論文 - 花田 賢二
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Incidence and Predictor for Symptomatic Stroke within 30 days after Transcatheter Aortic Valve Implantation: Insights From the LAPLACE-TAVI Registry.
Yokoyama H, Yamazaki K, Shikanai S, Hamadate M, Tsushima M, Narita N, Senoo M, Ichikawa H, Shibutani S, Hanada K, Saito Y, Murata K, Imamura Y, Higuchi R, Hagiya K, Takamisawa I, Nanasato M, Iguchi N, Takayama M, Shimizu J, Tamura H, Doi S, Okazaki S, Ishiyama M, Fukutomi M, Takanashi S, Saji M, Minakawa M, Tomita H
Journal of cardiology 2026年02月
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Impact of Preoperative Diuretics Treatment on Long-Term Clinical Outcomes After Transcatheter Aortic Valve Implantation.
Hirosawa S, Yokoyama H, Yamazaki K, Shikanai S, Tsushima M, Narita N, Senoo M, Ichikawa H, Shibutani S, Hanada K, Saito Y, Murata K, Imamura Y, Higuchi R, Hagiya K, Takamisawa I, Nanasato M, Iguchi N, Takayama M, Shimizu J, Tamura H, Doi S, Okazaki S, Ishiyama M, Fukutomi M, Takanashi S, Saji M, Minakawa M, Tomita H
International heart journal 67 ( 1 ) 27 - 34 2026年01月
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Impact of preprocedural atrial fibrillation and body mass index on clinical outcomes after transcatheter aortic valve implantation
Umezaki, H; Yokoyama, H; Hirosawa, S; Yamazaki, K; Shikanai, S; Hamadate, M; Tsushima, M; Senoo, M; Narita, N; Ichikawa, H; Shibutani, S; Hanada, K; Murata, K; Imamura, Y; Saito, Y; Minakawa, M; Tomita, H
HEART AND VESSELS 2025年12月
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Incidence and Predictors of Appropriate Implantable Cardioverter Defibrillator Therapy in Japanese Ischemic Heart Disease Patients.
Hanada K, Sasaki S, Kinjo T, Shikanai S, Yamazaki K, Kato T, Tsushima M, Senoo M, Narita N, Ichikawa H, Shibutani S, Yokoyama H, Yokota T, Okumura K, Tomita H
Circulation journal : official journal of the Japanese Circulation Society 89 ( 3 ) 354 - 363 2025年02月
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Impact of Triglyceride Levels on the Long-term Clinical Outcomes in Patients With Acute Myocardial Infarction
Kato, K; Yokoyama, H; Iwasaki, T; Konno, Y; Yamazaki, K; Shikanai, S; Kato, T; Tsushima, M; Senoo, M; Narita, N; Ichikawa, H; Shibutani, S; Hanada, K; Tomita, H
IN VIVO 38 ( 6 ) 3078 - 3084 2024年11月
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Inhibition of Src ameliorates the progression of pulmonary arterial hypertension in experimental mouse model
Miura Naotake, Hanada Kenji, Hirosawa Shun, Umezaki Hitoshi, Konno Yuki, Kato Kazufumi, Iwasaki Toshihiro, Tomita Hirofumi
Hirosaki Medical Journal 75 ( 1 ) 31 - 38 2024年10月
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Association between lipoprotein-associated phospholipase A2 gene Val279Phe homozygous genotypes and variant angina in Japanese women
Iwasaki, T; Shibutani, S; Soma, T; Saito, K; Washima, S; Kato, K; Konno, Y; Umezaki, H; Hirosawa, S; Hanada, K; Yokoyama, H; Tomita, H
EUROPEAN HEART JOURNAL 45 2024年10月
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Carvedilol suppresses coronary artery spasm in A-kinase anchoring protein 150 knockout mouse
Konno, Y; Hanada, K; Umezaki, H; Hirosawa, S; Iwasaki, I; Kato, K; Soma, T; Washima, S; Saito, K; Shibutani, S; Tomita, H
EUROPEAN HEART JOURNAL 45 2024年10月
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Is multidisciplinary treatment effective for invasive intraductal papillary mucinous carcinoma?
