Affiliation
Health Sciences Health Sciences(Doctoral Course) Department of Radiation Science
Saga Ryo
Degree
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博士（保健学）
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修士（保健学）
Campus Career
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Hirosaki University Health Sciences Health Sciences(Doctoral Course) Department of Radiation Science Assistant Professor
2016.04 ～ Now
Research Areas
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Life Science / Radiological sciences
Professional Memberships
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日本分子生物学会
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Educational symposium on radiation and health by young socientists steering commitie
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The japanese radiation research society
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日本分子生物学会
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公益社団法人日本放射線腫瘍学会
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一般社団法人日本放射線影響学会
Papers
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Risk Assessment of Cataract Development in Radiotherapy for Patients with Brain Tumors and Head and Neck Cancer
Saga Ryo, Okabe Haruka, Obara Hideki, Komai Fumio, Osanai Minoru, Aoki Masahiko, Hosokawa Yoichiro
Radiation Environment and Medicine 13 ( 2 ) 45 - 51 2024.8
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Generality assessment of a model considering heterogeneous cancer cells for predicting tumor control probability for stereotactic body radiotherapy against non-small cell lung cancer
Ryo Saga, Yusuke Matsuya, Hideki Obara, Fumio Komai, Hironori Yoshino, Masahiko Aoki, Yoichiro Hosokawa
Advances in Radiation Oncology 101437 - 101437 2024.1
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Are Online Simulations for Radiation Emergency Medical Preparedness Less Effective in Teaching Than Face-to-Face Simulations?
Toshiko Tomisawa, Shota Hosokawa, Hiromi Kudo, Minoru Osanai, Kazuki Ota, Naoya In, Ayako Ohgino, Takakiyo Tsujiguchi, Shizuka Takamagi, Ryoko Tsuchiya, Maiko Kitajima, Shingo Terashima, Masaru Yamaguchi, Ryo Saga, Kasumi Mikami, Mayumi Urushizaka, Mioko Sakai, Keiko Aizu, Yoichiro Hosokawa, Hiroyuki Hanada
Disaster Medicine and Public Health Preparedness 17 e520 2023.10
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Fundamental evaluation of dose and dose distribution under applied topical agents and dressings used for skin care in radiotherapy
Hikari Sato, Ryo Saga, Fumio Komai, Yumiko Sato, Hideki Obara, Masahiko Aoki, Yoichiro Hosokawa
Journal of Radiation Research and Applied Sciences 16 ( 3 ) 2023.9
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Biophysical Simulations for Estimating Biological Effects after Exposure to Ionizing Radiation: Current State and Future Prospects
Matsuya Yusuke, Saga Ryo
Radiation Environment and Medicine 12 ( 2 ) 81 - 90 2023.8
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Translational study for stereotactic body radiotherapy against non-small cell lung cancer, including oligometastases, considering cancer stem-like cells enable predicting clinical outcome from in vitro data
Ryo Saga, Yusuke Matsuya, Hikari Sato, Kazuki Hasegawa, Hideki Obara, Fumio Komai, Hironori Yoshino, Masahiko Aoki, Yoichiro Hosokawa
Radiotherapy and Oncology 181 109444 - 109444 2023.4
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Modelling oxygen effects on the in- and out-of-field radiosensitivity of cells exposed to intensity-modulated radiation fields
Yusuke Matsuya, Stephen J McMahon, Karl T Butterworth, Yoshie Yachi, Ryo Saga, Tatsuhiko Sato, Kevin M Prise
Physics in medicine and biology 68 ( 9 ) 2023.3
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Radiotherapeutic Review: Acquisition of Radioresistance and Cancer Stem Cell Properties via Irradiation
Hasegawa* Kazuki, Saga Ryo, Hosokawa Yoichiro
Radiation Environment and Medicine 12 ( 1 ) 25 - 36 2023.2
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DNA‑PKcs phosphorylation specific inhibitor, NU7441, enhances the radiosensitivity of clinically relevant radioresistant oral squamous cell carcinoma cells.
