J, Hayashi H, Higuchi S, Shoda M

European heart journal. Cardiovascular Imaging   21 ( 2 )   222 - 230   2020年02月

D-dimer and C-reactive Protein as Potential Biomarkers for Diagnosis of Trousseau's Syndrome in Patients with Cerebral Embolism.

Michiko Tsushima, Norifumi Metoki, Joji Hagii, Shin Saito, Hiroshi Shiroto, Minoru Yasujima, Tomo Kato, Natsumi Kudo, Yuichi Toyama, Yoshikazu Yokono, Masashi Nozaka, Yosuke Kawamura, Masamichi Nakata, Hirofumi Tomita

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   29 ( 2 )   104534 - 104534   2020年02月

Leptin/adiponectin ratio correlates with hepatic steatosis but not arterial stiffness in nonalcoholic fatty liver disease in Japanese population.

Kenichiro Mikami, Tetsu Endo, Naoya Sawada, Go Igarashi, Masayo Kimura, Takuma Hasegawa, Chikara Iino, Hirofumi Tomita, Kaori Sawada, Shigeyuki Nakaji, Masashi Matsuzaka, Natalie J Torok, Shinsaku Fukuda

Cytokine   126   154927 - 154927   2020年02月

D-dimer and C-reactive Protein as Potential Biomarkers for Diagnosis of Trousseau's Syndrome in Patients with Cerebral Embolism.

Tsushima M, Metoki N, Hagii J, Saito S, Shiroto H, Yasujima M, Kato T, Kudo N, Toyama Y, Yokono Y, Nozaka M, Kawamura Y, Nakata M, Tomita H

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   29 ( 2 )   104534   2020年02月

Leptin/adiponectin ratio correlates with hepatic steatosis but not arterial stiffness in nonalcoholic fatty liver disease in Japanese population.

Mikami K, Endo T, Sawada N, Igarashi G, Kimura M, Hasegawa T, Iino C, Tomita H, Sawada K, Nakaji S, Matsuzaka M, Torok NJ, Fukuda S

Cytokine   126   154927   2020年02月

前立腺癌で加療中にたこつぼ型心筋症を発症し、後にステロイド自己中断による副腎不全が判明した1例

酒井　峻太郎、西崎　史恵、富田　泰史　他

心臓   52 ( 1 )   70 - 74   2020年01月

Breakout site shift to the right bundle branch during an idiopathic premature ventricular contraction originating from the left bundle branch.

Taihei Itoh, Masaomi Kimura, Yuichi Toyama, Kimitaka Nishizaki, Hirofumi Tomita

Journal of cardiovascular electrophysiology   31 ( 1 )   229 - 230   2020年01月

Breakout site shift to the right bundle branch during an idiopathic premature ventricular contraction originating from the left bundle branch.

Itoh T, Kimura M, Toyama Y, Nishizaki K, Tomita H

Journal of cardiovascular electrophysiology   31 ( 1 )   229 - 230   2020年01月

Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging.

Shimizu S, Mimura J, Hasegawa T, Shimizu E, Imoto S, Tsushima M, Kasai S, Yamazaki H, Ushida Y, Suganuma H, Tomita H, Yamamoto M, Nakaji S, Itoh K

PloS one   15 ( 8 )   e0236834   2020年

Decreased cardiac pacemaking and attenuated β-adrenergic response in TRIC-A knockout mice.

Murakami M, Toyama Y, Yonekura M, Ohba T, Matsuzaki Y, Sawamura D, Murakami AM, Nishi M, Itagaki S, Tomita H, Takeshima H

PloS one   15 ( 12 )   e0244254   2020年

Isolated prepotential preceding a presumed idiopathic premature ventricular contraction originating from the aortomitral continuity.

Taihei Itoh, Masaomi Kimura, Hirofumi Tomita

Journal of cardiovascular electrophysiology   30 ( 12 )   2988 - 2989   2019年12月

Multiple simultaneous mid-diastolic potentials recorded on a grid mapping catheter during a scar-related reentrant ventricular tachycardia: Are all potentials within a critical isthmus?

Taihei Itoh, Masaomi Kimura, Kimitaka Nishizaki, Hirofumi Tomita

Journal of cardiovascular electrophysiology   30 ( 12 )   2984 - 2985   2019年12月

Prognostic impact of body mass index and culprit lesion calcification in patients with acute myocardial infarction.

Hiroaki Yokoyama, Takumi Higuma, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Takashi Yokota, Masahiro Yamada, Ken Okumura, Hirofumi Tomita

Heart and vessels   34 ( 12 )   1909 - 1916   2019年12月

Prognostic impact of body mass index and culprit lesion calcification in patients with acute myocardial infarction.

Yokoyama H, Higuma T, Endo T, Nishizaki F, Hanada K, Yokota T, Yamada M, Okumura K, Tomita H

Heart and vessels   34 ( 12 )   1909 - 1916   2019年12月

Multiple simultaneous mid-diastolic potentials recorded on a grid mapping catheter during a scar-related reentrant ventricular tachycardia: Are all potentials within a critical isthmus?

Itoh T, Kimura M, Nishizaki K, Tomita H

Journal of cardiovascular electrophysiology   30 ( 12 )   2984 - 2985   2019年12月

Isolated prepotential preceding a presumed idiopathic premature ventricular contraction originating from the aortomitral continuity.

Itoh T, Kimura M, Tomita H

Journal of cardiovascular electrophysiology   30 ( 12 )   2988 - 2989   2019年12月

Modified hockey stick maneuver utilizing a steerable cryoballoon catheter for left inferior pulmonary vein isolation.

Taihei Itoh, Masaomi Kimura, Hirofumi Tomita

Journal of arrhythmia   35 ( 5 )   739 - 741   2019年10月

Modified hockey stick maneuver utilizing a steerable cryoballoon catheter for left inferior pulmonary vein isolation.

Itoh T, Kimura M, Tomita H

Journal of arrhythmia   35 ( 5 )   739 - 741   2019年10月

Demonstration of an adjacent conduction gaps-derived left atrial and pulmonary vein flutter by high-density mapping.

Taihei Itoh, Masaomi Kimura, Hirofumi Tomita

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   55 ( 3 )   361 - 361   2019年09月

Demonstration of an adjacent conduction gaps-derived left atrial and pulmonary vein flutter by high-density mapping.

Itoh T, Kimura M, Tomita H

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   55 ( 3 )   361   2019年09月

IQGAP1 activates PLC-δ1 by direct binding and moving along microtubule with DLC-1 to cell surface.

Makoto Tanaka, Tomohiro Osanai, Yoshimi Homma, Kenji Hanada, Ken Okumura, Hirofumi Tomita

FASEB bioAdvances   1 ( 8 )   465 - 480   2019年08月

IQGAP1 activates PLC-δ1 by direct binding and moving along microtubule with DLC-1 to cell surface.

Tanaka M, Osanai T, Homma Y, Hanada K, Okumura K, Tomita H

FASEB bioAdvances   1 ( 8 )   465 - 480   2019年08月

Secondary haemophagocytic lymphohistiocytosis associated with metronidazole.

Iio K, Ariyama Y, Tomita H, Sakakibara H, Hataya H

Postgraduate medical journal   95 ( 1125 )   390   2019年07月

In situ needle deflection technique using a steerable introducer for site-selective radiofrequency transseptal puncture.

Taihei Itoh, Masaomi Kimura, Yuji Ishida, Hirofumi Tomita

Journal of arrhythmia   35 ( 3 )   565 - 567   2019年06月

Impact of distance between donor and recipient hospitals on cadaveric kidney transplantation outcomes.

Itsuto Hamano, Shingo Hatakeyama, Hayato Yamamoto, Takeshi Fujita, Reiichi Murakami, Michiko Shimada, Atsushi Imai, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Shunji Narumi, Hisao Saitoh, Tadashi Suzuki, Hirofumi Tomita, Chikara Ohyama

Clinical and experimental nephrology   23 ( 6 )   807 - 813   2019年06月

Long-term outcomes in Japanese nonagenarians undergoing transcatheter aortic valve implantation: A multi-center analysis.

Hiroaki Yokoyama, Tetsuya Tobaru, Yuki Muto, Kenichi Hagiya, Ryosuke Higuchi, Mike Saji, Itaru Takamisawa, Jun Shimizu, Shuichiro Takanashi, Morimasa Takayama, Hirofumi Tomita, Harutoshi Tamura, Shinichiro Doi, Shinya Okazaki, Mitsuaki Isobe

Clinical cardiology   42 ( 6 )   605 - 611   2019年06月

Impact of distance between donor and recipient hospitals on cadaveric kidney transplantation outcomes.

Hamano I, Hatakeyama S, Yamamoto H, Fujita T, Murakami R, Shimada M, Imai A, Yoneyama T, Yoneyama T, Hashimoto Y, Koie T, Narumi S, Saitoh H, Suzuki T, Tomita H, Ohyama C

Clinical and experimental nephrology   23 ( 6 )   807 - 813   2019年06月

In situ needle deflection technique using a steerable introducer for site-selective radiofrequency transseptal puncture.

Itoh T, Kimura M, Ishida Y, Tomita H

Journal of arrhythmia   35 ( 3 )   565 - 567   2019年06月

Long-term outcomes in Japanese nonagenarians undergoing transcatheter aortic valve implantation: A multi-center analysis.

Yokoyama H, Tobaru T, Muto Y, Hagiya K, Higuchi R, Saji M, Takamisawa I, Shimizu J, Takanashi S, Takayama M, Tomita H, Tamura H, Doi S, Okazaki S, Isobe M

Clinical cardiology   42 ( 6 )   605 - 611   2019年06月

Novel Electrocardiographic Criteria for the Diagnosis of Left Ventricular Hypertrophy in the Japanese General Population.

Masato Narita, Masahiro Yamada, Michiko Tsushima, Natsumi Kudo, Tomo Kato, Yoshikazu Yokono, Yuichi Toyama, Maiko Senoo, Manabu Yonekura, Noritomo Narita, Yoshihiro Kimura, Kaori Sawada, Itoyo Tokuda, Hirofumi Tomita

International heart journal   60 ( 3 )   679 - 687   2019年05月

Novel Electrocardiographic Criteria for the Diagnosis of Left Ventricular Hypertrophy in the Japanese General Population.

Narita M, Yamada M, Tsushima M, Kudo N, Kato T, Yokono Y, Toyama Y, Senoo M, Yonekura M, Narita N, Kimura Y, Sawada K, Tokuda I, Tomita H

International heart journal   60 ( 3 )   679 - 687   2019年05月

Interpolated Purkinje potentials recorded at a successful ablation site of a fascicular premature ventricular contraction during sinus rhythm.

Taihei Itoh, Masaomi Kimura, Yuji Ishida, Hirofumi Tomita

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology   21 ( 5 )   715 - 715   2019年05月

Interpolated Purkinje potentials recorded at a successful ablation site of a fascicular premature ventricular contraction during sinus rhythm.

Itoh T, Kimura M, Ishida Y, Tomita H

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology   21 ( 5 )   715   2019年05月

Nonendocardial Isthmus Involving a Protected Part Within the Endocardial Scar in an Ischemic Ventricular Tachycardia.

Taihei Itoh, Masaomi Kimura, Yuji Ishida, Hirofumi Tomita

JACC. Clinical electrophysiology   5 ( 5 )   637 - 638   2019年05月

Nonendocardial Isthmus Involving a Protected Part Within the Endocardial Scar in an Ischemic Ventricular Tachycardia.

Itoh T, Kimura M, Ishida Y, Tomita H

JACC. Clinical electrophysiology   5 ( 5 )   637 - 638   2019年05月

Rivaroxaban, a Direct Factor Xa Inhibitor, Ameliorates Hypertensive Renal Damage Through Inhibition of the Inflammatory Response Mediated by Protease-Activated Receptor Pathway.

