Updated on 2022/03/25

写真a

 
HAGIHARA Masaki
 
Affiliation
Shizen Kagakukei(It is currently under consideration) Materials Science and Technology Section
Full-time staff
Graduate School of Science and Technology Research Division

Degree

  • 博士(エネルギー科学)

Research Interests

  • Bioorganic Chemistry

  • Nucleic Acids Chemistry

  • ケミカルバイオロジー

  • グアニン四重鎖

  • antisense

  • RNA

Research Areas

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules

  • Nanotechnology/Materials / Bio chemistry

Professional Memberships

  • 日本薬学会

  • 日本ケミカルバイオロジー学会

  • 日本化学会

  • THE CHEMICAL SOCIETY OF JAPAN

  • JAPANESE SOCIETY FOR CHEMICAL BIOLOGY

Papers

  • Short Tandem Repeat Contractions during In Vitro DNA Synthesis by Repeat-binding Molecules

    Hagihara Masaki, Dohno Chikara, Saito Kaoru, Sugimoto Kazuhiro, Hishinuma Yuta, Sohma Yuri, Shibata Tomonori, Nakatani Kazuhiko

    Chemistry Letters   50 ( 11 )   1848 - 1851   2021.11

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    CiNii Research

  • Guanine-tethered Oligonucleotides Restore Abnormal Protein Synthesis with a SNP Mutation in a 5′-UTR G-quadruplex of Human MSH2

    Hagihara Masaki, Shiroto Shuhei, Igarashi Shunya, Sato Shin-ichi

    Chemistry Letters   50 ( 10 )   1806 - 1809   2021.10

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    CiNii Research

  • Inhibition of protein synthesis through RNA-based tandem G-quadruplex formation.

    Hagihara M

    Chemical communications (Cambridge, England)   57 ( 65 )   8063 - 8066   2021.8

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  • Small molecule-induced trinucleotide repeat contractions during in vitro DNA synthesis.

    Chikara Dohno, Masaki Hagihara, Nursakinah Binti Mohd Zaifuddin, Mizuki Nihei, Kaoru Saito, Kazuhiko Nakatani

    Chemical communications (Cambridge, England)   57 ( 26 )   3235 - 3238   2021.3

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  • Structures and Catalytic Activities of Complexes between Heme and All Parallel-Stranded Monomeric G-Quadruplex DNAs

    Yasuhiko Yamamoto, Haruka Araki, Ryosuke Shinomiya, Kosuke Hayasaka, Yusaku Nakayama, Kentaro Ochi, Tomokazu Shibata, Atsuya Momotake, Takako Ohyama, Masaki Hagihara, and Hikaru Hemmi

    Biochemistry   57 ( 41 )   5938 - 5948   2018.9

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  • Structures and Catalytic Activities of Complexes between Heme and All Parallel-Stranded Monomeric G‐Quadruplex DNAs

    Yasuhiko Yamamoto, Haruka Araki, Ryosuke Shinomiya, Kosuke Hayasaka, Yusaku Nakayama, Kentaro Ochi, Tomokazu Shibata, Atsuya Momotake, Takako Ohyama, Masaki Hagihara, Hikaru Hemmi

    Biochemistry, in press   2018

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  • A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA

    Yousuke Katsuda, Shin-ichi Sato, Lisa Asano, Yoshitaka Morimura, Tomoyuki Furuta, Hiroshi Sugiyama, Masaki Hagihara, Motonari Uesugi

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   138 ( 29 )   9037 - 9040   2016.7

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  • G-Quadruplex DNA- and RNA-Specific-Binding Proteins Engineered from the RGG Domain of TLS/FUS

    Kentaro Takahama, Arisa Miyawaki, Takumi Shitara, Keita Mitsuya, Masayuki Morikawa, Masaki Hagihara, Katsuhito Kino, Ayumu Yamamoto, Takanori Oyoshi

    ACS CHEMICAL BIOLOGY   10 ( 11 )   2564 - 2569   2015.11

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  • Recognition of Chelerythrine to Human Telomeric DNA and RNA G-quadruplexes

    Li-Ping Bai, Masaki Hagihara, Kazuhiko Nakatani, Zhi-Hong Jiang

    Scientific Reports   2014.10

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  • Recognition of Chelerythrine to Human Telomeric DNA and RNA G-quadruplexes

    Li-Ping Bai, Masaki Hagihara, Kazuhiko Nakatani, Zhi-Hong Jiang

    SCIENTIFIC REPORTS   4   6767   2014.10

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  • Formation of a Ligand- Assisted Complex of Two RNA Hairpin Loops