Ohuchi K, Saga R, Hasegawa K, Tsuruga E, Hosokawa Y, Fukumoto M, Okumura K
Biomedical reports 18 ( 4 ) 28 - 28 2023.2
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4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression
Kazuki Hasegawa, Ryo Saga, Kentaro Ohuchi, Yoshikazu Kuwahara, Kazuo Tomita, Kazuhiko Okumura, Tomoaki Sato, Manabu Fukumoto, Eichi Tsuruga, Yoichiro Hosokawa
Cells 11 ( 23 ) 3780 - 3780 2022.11
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癌の放射線抵抗性と幹細胞特性の獲得および数理モデルによる複合的アプローチ
嵯峨涼、長谷川和輝、細川洋一郎
放射線生物研究 57 ( 2 ) 132 - 151 2022.7
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Training of Medical Responders to Nuclear Disaster: Hybrid Program in the COVID-19 Pandemic
Toshiko Tomisawa, Naoya In, Kazuki Ota, Takakiyo Tsujiguchi, Hiromi Kudo, Minoru Osanai, Kasumi Mikami, Shota Hosokawa, Shingo Terashima, Maiko Kitajima, Ryo Saga, Masaru Yamaguchi, Ryoko Tsuchiya, Mayumi Urushizaka, Yoichiro Hosokawa, Hiroyuki Hanada
Disaster Medicine and Public Health Preparedness 4 1 - 12 2022.3
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Identification of novel prognostic factors focusing on clinical outcomes in patients with non-small cell lung cancer after stereotactic body radiotherapy.
Hikari Sato, Fumiki Ito, Kazuki Hasegawa, Ryo Saga, Yoichiro Hosokawa, Mitsuki Tanaka, Masahiko Aoki
Oncology letters 23 ( 3 ) 79 - 79 2022.3
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Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability
Roman Fukui, Ryo Saga, Yusuke Matsuya, Kazuo Tomita, Yoshikazu Kuwahara, Kentaro Ohuchi, Tomoaki Sato, Kazuhiko Okumura, Hiroyuki Date, Manabu Fukumoto, Yoichiro Hosokawa
Scientific Reports 12 ( 1 ) 1056 2022.1
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4-Methylumbelliferone administration enhances radiosensitivity of human fibrosarcoma by intercellular communication
Ryo Saga, Yusuke Matsuya, Rei Takahashi, Kazuki Hasegawa, Hiroyuki Date, Yoichiro Hosokawa
Scientific Reports 11 ( 1 ) 8258 2021.12
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The Clinical Usefulness of Water/Iodine Material Density Measured by DE-CT
Hasegawa Kazuki, Saga Ryo, Sato Yuta, Tanaka Mitsuki, Katagishi Ryo, Aoki Masahiko, Hosokawa Yoichiro
Radiation Environment and Medicine 10 ( 2 ) 82 - 86 2021.8
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Radiation Safety and Public Health for Radiological Professionals: Meeting Report on The 5th Educational Symposium on Radiation and Health (ESRAH) by Young Scientists in 2018
Hiroko Yamashina, Marin Terashima, Joma Oikawa, Shingo Naijo, Tamao Miyao, Yoshie Yachi, Yusuke Matsuya, Masaru Yamaguchi, Takakiyo Tsujiguchi, Ryo Saga, Hu Jun, Goh Valerie Swee Ting, Toshiya Nakamura, Yoichiro Hosokawa, Hiroyuki Date
Radiation Environment and Medicine 10 ( 1 ) 48 - 54 2021.6
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Oxygen enhancement ratios of cancer cells after exposure to intensity modulated x-ray fields: DNA damage and cell survival
Yusuke Matsuya, Stephen J McMahon, Karl T Butterworth, Shingo Naijo, Isshi Nara, Yoshie Yachi, Ryo Saga, Masayori Ishikawa, Tatsuhiko Sato, Hiroyuki Date, Kevin M Prise
Physics in Medicine & Biology 66 ( 7 ) 075014 - 075014 2021.4
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Matrix Metalloproteinase-2 Activated by Ultraviolet-B Degrades Human Ciliary Zonules <i>In Vitro</i>
Shiroto Yuki, Saga Ryo, Yoshino Hironori, Hosokawa Yoichiro, Isokawa Keitaro, Tsuruga Eichi
ACTA HISTOCHEMICA ET CYTOCHEMICA 54 ( 1 ) 1 - 9 2021.2
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The clinical usefulness of Water/Iodine material density measured by DE-CT
Kazuki Hasegawa, Ryo Saga, Yuta Sato, Mitsuki Tanaka, Ryo Katagishi, Masahiko Aoki, Yoichiro Hosokawa
Radiation Environment and Medicine 10 ( 2 ) 2021
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Radiation Safety and Public Health for Radiological Professionals: Meeting Report on The 5<sup>th</sup> Educational Symposium on Radiation and Health (ESRAH) by Young Scientists in 2018
Yamashina Hiroko, Terashima Marin, Oikawa Joma, Naijo Shingo, Miyao Tamao, Yachi Yoshie, Matsuya Yusuke, Yamaguchi Masaru, Tsujiguchi Takakiyo, Saga Ryo, Jun Hu, Goh Valerie Swee Ting, Nakamura Toshiya, Hosokawa Yoichiro, Date Hiroyuki
Radiation Environment and Medicine 10 ( 1 ) 48 - 54 2021
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4-methylumbelliferone inhibits clonogenic potency by suppressing high molecular weight-hyaluronan in fibrosarcoma cells.
