論文 - 嵯峨 涼
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Stromal-derived high-molecular-weight hyaluronan mediates radioresistance in the prostate cancer microenvironment.
Saga R, Iwamori K, Hosokawa Y
International journal of radiation biology 102 ( 2 ) 138 - 144 2026年
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Equivalent relative biological effectiveness for cell survival and micronuclei formation: insights from a biophysical approach.
Matsuya Y, Saga R, Wang Y, Sato T
Medical physics 52 ( 10 ) e70040 2025年10月
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Collaborative Seminar at Hirosaki University with Korea Institute of Radiological and Medical Sciences (KIRAMS) and Chang Gung Memorial Hospital (CGMH)
Hosoda Masahiro, Jeong Geum-cheol, Seong Ki Moon, Yang Susan, Lee Seung Bum, Jeong Jaemin, Cho Minsu, Kuo Chin-I, Chen Po-Cheng, Lin Chih-Chuan, Hanada Hiroyuki, Yamaguchi Masaru, In Naoya, Ohta Kazuki, Tsuchiya Ryoko, Saga Ryo, Takamagi Shizuka, Hosokawa Shota, Terashima Shingo, Osanai Minoru, Mikami Kasumi, Kudo Hiromi, Aizu Keiko, Kitajima Maiko, Urushizaka Mayumi, Tomisawa Toshiko, Anderson Donovan, Yamada Ryohei, Tazoe Hirofumi, Miura Tomisato, Akata Naofumi, Tsujiguchi Takakiyo, Ito Katsuhiro, Nakamura Toshiya, Tokonami Shinji, Kashiwakura Ikuo
Radiation Environment and Medicine 14 ( 2 ) 83 2025年08月
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Comparison of Surface Dose Increment Using Various Immobilization Devices in 6 MV X-Ray Radiotherapy
Nemoto Takeru, Saga Ryo, Obara Hideki, Komai Fumio, Aoki Masahiko, Hosokawa Yoichiro
Radiation Environment and Medicine 14 ( 1 ) 7 - 12 2025年02月
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Risk Assessment of Cataract Development in Radiotherapy for Patients with Brain Tumors and Head and Neck Cancer
Saga Ryo, Okabe Haruka, Obara Hideki, Komai Fumio, Osanai Minoru, Aoki Masahiko, Hosokawa Yoichiro
Radiation Environment and Medicine 13 ( 2 ) 45 - 51 2024年08月
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Risk Assessment of Cataract Development in Radiotherapy for Patients with Brain Tumors and Head and Neck Cancer
Ryo Saga, Haruka Okabe, Hideki Obara, Fumio Komai, Minoru Osanai, Masahiko Aoki, Yoichiro Hosokawa
Radiation Environment and Medicine 13 ( 2 ) 45 - 51 2024年08月
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Generality assessment of a model considering heterogeneous cancer cells for predicting tumor control probability for stereotactic body radiotherapy against non-small cell lung cancer
Ryo Saga, Yusuke Matsuya, Hideki Obara, Fumio Komai, Hironori Yoshino, Masahiko Aoki, Yoichiro Hosokawa
Advances in Radiation Oncology 101437 - 101437 2024年01月
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Are Online Simulations for Radiation Emergency Medical Preparedness Less Effective in Teaching Than Face-to-Face Simulations?