    Changfeng Hong, Takahiro Otabe, Saki Matsumoto, Chikara Dohno, Asako Murata, Masaki Hagihara, Kazuhiko Nakatani

    CHEMISTRY-A EUROPEAN JOURNAL   20 ( 18 )   5282 - 5287   2014.4

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  • Formation of Ligand-Assisted Complex of Two RNA Hairpin Loops

    Changfeng Hong, Takahiro Otabe, Saki Matsumoto, Chikara Dohno, Asako Murata, Masaki Hagihara, and Kazuhiko Nakatani

    Chemistry European Journal   2014.3

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  • Guanine-tethered antisense oligonucleotides as synthetic riboregulators.

    Hagihara M

    Methods in molecular biology (Clifton, N.J.)   1111   197 - 207   2014

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  • A Synthetic Riboswitch that Operates using a Rationally Designed Ligand-RNA Pair.

    Chikara Dohno, Izumi Kohyama, Maki Kimura, Masaki Hagihara, Kazuhiko Nakatani

    Angewandte Chemie (International ed. in English)   52 ( 38 )   9976 - 9979   2013.9

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  • A Synthetic Riboswitch that Operates using a Rationally Designed Ligand-RNA Pair

    Chikara Dohno, Izumi Kohyama, Maki Kimura, Masaki Hagihara, Kazuhiko Nakatani

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   52 ( 38 )   9976 - 9979   2013.9

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  • Activation of prokaryotic translation by antisense oligonucleotides binding to coding region of mRNA.

    Gosuke Hayashi, Changfeng Hong, Masaki Hagihara, Kazuhiko Nakatani

    Biochemical and biophysical research communications   429 ( 1-2 )   105 - 110   2012.12

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  • Activation of prokaryotic translation by antisense oligonucleotides binding to coding region of mRNA

    Gosuke Hayashi, Changfeng Hong, Masaki Hagihara, Kazuhiko Nakatani

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   429 ( 1-2 )   105 - 110   2012.12

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  • Assembly of a Small DNA Rectangular Parallelepiped Block into Higher Order Nanostructures.

    Hiroki Nakagawa, Mariko Toda, Hiroshi Atsumi, Masaki Hagihara, Mitsuko Hayashi-Nishino, Chikara Dohno, Kazuhiko Nakatani

    Chemistry Letters   2012.11

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  • Assembly of a Small DNA Rectangular Parallelepiped Block into Higher Order Nanostructures

    Hiroyuki Nakagawa, Mariko Toda, Hiroshi Atsumi, Masaki Hagihara, Mitsuko Hayashi-Nishino, Chikara Dohno, Kazuhiko Nakatani

    CHEMISTRY LETTERS   41 ( 11 )   1550 - 1552   2012.11

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  • Structure-activity studies on the fluorescent indicator in a displacement assay for the screening of small molecules binding to RNA.

    Shiori Umemoto, Seongwang Im, Jinhua Zhang, Masaki Hagihara, Asako Murata, Yasue Harada, Takeo Fukuzumi, Takahiro Wazaki, Shin-ichi Sasaoka, Kazuhiko Nakatani

    Chemistry (Weinheim an der Bergstrasse, Germany)   18 ( 32 )   9999 - 10008   2012.8

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  • Structure-Activity Studies on the Fluorescent Indicator in a Displacement Assay for the Screening of Small Molecules Binding to RNA

    Shiori Umemoto, Seongwang Im, Jinhua Zhang, Masaki Hagihara, Asako Murata, Yasue Harada, Takeo Fukuzumi, Takahiro Wazaki, Shin-ichi Sasaoka, Kazuhiko Nakatani

    CHEMISTRY-A EUROPEAN JOURNAL   18 ( 32 )   9999 - 10008   2012.8

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  • A small molecule regulates hairpin structures in d(CGG) trinucleotide repeats.

    Masaki Hagihara, Hanping He, Maki Kimura, Kazuhiko Nakatani

    Bioorganic & medicinal chemistry letters   22 ( 5 )   2000 - 2003   2012.3

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  • A small molecule regulates hairpin structures in d(CGG) trinucleotide repeats

    Masaki Hagihara, Hanping He, Maki Kimura, Kazuhiko Nakatani

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   22 ( 5 )   2000 - 2003   2012.3

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  • Small molecule modulates hairpin structures in CAG trinucleotide repeats.

