Cloning of human Bach1 transcription factor which regulates transcription through NF-E2 site with small Maf proteins.

T Toki, R Kanezaki, K Arai, M Yokoyama, K Igarashi, M Yamamoto, E Ito

BLOOD   90 ( 10 )   196 - 196   1997.11

Antileukemic effect of azacitidine, a DNA methyltransferase inhibitor, on cell lines of myeloid leukemia associated with Down syndrome.

Tanaka T, Kudo K, Kanezaki R, Yuzawa K, Toki T, Okuse R, Kobayashi A, Sato T, Kamio T, Terui K, Ito E

Experimental hematology   104179   2024.2

Mutational analysis by targeted sequencing in 11 cases of tuberous sclerosis.

Yohei Yamamoto, Tatsuya Yamamoto, Ko Kudo, Tsutomu Toki, Rika Kanezaki, Tatsuya Ito, Tomoe Shinagawa, Arisa Asari, Hidenori Umetsu, Hiroshi Fujita, Etsuro Ito, and Kiminori Terui.

2023

BRAFV600E-positive cells as molecular markers of bone marrow disease in pediatric Langerhans cell histiocytosis.

Ko Kudo, Tsutomu Toki, Rika Kanezaki, Tatsuhiko Tanaka, Takuya Kamio, Tomohiko Sato, Shinya Sasaki, Masaru Imamura, Chihaya Imai, Kumiko Ando, Harumi Kakuda, Takehiko Doi, Hiroshi Kawaguchi, Masahiro Irie, Yoji Sasahara, Akihiro Tamura, Daiichiro Hasegawa, Yosuke Itakura, Kenichiro Watanabe, Kenichi Sakamoto, Yoko Shioda, Motohiro Kato, Kazuko Kudo, Reiji Fukano, Atsushi Sato, Hiroshi Yagasaki, Hirokazu Kanegane, Itaru Kato, Katsutsugu Umeda, Souichi Adachi, Tatsuki Kataoka, Akira Kurose, Atsuko Nakazawa, Kiminori Terui, Etsuro Ito

Haematologica   - ( 7 )   1719 - 1725   2022.7

Childhood acute myeloid leukemia with 5q deletion and HNRNPH1-MLLT10 fusion: The first case report.

Kudo K, Kubota Y, Toki T, Kanezaki R, Kobayashi A, Sato T, Kamio T, Sasaki S, Shiba N, Tomizawa D, Adachi S, Yoshida K, Ogawa S, Seki M, Takita J, Terui K

Blood advances   6 ( 10 )   3162 - 3166   2022.2

Dyserythropoietic anaemia with an intronic GATA1 splicing mutation in patients suspected to have Diamond-Blackfan anaemia

Akie Kobayashi, Ryusei Ohtaka, Tsutomu Toki, Junichi Hara, Hideki Muramatsu, Rika Kanezaki, Yuka Takahashi, Tomohiko Sato, Takuya Kamio, Ko Kudo, Shinya Sasaki, Taro Yoshida, Taiju Utsugisawa, Hitoshi Kanno, Kenichi Yoshida, Yasuhito Nannya, Yoshiyuki Takahashi, Seiji Kojima, Satoru Miyano, Seishi Ogawa, Kiminori Terui, Etsuro Ito

eJHaem   Volume 3 ( Issue 1 )   2022.1

Erythromelalgia presenting as recurrent purpura and hypogammaglobulinemia: A case report

Karasawa Takao, Hashimoto Shun, Sato Riko, Fujita Masashi, Aizawa Tomomi, Tsugawa Koji, Toki Tsutomu, Kanezaki Rika, Sato Tomohiko, Kudo Ko, Terui Kiminori, Tanaka Hiroshi

Hirosaki Medical Journal   72 ( 1-4 )   80 - 83   2022

BRAFV600E-positive precursors as molecular markers of bone marrow disease in LCH(和訳中)

