Updated on 2024/02/26

写真a

 
Shimoyama Shuji
 
Affiliation
Graduate School of Medicine F F
Date of Birth
1982
Laboratory Phone number
+81-172-39-5138
Laboratory Fax number
+81-172-39-5138
External link

Degree

  • 博士(学術)

  • 農学(修士)

  • 農学(学士)

Research Interests

  • Neuroscience

  • Biochemistry

  • Molecular biology

  • 自閉症スペクトラム障害

  • 遺伝子発現

  • 自閉症

  • GABA

  • スクリーニング

  • トランスクリプトーム

  • S-palmitoylation

  • マイクロアレイ

  • ミクログリア

  • 神経科学

Research Areas

  • Life Science / Molecular biology

  • Life Science / Molecular biology

  • Life Science / Functional biochemistry

  • Life Science / Neuroscience-general

  • Life Science / Pharmaceutical chemistry and drug development sciences

Professional Memberships

  • 日本神経科学会

  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

  • THE JAPANESE BIOCHEMICAL SOCIETY

  • JAPAN BRAIN SCIENCE SOCIETY

  • 弘前医学

Papers

  • Sex-related differences in the effect of exercise on protein profiles of serum

    Tomonori Furukawa, Shuji Shimoyama, Aogi Kobayashi, Yota Tatara, Yoshikazu Nikaido, Shinya Ueno

    Hirosaki Medical Journal   74   2024.3

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  • Benzodiazepine-induced cell growth inhibition via GABAA receptor- and TSPO-independent pathways

    Shuji Shimoyama, Tomonori Furukawa, Shinya Ueno

    Hirosaki Medical Journal   74   52 - 60   2024.3

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    Language:English   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Effect of Ionizing Radiation on the Intercellular Network of Murine Cerebral Cortical Neurons

    Masaru Yamaguchi, Takakiyo Tsujiguchi, Tomonori Furukawa, Shuji Shimoyama, Toshiya Nakamura, Yasushi Mariya and Junko Yamada

    Radiation Environment and Medicine   12 ( 1 )   2023.2

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  • Intraperitoneal Administration of Etizolam Improves Locomotor Function in Mice After Spinal Cord Injury

    Kenya Saruta, Tatsuhiro Fukutoku, Gentaro Kumagai, Toshihide Nagaoki, Manami Tsukuda, Yohshiro Nitobe, Kanichiro Wada, Toru Asari, Taku Fujita, Isamu Sasaki, Yoshikazu Nikaido, Shuji Shimoyama, Shinya Ueno, Yasuyuki Ishibashi

    Neurotrauma Reports   4 ( 1 )   2023.2

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  • TRPA1 as a O(2) sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex.

    Kawabata R, Shimoyama S, Ueno S, Yao I, Arata A, Koga K

    Scientific reports   13 ( 1 )   2960   2023.2

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    PubMed

  • Pathological substrate of memory impairment in multiple system atrophy.

    Yasuo Miki, Kunikazu Tanji, Kana Shinnai, Makoto T Tanaka, Firat Altay, Sandrine C Foti, Catherine Strand, Takanori Sasaki, Tomoya Kon, Shuji Shimoyama, Tomonori Furukawa, Haruo Nishijima, Hiromi Yamazaki, Yasmine T Asi, Conceição Bettencourt, Zane Jaunmuktane, Mari Tada, Fumiaki Mori, Hiroki Mizukami, Masahiko Tomiyama, Hilal A Lashuel, Tammaryn Lashley, Akiyoshi Kakita, Helen Ling, Andrew J Lees, Janice L Holton, Thomas T Warner, Koichi Wakabayashi

    Neuropathology and applied neurobiology   48 ( 7 )   e12844   2022.7

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  • The role of neutrophil gelatinase-associated lipocalin and iron homeostasis in object recognition impairment in aged sepsis-survivor rats.

    Nikaido Y, Midorikawa Y, Furukawa T, Shimoyama S, Takekawa D, Kitayama M, Ueno S, Kushikata T, Hirota K

    12 ( 1 )   249   2022.1

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  • Impaired Cognitive Function and Hippocampal Changes Following Chronic Diazepam Treatment in Middle-Aged Mice.

    Furukawa T, Nikaido Y, Shimoyama S, Masuyama N, Notoya A, Ueno S

    Frontiers in aging neuroscience   13   777404   2021.11

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  • Copy number variations in Japanese children with autism spectrum disorder.

