Updated on 2023/02/06

写真a

 
FUJII Hodaka
 
Affiliation
Graduate School of Medicine Medical Science Course Biochemistry and Genome Biology
Contact information
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Degree

  • 博士(医学)

Research Interests

  • chromatin

  • Epigenetics

  • molecular biology

  • biochemistry

Research Areas

  • Life Science / Medical biochemistry

  • Life Science / Molecular biology

Professional Memberships

  • American Association for Cancer Research (AACR)

  • Japanese Cancer Association

  • 日本エピジェネティクス研究会

  • American Society for Biochemistry and Molecular Biology (ASBMB)

  • The American Association of Immunologists (AAI)

  • 日本分子生物学会

  • Japanese Society of Immunology

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Papers

  • Identification of telomere-associated molecules by engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP)

    Toshitsugu Fujita, Yoshinori Asano, Junko Ohtsuka, Yoko Takada, Kazunobu Saito, Rieko Ohki, Hodaka Fujii

    SCIENTIFIC REPORTS   3   3171   2013.11

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  • Efficient isolation of specific genomic regions and identification of associated proteins by engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP) using CRISPR

    Toshitsugu Fujita, Hodaka Fujii

    Biochemical and Biophysical Research Communications   439 ( 1 )   132 - 136   2013.9

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  • Direct Identification of Insulator Components by Insertional Chromatin Immunoprecipitation

    Toshitsugu Fujita, Hodaka Fujii

    PLOS ONE   6 ( 10 )   e26109   2011.10

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  • Insertional chromatin immunoprecipitation: A method for isolating specific genomic regions

    Akemi Hoshino, Hodaka Fujii

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   108 ( 5 )   446 - 449   2009.11

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  • Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase

    Akemi Hoshino, John A. Hirst, Hodaka Fujii

    JOURNAL OF BIOLOGICAL CHEMISTRY   282 ( 24 )   17706 - 17711   2007.6

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  • Development of transgenic mice overexpressing mouse carbonyl reductase 1

    Yokoyama M, Fujita T, Kadonosawa Y, Tatara Y, Motooka D, Ikawa M, Fujii H, Yokoayama Y

    Molecular Biology Reports   2022.11

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  • An enChIP system for the analysis of genome functions in budding yeast

    Fujii H, Fujita T

    Biology Methods & Protocols   7 ( 1 )   bpac025   2022.10

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  • Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma

    Imanishi S, Nagata S, Fujita T, Fujii H

    International Journal of Experimental Pathology   103 ( 6 )   245 - 251   2022.9

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  • IL-3-induced immediate expression of c-fos and c-jun is modulated by the IKK2-JNK axis

    Fujita H, Fujita T, Fujii H

    Cells   11 ( 9 )   1451   2022.4

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  • enChIP-Seq analyzer: a software program to analyze and interpret enChIP-Seq data for the detection of physical interactions between genomic regions

    Sarudate A, Fujita T, Nakayama T, Fujii H

    Genes   13   472   2022.3

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  • A stem cell marker KLF5 regulates CCAT1 via three-dimensional genome structure in colorectal cancer cells.

    Takashi Takeda, Yuhki Yokoyama, Hidekazu Takahashi, Daisuke Okuzaki, Kaho Asai, Hiroaki Itakura, Norikatsu Miyoshi, Shogo Kobayashi, Mamoru Uemura, Toshitsugu Fujita, Hiroo Ueno, Masaki Mori, Yuichiro Doki, Hodaka Fujii, Hidetoshi Eguchi, Hirofumi Yamamoto

    British journal of cancer   126   109 - 119   2021.10

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  • Protein or ribonucleoprotein-mediated blocking of recombinase polymerase amplification enables the discrimination of nucleotide and epigenetic differences between cell populations.

    Toshitsugu Fujita, Shoko Nagata, Hodaka Fujii

    Communications biology   4 ( 1 )   988 - 988   2021.8

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  • Corrigendum to "Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction" [Biochem. Biophys. Res. Commun. 354 (3) (2007) 825-829].