Hiroaki Ichikawa, Michiko Shimada, Masato Narita, Ikuyo Narita, Yoshihiro Kimura, Makoto Tanaka, Tomohiro Osanai, Ken Okumura, Hirofumi Tomita

Journal of the American Heart Association   8 ( 8 )   e012195 - e012195   2019年04月

Rivaroxaban, a Direct Factor Xa Inhibitor, Ameliorates Hypertensive Renal Damage Through Inhibition of the Inflammatory Response Mediated by Protease-Activated Receptor Pathway.

Ichikawa H, Shimada M, Narita M, Narita I, Kimura Y, Tanaka M, Osanai T, Okumura K, Tomita H

Journal of the American Heart Association   8 ( 8 )   e012195   2019年04月

Prognostic impact of snow shoveling for patients with acute myocardial infarction

Maiko Senoo, Hiroaki Yokoyama, Tomo Kato, Natsumi Kudo, Yoshikazu Yokono, Michiko Tsushima, Yuichi Toyama, Noritomo Narita, Masato Narita, Hirofumi Tomita

Hirosaki Medical Journal   69   136 - 145   2019年03月

Involvement of beta-arrestin in endothelin receptor signaling: A possible role in the pathogenesis of pulmonary arterial hypertension

Noritomo Narita, Kenji Hanada, Maiko Senoo, Tomo Kato, Natsumi Kudo, Yoshikazu Yokono, Michiko Tsushima, Yuichi Toyama, Masato Narita, Hirofumi Tomita

Hirosaki Medical Journal   69   146 - 154   2019年03月

Sufficient and Persistent Blood Pressure Reduction in the Final Long-Term Results From SYMPLICITY HTN-Japan　- Safety and Efficacy of Renal Denervation at 3 Years.

Kazuomi Kario, Eiichiro Yamamoto, Hirofumi Tomita, Takafumi Okura, Shigeru Saito, Takafumi Ueno, Daiki Yasuhara, Kazuyuki Shimada,

Circulation journal : official journal of the Japanese Circulation Society   83 ( 3 )   622 - 629   2019年02月

Sufficient and Persistent Blood Pressure Reduction in the Final Long-Term Results From SYMPLICITY HTN-Japan　- Safety and Efficacy of Renal Denervation at 3 Years.

Kario K, Yamamoto E, Tomita H, Okura T, Saito S, Ueno T, Yasuhara D, Shimada K, SYMPLICITY HTN-Japan Investigators.

Circulation journal : official journal of the Japanese Circulation Society   83 ( 3 )   622 - 629   2019年02月

Open-Label Randomized Trial Comparing Oral Anticoagulation With and Without Single Antiplatelet Therapy in Patients With Atrial Fibrillation and Stable Coronary Artery Disease Beyond 1 Year After Coronary Stent Implantation.

Yukiko Matsumura-Nakano, Satoshi Shizuta, Akihiro Komasa, Takeshi Morimoto, Hisaki Masuda, Hiroki Shiomi, Koji Goto, Kentaro Nakai, Hisashi Ogawa, Atsushi Kobori, Yutaka Kono, Kazuaki Kaitani, Satoru Suwa, Takeshi Aoyama, Mamoru Takahashi, Yasuhiro Sasaki, Yuko Onishi, Toshiaki Mano, Mitsuo Matsuda, Makoto Motooka, Hirofumi Tomita, Moriaki Inoko, Takatoshi Wakeyama, Nobuhisa Hagiwara, Kengo Tanabe, Masaharu Akao, Katsumi Miyauchi, Junji Yajima, Keiichi Hanaoka, Yoshihiro Morino, Kenji Ando, Yutaka Furukawa, Yoshihisa Nakagawa, Koichi Nakao, Ken Kozuma, Kazushige Kadota, Kazuo Kimura, Kazuya Kawai, Takafumi Ueno, Ken Okumura, Takeshi Kimura,

Circulation   139 ( 5 )   604 - 616   2019年01月

Open-Label Randomized Trial Comparing Oral Anticoagulation With and Without Single Antiplatelet Therapy in Patients With Atrial Fibrillation and Stable Coronary Artery Disease Beyond 1 Year After Coronary Stent Implantation.

Matsumura-Nakano Y, Shizuta S, Komasa A, Morimoto T, Masuda H, Shiomi H, Goto K, Nakai K, Ogawa H, Kobori A, Kono Y, Kaitani K, Suwa S, Aoyama T, Takahashi M, Sasaki Y, Onishi Y, Mano T, Matsuda M, Motooka M, Tomita H, Inoko M, Wakeyama T, Hagiwara N, Tanabe K, Akao M, Miyauchi K, Yajima J, Hanaoka K, Morino Y, Ando K, Furukawa Y, Nakagawa Y, Nakao K, Kozuma K, Kadota K, Kimura K, Kawai K, Ueno T, Okumura K, Kimura T, OAC-ALONE Study Investigators.

Circulation   139 ( 5 )   604 - 616   2019年01月

Intracellular protons accelerate aging and switch on aging hallmarks in mice.

Tomohiro Osanai, Makoto Tanaka, Kei Izumiyama, Kasumi Mikami, Maiko Kitajima, Toshiko Tomisawa, Koji Magota, Hirofumi Tomita, Ken Okumura

Journal of cellular biochemistry   119 ( 12 )   9825 - 9837   2018年12月

Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway.

Tomohiro Osanai, Makoto Tanaka, Kasumi Mikami, Maiko Kitajima, Toshiko Tomisawa, Koji Magota, Hirofumi Tomita, Ken Okumura

Journal of molecular and cellular cardiology   125   174 - 184   2018年12月

Prasugrel versus clopidogrel for residual thrombus burden in patients with ST-segment elevation myocardial infarction: an optical coherence tomography study.

Takashi Yokota, Takumi Higuma, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Hiroaki Yokoyama, Masahiro Yamada, Ken Okumura, Hirofumi Tomita

Coronary artery disease   29 ( 8 )   663 - 669   2018年12月

Reply to the Letter to the Editor "'30-minute-delta' and biological variation of high-sensitivity cardiac troponin I".

Yokoyama H, Tomita H

Journal of cardiology   72 ( 6 )   506 - 507   2018年12月

Prasugrel versus clopidogrel for residual thrombus burden in patients with ST-segment elevation myocardial infarction: an optical coherence tomography study.

Yokota T, Higuma T, Endo T, Nishizaki F, Hanada K, Yokoyama H, Yamada M, Okumura K, Tomita H

Coronary artery disease   29 ( 8 )   663 - 669   2018年12月

Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway.

Osanai T, Tanaka M, Mikami K, Kitajima M, Tomisawa T, Magota K, Tomita H, Okumura K

Journal of molecular and cellular cardiology   125   174 - 184   2018年12月

Intracellular protons accelerate aging and switch on aging hallmarks in mice.

Osanai T, Tanaka M, Izumiyama K, Mikami K, Kitajima M, Tomisawa T, Magota K, Tomita H, Okumura K

Journal of cellular biochemistry   119 ( 12 )   9825 - 9837   2018年12月

Blood Pressure-Independent Effect of Olmesartan on Albuminuria in Mice Overexpressing Renin.

Hiroaki Ichikawa, Ikuyo Narita, Masato Narita, Tomohiro Tanno, Yoshikazu Yokono, Yoshihiro Kimura, Makoto Tanaka, Tomohiro Osanai, Ken Okumura, Hirofumi Tomita

International heart journal   59 ( 6 )   1445 - 1453   2018年11月

Blood Pressure-Independent Effect of Olmesartan on Albuminuria in Mice Overexpressing Renin.

Ichikawa H, Narita I, Narita M, Tanno T, Yokono Y, Kimura Y, Tanaka M, Osanai T, Okumura K, Tomita H

International heart journal   59 ( 6 )   1445 - 1453   2018年11月

Low Body Mass Index is a Poor Prognosis Factor in Cardioembolic Stroke Patients with NonValvular Atrial Fibrillation.

Joji Hagii, Norifumi Metoki, Shin Saito, Ayaka Fujita, Hiroshi Shiroto, Satoko Sasaki, Koki Takahashi, Hiroyasu Hitomi, Yoshiko Baba, Satoshi Seino, Takaatu Kamada, Takamitsu Uchizawa, Manabu Iwata, Shigeo Matsumoto, Minoru Yasujima, Hirofumi Tomita

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   27 ( 11 )   3155 - 3162   2018年11月

Neuroimaging and clinical outcomes of oral anticoagulant-associated intracerebral hemorrhage.

Georgios Tsivgoulis, Duncan Wilson, Aristeidis H Katsanos, João Sargento-Freitas, Cláudia Marques-Matos, Elsa Azevedo, Tomohide Adachi, Christian von der Brelie, Yoshifusa Aizawa, Hiroshi Abe, Hirofumi Tomita, Ken Okumura, Joji Hagii, David J Seiffge, Vasileios-Arsenios Lioutas, Christopher Traenka, Panayiotis Varelas, Ghazala Basir, Christos Krogias, Jan C Purrucker, Vijay K Sharma, Timolaos Rizos, Robert Mikulik, Oluwaseun A Sobowale, Kristian Barlinn, Hanne Sallinen, Nitin Goyal, Shin-Joe Yeh, Theodore Karapanayiotides, Teddy Y Wu, Konstantinos Vadikolias, Marc Ferrigno, Georgios Hadjigeorgiou, Rik Houben, Sotirios Giannopoulos, Floris H B M Schreuder, Jason J Chang, Luke A Perry, Maximilian Mehdorn, João-Pedro Marto, João Pinho, Jun Tanaka, Marion Boulanger, Rustam Al-Shahi Salman, Hans R Jäger, Clare Shakeshaft, Yusuke Yakushiji, Philip M C Choi, Julie Staals, Charlotte Cordonnier, Jiann-Shing Jeng, Roland Veltkamp, Dar Dowlatshahi, Stefan T Engelter, Adrian R Parry-Jones, Atte Meretoja, Panayiotis D Mitsias, Andrei V Alexandrov, Gareth Ambler, David J Werring

Annals of neurology   84 ( 5 )   694 - 704   2018年11月

Low Body Mass Index is a Poor Prognosis Factor in Cardioembolic Stroke Patients with NonValvular Atrial Fibrillation.

Hagii J, Metoki N, Saito S, Fujita A, Shiroto H, Sasaki S, Takahashi K, Hitomi H, Baba Y, Seino S, Kamada T, Uchizawa T, Iwata M, Matsumoto S, Yasujima M, Tomita H

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   27 ( 11 )   3155 - 3162   2018年11月

Neuroimaging and clinical outcomes of oral anticoagulant-associated intracerebral hemorrhage.

Tsivgoulis G, Wilson D, Katsanos AH, Sargento-Freitas J, Marques-Matos C, Azevedo E, Adachi T, von der Brelie C, Aizawa Y, Abe H, Tomita H, Okumura K, Hagii J, Seiffge DJ, Lioutas VA, Traenka C, Varelas P, Basir G, Krogias C, Purrucker JC, Sharma VK, Rizos T, Mikulik R, Sobowale OA, Barlinn K, Sallinen H, Goyal N, Yeh SJ, Karapanayiotides T, Wu TY, Vadikolias K, Ferrigno M, Hadjigeorgiou G, Houben R, Giannopoulos S, Schreuder FHBM, Chang JJ, Perry LA, Mehdorn M, Marto JP, Pinho J, Tanaka J, Boulanger M, Al-Shahi Salman R, Jäger HR, Shakeshaft C, Yakushiji Y, Choi PMC, Staals J, Cordonnier C, Jeng JS, Veltkamp R, Dowlatshahi D, Engelter ST, Parry-Jones AR, Meretoja A, Mitsias PD, Alexandrov AV, Ambler G, Werring DJ

Annals of neurology   84 ( 5 )   694 - 704   2018年11月

Intramural right ventricular inflow tract ventricular tachycardia successfully ablated from the anteroseptal tricuspid annulus and the right coronary cusp.