Hirono, S; Higuchi, R; Honda, G; Nara, S; Esaki, M; Gotohda, N; Takami, H; Unno, M; Sugiura, T; Ohtsuka, M; Shimizu, Y; Matsumoto, I; Kin, T; Isayama, H; Hashimoto, D; Seyama, Y; Nagano, H; Hakamada, K; Hirano, S; Nagakawa, Y; Mizuno, S; Takahashi, H; Shibuya, K; Sasanuma, H; Aoki, T; Kohara, Y; Rikiyama, T; Nakamura, M; Endo, I; Sakamoto, Y; Horiguchi, A; Hatori, T; Akita, H; Ueki, T; Idichi, T; Hanada, K; Suzuki, S; Okano, K; Maehira, H; Motoi, F; Fujino, Y; Tanno, S; Yanagisawa, A; Takeyama, Y; Okazaki, K; Satoi, S; Yamaue, H
ANNALS OF GASTROENTEROLOGICAL SURGERY 8 ( 5 ) 845 - 859 2024年09月
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Comparison of procedural and clinical outcomes between optical coherence tomography and intravascular ultrasound guided percutaneous coronary intervention for patients with acute coronary syndrome
Shikanai Shun, Yokota Takashi, Yokoyama Hiroaki, Soma Takanobu, Sakai Shuntaro, Sorimachi Yuya, Hamaura Shogo, Yamazaki Ken, Tsushima Michiko, Senoo Maiko, Ichikawa Hiroaki, Nishizaki Fumie, Shibutani Shuji, Hanada Kenji, Tomita Hirofumi
Hirosaki Medical Journal 74 ( 1-4 ) 6 - 16 2024年03月
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Serial longitudinal changes of coronary calcified plaques with clear outer borders under intensive lipid management: insights from optical coherence tomography
Soma Takanobu, Yokoyama Hiroaki, Saito Kazumasa, Washima Shota, Tsushima Michiko, Senoo Maiko, Ichikawa Hiroaki, Nishizaki Fumie, Shibutani Shuji, Hanada Kenji, Tomita Hirofumi
HEART AND VESSELS 39 ( 5 ) 373 - 381 2023年12月
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Prognostic Impact of Acute Myocardial Infarction-Related Ventricular Tachyarrhythmia in the Current Era - Reply.
Hanada K, Tomita H
Circulation journal : official journal of the Japanese Circulation Society advpub ( 0 ) 262 2023年12月
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Induced pluripotent stem cell-derived vascular smooth muscle cells as an in vitro model of coronary spastic angina
Soma T., Shibutani S., Iwasaki T., Saito K., Washima S., Kato K., Konno Y., Hanada K., Yokoyama H., Tomita H.
EUROPEAN HEART JOURNAL 44 2023年11月
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Incidence, Predictors, and Outcome Associated With Ventricular Tachycardia or Fibrillation in Patients Undergoing Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction.
Hanada K, Kinjo T, Yokoyama H, Tsushima M, Senoo M, Ichikawa H, Nishizaki F, Shibutani S, Yokota T, Okumura K, Tomita H
Circulation journal : official journal of the Japanese Circulation Society advpub ( 0 ) 1254 - 1264 2023年09月
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Reduced Left Ventricular Ejection Fraction Is a Risk for Sudden Cardiac Death in the Early Period After Hospital Discharge in Patients With Acute Myocardial Infarction.
Hanada K, Sasaki S, Seno M, Kimura Y, Ichikawa H, Nishizaki F, Yokoyama H, Yokota T, Okumura K, Tomita H
日本循環器病學 advpub ( 0 ) 1490 - 1498 2022年03月
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経カテーテル的大動脈弁留置術中の経食道心エコーにて乳頭状線維弾性腫が疑われた2症例
酒井 峻太郎, 横山 公章, 市川 博章, 木村 嘉宏, 西崎 史恵, 花田 賢二, 横田 貴志, 山田 雅大, 富田 泰史
心臓 54 ( 1 ) 100 - 105 2022年01月
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Rivaroxaban attenuates cardiac hypertrophy by inhibiting protease-activated receptor-2 signaling in renin-overexpressing hypertensive mice
Narita Masato, Hanada Kenji, Kawamura Yosuke, Ichikawa Hiroaki, Sakai Shuntaro, Yokono Yoshikazu, Senoo Maiko, Narita Noritomo, Shimada Michiko, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi
HYPERTENSION RESEARCH 44 ( 10 ) 1261 - 1273 2021年10月
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Diltiazem Inhibits Coronary Spasm via Inhibition of Cav1.2 Phosphorylation and Protein Kinase C Activation in a Mouse Model of Coronary Spastic Angina
Ishida Yuji, Kitayama Kazutaka, Hanada Kenji, Shibutani Shuji, Nishizaki Kimitaka, Kinjo Takahiko, Endo Tomohide, Suzuki Akiko, Tateyama Shunta, Nishizaki Fumie, Sukekawa Takanori, Tanaka Makoto, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi
Japanese Heart Journal 62 ( 4 ) 910 - 918 2021年07月
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内科的治療で心嚢液の減少を認めた原発性乳糜心膜症の1例
酒井 峻太郎, 西崎 史恵, 芦立 俊宗, 遠藤 知秀, 澁谷 修司, 花田 賢二, 横山 公章, 横田 貴志, 山田 雅大, 掛端 伸也, 福田 幾夫, 富田 泰史
心臓 53 ( 7 ) 737 - 742 2021年07月
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Clinical impact of complete atrioventricular block in patients with ST-segment elevation myocardial infarction
Kawamura Yosuke, Yokoyama Hiroaki, Kitayama Kazutaka, Miura Naotake, Hamadate Misato, Nagawa Daiki, Nozaka Masashi, Nakata Masamichi, Nishizaki Fumie, Hanada Kenji, Yokota Takashi, Yamada Masahiro, Higuma Takumi, Tomita Hirofumi
CLINICAL CARDIOLOGY 44 ( 1 ) 91 - 99 2021年01月
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Characterizing genetic variants for DAG and IP3 signalling pathways in severe cases of coronary spastic angina
Shibutani S., Yonekura M., Nosaka M., Kawamura Y., Hanada K., Kasai S., Yokota T., Higuma T., Itoh K., Tomita H.
