研究者詳細 - 古川　智範

論文 - 古川　智範

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Intranasal administration of trehalose reduces α-synuclein oligomers and accelerates α-synuclein aggregation

Tanaka, MT; Miki, Y; Mori, F; Kon, T; Furukawa, T; Shimoyama, S; Tatara, Y; Ozaki, T; Bettencourt, C; Warner, TT; Wakabayashi, K

BRAIN COMMUNICATIONS 6 ( 4 ) fcae193 2024年08月

Effects of voluntary and forced exercise on brain health in adult rats.

Sato C, Chiba M, Furukawa T, Koeda S, Mikami M, Hatakenaka K, Nunomura T, Umamichi K, Miura H, Yamada J.

Journal of Brain Science 2024年03月

Sex-related differences in the effect of exercise on protein profiles of serum in mice.

Furukawa T, Shimoyama S, Kobayashi A, Tatara Y, Nikaido Y, Ueno S

Hirosaki Medical Journal 74 2024年03月

Benzodiazepine-induced cell growth inhibition via GABAA receptor- and TSPO- independent pathways

Shimoyama S, Furukawa T, Ueno S

Hirosaki Medical Journal 74 2024年03月

Attempt to Develop Therapeutic Drug for Autism by Targeting IGF-1: Exploration of Small Compounds for IGF-1 Gene Expression

Nakamura, K; Shimoyama, S; Sakamoto, Y; Furukawa, T; Hasegawa, A; Shimizu, R; Kojima, H; Ueno, S

NEUROPSYCHOPHARMACOLOGY 48 128 - 128 2023年12月

Intranasal administration of trehalose reduces α-synuclein oligomers by accelerating aggregate formation in a mouse model of multiple system atrophy

Tanaka, M; Miki, Y; Mori, F; Furukawa, T; Shimoyama, S; Tatara, Y; Wakabayashi, K

BRAIN PATHOLOGY 33 2023年09月

Maternal taurine as a modulator of Cl- homeostasis as well as of glycine/GABAA receptors for neocortical development

Furukawa, T; Fukuda, A

FRONTIERS IN CELLULAR NEUROSCIENCE 17 1221441 - 1221441 2023年08月

Altered amantadine effects after repetitive treatment for l-dopa-induced involuntary movements in a rat model of Parkinson's disease.

Murakami Y, Nishijima H, Nakamura T, Furukawa T, Kinoshita I, Kon T, Suzuki C, Tomiyama M

Neuroscience letters 806 137248 - 137248 2023年05月

Effect of Ionizing Radiation on the Intercellular Network of Murine Cerebral Cortical Neurons

Yamaguchi Masaru, Tsujiguchi Takakiyo, Furukawa Tomonori, Shimoyama Shuji, Nakamura Toshiya, Mariya Yasushi, Yamada Junko

Radiation Environment and Medicine 12 ( 1 ) 65 - 73 2023年02月

Pathological substrate of memory impairment in multiple system atrophy.

Miki Y, Tanji K, Shinnai K, Tanaka MT, Altay F, Foti SC, Strand C, Sasaki T, Kon T, Shimoyama S, Furukawa T, Nishijima H, Yamazaki H, Asi YT, Bettencourt C, Jaunmuktane Z, Tada M, Mori F, Mizukami H, Tomiyama M, Lashuel HA, Lashley T, Kakita A, Ling H, Lees AJ, Holton JL, Warner TT, Wakabayashi K

Neuropathology and applied neurobiology 48 ( 7 ) e12844 2022年12月

IGF-1を標的とした自閉スペクトラム症治療薬の探索

下山修司, 古川智範, 坂本由唯, 長谷川敦史, 清水律子, 小島宏建, 上野伸哉, 中村和彦

日本脳科学会プログラム・抄録集 49回 35 - 35 2022年12月

GABAA受容体の細胞内分布におけるβ3サブユニットのリン酸化の影響

藤井萌加, 下山修司, 古川智範, 上野伸哉

日本生理学雑誌 84 ( 2 ) 35 - 35 2022年05月

ジアゼパム長期使用による海馬神経機能への影響

増山望, 古川智範, 二階堂義和, 下山修司, 能登谷綾香, 上野伸哉

日本生理学雑誌 84 ( 2 ) 36 - 36 2022年05月

The role of neutrophil gelatinase-associated lipocalin and iron homeostasis in object recognition impairment in aged sepsis-survivor rats.

Nikaido Y, Midorikawa Y, Furukawa T, Shimoyama S, Takekawa D, Kitayama M, Ueno S, Kushikata T, Hirota K

Scientific reports 12 ( 1 ) 249 - 249 2022年01月

Impaired Cognitive Function and Hippocampal Changes Following Chronic Diazepam Treatment in Middle-Aged Mice.