Taihei Itoh, Masaomi Kimura, Hirofumi Tomita

Journal of cardiovascular electrophysiology   29 ( 10 )   1446 - 1447   2018年10月

Single atrial premature depolarizations for differential diagnosis of a long RP tachycardia: What is the diagnosis?

Taihei Itoh, Masaomi Kimura, Yuji Ishida, Hirofumi Tomita

Journal of cardiovascular electrophysiology   29 ( 10 )   1457 - 1459   2018年10月

Intramural right ventricular inflow tract ventricular tachycardia successfully ablated from the anteroseptal tricuspid annulus and the right coronary cusp.

Itoh T, Kimura M, Tomita H

Journal of cardiovascular electrophysiology   29 ( 10 )   1446 - 1447   2018年10月

Single atrial premature depolarizations for differential diagnosis of a long RP tachycardia: What is the diagnosis?

Itoh T, Kimura M, Ishida Y, Tomita H

Journal of cardiovascular electrophysiology   29 ( 10 )   1457 - 1459   2018年10月

Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan.

Yoshihiro Kimura, Masahiro Yamada, Kenji Hanada, Tomohide Endo, Noritomo Narita, Masato Narita, Maiko Senoo, Manabu Yonekura, Hiroaki Ichikawa, Shizuka Kurauchi, Shigeyuki Nakaji, Ken Okumura, Hirofumi Tomita

International heart journal   59 ( 4 )   736 - 740   2018年07月

Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan.

Kimura Y, Yamada M, Hanada K, Endo T, Narita N, Narita M, Senoo M, Yonekura M, Ichikawa H, Kurauchi S, Nakaji S, Okumura K, Tomita H

International heart journal   59 ( 4 )   736 - 740   2018年07月

Cycle length alternans during an atypical atrioventricular nodal re-entrant tachycardia utilizing a superior slow pathway.

Taihei Itoh, Masaomi Kimura, Yuji Ishida, Hirofumi Tomita

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology   20 ( 7 )   1114 - 1114   2018年07月

Cycle length alternans during an atypical atrioventricular nodal re-entrant tachycardia utilizing a superior slow pathway.

Itoh T, Kimura M, Ishida Y, Tomita H

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology   20 ( 7 )   1114   2018年07月

Mitochondrial inhibitory factor protein 1 attenuates coupling factor 6-induced aging signal.

Tomohiro Osanai, Makoto Tanaka, Kasumi Mikami, Maiko Kitajima, Koji Magota, Hirofumi Tomita, Ken Okumura

Journal of cellular biochemistry   119 ( 7 )   6194 - 6203   2018年07月

Covert atrial fibrillation and atrial high-rate episodes as a potential cause of embolic strokes of undetermined source: Their detection and possible management strategy.

Hirofumi Tomita, Shingo Sasaki, Joji Hagii, Norifumi Metoki

Journal of cardiology   72 ( 1 )   1 - 9   2018年07月

Covert atrial fibrillation and atrial high-rate episodes as a potential cause of embolic strokes of undetermined source: Their detection and possible management strategy.

Tomita H, Sasaki S, Hagii J, Metoki N

Journal of cardiology   72 ( 1 )   1 - 9   2018年07月

Mitochondrial inhibitory factor protein 1 attenuates coupling factor 6-induced aging signal.

Osanai T, Tanaka M, Mikami K, Kitajima M, Magota K, Tomita H, Okumura K

Journal of cellular biochemistry   119 ( 7 )   6194 - 6203   2018年07月

Safety and Efficacy of Subcutaneous Cardioverter Defibrillator in Patients at High Risk of Sudden Cardiac Death　- Primary Japanese Experience.

Shingo Sasaki, Hirofumi Tomita, Takuo Tsurugi, Yuji Ishida, Yoshihiro Shoji, Kimitaka Nishizaki, Takahiko Kinjo, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Kenichi Sasaki, Daisuke Horiuchi, Masaomi Kimura, Takumi Higuma, Hideharu Okamatsu, Yasuaki Tanaka, Junjiroh Koyama, Ken Okumura

Circulation journal : official journal of the Japanese Circulation Society   82 ( 6 )   1546 - 1551   2018年05月

Safety and Efficacy of Subcutaneous Cardioverter Defibrillator in Patients at High Risk of Sudden Cardiac Death　- Primary Japanese Experience.

Sasaki S, Tomita H, Tsurugi T, Ishida Y, Shoji Y, Nishizaki K, Kinjo T, Endo T, Nishizaki F, Hanada K, Sasaki K, Horiuchi D, Kimura M, Higuma T, Okamatsu H, Tanaka Y, Koyama J, Okumura K

Circulation journal : official journal of the Japanese Circulation Society   82 ( 6 )   1546 - 1551   2018年05月

Medaka as a model for ECG analysis and the effect of verapamil.

Manabu Yonekura, Nami Kondoh, Chong Han, Yuichi Toyama, Takayoshi Ohba, Kyoichi Ono, Shirou Itagaki, Hirofumi Tomita, Manabu Murakami

Journal of pharmacological sciences   137 ( 1 )   55 - 60   2018年05月

Medaka as a model for ECG analysis and the effect of verapamil.

Yonekura M, Kondoh N, Han C, Toyama Y, Ohba T, Ono K, Itagaki S, Tomita H, Murakami M

Journal of pharmacological sciences   137 ( 1 )   55 - 60   2018年05月

Partial Cystectomy of Paraganglioma of the Urinary Bladder Before Living Kidney Transplantation: Case Report.

K Kido, S Hatakeyama, I Hamano, H Yamamoto, A Imai, T Yoneyama, Y Hashimoto, T Koie, T Fujita, R Murakami, H Tomita, T Suzuki, S Narumi, C Ohyama

Transplantation proceedings   50 ( 3 )   898 - 901   2018年04月

Use of wearable cardioverter defibrillator shortens the ICU stay and enables safe management in a general ward

Yoshihiro Shoji, Shingo Sasaki, Yuichi Toyama, Kimitaka Nishizaki, Takahiko Kinjo, Yuji Ishida, Tomohide Endo, Fumie Nishizaki, Taihei Itoh, Takashi Yokota, Hiroaki Yokoyama, Masahiro Yamada, Daisuke Horiuchi, Masaomi Kimura, Takumi Higuma, Ken Okumura, Hirofumi Tomita

Hirosaki Medical Journal   68   135 - 141   2018年03月

"30-minute-delta" of high-sensitivity troponin I improves diagnostic performance in acute myocardial infarction.

Hiroaki Yokoyama, Takumi Higuma, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Takashi Yokota, Masahiro Yamada, Ken Okumura, Hirofumi Tomita

Journal of cardiology   71 ( 2 )   144 - 148   2018年02月

"30-minute-delta" of high-sensitivity troponin I improves diagnostic performance in acute myocardial infarction.

Yokoyama H, Higuma T, Endo T, Nishizaki F, Hanada K, Yokota T, Yamada M, Okumura K, Tomita H

Journal of cardiology   71 ( 2 )   144 - 148   2018年02月

Corrigendum for "Impact of Atrial Natriuretic Peptide Value for Predicting Paroxysmal Atrial Fibrillation in Ischemic Stroke Patients" [J Stroke Cerebrovasc Dis. 2017;26:772-778].

Shiroto H, Tomita H, Hagii J, Metoki N, Fujita A, Kamada T, Takahashi K, Saito S, Sasaki S, Hitomi H, Seino S, Baba Y, Uchizawa T, Iwata M, Matsumoto S, Yasujima M, Okumura K

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   27 ( 1 )   276   2018年01月

influx in the cells with phospholipase C-δ1 overexpression: its possible role in coronary artery spasm.

Kazuo Murakami, Tomohiro Osanai, Makoto Tanaka, Kimitaka Nishizaki, Takahiko Kinjo, Tomohiro Tanno, Yuji Ishida, Akiko Suzuki, Tomohide Endo, Hirofumi Tomita, Ken Okumura

Fundamental & clinical pharmacology   31 ( 4 )   383 - 391   2017年08月

Enhanced transient receptor potential channel-mediated Ca²⁺ influx in the cells with phospholipase C-δ1 overexpression: its possible role in coronary artery spasm.

Murakami K, Osanai T, Tanaka M, Nishizaki K, Kinjo T, Tanno T, Ishida Y, Suzuki A, Endo T, Tomita H, Okumura K

Fundamental & clinical pharmacology   31 ( 4 )   383 - 391   2017年08月

Safety and efficacy of contemporary catheter ablation for atrial fibrillation patients with a history of cardioembolic stroke in the era of direct oral anticoagulants.

Kimitaka Nishizaki, Taihei Itoh, Masaomi Kimura, Yuichi Tsushima, Yoshihiro Shoji, Takahiko Kinjo, Yuji Ishida, Kenichi Sasaki, Daisuke Horiuchi, Shingo Sasaki, Hirofumi Tomita, Ken Okumura

Journal of cardiology   70 ( 1 )   86 - 91   2017年07月

Safety and efficacy of contemporary catheter ablation for atrial fibrillation patients with a history of cardioembolic stroke in the era of direct oral anticoagulants.

Nishizaki K, Itoh T, Kimura M, Tsushima Y, Shoji Y, Kinjo T, Ishida Y, Sasaki K, Horiuchi D, Sasaki S, Tomita H, Okumura K

Journal of cardiology   70 ( 1 )   86 - 91   2017年07月

Nutritional regulation of coupling factor 6, a novel vasoactive and proatherogenic peptide.

Tomohiro Osanai, Kasumi Mikami, Maiko Kitajima, Mayumi Urushizaka, Kumiko Kawasaki, Toshiko Tomisawa, Chieko Itaki, Yuka Noto, Koji Magota, Hirofumi Tomita

Nutrition (Burbank, Los Angeles County, Calif.)   37   74 - 78   2017年05月

Nutritional regulation of coupling factor 6, a novel vasoactive and proatherogenic peptide.

Osanai T, Mikami K, Kitajima M, Urushizaka M, Kawasaki K, Tomisawa T, Itaki C, Noto Y, Magota K, Tomita H

Nutrition (Burbank, Los Angeles County, Calif.)   37   74 - 78   2017年05月

Impact of Atrial Natriuretic Peptide Value for Predicting Paroxysmal Atrial Fibrillation in Ischemic Stroke Patients.

Hiroshi Shiroto, Hirofumi Tomita, Joji Hagii, Norifumi Metoki, Ayaka Fujita, Takaatsu Kamada, Koki Takahashi, Shin Saito, Satoko Sasaki, Hiroyasu Hitomi, Satoshi Seino, Yoshiko Baba, Takamitsu Uchizawa, Manabu Iwata, Shigeo Matsumoto, Minoru Yasujima, Ken Okumura

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   26 ( 4 )   772 - 778   2017年04月

Impact of Atrial Natriuretic Peptide Value for Predicting Paroxysmal Atrial Fibrillation in Ischemic Stroke Patients.

Shiroto H, Tomita H, Hagii J, Metoki N, Fujita A, Kamada T, Takahashi K, Saito S, Sasaki S, Hitomi H, Seino S, Baba Y, Uchizawa T, Iwata M, Matsumoto S, Yasujima M, Okumura K

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   26 ( 4 )   772 - 778   2017年04月

Daclatasvir/asunaprevir based direct-acting antiviral therapy ameliorate hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis: a case report.

Michiko Shimada, Norio Nakamura, Tetsu Endo, Hideaki Yamabe, Masayuki Nakamura, Reiichi Murakami, Ikuyo Narita, Hirofumi Tomita

BMC nephrology   18 ( 1 )   109 - 109   2017年03月

Daclatasvir/asunaprevir based direct-acting antiviral therapy ameliorate hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis: a case report.

