論文 - 萩原 正規
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ExpandedGeneTargetinginRNAHackingWith G-Tract-SupplyStapleOligomers
Tomoki Kida, Yua Hasegawa, Miko Kato, Mahiro Ohtani, Ayu Matsumoto, Ririka Taniguchi, Rinka Ohno, Hiroshi Sugiyama, Toshihiro Ihara, Masaki Hagihara, Shin-ichi Sato, Yousuke Katsuda
Angewandte Chemie International Edition 2026年
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Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics
Yousuke Katsuda, Takuto Kamura, Tomoki Kida, Rinka Ohno, Shuhei Shiroto, Yua Hasegawa, Kaito Utsumi, Yuki Sakamoto, Shinichiro Nakamura, Taishi Nakamura, Kenichi Tsujita, Yusuke Kitamura, Yukiko Kamiya, Hiroyuki Asanuma, Toshihiro Ihara, Masaki Hagihara & Shin-ichi Sato
nature biomedical engineering 2025年10月
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Small molecule-based detection of non-canonical RNA G-quadruplex structures that modulate protein translation
Yousuke Katsuda, Shin-ichi Sato, Maimi Inoue, Hisashi Tsugawa, Takuto Kamura, Tomoki Kida, Rio Matsumoto Sefan Asamitsu, Norifumi Shioda, Shuhei Shiroto, Yoshiki Oosawatsu, Kenji Yatsuzuka, Yusuke Kitamura, Masaki Hagihara, Toshihiro Ihara and Motonari Uesugi
Nucleic Acids Research 50 ( 14 ) 8143 - 8153 2022年07月
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Development of triggerable peroxidase-tagged primers for colorimetric DNA detection applicable to various DNA polymerases
Hironao Munakata, Yuri Sohma, Kaito Utsumi, Rinka Ohno, Kotaro Ishida, Eiji Morita, Shin-ichi Sato, Masaki Hagihara
Chemistry Letters 53 ( 11 ) 2024年11月
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Triggerable peroxidase-tagged primer enables naked eye monitoring of PCR amplification
Hironao Munakata, Yuri Sohma, Kotaro Ishida, Eiji Morita, Shin-ichi Sato, Masaki Hagihara
Chemistry Letters 53 ( 10 ) 2024年10月
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Short Tandem Repeat Contractions during In Vitro DNA Synthesis by Repeat-binding Molecules
Hagihara Masaki, Dohno Chikara, Saito Kaoru, Sugimoto Kazuhiro, Hishinuma Yuta, Sohma Yuri, Shibata Tomonori, Nakatani Kazuhiko
Chemistry Letters 50 ( 11 ) 1848 - 1851 2021年11月
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Guanine-tethered Oligonucleotides Restore Abnormal Protein Synthesis with a SNP Mutation in a 5′-UTR G-quadruplex of Human MSH2
Hagihara Masaki, Shiroto Shuhei, Igarashi Shunya, Sato Shin-ichi
Chemistry Letters 50 ( 10 ) 1806 - 1809 2021年10月
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Inhibition of protein synthesis through RNA-based tandem G-quadruplex formation.
Hagihara M
Chemical communications (Cambridge, England) 57 ( 65 ) 8063 - 8066 2021年08月
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Small molecule-induced trinucleotide repeat contractions during in vitro DNA synthesis
Chikara Dohno, Masaki Hagihara, Nursakinah Binti Mohd Zaifuddin, Mizuki Nihei, Kaoru Saito, Kazuhiko Nakatani
Chemical communications (Cambridge, England) 57 ( 26 ) 3235 - 3238 2021年03月
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Structures and Catalytic Activities of Complexes between Heme and All Parallel-Stranded Monomeric G-Quadruplex DNAs
Yasuhiko Yamamoto, Haruka Araki, Ryosuke Shinomiya, Kosuke Hayasaka, Yusaku Nakayama, Kentaro Ochi, Tomokazu Shibata, Atsuya Momotake, Takako Ohyama, Masaki Hagihara, and Hikaru Hemmi
Biochemistry 57 ( 41 ) 5938 - 5948 2018年09月
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Structures and Catalytic Activities of Complexes between Heme and All Parallel-Stranded Monomeric G‐Quadruplex DNAs
Yasuhiko Yamamoto, Haruka Araki, Ryosuke Shinomiya, Kosuke Hayasaka, Yusaku Nakayama, Kentaro Ochi, Tomokazu Shibata, Atsuya Momotake, Takako Ohyama, Masaki Hagihara, Hikaru Hemmi
Biochemistry, in press 2018年
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A Small Molecule That Represses Translation of G‐Quadruplex-Containing mRNA
Yousuke Katsuda, Shin-ichi Sato, Lisa Asano, Yoshitaka Morimura, Tomoyuki Furuta, Hiroshi Sugiyama, Masaki Hagihara, Motonari Uesugi
Journal of the American Chemical Society 138 ( 29 ) 9037 - 9040 2016年07月
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G-quadruplex DNA- and RNA-Specific-Binding Proteins Engineered from the RGG Domain of TLS/FUS
Kentaro Takahama, Arisa Miyawaki, Takumi Shitara, Keita Mitsuya, Masayuki Morikawa, Masaki Hagihara, Katsuhito Kino, Ayumu Yamamoto and Takanori Oyoshi
ACS Chemical Biology 10 ( 11 ) 2564 - 2569 2015年11月
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Recognition of Chelerythrine to Human Telomeric DNA and RNA G-quadruplexes
Li-Ping Bai, Masaki Hagihara, Kazuhiko Nakatani, Zhi-Hong Jiang
Scientific Reports 2014年10月
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Recognition of chelerythrine to human telomeric DNA and RNA G-quadruplexes.
Bai LP, Hagihara M, Nakatani K, Jiang ZH
Scientific reports 4 6767 2014年10月
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Formation of a ligand-assisted complex of two RNA hairpin loops.
Hong C, Otabe T, Matsumoto S, Dohno C, Murata A, Hagihara M, Nakatani K
Chemistry (Weinheim an der Bergstrasse, Germany) 20 ( 18 ) 5282 - 5287 2014年04月
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Formation of Ligand-Assisted Complex of Two RNA Hairpin Loops
Changfeng Hong, Takahiro Otabe, Saki Matsumoto, Chikara Dohno, Asako Murata, Masaki Hagihara, and Kazuhiko Nakatani
Chemistry European Journal 2014年03月
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Guanine-tethered antisense oligonucleotides as synthetic riboregulators.
Hagihara M
Methods in molecular biology (Clifton, N.J.) 1111 197 - 207 2014年
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A Synthetic Riboswitch that Operates using a Rationally Designed Ligand-RNA Pair.
Chikara Dohno, Izumi Kohyama, Maki Kimura, Masaki Hagihara, Kazuhiko Nakatani
Angewandte Chemie (International ed. in English) 52 ( 38 ) 9976 - 9979 2013年09月
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A synthetic riboswitch that operates using a rationally designed ligand-RNA pair.
Dohno C, Kohyama I, Kimura M, Hagihara M, Nakatani K
Angewandte Chemie (International ed. in English) 52 ( 38 ) 9976 - 9979 2013年09月