Updated on 2021/12/08

写真a

 
HAGIHARA Masaki
 
Affiliation
Division of Natural Sciences Materials Science and Technology Section
Full-time staff
Graduate School of Science and Technology Research Division

Degree

  • 博士(エネルギー科学)

Research Areas

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules

Professional Memberships

  • 日本薬学会

  • 日本ケミカルバイオロジー学会

  • 日本化学会

Papers

  • Small molecule-induced trinucleotide repeat contractions during in vitro DNA synthesis

    Chikara Dohno, Masaki Hagihara, Nursakinah Binti Mohd Zaifuddin, Mizuki Nihei, Kaoru Saito, Kazuhiko Nakatani

    Chemical communications (Cambridge, England)   2021.3

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  • Structures and Catalytic Activities of Complexes between Heme and All Parallel-Stranded Monomeric G-Quadruplex DNAs

    Yasuhiko Yamamoto, Haruka Araki, Ryosuke Shinomiya, Kosuke Hayasaka, Yusaku Nakayama, Kentaro Ochi, Tomokazu Shibata, Atsuya Momotake, Takako Ohyama, Masaki Hagihara, and Hikaru Hemmi

    Biochemistry   2018.9

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  • A Small Molecule That Represses Translation of G‐Quadruplex-Containing mRNA

    Yousuke Katsuda, Shin-ichi Sato, Lisa Asano, Yoshitaka Morimura, Tomoyuki Furuta, Hiroshi Sugiyama, Masaki Hagihara, Motonari Uesugi

    Journal of the American Chemical Society   2016.7

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  • G-quadruplex DNA- and RNA-Specific-Binding Proteins Engineered from the RGG Domain of TLS/FUS

    Kentaro Takahama, Arisa Miyawaki, Takumi Shitara, Keita Mitsuya, Masayuki Morikawa, Masaki Hagihara, Katsuhito Kino, Ayumu Yamamoto and Takanori Oyoshi

    ACS Chemical Biology   2015.11

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  • Recognition of Chelerythrine to Human Telomeric DNA and RNA G-quadruplexes

    Li-Ping Bai, Masaki Hagihara, Kazuhiko Nakatani, Zhi-Hong Jiang

    Scientific Reports   2014.10

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  • Formation of Ligand-Assisted Complex of Two RNA Hairpin Loops

    Changfeng Hong, Takahiro Otabe, Saki Matsumoto, Chikara Dohno, Asako Murata, Masaki Hagihara, and Kazuhiko Nakatani

    Chemistry European Journal   2014.3

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  • A Synthetic Riboswitch that Operates using a Rationally Designed Ligand-RNA Pair.

    Chikara Dohno, Izumi Kohyama, Maki Kimura, Masaki Hagihara, Kazuhiko Nakatani

    Angewandte Chemie (International ed. in English)   52 ( 38 )   9976 - 9979   2013.9

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  • Activation of prokaryotic translation by antisense oligonucleotides binding to coding region of mRNA.

    Gosuke Hayashi, Changfeng Hong, Masaki Hagihara, Kazuhiko Nakatani

    Biochemical and biophysical research communications   429 ( 1-2 )   105 - 110   2012.12

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  • Assembly of a Small DNA Rectangular Parallelepiped Block into Higher Order Nanostructures.

    Hiroki Nakagawa, Mariko Toda, Hiroshi Atsumi, Masaki Hagihara, Mitsuko Hayashi-Nishino, Chikara Dohno, Kazuhiko Nakatani

    Chemistry Letters   2012.11

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  • Structure-activity studies on the fluorescent indicator in a displacement assay for the screening of small molecules binding to RNA.

    Shiori Umemoto, Seongwang Im, Jinhua Zhang, Masaki Hagihara, Asako Murata, Yasue Harada, Takeo Fukuzumi, Takahiro Wazaki, Shin-ichi Sasaoka, Kazuhiko Nakatani

    Chemistry (Weinheim an der Bergstrasse, Germany)   18 ( 32 )   9999 - 10008   2012.8

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  • A small molecule regulates hairpin structures in d(CGG) trinucleotide repeats.

    Masaki Hagihara, Hanping He, Maki Kimura, Kazuhiko Nakatani

    Bioorganic & medicinal chemistry letters   22 ( 5 )   2000 - 2003   2012.3

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  • Small molecule modulates hairpin structures in CAG trinucleotide repeats.

    Masaki Hagihara, Hanping He, Kazuhiko Nakatani

    Chembiochem : a European journal of chemical biology   12 ( 11 )   1686 - 1689   2011.7

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  • Ligand-assisted complex formation of two DNA hairpin loops.