Shimada M, Nakamura N, Endo T, Yamabe H, Nakamura M, Murakami R, Narita I, Tomita H

BMC nephrology   18 ( 1 )   109   2017年03月

Potential roles of the wearable cardioverter-defibrillator in acute phase care of patients at high risk of sudden cardiac death: A single-center Japanese experience.

Shingo Sasaki, Yoshihiro Shoji, Yuji Ishida, Takahiko Kinjo, Yuichi Tsushima, Maiko Seno, Fumie Nishizaki, Taihei Itoh, Kei Izumiyama, Takashi Yokota, Hiroaki Yokoyama, Masahiro Yamada, Daisuke Horiuchi, Masaomi Kimura, Takumi Higuma, Hirofumi Tomita, Ken Okumura

Journal of Cardiology   69 ( 1 )   359 - 363   2017年01月

Potential roles of the wearable cardioverter-defibrillator in acute phase care of patients at high risk of sudden cardiac death: A single-center Japanese experience.

Sasaki S, Shoji Y, Ishida Y, Kinjo T, Tsushima Y, Seno M, Nishizaki F, Itoh T, Izumiyama K, Yokota T, Yokoyama H, Yamada M, Horiuchi D, Kimura M, Higuma T, Tomita H, Okumura K

Journal of cardiology   69 ( 1 )   359 - 363   2017年01月

Successful Resuscitation of a Patient with Life-Threatening Metabolic Acidosis by Hemodialysis: A Case of Ethylene Glycol Intoxication.

Ikuyo Narita, Michiko Shimada, Norio Nakamura, Reiichi Murakami, Takeshi Fujita, Wakako Fukuda, Hirofumi Tomita

Case reports in nephrology   2017   9529028 - 9529028   2017年

Successful Resuscitation of a Patient with Life-Threatening Metabolic Acidosis by Hemodialysis: A Case of Ethylene Glycol Intoxication.

Narita I, Shimada M, Nakamura N, Murakami R, Fujita T, Fukuda W, Tomita H

Case reports in nephrology   2017   9529028   2017年

Effect of rivaroxaban on prothrombin fragment 1+2 compared with warfarin in patients with acute cardioembolic stroke: Insight from its serial measurement.

Joji Hagii, Hirofumi Tomita, Norifumi Metoki, Yoshiko Tamai, Shin Saito, Hiroshi Shiroto, Hiroyasu Hitomi, Takaatsu Kamada, Satoshi Seino, Koki Takahashi, Satoko Sasaki, Minoru Yasujima, Ken Okumura

Thrombosis research   148   9 - 14   2016年12月

Effect of rivaroxaban on prothrombin fragment 1+2 compared with warfarin in patients with acute cardioembolic stroke: Insight from its serial measurement.

Hagii J, Tomita H, Metoki N, Tamai Y, Saito S, Shiroto H, Hitomi H, Kamada T, Seino S, Takahashi K, Sasaki S, Yasujima M, Okumura K

Thrombosis research   148   9 - 14   2016年12月

Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase.

Albert S Chang, Ruriko Grant, Hirofumi Tomita, Hyung-Suk Kim, Oliver Smithies, Masao Kakoki

Proceedings of the National Academy of Sciences of the United States of America   113 ( 44 )   12538 - 12543   2016年11月

Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase.

Chang AS, Grant R, Tomita H, Kim HS, Smithies O, Kakoki M

Proceedings of the National Academy of Sciences of the United States of America   113 ( 44 )   12538 - 12543   2016年11月

NF-κB-dependent increase in tissue factor expression is responsible for hypoxic podocyte injury.

Ikuyo Narita, Michiko Shimada, Hideaki Yamabe, Takahiko Kinjo, Tomohiro Tanno, Kimitaka Nishizaki, Misato Kawai, Masayuki Nakamura, Reiichi Murakami, Norio Nakamura, Hirofumi Tomita, Moin A Saleem, Peter W Mathieson, Ken Okumura

Clinical and experimental nephrology   20 ( 5 )   679 - 688   2016年10月

NF-κB-dependent increase in tissue factor expression is responsible for hypoxic podocyte injury.

Narita I, Shimada M, Yamabe H, Kinjo T, Tanno T, Nishizaki K, Kawai M, Nakamura M, Murakami R, Nakamura N, Tomita H, Saleem MA, Mathieson PW, Okumura K

Clinical and experimental nephrology   20 ( 5 )   679 - 688   2016年10月

Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J-RHYTHM Registry.

Eitaro Kodani, Hirotsugu Atarashi, Hiroshi Inoue, Ken Okumura, Takeshi Yamashita, Toshiaki Otsuka, Hirofumi Tomita, Hideki Origasa,

Journal of the American Heart Association   5 ( 9 )   2016年09月

Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J-RHYTHM Registry.

Kodani E, Atarashi H, Inoue H, Okumura K, Yamashita T, Otsuka T, Tomita H, Origasa H, J‐RHYTHM Registry Investigators.

Journal of the American Heart Association   5 ( 9 )   2016年09月

Long Postpacing Interval After Entrainment of Tachycardia Including a Slow Conduction Zone Within the Circuit.

Takahiko Kinjo, Shingo Sasaki, Masaomi Kimura, Shingen Owada, Daisuke Horiuchi, Kenichi Sasaki, Taihei Itoh, Yuji Ishida, Yoshihiro Shoji, Kimitaka Nishizaki, Yuichi Tsushima, Hirofumi Tomita, Ken Okumura

Journal of cardiovascular electrophysiology   27 ( 8 )   923 - 929   2016年08月

Long Postpacing Interval After Entrainment of Tachycardia Including a Slow Conduction Zone Within the Circuit.

Kinjo T, Sasaki S, Kimura M, Owada S, Horiuchi D, Sasaki K, Itoh T, Ishida Y, Shoji Y, Nishizaki K, Tsushima Y, Tomita H, Okumura K

Journal of cardiovascular electrophysiology   27 ( 8 )   923 - 9   2016年08月

Mitochondrial Inhibitory Factor Protein 1 Functions as an Endogenous Inhibitor for Coupling Factor 6.

Misato Kawai, Tomohiro Osanai, Makoto Tanaka, Koji Magota, Hirofumi Tomita, Ken Okumura

Journal of cellular biochemistry   117 ( 7 )   1680 - 1687   2016年07月

Mitochondrial Inhibitory Factor Protein 1 Functions as an Endogenous Inhibitor for Coupling Factor 6.

Kawai M, Osanai T, Tanaka M, Magota K, Tomita H, Okumura K

Journal of cellular biochemistry   117 ( 7 )   1680 - 7   2016年07月

Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression.

Tomohiro Tanno, Hirofumi Tomita, Ikuyo Narita, Takahiko Kinjo, Kimitaka Nishizaki, Hiroaki Ichikawa, Yoshihiro Kimura, Makoto Tanaka, Tomohiro Osanai, Ken Okumura

Journal of cardiovascular pharmacology   67 ( 6 )   503 - 509   2016年06月

Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression.

Tanno T, Tomita H, Narita I, Kinjo T, Nishizaki K, Ichikawa H, Kimura Y, Tanaka M, Osanai T, Okumura K

Journal of cardiovascular pharmacology   67 ( 6 )   503 - 9   2016年06月

Prothrombin time on admission in patients with cardioembolic stroke and intracranial hemorrhage occurring during warfarin treatment in the direct oral anticoagulant era.

Ken Okumura, Joji Hagii, Norifumi Metoki, Shin Saito, Hiroshi Shiroto, Minoru Yasujima, Hirofumi Tomita

Rinsho shinkeigaku = Clinical neurology   56 ( 5 )   309 - 317   2016年05月

Prothrombin time on admission in patients with cardioembolic stroke and intracranial hemorrhage occurring during warfarin treatment in the direct oral anticoagulant era.

Okumura K, Hagii J, Metoki N, Saito S, Shiroto H, Yasujima M, Tomita H

Rinsho shinkeigaku = Clinical neurology   56 ( 5 )   309 - 17   2016年05月

Reduced residual conduction gaps and favourable outcome in contact force-guided circumferential pulmonary vein isolation.

Taihei Itoh, Masaomi Kimura, Hirofumi Tomita, Shingo Sasaki, Shingen Owada, Daisuke Horiuchi, Kenichi Sasaki, Yuji Ishida, Takahiko Kinjo, Ken Okumura

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology   18 ( 4 )   531 - 537   2016年04月

Usefulness of combined CARTO electroanatomical mapping and manifest entrainment in ablating adenosine triphosphate-sensitive atrial tachycardia originating from the atrioventricular node vicinity.

Ken Okumura, Shingo Sasaki, Masaomi Kimura, Daisuke Horiuchi, Kenichi Sasaki, Taihei Itoh, Hirofumi Tomita, Yuji Ishida, Takahiko Kinjo

Journal of Arrhythmia   32 ( 2 )   133 - 140   2016年04月

Reduced residual conduction gaps and favourable outcome in contact force-guided circumferential pulmonary vein isolation.

Itoh T, Kimura M, Tomita H, Sasaki S, Owada S, Horiuchi D, Sasaki K, Ishida Y, Kinjo T, Okumura K

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology   18 ( 4 )   531 - 7   2016年04月

Usefulness of combined CARTO electroanatomical mapping and manifest entrainment in ablating adenosine triphosphate-sensitive atrial tachycardia originating from the atrioventricular node vicinity.

Okumura K, Sasaki S, Kimura M, Horiuchi D, Sasaki K, Itoh T, Tomita H, Ishida Y, Kinjo T

Journal of arrhythmia   32 ( 2 )   133 - 40   2016年04月

Catheter ablation of ventricular arrhythmias arising from the basal septum of the right ventricle: characteristics and significance of junctional rhythm appearing during ablation.

Kenichi Sasaki, Shingo Sasaki, Masaomi Kimura, Daisuke Horiuchi, Taihei Itoh, Yuji Ishida, Takahiko Kinjo, Hirofumi Tomita, Ken Okumura

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   45 ( 2 )   159 - 167   2016年03月

Catheter ablation of ventricular arrhythmias arising from the basal septum of the right ventricle: characteristics and significance of junctional rhythm appearing during ablation.

Sasaki K, Sasaki S, Kimura M, Horiuchi D, Itoh T, Ishida Y, Kinjo T, Tomita H, Okumura K

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   45 ( 2 )   159 - 67   2016年03月

Modified sympathetic nerve regulation in AKAP5-null mice.

Chong Han, Hirofumi Tomita, Takayoshi Ohba, Kimitaka Nishizaki, Yoshiki Ogata, Yasushi Matsuzaki, Daisuke Sawamura, Teruyuki Yanagisawa, Tomohiro Osanai, Tadaatsu Imaizumi, Atsushi Matsubara, Takeshi Adachi, Kyoichi Ono, Ken Okumura, Manabu Murakami

Biochemical and biophysical research communications   469 ( 4 )   897 - 902   2016年01月

Modified sympathetic nerve regulation in AKAP5-null mice.

Han C, Tomita H, Ohba T, Nishizaki K, Ogata Y, Matsuzaki Y, Sawamura D, Yanagisawa T, Osanai T, Imaizumi T, Matsubara A, Adachi T, Ono K, Okumura K, Murakami M

Biochemical and biophysical research communications   469 ( 4 )   897 - 902   2016年01月

Assessment of risk factors for bleeding in Japanese patients with non-valvular atrial fibrillation receiving warfarin treatment: A subanalysis of the J-RHYTHM Registry.

Hirofumi Tomita, Ken Okumura, Hiroshi Inoue, Hirotsugu Atarashi, Takeshi Yamashita, Hideki Origasa,

International journal of cardiology   201   308 - 310   2015年12月

Assessment of risk factors for bleeding in Japanese patients with non-valvular atrial fibrillation receiving warfarin treatment: A subanalysis of the J-RHYTHM Registry.

Tomita H, Okumura K, Inoue H, Atarashi H, Yamashita T, Origasa H, J-RHYTHM Registry Investigators.

