Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation.

Atsushi Inose-Maruyama, Shuya Kasai, Ken Itoh

Methods in molecular biology (Clifton, N.J.)   2651   157 - 166   2023

Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment

Yota Tatara, Hiromi Yamazaki, Fumiki Katsuoka, Mitsuru Chiba, Daisuke Saigusa, Shuya Kasai, Tomohiro Nakamura, Jin Inoue, Yuichi Aoki, Miho Shoji, Ikuko N Motoike, Yoshinori Tamada, Katsuhito Hashizume, Mikio Shoji, Kengo Kinoshita, Koichi Murashita, Shigeyuki Nakaji, Masayuki Yamamoto, Ken Itoh

71 ( 1 )   103367   2022.10

Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice

Sunao Shimizu, Shuya Kasai, Hiromi Yamazaki, Yota TATARA, Junsei Mimura, Máté János Engler, Kunikazu Tanji, Yoshikazu Nikaido, Takuro Inoue, Hiroyuki Suganuma, Koichi Wakabayashi, Ken Itoh

International Journal of Molecular Sciences   23 ( 15 )   2022.7

Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage

Jun Liu, Shuya Kasai, Yota Tatara, Hiromi Yamazaki, Junsei Mimura, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Kunikazu Tanji, Koichi Wakabayashi, Hayato Maeda, Hiroki Mizukami, Yasuhiro Shinkai, Yoshito Kumagai, Hirofumi Tomita, Ken Itoh

International Journal of Molecular Sciences   23 ( 6 )   3201 - 3201   2022.3

Association of mitochondrial DNA haplogroup and hearing impairment with aging in Japanese general population of the Iwaki Health Promotion Project

Shiori Miura, Akira Sasaki, Shuya Kasai, Takayuki Sugawara, Yasunori Maeda, Shinichi Goto, Takashi Kasai, Nami Shimizume, Songee Jung, Takuro Iwane, Ken Itoh, Atsushi Matsubara

Journal of Human Genetics   67 ( 6 )   369 - 375   2022.1

Direct protein–protein interaction between Npas4 and IPAS mutually inhibits their critical roles in neuronal cell survival and death

Shuya Kasai, Xianyu Li, Satoru Torii, Ken-ichi Yasumoto and Kazuhiro Sogawa

Cell Death Discovery   2021.10

多層オミックスと機械学習による軽度認知障害の予測モデルの構築

多田羅 洋太, 中村 智洋, 千葉 満, 三枝 大輔, 山嵜 博未, 勝岡 史城, 葛西 秋宅, 川瀬 倫子, 本間 リナ, 松田 りら, 藤本 哲太, 荘司 美穂, 元池 育子, 玉田 嘉紀, 橋爪 克仁, 東海林 幹夫, 木下 賢吾, 伊東 健

Dementia Japan   35 ( 4 )   660 - 660   2021.10

Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis

Mayu Sugawara, Takumi Abe, Shuya Kasai, Ken Itoh, Taku Ozaki

Biochemistry and Biophysics Reports   27   101101 - 101101   2021.8

Attenuation of inhibitory PAS domain protein-induced cell death by synthetic peptides derived from Mcl-1 transmenbrane domain

Shuya Kasai, Ken-ichi Yasumoto, Kazuhiro Sogawa

CELL DEATH DISCOVERY   7 ( 1 )   92   2021.5

The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress

Marie-France Dorion, Mukandila Mulumba, Shuya Kasai, Ken Itoh, William D. Lubell, Huy Ong

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY   2021   6691402   2021.3

Nrf2とATF4の相互作用を基盤にした未病気における疾患予防法の開発

葛西 秋宅

BIO Clinica   36   80 - 84   2021

特集 慢性腎臓病・透析患者の酸化ストレス-最新知見と治療展開 2.慢性腎臓病における酸化ストレス進展機序(1) 慢性腎臓病におけるNrf2-Keap1 経路の役割-CKD 治療薬としての期待

伊東 健, Liu Jun, 葛西 秋宅

臨床透析   36 ( 12 )   1521 - 1527   2020.11

Prevalence of the mitochondrial 1555 A > G and 1494 C > T mutations in a community-dwelling population in Japan (vol 7, 27, 2020)

Yasunori Maeda, Akira Sasaki, Shuya Kasai, Shinichi Goto, Shin-ya Nishio, Kaori Sawada, Itoyo Tokuda, Ken Itoh, Shin-ichi Usami, Atsushi Matsubara

HUMAN GENOME VARIATION   7 ( 1 )   27 - 27   2020.10

Prevalence of the mitochondrial 1555 A>G and 1494 C>T mutations in a community-dwelling population in Japan.