Furukawa T, Nikaido Y, Shimoyama S, Masuyama N, Notoya A, Ueno S

Frontiers in aging neuroscience 13 777404 - 777404 2021年11月

Copy number variations in Japanese children with autism spectrum disorder.

Yui Sakamoto, Shuji Shimoyama, Tomonori Furukawa, Masaki Adachi, Michio Takahashi, Tamaki Mikami, Michito Kuribayashi, Ayako Osato, Daiki Tsushima, Manabu Saito, Shinya Ueno, Kazuhiko Nakamura

Psychiatric genetics 31 ( 3 ) 79 - 87 2021年06月

GABAA Receptors and Maternally Derived Taurine Regulate the Temporal Specification of Progenitors of Excitatory Glutamatergic Neurons in the Mouse Developing Cortex.

Shiro Tochitani, Tomonori Furukawa, Ryo Bando, Shigeaki Kondo, Takashi Ito, Yoshitaka Matsushima, Toshio Kojima, Hideo Matsuzaki, Atsuo Fukuda

Cerebral cortex (New York, N.Y. : 1991) 2021年05月

GABAA Receptors and Maternally Derived Taurine Regulate the Temporal Specification of Progenitors of Excitatory Glutamatergic Neurons in the Mouse Developing Cortex.

Tochitani S, Furukawa T, Bando R, Kondo S, Ito T, Matsushima Y, Kojima T, Matsuzaki H, Fukuda A

Cerebral cortex (New York, N.Y. : 1991) 31 ( 10 ) 4554 - 4575 2021年05月

Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2.

Shuji Shimoyama, Tomonori Furukawa, Yoshiki Ogata, Yoshikazu Nikaido, Kohei Koga, Yui Sakamoto, Shinya Ueno, Kazuhiko Nakamura

PloS one 14 ( 9 ) e0222861 - e0222861 2019年09月

Phospholipase C-related inactive protein type-1 deficiency affects anesthetic electroencephalogram activity induced by propofol and etomidate in mice.

Furukawa T, Nikaido Y, Shimoyama S, Ogata Y, Kushikata T, Hirota K, Kanematsu T, Hirata M, Ueno S

Journal of anesthesia 33 ( 4 ) 531 - 542 2019年08月

Phospholipase C-related inactive protein type-1 deficiency affects anesthetic electroencephalogram activity induced by propofol and etomidate in mice.

Tomonori Furukawa, Yoshikazu Nikaido, Shuji Shimoyama, Yoshiki Ogata, Tetsuya Kushikata, Kazuyoshi Hirota, Takashi Kanematsu, Masato Hirata, Shinya Ueno

Journal of anesthesia 33 ( 4 ) 531 - 542 2019年07月

遺伝子Tspoの発現制御メカニズムの解明

下山修司, 古川智範, 小潟佳輝, 中村和彦, 上野伸哉

弘前医学 69 ( 1-4 ) 207 - 207 2019年03月

Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2.

Shimoyama S, Furukawa T, Ogata Y, Nikaido Y, Koga K, Sakamoto Y, Ueno S, Nakamura K

PloS one 14 ( 9 ) e0222861 2019年

〈一般演題抄録〉遺伝子Tspo の発現制御メカニズムの解明

下山修司, 古川智範, 小潟佳輝, 中村和彦, 上野伸哉

弘前医学 69 ( 1 ) 207 2019年

Anti‐hypersensitive effect of angiotensin (1‐7) on streptozotocin‐induced diabetic neuropathic pain in mice

Ogata Yoshiki, Nemoto Wataru, Yamagata Ryota, Nakagawasai Osamu, Shimoyama Shuji, Furukawa Tomonori, Ueno Shinya, Tan-No Koichi

European Journal of Pain 23 ( 4 ) 739 - 749 2018年11月

Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex.

Koga Kohei, Shimoyama Shuji, Yamada Akihiro, Furukawa Tomonori, Nikaido Yoshikazu, Furue Hidemasa, Nakamura Kazuhiko, Ueno Shinya.

Molecular Pain 14 ( 14 ) 1 - 14 2018年06月

MHC Class I in Dopaminergic Neurons Suppresses Relapse to Reward Seeking

Murakami Gen, Edamura Mitsuhiro, Furukawa Tomonori, Kawasaki Hideya, Kosugi Isao, Fukuda Atsuo, Iwashita Toshihide and Nakahara Daiichiro

Science Advances 2018年03月

MHC class I in dopaminergic neurons suppresses relapse to reward seeking.

Murakami G, Edamura M, Furukawa T, Kawasaki H, Kosugi I, Fukuda A, Iwashita T, Nakahara D

Science advances 4 ( 3 ) eaap7388 2018年03月

Propofol Anesthesia Is Reduced in Phospholipase C-Related Inactive Protein Type-1 Knockout Mice.