    Masaki Hagihara, Hanping He, Kazuhiko Nakatani

    Chembiochem : a European journal of chemical biology   12 ( 11 )   1686 - 1689   2011.7

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  • Small Molecule Modulates Hairpin Structures in CAG Trinucleotide Repeats

    Masaki Hagihara, Hanping He, Kazuhiko Nakatani

    CHEMBIOCHEM   12 ( 11 )   1686 - 1689   2011.7

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  • Ligand-assisted complex formation of two DNA hairpin loops.

    Changfeng Hong, Masaki Hagihara, Kazuhiko Nakatani

    Angewandte Chemie (International ed. in English)   50 ( 19 )   4390 - 4393   2011.5

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  • Ligand-Assisted Complex Formation of Two DNA Hairpin Loops

    Changfeng Hong, Masaki Hagihara, Kazuhiko Nakatani

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   50 ( 19 )   4390 - 4393   2011

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  • Antisense-induced guanine quadruplexes inhibit reverse transcription by HIV-1 reverse transcriptase.

    Masaki Hagihara, Lisa Yamauchi, Akiko Seo, Keisuke Yoneda, Mayo Senda, Kazuhiko Nakatani

    Journal of the American Chemical Society   132 ( 32 )   11171 - 11178   2010.8

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  • Antisense-Induced Guanine Quadruplexes Inhibit Reverse Transcription by HIV-1 Reverse Transcriptase

    Masaki Hagihara, Lisa Yamauchi, Akiko Seo, Keisuke Yoneda, Mayo Senda, Kazuhiko Nakatani

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   132 ( 32 )   11171 - 11178   2010.8

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  • A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA.

    Masaki Hagihara, Keisuke Yoneda, Hiroaki Yabuuchi, Yasushi Okuno, Kazuhiko Nakatani

    Bioorganic & medicinal chemistry letters   20 ( 7 )   2350 - 2353   2010.4

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  • A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA

    Masaki Hagihara, Keisuke Yoneda, Hiroaki Yabuuchi, Yasushi Okuno, Kazuhiko Nakatani

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   20 ( 7 )   2350 - 2353   2010.4

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  • A small molecule affecting the replication of trinucleotide repeat d(GAA)n.

    Hanping He, Masaki Hagihara, Kazuhiko Nakatani

    Chemistry (Weinheim an der Bergstrasse, Germany)   15 ( 40 )   10641 - 10648   2009.10

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  • RNA aptamers that reversibly bind photoresponsive azobenzene-containing peptides.

    Gosuke Hayashi, Masaki Hagihara, Kazuhiko Nakatani

    Chemistry (Weinheim an der Bergstrasse, Germany)   15 ( 2 )   424 - 432   2009.6

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  • Secondary-structure-inducible ligand fluorescence coupled with PCR.

    Fumie Takei, Masako Igarashi, Masaki Hagihara, Yoshimi Oka, Yoshihiro Soya, Kazuhiko Nakatani

    Angewandte Chemie (International ed. in English)   48 ( 42 )   7822 - 7824   2009.6

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  • Unstable tandem repeats in promoters confer transcriptional evolvability.

    Marcelo D Vinces, Matthieu Legendre, Marina Caldara, Masaki Hagihara, Kevin J Verstrepen

    Science (New York, N.Y.)   324 ( 5931 )   1213 - 1216   2009.5

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  • Unstable Tandem Repeats in Promoters Confer Transcriptional Evolvability

    Marcelo D. Vinces, Matthieu Legendre, Marina Caldara, Masaki Hagihara, Kevin J. Verstrepen

    SCIENCE   324 ( 5931 )   1213 - 1216   2009.5

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  • Secondary-Structure-Inducible Ligand Fluorescence Coupled with PCR

    Fumie Takei, Masako Igarashi, Masaki Hagihara, Yoshimi Oka, Yoshihiro Soya, Kazuhiko Nakatani

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   48 ( 42 )   7822 - 7824   2009

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  • RNA Aptamers That Reversibly Bind Photoresponsive Azobenzene-Containing Peptides

    Gosuke Hayashi, Masaki Hagihara, Kazuhiko Nakatani

    CHEMISTRY-A EUROPEAN JOURNAL   15 ( 2 )   424 - 432   2009

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  • A Small Molecule Affecting the Replication of Trinucleotide Repeat d(GAA)(n)

    Hanping He, Masaki Hagihara, Kazuhiko Nakatani

    CHEMISTRY-A EUROPEAN JOURNAL   15 ( 40 )   10641 - 10648   2009

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  • Ligand binding to tandem G quadruplexes from human telomeric DNA.