    Fujii H

    Biochemical and Biophysical Research Communications   552   196   2021.5

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  • Sequence-specific inhibition of reverse transcription by recombinant CRISPR/dCas13a ribonucleoprotein complexes in vitro

    Toshitsugu Fujita, Shoko Nagata, Miyuki Yuno, Hodaka Fujii

    Biology Methods and Protocols   6 ( 1 )   bpab009   2021.1

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  • MSCV-based retroviral plasmids expressing 3xFLAG-Sp-dCas9 for enChIP analysis.

    Miyuki Yuno, Shoko Nagata, Toshitsugu Fujita, Hodaka Fujii

    Biology methods & protocols   6 ( 1 )   bpab013   2021

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  • pSIR-bsr, a self-inactivating retrovirus vector expressing the blasticidin S-resistance gene.

    Fujii H

    Biology Methods & Protocols   6 ( 1 )   bpab022   2021

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  • SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination.

    Afzal Husain, Jianliang Xu, Hodaka Fujii, Mikiyo Nakata, Maki Kobayashi, Ji-Yang Wang, Jan Rehwinkel, Tasuku Honjo, Nasim A Begum

    EMBO Journal   39 ( 15 )   e102931 - e102931   2020.8

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  • Discrimination of CpG Methylation Status and Nucleotide Differences in Tissue Specimen DNA by Oligoribonucleotide Interference-PCR.

    Takeshi Shimizu, Toshitsugu Fujita, Sakie Fukushi, Yuri Horino, Hodaka Fujii

    International Journal of Molecular Sciences   21 ( 14 )   2020.7

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  • A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T reg cells

    Rabab Nasrallah, Charlotte J Imianowski, Lara Bossini-Castillo, Francis M Grant, Mikail Dogan, Lindsey Placek, Lina Kozhaya, Paula Kuo, Firas Sadiyah, Sarah K Whiteside, Maxwell R Mumbach, Dafni Glinos, Panagiota Vardaka, Carly E Whyte, Teresa Lozano, Toshitsugu Fujita, Hodaka Fujii, Adrian Liston, Simon Andrews, Adeline Cozzani, Jie Yang, Suman Mitra, Enrico Lugli, Howard Y Chang, Derya Unutmaz, Gosia Trynka, Rahul Roychoudhuri

    Nature   583 ( 7816 )   447 - 452   2020.6

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  • Simultaneous detection of the T790M and L858R mutations in the EGFR gene by oligoribonucleotide interference-PCR

    FUJII Hodaka

    International Journal of Molecular Sciences   20 ( 16 )   4020   2019.8

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  • Target enrichment from a DNA mixture by oligoribonucleotide interference-PCR (ORNi-PCR)

    FUJII Hodaka

    Biology Methods & Protocols   4 ( 1 )   bpz009   2019.8

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  • Normal B cell development and Pax5 expression in Thy28/ThyN1-deficient mice

    FUJII Hodaka

    PLoS One   14 ( 7 )   e0220199 - e0220199   2019.7

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  • A refined two-step oligoribonucleotide interference-PCR method for precise discrimination of nucleotide differences

    FUJII Hodaka

    Scientific Reports   8 ( 1 )   17195 - 17195   2018.11

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  • Detection of genome-edited cells by oligoribonucleotide interference-PCR.

    Fujita T, Yuno M, Kitaura F, Fujii H

    DNA research : an international journal for rapid publication of reports on genes and genomes   25 ( 4 )   395 - 407   2018.8

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  • An enChIP system for the analysis of bacterial genome functions

    Toshitsugu Fujita, Miyuki Yuno, Hodaka Fujii

    BMC Research Notes   11 ( 1 )   387 - 387   2018.6

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  • Promoter-associated proteins of EPAS1 identified by enChIP-MS – A putative role of HDX as a negative regulator

    Arash Hamidian, Marica Vaapil, Kristoffer von Stedingk, Toshitsugu Fujita, Camilla U. Persson, Pontus Eriksson, Srinivas Veerla, Katleen De Preter, Frank Speleman, Hodaka Fujii, Sven Påhlman, Sofie Mohlin

    Biochemical and Biophysical Research Communications   499 ( 2 )   291 - 298   2018.5

