Affiliation
Graduate School of Medicine Medical Science Course Physiology
KINOSHITA Masaharu
Degree
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博士（医学）
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修士（医科学）
Research Areas
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Life Science / Neuroscience-general
Professional Memberships
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日本生理学会
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日本神経科学学会
Papers
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Genetic dissection of the circuit for hand dexterity in primates.（共著）
Masaharu Kinoshita, Ryosuke Matsui, Shigeki Kato, Taku Hasegawa, Hironori Kasahara, Kaoru Isa, Akiya Watakabe, Tetsuo Yamamori, Yukio Nishimura, Bror Alstermark, Dai Watanabe, Kazuto Kobayashi, Tadashi Isa
Nature 487 ( 7406 ) 235 - 238 2012.7
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Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus
Masaharu Kinoshita, Rikako Kato, Kaoru Isa, Kenta Kobayashi, Kazuto Kobayashi, Hirotaka Onoe, Tadashi Isa
Nature Communications 10 ( 1 ) 135 - 135 2019.1
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Phylogenetic view of the compensatory mechanisms in motor and sensory systems after neuronal injury.
Isa T, Tohyama T, Kinoshita M
Current research in neurobiology 3 100058 - 100058 2022.10
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Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration.
Hung-Ya Tu, Takehito Watanabe, Hiroshi Shirai, Suguru Yamasaki, Masaharu Kinoshita, Keizo Matsushita, Tomoyo Hashiguchi, Hirotaka Onoe, Take Matsuyama, Atsushi Kuwahara, Akiyoshi Kishino, Toru Kimura, Mototsugu Eiraku, Kiyoshi Suzuma, Takashi Kitaoka, Masayo Takahashi, Michiko Mandai
EBioMedicine 39 562 - 574 2019.1
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Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys
Takamichi Tohyama, Masaharu Kinoshita, Kenta Kobayashi, Kaoru Isa, Dai Watanabe, Kazuto Kobayashi, Meigen Liu, Tadashi Isa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114 ( 3 ) 604 - 609 2017.1
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Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex
Akiya Watakabe, Masanari Ohtsuka, Masaharu Kinoshita, Masafumi Takaji, Kaoru Isa, Hiroaki Mizukami, Keiya Ozawa, Tadashi Isa, Tetsuo Yamamori
NEUROSCIENCE RESEARCH 93 144 - 157 2015.4
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Potential of optogenetics for the behavior manipulation of non-human primates
Masaharu Kinoshita, Tadashi Isa
Optogenetics: Light-Sensing Proteins and their Applications 271 - 290 2015.1
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DNA methylation and methyl-binding proteins control differential gene expression in distinct cortical areas of macaque monkey.（共著）
Katsusuke Hata, Hiroaki Mizukami, Osamu Sadakane, Akiya Watakabe, Masanari Ohtsuka, Masafumi Takaji, Masaharu Kinoshita, Tadashi Isa, Keiya Ozawa, Tetsuo Yamamori
The Journal of neuroscience 33 ( 50 ) 19704 - 19714 2013.12
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Role of Direct vs. Indirect Pathways from the Motor Cortex to Spinal Motoneurons in the Control of Hand Dexterity. （共著）
Tadashi Isa, Masaharu Kinoshita, Yukio Nishimura
Frontiers in neurology 4 191 - 191 2013.11
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Viral vector-mediated selective and reversible blockade of the pathway for visual orienting in mice.（共著）
Thongchai Sooksawate, Kaoru Isa, Ryosuke Matsui, Shigeki Kato, Masaharu Kinoshita, Kenta Kobayashi, Dai Watanabe, Kazuto Kobayashi, Tadashi Isa
Frontiers in neural circuits 7 162 - 162 2013.10
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Viral vector-mediated selective and reversible blockade of the pathway for visual orienting in mice
Thongchai Sooksawate, Kaoru Isa, Ryosuke Matsui, Shigeki Kato, Masaharu Kinoshita, Kenta Kobayashi, Dai Watanabe, Kazuto Kobayashi, Tadashi Isa
Frontiers in Neural Circuits 7 162 2013.10
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DNA methylation and methyl-binding proteins control differential gene expression in distinct cortical areas of macaque monkey
Katsusuke Hata, Hiroaki Mizukami, Osamu Sadakane, Akiya Watakabe, Masanari Ohtsuka, Masafumi Takaji, Masaharu Kinoshita, Tadashi Isa, Keiya Ozawa, Tetsuo Yamamori
Journal of Neuroscience 33 ( 50 ) 19704 - 19714 2013
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Viral vector-mediated selective and reversible blockade of the pathway for visual orienting in mice.
