Papers - NAKAJIMA Akira
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Structure, anti-cancer properties, and potential mechanism of a biological active polysaccharide from Platycodon grandiflorum.
Liu W, Zhang J, Li Y, Nakajima A, Lee D, Xu J, Guo Y.
Int J Biol Macromol. 2024.10
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Apple Pomace Extract Induces Cell Proliferation and Increases Type I Collagen and Hyaluronan Production in Human Skin Fibroblasts In Vitro.
Nanashima N, Maeda H, Nakajima A, Nishizuka M, Narumi T, Ichita J, Itoku K.
Plant Foods Hum Nutr. 2024.9
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A fungal polysaccharide from Fomitopsis officinalis as a multi-target molecule to combat cancer.
Liu W, Shen Y, Hou J, Jiang H, Wang Q, Zhang L, Nakajima A, Lee D, Xu J, Guo Y.
Int J Biol Macromol. 2024.6
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Apple Pomace Extract Improves MK-801-Induced Memory Impairment in Mice.
Watanabe A, Shimada M, Maeda H, Narumi T, Ichita J, Itoku K, Nakajima A.
Nutrients. 2024.1
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Iridoids from Patrinia heterophylla and their anti-inflammatory activity.
Liu W, Wu P, Song Z, Nie F, Zhang L, Lee D, Nakajima A, Xu J, Guo Y.
Phytochemistry. 2023.8
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A polysaccharide from Inula japonica showing in vivo antitumor activity by interacting with TLR-4, PD-1, and VEGF.
Wang X, Li Y, Liu W, Shen Y, Lin Z, Nakajima A, Xu J, Guo Y.
Int J Biol Macromol. 2023.8
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Tetrabromobisphenol A and hexabromocyclododecane, brominated flame retardants, trigger endoplasmic reticulum stress and activate necroptosis signaling in PC12 cells.
Abe N, Sasaki M, Nakajima A.
Environ Toxicol Pharmacol. 2023.3
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Structure, anti-tumor activity, and potential anti-tumor mechanism of a fungus polysaccharide from Fomes officinalis.
Zhang S, Li Y, Li Z, Liu W, Zhang H, Ohizumi Y, Nakajima A, Xu J, Guo Y.
Carbohydr Polym. 2022.11
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Anthocyanin-rich blackcurrant extract improves long-term memory impairment and emotional abnormality in senescence-accelerated mice.
Shimada M, Maeda H, Nanashima N, Yamada K, Nakajima A.
J Food Biochem. 2022.10
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A Narrative Review of the Effects of Citrus Peels and Extracts on Human Brain Health and Metabolism.
Matsuzaki K, Nakajima A, Guo Y, Ohizumi Y.
Nutrients. 2022.4
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Isolation of adenosine and cordysinin B from Anredera cordifolia that stimulates CRE-mediated transcription in PC12 cells
Ohizumi Y, Kawada M, Kamada M, Nakajima A, Kajima K, Uozumi N, Hara Y, Guo Y, Ishibashi M
Planta Medica International Open 2021.3
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An evaluation of the genotoxicity and subchronic toxicity of the peel extract of Ponkan cultivar 'Ohta ponkan' (Citrus reticulata Blanco) that is rich in nobiletin and tangeretin with anti-dementia activity
Nakajima A, Nemoto K, Ohizumi Y
Regul Toxicol Pharmacol. 114 104670 2020.7
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Potential benefits of nobiletin, a citrus flavonoid, against Alzheimer’s disease and Parkinson’s disease.
Nakajima A, Ohizumi Y
Int J Mol Sci. E3380 2019.7
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Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3.
Yamada S, Itoh N, Nagai T, Nakai T, Ibi D, Nakajima A, Nabeshima T, Yamada K
J Neuroinflammation. 15 295 2018.10
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Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes.
Sobue A, Ito N, Nagai T, Shan W, Hada K, Nakajima A, Murakami Y, Mouri A, Yamamoto Y, Nabeshima T, Saito K, Yamada K
Glia. 66 1034 - 1052 2018.5
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Fluoroquinolones and propionic acid derivatives induce inflammatory responses in vitro.
Nakajima A, Sato H, Oda S, Yokoi T
Cell Biol Toxicol. 34 65 - 77 2018
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A novel cell-based assay for the evaluation of immune- and inflammatory-related gene expression as biomarkers for the risk assessment of drug-induced liver injury.
Oda S, Matsuo K, Nakajima A, Yokoi T
Toxicol Lett. 241 60 - 70 2016
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Allopurinol induces innate immune responses through mitogen-activated protein kinase signaling pathways in HL-60 cells.