EUROPEAN HEART JOURNAL 41 1574 - 1574 2020年11月
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Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A patient-pooled meta-analysis of randomized clinical trials
Hoedemaker Niels P. G., Roolvink Vincent, de Winter Robbert J., van Royen Niels, Fuster Valentin, Garcia-Ruiz Jose M., Er Fikret, Gassanov Natig, Hanada Kenji, Okumura Ken, Ibanez Borja, van 't Hof Arnoud W., Damman Peter
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE 9 ( 5 ) 469 - 477 2020年08月
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Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice
Yokono Yoshikazu, Hanada Kenji, Narita Masato, Tatara Yota, Kawamura Yousuke, Miura Naotake, Kitayama Kazutaka, Nakata Masamichi, Nozaka Masashi, Kato Tomo, Kudo Natsumi, Tsushima Michiko, Toyama Yuichi, Itoh Ken, Tomita Hirofumi
JOURNAL OF THE AMERICAN HEART ASSOCIATION 9 ( 12 ) e015616 2020年06月
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前立腺癌で加療中にたこつぼ型心筋症を発症し，後にステロイド自己中断による副腎不全が判明した1例
酒井 峻太郎, 西崎 史恵, 遠藤 知秀, 澁谷 修司, 花田 賢二, 横田 貴志, 富田 泰史
心臓 52 ( 1 ) 70 - 74 2020年01月
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Mutational analysis of β-arrestin in Japanese patients with coronary spastic angina
Kudo Natsumi, Hanada Kenji, Kawamura Yosuke, Nakata Masamichi, Nozaka Masashi, Kitayama Kazutaka, Miura Naotake, Tanaka Makoto, Osanai Tomohiro
Hirosaki Medical Journal 70 ( 2-4 ) 148 - 155 2020年
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Incidence and clinical impact of thrombus after stent implantation in patients with ST-segment elevation myocardial infarction: an optical coherence tomography study
Kato Tomo, Yokota Takashi, Nishizaki Fumie, Hanada Kenji, Nozaka Masashi, Yamada Masahiro, Kudo Natsumi, Yokono Yoshikazu, Toyama Yuichi
Hirosaki Medical Journal 70 ( 2-4 ) 139 - 147 2020年
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Clinical Outcomes of Acute Myocardial Infarction Patients With a History of Malignant Tumor
Nozaka Masashi, Yokoyama Hiroaki, Kitayama Kazutaka, Nagawa Daiki, Hamadate Misato, Miura Naotake, Kawamura Yosuke, Nakata Masamichi, Nishizaki Fumie, Hanada Kenji, Yokota Takashi, Yamada Masahiro, Tomita Hirofumi
IN VIVO 34 ( 6 ) 3589 - 3595 2020年
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Prognostic impact of body mass index and culprit lesion calcification in patients with acute myocardial infarction.
Hiroaki Yokoyama, Takumi Higuma, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Takashi Yokota, Masahiro Yamada, Ken Okumura, Hirofumi Tomita
Heart and vessels 34 ( 12 ) 1909 - 1916 2019年12月
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Prognostic impact of body mass index and culprit lesion calcification in patients with acute myocardial infarction
Yokoyama Hiroaki, Higuma Takumi, Endo Tomohide, Nishizaki Fumie, Hanada Kenji, Yokota Takashi, Yamada Masahiro, Okumura Ken, Tomita Hirofumi
HEART AND VESSELS 34 ( 12 ) 1909 - 1916 2019年12月
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Blockade of protease activated receptor-1 signaling attenuates cardiac hypertrophy and fibrosis in renin-overexpressing hypertensive mice
Yokono Y., Narita M., Kawamura Y., Kato T., Kudo N., Tsushima M., Toyama Y., Hanada K., Shimada M., Makoto T., Osanai T., Tomita H.
EUROPEAN HEART JOURNAL 40 926 - 926 2019年10月
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Incidence and Outcomes of irregular protrusion after stent implantation in patients with acute myocardial infarction: An in in vivo optical coherence tomography study
Kato T., Higuma T., Yokota T., Kudo N., Yokono Y., Senoo M., Narita N., Endo T., Nishizaki F., Shibutani S., Hanada K., Tomita H.
EUROPEAN HEART JOURNAL 40 456 - 456 2019年10月
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IQGAP1 activates PLC-δ1 by direct binding and moving along microtubule with DLC-1 to cell surface.