International journal of cardiology   201   308 - 10   2015年12月

Enhanced p122RhoGAP/DLC-1 Expression Can Be a Cause of Coronary Spasm.

Takahiko Kinjo, Makoto Tanaka, Tomohiro Osanai, Shuji Shibutani, Ikuyo Narita, Tomohiro Tanno, Kimitaka Nishizaki, Hiroaki Ichikawa, Yoshihiro Kimura, Yuji Ishida, Takashi Yokota, Michiko Shimada, Yoshimi Homma, Hirofumi Tomita, Ken Okumura

PLoS one   10 ( 12 )   e0143884 - e0143884   2015年12月

Impact of Sex Difference on Severity and Functional Outcome in Patients with Cardioembolic Stroke.

Hirofumi Tomita, Joji Hagii, Norifumi Metoki, Shin Saito, Hiroshi Shiroto, Hiroyasu Hitomi, Takaatsu Kamada, Satoshi Seino, Koki Takahashi, Yoshiko Baba, Satoko Sasaki, Takamitsu Uchizawa, Manabu Iwata, Shigeo Matsumoto, Yoshihiro Shoji, Tomohiro Tanno, Tomohiro Osanai, Minoru Yasujima, Ken Okumura

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   24 ( 11 )   2613 - 2618   2015年11月

Impact of Sex Difference on Severity and Functional Outcome in Patients with Cardioembolic Stroke.

Tomita H, Hagii J, Metoki N, Saito S, Shiroto H, Hitomi H, Kamada T, Seino S, Takahashi K, Baba Y, Sasaki S, Uchizawa T, Iwata M, Matsumoto S, Shoji Y, Tanno T, Osanai T, Yasujima M, Okumura K

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   24 ( 11 )   2613 - 8   2015年11月

Severity and Functional Outcome of Patients with Cardioembolic Stroke Occurring during Non-vitamin K Antagonist Oral Anticoagulant Treatment.

Tomita H, Hagii J, Metoki N, Saito S, Shiroto H, Hitomi H, Kamada T, Seino S, Takahashi K, Sasaki S, Yasujima M, Okumura K

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   24 ( 6 )   1430 - 7   2015年06月

Deeply reinverted T wave at 14 days after the onset of first anterior acute myocardial infarction predicts improved left ventricular function at 6 months.

Hiroaki Yokoyama, Hirofumi Tomita, Fumie Nishizaki, Kenji Hanada, Shuji Shibutani, Masahiro Yamada, Naoki Abe, Takumi Higuma, Tomohiro Osanai, Ken Okumura

Clinical cardiology   38 ( 3 )   157 - 163   2015年03月

Deeply reinverted T wave at 14 days after the onset of first anterior acute myocardial infarction predicts improved left ventricular function at 6 months.

Yokoyama H, Tomita H, Nishizaki F, Hanada K, Shibutani S, Yamada M, Abe N, Higuma T, Osanai T, Okumura K

Clinical cardiology   38 ( 3 )   157 - 63   2015年03月

Plasma soluble lectin-like oxidized low-density lipoprotein receptor-1 as a novel prognostic biomarker in patients with ST-segment elevation acute myocardial infarction.

Takumi Higuma, Naoki Abe, Syunta Tateyama, Tomohide Endo, Shuji Shibutani, Hiroaki Yokoyama, Kenji Hanada, Masahiro Yamada, Hirofumi Tomita, Hiroyuki Hanada, Tomohiro Osanai, Noriaki Kume, Ken Okumura

Circulation journal : official journal of the Japanese Circulation Society   79 ( 3 )   641 - 648   2015年02月

Identification of aortic arch-specific quantitative trait loci for atherosclerosis by an intercross of DBA/2J and 129S6 apolipoprotein E-deficient mice.

Yukako Kayashima, Natalia A Makhanova, Kota Matsuki, Hirofumi Tomita, Brian J Bennett, Nobuyo Maeda

PloS one   10 ( 2 )   e0117478 - e0117478   2015年02月

CHA2DS2-VASc and HAS-BLED scores and activated partial thromboplastin time for prediction of high plasma concentration of dabigatran at trough.

Owada S, Tomita H, Kinjo T, Ishida Y, Itoh T, Sasaki K, Horiuchi D, Kimura M, Sasaki S, Okumura K

Thrombosis research   135 ( 1 )   62 - 7   2015年01月

Plasma soluble lectin-like oxidized low-density lipoprotein receptor-1 as a novel prognostic biomarker in patients with ST-segment elevation acute myocardial infarction.

Higuma T, Abe N, Tateyama S, Endo T, Shibutani S, Yokoyama H, Hanada K, Yamada M, Tomita H, Hanada H, Osanai T, Kume N, Okumura K

Circulation journal : official journal of the Japanese Circulation Society   79 ( 3 )   641 - 8   2015年

Enhanced p122RhoGAP/DLC-1 Expression Can Be a Cause of Coronary Spasm.

Kinjo T, Tanaka M, Osanai T, Shibutani S, Narita I, Tanno T, Nishizaki K, Ichikawa H, Kimura Y, Ishida Y, Yokota T, Shimada M, Homma Y, Tomita H, Okumura K

PloS one   10 ( 12 )   e0143884   2015年

Is low body weight a novel risk factor for thromboembolic events in patients with non-valvular atrial fibrillation?

Tomita H, Okumura K

Circulation journal : official journal of the Japanese Circulation Society   79 ( 5 )   960 - 1   2015年

Identification of aortic arch-specific quantitative trait loci for atherosclerosis by an intercross of DBA/2J and 129S6 apolipoprotein E-deficient mice.

Kayashima Y, Makhanova NA, Matsuki K, Tomita H, Bennett BJ, Maeda N

PloS one   10 ( 2 )   e0117478   2015年

Validation of Risk Scoring System Excluding Female Sex From CHA2DS2-VASc in Japanese Patients With Nonvalvular Atrial Fibrillation – Subanalysis of the J-RHYTHM Registry.

Tomita H, Okumura K, Inoue H, Atarashi H, Yamashita T, Origasa H, Tsushima E, J-RHYTHM Registry Investigators.

Circulation journal : official journal of the Japanese Circulation Society   79 ( 8 )   1719 - 26   2015年

Usefulness of the wearable cardioverter-defibrillator in patients at high risk for sudden cardiac death.

Shingo Sasaki, Hirofumi Tomita, Shuji Shibutani, Kei Izumiyama, Takumi Higuma, Taihei Itoh, Kenichi Sasaki, Daisuke Horiuchi, Masaomi Kimura, Ken Okumura

Circulation journal : official journal of the Japanese Circulation Society   78 ( 12 )   2987 - 2989   2014年11月

Low serum eicosapentaenoic acid level is a risk for ventricular arrhythmia in patients with acute myocardial infarction: a possible link to J-waves.

Tomohide Endo, Hirofumi Tomita, Takumi Higuma, Naoki Abe, Motoi Kushibiki, Shin Saitoh, Masahiro Yamada, Takashi Yokota, Takashi Echizen, Hiroaki Yokoyama, Shunta Tateyama, Akiko Suzuki, Yuji Ishida, Kazuo Murakami, Tomohiro Osanai, Ken Okumura

Heart and vessels   29 ( 6 )   847 - 854   2014年11月

Low serum eicosapentaenoic acid level is a risk for ventricular arrhythmia in patients with acute myocardial infarction: a possible link to J-waves.

Endo T, Tomita H, Higuma T, Abe N, Kushibiki M, Saitoh S, Yamada M, Yokota T, Echizen T, Yokoyama H, Tateyama S, Suzuki A, Ishida Y, Murakami K, Osanai T, Okumura K

Heart and vessels   29 ( 6 )   847 - 54   2014年11月

Characteristics of intracerebral hemorrhage during rivaroxaban treatment: comparison with those during warfarin.

Hagii J, Tomita H, Metoki N, Saito S, Shiroto H, Hitomi H, Kamada T, Seino S, Takahashi K, Baba Y, Sasaki S, Uchizawa T, Iwata M, Matsumoto S, Osanai T, Yasujima M, Okumura K

Stroke   45 ( 9 )   2805 - 7   2014年09月

Coupling factor 6 attenuates CXCR4 expression through the HIF-1α and c-Src pathways and promotes endothelial apoptosis and inflammation.

Akiko Suzuki, Tomohiro Osanai, Makoto Tanaka, Hirofumi Tomita, Koji Magota, Ken Okumura

Hypertension research : official journal of the Japanese Society of Hypertension   37 ( 8 )   708 - 715   2014年08月

Coupling factor 6 attenuates CXCR4 expression through the HIF-1α and c-Src pathways and promotes endothelial apoptosis and inflammation.

Suzuki A, Osanai T, Tanaka M, Tomita H, Magota K, Okumura K

Hypertension research : official journal of the Japanese Society of Hypertension   37 ( 8 )   708 - 15   2014年08月

Reduced smoke-like echo and resolved thrombus in the left atrium with rivaroxaban therapy in an acute cardioembolic stroke patient.

Shin Saito, Hirofumi Tomita, Yoshihiro Kimura, Hiroshi Shiroto, Joji Hagii, Norifumi Metoki, Hiroyasu Hitomi, Takaatsu Kamada, Tomohiro Osanai, Ken Okumura, Minoru Yasujima

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   23 ( 6 )   1747 - 1749   2014年07月

Reduced smoke-like echo and resolved thrombus in the left atrium with rivaroxaban therapy in an acute cardioembolic stroke patient.

Saito S, Tomita H, Kimura Y, Shiroto H, Hagii J, Metoki N, Hitomi H, Kamada T, Osanai T, Okumura K, Yasujima M

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   23 ( 6 )   1747 - 9   2014年07月

Imidapril and enalapril similarly inhibit plasma matrix metalloproteinase activities and attenuate left ventricular remodeling in patients with acute myocardial infarction.

Takashi Yokota, Hirofumi Tomita, Yasuhiro Mori, Takeshi Kudo, Hitoshi Hiraga, Naoyuki Suto, Takumi Higuma, Naoki Abe, Hiroyuki Hanada, Tomohiro Osanai, Ken Okumura

Journal of cardiovascular pharmacology   63 ( 6 )   528 - 532   2014年06月

Comparison of lesion formation between contact force-guided and non-guided circumferential pulmonary vein isolation: a prospective, randomized study.

Masaomi Kimura, Shingo Sasaki, Shingen Owada, Daisuke Horiuchi, Kenichi Sasaki, Taihei Itoh, Yuji Ishida, Takahiko Kinjo, Hirofumi Tomita, Ken Okumura

Heart rhythm : the official journal of the Heart Rhythm Society   11 ( 6 )   984 - 991   2014年06月

Long-term native liver fibrosis in biliary atresia: development of a novel scoring system using histology and standard liver tests.

Tomita H, Masugi Y, Hoshino K, Fuchimoto Y, Fujino A, Shimojima N, Ebinuma H, Saito H, Sakamoto M, Kuroda T

Journal of hepatology   60 ( 6 )   1242 - 8   2014年06月

Comparison of lesion formation between contact force-guided and non-guided circumferential pulmonary vein isolation: a prospective, randomized study.

Kimura M, Sasaki S, Owada S, Horiuchi D, Sasaki K, Itoh T, Ishida Y, Kinjo T, Tomita H, Okumura K

Heart rhythm   11 ( 6 )   984 - 91   2014年06月

Imidapril and enalapril similarly inhibit plasma matrix metalloproteinase activities and attenuate left ventricular remodeling in patients with acute myocardial infarction.

Yokota T, Tomita H, Mori Y, Kudo T, Hiraga H, Suto N, Higuma T, Abe N, Hanada H, Osanai T, Okumura K

Journal of cardiovascular pharmacology   63 ( 6 )   528 - 32   2014年06月

Stent malapposition, as a potential mechanism of very late stent thrombosis after bare-metal stent implantation: a case report.