    Yui Sakamoto, Shuji Shimoyama, Tomonori Furukawa, Masaki Adachi, Michio Takahashi, Tamaki Mikami, Michito Kuribayashi, Ayako Osato, Daiki Tsushima, Manabu Saito, Shinya Ueno, Kazuhiko Nakamura

    Psychiatric genetics   31 ( 3 )   79 - 87   2021.2

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  • Effects of voluntary and forced exercises on motor function recovery in intracerebral hemorrhage rats.

    Chihiro Sato, Kunikazu Tanji, Shuji Shimoyama, Mitsuru Chiba, Misaki Mikami, Shuhei Koeda, Koshi Sumigawa, Kazuki Akahira, Junko Yamada

    Neuroreport   31 ( 2 )   189 - 196   2020.1

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  • Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2.

    Shimoyama S, Furukawa T, Ogata Y, Nikaido Y, Koga K, Sakamoto Y, Ueno S, Nakamura K

    PloS one   14 ( 9 )   e0222861 - e0222861   2019.9

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  • Phospholipase C-related inactive protein type-1 deficiency affects anesthetic electroencephalogram activity induced by propofol and etomidate in mice.

    Furukawa T, Nikaido Y, Shimoyama S, Ogata Y, Kushikata T, Hirota K, Kanematsu T, Hirata M, Ueno S

    Journal of anesthesia   33 ( 4 )   531 - 542   2019.8

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  • Anti-hypersensitive effect of angiotensin (1-7) on streptozotocin-induced diabetic neuropathic pain in mice.

    Yoshiki Ogata, Wataru Nemoto, Ryota Yamagata, Osamu Nakagawasai, Shuji Shimoyama, Tomonori Furukawa, Shinya Ueno, Koichi Tan-No

    European journal of pain (London, England)   23 ( 4 )   739 - 749   2019.4

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  • 〈一般演題抄録〉遺伝子<i>Tspo</i> の発現制御メカニズムの解明

    下山 修司, 古川 智範, 小潟 佳輝, 中村 和彦, 上野 伸哉

    弘前医学   69 ( 1-4 )   207   2019.3

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    CiNii Research

  • 遺伝子Tspoの発現制御メカニズムの解明

    下山 修司, 古川 智範, 小潟 佳輝, 中村 和彦, 上野 伸哉

    弘前医学   69 ( 1-4 )   207 - 207   2019.3

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  • Stimulating muscarinic M<sub>1</sub> receptors in the anterior cingulate cortex reduces mechanical hypersensitivity via GABAergic transmission in nerve injury rats.

    Koga K, Matsuzaki Y, Migita K, Shimoyama S, Eto F, Nakagawa T, Matsumoto T, Terada K, Mishima K, Furue H, Honda K

    Brain research   1704   187 - 195   2019.2

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  • 〈一般抄録演題〉パーキンソン病患者の末梢血単核球におけるオートファジーの変化

    三木 康生, 下山 修司, 早狩 亮, 今 智矢, 上野達哉 達哉, 丹治 邦和, 松宮 朋穂, 対馬 栄輝, 森 文秋, 冨山 誠彦, 若林 孝一

    弘前医学   69 ( 1-4 )   201   2019

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    CiNii Research

  • Alteration of autophagy-related proteins in peripheral blood mononuclear cells of patients with Parkinson's disease.

    Yasuo Miki, Shuji Shimoyama, Tomoya Kon, Tatsuya Ueno, Ryo Hayakari, Kunikazu Tanji, Tomoh Matsumiya, Eiki Tsushima, Fumiaki Mori, Koichi Wakabayashi, Masahiko Tomiyama

    Neurobiology of aging   63   33 - 43   2018.3

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  • Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex.