Makoto Tanaka, Tomohiro Osanai, Yoshimi Homma, Kenji Hanada, Ken Okumura, Hirofumi Tomita
FASEB bioAdvances 1 ( 8 ) 465 - 480 2019年08月
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IQGAP1 activates PLC-d1 by direct binding and moving along microtubule with DLC-1 to cell surface
Tanaka Makoto, Osanai Tomohiro, Homma Yoshimi, Hanada Kenji, Okumura Ken, Tomita Hirofumi
FASEB BIOADVANCES 1 ( 8 ) 465 - 480 2019年08月
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Involvement of β-Arrestin in Endothelin Receptor Signaling: A Possible Role in the Pathogenesis of Pulmonary Arterial Hypertension
Narita Noritomo, Hanada Kenji, Senoo Maiko, Kato Tomo, Kudo Natsumi, Yokono Yoshikazu, Tsushima Michiko, Toyama Yuichi, Narita Masato
Hirosaki Medical Journal 69 ( 1-4 ) 146 - 154 2019年03月
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COMPLETE ATRIOVENTRICULAR BLOCK IS A POOR PROGNOSTIC COMPLICATION IN PATIENTS WITH ANTERIOR ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN THE ERA OF PRIMARY PERCUTANEOUS CORONARY INTERVENTION
Kawamura Yosuke, Higuma Takumi, Endo Tomohide, Nishizaki Fumie, Shibutani Shuji, Hanada Kenji, Yokoyama Hiroaki, Yokota Takashi, Yamada Masahiro, Tomita Hirofumi
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 73 ( 9 ) 84 - 84 2019年03月
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Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A patient-pooled meta-analysis of randomized clinical trials.
Niels Pg Hoedemaker, Vincent Roolvink, Robbert J de Winter, Niels van Royen, Valentin Fuster, José M García-Ruiz, Fikret Er, Natig Gassanov, Kenji Hanada, Ken Okumura, Borja Ibáñez, Arnoud W van 't Hof, Peter Damman
European heart journal. Acute cardiovascular care 2048872619830609 - 2048872619830609 2019年02月
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Prasugrel versus clopidogrel for residual thrombus burden in patients with ST-segment elevation myocardial infarction: an optical coherence tomography study.
Takashi Yokota, Takumi Higuma, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Hiroaki Yokoyama, Masahiro Yamada, Ken Okumura, Hirofumi Tomita
Coronary artery disease 29 ( 8 ) 663 - 669 2018年12月
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Prasugrel versus clopidogrel for residual thrombus burden in patients with ST-segment elevation myocardial infarction: an optical coherence tomography study
Yokota Takashi, Higuma Takumi, Endo Tomohide, Nishizaki Fumie, Hanada Kenji, Yokoyama Hiroaki, Yamada Masahiro, Okumura Ken, Tomita Hirofumi
CORONARY ARTERY DISEASE 29 ( 8 ) 663 - 669 2018年12月
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Carvedilol Suppresses Coronary Spasm in A-Kinase Anchoring Protein 150 Knockout Mice: Its Novel Therapeutic Role in Coronary Spastic Angina
Narita Noritomo, Hanada Kenji, Kawamura Yosuke, Nozaka Masashi, Kato Tomo, Kudo Natsumi, Yokono Yoshikazu, Senoo Maiko, Narita Masato, Tanaka Makoto, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi
CIRCULATION 138 2018年11月
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p122RhoGAP/DLC-1 Overexpression Enhances Intracellular Calcium Concentration and Causes Coronary Spasm: Potential Role for Coronary Spastic Angina
Kudo Natsumi, Kimura Yoshihiro, Hanada Kenji, Kato Tomo, Tsushima Michiko, Toyama Yuichi, Yokono Yoshikazu, Senoo Maiko, Narita Noritomo, Narita Masato, Yonekura Manabu, Ichikawa Hiroaki, Tanaka Makoto, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi
CIRCULATION 138 2018年11月
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Inhibitory Effects of Rivaroxaban, a Direct Factor Xa Inhibitor, on Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice
Narita Masato, Hanada Kenji, Yokono Yoshikazu, Senoo Maiko, Narita Noritomo, Kudo Natsumi, Kato Tomo, Nozaka Masashi, Kawamura Yosuke, Tanaka Makoto, Shimada Michiko, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi
CIRCULATION 138 2018年11月
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Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan.
Yoshihiro Kimura, Masahiro Yamada, Kenji Hanada, Tomohide Endo, Noritomo Narita, Masato Narita, Maiko Senoo, Manabu Yonekura, Hiroaki Ichikawa, Shizuka Kurauchi, Shigeyuki Nakaji, Ken Okumura, Hirofumi Tomita
International heart journal 59 ( 4 ) 736 - 740 2018年07月
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Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan Analysis of the Iwaki Health Promotion Project
Kimura Yoshihiro, Yamada Masahiro, Hanada Kenji, Endo Tomohide, Narita Noritomo, Narita Masato, Senoo Maiko, Yonekura Manabu, Ichikawa Hiroaki, Kurauchi Shizuka, Nakaji Shigeyuki, Okumura Ken, Tomita Hirofumi
Japanese Heart Journal 59 ( 4 ) 736 - 740 2018年07月
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Safety and efficacy of the subcutaneous cardioverter-defibrillator in patients at high risk of sudden cardiac death: Primary Japanese experience.