工藤 耕, 土岐 力, 金崎 里香, 小林 明恵, 佐藤 知彦, 神尾 卓哉, 佐々木 伸也, 今村 勝, 今井 千速, 安藤 久美子, 角田 治美, 土居 岳彦, 川口 浩史, 入江 正寛, 笹原 洋二, 田村 彰広, 長谷川 大一郎, 板倉 陽介, 渡邉 健一郎, 深野 玲司, 坂本 謙一, 塩田 曜子, 加藤 元博, 工藤 寿子, 金兼 弘和, 伊藤 悦朗, 照井 君典

日本血液学会学術集会   83回   OS2 - 2   2021.9

Correction: Reduced-intensity conditioning is effective for hematopoietic stem cell transplantation in young pediatric patients with Diamond-Blackfan anemia.

Koyamaishi S, Kamio T, Kobayashi A, Sato T, Kudo K, Sasaki S, Kanezaki R, Hasegawa D, Muramatsu H, Takahashi Y, Sasahara Y, Hiramatsu H, Kakuda H, Tanaka M, Ishimura M, Nishi M, Ishiguro A, Yabe H, Sarashina T, Yamamoto M, Yuza Y, Hyakuna N, Yoshida K, Kanno H, Ohga S, Ohara A, Kojima S, Miyano S, Ogawa S, Toki T, Terui K, Ito E

Bone marrow transplantation   56 ( 5 )   1218 - 1219   2021.5

Reduced-intensity conditioning is effective for hematopoietic stem cell transplantation in young pediatric patients with Diamond–Blackfan anemia

Shun Koyamaishi, Takuya Kamio, Akie Kobayashi, Tomohiko Sato, Ko Kudo, Shinya Sasaki, Rika Kanezaki, Daiichiro Hasegawa, Hideki Muramatsu, Yoshiyuki Takahashi, Yoji Sasahara, Hidefumi Hiramatsu, Harumi Kakuda, Miyuki Tanaka, Masataka Ishimura, Masanori Nishi, Akira Ishiguro, Hiromasa Yabe, Takeo Sarashina, Masaki Yamamoto, Yuki Yuza, Nobuyuki Hyakuna, Kenichi Yoshida, Hitoshi Kanno, Shouichi Ohga, Akira Ohara, Seiji Kojima, Satoru Miyano, Seishi Ogawa, Tsutomu Toki, Kiminori Terui, Etsuro Ito

Bone Marrow Transplantation   56 ( 5 )   1013 - 1020   2021.5

Reduced-intensity conditioning is effective for hematopoietic stem cell transplantation in young pediatric patients with Diamond-Blackfan anemia.

Shun Koyamaishi, Takuya Kamio, Akie Kobayashi, Tomohiko Sato, Ko Kudo, Shinya Sasaki, Rika Kanezaki, Daiichiro Hasegawa, Hideki Muramatsu, Yoshiyuki Takahashi, Yoji Sasahara, Hidefumi Hiramatsu, Harumi Kakuda, Miyuki Tanaka, Masataka Ishimura, Masanori Nishi, Akira Ishiguro, Hiromasa Yabe, Takeo Sarashina, Masaki Yamamoto, Yuki Yuza, Nobuyuki Hyakuna, Kenichi Yoshida, Hitoshi Kanno, Shouichi Ohga, Akira Ohara, Seiji Kojima, Satoru Miyano, Seishi Ogawa, Tsutomu Toki, Kiminori Terui, Etsuro Ito

Bone marrow transplantation   2020.9

Highly sensitive detection of GATA1 mutations in patients with myeloid leukemia associated with Down syndrome by combining Sanger and targeted next generation sequencing.

Kiminori Terui, Tsutomu Toki, Takashi Taga, Shotaro Iwamoto, Takako Miyamura, Daisuke Hasegawa, Hiroshi Moritake, Asahito Hama, Kentaro Nakashima, Rika Kanezaki, Ko Kudo, Akiko M Saito, Keizo Horibe, Souichi Adachi, Daisuke Tomizawa, Etsuro Ito

Genes, chromosomes & cancer   59 ( 3 )   160 - 167   2020.3

Clinical, cytogenetic, and molecular analyses of 17 neonates with transient abnormal myelopoiesis and nonconstitutional trisomy 21.