Kazuki Hasegawa, Ryo Saga, Rei Takahashi, Roman Fukui, Mitsuru Chiba, Kazuhiko Okumura, Eichi Tsuruga, Yoichiro Hosokawa
Oncology letters 19 ( 4 ) 2801 - 2808 2020.4
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放射線治療に関わる癌幹細胞
細川洋一郎、嵯峨涼、長谷川和輝、大内健太郎、奥村一彦
保健科学研究 10 ( 2 ) 2020.3
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4-methylumbelliferone inhibits clonogenic potency by suppressing high molecular weight-hyaluronan in fibrosarcoma cells
Kazuki Hasegawa, Ryo Saga, Rei Takahashi, Roman Fukui, Mitsuru Chiba, Kazuhiko Okumura, Eichi Tsuruga, Yoichiro Hosokawa
Oncology Letters 2020.2
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X線照射がラット肺胞線維芽細胞のエラスチンへ及ぼす影響
北山義尚, 白戸佑貴, 椎谷賢, 嵯峨涼, 寺島真悟, 細川洋一郎, 敦賀英知
保健科学研究 10 ( 1 ) 19 - 24 2019.9
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Apoptotic Induction Mechanism of X-ray Irradiation Combined with Hydrogen Peroxide
Fujita Satoshi, Hosokawa Yoichiro, Saga Ryo, Tsuruga Eichi, Okumura Kazuhiko, Ohuchi Kentaro, Ochi Morio
Radiation Environment and Medicine 8 ( 2 ) 85 - 93 2019.9
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Understanding the mechanism underlying the acquisition of radioresistance in human prostate cancer cells.
Kosho Murata, Ryo Saga, Satoru Monzen, Echi Tsuruga, Kazuki Hasegawa, Yoichiro Hosokawa
Oncology letters 17 ( 6 ) 5830 - 5838 2019.6
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Analysis of the high-dose-range radioresistance of prostate cancer cells, including cancer stem cells, based on a stochastic model.
Ryo Saga, Yusuke Matsuya, Rei Takahashi, Kazuki Hasegawa, Hiroyuki Date, Yoichiro Hosokawa
Journal of radiation research 60 ( 3 ) 298 - 307 2019.5
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Regulation of radiosensitivity by 4-methylumbelliferone via the suppression of interleukin-1 in fibrosarcoma cells.
Ryo Saga, Kazuki Hasegawa, Kosho Murata, Mitsuru Chiba, Toshiya Nakamura, Kazuhiko Okumura, Eichi Tsuruga, Yoichiro Hosokawa
Oncology letters 17 ( 3 ) 3555 - 3561 2019.2
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Radio-resistance analysis in high-dose range of prostate cancer cells including cancer stem cells based on a stochastic model
Ryo Saga, Yusuke Matsuya, Rei Takahashi, Kazuki Hasegawa, Hiroyuki Date, Yoichiro Hosokawa
Journal of Radiation Research 2019 1 - 10 2019
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Meeting Report on "The 4th Educational Symposium on Radiation and Health (ESRAH) by Young Scientists in 2017"
Ryo Saga, Takakiyo Tsujiguchi, Masaru Yamaguchi, Yasuyo Fukushi, Yohei Fujishima, Yusuke Matsuya, Joma Oikawa, Marin Terashima, Hiroyuki Date, Toshiya Nakamura, Yoichiro Hosokawa
Radiation environment and medicine : covering a broad scope of topics relevant to environmental and medical radiation research 7 ( 2 ) 121 - 124 2018.8
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Educational Activity for the Radiation Emergency System in the Northern Part of Japan: Meeting Report on "The 3rd Educational Symposium on Radiation and Health (ESRAH) by Young Scientists in 2016".
Yusuke Matsuya, Takakiyo Tsujiguchi, Masaru Yamaguchi, Takaaki Kimura, Ryosuke Mori, Ryota Yamada, Ryo Saga, Yohei Fujishima, Hiroyuki Date
Radiation research 187 ( 6 ) 641 - 646 2017.6
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Anti-tumor and anti-invasion effects of a combination of 4-methylumbelliferone and ionizing radiation in human fibrosarcoma cells.
Ryo Saga, Satoru Monzen, Mitsuru Chiba, Hironori Yoshino, Toshiya Nakamura, Yoichiro Hosokawa
Oncology letters 13 ( 1 ) 410 - 416 2017.1
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Ascorbic acid does not reduce the anticancer effect of radiotherapy.