Sasaki Shingo, Tomita Hirofumi, Tsurugi Takuo, Ishida Yuji, Shoji Yoshihiro, Nishizaki Kimitaka, Kinjo Takahiko, Endo Tomohide, Nishizaki Fumie, Hanada Kenji, Sasaki Kenichi, Horiuchi Daisuke, Kimura Masaomi, Higuma Takumi, Okamatsu Hideharu, Tanaka Yasuaki, Koyama Junjiroh, Okumura Ken
日本循環器學誌 82 ( 6 ) 1546 - 1551 2018年05月
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Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gα<sub>i</sub> coupling.
Wang J, Hanada K, Gareri C, Rockman HA
Journal of cellular biochemistry 119 ( 4 ) 3586 - 3597 2018年04月
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"30-minute-delta" of high-sensitivity troponin I improves diagnostic performance in acute myocardial infarction.
Hiroaki Yokoyama, Takumi Higuma, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Takashi Yokota, Masahiro Yamada, Ken Okumura, Hirofumi Tomita
Journal of cardiology 71 ( 2 ) 144 - 148 2018年02月
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"30-minute-delta" of high-sensitivity troponin I improves diagnostic performance in acute myocardial infarction
Yokoyama Hiroaki, Higuma Takumi, Endo Tomohide, Nishizaki Fumie, Hanada Kenji, Yokota Takashi, Yamada Masahiro, Okumura Ken, Tomita Hirofumi
JOURNAL OF CARDIOLOGY 71 ( 1-2 ) 144 - 148 2018年
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Gα<sub>i</sub> is required for carvedilol-induced β<sub>1</sub> adrenergic receptor β-arrestin biased signaling.
Wang J, Hanada K, Staus DP, Makara MA, Dahal GR, Chen Q, Ahles A, Engelhardt S, Rockman HA
Nature communications 8 ( 1 ) 1706 2017年11月
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Mechanical Stretch Activates Biased AT1R Signaling and a Distinct [beta]-arrestin Conformation
Gareri Clarice, Wang Jialu, Hanada Kenji, Kashai Alem W., Xiong Xinyu, Rajagopal Sudarshan, Rockman Howard A.
CIRCULATION RESEARCH 121 2017年07月
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Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.
Pironti G, Strachan RT, Abraham D, Mon-Wei Yu S, Chen M, Chen W, Hanada K, Mao L, Watson LJ, Rockman HA
Circulation 131 ( 24 ) 2120 - 30 2015年06月
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Deeply reinverted T wave at 14 days after the onset of first anterior acute myocardial infarction predicts improved left ventricular function at 6 months.
Hiroaki Yokoyama, Hirofumi Tomita, Fumie Nishizaki, Kenji Hanada, Shuji Shibutani, Masahiro Yamada, Naoki Abe, Takumi Higuma, Tomohiro Osanai, Ken Okumura
Clinical cardiology 38 ( 3 ) 157 - 163 2015年03月
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Deeply Reinverted T Wave at 14 Days After the Onset of First Anterior Acute Myocardial Infarction Predicts Improved Left Ventricular Function at 6 Months
Yokoyama Hiroaki, Tomita Hirofumi, Nishizaki Fumie, Hanada Kenji, Shibutani Shuji, Yamada Masahiro, Abe Naoki, Higuma Takumi, Osanai Tomohiro, Okumura Ken
CLINICAL CARDIOLOGY 38 ( 3 ) 157 - 163 2015年03月
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Plasma soluble lectin-like oxidized low-density lipoprotein receptor-1 as a novel prognostic biomarker in patients with ST-segment elevation acute myocardial infarction.
Takumi Higuma, Naoki Abe, Syunta Tateyama, Tomohide Endo, Shuji Shibutani, Hiroaki Yokoyama, Kenji Hanada, Masahiro Yamada, Hirofumi Tomita, Hiroyuki Hanada, Tomohiro Osanai, Noriaki Kume, Ken Okumura
Circulation journal : official journal of the Japanese Circulation Society 79 ( 3 ) 641 - 648 2015年
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Plasma Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 as a Novel Prognostic Biomarker in Patients With ST-Segment Elevation Acute Myocardial Infarction
Higuma Takumi, Abe Naoki, Tateyama Syunta, Endo Tomohide, Shibutani Shuji, Yokoyama Hiroaki, Hanada Kenji, Yamada Masahiro, Tomita Hirofumi, Hanada Hiroyuki, Osanai Tomohiro, Kume Noriaki, Okumura Ken
日本循環器學誌 79 ( 3 ) 641 - 648 2015年
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PLAQUE RUPTURE IS ASOCIATED WITH WORSE REPERFUSION OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Higuma Takumi, Abe Naoki, Tateyama Shunta, Shibutani Shuji, Hanada Kenji, Yokoyama Hiroaki, Yamada Masahiro, Osanai Tomohiro, Okumura Ken
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 63 ( 12 ) A71 - A71 2014年04月
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Stent malapposition, as a potential mechanism of very late stent thrombosis after bare-metal stent implantation: a case report.