Maeda Y, Sasaki A, Kasai S, Goto S, Nishio SY, Sawada K, Tokuda I, Itoh K, Usami SI, Matsubara A.

Hum Genome Var.   2020.9

Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging.

Shimizu S, Mimura J, Hasegawa T, Shimizu E, Imoto S, Tsushima M, Kasai S, Yamazaki H, Ushida Y, Suganuma H, Tomita H, Yamamoto M, Nakaji S, Itoh K.

PLoS One.   2020.8

多層オミックス解析による認知症の早期発見のためのバイオマーカー探索

多田羅 洋太, 中村 智洋, 山嵜 博未, 勝岡 史城, 千葉 満, 三枝 大輔, 葛西 秋宅, 伊東 健

JSBMS Letters   45 ( Suppl. )   32 - 32   2020.8

Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice

Hiromi Yamazaki, David Ron, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Kunikazu Tanji, Koichi Wakabayashi, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Douglas R. Cavener, Masayuki Yamamoto, Ken Itoh

PLOS Genetics   16 ( 4 )   e1008693   2020.4

Mitochondrial E3 Ubiquitin Ligase Parkin: Relationships with Other Causal Proteins in Familial Parkinson’s Disease and Its Substrate-Involved Mouse Experimental Models

Satoru Torii, Shuya Kasai, Tatsushi Yoshida, Ken-ichi Yasumoto, Shigeomi Shimizu

International Journal of Molecular Sciences   21 ( 4 )   1202 - 1202   2020.2

ストレス応答性転写因子Nrf2とATF4の相互作用を基盤にした疾患予防・アンチエイジング法の開発

葛西 秋宅

BIO Clinica   35   60 - 64   2020

Deficiency of P62/SQSTM1 Exacerbates Doxorubicin-Induced Cardiac Dysfunction

Michiko Tsushima, Junsei Mimura, Jun Liu, Hiromi Yamazaki, Shuya Kasai, Hirofumi Tomita, Ken Itoh

CIRCULATION   140   2019.11

Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes.

Junsei Mimura, Atsushi Inose-Maruyama, Shusuke Taniuchi, Kunio Kosaka, Hidemi Yoshida, Hiromi Yamazaki, Shuya Kasai, Nobuhiko Harada, Randal J Kaufman, Seiichi Oyadomari, Ken Itoh

International journal of molecular sciences   20 ( 7 )   1706   2019.4

Deficiency of protein-L-isoaspartate (D-aspartate) O-methyl-transferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma.

Masahiro Yamashita, Masahito Ogasawara, Yasushi Kawasaki, Miyuki Niisato, Heisuke Saito, Shuya Kasai, Chihaya Maesawa, Makoto Maemondo, Kohei Yamauchi

Oncotarget   9 ( 17 )   13287 - 13300   2018.3

Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease.

Shuya Kasai, Junsei Mimura, Taku Ozaki, Ken Itoh

Frontiers in veterinary science   5   242 - 242   2018

Increase in proapoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2.

Shuya Kasai, Mary J E Richardson, Satoru Torii, Ken-Ichi Yasumoto, Hiroki Shima, Kazuhiko Igarashi, Ken Itoh, Kazuhiro Sogawa, Kazutaka Murayama

The FEBS journal   284 ( 23 )   4115 - 4127   2017.12

Bcl-2/Bcl-xL inhibitor ABT-737 sensitizes pancreatic ductal adenocarcinoma to paclitaxel-induced cell death.

Shuya Kasai, Takuya Sasaki, Ayano Watanabe, Masao Nishiya, Shinji Yasuhira, Masahiko Shibazaki, Chihaya Maesawa

Oncology letters   14 ( 1 )   903 - 908   2017.7

Conformational changes in inhibitory PAS domain protein associated with binding of HIF-1α and Bcl-xL in living cells.