Yoichiro Hosokawa, Ryo Saga, Satoru Monzen, Shingo Terashima, Eichi Tsuruga
Biomedical reports 6 ( 1 ) 103 - 107 2017.1
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Report on Radiation Emergency Medicine Education and Training Course
Ryo Saga, Yoichiro Hosokawa, Yoko Saito, Chieko Itaki, Toshiya Nakamura
Radiation Environment and Medicine 5 ( 2 ) 50 - 55 2016.8
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Investigation of γ-ray Dose Rate in Air at Densely-inhabited District in Fukushima Prefecture
Yosuke Suzuki, Takuya Harada, Yuriko Moro, Wakana Hozumi, Yoshitaka Shiroma, Ryo Saga, Yoichiro Hosokawa
Radiation Environment and Medicine 5 ( 2 ) 33 - 38 2016.8
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Effects of X‑ray irradiation in combination with ascorbic acid on tumor control.
Yoichiro Hosokawa, Satoru Monzen, Hironori Yoshino, Shingo Terashima, Manabu Nakano, Keisuke Toshima, Ryo Saga, Ikuo Kashiwakura
Molecular medicine reports 12 ( 4 ) 5449 - 54 2015.10
Books
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放射線安全管理学
飯本武志, 細田正洋, 真田哲也, 門前暁, 吉永信治, 安田成臣, 山内浩司, 齋藤美希, 伊藤茂樹, 横山須美, 阪間稔, 辻口貴清, 小山内暢, 高橋康幸, 杉野雅人, 寺島真悟, 諸澄邦彦, 西原貞光, 坂本肇, 五反田龍宏, 高木昭浩, 椎葉拓郎, 亀澤秀美, 川村愼二, 勘崎貴雄, 吉野浩教, 山口平, 嵯峨涼（ Role： Contributor）
株式会社 南江堂 2023.11
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放射線安全管理学[電子版付]
高橋, 康幸, 杉野, 雅人, 細田, 正洋（ Role： Contributor）
南江堂 2023.11
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非密封放射性同位元素取扱の基礎
門前暁、齋藤美希、中原岳久、森野議比古、吉野浩教、細川翔太、辻口貴清、小倉巧也、嵯峨涼、寺島真悟（ Role： Sole author）
弘前大学出版会 2021.3
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非密封放射性同位元素取扱の基礎
弘前大学大学院保健学研究科放射線技術科学領域（ Role： Contributor）
弘前大学出版会 2021.3
Awards
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弘前大学若手優秀論文賞
2024.12
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ERRS Young Investigator Award
2022.09
Social Activities
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原子力災害時医療中核人材研修（弘前大学）
2018.11
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原子力災害医療派遣チームに係る専門研修
2018.10
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原子力災害時医療中核人材研修
2018.09
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原子力災害医療派遣チームに係る専門研修（宮城県）
2018.09
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原子力災害医療派遣チームに係る専門研修（青森県）
2018.09
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Dシャトルの測定結果等に関する説明会
2016.11
Media Coverage
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がん放射線治療の効果を予測 弘前大など研究G成功、世界初
2023.02.25
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放射線治療の効果 正確な予測に成功 世界初 （青森県）
2023.02.24
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肺がん放射線治療の効果を正確に予測 弘前大
2023.02.24
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【弘前大学】世界初！がん幹細胞の考慮により臨床の放射線 治療効果の予測に成功 -- 基礎細胞実験と臨床研究をつなぐ予 測モデルを開発
2023.02.14
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［弘前大学］世界初！がん幹細胞の考慮により臨床の放射線治療効果の予測に成功 -- 基礎細胞実験と臨床研究をつなぐ予測モデルを開発（Digital PR Platform）
2023.02.14
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がん幹細胞の考慮により臨床の放射線治療効果の予測に成功～基礎細胞実験と臨床研究をつなぐ予測モデルを開発～
2023.02.14
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【弘前大学】世界初！がん幹細胞の考慮により臨床の放射線治療効果の予測に成功 -- 基礎細胞実験と臨床研究をつなぐ予測モデルを開発
2023.02.14
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【弘前大学】世界初！がん幹細胞の考慮により臨床の放射線治療効 果の予測に成功 -- 基礎細胞実験と臨床研究をつなぐ予測モデルを 開発
2023.02.14
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世界初！がん幹細胞の考慮により臨床の 放射線治療効果の予測に成功 ―基礎細胞実験と臨床研究をつなぐ予測モデルを開発―
2023.02