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  • EnChIP systems using different CRISPR orthologues and epitope tags

    Toshitsugu Fujita, Miyuki Yuno, Hodaka Fujii

    BMC Research Notes   11 ( 1 )   154 - 154   2018.2

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  • Transgenic mouse lines expressing the 3xFLAG-dCas9 protein for enChIP analysis

    Toshitsugu Fujita, Fusako Kitaura, Asami Oji, Naoki Tanigawa, Miyuki Yuno, Masahito Ikawa, Ichiro Taniuchi, Hodaka Fujii

    Genes to Cells   23 ( 4 )   318 - 325   2018.2

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  • Locus-specific ChIP combined with NGS analysis reveals genomic regulatory regions that physically interact with the Pax5 promoter in a chicken B cell line

    Toshitsugu Fujita, Fusako Kitaura, Miyuki Yuno, Yutaka Suzuki, Sumio Sugano, Hodaka Fujii

    DNA RESEARCH   24 ( 5 )   537 - 548   2017.10

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  • Identification of physical interactions between genomic regions by enChIP-Seq

    Toshitsugu Fujita, Miyuki Yuno, Yutaka Suzuki, Sumio Sugano, Hodaka Fujii

    GENES TO CELLS   22 ( 6 )   506 - 520   2017.6

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  • The role of platelet and endothelial GARP in thrombosis and hemostasis

    Elien Vermeersch, Frederik Denorme, Wim Maes, Simon F. De Meyer, Karen Vanhoorelbeke, Justin Edwards, Ethan M. Shevach, Derya Unutmaz, Hodaka Fujii, Hans Deckmyn, Claudia Tersteeg

    PLOS ONE   12 ( 3 )   e0173329 - e0173329   2017.3

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  • Allele-specific locus binding and genome editing by CRISPR at the p16INK4a locus

    Toshitsugu Fujita, Miyuki Yuno, Hodaka Fujii

    SCIENTIFIC REPORTS   6   30485 - 30485   2016.7

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  • Efficient sequence-specific isolation of DNA fragments and chromatin by in vitro enChIP technology using recombinant CRISPR ribonucleoproteins

    Toshitsugu Fujita, Miyuki Yuno, Hodaka Fujii

    GENES TO CELLS   21 ( 4 )   370 - 377   2016.2

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  • Identification of Non-Coding RNAs Associated with Telomeres Using a Combination of enChIP and RNA Sequencing

    Toshitsugu Fujita, Miyuki Yuno, Daisuke Okuzaki, Rieko Ohki, Hodaka Fujii

    PLOS ONE   10 ( 4 )   e0123387 - e0123387   2015.4

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  • A Critical Role of the Thy28-MYH9 Axis in B Cell-Specific Expression of the Pax5 Gene in Chicken B Cells

    Toshitsugu Fujita, Fusako Kitaura, Hodaka Fujii

    PLOS ONE   10 ( 1 )   e0116579   2015.1

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  • Efficient isolation of specific genomic regions retaining molecular interactions by the iChIP system using recombinant exogenous DNA-binding proteins

    Toshitsugu Fujita, Hodaka Fujii

    BMC MOLECULAR BIOLOGY   15   26   2014.11

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  • Oligoribonucleotide (ORN) Interference-PCR (ORNi-PCR): A Simple Method for Suppressing PCR Amplification of Specific DNA Sequences Using ORNs

    Naoki Tanigawa, Toshitsugu Fujita, Hodaka Fujii

    PLOS ONE   9 ( 11 )   e113345   2014.11

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  • Identification of Proteins Associated with an IFN gamma-Responsive Promoter by a Retroviral Expression System for enChIP Using CRISPR

    Toshitsugu Fujita, Hodaka Fujii

    PLOS ONE   9 ( 7 )   e103084   2014.7

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  • Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation

    Justin P. Edwards, Hodaka Fujii, Angela X. Zhou, John Creemers, Derya Unutmaz, Ethan M. Shevach

    Journal of Immunology   190 ( 11 )   5506 - 5515   2013.6

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  • GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo

    Angela X Zhou , Lina Kozhaya, Hodaka Fujii, Derya Unutmaz

    Journal of Immunology   190 ( 10 )   5057 - 5064   2013.5

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  • Discovery and characterization of new transcripts from RNA-seq data in mouse CD4(+) T cells

    Andrew Paul Hutchins, Stephane Poulain, Hodaka Fujii, Diego Miranda-Saavedra

    GENOMICS   100 ( 5 )   303 - 313   2012.11

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  • Transcription start sites and usage of the first exon of mouse Foxp3 gene

    Toshitsugu Fujita, Hodaka Fujii

    MOLECULAR BIOLOGY REPORTS   39 ( 10 )   9613 - 9619   2012.10

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  • Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction through ERK1/2 pathway

    Farha M. Juliana, Hidetoshi Nara, Tadashi Onoda, Mizanur Rahman, Akemi Araki, Lianjin Jin, Hodaka Fujii, Nobuyuki Tanaka, Tomoaki Hoshino, Hironobu Asao

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   420 ( 3 )   628 - 634   2012.4

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  • Species-specific 5 '-genomic structure and multiple transcription start sites in the chicken Pax5 gene

    Toshitsugu Fujita, Hodaka Fujii

    GENE   477 ( 1-2 )   24 - 31   2011.5

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  • Novel reporter cell line to analyze cytokine-mediated expression regulation of c-myc gene

    Hodaka Fujii

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   108 ( 5 )   438 - 440   2009.11

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  • Expression of GARP selectively identifies activated human FOXP3+regulatory T cells

    Rui Wang, Lina Kozhaya, Frances Mercer, Alka Khaitan, Hodaka Fujii, Derya Unutmaz

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   106 ( 32 )   13439 - 13444   2009.8

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  • Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon

    Shella Saint Fleur, Akemi Hoshino, Kimie Kondo, Takeshi Egawa, Hodaka Fujii

    BLOOD   114 ( 7 )   1355 - 1365   2009.8

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  • Lack of nuclear translocation of cytoplasmic domains of IL-2/IL-15 receptor subunits

    Hodaka Fujii, Akemi Hoshino

    CYTOKINE   46 ( 3 )   302 - 308   2009.6

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  • Identification of a Regulatory T Cell Specific Cell Surface Molecule that Mediates Suppressive Signals and Induces Foxp3 Expression

    Rui Wang, Qi Wan, Lina Kozhaya, Hodaka Fujii, Derya Unutmaz

    PLOS ONE   3 ( 7 )   e2705   2008.7

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  • Receptor expression is essential for proliferation induced by dimerized Jak kinases

    Hodaka Fujii

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   370 ( 4 )   557 - 560   2008.6

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  • Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite

    Agam Prasad Singh, Carlos A. Buscaglia, Qian Wang, Agata Levay, Daniel R. Nussenzweig, John R. Walker, Elizabeth A. Winzeler, Hodaka Fujii, Beatriz M. A. Fontoura, Victor Nussenzweig

    CELL   131 ( 3 )   492 - 504   2007.11

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  • Temporal regulation of Stat5 activity in determination of cell differentiation program

    Akemi Hoshino, Hodaka Fujii

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   358 ( 3 )   914 - 919   2007.7

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  • Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction

    Hodaka Fujii

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   354 ( 3 )   825 - 829   2007.3

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  • Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon

    Akemi Hoshino, Hodaka Fujii

    FEBS LETTERS   581 ( 5 )   975 - 980   2007.3

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  • Nuclear translocation of 2-amino-3-ketobutyrate coenzyme A ligase by cold and osmotic stress

    HOSHINO A, FUJII H

    CELL STRESS & CHAPERONES   12 ( 2 )   186 - 191   2007.1

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  • Regulation of Stat1 protein expression by phenylalanine 172 in the coiled-coil domain

    Akerni Hoshino, Shella Saint Fleur, Hodaka Fujii

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   346 ( 3 )   1062 - 1066   2006.8

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  • Inducible translocation trap: A system for detecting inducible nuclear translocation