    Li-Ping Bai, Masaki Hagihara, Zhi-Hong Jiang, Kazuhiko Nakatani

    Chembiochem : a European journal of chemical biology   9 ( 16 )   2583 - 2587   2008.11

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  • Ligand Binding to Tandem G Quadruplexes from Human Telomeric DNA

    Li-Ping Bai, Masaki Hagihara, Zhi-Hong Jiang, Kazuhiko Nakatani

    CHEMBIOCHEM   9 ( 16 )   2583 - 2587   2008.11

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  • DNA labeling by ligand inducible secondary structure.

    Tao Peng, Hanping He, Masaki Hagihara, Kazuhiko Nakatani

    Chembiochem : a European journal of chemical biology   9 ( 12 )   1893 - 1897   2008.8

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  • DNA labeling by ligand inducible secondary structure

    Tao Peng, Hanping He, Masaki Hagihara, Kazuhiko Nalkatani

    CHEMBIOCHEM   9 ( 12 )   1893 - 1897   2008.8

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  • Context-dependent fluorescence detection of a phosphorylated tyrosine residue by a ribonucleopeptide.

    Tetsuya Hasegawa, Masaki Hagihara, Masatora Fukuda, Shun Nakano, Nobutaka Fujieda, Takashi Morii

    Journal of the American Chemical Society   130 ( 27 )   8804 - 8812   2008.7

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  • Context-dependent fluorescence detection of a phosphorylated tyrosine residue by a ribonucleopeptide

    Tetsuya Hasegawa, Masaki Hagihara, Masatora Fukuda, Shun Nakano, Nobutaka Fujieda, Takashi Morii

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   130 ( 27 )   8804 - 8812   2008.7

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  • Genotyping by allele-specific L-DNA-tagged PCR.

    Gosuke Hayashi, Masaki Hagihara, Kazuhiko Nakatani

    Journal of biotechnology   135 ( 2 )   157 - 160   2008.6

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  • Genotyping by allele-specific L-DNA-tagged PCR

    Gosuke Hayashi, Masaki Hagihara, Kazuhiko Nakatani

    JOURNAL OF BIOTECHNOLOGY   135 ( 2 )   157 - 160   2008.6

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  • Ligand-stabilized hairpin structures interfere with elongation of human telomere.

    Masaki Hagihara, Yuki Goto, Kazuhiko Nakatani

    Chembiochem : a European journal of chemical biology   9 ( 4 )   510 - 513   2008.3

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  • RNA aptamers that reversibly bind to photoresponsive peptide.

    Hayashi G, Hagihara M, Nakatani K

    Nucleic acids symposium series (2004)   ( 52 )   703 - 4   2008

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  • Ligand-Stabilized Hairpin Structures Interfered with Elongation of Human Telomere

    Masaki Hagihara, Yuki Goto, Kazuhiko Nakatani

    ChemBioChem 2008, 9, 510-513   9 ( 4 )   510 - 3   2008

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  • Photoregulation of a peptide-RNA interaction on a gold surface.

    Gosuke Hayashi, Masaki Hagihara, Chikara Dohno, Kazuhiko Nakatani

    Journal of the American Chemical Society   129 ( 28 )   8678 - 8679   2007.7

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  • Photoregulation of a peptide-RNA interaction on a gold surface

    Gosuke Hayashi, Masaki Hagihara, Chikara Dohno, Kazuhiko Nakatani

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   129 ( 28 )   8678 - +   2007.7

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  • Allele specific C-bulge probes with one unique fluorescent molecule discriminate the single nucleotide polymorphism in DNA.

    Fumie Takei, Hitoshi Suda, Masaki Hagihara, Jinhua Zhang, Akio Kobori, Kazuhiko Nakatani

    Chemistry (Weinheim an der Bergstrasse, Germany)   13 ( 16 )   4452 - 4457   2007.6

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  • Stepwise functionalization of ribonucleopeptides: optimization of the response of fluorescent ribonucleopeptide sensors for ATP.

    Tetsuya Hasegawa, Masaki Hagihara, Masatora Fukuda, Takashi Morii

    Nucleosides, nucleotides & nucleic acids   26 ( 10-12 )   1277 - 1281   2007.6

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  • Small-molecule binding to the nonquadruplex form of the human telomeric sequence.