Takumi Higuma, Naoki Abe, Kenji Hanada, Hiroaki Yokoyama, Hirofumi Tomita, Ken Okumura
Cardiovascular revascularization medicine : including molecular interventions 15 ( 3 ) 178 - 181 2014年04月
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Stent malapposition, as a potential mechanism of very late stent thrombosis after bare-metal stent implantation: a case report.
Higuma T, Abe N, Hanada K, Yokoyama H, Tomita H, Okumura K
Cardiovascular revascularization medicine : including molecular interventions 15 ( 3 ) 178 - 81 2014年04月
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Follow-up Coronary Angiography at Chronic Phase is Beneficial in Patients With Acute Myocardial Infarction
Abe Naoki, Higuma Takumi, Tateyama Syunta, Endeo Tomohide, Hanada Kenji, Shibutani Syuji, Yokoyama Hiroaki, Yamada Masahiro, Tomita Hirofumi, Hanada Hiroyuki, Osanai Tomohiro, Okumura Ken
CIRCULATION 128 ( 22 ) 2013年11月
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The Incidence, Characteristics, And Outcome Of Cardiac Rupture In Patients With Acute Myocardial Infarction In The Primary PCI Era
Hanada Kenji, Higuma Takumi, Osanai Tomohiro, Okumura Ken
CIRCULATION 128 ( 22 ) 2013年11月
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Plasma Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-1 as a Novel Prognostic Biomaker in Patients With ST-elevation Acute Myocardial Infarction
Higuma Takumi, Abe Naoki, Tateyama Shunta, Endo Tomohide, Hanada Kenji, Shibutani Syuuji, Yamada Masahiro, Tomita Hirofumi, Hanada Hiroyuki, Osanai Tomohiro, Kume Noriaki, Okumura Ken
CIRCULATION 128 ( 22 ) 2013年11月
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Plasma Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Level at Admission can Predict Mortality in Patients with Acute Myocardial Infarction
Higuma Takumi, Abe Naoki, Endo Tomohide, Tateyama Shunta, Hanada Kenji, Yokoyama Hiroaki, Echizen Takashi, Yokota Takashi, Saito Shin, Tomita Hirofumi, Hanada Hiroyuki, Osanai Tomohiro, Kume Noriaki, Okumura Ken
CIRCULATION 126 ( 21 ) 2012年11月
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Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice.
Shigeki Sagara, Tomohiro Osanai, Taihei Itoh, Kei Izumiyama, Shuji Shibutani, Kenji Hanada, Hiroaki Yokoyama, Yuko Yamamoto, Takashi Yokota, Hirofumi Tomita, Koji Magota, Ken Okumura
Journal of hypertension 30 ( 4 ) 778 - 786 2012年04月
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Randomized study on the efficacy and safety of landiolol, an ultra-short-acting β1-adrenergic blocker, in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.
Kenji Hanada, Takumi Higuma, Fumie Nishizaki, Takanori Sukekawa, Takashi Yokota, Masahiro Yamada, Shin Saito, Motoi Kushibiki, Koichi Oikawa, Naoki Abe, Hirofumi Tomita, Tomohiro Osanai, Ken Okumura
Circulation journal : official journal of the Japanese Circulation Society 76 ( 2 ) 439 - 445 2012年04月
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Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice
Sagara Shigeki, Osanai Tomohiro, Itoh Taihei, Izumiyama Kei, Shibutani Shuji, Hanada Kenji, Yokoyama Hiroaki, Yamamoto Yuko, Yokota Takashi, Tomita Hirofumi, Magota Koji, Okumura Ken
JOURNAL OF HYPERTENSION 30 ( 4 ) 778 - 786 2012年04月
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Coronary vasospasm induced in transgenic mouse with increased phospholipase C-δ1 activity.