    A Hoshino, S Matsumura, K Kondo, JA Hirst, H Fujii

    MOLECULAR CELL   15 ( 1 )   153 - 159   2004.7

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  • Enforced expression of the Ikaros isoform IK5 decreases the numbers of extrathymic intraepithelial lymphocytes and natural killer 1.1(+) T cells

    SN Tucker, HK Jessup, H Fujii, CB Wilson

    BLOOD   99 ( 2 )   513 - 519   2002.1

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  • Defective expression of the interleukin-2/interleukin-15 receptor beta subunit leads to a natural killer cell-deficient form of severe combined immunodeficiency

    KC Gilmour, H Fujii, T Cranston, EG Davies, C Kinnon, HB Gaspar

    BLOOD   98 ( 3 )   877 - 879   2001.8

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  • Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function

    S Tsujino, JP Di Santo, A Takaoka, TL McKernan, S Noguchi, C Taya, H Yonekawa, T Saito, T Taniguchi, H Fujii

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   97 ( 19 )   10514 - 10519   2000.9

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  • Critical role of the membrane-proximal, proline-rich motif of the interleukin-2 receptor gamma c chain in the Jak3-independent signal transduction

    S Tsujino, T Miyazaki, A Kawahara, M Maeda, T Taniguchi, H Fujii

    GENES TO CELLS   4 ( 6 )   363 - 373   1999.6

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  • Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling

    A Takaoka, N Tanaka, Y Mitani, T Miyazaki, H Fujii, M Sato, P Kovarik, T Decker, J Schlessinger, T Taniguchi

    EMBO JOURNAL   18 ( 9 )   2480 - 2488   1999.5

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  • Functional dissection of the cytoplasmic subregions of the IL-2 receptor beta c chain in primary lymphocyte populations

    H Fujii, K Ogasawara, H Otsuka, M Suzuki, K Yamamura, T Yokochi, T Miyazaki, H Suzuki, TW Mak, S Taki, T Taniguchi

    EMBO JOURNAL   17 ( 22 )   6551 - 6557   1998.11

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  • Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway

    T Miyazaki, A Takaoka, L Nogueira, Dikic, I, H Fujii, S Tsujino, Y Mitani, M Maeda, J Schlessinger, T Taniguchi

    GENES & DEVELOPMENT   12 ( 6 )   770 - 775   1998.3

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  • ACTIVATION OF STAT5 BY INTERLEUKIN-2 REQUIRES A CARBOXYL-TERMINAL REGION OF THE INTERLEUKIN-2 RECEPTOR-BETA CHAIN BUT IS NOT ESSENTIAL FOR THE PROLIFERATIVE SIGNAL TRANSMISSION

    H FUJII, Y NAKAGAWA, U SCHINDLER, A KAWAHARA, H MORI, F GOUILLEUX, B GRONER, JN IHLE, Y MINAMI, T MIYAZAKI, T TANIGUCHI

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   92 ( 12 )   5482 - 5486   1995.6

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  • FUNCTIONAL ACTIVATION OF JAK1 AND JAK3 BY SELECTIVE ASSOCIATION WITH IL-2 RECEPTOR SUBUNITS

    T MIYAZAKI, A KAWAHARA, H FUJII, Y NAKAGAWA, Y MINAMI, ZJ LIU, OISHI, I, O SILVENNOINEN, BA WITTHUHN, JN IHLE, T TANIGUCHI

    SCIENCE   266 ( 5187 )   1045 - 1047   1994.11

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  • REGULATION OF PROTEIN-KINASE-C ISOFORM PROTEINS IN PHORBOL ESTER-STIMULATED JURKAT T-LYMPHOMA CELLS

    A TSUTSUMI, M KUBO, H FUJII, J FREIREMOAR, CW TURCK, JT RANSOM

    JOURNAL OF IMMUNOLOGY   150 ( 5 )   1746 - 1754   1993.3

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Books

  • Handbook of Epigenetics: The New Molecular and Medical Genetics, 3rd edition

    Toshitsugu Fujita, Hodaka Fujii( Role: Joint author ,  Chapter 42: New Directions for Epigenetics: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research)