Tomisawa T, Hosokawa S, Kudo H, Osanai M, Ota K, In N, Ohgino A, Tsujiguchi T, Takamagi S, Tsuchiya R, Kitajima M, Terashima S, Yamaguchi M, Saga R, Mikami K, Urushizaka M, Sakai M, Aizu K, Hosokawa Y, Hanada H
Disaster medicine and public health preparedness 17 e520 2023年10月
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Fundamental evaluation of dose and dose distribution under applied topical agents and dressings used for skin care in radiotherapy
Hikari Sato, Ryo Saga, Fumio Komai, Yumiko Sato, Hideki Obara, Masahiko Aoki, Yoichiro Hosokawa
Journal of Radiation Research and Applied Sciences 16 ( 3 ) 2023年09月
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Biophysical Simulations for Estimating Biological Effects after Exposure to Ionizing Radiation: Current State and Future Prospects
Matsuya Yusuke, Saga Ryo
Radiation Environment and Medicine 12 ( 2 ) 81 - 90 2023年08月
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Translational study for stereotactic body radiotherapy against non-small cell lung cancer, including oligometastases, considering cancer stem-like cells enable predicting clinical outcome from in vitro data.
Saga R, Matsuya Y, Sato H, Hasegawa K, Obara H, Komai F, Yoshino H, Aoki M, Hosokawa Y
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 181 109444 - 109444 2023年04月
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Modelling oxygen effects on the in- and out-of-field radiosensitivity of cells exposed to intensity-modulated radiation fields.
Matsuya Y, McMahon SJ, Butterworth KT, Yachi Y, Saga R, Sato T, Prise KM
Physics in medicine and biology 68 ( 9 ) 2023年03月
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Radiotherapeutic Review: Acquisition of Radioresistance and Cancer Stem Cell Properties via Irradiation
Hasegawa* Kazuki, Saga Ryo, Hosokawa Yoichiro
Radiation Environment and Medicine 12 ( 1 ) 25 - 36 2023年02月
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DNA‑PKcs phosphorylation specific inhibitor, NU7441, enhances the radiosensitivity of clinically relevant radioresistant oral squamous cell carcinoma cells.
Ohuchi K, Saga R, Hasegawa K, Tsuruga E, Hosokawa Y, Fukumoto M, Okumura K
Biomedical reports 18 ( 4 ) 28 - 28 2023年02月
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4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression
嵯峨 涼, 桑原 義和, 富田 和男, 佐藤 友昭, 福本 学, 細川 洋一郎
Cells 11 ( 23 ) 3780 - 3780 2022年11月
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癌の放射線抵抗性と幹細胞特性の獲得および数理モデルによる複合的アプローチ
嵯峨涼、長谷川和輝、細川洋一郎
放射線生物研究 57 ( 2 ) 132 - 151 2022年07月
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Training of Medical Responders to Nuclear Disaster: Hybrid Program in the COVID-19 Pandemic
Toshiko Tomisawa, Naoya In, Kazuki Ota, Takakiyo Tsujiguchi, Hiromi Kudo, Minoru Osanai, Kasumi Mikami, Shota Hosokawa, Shingo Terashima, Maiko Kitajima, Ryo Saga, Masaru Yamaguchi, Ryoko Tsuchiya, Mayumi Urushizaka, Yoichiro Hosokawa, Hiroyuki Hanada
Disaster Medicine and Public Health Preparedness 4 1 - 12 2022年03月
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Identification of novel prognostic factors focusing on clinical outcomes in patients with non-small cell lung cancer after stereotactic body radiotherapy.
Sato H, Ito F, Hasegawa K, Saga R, Hosokawa Y, Tanaka M, Aoki M
Oncology letters 23 ( 3 ) 79 - 79 2022年03月
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Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability.
Fukui R, Saga R, Matsuya Y, Tomita K, Kuwahara Y, Ohuchi K, Sato T, Okumura K, Date H, Fukumoto M, Hosokawa Y
Scientific reports 12 ( 1 ) 1056 2022年01月
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4-Methylumbelliferone administration enhances radiosensitivity of human fibrosarcoma by intercellular communication.
