Society for Neuroscience

日本神経精神薬理学会

日本薬理学会

Anthocyanin-rich blackcurrant extract improves long-term memory impairment and emotional abnormality in senescence-accelerated mice.

Shimada M, Maeda H, Nanashima N, Yamada K, Nakajima A.

J Food Biochem.   2022.10

A Narrative Review of the Effects of Citrus Peels and Extracts on Human Brain Health and Metabolism.

Matsuzaki K, Nakajima A, Guo Y, Ohizumi Y.

Nutrients.   2022.4

Isolation of adenosine and cordysinin B from Anredera cordifolia that stimulates CRE-mediated transcription in PC12 cells

Ohizumi Y, Kawada M, Kamada M, Nakajima A, Kajima K, Uozumi N, Hara Y, Guo Y, Ishibashi M

Planta Medica International Open   2021.3

An evaluation of the genotoxicity and subchronic toxicity of the peel extract of Ponkan cultivar 'Ohta ponkan' (Citrus reticulata Blanco) that is rich in nobiletin and tangeretin with anti-dementia activity

Nakajima A, Nemoto K, Ohizumi Y

Regul Toxicol Pharmacol.   114   104670   2020.7

Potential benefits of nobiletin, a citrus flavonoid, against Alzheimer’s disease and Parkinson’s disease.

Nakajima A, Ohizumi Y

Int J Mol Sci.   E3380   2019.7

Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3.

Yamada S, Itoh N, Nagai T, Nakai T, Ibi D, Nakajima A, Nabeshima T, Yamada K

J Neuroinflammation.   15   295   2018.10

Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes.

Sobue A, Ito N, Nagai T, Shan W, Hada K, Nakajima A, Murakami Y, Mouri A, Yamamoto Y, Nabeshima T, Saito K, Yamada K

Glia.   66   1034 - 1052   2018.5

Fluoroquinolones and propionic acid derivatives induce inflammatory responses in vitro.

Nakajima A, Sato H, Oda S, Yokoi T

Cell Biol Toxicol.   34   65 - 77   2018

A novel cell-based assay for the evaluation of immune- and inflammatory-related gene expression as biomarkers for the risk assessment of drug-induced liver injury.

Oda S, Matsuo K, Nakajima A, Yokoi T

Toxicol Lett.   241   60 - 70   2016

Allopurinol induces innate immune responses through mitogen-activated protein kinase signaling pathways in HL-60 cells.

Nakajima A, Oda S, Yokoi T

J Appl Toxicol.   36   1120 - 1128   2016

Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injury in mice.

Oda S, Shirai Y, Akai S, Nakajima A, Tsuneyama K, Yokoi T

J Appl Toxicol.   37   545 - 553   2016

Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer’s disease (3XTg-AD).

Nakajima A, Aoyama Y, Shin EJ, Nam Y, Kim HC, Nagai T, Yokosuka A, Mimaki Y, Yokoi T, Ohizumi Y, Yamada K

Behav Brain Res.   269   69 - 77   2015

Induction of interferon-induced transmembrane protein 3 gene expression by lipopolysaccharide in astrocytes.

Nakajima A, Ibi D, Nagai T, Yamada S, Nabeshima T, Yamada K

Eur J Pharmacol.   2014

Expression of the G72/G30 gene in transgenic mice induces behavioral changes.

Cheng L, Hattori E, Nakajima A, Woehrle NS, Opal MD, Zhang C, Grennan K, Dulawa SC, Tang YP, Gershon ES, Liu C

Mol Psychiatry.   19   175 - 183   2014

Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes.

Yamada S, Nagai T, Nakai T, Ibi D, Nakajima A, Yamada K

Brain Behav Immun.   38   272 - 282   2014

SLC10A4 is a protease-activated transporter that transports bile acids.

Abe T, Kanemitu Y, Nakasone M, Kawahata I, Yamakuni T, Nakajima A, Suzuki N, Nishikawa M, Hishinuma T, Tomioka Y

J Biochem.   154   93 - 101   2013

Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.

Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, Kano SI, Sato Y, Hayakawa M, Lange UC, Adams DJ, Surani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T, Yamada K

Glia.   61   679 - 693   2013

Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action.

Kawahata I, Yoshida M, Sun W, Nakajima A, Lai Y, Osaka N, Matsuzaki K, Yokosuka A, Mimaki Y, Naganuma A, Tomioka Y, Yamakuni T

J Neural Transm.   120   1397 - 1409   2013

Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse.

Nakajima A, Aoyama Y, Nguyen TY, Shin EJ, Kim HC, Yamada S, Nakai T, Nagai T, Yokosuka A, Mimaki Y, Ohizumi Y, Yamada K

Behav Brain Res.   250   351 - 360   2013

Repeated treatment with nicotine induces phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization.

Nakajima A, Kinugasa Y, Torii J, Hishinuma T, Tomioka Y, Yamada K, Yamakuni T

Neurosci Lett.   524   133 - 138   2012

Post-training dephosphorylation of eEF-2 promotes protein synthesis for memory consolidation.

Im HI, Nakajima A, Gong B, Xiong X, Mamiya T, Gershon ES, Zhuo M, Tang YP

PLoS ONE.   13   e7424   2009

Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.

Yamamoto Y, Shioda N, Han F, Moriguchi S, Nakajima A, Yokosuka A, Mimaki Y, Sashida Y, Yamakuni T, Ohizumi Y, Fukunaga K

Brain Res.   1295   218 - 229   2009

4´-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor-antagonism via stimulation of ERK cascade.

Rahim Md Al, Nakajima A, Saigusa D, Tetsu N, Maruyama Y, Shibuya M, Yamakoshi H, Tomioka Y, Iwabuchi Y, Ohizumi Y, Yamakuni T

Biochemistry.   18   7713 - 7721   2009

Neurobehavioral effects of tetrabromobisphenol A, a brominated flame retardant, in mice.

Nakajima A, Saigusa D, Tetsu N, Yamakuni T, Tomioka Y, Hishinuma T

Toxicol Lett.   189   78 - 83   2009

A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Aβ-inhibition of the cascade in cultured rat CNS neurons.

Rahim Md Al, Nakajima A, Misawa N, Shindo K, Adachi K, Shizuri Y, Ohizumi Y, Yamakuni T

Eur J Pharmacol.   600   10 - 17   2008

Adult neurogenesis is functionally associated with AD-like neurodegeneration.

Chen Q, Nakajima A, Choi SH, Xiong X, Sisodia SS, Tang YP

Neurobiol Dis.   29   316 - 326   2008

Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse.

Chen Q, Nakajima A, Choi SH, Xiong X, Tang YP

J Neurosci Res.   86   1615 - 1625   2008

Expression of NR2B in Cerebellar Granule Cells Specifically Facilitates Effect of Motor Training on Motor Learning.

Jiao J, Nakajima A, Janssen WG, Bindokas VP, Xiong X, Morrison JH, Brorson JR, Tang YP

PLoS ONE.   3 ( e1684 )   1 - 11   2008

Nobiletin, a citrus flavonoid, improves memory impairment and Aβ pathology in a transgenic mouse model of Alzheimer’s disease.

Onozuka H, Nakajima A, Matsuzaki K, Shin RW, Ogino K, Saigusa D, Tetsu N, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y

J Pharmacol Exp Ther.   326   739 - 744   2008

Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.

Nakajima A, Yamakuni T, Haraguchi M, Omae N, Song SY, Kato C, Tadano T, Yokosuka A, Mimaki Y, Sashida Y, Ohizumi Y

J Pharmacol Sci.   105   122 - 126   2007

An inducer for glial cell line-derived neurotrophic factor and tumor necrosis factor-alpha protects against methamphetamine-induced rewarding effects and sensitization.