    Changfeng Hong, Masaki Hagihara, Kazuhiko Nakatani

    Angewandte Chemie (International ed. in English)   50 ( 19 )   4390 - 4393   2011.5

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  • Antisense-induced guanine quadruplexes inhibit reverse transcription by HIV-1 reverse transcriptase.

    Masaki Hagihara, Lisa Yamauchi, Akiko Seo, Keisuke Yoneda, Mayo Senda, Kazuhiko Nakatani

    Journal of the American Chemical Society   132 ( 32 )   11171 - 11178   2010.8

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  • A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA.

    Masaki Hagihara, Keisuke Yoneda, Hiroaki Yabuuchi, Yasushi Okuno, Kazuhiko Nakatani

    Bioorganic & medicinal chemistry letters   20 ( 7 )   2350 - 2353   2010.4

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  • A small molecule affecting the replication of trinucleotide repeat d(GAA)n.

    Hanping He, Masaki Hagihara, Kazuhiko Nakatani

    Chemistry (Weinheim an der Bergstrasse, Germany)   15 ( 40 )   10641 - 10648   2009.10

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  • RNA aptamers that reversibly bind photoresponsive azobenzene-containing peptides.

    Gosuke Hayashi, Masaki Hagihara, Kazuhiko Nakatani

    Chemistry (Weinheim an der Bergstrasse, Germany)   15 ( 2 )   424 - 432   2009.6

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  • Secondary-structure-inducible ligand fluorescence coupled with PCR.

    Fumie Takei, Masako Igarashi, Masaki Hagihara, Yoshimi Oka, Yoshihiro Soya, Kazuhiko Nakatani

    Angewandte Chemie (International ed. in English)   48 ( 42 )   7822 - 7824   2009.6

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  • Unstable tandem repeats in promoters confer transcriptional evolvability.

    Marcelo D Vinces, Matthieu Legendre, Marina Caldara, Masaki Hagihara, Kevin J Verstrepen

    Science (New York, N.Y.)   324 ( 5931 )   1213 - 1216   2009.5

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  • Ligand binding to tandem G quadruplexes from human telomeric DNA.

    Li-Ping Bai, Masaki Hagihara, Zhi-Hong Jiang, Kazuhiko Nakatani

    Chembiochem : a European journal of chemical biology   9 ( 16 )   2583 - 2587   2008.11

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  • DNA labeling by ligand inducible secondary structure.

    Tao Peng, Hanping He, Masaki Hagihara, Kazuhiko Nakatani

    Chembiochem : a European journal of chemical biology   9 ( 12 )   1893 - 1897   2008.8

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  • Context-dependent fluorescence detection of a phosphorylated tyrosine residue by a ribonucleopeptide.

    Tetsuya Hasegawa, Masaki Hagihara, Masatora Fukuda, Shun Nakano, Nobutaka Fujieda, Takashi Morii

    Journal of the American Chemical Society   130 ( 27 )   8804 - 8812   2008.7

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  • Genotyping by allele-specific L-DNA-tagged PCR.

    Gosuke Hayashi, Masaki Hagihara, Kazuhiko Nakatani

    Journal of biotechnology   135 ( 2 )   157 - 160   2008.6

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  • Ligand-stabilized hairpin structures interfere with elongation of human telomere.

    Masaki Hagihara, Yuki Goto, Kazuhiko Nakatani

    Chembiochem : a European journal of chemical biology   9 ( 4 )   510 - 513   2008.3

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  • Photoregulation of a peptide-RNA interaction on a gold surface.

    Gosuke Hayashi, Masaki Hagihara, Chikara Dohno, Kazuhiko Nakatani

    Journal of the American Chemical Society   129 ( 28 )   8678 - 8679   2007.7

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  • Allele specific C-bulge probes with one unique fluorescent molecule discriminate the single nucleotide polymorphism in DNA.

    Fumie Takei, Hitoshi Suda, Masaki Hagihara, Jinhua Zhang, Akio Kobori, Kazuhiko Nakatani

    Chemistry (Weinheim an der Bergstrasse, Germany)   13 ( 16 )   4452 - 4457   2007.6

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  • Stepwise functionalization of ribonucleopeptides: optimization of the response of fluorescent ribonucleopeptide sensors for ATP.

    Tetsuya Hasegawa, Masaki Hagihara, Masatora Fukuda, Takashi Morii

    Nucleosides, nucleotides & nucleic acids   26 ( 10-12 )   1277 - 1281   2007.6

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  • Small-molecule binding to the nonquadruplex form of the human telomeric sequence.

    Yuki Goto, Shinya Hagihara, Masaki Hagihara, Kazuhiko Nakatani

    Chembiochem : a European journal of chemical biology   8 ( 7 )   723 - 726   2007.5

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  • Detection of L-DNA-tagged PCR products by surface plasmon resonance imaging.