Saga R, Matsuya Y, Takahashi R, Hasegawa K, Date H, Hosokawa Y
Scientific reports 11 ( 1 ) 8258 2021年12月
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The Clinical Usefulness of Water/Iodine Material Density Measured by DE-CT
Hasegawa Kazuki, Saga Ryo, Sato Yuta, Tanaka Mitsuki, Katagishi Ryo, Aoki Masahiko, Hosokawa Yoichiro
Radiation Environment and Medicine 10 ( 2 ) 82 - 86 2021年08月
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Radiation Safety and Public Health for Radiological Professionals: Meeting Report on The 5th Educational Symposium on Radiation and Health (ESRAH) by Young Scientists in 2018
Hiroko Yamashina, Marin Terashima, Joma Oikawa, Shingo Naijo, Tamao Miyao, Yoshie Yachi, Yusuke Matsuya, Masaru Yamaguchi, Takakiyo Tsujiguchi, Ryo Saga, Hu Jun, Goh Valerie Swee Ting, Toshiya Nakamura, Yoichiro Hosokawa, Hiroyuki Date
Radiation Environment and Medicine 10 ( 1 ) 48 - 54 2021年06月
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Oxygen enhancement ratios of cancer cells after exposure to intensity modulated x-ray fields: DNA damage and cell survival.
Matsuya Y, McMahon SJ, Butterworth KT, Naijo S, Nara I, Yachi Y, Saga R, Ishikawa M, Sato T, Date H, Prise KM
Physics in medicine and biology 66 ( 7 ) 075014 - 075014 2021年04月
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Matrix Metalloproteinase-2 Activated by Ultraviolet-B Degrades Human Ciliary Zonules <i>In Vitro</i>.
Shiroto Y, Saga R, Yoshino H, Hosokawa Y, Isokawa K, Tsuruga E
Ａｃｔａ Ｈｉｓｔｏｃｈｅｍｉｃａ ｅｔ Ｃｙｔｏｃｈｅｍｉｃａ 54 ( 1 ) 1 - 9 2021年02月
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The clinical usefulness of Water/Iodine material density measured by DE-CT
Kazuki Hasegawa, Ryo Saga, Yuta Sato, Mitsuki Tanaka, Ryo Katagishi, Masahiko Aoki, Yoichiro Hosokawa
Radiation Environment and Medicine 10 ( 2 ) 2021年
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Radiation Safety and Public Health for Radiological Professionals : Meeting Report on The 5th Educational Symposium on Radiation and Health (ESRAH) by Young Scientists in 2018
Radiation Environment and Medicine 10 ( 1 ) 48 - 54 2021年
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4-methylumbelliferone inhibits clonogenic potency by suppressing high molecular weight-hyaluronan in fibrosarcoma cells.
Hasegawa K, Saga R, Takahashi R, Fukui R, Chiba M, Okumura K, Tsuruga E, Hosokawa Y
Oncology letters 19 ( 4 ) 2801 - 2808 2020年04月
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放射線治療に関わる癌幹細胞
細川洋一郎、嵯峨涼、長谷川和輝、大内健太郎、奥村一彦
保健科学研究 10 ( 2 ) 2020年03月
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4-methylumbelliferone inhibits clonogenic potency by suppressing high molecular weight-hyaluronan in fibrosarcoma cells
Kazuki Hasegawa, Ryo Saga, Rei Takahashi, Roman Fukui, Mitsuru Chiba, Kazuhiko Okumura, Eichi Tsuruga, Yoichiro Hosokawa
Oncology Letters 2020年02月
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X線照射がラット肺胞線維芽細胞のエラスチンへ及ぼす影響
北山義尚, 白戸佑貴, 椎谷賢, 嵯峨涼, 寺島真悟, 細川洋一郎, 敦賀英知
保健科学研究 10 ( 1 ) 19 - 24 2019年09月
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Apoptotic Induction Mechanism of X-ray Irradiation Combined with Hydrogen Peroxide
Fujita Satoshi, Hosokawa Yoichiro, Saga Ryo, Tsuruga Eichi, Okumura Kazuhiko, Ohuchi Kentaro, Ochi Morio
Radiation Environment and Medicine 8 ( 2 ) 85 - 93 2019年09月
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Understanding the mechanism underlying the acquisition of radioresistance in human prostate cancer cells.