Nikaido Y, Furukawa T, Shimoyama S, Yamada J, Migita K, Koga K, Kushikata T, Hirota K, Kanematsu T, Hirata M, Ueno S

The Journal of pharmacology and experimental therapeutics 361 ( 3 ) 367 - 374 2017年06月

Propofol Anesthesia Is Reduced in Phospholipase C-Related Inactive Protein Type-1 Knockout Mice.

Nikaido Y, Furukawa T, Shimoyama S, Yamada J, Migita K, Koga K, Kushikata T, Hirota K, Kanematsu T, Hirata M, Ueno S.

J Pharmacol Exp Ther 361 ( 3 ) 367 - 374 2017年04月

Activations of muscarinic M1 receptors in the anterior cingulate cortex contribute to the antinociceptive effect via GABAergic transmission

Kohei Koga, Yu Matsuzaki, Kenji Honda, Fumihiro Eto, Tomonori Furukawa, Keisuke Migita, Keiichi Irie, Kenichi Mishima, Shinya Ueno

Molecular Pain 13 1 - 11 2017年02月

Chronic diazepam administration increases the expression of Lcn2 in the CNS

Tomonori Furukawa, Shuji Shimoyama, Yasuo Miki, Yoshikazu Nikaido, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi, Shinya Ueno

Pharmacology Research & Perspectives 5 ( 1 ) e00283 2017年01月

〈一般演題抄録〉うつ病モデルラットは内側前頭前野機能異常を起こす

二階堂義和, 古川智範, 下山修司, 古賀浩平, 上野伸哉

弘前医学 67 ( 2 ) 185 2017年

〈一般演題抄録〉ジアゼパム長期投与マウス脳組織のトランスクリプトーム解析

古川智範, 下山修司, 二階堂義和, 古賀浩平, 中村和彦, 上野伸哉

弘前医学 67 ( 2 ) 186 2017年

〈一般演題抄録〉ジアゼパム長期投与マウスにおける脳内 Lcn2 発現および認知機能の解析

古川智範, 二階堂義和, 下山修司, 三木康生, 古賀浩平, 中村和彦, 若林孝一, 上野伸哉

弘前医学 68 ( 1 ) 88 2017年

HSP90 Regulation of P2X7 Receptor Function Requires an Intact Cytoplasmic C-Terminus.

Keisuke Migita, Taku Ozaki, Shuji Shimoyama, Junko Yamada, Yoshikazu Nikaido, Tomonori Furukawa, Yuko Shiba, Terrance M Egan, Shinya Ueno

Molecular pharmacology 90 ( 2 ) 116 - 126 2016年08月

HSP90 Regulation of P2X7 Receptor Function Requires an Intact Cytoplasmic C-Terminus.

Migita K, Ozaki T, Shimoyama S, Yamada J, Nikaido Y, Furukawa T, Shiba Y, Egan TM, Ueno S

Molecular pharmacology 90 ( 2 ) 116 - 26 2016年08月

cis-3-Hexenol and trans-2-hexenal mixture prevents development of PTSD-like phenotype in rats.

Yoshikazu Nikaido, Junko Yamada, Keisuke Migita, Yuko Shiba, Tomonori Furukawa, Toshihiro Nakashima, Shinya Ueno

Behavioural brain research 297 251 - 258 2016年01月

cis-3-Hexenol and trans-2-hexenal mixture prevents development of PTSD-like phenotype in rats.

Nikaido Y, Yamada J, Migita K, Shiba Y, Furukawa T, Nakashima T, Ueno S

Behavioural brain research 297 251 - 8 2016年01月

GABAA 受容体応答の制御機構

上野伸哉, 古川智範, 二階堂義和, 下山修司, 柴祐子, 山田順子

弘前医学 66 ( 2 ) 105 - 109 2016年

Activity-dependent endogenous taurine release facilitates excitatory neurotransmission in the neocortical marginal zone of neonatal rats.

Qian T, Chen R, Nakamura M, Furukawa T, Kumada T, Akita T, Kilb W, Luhmann HJ, Nakahara D, Fukuda A

Frontiers in cellular neuroscience 8 33 2014年

Roles of taurine-mediated tonic GABAA receptor activation in the radial migration of neurons in the fetal mouse cerebral cortex.

Furukawa T, Yamada J, Akita T, Matsushima Y, Yanagawa Y, Fukuda A

Frontiers in cellular neuroscience 8 88 2014年

De Novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy.