Kentaro Yuzawa, Kiminori Terui, Tsutomu Toki, Rika Kanezaki, Akie Kobayashi, Tomohiko Sato, Takuya Kamio, Ko Kudo, Shinya Sasaki, Mikiya Endo, Shuichi Ozono, Keiko Nomura, Etsuro Ito

Pediatric blood & cancer   67 ( 4 )   e28188 - e28188   2020.2

BRAFV600E-Positive Precursors as Molecular Markers of Bone Marrow Involvement in Pediatric Langerhans Cell Histiocytosis

Kudo Ko, Kanezaki Rika, Masaru Imamura, Imai Chihaya, Irie Masahiro, Sasahara Yoji, Ando Kumiko, Kakuda Harumi, Doi Takehiko, Kawaguchi Hiroshi, Kudo Kazuko, Kanegane Hirokazu, Kobayashi Akie, Sato Tomohiko, Kamio Takuya, Sasaki Shinya, Terui Kiminori, Toki Tsutomu, Ito Etsuro

PEDIATRIC BLOOD & CANCER   66   S47   2019.12

Clinical and Molecular Cytogenetic Analysis of 15 Mosaic/Non-Down Syndrome Neonates With Transient Abnormal Myelopoiesis

Yuzawa Kentaro, Terui Kimnori, Toki Tsutomu, Kanezaki Rika, Kobayashi Akie, Sato Tomohiko, Kamio Takuya, Kudo Ko, Sasaki Shinya, Endo Mikiya, Ozono Shuichi, Ito Etsuro

PEDIATRIC BLOOD & CANCER   66   S35   2019.12

Comprehensive genetic analyses of relapsed B-cell precursor acute lymphoblastic leukemia in children

Kubo Kaori, Kudo Ko ,Toki Tsutomu, Kanezaki Rika, Ikeda Fumika, Ito Tatsuya, Kobayashi Akie, Sato Tomohiko, Kamio Takuya, Sasaki Shinya, Terui Kiminori, Ito Etsuro

Hirosaki Medical Journal   70 ( 1 )   13 - 23   2019.11

小児における前駆B細胞急性リンパ芽球性白血病の再発例を対象とした網羅的遺伝子解析(Comprehensive genetic analyses of relapsed B-cell precursor acute lymphoblastic leukemia in children)

Kubo Kaori, Kudo Ko, Toki Tsutomu, Kanezaki Rika, Ikeda Fumika, Ito Tatsuya, Kobayashi Akie, Sato Tomohiko, Kamio Takuya, Sasaki Shinya, Terui Kiminori, Ito Etsuro

弘前医学   70 ( 1 )   13 - 23   2019.11

ダウン症関連巨核芽球性白血病発症の分子機構

金崎　里香

BIO Clinica   34 ( 13 )   1345 - 1350   2019.10

TAMおよびDS-AMKL発症の分子機構

金崎　里香

BIO Clinica   34 ( 6 )   642 - 647   2019.5

Two siblings with familial neuroblastoma with distinct clinical phenotypes harboring an ALK germline mutation.

Kudo K, Ueno H, Sato T, Kubo K, Kanezaki R, Kobayashi A, Kamio T, Sasaki S, Terui K, Kurose A, Yoshida K, Shiozawa Y, Toki T, Ogawa S, Ito E.

Genes, chromosomes & cancer   2018.12

De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.

Tsutomu Toki, Kenichi Yoshida, RuNan Wang, Sou Nakamura, Takanobu Maekawa, Kumiko Goi, Megumi C Katoh, Seiya Mizuno, Fumihiro Sugiyama, Rika Kanezaki, Tamayo Uechi, Yukari Nakajima, Yusuke Sato, Yusuke Okuno, Aiko Sato-Otsubo, Yusuke Shiozawa, Keisuke Kataoka, Yuichi Shiraishi, Masashi Sanada, Kenichi Chiba, Hiroko Tanaka, Kiminori Terui, Tomohiko Sato, Takuya Kamio, Hirotoshi Sakaguchi, Shouichi Ohga, Madoka Kuramitsu, Isao Hamaguchi, Akira Ohara, Hitoshi Kanno, Satoru Miyano, Seiji Kojima, Akira Ishiguro, Kanji Sugita, Naoya Kenmochi, Satoru Takahashi, Koji Eto, Seishi Ogawa, Etsuro Ito

American journal of human genetics   103 ( 3 )   440 - 447   2018.9

Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia.