Murata K, Saga R, Monzen S, Tsuruga E, Hasegawa K, Hosokawa Y
Oncology letters 17 ( 6 ) 5830 - 5838 2019年06月
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Analysis of the high-dose-range radioresistance of prostate cancer cells, including cancer stem cells, based on a stochastic model.
Saga R, Matsuya Y, Takahashi R, Hasegawa K, Date H, Hosokawa Y
Journal of radiation research 60 ( 3 ) 298 - 307 2019年05月
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Regulation of radiosensitivity by 4-methylumbelliferone via the suppression of interleukin-1 in fibrosarcoma cells
RYO SAGA, KAZUKI HASEGAWA, KOSHO MURATA, MITSURU CHIBA, TOSHIYA NAKAMURA, KAZUHIKO OKUMURA, EICHI TSURUGA and YOICHIRO HOSOKAWA
Oncology Letters 17 ( 3 ) 3555 - 3561 2019年02月
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Radio-resistance analysis in high-dose range of prostate cancer cells including cancer stem cells based on a stochastic model
Ryo Saga, Yusuke Matsuya, Rei Takahashi, Kazuki Hasegawa, Hiroyuki Date, Yoichiro Hosokawa
Journal of Radiation Research 2019 1 - 10 2019年
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Meeting Report on "The 4th Educational Symposium on Radiation and Health (ESRAH) by Young Scientists in 2017"
Saga Ryo, Tsujiguchi Takakiyo, Yamaguchi Masaru, Fukushi Yasuyo, Fujishima Yohei, Matsuya Yusuke, Oikawa Joma, Terashima Marin, Date Hiroyuki, Nakamura Toshiya, Hosokawa Yoichiro
Radiation environment and medicine : covering a broad scope of topics relevant to environmental and medical radiation research 7 ( 2 ) 121 - 124 2018年08月
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Educational Activity for the Radiation Emergency System in the Northern Part of Japan: Meeting Report on "The 3rd Educational Symposium on Radiation and Health (ESRAH) by Young Scientists in 2016".
Matsuya Y, Tsujiguchi T, Yamaguchi M, Kimura T, Mori R, Yamada R, Saga R, Fujishima Y, Date H
Radiation research 187 ( 6 ) 641 - 646 2017年06月
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Anti-tumor and anti-invasion effects of a combination of 4-methylumbelliferone and ionizing radiation in human fibrosarcoma cells.
Ryo Saga, Satoru Monzen, Mitsuru Chiba, Hironori Yoshino, Toshiya Nakamura, Yoichiro Hosokawa
Oncology letters 13 ( 1 ) 410 - 416 2017年01月
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Ascorbic acid does not reduce the anticancer effect of radiotherapy.
Hosokawa Y, Saga R, Monzen S, Terashima S, Tsuruga E
Biomedical reports 6 ( 1 ) 103 - 107 2017年01月
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Report on Radiation Emergency Medicine Education and Training Course
Ryo Saga, Yoichiro Hosokawa, Yoko Saito, Chieko Itaki, Toshiya Nakamura
Radiation Environment and Medicine 5 ( 2 ) 50 - 55 2016年08月
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Investigation of γ-ray Dose Rate in Air at Densely-inhabited District in Fukushima Prefecture
Yosuke Suzuki, Takuya Harada, Yuriko Moro, Wakana Hozumi, Yoshitaka Shiroma, Ryo Saga, Yoichiro Hosokawa
Radiation Environment and Medicine 5 ( 2 ) 33 - 38 2016年08月
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Effects of X‑ray irradiation in combination with ascorbic acid on tumor control.
Hosokawa Y, Monzen S, Yoshino H, Terashima S, Nakano M, Toshima K, Saga R, Kashiwakura I
Molecular medicine reports 12 ( 4 ) 5449 - 54 2015年10月