Shuji Shibutani, Tomohiro Osanai, Toshihiro Ashitate, Shigeki Sagara, Kei Izumiyama, Yuko Yamamoto, Kenji Hanada, Takashi Echizen, Hirofumi Tomita, Takeshi Fujita, Takeshi Miwa, Hiroaki Matsubara, Yoshimi Homma, Ken Okumura
Circulation 125 ( 8 ) 1027 - 1036 2012年02月
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Coronary Vasospasm Induced in Transgenic Mouse With Increased Phospholipase C-delta 1 Activity
Shibutani Shuji, Osanai Tomohiro, Ashitate Toshihiro, Sagara Shigeki, Izumiyama Kei, Yamamoto Yuko, Hanada Kenji, Echizen Takashi, Tomita Hirofumi, Fujita Takeshi, Miwa Takeshi, Matsubara Hiroaki, Homma Yoshimi, Okumura Ken
CIRCULATION 125 ( 8 ) 1027 - 1036 2012年02月
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Randomized study on the efficacy and safety of landiolol, an ultra-short-acting β1-adrenergic blocker, in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention
Hanada Kenji, Higuma Takumi, Nishizaki Fumie, Sukekawa Takanori, Yokota Takashi, Yamada Masahiro, Saito Shin, Kushibiki Motoi, Oikawa Koichi, Abe Naoki, Tomita Hirofumi, Osanai Tomohiro, Okumura Ken
日本循環器學誌 76 ( 2 ) 439 - 445 2012年
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Overexpression of Coupling Factor 6 Attenuates Exercise-Induced Physiological Cardiac Hypertrophy By Inhibiting Pi3k/akt Signaling in Mice
Sagara Shigeki, Osanai Tomihiro, Suzuki Akiko, Nishizaki Fumie, Sukekawa Takanori, Itoh Taihei, Izumiyama Kei, Shibutani Shuji, Hanada Kenji, Yamamoto Yuko, Yokoyama Hiroaki, Yokota Takashi, Tomita Hirofumi, Okumura Ken
CIRCULATION 124 ( 21 ) 2011年11月
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Inhibition of P38 MAP Kinase Attenuates Left Ventricular Hypertrophy and Inhibits Progression of Systolic Dysfunction on Pressure-Overload Induced Pathological Cardiac Hypertrophy in Mice
Hanada Kenji, Osanai Tomohiro, Sukekawa Takanori, Ohya Fumie, Izumiyama Kei, Sagara Shigeki, Ito Taihei, Yamamoto Yuko, Shibutani Shuji, Tomita Hirofumi, Okumura Ken
弘前醫學 62 ( 1 ) 18 - 26 2011年04月
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Mutation Analysis ABCC9 Gene in Japanese Patients with Coronary Spastic Angina
Shibutani Shuji, Osanai Tomohiro, Oya Humie, Sagara Shigeki, Izumiyama Kei, Yamamoto Yuko, Hanada Kenji, Tomita Hirofumi, Okumura Ken
弘前醫學 62 ( 1 ) 27 - 33 2011年04月
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p38 MAP kinase の抑制はマウスの圧負荷による病的心肥大を軽減し心機能低下を抑制する
花田 賢二, 長内 智宏, 祐川 誉徳, 大矢 史恵, 泉山 圭, 相樂 繁樹, 伊藤 太平, 山本 祐子, 渋谷 修司, 富田 泰史, 奥村 謙
弘前医学 62 ( 1 ) 18 - 26 2011年
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日本人冠攣縮性狭心症患者における ABCC9遺伝子変異の有無の解析
渋谷 修司, 長内 智宏, 大矢 史恵, 相樂 繁樹, 泉山 圭, 山本 祐子, 花田 賢二, 富田 泰史, 奥村 謙
弘前医学 62 ( 1 ) 27 - 33 2011年
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Overexpression of Coupling Factor 6 Attenuates Physiological Cardiac Hypertrophy Induced by Swimming and Causes Systolic Cardiac Dysfunction in Mice
Sagara Shigeki, Osanai Tomohiro, Itoh Taihei, Izumiyama Kei, Shibutani Shuji, Hanada Kenji, Yamamoto Yuko, Okumura Ken
CIRCULATION 122 ( 21 ) 2010年11月
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Overexpression of Coupling Factor 6 Causes Salt-Sensitive Hypertension and Systolic Cardiac Dysfunction: Gender as an Important Modulator
Izumiyama Kei, Osanai Tomohiro, Ashitate Toshihiro, Sagara Shigeki, Itoh Taihei, Shibutani Shuji, Hanada Kenji, Yamamoto Yuko, Okumura Ken
CIRCULATION 122 ( 21 ) 2010年11月
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Effects of telmisartan on markers of ventricular remodeling in patients with acute myocardial infarction: comparison with enalapril.
Takashi Yokota, Tomohiro Osanai, Kenji Hanada, Motoi Kushibiki, Naoki Abe, Koichi Oikawa, Hirofumi Tomita, Takumi Higuma, Jin Yokoyama, Hiroyuki Hanada, Ken Okumura
Heart and vessels 25 ( 6 ) 460 - 468 2010年11月
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Overexpression of coupling factor 6 causes cardiac dysfunction under high-salt diet in mice.