Shuya Kasai, Shinji Kajimoto, Yuma Ito, Tomo Saito, Ken-Ichi Yasumoto, Makio Tokunaga, Kumiko Sakata-Sogawa, Hiroshi Fukumura, Kazuhiro Sogawa

Journal of biochemistry   161 ( 3 )   291 - 296   2017.3

NAD(P)H: Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG

Shuya Kasai, Nobuyuki Arakawa, Ayaka Okubo, Wataru Shigeeda, Shinji Yasuhira, Tomoyuki Masuda, Toshihide Akasaka, Masahiko Shibazaki, Chihaya Maesawa

PLOS ONE   11 ( 4 )   e0153181   2016.4

Temporal expression in rats of receptor tyrosine kinase Tie2 during early wound healing after tooth extraction

Hirotaka Sato, Shuya Kasai, Chihaya Maesawa

JOURNAL OF ORAL SCIENCE   57 ( 4 )   313 - 318   2015.12

Inhibitory PAS domain protein is a substrate of PINK1 and Parkin and mediates cell death in a Parkinson's disease model.

S Kasai, S Torii, A Kakita, K Sogawa

Cell death & disease   6   e1886 - e1886   2015.9

Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification.

Yoshinori Tatemichi, Masahiko Shibazaki, Shinji Yasuhira, Shuya Kasai, Hiroshi Tada, Hiroki Oikawa, Yuji Suzuki, Yasuhiro Takikawa, Tomoyuki Masuda, Chihaya Maesawa

Cancer science   106 ( 7 )   848 - 856   2015.7

Temporal expression in rats of receptor tyrosine kinase Tie2 during early wound healing after tooth extraction.

Hirotaka Sato, Shuya Kasai, Chihaya Maesawa

Journal of oral science   57 ( 4 )   313 - 318   2015

Involvement of inhibitory PAS domain protein in neuronal cell death in Parkinson's disease.

Torii S, Kasai S, Suzuki A, Todoroki Y, Yokozawa K, Yasumoto KI, Seike N, Kiyonari H, Mukumoto Y, Kakita A, Sogawa K

Cell death discovery   1   15015   2015

Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.

Shinpei Miura, Chihaya Maesawa, Masahiko Shibazaki, Shinji Yasuhira, Syuya Kasai, Kanako Tsunoda, Fumihiko Maeda, Kazuhiro Takahashi, Toshihide Akasaka, Tomoyuki Masuda

The American Journal of dermatopathology   36 ( 3 )   211 - 216   2014.3

A somatic mutation of the KEAP1 gene in malignant melanoma is involved in aberrant NRF2 activation and an increase in intrinsic drug resistance.

Shinpei Miura, Masahiko Shibazaki, Shuya Kasai, Shinji Yasuhira, Ayano Watanabe, Tsuyoshi Inoue, Yuich Kageshita, Kanako Tsunoda, Kazuhiro Takahashi, Toshihide Akasaka, Tomoyuki Masuda, Chihaya Maesawa

The Journal of investigative dermatology   134 ( 2 )   553 - 556   2014.2

Dephosphorylation of Sp1 at Ser-59 by protein phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole.

Shuji Shimoyama, Shuya Kasai, Brigitte Kahn-Perlès, Hideaki Kikuchi

Biochimica et biophysica acta   1839 ( 2 )   107 - 115   2014.2

BCL2 and BCLxL are key determinants of resistance to antitubulin chemotherapeutics in melanoma cells

Ayano Watanabe, Shinji Yasuhira, Tsuyoshi Inoue, Shuya Kasai, Masahiko Shibazaki, Kazuhiro Takahashi, Toshihide Akasaka, Tomoyuki Masuda, Chihaya Maesawa

EXPERIMENTAL DERMATOLOGY   22 ( 8 )   518 - 523   2013.8

Beta-catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells.

