所属
医学部附属病院 病理部
スズキ トシアキ
鈴木 俊顕
SUZUKI toshiaki
研究分野
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ライフサイエンス / 分子生物学
論文
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Ubiquitin, proteasome and parkin
Tanaka K, Suzuki T, Hattori N, Mizuno Y
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1695 ( 1-3 ) 235 - 247 2004年11月
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A palmitoylated RING finger ubiquitin ligase and its homologue in the brain membranes.
Araki K, Kawamura M, Suzuki T, Matsuda N, Kanbe D, Ishii K, Ichikawa T, Chiba T, Tanaka K, Nawa H
J Neurochem. Aug;86(3) ( 3 ) 749 - 762 2003年12月
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Parkin Mutations (Park 2)
Yoshikuni Mizuno, Nobutaka Hattori, Hiroyo Yoshino, Shiuchi Asakawa, Shinsei Minoshima, Nobuyoshi Shimizu, Toshiaki Suzuki, Tomoki Chiba, Keiji Tanaka
Genetics of Movement Disorders 305 - 314 2003年
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E3 ubiquitin ligase that recognizes sugar chains
Yoshida Y, Chiba T, Tokunaga F, Kawasaki H, Iwai K, Suzuki T, Ito Y, Matsuoka K, Yoshida M, Tanaka K, Tai T
NATURE 418 ( 6896 ) 438 - 442 2002年07月
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Akt enhances Mdm2-mediated ubiquitination and degradation of p53
Ogawara Y, Kishishita S, Obata T, Isazawa Y, Suzuki T, Tanaka K, Masuyama N, Gotoh Y
JOURNAL OF BIOLOGICAL CHEMISTRY 277 ( 24 ) 21843 - 21850 2002年06月
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Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of β-catenin
Kadoya T, Yamamoto H, Suzuki T, Yukita A, Fukui A, Michiue T, Asahara T, Tanaka K, Asashima M, Kikuchi A
MOLECULAR AND CELLULAR BIOLOGY 22 ( 11 ) 3803 - 3819 2002年06月
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Etiology, pathogenesis, and genetics of Parkinson's disease
Y Mizuno, N Hattori, H Shimura, T Kitada, S Kubo, M Wang, K Sato, T Suzuki, T Chiba, K Tanaka, S Asakawa, S Minoshima, N Shimizu
MAPPING THE PROGRESS OF ALZHEIMER'S AND PARKINSON'S DISEASE 51 239 - 244 2002年
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Ubiquitin-proteasome pathway is a key to understanding of nigral degeneration in autosomal recessive juvenile Parkinson's disease
N Hattori, S Asakawa, H Shimura, S Kubo, K Sato, T Kitami, Y Chikaoka-Kwamura, Y Imai, R Takahashi, T Suzuki, K Tanaka, N Shimizu, Y Mizuno
MAPPING THE PROGRESS OF ALZHEIMER'S AND PARKINSON'S DISEASE 51 291 - 296 2002年
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Anti-atherogenic Antioxidants Regulate the Expression and Function of Proteasome α-Type Subunits in Human Endothelial Cells
Wakako Takabe, Tatsuhiko Kodama, Takao Hamakubo, Keiji Tanaka, Toshiaki Suzuki, Hiroyuki Aburatani, Naeko Matsukawa, Noriko Noguchi
Journal of Biological Chemistry 276 ( 44 ) 40497 - 40501 2001年11月
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Parkin is linked to the ubiquitin pathway
K Tanaka, T Suzuki, T Chiba, H Shimura, N Hattori, Y Mizuno
JOURNAL OF MOLECULAR MEDICINE-JMM 79 ( 9 ) 482 - 494 2001年09月
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NEDD8 recruits E2-ubiquitin to SCF E3 ligase
T Kawakami, T Chiba, T Suzuki, K Iwai, K Yamanaka, N Minato, H Suzuki, N Shimbara, Y Hidaka, F Osaka, M Omata, K Tanaka
EMBO JOURNAL 20 ( 15 ) 4003 - 4012 2001年08月
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Parkin and Parkinson's disease
Y Mizuno, N Hattori, H Mori, T Suzuki, K Tanaka