Takumi Higuma, Naoki Abe, Kenji Hanada, Hiroaki Yokoyama, Hirofumi Tomita, Ken Okumura

Cardiovascular revascularization medicine : including molecular interventions   15 ( 3 )   178 - 181   2014年04月

Stent malapposition, as a potential mechanism of very late stent thrombosis after bare-metal stent implantation: a case report.

Higuma T, Abe N, Hanada K, Yokoyama H, Tomita H, Okumura K

Cardiovascular revascularization medicine : including molecular interventions   15 ( 3 )   178 - 81   2014年04月

Quantitative trait loci affecting atherosclerosis at the aortic root identified in an intercross between DBA2J and 129S6 apolipoprotein E-null mice.

Yukako Kayashima, Hirofumi Tomita, Svetlana Zhilicheva, Shinja Kim, Hyung-Suk Kim, Brian J Bennett, Nobuyo Maeda

PloS one   9 ( 2 )   e88274 - e88274   2014年02月

Quantitative trait loci affecting atherosclerosis at the aortic root identified in an intercross between DBA2J and 129S6 apolipoprotein E-null mice.

Kayashima Y, Tomita H, Zhilicheva S, Kim S, Kim HS, Bennett BJ, Maeda N

PloS one   9 ( 2 )   e88274   2014年

Usefulness of the wearable cardioverter-defibrillator in patients at high risk for sudden cardiac death.

Sasaki S, Tomita H, Shibutani S, Izumiyama K, Higuma T, Itoh T, Sasaki K, Horiuchi D, Kimura M, Okumura K

Circulation journal : official journal of the Japanese Circulation Society   78 ( 12 )   2987 - 9   2014年

Validation of CHA₂DS₂-VASc and HAS-BLED scores in Japanese patients with nonvalvular atrial fibrillation: an analysis of the J-RHYTHM Registry.

Okumura K, Inoue H, Atarashi H, Yamashita T, Tomita H, Origasa H, J-RHYTHM Registry Investigators.

Circulation journal : official journal of the Japanese Circulation Society   78 ( 7 )   1593 - 9   2014年

Re-elevation of T-wave from day 2 to day 4 after successful percutaneous coronary intervention predicts chronic cardiac systolic dysfunction in patients with first anterior acute myocardial infarction.

Fumie Nishizaki, Hirofumi Tomita, Hiroaki Yokoyama, Takumi Higuma, Naoki Abe, Akiko Suzuki, Tomohide Endo, Shunta Tateyama, Yuji Ishida, Tomohiro Osanai, Ken Okumura

Heart and vessels   28 ( 6 )   704 - 713   2013年11月

Re-elevation of T-wave from day 2 to day 4 after successful percutaneous coronary intervention predicts chronic cardiac systolic dysfunction in patients with first anterior acute myocardial infarction.

Nishizaki F, Tomita H, Yokoyama H, Higuma T, Abe N, Suzuki A, Endo T, Tateyama S, Ishida Y, Osanai T, Okumura K

Heart and vessels   28 ( 6 )   704 - 13   2013年11月

Acute myocardial infarction caused by a floating thrombus in the ascending aorta: A role of CD34-positive endothelial cells

Fumie Nishizaki, Hirofumi Tomita, Naoki Abe, Masaomi Kimura, Takumi Higuma, Tomohiro Osanai, Sanae Yamauchi, Kazuyuki Daitoku, Ikuo Fukuda, Yoshimasa Kamata, Ken Okumura

Journal of Cardiology Cases   e88 - e90   2013年08月

Acute myocardial infarction caused by a floating thrombus in the ascending aorta: A role of CD34-positive endothelial cells.

Nishizaki F, Tomita H, Abe N, Kimura M, Higuma T, Osanai T, Yamauchi S, Daitoku K, Fukuda I, Kamata Y, Okumura K

Journal of cardiology cases   8 ( 2 )   e88 - e90   2013年08月

Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy.

Takanori Sukekawa, Tomohiro Osanai, Fumie Nishizaki, Norifumi Metoki, Joji Hagii, Takaatsu Kamada, Minoru Yasujima, Hirofumi Tomita, Koji Magota, Ken Okumura

Hypertension research : official journal of the Japanese Society of Hypertension   36 ( 6 )   520 - 527   2013年06月

Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy.

Sukekawa T, Osanai T, Nishizaki F, Metoki N, Hagii J, Kamada T, Yasujima M, Tomita H, Magota K, Okumura K

Hypertension research : official journal of the Japanese Society of Hypertension   36 ( 6 )   520 - 7   2013年06月

Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1.

Masao Kakoki, Oleh M Pochynyuk, Catherine M Hathaway, Hirofumi Tomita, John R Hagaman, Hyung-Suk Kim, Oleg L Zaika, Mykola Mamenko, Yukako Kayashima, Kota Matsuki, Sylvia Hiller, Feng Li, Longquan Xu, Ruriko Grant, Alejandro M Bertorello, Oliver Smithies

Proceedings of the National Academy of Sciences of the United States of America   110 ( 14 )   5600 - 5605   2013年04月

Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1.

Kakoki M, Pochynyuk OM, Hathaway CM, Tomita H, Hagaman JR, Kim HS, Zaika OL, Mamenko M, Kayashima Y, Matsuki K, Hiller S, Li F, Xu L, Grant R, Bertorello AM, Smithies O

Proceedings of the National Academy of Sciences of the United States of America   110 ( 14 )   5600 - 5   2013年04月

Detection of aortic arch calcification in apolipoprotein E-null mice using carbon nanotube-based micro-CT system.

Wait JM, Tomita H, Burk LM, Lu J, Zhou OZ, Maeda N, Lee YZ

Journal of the American Heart Association   2 ( 1 )   e003358   2013年02月

Detection of aortic arch calcification in apolipoprotein E-null mice using carbon nanotube-based micro-CT system.

John M S Wait, Hirofumi Tomita, Laurel M Burk, Jianping Lu, Otto Z Zhou, Nobuyo Maeda, Yueh Z Lee

Journal of the American Heart Association   2 ( 1 )   e003358 - e003358   2013年02月

Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice.

Shigeki Sagara, Tomohiro Osanai, Taihei Itoh, Kei Izumiyama, Shuji Shibutani, Kenji Hanada, Hiroaki Yokoyama, Yuko Yamamoto, Takashi Yokota, Hirofumi Tomita, Koji Magota, Ken Okumura

Journal of hypertension   30 ( 4 )   778 - 786   2012年04月

Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice.

Sagara S, Osanai T, Itoh T, Izumiyama K, Shibutani S, Hanada K, Yokoyama H, Yamamoto Y, Yokota T, Tomita H, Magota K, Okumura K

Journal of hypertension   30 ( 4 )   778 - 86   2012年04月

The kallikrein-kinin system in diabetic nephropathy.

Tomita H, Sanford RB, Smithies O, Kakoki M

Kidney international   81 ( 8 )   733 - 44   2012年04月

Coronary vasospasm induced in transgenic mouse with increased phospholipase C-δ1 activity.

Shibutani S, Osanai T, Ashitate T, Sagara S, Izumiyama K, Yamamoto Y, Hanada K, Echizen T, Tomita H, Fujita T, Miwa T, Matsubara H, Homma Y, Okumura K

Circulation   125 ( 8 )   1027 - 36   2012年02月

Randomized study on the efficacy and safety of landiolol, an ultra-short-acting β1-adrenergic blocker, in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.

Kenji Hanada, Takumi Higuma, Fumie Nishizaki, Takanori Sukekawa, Takashi Yokota, Masahiro Yamada, Shin Saito, Motoi Kushibiki, Koichi Oikawa, Naoki Abe, Hirofumi Tomita, Tomohiro Osanai, Ken Okumura

Circulation journal : official journal of the Japanese Circulation Society   76 ( 2 )   439 - 445   2012年02月

Coupling factor 6-induced activation of ecto-F1F(o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice.

T Osanai, M Tanaka, K Magota, H Tomita, K Okumura

Diabetologia   55 ( 2 )   520 - 529   2012年02月

Relationship between hemodynamics and atherosclerosis in aortic arches of apolipoprotein E-null mice on 129S6/SvEvTac and C57BL/6J genetic backgrounds.

Hirofumi Tomita, John Hagaman, Morton H Friedman, Nobuyo Maeda

Atherosclerosis   220 ( 1 )   78 - 85   2012年01月

Relationship between hemodynamics and atherosclerosis in aortic arches of apolipoprotein E-null mice on 129S6/SvEvTac and C57BL/6J genetic backgrounds.

Tomita H, Hagaman J, Friedman MH, Maeda N

Atherosclerosis   220 ( 1 )   78 - 85   2012年01月

Randomized study on the efficacy and safety of landiolol, an ultra-short-acting β1-adrenergic blocker, in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.

Hanada K, Higuma T, Nishizaki F, Sukekawa T, Yokota T, Yamada M, Saito S, Kushibiki M, Oikawa K, Abe N, Tomita H, Osanai T, Okumura K

Circulation journal : official journal of the Japanese Circulation Society   76 ( 2 )   439 - 45   2012年

Brain natriuretic peptide is released from human astrocytoma cell line U373MG under hypoxia: a possible role in anti-apoptosis.

Chisato Katoh, Tomohiro Osanai, Hirofumi Tomita, Ken Okumura

The Journal of endocrinology   208 ( 1 )   51 - 57   2011年01月

Brain natriuretic peptide is released from human astrocytoma cell line U373MG under hypoxia: a possible role in anti-apoptosis.

Katoh C, Osanai T, Tomita H, Okumura K

The Journal of endocrinology   208 ( 1 )   51 - 7   2011年01月

Effects of telmisartan on markers of ventricular remodeling in patients with acute myocardial infarction: comparison with enalapril.

Takashi Yokota, Tomohiro Osanai, Kenji Hanada, Motoi Kushibiki, Naoki Abe, Koichi Oikawa, Hirofumi Tomita, Takumi Higuma, Jin Yokoyama, Hiroyuki Hanada, Ken Okumura

Heart and vessels   25 ( 6 )   460 - 468   2010年11月

Overexpression of coupling factor 6 causes cardiac dysfunction under high-salt diet in mice.

Toshihiro Ashitate, Tomohiro Osanai, Makoto Tanaka, Koji Magota, Takashi Echizen, Kei Izumiyama, Hiroaki Yokoyama, Shuji Shibutani, Kenji Hanada, Hirofumi Tomita, Ken Okumura

Journal of hypertension   28 ( 11 )   2243 - 2251   2010年11月

Overexpression of coupling factor 6 causes cardiac dysfunction under high-salt diet in mice.

Ashitate T, Osanai T, Tanaka M, Magota K, Echizen T, Izumiyama K, Yokoyama H, Shibutani S, Hanada K, Tomita H, Okumura K

Journal of hypertension   28 ( 11 )   2243 - 51   2010年11月

Effects of telmisartan on markers of ventricular remodeling in patients with acute myocardial infarction: comparison with enalapril.

Yokota T, Osanai T, Hanada K, Kushibiki M, Abe N, Oikawa K, Tomita H, Higuma T, Yokoyama J, Hanada H, Okumura K

Heart and vessels   25 ( 6 )   460 - 8   2010年11月

p122 protein enhances intracellular calcium increase to acetylcholine: its possible role in the pathogenesis of coronary spastic angina.

Reiichi Murakami, Tomohiro Osanai, Hirofumi Tomita, Satoko Sasaki, Atsushi Maruyama, Ken Itoh, Yoshimi Homma, Ken Okumura

Arteriosclerosis, thrombosis, and vascular biology   30 ( 10 )   1968 - 1975   2010年10月

p122 protein enhances intracellular calcium increase to acetylcholine: its possible role in the pathogenesis of coronary spastic angina.

Murakami R, Osanai T, Tomita H, Sasaki S, Maruyama A, Itoh K, Homma Y, Okumura K

Arteriosclerosis, thrombosis, and vascular biology   30 ( 10 )   1968 - 75   2010年10月

Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.