Sooksawate T, Isa K, Matsui R, Kato S, Kinoshita M, Kobayashi K, Watanabe D, Kobayashi K, Isa T
Frontiers in neural circuits 7 162 2013
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Role of direct vs. indirect pathways from the motor cortex to spinal motoneurons in the control of hand dexterity
Tadashi Isa, Masaharu Kinoshita, Yukio Nishimura
FRONTIERS IN NEUROLOGY 4 191 2013
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Genetic dissection of the circuit for hand dexterity in primates
Masaharu Kinoshita, Ryosuke Matsui, Shigeki Kato, Taku Hasegawa, Hironori Kasahara, Kaoru Isa, Akiya Watakabe, Tetsuo Yamamori, Yukio Nishimura, Bror Alstermark, Dai Watanabe, Kazuto Kobayashi, Tadashi Isa
NATURE 487 ( 7406 ) 235 - U1510 2012.7
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Optical imaging of contextual interactions in V1 of the behaving monkey.（共著）
Masaharu Kinoshita, Charles D Gilbert, Aniruddha Das
Journal of neurophysiology 102 ( 3 ) 1930 - 1944 2009.9
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Optical Imaging of Contextual Interactions in V1 of the Behaving Monkey
Masaharu Kinoshita, Charles D. Gilbert, Aniruddha Das
JOURNAL OF NEUROPHYSIOLOGY 102 ( 3 ) 1930 - 1944 2009.9
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Representation of surface luminance and brightness in macaque visual cortex.
Komatsu, H, Kinoshita, M
Neural Basis of Early Vision 74 - 74 2003
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Surface representation in the monkey primary visual cortex (VI)
H Komatsu, M Kinoshita
COGNITION AND EMOTION IN THE BRAIN 1250 ( C ) 53 - 61 2003
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Neural responses in the primary visual cortex of the monkey during perceptual filling-in at the blind spot
H Komatsu, M Kinoshita, Murakami, I
NEUROSCIENCE RESEARCH 44 ( 3 ) 231 - 236 2002.11
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Neural representation of the luminance and brightness of a uniform surface in the macaque primary visual cortex.（共著）
M Kinoshita, H Komatsu
Journal of neurophysiology 86 ( 5 ) 2559 - 2570 2001.11
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Neural representation of the luminance and brightness of a uniform surface in the macaque primary visual cortex
M Kinoshita, H Komatsu
JOURNAL OF NEUROPHYSIOLOGY 86 ( 5 ) 2559 - 2570 2001.11
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Stimulus time-locked responses of motoneurons during forelimb fictive locomotion evoked by repetitive stimulation of the lateral funiculus
M Kinoshita, T Yamaguchi
BRAIN RESEARCH 904 ( 1 ) 31 - 42 2001.6
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Neural responses in the retinotopic representation of the blind spot in the macaque V1 to stimuli for perceptual filling-in
H Komatsu, M Kinoshita, Murakami, I
JOURNAL OF NEUROSCIENCE 20 ( 24 ) 9310 - 9319 2000.12
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Perceptual filling-in at the scotoma following a monocular retinal lesion in the monkey
Murakami, I, H Komatsu, M Kinoshita
VISUAL NEUROSCIENCE 14 ( 1 ) 89 - 101 1997.1
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Surface representation in the visual system
H Komatsu, Murakami, I, M Kinoshita
BRAIN AND MIND 187 - 201 1997
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Surface representation in the visual system
H Komatsu, Murakami, I, M Kinoshita
COGNITIVE BRAIN RESEARCH 5 ( 1-2 ) 97 - 104 1996.12
Books
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Optogenetics - Light-Sensing Proteins and Their Applications（共著）
Yawo, Hiromu, Kandori, Hideki, Koizumi, Amane (Eds.) （ Role： Joint editor , Potential of Optogenetics for the Behavior Manipulation of Non-human Primates）
Springer 2015.7
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optogenetics
H. Kandori et al.（ Role： Joint author）
NTS Inc. 2013.4
Review Papers
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Optogenetic suppression of forelimb muscle activities in the behaving macaque monkey by introduction of microbial opsins in the primary motor cortex.