    Yuki Goto, Shinya Hagihara, Masaki Hagihara, Kazuhiko Nakatani

    Chembiochem : a European journal of chemical biology   8 ( 7 )   723 - 726   2007.5

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  • Small-molecule binding to the nonquadruplex form of the human telomeric sequence

    Yuki Goto, Shinya Hagihara, Masaki Hagihara, Kazuhiko Nakatani

    CHEMBIOCHEM   8 ( 7 )   723 - 726   2007.5

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  • Detection of L-DNA-tagged PCR products by surface plasmon resonance imaging.

    Gosuke Hayashi, Masaki Hagihara, Akio Kobori, Kazuhiko Nakatani

    Chembiochem : a European journal of chemical biology   8 ( 2 )   169 - 171   2007.1

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  • Detection of L-DNA-tagged PCR products by surface plasmon resonance imaging

    Gosuke Hayashi, Masaki Hagihara, Akio Kobori, Kazuhiko Nakatani

    CHEMBIOCHEM   8 ( 2 )   169 - 171   2007.1

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  • Stepwise functionalization of ribonucleopeptides: Optimization of the response of fluorescent ribonucleopeptide sensors for ATP

    Tetsuya Hasegawa, Masaki Hagihara, Masatora Fukuda, Takashi Morii

    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS   26 ( 10-12 )   1277 - 1281   2007

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  • Reversible regulation of binding between a photoresponsive peptide and its RNA aptamer.

    Hayashi G, Hagihara M, Dohno C, Nakatani K

    Nucleic acids symposium series (2004)   ( 51 )   93 - 4   2007

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  • Allele specific C-bulge probes with one unique fluorescent molecule discriminate the single nucleotide polymorphism in DNA

    Fumie Takei, Hitoshi Suda, Masaki Hagihara, Jinhua Zhang, Akio Kobori, Kazuhiko Nakatani

    CHEMISTRY-A EUROPEAN JOURNAL   13 ( 16 )   4452 - 4457   2007

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  • A modular strategy for tailoring fluorescent biosensors from ribonucleopeptide complexes.

    Masaki Hagihara, Masatora Fukuda, Tetsuya Hasegawa, Takashi Morii

    Journal of the American Chemical Society   128 ( 39 )   12932 - 12940   2006.10

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  • A modular strategy for tailoring fluorescent biosensors from ribonucleopeptide complexes

    Masaki Hagihara, Masatora Fukuda, Tetsuya Hasegawa, Takashi Morii

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   128 ( 39 )   12932 - 12940   2006.10

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  • Inhibition of DNA replication by a d(CAG) repeat binding ligand.

    Hagihara M, Nakatani K

    Nucleic acids symposium series (2004)   ( 50 )   147 - 8   2006

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  • Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats.

    Kazuhiko Nakatani, Shinya Hagihara, Yuki Goto, Akio Kobori, Masaki Hagihara, Gosuke Hayashi, Motoki Kyo, Makoto Nomura, Masaki Mishima, Chojiro Kojima

    Nature chemical biology   1 ( 1 )   39 - 43   2005.6

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  • Small-molecule ligand induces nucleotide flipping in (CAG)(n) trinucleotide repeats

    K Nakatani, S Hagihara, Y Goto, A Kobori, M Hagihara, G Hayashi, M Kyo, M Nomura, M Mishima, C Kojima

    NATURE CHEMICAL BIOLOGY   1 ( 1 )   39 - 43   2005.6

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  • Stepwise molding of a highly selective ribonucleopeptide receptor.

    Shin-ichi Sato, Masatora Fukuda, Masaki Hagihara, Yukiko Tanabe, Katsutoshi Ohkubo, Takashi Morii

    Journal of the American Chemical Society   127 ( 1 )   30 - 31   2005.1

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  • Stepwise molding of a highly selective ribonucleopeptide receptor

    S Sato, M Fukuda, M Hagihara, Y Tanabe, K Ohkubo, T Morii

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   127 ( 1 )   30 - 31   2005.1

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  • Solution structure of a small-molecular ligand complexed with CAG trinucleotide repeat DNA.

    Nakatani K, Hagihara S, Goto Y, Kobori A, Hagihara M, Hayashi G, Kyo M, Nomura M, Mishima M, Kojima C

    Nucleic acids symposium series (2004)   ( 49 )   49 - 50   2005

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    PubMed

  • Solution structure of a small-molecular ligand complexed with CAG trinucleotide repeat DNA.