Niwa M, Nitta A, Yamada Y, Nakajima A, Saito K, Seishima M, Shen L, Noda Y, Furukawa S, Nabeshima T

Biol Psychiatry.   61   890 - 901   2007

TNF-alpha and its inducer inhibit morphine-induced rewarding effects and sensitization.

Niwa M, Nitta A, Yamada Y, Nakajima A, Saito K, Seishima M, Noda Y, Nabeshima T

Biol Psychiatry.   62   658 - 668   2007

Nobiletin, a citrus flavonoid, reverses learning impairment associated with NMDA receptor antagonism by activation of ERK signaling.

Nakajima A, Yamakuni T, Matsuzaki K, Nakata N, Onozuka H, Yokosuka A, Sashida Y, Mimaki Y, Ohizumi Y

J Pharmacol Exp Ther.   321   784 - 790   2007

Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds.

Yan Y, Nitta A, Mizuno T, Nakajima A, Yamada K, Nabeshima T

Behav Brain Res.   173   39 - 46   2006

Elevated cholecystokininergic tone constitutes an important molecular/neuronal mechanism for the expression of anxiety in the mouse.

Chen Q, Nakajima A, Meacham C, Tang YP

Proc Natl Acad Sci USA.   103   3881 - 3886   2006

Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity.

Nakajima A, Yamada K, Nagai T, Uchiyama T, Miyamoto Y, Mamiya T, He J, Nitta A, Mizuno M, Tran MH, Seto A, Yoshimura M, Kitaichi K, Hasegawa T, Saito K, Yamada Y, Seishima M, Sekikawa K, Kim HC, Nabeshima T

J Neurosci.   24   2212 - 2225   2004

Anatomical substrates for the discriminative stimulus effects of methamphetamine in rats.

Nakajima A, Yamada K, He J, Zeng N, Nitta A, Nabeshima T

J Neurochem.   91   308 - 317   2004

Immunocytochemical evidence that amyloid β (1-42) impairs endogenous antioxidant systems in vivo.

Kim HC, Yamada K, Nitta A, Olariu A, Tran MH, Mizuno M, Nakajima A, Nagai T, Kamei H, Jhoo WK, Im DH, Shin EJ, Hjelle OP, Ottersen OP, Park SC. Kato K, Mirault ME, Nabeshima T

Neuroscience.   119   399 - 419   2003

Tyrosine nitration of a synaptic protein synaptophysin contibutes to amyloid-peptide-induced cholinergic dysfunction.

Tran MH, Yamada K, Nakajima A, Mizuno M, He J, Kamei H, Nabeshima T

Mol Psychiatry.   8   407 - 412   2003

Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation.

Mizuno M, Yamada K, Takei N, Tran MH, He J, Nakajima A, Nawa H, Nabeshima T

Mol Psychiatry.   8   217 - 224   2003

Involvement of BDNF receptor TrkB in spatial memory formation.

Mizuno M, Yamada K, He J, Nakajima A, Nabeshima T

Learn Mem.   10   108 - 115   2003

Interleukin-6 protects PC12 cells from 4-hydroxynonenal-induced cytotoxicity by increasing intracellular glutathione levels.

Nakajima A, Yamada K, Zou L,B, Yan Y, Mizuno M, Nabeshima T

Free Radic Biol Med.   32   1324 - 1332   2002

Learning and memory in two different reward tasks in a radial arm maze in rats.

He J, Yamada K, Nakajima A, Kamei H, Nabeshima T

Behav Brain Res.   134   139 - 148   2002

Phencyclidine-induced discriminative stimulus is mediated via phencyclidine binding sites on the N-methyl-D-aspartate receptor-ion channel complex, not via sigma1 receptors.

Mori A., Noda Y, Mamiya T, Miyamoto Y, Nakajima A, Furukawa H, Nabeshima T

Behav Brain Res.   119   33 - 40   2001