    Academic Press (Elsevier)  2022.9 

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    Language:English Book type:Scholarly book

  • Standard Protocols on Genome Editing

    Toshitsugu Fujita, Hodaka Fujii( Role: Contributor ,  Sequence-specific isolation of DNA using CRISPR)

    YODOSHA  2019.12 

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    Language:Japanese Book type:Scholarly book

  • 医療応用をめざすゲノム編集 最新動向から技術・倫理的課題まで

    藤田 敏次、藤井 穂高( Role: Joint author)

    化学同人  2018.6 

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    Language:Japanese Book type:Scholarly book

  • Handbook of Epigenetics: The New Molecular and Medical Genetics, 2nd edition

    Toshitsugu Fujita, Hodaka Fujii( Role: Joint author ,  Chapter 42. New Directions for Epigenetics: Application of Engineered DNA-Binding Molecules to Locus-Specific Epigenetic Research)

    Academic Press  2017.7 

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    Language:English Book type:Scholarly book

  • All About ゲノム編集

    藤井 穂高( Role: Joint author)

    羊土社  2016.12 

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    Language:Japanese Book type:Scholarly book

  • 進化するゲノム編集技術

    藤田 敏次, 藤井 穂高( Role: Joint author)

    (株)エヌ・ティー・エス  2015.10 

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    Language:Japanese Book type:Scholarly book

  • Chromatin Protocols, Third Edition

    Toshitsugu Fujita, Hodaka Fujii( Role: Joint author)

    Humana Press  2015.4 

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    Language:English Book type:Scholarly book

  • 今すぐ始めるゲノム編集

    藤井 穂高( Role: Contributor ,  TALやCRISPRを用いたenChIP法による特定ゲノム領域の単離と結合分子の同定)

    羊土社  2014.3 

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    Language:Japanese Book type:Scholarly book

  • エピジェネティクスと病気

    藤井 穂高( Role: Contributor ,  iChIP法による特定ゲノム領域の単離と結合分子の同定)

    メディカルドゥ  2013.8 

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Review Papers

  • 研究者の視野を広げる起業体験

    藤井 穂高

    実験医学   40 ( 13 )   2188 - 2191   2022.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher:羊土社   Kind of work:Single Work  

  • Oligoribonucleotide interference-PCR: principles and applications

    Shimizu T, Fujita T, Fujii H

    Biology Methods & Protocols   7 ( 1 )   bpac010   2022.5

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:Oxford University Press   Kind of work:Joint Work  

  • Locus-specific genomic DNA purification using the CRISPR system: methods and applications

    Hirotaka Fujita, Toshitsugu Fujita, Hodaka Fujii

    4 ( 2 )   290 - 300   2021.4

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  • Purification of specific DNA species using the CRISPR system

    Toshitsugu Fujita, Hodaka Fujii

    Biology Methods and Protocols (BIOMAP)   4 ( 1 )   bpz008   2019.7

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:Oxford University Press   Kind of work:Joint Work  

  • Biochemical analyses of molecular mechanisms of regulation of genome functions using the locus-specific chromatin immunoprecipitation technologies

    Hodaka Fujii

    Hirosaki Medical Journal   69 ( 1-4 )   10 - 18   2019.3

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  • In vitro Engineered DNA-binding Molecule-mediated Chromatin Immunoprecipitation (in vitro enChIP) Using CRISPR Ribonucleoproteins in Combination with Next-generation Sequencing (in vitro enChIP-Seq) for the Identification of Chromosomal Interactions

    Toshitsugu Fujita, Hodaka Fujii

    Bio-Protocol   7 ( 22 )   2017.11

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:Bio-protocol LLC   Kind of work:Joint Work  

  • Identification of molecules associated with specific genomic regions and analysis of higher-order chromosome conformation using the locus-specific chromatin immunoprecipitation technology

    Toshitsugu Fujita, Hodaka Fujii

    68 ( 3 )   189 - 193   2017.6

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  • Isolation of Specific Genomic Regions and Identification of Associated Molecules by enChIP