    Kazuhiko Nakatani, Shinya Hagihara, Yuki Goto, Akio Kobori, Masaki Hagihara, Gosuke Hayashi, Motoki Kyo, Makoto Nomura, Masaki Mishima, Chojiro Kojima

    Nucleic acids symposium series (2004)   ( 49 )   49 - 50   2005

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    PubMed

  • RNAペプチド複合体の段階的高機能化

    福田将虎, 佐藤慎一, 萩原正規, 大久保捷敏, 森井孝

    日本化学会第85春季年会,神奈川大学,2005.3.26-29   2005

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  • Application of L-DNA as a molecular tag.

    Hayashi G, Hagihara M, Nakatani K

    Nucleic acids symposium series (2004)   ( 49 )   261 - 2   2005

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    PubMed

  • Ribonucleopeptides: functional RNA-peptide complexes.

    Masaki Hagihara, Tetsuya Hasegawa, Shin-ichi Sato, Susumu Yoshikawa, Katsutoshi Ohkubo, Takashi Morii

    Biopolymers   76 ( 1 )   66 - 68   2004.6

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  • Ribonucleopeptides: Functional RNA-peptide complexes

    M Hagihara, T Hasegawa, S Sato, S Yoshikawa, K Ohkubo, T Morii

    BIOPOLYMERS   76 ( 1 )   66 - 68   2004.4

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    Web of Science

    PubMed

  • Ribonucleopeptide receptors

    Masaki Hagihara, Tetsuya Hasegawa, Shin-ichi Sato, Susumu Yoshikawa, Katsutoshi Ohkubo, Takashi Morii

    Peptide Revolution: Genomics, Proteomics & Therapeutics   556 - 558   2004

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    Web of Science

  • Optimization of an ATP-binding ribonucleopeptide receptor.

    Sato S, Hasegawa T, Hagihara M, Fukuda M, Ohkubo K, Morii T

    Nucleic acids research. Supplement (2001)   ( 3 )   239 - 40   2003

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    PubMed

  • Optimization of an ATP-binding ribonucleopeptide receptor.

    S. Sato, T. Hasegawa, M. Hagihara, M. Fukuda, K. Ohkubo, T. Morii

    Nucleic acids research. Supplement (2001)   ( 3 )   239 - 240   2003

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    PubMed

  • Design of Functional Ribonucleopeptide Complexes

    Masaki Hagihara, Shin-ichi Sato, Katsutoshi Ohkubo, Takashi Morii

    The New Frontier of RNA Science,Kyoto   2003

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  • Design of a ribonucleopeptide biosensor.

    Hagihara M, Hirata A, Ohkubo K, Morii T

    Nucleic acids research. Supplement (2001)   ( 3 )   193 - 4   2003

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  • Chemical approaches untangling sequence-specific DNA binding by proteins.

    Shin-ichi Sato, Masaki Hagihara, Kenji Sugimoto, Takashi Morii

    Chemistry (Weinheim an der Bergstrasse, Germany)   8 ( 22 )   5066 - 5071   2002.11

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  • Chemical approaches untangling sequence-specific DNA binding by proteins

    S Sato, M Hagihara, K Sugimoto, T Morii

    CHEMISTRY-A EUROPEAN JOURNAL   8 ( 22 )   5066 - 5071   2002.11

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    Web of Science

    PubMed

  • A general strategy to determine a target DNA sequence of a short peptide: application to a D-peptide.

    Takashi Morii, Tomohisa Tanaka, Shin-ichi Sato, Masaki Hagihara, Yasunori Aizawa, Keisuke Makino

    Journal of the American Chemical Society   2002.6

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  • In vitro selection of ATP-binding receptors using a ribonucleopeptide complex.

    Takashi Morii, Masaki Hagihara, Shin-ichi Sato, Keisuke Makino

    Journal of the American Chemical Society   124 ( 17 )   4617 - 4622   2002.5

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  • In vitro selection of ATP-binding receptors using a ribonucleopeptide complex

    T Morii, M Hagihara, SI Sato, K Makino

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   124 ( 17 )   4617 - 4622   2002.5

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    Web of Science

    PubMed

  • Structure-based design of a leucine zipper protein with new DNA contacting region.