Toshihiro Ashitate, Tomohiro Osanai, Makoto Tanaka, Koji Magota, Takashi Echizen, Kei Izumiyama, Hiroaki Yokoyama, Shuji Shibutani, Kenji Hanada, Hirofumi Tomita, Ken Okumura
Journal of hypertension 28 ( 11 ) 2243 - 2251 2010年11月
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Effects of telmisartan on markers of ventricular remodeling in patients with acute myocardial infarction: comparison with enalapril
Yokota Takashi, Osanai Tomohiro, Hanada Kenji, Kushibiki Motoi, Abe Naoki, Oikawa Koichi, Tomita Hirofumi, Higuma Takumi, Yokoyama Jin, Hanada Hiroyuki, Okumura Ken
HEART AND VESSELS 25 ( 6 ) 460 - 468 2010年11月
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Overexpression of coupling factor 6 causes cardiac dysfunction under high-salt diet in mice
Ashitate Toshihiro, Osanai Tomohiro, Tanaka Makoto, Magota Koji, Echizen Takashi, Izumiyama Kei, Yokoyama Hiroaki, Shibutani Shuji, Hanada Kenji, Tomita Hirofumi, Okumura Ken
JOURNAL OF HYPERTENSION 28 ( 11 ) 2243 - 2251 2010年11月
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OE-070 Plasma Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-1 Level at Admission can Predict In-hospital Prognosis in Patients with Acute Myocardial Infarction(OE12,ACS/AMI (Clinical/Pathophysiology) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Higuma Takumi, Hanada Kenji, Abe Naoki, Oikawa Koichi, Kushibiki Motoi, Yokota Takashi, Yamamoto Yuko, Ohya Fumie, Hanada Hiroyuki, Osanai Tomohiro, Kume Noriaki, Okumura Ken
Circulation journal : official journal of the Japanese Circulation Society 73 ( 0 ) 191 2009年03月
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OJ-186 Efficacy and Safety of Landiolol, an Ultra Short-acting, β 1-selective Adrenergic Blocker, in Patients with Acute Myocardial Infarction Undergoing PCI(OJ31,ACS/AMI (Clinical/Treatment) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Hanada Kenji, Abe Naoki, Ohya Fumie, Sekiguchi Yuko, Yokota Takashi, Kushibiki Motoi, Oikawa Koichi, Higuma Takumi, Hanada Hiroyuki, Osanai Tomohiro, Okumura Ken
Circulation journal : official journal of the Japanese Circulation Society 73 ( 0 ) 332 - 333 2009年03月
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アミオダロンのマトリックスメタロプロテイナーゼ-2 活性に対する作用：ラット心筋梗塞モデルでの検討
堀内 大輔, 長内 智宏, 越前 崇, 芦立 俊宗, 加藤 千里, 横山 公章, 花田 賢二, 澁谷 修司, 伊藤 太平, 奥村 謙
弘前医学 60 ( 1-4 ) 45 - 53 2009年
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低酸素による心筋細胞 Insulin-like growth factor-1 遺伝子発現亢進の役割：心保護作用の機序について
加藤 千里, 長内 智宏, 渋谷 修司, 花田 賢二, 奥村 謙
弘前医学 60 ( 1-4 ) 36 - 44 2009年
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20)高度房室ブロックならびに流出路圧較差を生じたたこつぼ型心筋障害の一例(第144回日本循環器学会東北地方会)
相楽 繁樹, 樋熊 拓未, 花田 賢二, 澁谷 修司, 横田 貴志, 藤原 崇之, 阿部 直樹, 及川 広一, 富田 泰史, 木村 正臣, 佐々木 真吾, 横山 仁, 花田 裕之, 長内 智宏, 奥村 謙
71 ( 0 ) 984 2007年10月
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43)高齢のFallot修復術後に出現した左心不全に対し心臓再同期療法が有効であった1例(第143回日本循環器学会東北地方会)
渋谷 修司, 佐々木 真吾, 花田 賢二, 横田 貴志, 及川 広一, 阿部 直樹, 富田 泰史, 木村 正臣, 樋熊 拓未, 横山 仁, 花田 裕之, 長内 智宏, 奥村 謙
71 ( 0 ) 930 2007年10月
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21)心房梗塞によりアトロピン無効の徐脈低血圧をきたした1例(第143回日本循環器学会東北地方会)
花田 賢二, 樋熊 拓未, 渋谷 修司, 横田 貴志, 及川 広一, 阿部 直樹, 富田 泰史, 木村 正臣, 佐々木 真吾, 横山 仁, 花田 裕之, 長内 智宏, 奥村 謙
71 ( 0 ) 927 2007年10月
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Novel ferrochelatase mutations in Japanese patients with erythropoietic protoporphyria: High frequency of the splice site modulator IVS3-48C polymorphism in the Japanese population
Nakano Hajime, Nakano Aoi, Toyomaki Yuka, Ohashi Shigeki, Harada Ken, Moritsugu Ryuta, Takeda Hitoshi, Kawada Akira, Mitsuhashi Yoshihiko, Hanada Katsumi
JOURNAL OF INVESTIGATIVE DERMATOLOGY 126 ( 12 ) 2717 - 2719 2006年12月