Fumika Ikeda, Kenichi Yoshida, Tsutomu Toki, Tamayo Uechi, Shiori Ishida, Yukari Nakajima, Yoji Sasahara, Yusuke Okuno, Rika Kanezaki, Kiminori Terui, Takuya Kamio, Akie Kobayashi, Takashi Fujita, Aiko Sato-Otsubo, Yuichi Shiraishi, Hiroko Tanaka, Kenichi Chiba, Hideki Muramatsu, Hitoshi Kanno, Shouichi Ohga, Akira Ohara, Seiji Kojima, Naoya Kenmochi, Satoru Miyano, Seishi Ogawa, Etsuro Ito

Haematologica   102 ( 3 )   e93 - e96   2017.3

ALDH2 polymorphism in patients with Diamond-Blackfan anemia in Japan.

Fumika Ikeda, Tsutomu Toki, Rika Kanezaki, Kiminori Terui, Kenichi Yoshida, Hitoshi Kanno, Shouichi Ohga, Akira Ohara, Seiji Kojima, Seishi Ogawa, Etsuro Ito

International journal of hematology   103 ( 1 )   112 - 114   2016.1

Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia.

RuNan Wang, Kenichi Yoshida, Tsutomu Toki, Takafumi Sawada, Tamayo Uechi, Yusuke Okuno, Aiko Sato-Otsubo, Kazuko Kudo, Isamu Kamimaki, Rika Kanezaki, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Kiminori Terui, Tomohiko Sato, Yuji Iribe, Shouichi Ohga, Madoka Kuramitsu, Isao Hamaguchi, Akira Ohara, Junichi Hara, Kumiko Goi, Kousaku Matsubara, Kenichi Koike, Akira Ishiguro, Yasuhiro Okamoto, Kenichiro Watanabe, Hitoshi Kanno, Seiji Kojima, Satoru Miyano, Naoya Kenmochi, Seishi Ogawa, Etsuro Ito

British journal of haematology   168 ( 6 )   854 - 864   2015.3

Gene alterations involving the CRLF2-JAK pathway and recurrent gene deletions in Down syndrome-associated acute lymphoblastic leukemia in Japan.

Isamu Hanada, Kiminori Terui, Fumika Ikeda, Tsutomu Toki, Rika Kanezaki, Tomohiko Sato, Takuya Kamio, Ko Kudo, Shinya Sasaki, Yoshihiro Takahashi, Yasuhide Hayashi, Takeshi Inukai, Seiji Kojima, Kenichi Koike, Yoshiyuki Kosaka, Masao Kobayashi, Masue Imaizumi, Tetsuo Mitsui, Hiroki Hori, Junichi Hara, Keizo Horibe, Jun-ichi Nagai, Hiroaki Goto, Etsuro Ito

Genes, chromosomes & cancer   53 ( 11 )   902 - 910   2014.11

Novel in-frame deletion of GATA1 observed in pediatric acute megakaryoblastic leukemia without Down syndrome

RuNab Wang, Rika Kanezaki, Tsutomu Toki, Kiminori Terui, Shinya Sakaki,Ko Kudo, Takuya Kamio, Tomohiko Sato, Fumika Ikeda, Ryo Araki, Hidetoshi Ochiai,Etsuro Ito

Hirosaki Medical Journal   65 ( 2-4 )   227 - 237   2014.9

Novel in-frame deletion of <i>GATA1</i> observed in pediatric acute megakaryoblastic leukemia without down syndrome

Wang RuNan, Kanezaki Rika, Toki Tsutomu, Terui Kiminori, Sasaki Shinya, Kudo Ko, Kamio Takuya, Sato Tomohiko, Ikeda Fumika, Araki Ryo, Ochiai Hidetoshi, Ito Etsuro

Hirosaki Medical Journal   65 ( 2-4 )   227 - 237   2014

The landscape of somatic mutations in Down syndrome-related myeloid disorders.