木下正治, 笠原洋紀, 畑中伸彦, 松井亮介, 知見聡美, 伊佐かおる, 水上浩明, 小澤敬也, 南部篤, 渡邉大, 伊佐正
第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会合同大会. P3-2-242, 京都 2013.6
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Selective blockade of crossed tecto-reticular pathway by double infection of viral vectors impaired orienting responses in mice; methodological considerations.
伊佐かおる, Thongchai Sooksawate, 松井亮介, 加藤成樹, 木下正治, 小林憲太, 渡邉大, 小林和人, 伊佐正
第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会合同大会. P1-2-244, 京都 2013.6
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Verified contribution of propriospinal neurons to recovery of hand dexterity after a corticospinal tract lesion in the monkey.
當山峰道, 木下正治, 松井亮介, 加藤成樹, 長谷川拓, 笠原洋紀, 伊佐かおる, 渡邉大, 小林和人, 里宇明元, 伊佐正
第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会合同大会. P1-1-74, 京都 2013.6
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ニューロサイエンスの最新情報 「霊長類の脳神経回路から特定の経路を選り分けて操作する「二重遺伝子導入法」」 （共著）
木下 正治、伊佐 正
Clinical Neuroscience 31 ( 3 ) 364 - 365 2013.3
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霊長類でのオプトジェネティクス （共著）
木下正治、伊佐 正
生体の科学 64 ( 1 ) 59 - 64 2013.2
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Optogenetics in primates
64 ( 1 ) 59 - 64 2013.1
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ウイルスベクター二重感染法による選択的神経伝達遮断により明らかにした、マカクザル前肢巧緻運動における脊髄固有ニューロンの機能.
木下正治, 松井亮介, 加藤成樹, 長谷川拓, 笠原洋紀, 伊佐かおる, 渡我部昭哉, 山森哲雄, 西村幸男, BrorAlstermark, 渡邉大, 小林和人, 伊佐正
第59回中部日本生理学会. P19, 岡崎 2012.11
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ウイルスベクター 2 重感染法によるマウス指向運動に関する神経経路の選択的・可逆的制御.
伊佐かおる, ThongchaiSooksawate, 木下正治, 松井亮介, 加藤成樹, 渡辺大, 小林和人, 伊佐正
第3回名古屋大学・生理学研究所合同シンポジウム, 岡崎 2012.9
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Genetic dissection of the spinal circuit for hand dexterity in macaque monkeys.
Masaharu Kinoshita, Ryosuke Matsui, Shigeki Kato, Taku Hasegawa, Hironori Kasahara, Kaoru Isa, Akiya Watakabe, Tetsuo Yamamori, Yukio Nishimura, Bror Alstermark, Dai Watanabe, Kazuto Kobayashi, Tadashi Isa
8th FENS Forum of Neuroscience. 155.04, Barcelona, Spain 2012.7
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ニューロサイエンスの最新情報 「オプトジェネティクスを用いた神経科学研究 」 （共著）
木下 正治、伊佐 正
Clinical Neuroscience 30 ( 1 ) 106 - 107 2012.1
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Expression of halorhodopsin for suppression of neuronal transmission in the central nervous system of the mouse and monkey with viral vectors.
Masaharu Kinoshita, Katsuyuki Kaneda, Hironori Kasahara, Nobuhiko Hatanaka, Ryosuke Matsui, Satomi Chiken, Kaoru Isa, Hiroaki Mizukami, Keiya Ozawa, Dai Watanabe, Atsushi Nambu, Tadashi Isa
第16回日本遺伝子治療学会. PO-104, 宇都宮 2010.7
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Optogenetically induced suppression of neural activity in the macaque motor cortex
Kinoshita, Masaharu, Kaneda, Katsuyuki, Kasahara, Hironori, Hatanaka, Nobuhiko, Matsui, Ryosuke, Chiken, Satomi, Isa, Kaoru, Mizukami, Hiroaki, Ozawa, Keiya, Watanabe, Dai, Nambu, Atsushi, Isa, Tadashi
NEUROSCIENCE RESEARCH 68 E149-E149 2010
Awards
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自然科学研究機構若手研究者賞
2013.06