Nakajima A, Oda S, Yokoi T
J Appl Toxicol. 36 1120 - 1128 2016
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Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injury in mice.
Oda S, Shirai Y, Akai S, Nakajima A, Tsuneyama K, Yokoi T
J Appl Toxicol. 37 545 - 553 2016
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Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer’s disease (3XTg-AD).
Nakajima A, Aoyama Y, Shin EJ, Nam Y, Kim HC, Nagai T, Yokosuka A, Mimaki Y, Yokoi T, Ohizumi Y, Yamada K
Behav Brain Res. 269 69 - 77 2015
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Expression of the G72/G30 gene in transgenic mice induces behavioral changes.
Cheng L, Hattori E, Nakajima A, Woehrle NS, Opal MD, Zhang C, Grennan K, Dulawa SC, Tang YP, Gershon ES, Liu C
Mol Psychiatry. 19 175 - 183 2014
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Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes.
Yamada S, Nagai T, Nakai T, Ibi D, Nakajima A, Yamada K
Brain Behav Immun. 38 272 - 282 2014
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Induction of interferon-induced transmembrane protein 3 gene expression by lipopolysaccharide in astrocytes.
Nakajima A, Ibi D, Nagai T, Yamada S, Nabeshima T, Yamada K
Eur J Pharmacol. 2014
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SLC10A4 is a protease-activated transporter that transports bile acids.
Abe T, Kanemitu Y, Nakasone M, Kawahata I, Yamakuni T, Nakajima A, Suzuki N, Nishikawa M, Hishinuma T, Tomioka Y
J Biochem. 154 93 - 101 2013
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Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.
Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, Kano SI, Sato Y, Hayakawa M, Lange UC, Adams DJ, Surani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T, Yamada K
Glia. 61 679 - 693 2013
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Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action.
Kawahata I, Yoshida M, Sun W, Nakajima A, Lai Y, Osaka N, Matsuzaki K, Yokosuka A, Mimaki Y, Naganuma A, Tomioka Y, Yamakuni T
J Neural Transm. 120 1397 - 1409 2013
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Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse.
Nakajima A, Aoyama Y, Nguyen TY, Shin EJ, Kim HC, Yamada S, Nakai T, Nagai T, Yokosuka A, Mimaki Y, Ohizumi Y, Yamada K
Behav Brain Res. 250 351 - 360 2013
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Repeated treatment with nicotine induces phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization.
Nakajima A, Kinugasa Y, Torii J, Hishinuma T, Tomioka Y, Yamada K, Yamakuni T
Neurosci Lett. 524 133 - 138 2012
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Post-training dephosphorylation of eEF-2 promotes protein synthesis for memory consolidation.
Im HI, Nakajima A, Gong B, Xiong X, Mamiya T, Gershon ES, Zhuo M, Tang YP
PLoS ONE. 13 e7424 2009
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Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.
Yamamoto Y, Shioda N, Han F, Moriguchi S, Nakajima A, Yokosuka A, Mimaki Y, Sashida Y, Yamakuni T, Ohizumi Y, Fukunaga K
Brain Res. 1295 218 - 229 2009
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4´-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor-antagonism via stimulation of ERK cascade.
Rahim Md Al, Nakajima A, Saigusa D, Tetsu N, Maruyama Y, Shibuya M, Yamakoshi H, Tomioka Y, Iwabuchi Y, Ohizumi Y, Yamakuni T
Biochemistry. 18 7713 - 7721 2009
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Neurobehavioral effects of tetrabromobisphenol A, a brominated flame retardant, in mice.
Nakajima A, Saigusa D, Tetsu N, Yamakuni T, Tomioka Y, Hishinuma T
Toxicol Lett. 189 78 - 83 2009
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Nobiletin, a citrus flavonoid, improves memory impairment and Aβ pathology in a transgenic mouse model of Alzheimer’s disease.
Onozuka H, Nakajima A, Matsuzaki K, Shin RW, Ogino K, Saigusa D, Tetsu N, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y
J Pharmacol Exp Ther. 326 739 - 744 2008
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A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Aβ-inhibition of the cascade in cultured rat CNS neurons.
Rahim Md Al, Nakajima A, Misawa N, Shindo K, Adachi K, Shizuri Y, Ohizumi Y, Yamakuni T
Eur J Pharmacol. 600 10 - 17 2008
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Expression of NR2B in Cerebellar Granule Cells Specifically Facilitates Effect of Motor Training on Motor Learning.
Jiao J, Nakajima A, Janssen WG, Bindokas VP, Xiong X, Morrison JH, Brorson JR, Tang YP
PLoS ONE. 3 ( e1684 ) 1 - 11 2008
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Adult neurogenesis is functionally associated with AD-like neurodegeneration.