Nakamura K, Kodera H, Akita T, Shiina M, Kato M, Hoshino H, Terashima H, Osaka H, Nakamura S, Tohyama J, Kumada T, Furukawa T, Iwata S, Shiihara T, Kubota M, Miyatake S, Koshimizu E, Nishiyama K, Nakashima M, Tsurusaki Y, Miyake N, Hayasaka K, Ogata K, Fukuda A, Matsumoto N, Saitsu H

American journal of human genetics 93 ( 3 ) 496 - 505 2013年09月

Cl⁻ homeodynamics in gap junction-coupled astrocytic networks on activation of GABAergic synapses.

Egawa K, Yamada J, Furukawa T, Yanagawa Y, Fukuda A

The Journal of physiology 591 ( 16 ) 3901 - 17 2013年08月

Guidepost neurons for the lateral olfactory tract: expression of metabotropic glutamate receptor 1 and innervation by glutamatergic olfactory bulb axons.

Tatsumi Hirata, Tatsuro Kumada, Takahiko Kawasaki, Tomonori Furukawa, Atsu Aiba, François Conquet, Yumiko Saga, Atsuo Fukuda

Developmental neurobiology 72 ( 12 ) 1559 - 1576 2012年12月

Guidepost neurons for the lateral olfactory tract: expression of metabotropic glutamate receptor 1 and innervation by glutamatergic olfactory bulb axons.

Hirata T, Kumada T, Kawasaki T, Furukawa T, Aiba A, Conquet F, Saga Y, Fukuda A

Developmental neurobiology 72 ( 12 ) 1559 - 76 2012年12月

Taurine inhibits K+-Cl- cotransporter KCC2 to regulate embryonic Cl- homeostasis via with-no-lysine (WNK) protein kinase signaling pathway.

Inoue K, Furukawa T, Kumada T, Yamada J, Wang T, Inoue R, Fukuda A

The Journal of biological chemistry 287 ( 25 ) 20839 - 50 2012年06月

The physiological roles of vesicular GABA transporter during embryonic development: a study using knockout mice.

Saito K, Kakizaki T, Hayashi R, Nishimaru H, Furukawa T, Nakazato Y, Takamori S, Ebihara S, Uematsu M, Mishina M, Miyazaki J, Yokoyama M, Konishi S, Inoue K, Fukuda A, Fukumoto M, Nakamura K, Obata K, Yanagawa Y

Molecular brain 3 40 2010年12月

Low-concentration tributyltin perturbs inhibitory synaptogenesis and induces neuronal death in immature but not mature neurons.

Yamada J, Inoue K, Furukawa T, Fukuda A

Toxicology letters 198 ( 2 ) 282 - 8 2010年10月

GABA imaging in brain slices using immobilized enzyme-linked photoanalysis.

Morishima T, Uematsu M, Furukawa T, Yanagawa Y, Fukuda A, Yoshida S

Neuroscience research 67 ( 4 ) 347 - 53 2010年08月

Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay.

Saitsu H, Tohyama J, Kumada T, Egawa K, Hamada K, Okada I, Mizuguchi T, Osaka H, Miyata R, Furukawa T, Haginoya K, Hoshino H, Goto T, Hachiya Y, Yamagata T, Saitoh S, Nagai T, Nishiyama K, Nishimura A, Miyake N, Komada M, Hayashi K, Hirai S, Ogata K, Kato M, Fukuda A, Matsumoto N

American journal of human genetics 86 ( 6 ) 881 - 91 2010年06月

Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex.

Yamada J, Furukawa T, Ueno S, Yamamoto S, Fukuda A

Cerebral cortex (New York, N.Y. : 1991) 17 ( 8 ) 1782 - 7 2007年08月

Insertion of alpha7 nicotinic receptors at neocortical layer V GABAergic synapses is induced by a benzodiazepine, midazolam.

Yamamoto S, Yamada J, Ueno S, Kubota H, Furukawa T, Yamamoto S, Fukuda A

Cerebral cortex (New York, N.Y. : 1991) 17 ( 3 ) 653 - 60 2007年03月

GABA-A receptors regulate neocortical neuronal migration in vitro and in vivo.

Heck N, Kilb W, Reiprich P, Kubota H, Furukawa T, Fukuda A, Luhmann HJ

Cerebral cortex (New York, N.Y. : 1991) 17 ( 1 ) 138 - 48 2007年01月

Differential expression of KCC2 accounts for the differential GABA responses between relay and intrinsic neurons in the early postnatal rat olfactory bulb.

Wang C, Ohno K, Furukawa T, Ueki T, Ikeda M, Fukuda A, Sato K

The European journal of neuroscience 21 ( 5 ) 1449 - 55 2005年03月

Brain oxytocin augments stress-induced long-lasting plasma adrenocorticotropic hormone elevation in rats.

Nakashima T, Noguchi T, Furukawa T, Yamasaki M, Makino S, Miyata S, Kiyohara T

Neuroscience letters 321 ( 3 ) 161 - 4 2002年03月

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