Masao Kakoki, Kelli A Sullivan, Carey Backus, John M Hayes, Sang Su Oh, Kunjie Hua, Adil M H Gasim, Hirofumi Tomita, Ruriko Grant, Sarah B Nossov, Hyung-Suk Kim, J Charles Jennette, Eva L Feldman, Oliver Smithies

Proceedings of the National Academy of Sciences of the United States of America   107 ( 22 )   10190 - 10195   2010年06月

Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.

Kakoki M, Sullivan KA, Backus C, Hayes JM, Oh SS, Hua K, Gasim AM, Tomita H, Grant R, Nossov SB, Kim HS, Jennette JC, Feldman EL, Smithies O

Proceedings of the National Academy of Sciences of the United States of America   107 ( 22 )   10190 - 5   2010年06月

Aortic arch curvature and atherosclerosis have overlapping quantitative trait loci in a cross between 129S6/SvEvTac and C57BL/6J apolipoprotein E-null mice.

Tomita H, Zhilicheva S, Kim S, Maeda N

Circulation research   106 ( 6 )   1052 - 60   2010年04月

Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke: a possible linkage to homocysteine.

Tomohiro Osanai, Naoto Fujiwara, Satoko Sasaki, Norifumi Metoki, Genta Saitoh, Hirofumi Tomita, Takashi Nishimura, Shuji Shibutani, Hiroaki Yokoyama, Yoshiyuki Konta, Koji Magota, Ken Okumura

Annals of medicine   42 ( 1 )   79 - 86   2010年02月

Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke: a possible linkage to homocysteine.

Osanai T, Fujiwara N, Sasaki S, Metoki N, Saitoh G, Tomita H, Nishimura T, Shibutani S, Yokoyama H, Konta Y, Magota K, Okumura K

Annals of medicine   42 ( 1 )   79 - 86   2010年

Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats.

Tomohiro Osanai, Hirofumi Tomita, Masahiro Yamada, Makoto Tanaka, Toshihiro Ashitate, Takashi Echizen, Chisato Katoh, Koji Magota, Ken Okumura

Journal of hypertension   27 ( 9 )   1823 - 1828   2009年09月

Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats.

Osanai T, Tomita H, Yamada M, Tanaka M, Ashitate T, Echizen T, Katoh C, Magota K, Okumura K

Journal of hypertension   27 ( 9 )   1823 - 8   2009年09月

Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells.

Tomohiro Osanai, Hirofumi Tomita, Motoi Kushibiki, Masahiro Yamada, Makoto Tanaka, Toshihiro Ashitate, Takashi Echizen, Chisato Katoh, Koji Magota, Ken Okumura

Cardiovascular research   81 ( 4 )   780 - 787   2009年03月

Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells.

Osanai T, Tomita H, Kushibiki M, Yamada M, Tanaka M, Ashitate T, Echizen T, Katoh C, Magota K, Okumura K

Cardiovascular research   81 ( 4 )   780 - 7   2009年03月

Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in vascular endothelial cells: a role of acidosis-induced c-Src activation.

Takashi Echizen, Tomohiro Osanai, Toshihiro Ashitate, Hiroaki Yokoyama, Shuji Shibutani, Makoto Tanaka, Hirofumi Tomita, Koji Magota, Ken Okumura

Hypertension research : official journal of the Japanese Society of Hypertension   32 ( 3 )   182 - 187   2009年03月

Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in vascular endothelial cells: a role of acidosis-induced c-Src activation.

Echizen T, Osanai T, Ashitate T, Yokoyama H, Shibutani S, Tanaka M, Tomita H, Magota K, Okumura K

Hypertension research : official journal of the Japanese Society of Hypertension   32 ( 3 )   182 - 7   2009年03月

Impact of telmisartan on coronary stenting in patients with acute myocardial infarction compared with enalapril.

Jin Yokoyama, Takumi Higuma, Hirofumi Tomita, Naoki Abe, Koichi Oikawa, Takayuki Fujiwara, Takashi Yokota, Hiroaki Yokoyama, Masaomi Kimura, Shingo Sasaki, Hiroyuki Hanada, Tomohiro Osanai, Ken Okumura

International journal of cardiology   132 ( 1 )   114 - 120   2009年02月

Impact of telmisartan on coronary stenting in patients with acute myocardial infarction compared with enalapril.

Yokoyama J, Higuma T, Tomita H, Abe N, Oikawa K, Fujiwara T, Yokota T, Yokoyama H, Kimura M, Sasaki S, Hanada H, Osanai T, Okumura K

International journal of cardiology   132 ( 1 )   114 - 20   2009年02月

Elevated plasma brain natriuretic peptide levels independent of heart disease in acute ischemic stroke: correlation with stroke severity.

Hirofumi Tomita, Norifumi Metoki, Genta Saitoh, Toshihiro Ashitate, Takashi Echizen, Chisato Katoh, Michitaka Fukuda, Minoru Yasujima, Tomohiro Osanai, Ken Okumura

Hypertension research : official journal of the Japanese Society of Hypertension   31 ( 9 )   1695 - 1702   2008年09月

Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule.

Akiko Kumagai, Tomohiro Osanai, Chisato Katoh, Makoto Tanaka, Hirofumi Tomita, Takeshi Morimoto, Reiichi Murakami, Koji Magota, Ken Okumura

Atherosclerosis   200 ( 1 )   45 - 50   2008年09月

Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule.

Kumagai A, Osanai T, Katoh C, Tanaka M, Tomita H, Morimoto T, Murakami R, Magota K, Okumura K

Atherosclerosis   200 ( 1 )   45 - 50   2008年09月

Elevated plasma brain natriuretic peptide levels independent of heart disease in acute ischemic stroke: correlation with stroke severity.

Tomita H, Metoki N, Saitoh G, Ashitate T, Echizen T, Katoh C, Fukuda M, Yasujima M, Osanai T, Okumura K

Hypertension research : official journal of the Japanese Society of Hypertension   31 ( 9 )   1695 - 702   2008年09月

Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT1) receptor: possible role of AT1 receptor dimerization.

Masahiro Yamada, Motoi Kushibiki, Tomohiro Osanai, Hirofumi Tomita, Ken Okumura

Cardiovascular research   79 ( 1 )   169 - 178   2008年07月

Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT1) receptor: possible role of AT1 receptor dimerization.

Yamada M, Kushibiki M, Osanai T, Tomita H, Okumura K

Cardiovascular research   79 ( 1 )   169 - 78   2008年07月

Aldosterone causes vasoconstriction in coronary arterioles of rats via angiotensin II type-1 receptor: influence of hypertension.

Motoi Kushibiki, Masahiro Yamada, Koichi Oikawa, Hirofumi Tomita, Tomohiro Osanai, Ken Okumura

European journal of pharmacology   572 ( 2-3 )   182 - 188   2007年10月

Aldosterone causes vasoconstriction in coronary arterioles of rats via angiotensin II type-1 receptor: influence of hypertension.

Kushibiki M, Yamada M, Oikawa K, Tomita H, Osanai T, Okumura K

European journal of pharmacology   572 ( 2-3 )   182 - 8   2007年10月

Increased level of pericardial insulin-like growth factor-1 in patients with left ventricular dysfunction and advanced heart failure.

Naoki Abe, Toshiro Matsunaga, Kunihiko Kameda, Hirofumi Tomita, Takayuki Fujiwara, Hiroshi Ishizaka, Hiroyuki Hanada, Kozo Fukui, Ikuo Fukuda, Tomohiro Osanai, Ken Okumura

Journal of the American College of Cardiology   48 ( 7 )   1387 - 1395   2006年10月

Increased level of pericardial insulin-like growth factor-1 in patients with left ventricular dysfunction and advanced heart failure.

Abe N, Matsunaga T, Kameda K, Tomita H, Fujiwara T, Ishizaka H, Hanada H, Fukui K, Fukuda I, Osanai T, Okumura K

Journal of the American College of Cardiology   48 ( 7 )   1387 - 95   2006年10月

Mutational analysis of Kir6.1 in Japanese patients with coronary spastic angina.

Hirofumi Tomita, Satoko Sasaki, Tomohiro Osanai, Takao Nakano, Takumi Higuma, Jin Yokoyama, Hiroyuki Hanada, Minoru Yasujima, Ken Okumura

International journal of molecular medicine   18 ( 4 )   589 - 591   2006年10月

Mutational analysis of Kir6.1 in Japanese patients with coronary spastic angina.

Tomita H, Sasaki S, Osanai T, Nakano T, Higuma T, Yokoyama J, Hanada H, Yasujima M, Okumura K

International journal of molecular medicine   18 ( 4 )   589 - 91   2006年10月

Effect of vasoconstrictor coupling factor 6 on gene expression profile in human vascular endothelial cells: enhanced release of asymmetric dimethylarginine.

Makoto Tanaka, Tomohiro Osanai, Reiichi Murakami, Satoko Sasaki, Hirofumi Tomita, Naotaka Maeda, Kei Satoh, Koji Magota, Ken Okumura

Journal of hypertension   24 ( 3 )   489 - 497   2006年03月

Effect of vasoconstrictor coupling factor 6 on gene expression profile in human vascular endothelial cells: enhanced release of asymmetric dimethylarginine.

Tanaka M, Osanai T, Murakami R, Sasaki S, Tomita H, Maeda N, Satoh K, Magota K, Okumura K

Journal of hypertension   24 ( 3 )   489 - 97   2006年03月

Intracellular signaling for vasoconstrictor coupling factor 6: novel function of beta-subunit of ATP synthase as receptor.

Tomohiro Osanai, Koji Magota, Makoto Tanaka, Michiko Shimada, Reiichi Murakami, Satoko Sasaki, Hirofumi Tomita, Naotaka Maeda, Ken Okumura

Hypertension   46 ( 5 )   1140 - 1146   2005年11月

Intracellular signaling for vasoconstrictor coupling factor 6: novel function of beta-subunit of ATP synthase as receptor.

Osanai T, Magota K, Tanaka M, Shimada M, Murakami R, Sasaki S, Tomita H, Maeda N, Okumura K

Hypertension (Dallas, Tex. : 1979)   46 ( 5 )   1140 - 6   2005年11月

Roxithromycin is an inhibitor of human coronary artery smooth muscle cells proliferation: a potential ability to prevent coronary heart disease.

Hirofumi Tomita, Tomohiro Osanai, Tsutomu Toki, Naotaka Maeda, Reiichi Murakami, Zhaoning Chen, Hideaki Yamabe, Hiroshi Osawa, Minoru Yasujima, Ken Okumura

Atherosclerosis   182 ( 1 )   87 - 95   2005年09月

Roxithromycin is an inhibitor of human coronary artery smooth muscle cells proliferation: a potential ability to prevent coronary heart disease.

Tomita H, Osanai T, Toki T, Maeda N, Murakami R, Chen Z, Yamabe H, Osawa H, Yasujima M, Okumura K

Atherosclerosis   182 ( 1 )   87 - 95   2005年09月

Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells.

Hirofumi Tomita, Tomohiro Osanai, Tsutomu Toki, Satoko Sasaki, Naotaka Maeda, Reiichi Murakami, Koji Magota, Minoru Yasujima, Ken Okumura

Cardiovascular research   67 ( 1 )   134 - 141   2005年07月

Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells.

Tomita H, Osanai T, Toki T, Sasaki S, Maeda N, Murakami R, Magota K, Yasujima M, Okumura K

Cardiovascular research   67 ( 1 )   134 - 41   2005年07月

Tumor necrosis factor alpha as an endogenous stimulator for circulating coupling factor 6.

Satoko Sasaki, Tomohiro Osanai, Hirofumi Tomita, Toshiro Matsunaga, Koji Magota, Ken Okumura

Cardiovascular research   62 ( 3 )   578 - 586   2004年06月

Tumor necrosis factor alpha as an endogenous stimulator for circulating coupling factor 6.