Chen Q, Nakajima A, Choi SH, Xiong X, Sisodia SS, Tang YP
Neurobiol Dis. 29 316 - 326 2008
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Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse.
Chen Q, Nakajima A, Choi SH, Xiong X, Tang YP
J Neurosci Res. 86 1615 - 1625 2008
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Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.
Nakajima A, Yamakuni T, Haraguchi M, Omae N, Song SY, Kato C, Tadano T, Yokosuka A, Mimaki Y, Sashida Y, Ohizumi Y
J Pharmacol Sci. 105 122 - 126 2007
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An inducer for glial cell line-derived neurotrophic factor and tumor necrosis factor-alpha protects against methamphetamine-induced rewarding effects and sensitization.
Niwa M, Nitta A, Yamada Y, Nakajima A, Saito K, Seishima M, Shen L, Noda Y, Furukawa S, Nabeshima T
Biol Psychiatry. 61 890 - 901 2007
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TNF-alpha and its inducer inhibit morphine-induced rewarding effects and sensitization.
Niwa M, Nitta A, Yamada Y, Nakajima A, Saito K, Seishima M, Noda Y, Nabeshima T
Biol Psychiatry. 62 658 - 668 2007
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Nobiletin, a citrus flavonoid, reverses learning impairment associated with NMDA receptor antagonism by activation of ERK signaling.
Nakajima A, Yamakuni T, Matsuzaki K, Nakata N, Onozuka H, Yokosuka A, Sashida Y, Mimaki Y, Ohizumi Y
J Pharmacol Exp Ther. 321 784 - 790 2007
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Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds.
Yan Y, Nitta A, Mizuno T, Nakajima A, Yamada K, Nabeshima T
Behav Brain Res. 173 39 - 46 2006
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Elevated cholecystokininergic tone constitutes an important molecular/neuronal mechanism for the expression of anxiety in the mouse.
Chen Q, Nakajima A, Meacham C, Tang YP
Proc Natl Acad Sci USA. 103 3881 - 3886 2006
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Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity.
Nakajima A, Yamada K, Nagai T, Uchiyama T, Miyamoto Y, Mamiya T, He J, Nitta A, Mizuno M, Tran MH, Seto A, Yoshimura M, Kitaichi K, Hasegawa T, Saito K, Yamada Y, Seishima M, Sekikawa K, Kim HC, Nabeshima T
J Neurosci. 24 2212 - 2225 2004
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Anatomical substrates for the discriminative stimulus effects of methamphetamine in rats.
Nakajima A, Yamada K, He J, Zeng N, Nitta A, Nabeshima T
J Neurochem. 91 308 - 317 2004
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Immunocytochemical evidence that amyloid β (1-42) impairs endogenous antioxidant systems in vivo.
Kim HC, Yamada K, Nitta A, Olariu A, Tran MH, Mizuno M, Nakajima A, Nagai T, Kamei H, Jhoo WK, Im DH, Shin EJ, Hjelle OP, Ottersen OP, Park SC. Kato K, Mirault ME, Nabeshima T
Neuroscience. 119 399 - 419 2003
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Tyrosine nitration of a synaptic protein synaptophysin contibutes to amyloid-peptide-induced cholinergic dysfunction.
Tran MH, Yamada K, Nakajima A, Mizuno M, He J, Kamei H, Nabeshima T
Mol Psychiatry. 8 407 - 412 2003
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Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation.
Mizuno M, Yamada K, Takei N, Tran MH, He J, Nakajima A, Nawa H, Nabeshima T
Mol Psychiatry. 8 217 - 224 2003
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Involvement of BDNF receptor TrkB in spatial memory formation.
Mizuno M, Yamada K, He J, Nakajima A, Nabeshima T
Learn Mem. 10 108 - 115 2003
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Interleukin-6 protects PC12 cells from 4-hydroxynonenal-induced cytotoxicity by increasing intracellular glutathione levels.
Nakajima A, Yamada K, Zou L,B, Yan Y, Mizuno M, Nabeshima T
Free Radic Biol Med. 32 1324 - 1332 2002
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Learning and memory in two different reward tasks in a radial arm maze in rats.
He J, Yamada K, Nakajima A, Kamei H, Nabeshima T
Behav Brain Res. 134 139 - 148 2002
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Phencyclidine-induced discriminative stimulus is mediated via phencyclidine binding sites on the N-methyl-D-aspartate receptor-ion channel complex, not via sigma1 receptors.
Mori A., Noda Y, Mamiya T, Miyamoto Y, Nakajima A, Furukawa H, Nabeshima T
Behav Brain Res. 119 33 - 40 2001