Kasai S, Ishigaki T, Takumi R, Kamimura T, Kikuchi H

Biochimica et biophysica acta   1830 ( 3 )   2509 - 2516   2013.3

Transcriptional and post-transcriptional regulation of beta III-tubulin protein expression in relation with cell cycle-dependent regulation of tumor cells

Masahiko Shibazaki, Chihaya Maesawa, Kiyomi Akasaka, Shuya Kasai, Shinji Yasuhira, Kiminori Kanno, Ikue Nakayama, Toru Sugiyama, Go Wakabayasi, Tomoyuki Masuda, Nozomu Mori

INTERNATIONAL JOURNAL OF ONCOLOGY   40 ( 3 )   695 - 702   2012.3

Correlation of dysfunction of nonmuscle myosin IIA with increased induction of Cyp1a1 in Hepa-1 cells

Masayuki Ebina, Masahiko Shibazaki, Kyoko Kudo, Shuya Kasai, Hideaki Kikuchi

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS   1809 ( 3 )   176 - 183   2011.3

Hepa-1細胞における非筋細胞ミオシンIIAの阻害または喪失はTCDDによるCyp1a1誘導を促進する(Inhibition or depletion of Nonmuscle myosin IIA leads to enhancement of Cyp1a1 induction by TCDD in Hepa-1 cells)

蝦名 真行, 柴崎 晶彦, 工藤 恭子, 葛西 秋宅, 菊池 英明

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   83回・33回   1P - 0676   2010.12

The Inhibitory Mechanisms of the Tyrosine Kinase Inhibitors Herbimycin A, Genistein, and Tyrphostin B48 with Regard to the Function of the Aryl Hydrocarbon Receptor in Caco-2 Cells

Shuya Kasai, Hideaki Kikuchi

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   74 ( 1 )   36 - 43   2010.1

Calcium/calmodulin signaling elicits release of cytochrome c during 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptosis in the human lymphoblastic T-cell line, L-MAT

Daisuke Kobayashi, Sohel Ahmed, Masato Ishida, Shuya Kasai, Hideaki Kikuchi

TOXICOLOGY   258 ( 1 )   25 - 32   2009.4

Novel disease intervention in Mibyou stage based on the interaction of stress-inducible protein Nrf2 and ATF4

Shuya Kasai, Yota Tatara, Junsei Mimura and Ken Itoh

36 ( 1 )   80 - 84   2021.1

慢性腎臓病における酸化ストレス進展機序 (1) 慢性腎臓病におけるNrf2-Keap1経路の役割―CKD治療薬としての期待

伊東 健、Liu Jun、葛西 秋宅

臨床透析   36 ( 12 )   1521 - 1527   2020.11

Novel disease intervention and anti-aging strategy based on the interaction of stress-inducible protein Nrf2 and ATF4

Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura and Ken Itoh.

35 ( 10 )   60 - 64   2020.9

多層オミックス解析による認知症の早期発見のためのバイオマーカー探索

多田羅 洋太, 中村 智洋, 山嵜 博未, 勝岡 史城, 千葉 満, 三枝 大輔, 葛西 秋宅, 伊東 健

JSBMS Letters   45 ( Suppl. )   32 - 32   2020.8

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology.

Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura and Ken Itoh

Biomolecules   2020.2

Mitochondrial E3 Ubiquitin Ligase Parkin: Relationships with Other Causal Proteins in Familial Parkinson’s Disease and Its Substrate‐Involved Mouse Experimental Models

Satoru Torii, Shuya Kasai, Tatsushi Yoshida, Ken‐ichi Yasumoto and Shigeomi Shimizu

International Journal of Molecular Sciences   21   1202   2020.2

Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control

Shuya Kasai, Hiromi Yamazaki, Kunikazu Tanji, Máté János Engler, Tomoh Matsumiya and Ken Itoh

Journal of clinical biochemistry and nutrition   64 ( 1 )   1 - 12   2019.1

Emerging Regulatory Role of Nrf2 in Iron, Home, and Hemoglobin Metabolism in Physiology and Disease

Shuya Kasai, Junsei Mimura, Taku Ozaki, Ken Itoh

Frontiers in veterinary science.   5   242 - 242   2018.10

Regulation of mitochondrial homeostasis by ATF4 and Nrf2

Shuya Kasai, Michiko Tsushima, Ken Itoh

Experimental Medicine   36 ( 5 )   103 - 107   2018.3

PINK1-ParkinによるIPAS分解が神経細胞死を抑制する

葛西 秋宅, 鳥居 暁, 安元 研一, 柿田 明美, 十川 和博

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   88回・38回   [1P0437] - [1P0437]   2015.12

AhRの活性化過程におけるHDAC6の関与

小林葵, 下山修司, 葛西秋宅, 菊池英明

日本生化学会大会(Web)   88th   2015