Sasaki S, Osanai T, Tomita H, Matsunaga T, Magota K, Okumura K

Cardiovascular research   62 ( 3 )   578 - 86   2004年06月

Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease.

Tomohiro Osanai, Masayuki Nakamura, Satoko Sasaki, Hirofumi Tomita, Masayuki Saitoh, Hiroshi Osawa, Hideaki Yamabe, Shuichi Murakami, Koji Magota, Ken Okumura

Kidney international   64 ( 6 )   2291 - 2297   2003年12月

Circulating coupling factor 6 in human hypertension: role of reactive oxygen species.

Tomohiro Osanai, Satoko Sasaki, Takaatsu Kamada, Naoto Fujiwara, Takao Nakano, Hirofumi Tomita, Toshiro Matsunaga, Koji Magota, Ken Okumura

Journal of hypertension   21 ( 12 )   2323 - 2328   2003年12月

Circulating coupling factor 6 in human hypertension: role of reactive oxygen species.

Osanai T, Sasaki S, Kamada T, Fujiwara N, Nakano T, Tomita H, Matsunaga T, Magota K, Okumura K

Journal of hypertension   21 ( 12 )   2323 - 8   2003年12月

Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease.

Osanai T, Nakamura M, Sasaki S, Tomita H, Saitoh M, Osawa H, Yamabe H, Murakami S, Magota K, Okumura K

Kidney international   64 ( 6 )   2291 - 7   2003年12月

Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells.

Tomohiro Osanai, Masayuki Saitoh, Satoko Sasaki, Hirofumi Tomita, Toshiro Matsunaga, Ken Okumura

Hypertension   42 ( 5 )   985 - 990   2003年11月

Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells.

Osanai T, Saitoh M, Sasaki S, Tomita H, Matsunaga T, Okumura K

Hypertension (Dallas, Tex. : 1979)   42 ( 5 )   985 - 90   2003年11月

[Relationship between duration of arrhythmia and subsequent preventive effect of disopyramide after cardioversion in patients with symptomatic paroxysmal and persistent atrial fibrillation].

Komatsu T, Yomogida K, Nakamura S, Suzuki O, Horiuchi D, Kameda K, Tomita H, Abe N, Owada S, Oikawa K, Okumura K

Journal of cardiology   42 ( 3 )   111 - 7   2003年09月

[Comparison of the efficacies of disopyramide, cibenzoline and aprindine for the termination of paroxysmal and persistent atrial fibrillation in elderly and non-elderly patients].

Komatsu T, Nakamura S, Suzuki O, Yomogida K, Horiuchi D, Abe N, Kameda K, Owada S, Tomita H, Oikawa K, Okumura K

Journal of cardiology   41 ( 4 )   191 - 8   2003年04月

[Long-term efficacy of combination therapy using antiarrhythmic agents and angiotensin converting enzyme inhibitor in patients with paroxysmal and persistent atrial fibrillation: importance of the timing of administration].

Komatsu T, Nakamura S, Suzuki O, Horiuchi D, Owada S, Kameda K, Tomita H, Oikawa K, Abe N, Okumura K

Journal of cardiology   41 ( 2 )   73 - 80   2003年02月

Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease.

Tomohiro Osanai, Naoto Fujiwara, Masayuki Saitoh, Satoko Sasaki, Hirofumi Tomita, Masayuki Nakamura, Hiroshi Osawa, Hideaki Yamabe, Ken Okumura

Blood purification   20 ( 5 )   466 - 468   2002年05月

Enhanced activity of variant phospholipase C-delta1 protein (R257H) detected in patients with coronary artery spasm.

Takao Nakano, Tomohiro Osanai, Hirofumi Tomita, Masayuki Sekimata, Yoshimi Homma, Ken Okumura

Circulation   105 ( 17 )   2024 - 2029   2002年04月

Enhanced activity of variant phospholipase C-delta1 protein (R257H) detected in patients with coronary artery spasm.

Nakano T, Osanai T, Tomita H, Sekimata M, Homma Y, Okumura K

Circulation   105 ( 17 )   2024 - 9   2002年04月

[Relationship between long-term preventive efficacy of cibenzoline and atrial natriuretic peptide in patients with paroxysmal atrial fibrillation].

Komatsu T, Nakamura S, Kimura M, Owada S, Yomogida K, Kameda K, Oikawa K, Tomita H, Okumura K

Journal of cardiology   39 ( 2 )   93 - 9   2002年02月

Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease.

Osanai T, Fujiwara N, Saitoh M, Sasaki S, Tomita H, Nakamura M, Osawa H, Yamabe H, Okumura K

Blood purification   20 ( 5 )   466 - 8   2002年

標準心臓リハビリテーション：「循環器系の解剖と機能：生理」

富田泰史, 奥村謙（ 担当： 共著）

医歯薬出版株式会社  2013年7月 

リバーロキサバン

富田　泰史, 奥村　謙

脳神経外科速報   27 ( 7 )   729 - 733   2017年7月

Nutritional regulation of coupling factor 6, a novel vasoactive and proatherogenic peptide

Osanai T, Mikami K, Kitajima M, Urushizaka M, Kawasaki K, Tomisawa T, Itaki C, Noto Y, Magota K, Tomita H.

Nutrition   37   74 - 78   2017年5月

循環器疾患におけるDOACの適応と使い方.

富田　泰史

循環器内科   80 ( 3 )   203 - 209   2016年9月

心房細動から脳卒中に至る合併症リスク層別化の開発と重症化予防に向けての治療戦略

富田　泰史

弘前医学   67 ( 1 )   102 - 104   2016年7月

抗血栓療法により頭蓋内出血の特徴に違いがあるか

富田泰史、奥村謙

診断と治療   104 ( 5 )   599 - 603   2016年5月

非ビタミンK阻害経口抗凝固薬(NOAC)のモニタリングは必要か？

萩井譲士、目時典文、白戸弘志、保嶋実、富田泰史、奥村謙

Heart View   20   423 - 429   2016年5月

非弁膜症性心房細動のリスク評価をどう行うか？

富田　泰史

Heart View   20   403 - 409   2016年5月

心房細動と抗血栓薬

富田　泰史, 奥村　謙

血圧   23 ( 1 )   26 - 30   2016年1月

腎デナベーションの降圧レスポンダーの選択

富田　泰史、奥村　謙

Heart View   19   528 - 533   2015年5月

神経節の治療（高血圧）

富田　泰史、奥村　謙

腎臓内科・泌尿器科   1   339 - 345   2015年4月

心房細動の血栓塞栓症リスク・出血リスクの把握

富田　泰史、奥村　謙

カレントテラピー   33   238 - 243   2015年3月

研究の窓辺

富田　泰史

血圧   22   140 - 141   2015年2月

動脈硬化症モデルマウス：脂質異常症マウスを中心として

富田泰史, 前田信代

ファルマシア   45 ( 11 )   1093 - 1097   2009年11月

第31回唐牛記念医学研究基金助成金A

2012年12月

2012年度　武田科学振興財団医学系研究奨励

2012年09月

第24回財団法人持田記念医学薬学振興財団留学助成

2007年10月

第10回弘前大学医学部学術奨励賞

2006年02月

第8回高血圧と動脈硬化研究会部会優秀賞

2003年06月

2023年度，総合教育演習Ⅱ，専門教育科目（学部）

2023年度，臨床実習Ⅰ，専門教育科目（学部）

2023年度，臨床実習Ⅱ，専門教育科目（学部）

2023年度，臨床検査医学，専門教育科目（学部）

2023年度，臨床解剖学，専門教育科目（学部）

2022年度，クリクラⅠ，専門教育科目（学部）

2022年度，クリクラⅡ，専門教育科目（学部）

2022年度，プレBSL，専門教育科目（学部）

2022年度，循環器内科学・外科学Ⅰ，専門教育科目（学部）

2022年度，循環器内科学・外科学Ⅰ（2），専門教育科目（学部）

2022年度，循環器内科学・外科学Ⅱ，専門教育科目（学部）

2022年度，生理学，専門教育科目（学部）

2022年度，臨床検査医学，専門教育科目（学部）

2022年度，臨床解剖学，専門教育科目（学部）

2022年度，ＰＢＬ，専門教育科目（学部）

2021年度，クリクラⅠ，専門教育科目（学部）

2021年度，クリクラⅡ，専門教育科目（学部）

2021年度，プレBSL，専門教育科目（学部）

2021年度，循環器内科学・外科学Ⅰ，専門教育科目（学部）

2021年度，循環器内科学・外科学Ⅱ，専門教育科目（学部）

2021年度，生理学，専門教育科目（学部）

2021年度，研究室研修，専門教育科目（学部）

2021年度，臨床解剖学，専門教育科目（学部）

2021年度，ＰＢＬ，専門教育科目（学部）

2020年度，クリクラⅠ，専門教育科目（学部）

2020年度，クリクラⅡ，専門教育科目（学部）

2020年度，循環器内科学・外科学Ⅰ，専門教育科目（学部）

2020年度，循環器内科学・外科学Ⅱ，専門教育科目（学部）

2020年度，生理学，専門教育科目（学部）

2020年度，研究室研修，専門教育科目（学部）

2020年度，臨床解剖学，専門教育科目（学部）

2020年度，ＰＢＬ，専門教育科目（学部）

2019年度，クリニカルクラークシップ，専門教育科目（学部）

2019年度，プレBSL，専門教育科目（学部）

2019年度，研究室研修，専門教育科目（学部）

2019年度，臨床実習，専門教育科目（学部）

2019年度，臨床解剖学，専門教育科目（学部）

2019年度，ＰＢＬ，専門教育科目（学部）

2018年度，クリニカルクラークシップ，専門教育科目（学部）

2018年度，プレBSL，専門教育科目（学部）

2018年度，循環器内科学・外科学Ⅰ，専門教育科目（学部）

2018年度，循環器内科学・外科学Ⅱ，専門教育科目（学部）

2018年度，研究室研修，専門教育科目（学部）

2018年度，臨床実習，専門教育科目（学部）

2018年度，臨床解剖学，専門教育科目（学部）

2018年度，ＰＢＬ，専門教育科目（学部）

2017年度，クリニカルクラークシップ，専門教育科目（学部）

2017年度，プレBSL，専門教育科目（学部）

2017年度，循環器内科学・外科学Ⅰ，専門教育科目（学部）

2017年度，循環器内科学・外科学Ⅱ，専門教育科目（学部）

2017年度，研究室研修，専門教育科目（学部）

2017年度，臨床実習，専門教育科目（学部）

2017年度，臨床解剖学，専門教育科目（学部）

2016年度，最新医学の現状（Ｐ），21世紀教育科目

2016年度，クリニカルクラークシップ，専門教育科目（学部）

2016年度，プレBSL，専門教育科目（学部）

2016年度，循環器内科学・外科学Ⅰ，専門教育科目（学部）

2016年度，循環器内科学・外科学Ⅱ，専門教育科目（学部）

2016年度，研究室研修，専門教育科目（学部）

2016年度，臨床実習，専門教育科目（学部）

2016年度，臨床解剖学，専門教育科目（学部）

2015年度，クリニカルクラークシップ，専門教育科目（学部）

2015年度，循環器内科・外科学I，専門教育科目（学部）

2015年度，循環器内科・外科学II，専門教育科目（学部）

2015年度，研究室研修，専門教育科目（学部）

2015年度，臨床実習，専門教育科目（学部）

2015年度，臨床解剖学，専門教育科目（学部）

2015年度，医学研究概論II，博士一貫課程・博士後期課程

2014年度，クリニカルクラークシップ，専門教育科目（学部）

2014年度，臨床実習，専門教育科目（学部）

2013年度，クリニカルクラークシップ，専門教育科目（学部）

2013年度，臨床実習，専門教育科目（学部）

2012年度，クリニカルクラークシップ，専門教育科目（学部）

2012年度，臨床実習，専門教育科目（学部）