Kenichi Yoshida, Tsutomu Toki, Yusuke Okuno, Rika Kanezaki, Yuichi Shiraishi, Aiko Sato-Otsubo, Masashi Sanada, Myoung-ja Park, Kiminori Terui, Hiromichi Suzuki, Ayana Kon, Yasunobu Nagata, Yusuke Sato, RuNan Wang, Norio Shiba, Kenichi Chiba, Hiroko Tanaka, Asahito Hama, Hideki Muramatsu, Daisuke Hasegawa, Kazuhiro Nakamura, Hirokazu Kanegane, Keiko Tsukamoto, Souichi Adachi, Kiyoshi Kawakami, Koji Kato, Ryosei Nishimura, Shai Izraeli, Yasuhide Hayashi, Satoru Miyano, Seiji Kojima, Etsuro Ito, Seishi Ogawa

Nature genetics   45 ( 11 )   1293 - 1299   2013.11

Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome.

Tsutomu Toki, Rika Kanezaki, Eri Kobayashi, Hiroshi Kaneko, Mikiko Suzuki, Runan Wang, Kiminori Terui, Hirokazu Kanegane, Miho Maeda, Mikiya Endo, Tatsuki Mizuochi, Souichi Adachi, Yasuhide Hayashi, Masayuki Yamamoto, Ritsuko Shimizu, Etsuro Ito

Blood   121 ( 16 )   3181 - 3184   2013.4

Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia.

Takashi Yokoyama, Tsutomu Toki, Yoshihiro Aoki, Rika Kanezaki, Myoung-Ja Park, Yohei Kanno, Tomoko Takahara, Yukari Yamazaki, Etsuro Ito, Yasuhide Hayashi, Takuro Nakamura

Blood   119 ( 11 )   2608 - 2611   2012.3

Platelet-derived growth factor may be associated with fibrosis in a Down syndrome patient with transient myeloproliferative disorder

Jiro Ogawa, Hirokazu Kanegane, Koichi Tsuneyama, Rika Kanezaki, Takeshi Futatani, Keiko Nomura, Shin Ishizawa, Masakiyo Sasahara, Etsuro Ito, Toshio Miyawaki

EUROPEAN JOURNAL OF HAEMATOLOGY   81 ( 1 )   58 - 64   2008.7

Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome

Tomohiko Sato, Tsutomu Toki, Rika Kanezaki, Gang Xu, Kiminori Terui, Hirokazu Kanegane, Masayoshi Miura, Souichi Adachi, Masahiro Migita, Shingo Morinaga, Takahide Nakano, Mikiya Endo, Seiji Kojima, Hitoshi Kiyoi, Hiroyuki Mano, Etsuro Ito

BRITISH JOURNAL OF HAEMATOLOGY   141 ( 5 )   681 - 688   2008.6

A trial of isolating the novel genes on 21q11-21 to elucidate the gene responsible for transient abnormal myelopoiesis

Ishizaki Noriko, Kanezaki Rika, Toki Tsutomu, Ito Etsuro

Hirosaki Medical Journal   55 ( 3-4 )   83 - 94   2004

Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients

Tomomi Uyeda, Toru Takahashi, Shuji Eto, Takumi Sato, Gang Xu, Rika Kanezaki, Tsutomu Toki, Susumu Yonesaka, Etsuro Ito

Journal of Human Genetics   49 ( 8 )   404 - 407   2004

B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs.

Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, Ikebe D, Igarashi K, Ito E

Blood   102 ( 9 )   3317 - 3322   2003.11

Transgenic expression of BACH1 results in megakaryocytic linage impairement.

T Toki, F Katsuoka, R Kanezaki, T Kamio, S Tandai, H Kurotaki, S Yagihashi, K Igarashi, M Yamamoto, E Ito

BLOOD   100 ( 11 )   721A - 721A   2002.11