    Koga K, Shimoyama S, Yamada A, Furukawa T, Nikaido Y, Furue H, Nakamura K, Ueno S

    Molecular pain   14   174480691878347   2018.1

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  • Propofol Anesthesia Is Reduced in Phospholipase C-Related Inactive Protein Type-1 Knockout Mice

    Yoshikazu Nikaido, Tomonori Furukawa, Shuji Shimoyama, Junko Yamada, Keisuke Migita, Kohei Koga, Tetsuya Kushikata, Kazuyoshi Hirota, Takashi Kanematsu, Masato Hirata, Shinya Ueno

    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS   361 ( 3 )   367 - 374   2017.6

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    Web of Science

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  • Chronic diazepam administration increases the expression of Lcn2 in the CNS

    Tomonori Furukawa, Shuji Shimoyama, Yasuo Miki, Yoshikazu Nikaido, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi, Shinya Ueno

    Pharmacology Research and Perspectives   5 ( 1 )   e00283   2017.2

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  • 〈一般演題抄録〉うつ病モデルラットは内側前頭前野機能異常を起こす

    二階堂 義和, 古川 智範, 下山 修司, 古賀 浩平, 上野 伸哉

    弘前医学   67 ( 2-4 )   185   2017

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  • 〈一般演題抄録〉ジアゼパム長期投与マウスにおける脳内 Lcn2 発現および認知機能の解析

    古川 智範, 二階堂 義和, 下山 修司, 三木 康生, 古賀 浩平, 中村 和彦, 若林 孝一, 上野 伸哉

    弘前医学   68 ( 1 )   88   2017

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  • 〈一般演題抄録〉ジアゼパム長期投与マウス脳組織のトランスクリプトーム解析

    古川 智範, 下山 修司, 二階堂 義和, 古賀 浩平, 中村 和彦, 上野 伸哉

    弘前医学   67 ( 2-4 )   186   2017

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    CiNii Research

  • HSP90 Regulation of P2X7 Receptor Function Requires an Intact Cytoplasmic C-Terminus

    Keisuke Migita, Taku Ozaki, Shuji Shimoyama, Junko Yamada, Yoshikazu Nikaido, Tomonori Furukawa, Yuko Shiba, Terrance M. Egan, Shinya Ueno

    MOLECULAR PHARMACOLOGY   90 ( 2 )   116 - 126   2016.8

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  • GABA<sub>A</sub> 受容体応答の制御機構

    上野 伸哉, 古川 智範, 二階堂 義和, 下山 修司, 柴 祐子, 山田 順子

    弘前医学   66 ( 2-4 )   105 - 109   2016

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    CiNii Research

  • The Mycotoxin Patulin Decreases Expression of Density-Enhanced Phosphatase-1 by Down-Regulating PPAR<i>γ</i> in Human Colon Cancer Cells

    Katsuyama Akihiro, Konno Tomomi, Shimoyama Shuji, Kikuchi Hideaki

    The Tohoku Journal of Experimental Medicine   233 ( 4 )   265 - 274   2014

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    Web of Science

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    CiNii Research

  • Involvement of CREM in CYP1A1 induction through ligand-independent activation pathway of aryl hydrocarbon receptor in HepG2 cells

    Eriko Sasamori, Shuji Shimoyama, Shinichi Fukushige, Hideaki Kikuchi

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   478 ( 1 )   26 - 35   2008.10

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    Web of Science

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Review Papers

  • 多系統萎縮症モデルマウスにおける小脳シナプスオーガナイザー分子の減少

    今智矢, 下山修司, 丹治邦和, 若林孝一, 冨山誠彦

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   15th   2021

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    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Kind of work:Joint Work  

    J-GLOBAL

  • 抗不安薬ジアゼパムの長期使用による海馬神経機能への影響

    古川智範, 二階堂義和, 二階堂義和, 下山修司, 下山修司, 上野伸哉, 上野伸哉

    日本脳科学会プログラム・講演抄録集   47th   2020

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    J-GLOBAL

  • パーキンソン病患者の末梢血単核球におけるオートファジーの変化

    三木 康生, 下山 修司, 早狩 亮, 今 智矢, 上野 達哉, 丹治 邦和, 松宮 朋穂, 対馬 栄輝, 森 文秋, 冨山 誠彦, 若林 孝一

    弘前医学   69 ( 1-4 )   201 - 201   2019.3

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    Language:Japanese   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:弘前大学大学院医学研究科・弘前医学会   Kind of work:Joint Work  

  • GABAA受容体応答の制御機構

    上野伸哉,古川智範,二階堂義和,下山修司,柴祐子,山田順子

    弘前医学   66 ( 2-4 )   105 - 109   2016.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)   Publisher:弘前大学大学院医学研究科・弘前医学会   Kind of work:Joint Work  

Awards

  • 日本脳科学会奨励賞

    2017.10