    Gosuke Hayashi, Masaki Hagihara, Akio Kobori, Kazuhiko Nakatani

    Chembiochem : a European journal of chemical biology   8 ( 2 )   169 - 171   2007.1

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  • A modular strategy for tailoring fluorescent biosensors from ribonucleopeptide complexes.

    Masaki Hagihara, Masatora Fukuda, Tetsuya Hasegawa, Takashi Morii

    Journal of the American Chemical Society   128 ( 39 )   12932 - 12940   2006.10

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  • Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats.

    Kazuhiko Nakatani, Shinya Hagihara, Yuki Goto, Akio Kobori, Masaki Hagihara, Gosuke Hayashi, Motoki Kyo, Makoto Nomura, Masaki Mishima, Chojiro Kojima

    Nature chemical biology   1 ( 1 )   39 - 43   2005.6

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  • Stepwise molding of a highly selective ribonucleopeptide receptor.

    Shin-ichi Sato, Masatora Fukuda, Masaki Hagihara, Yukiko Tanabe, Katsutoshi Ohkubo, Takashi Morii

    Journal of the American Chemical Society   127 ( 1 )   30 - 31   2005.1

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  • Ribonucleopeptides: functional RNA-peptide complexes.

    Masaki Hagihara, Tetsuya Hasegawa, Shin-ichi Sato, Susumu Yoshikawa, Katsutoshi Ohkubo, Takashi Morii

    Biopolymers   76 ( 1 )   66 - 68   2004.6

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  • Chemical approaches untangling sequence-specific DNA binding by proteins.

    Shin-ichi Sato, Masaki Hagihara, Kenji Sugimoto, Takashi Morii

    Chemistry (Weinheim an der Bergstrasse, Germany)   8 ( 22 )   5066 - 5071   2002.11

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  • A general strategy to determine a target DNA sequence of a short peptide: application to a D-peptide.

    Takashi Morii, Tomohisa Tanaka, Shin-ichi Sato, Masaki Hagihara, Yasunori Aizawa, Keisuke Makino

    Journal of the American Chemical Society   2002.6

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  • In vitro selection of ATP-binding receptors using a ribonucleopeptide complex.

    Takashi Morii, Masaki Hagihara, Shin-ichi Sato, Keisuke Makino

    Journal of the American Chemical Society   124 ( 17 )   4617 - 4622   2002.5

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  • Structure-based design of a leucine zipper protein with new DNA contacting region.

    Takashi Morii, Shin-ichi Sato, Masaki Hagihara, Yasuo Mori, Keiji Imoto, Keisuke Makino

    Biochemistry   41 ( 7 )   2177 - 2183   2002.2

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  • Participation of oligomerization through C-terminal D domain region of Sp1 in DNA binding.

    Keizo Matsushita, Masaki Hagihara, Yukio Sugiura

    Biological & Pharmaceutical Bulletin   1998.6

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  • A novel zinc finger-based DNA cutter: biosynthetic design and highly selective DNA cleavage.

    Makoto Nagaoka, Masaki Hagihara, Jun Kuwahara, Yukio Sugiura

    Journal of the American Chemical Society   1994.6

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Review Papers

  • Guanine-Tethered Antisense Oligonucleotides as Synthetic Riboregulators

    Masaki Hagihara

    Methods in Molecular Biology   2014.4

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher:Springer   Kind of work:Single Work  

  • Toward the Discovery of Small Molecules Affecting RNA Function

    Shiori Umemoto, Changfeng Hong, Jinhua Zhang, Takeo Fukuzumi, Asako Murata, Masaki Hagihara, Kazuhiko Nakatani

    Chembiomolecular Science, At the Frontier of Chemistry and Biology   2012.6

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Awards

  • Young Investigators’ Awards

    2007.04

Social Activities

  • 弘前南高校SSH事業「南陵サイエンスセミナー」

    2017.11

  • 弘前南高校SSH事業「南陵サイエンスセミナー」

    2016.11

  • 青森県立弘前南高等学校「南陵サイエンスセミナーIⅡ」

    2015.10

  • 北海道札幌新川高等学校 上級学校セミナー2014

    2014.11

  • 青森県立弘前南高等学校「南陵サイエンスセミナーⅡ」

    2014.10

  • 青森県立八戸北高等学校「青森サイエンスキャンプ」

    2014.09

  • 平成26年度弘前大学ドリーム講座 三沢高等学校

    2014.07

  • 青森県立弘前南高等学校「南陵サイエンスセミナーⅡ」

    2013.10

  • 青森県立八戸北高等学校「青森サイエンスキャンプ」

    2013.09

  • 青森県立八戸北高等学校「青森サイエンスキャンプ」

    2012.09

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