    Takashi Morii, Shin-ichi Sato, Masaki Hagihara, Yasuo Mori, Keiji Imoto, Keisuke Makino

    Biochemistry   41 ( 7 )   2177 - 2183   2002.2

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  • Structure-based design of a leucine zipper protein with new DNA contacting region

    Takashi Morii, Shin-Ichi Sato, Masaki Hagihara, Yasuo Mori, Keiji Imoto, Keisuke Makino

    Biochemistry   41 ( 7 )   2177 - 2183   2002.2

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    Scopus

    PubMed

  • A general strategy to determine a target DNA sequence of a short peptide: Application to a D-peptide

    T Morii, T Tanaka, S Sato, M Hagihara, Y Aizawa, K Makino

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   124 ( 2 )   180 - 181   2002.1

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    Web of Science

    PubMed

  • オリゴペプチド標的DNA配列の一般的決定法

    佐藤慎一, 田中智久, 萩原正規, 相沢康則, 森井孝, 牧野圭祐

    日本化学会第81春季年会,2F6-10,2002   2002

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  • RNA・ペプチド複合体(リボヌクレオペプチド)による分子認識

    萩原正規, 森井孝, 牧野圭祐

    日本化学会第81春季年会,2F6-12,2002   2002

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  • A new strategy to determine the target DNA sequence of a short peptide.

    Sato S, Honjyo H, Tsuji S, Hagihara M, Makino K, Morii T

    Nucleic acids research. Supplement (2001)   ( 2 )   205 - 6   2002

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    PubMed

  • Recognition of small molecules by a ribonucleopeptide.

    M. Hagihara, T. Morii, K. Makino

    Nucleic Acids Res Suppl   ( 1 )   7 - 8   2001

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    PubMed

  • In vitro selection of RNA aptamers that respond to a small RNA-binding ligand

    M. hagihara, T. Morii, K. Makino

    環太平洋国際化学会議,Hawaii(米国)   2000

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  • Participation of oligomerization through C-terminal D domain region of Sp1 in DNA binding

    K Matsushita, M Hagihara, Y Sugiura

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   21 ( 10 )   1094 - 1097   1998.10

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    Web of Science

  • Participation of oligomerization through C-terminal D domain region of Sp1 in DNA binding.

    Keizo Matsushita, Masaki Hagihara, Yukio Sugiura

    Biological & Pharmaceutical Bulletin   1998.6

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  • A novel zinc finger-based DNA cutter: biosynthetic design and highly selective DNA cleavage.

    Makoto Nagaoka, Masaki Hagihara, Jun Kuwahara, Yukio Sugiura

    Journal of the American Chemical Society   1994.6

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  • A NOVEL ZINC FINGER-BASED DNA CUTTER - BIOSYNTHETIC DESIGN AND HIGHLY SELECTIVE DNA CLEAVAGE

    M NAGAOKA, M HAGIHARA, J KUWAHARA, Y SUGIURA

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   116 ( 9 )   4085 - 4086   1994.5

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    Web of Science

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Books

  • Methods in Molecular Biology, Vol. 1111, P. 197-208

    Masaki Hagihara( Role: Contributor ,  Guanine-Tethered Antisense Oligonucleotides as Synthetic Riboregulators)

    Springer  2014 

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    Language:English Book type:Scholarly book

  • Chembiomolecular Science, At the Frontier of Chemistry and Biology, P. 59-67

    Shiori Umemoto, Changfeng Hong, Jinhua Zhang, Takeo Fukuzumi, Asako Murata, Masaki Hagihara, Kazuhiko Nakatani( Role: Contributor ,  Toward the Discovery of Small Molecules Affecting RNA Function)

    Springer  2011 

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    Language:English Book type:Scholarly book

  • Peptide Revolution: Genomics, Proteomics & Therapeutics. P. 556–558

    Masaki Hagihara, Tetsuya Hasegawa, Shin-ichi Sato, Susumu Yoshikawa, Katsutoshi Ohkubo, Takashi Morii( Role: Contributor)

    American Peptide Society  2004 

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    Language:English Book type:Scholarly book

Review Papers

  • Guanine-Tethered Antisense Oligonucleotides as Synthetic Riboregulators

    Masaki Hagihara

    Methods in Molecular Biology   2014.4

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher:Springer   Kind of work:Single Work  

  • Toward the Discovery of Small Molecules Affecting RNA Function

    Shiori Umemoto, Changfeng Hong, Jinhua Zhang, Takeo Fukuzumi, Asako Murata, Masaki Hagihara, Kazuhiko Nakatani

    Chembiomolecular Science, At the Frontier of Chemistry and Biology   2012.6

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  • Development of a Nanobiodevice based Ribonucleopeptide Complex

    T. Hasegawa, M. Hagihara, S. Sato, K. Ohkubo, T. Morii, S. Yoshikawa

    The 2nd International Symposium on Sustainable Energy System,Kyoto University Clock Tower Centennial Hall, Kyoto (Japan),2004.12.17-18   2004.12

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  • Tailoring receptors and sensors from an RNA-peptide assmebly

    Y. Tanabe, M. Hagihara, S. Sato, K. Ohkubo, T. Morii

    International symposium on Nano-organization and Function,Tokyo,2004.11.11-12   2004.11

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  • Design of sensing ribonucleopeptides for small ligands.