CURRENT OPINION IN NEUROLOGY 14 ( 4 ) 477 - 482 2001年08月
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Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme, in rat brain
M Wang, T Suzuki, T Kitada, S Asakawa, S Minoshima, N Shimizu, K Tanaka, Y Mizuno, N Hattori
JOURNAL OF NEUROCHEMISTRY 77 ( 6 ) 1561 - 1568 2001年06月
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Rma1, a novel type of RING finger protein conserved from <i>Arabidopsis</i> to human, is a membrane-bound ubiquitin ligase
Matsuda N, Suzuki T, Tanaka K, Nakano A
JOURNAL OF CELL SCIENCE 114 ( 10 ) 1949 - 1957 2001年05月
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Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase
N Matsuda, T Suzuki, K Tanaka, A Nakano
JOURNAL OF CELL SCIENCE 114 ( 10 ) 1949 - 1957 2001年05月
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A novel centrosomal RING-finger protein, Dorfin, mediates ubiquitin ligase activity
Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 281 ( 3 ) 706 - 713 2001年03月
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Autosomal recessive juvenile parkinsonism: A key to understanding nigral degeneration in sporadic Parkinson's disease
N Hattori, H Shimura, S Kubo, T Kitada, M Wang, S Asakawa, S Minashima, N Shimizu, T Suzuki, K Tanaka, Y Mizuno
NEUROPATHOLOGY 20 S85 - S90 2000年09月
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Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast
F Osaka, M Saeki, S Katayama, N Aida, A Toh-e, K Kominami, T Toda, T Suzuki, T Chiba, K Tanaka, S Kato
EMBO JOURNAL 19 ( 13 ) 3475 - 3484 2000年07月
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Tissue-specificity, functional characterization and subcellular localization of a rat ubiquitin-specific processing protease, UBP109, whose mRNA expression is developmentally regulated
KC Park, EJ Choi, SW Min, SS Chung, H Kim, T Suzuki, K Tanaka, CH Chung
BIOCHEMICAL JOURNAL 349 ( Pt 2 ) 443 - 453 2000年07月
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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
H Shimura, N Hattori, S Kubo, Y Mizuno, S Asakawa, S Minoshima, N Shimizu, K Iwai, T Chiba, K Tanaka, T Suzuki
NATURE GENETICS 25 ( 3 ) 302 - 305 2000年07月
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A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs
KI Kim, SH Baek, YJ Jeon, S Nishimori, T Suzuki, S Uchida, N Shimbara, H Saitoh, K Tanaka, CH Chung
JOURNAL OF BIOLOGICAL CHEMISTRY 275 ( 19 ) 14102 - 14106 2000年05月
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Homodimer of two F-box proteins beta TrCP1 or beta TrCP2 binds to I kappa B alpha for signal-dependent ubiquitination
H Suzuki, T Chiba, T Suzuki, T Fujita, T Ikenoue, M Omata, K Furuichi, H Shikama, K Tanaka
JOURNAL OF BIOLOGICAL CHEMISTRY 275 ( 4 ) 2877 - 2884 2000年01月
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Autosomal recessive juvenile parkinsonism: Its pathogenesis is involved in the ubiquitin-proteasome pathway
N. Hattori, H. Shimura, S. I. Kubo, T. Suzuki, K. Tanaka, Y. Mizuno
Clinical Neurology 40 ( 12 ) 1293 - 1296 2000年
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A new 30-kDa ubiquitin-related SUMO-1 hydrolase from bovine brain
T Suzuki, A Ichiyama, H Saitoh, T Kawakami, M Omata, CH Chung, M Kimura, N Shimbara, K Tanaka
JOURNAL OF BIOLOGICAL CHEMISTRY 274 ( 44 ) 31131 - 31134 1999年10月