    Toshitsugu Fujita, Hodaka Fujii

    Journal of Visualized Experiments   ( 107 )   e53478   2016.1

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    PubMed

  • Biochemical Analysis of Genome Functions Using Locus-Specific Chromatin Immunoprecipitation Technologies

    Toshitsugu Fujita, Hodaka Fujii

    Gene Regulation and Systems Biology   10 ( Suppl 1 )   1 - 9   2016.1

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:SAGE Publishing   Kind of work:Joint Work  

    PubMed

  • 遺伝子座特異的クロマチン免疫沈降法によるエピジェネティック創薬

    藤井 穂高

    化学工業   66 ( 12月 )   2015.12

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  • Applications of Engineered DNA-Binding Molecules Such as TAL Proteins and the CRISPR/Cas System in Biology Research

    Toshitsugu Fujita, Hodaka Fujii

    International Journal of Molecular Sciences   16 ( 10 )   23143 - 23164   2015.9

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    PubMed

  • Isolation of Specific Genomic Regions and Identification of Their Associated Molecules by Engineered DNA-Binding Molecule-Mediated Chromatin Immunoprecipitation (enChIP) Using the CRISPR System and TAL Proteins

    Hodaka Fujii, Toshitsugu Fujita

    International Journal of Molecular Sciences   16 ( 9 )   21802 - 21812   2015.9

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  • Analysis of mechanisms of epigenetic regulation by combining disciplines of science/technology and life science : locus-specific biochemical epigenetics by insertional chromatin immunoprecipitation (iChIP)

    1 - 8   2015

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    Language:Japanese   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Kind of work:Single Work  

    CiNii Books

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  • CRISPR/Casのゲノム編集以外への応用

    藤田 敏次, 藤井 穂高

    実験医学   32 ( 11 )   1732 - 1736   2014.6

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  • Identification of proteins interacting with genomic regions of interest in vivo using engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP)

    藤田 敏次、藤井 穂高

    Bio-protocol   4 ( 10 )   2014.5

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  • 挿入的クロマチン免疫沈降法 (iChIP) による特定ゲノム領域結合分子の網羅的同定

    藤田 敏次, 藤井 穂高

    実験医学   31 ( 16 )   2629 - 2636   2013.9

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  • Locus-specific biochemical epigenetics/chromatin biochemistry by insertional chromatin immunoprecipitation

    Toshitsugu Fujita, Hodaka Fujii

    ISRN Biochemistry   2013   913273   2013.1

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  • Cytokine-induced nuclear translocation of signaling proteins and their analysis using the inducible translocation trap system

    Shella Saint Fleur, Hodaka Fujii

    41 ( 3 )   187 - 197   2008.3

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  • Mechanisms of signal transduction from receptors of Type I and Type II cytokines

    Hodaka Fujii

    4 ( 1 )   69 - 76   2007.1

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  • IL-2 signaling involves recruitment and activation of multiple protein tyrosine kinases by the IL-2 receptor

    Tadatsugu Taniguchi, Tadaaki Miyazaki, Yasuhiro Minami, Atsuo Kawahara, Hodaka Fujii, Yoko Nakagawa, Masanori Hatakeyama, Zhao-Jun Liu

    766   235 - 244   1995.9

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  • IL-2 SIGNALING - FUNCTIONAL ACTIVATION OF JAK1 AND JAK3 KINASES THROUGH SELECTIVE ASSOCIATION WITH THE IL-2IR BETA AND GAMMA CHAINS

    T MIYAZAKI, A KAWAHARA, H FUJII, Y NAKAGAWA, Y MINAMI, ZJ LIU, OISHI, I, EL BARSOUMIAN, O SILVENNOINEN, BA WITTHUHN, JN IHLE, T TANIGUCHI

    JOURNAL OF CELLULAR BIOCHEMISTRY   78 - 78   1995.3

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Awards

  • Addgene Blue Flame Award

    2016.06

  • 大阪大学総長奨励賞

    2015.07

  • 学術振興会特別研究員等審査会専門委員表彰

    2015

  • 大阪大学総長奨励賞

    2014.07

  • The American Association of Immunologists Junior Faculty Travel Award

    2007

  • 東京大学医師会医学賞

    1996

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