    M. Hagihara, T. Hasegawa, Y. Tanabe, S. Sato, S. Yoshikawa, K. Ohkubo, T. Morii

    Nucleic acids symposium series (2004)   ( 48 )   33 - 34   2004

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    PubMed

    J-GLOBAL

  • Recognition of Small Molecules by an RNA-peptide Complex

    HAGIHARA Masaki, SATO Shin-ichi, MORII Takashi, MAKINO Keisuke

    2002   425 - 426   2003.2

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    CiNii Books

  • Design of a ribonucleopeptide biosensor

    Masaki Hagihara, Akiyoshi Hirata, Katsutoshi Ohkubo, Takashi Morii

    the 30th Nucleic Acids Chemistry Symposium,Sapporo   2003

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  • Design of phosphotyrosine-specific ribonucleopeptide receptors

    Tetsuya Hasegawa, Masaki Hagihara, Shin-ichi Sato, Takashi Morii, Katsutoshi Ohkubo, Susumu Yoshikawa

    The 1st International Symposium on Sustainable Energy System,Kyoto University 21COE Establishment of COE on Sustainable Energy System,Kyoto   2003

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  • 短鎖ペプチドによる認識DNA塩基配列の決定

    佐藤慎一, 本庄弘一, 辻晋司, 萩原正規, 牧野圭祐, 森井孝

    第29回核酸化学シンポジウム,2-P37,2002   2002

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  • RNA・ペプチド複合体による人工リセプター(リボヌクレオペプチドリセプター)の創製

    萩原正規, 森井孝, 牧野圭祐

    第74回日本生化学会大会,4P-012,2001   2001

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Awards

  • Young Investigators’ Awards

    2007.04

Social Activities

  • 青森県立弘前南高等学校「南陵サイエンスセミナー」

    2017.11.11

  • 弘前南高校SSH事業「南陵サイエンスセミナー」

    2017.11

  • 化学への招待 弘前大学一日体験化学教室

    2017.08.07

  • 青森県立弘前南高等学校「南陵サイエンスセミナー」

    2016.11.12

  • 弘前南高校SSH事業「南陵サイエンスセミナー」

    2016.11

  • 青森県立弘前南高等学校「南陵サイエンスセミナーIII」

    2015.10.31

  • 青森県立弘前南高等学校「南陵サイエンスセミナーIⅡ」

    2015.10

  • 北海道札幌新川高等学校 上級学校セミナー2014

    2014.11.05

  • 北海道札幌新川高等学校 上級学校セミナー2014

    2014.11

  • 青森県立弘前南高等学校「南陵サイエンスセミナーII」

    2014.10.04

  • 青森県立弘前南高等学校「南陵サイエンスセミナーⅡ」

    2014.10

  • 青森県立八戸北高等学校「青森サイエンスキャンプ」

    2014.09.06 - 2014.09.07

  • 青森県立八戸北高等学校「青森サイエンスキャンプ」

    2014.09

  • 平成26年度教員免許状更新講習会担当

    2014.08

  • 平成26年度弘前大学ドリーム講座

    2014.07.25

  • 平成26年度弘前大学ドリーム講座 三沢高等学校

    2014.07

  • 青森県立弘前南高等学校「南陵サイエンスセミナーII」

    2013.10.05 - 2013.10.06

  • 青森県立弘前南高等学校「南陵サイエンスセミナーⅡ」

    2013.10

  • 青森県立八戸北高等学校「青森サイエンスキャンプ」

    2013.09.07 - 2013.09.08

  • 青森県立八戸北高等学校「青森サイエンスキャンプ」

    2013.09

  • 青森県立八戸北高等学校「青森サイエンスキャンプ」

    2012.09.08 - 2012.09.09

  • 青森県立八戸北高等学校「青森サイエンスキャンプ」

    2012.09

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