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Isolation and characterization of cytosolic and membrane-bound deubiquitinylating enzymes from bovine brain
T Kawakami, T Suzuki, SH Baek, CH Chung, H Kawasaki, H Hirano, A Ichiyama, M Omata, K Tanaka
JOURNAL OF BIOCHEMISTRY 126 ( 3 ) 612 - 623 1999年09月
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IκBα ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, βTrCP1 and βTrCP2
Suzuki H, Chiba T, Kobayashi M, Takeuchi M, Suzuki T, Ichiyama A, Ikenoue T, Omata M, Furuichi K, Tanaka K
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 256 ( 1 ) 127 - 132 1999年03月
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I kappa B alpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, beta TrCP1 and beta TrCP2
H Suzuki, T Chiba, M Kobayashi, M Takeuchi, T Suzuki, A Ichiyama, T Ikenoue, M Omata, K Furuichi, K Tanaka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 256 ( 1 ) 127 - 132 1999年03月
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Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease
T Fujiwara, A Saito, M Suzuki, H Shinomiya, T Suzuki, E Takahashi, A Tanigami, A Ichiyama, CH Chung, Y Nakamura, K Tanaka
GENOMICS 54 ( 1 ) 155 - 158 1998年11月
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The ligation systems for ubiquitin and ubiquitin-like proteins
K Tanaka, T Suzuki, T Chiba
MOLECULES AND CELLS 8 ( 5 ) 503 - 512 1998年10月
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Energy-dependent degradation of a mutant serine: Pyruvate alanin: Glyoxylate aminotransferase in a primary hyperoxaluria type 1 case
T Suzuki, K Nishiyama, T Funai, K Tanaka, A Ichihara, A Ichiyama
INTRACELLULAR PROTEIN CATABOLISM 389 137 - 140 1996年
総説・短報・翻訳等
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Diverse effects of the pathogenic mutations of parkin that catalyze multiple mono-ubiquitylation
N Matsuda, T Kitami, T Suzuki, Y Mizuno, N Hattori, K Tannaka
MOVEMENT DISORDERS 21 S65 - S65 2006年
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Recombinant sole Parkin catalyzes multiple mono-ubiquitylation and its ubiquitin ligase activity is not abrogated by most of the pathogenic missense mutations
Noriyuki Matsuda, Toshiaki Kitami, Toshiaki Suzuki, Yoshikuni Mizuno, Nobutaka Hattori, Keiji Tanaka
CELL STRUCTURE AND FUNCTION 30 99 - 99 2005年6月
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パーキンソン病におけるプロテアソームの細胞内分布の検討(平成14年度順天堂大学 老人性疾患病態・治療研究センター研究発表会)
色井 淳子, 高梨 雅史, 服部 信孝, 水野 美邦, 鈴木 俊顕, 田中 啓二
順天堂医学 49 ( 3 ) 375 - 376 2003年9月
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パーキンソン病におけるプロテアソームの細胞内分布の検討(平成13年度順天堂大学老人性疾患病態・治療研究センター発表会抄録)
色井 淳子, 服部 信孝, 高梨 雅史, 久保 紳一郎, 水野 美邦, 鈴木 俊顕, 田中 啓二
順天堂医学 48 ( 3 ) 419 - 419 2002年12月
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細胞生物学講座 ユビキチンリガーゼParkinと黒質神経細胞死
北見 聡章, 鈴木 俊顕, 服部 信孝
細胞 34 ( 8 ) 330 - 333 2002年7月
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Parkin ubiquitination activity in vitro: From a study using CDCrel-I
T Kitami, K Sato, T Suzuki, N Hattori, K Tanaka, Y Mizuno
MOVEMENT DISORDERS 17 S153 - S153 2002年
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ユビキチンリガーゼとしてのparkinとParkinson病--家族性Parkinson病から孤発型Parkinson病へ (〔2001年8月〕第1土曜特集 神経疾患の分子医学) -- (神経変性疾患)
服部 信孝, 鈴木 俊顕, 高橋 良輔
医学のあゆみ 198 ( 5 ) 383 - 388 2001年8月
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ユビキチン類似タンパク質(SUMO-1とRub1)細胞機能を制御する新しい修飾分子 (特集 ユビキチンシステムと癌)
鈴木 俊顕, 高橋 芳充, 田中 克典
モレキュラ-メディシン 37 ( 2 ) 216 - 227 2000年2月