Life Science / Psychiatry

Attempt to Develop Therapeutic Drug for Autism by Targeting IGF-1: Exploration of Small Compounds for IGF-1 Gene Expression

Nakamura, K; Shimoyama, S; Sakamoto, Y; Furukawa, T; Hasegawa, A; Shimizu, R; Kojima, H; Ueno, S

NEUROPSYCHOPHARMACOLOGY   48   128 - 128   2023.12

Qualitative and quantitative alterations of synaptotagmin 13 in synucleinopathies

Miki, Y; Tanaka, M; Shimoyama, S; Nakahara, A; Kakita, A; Wakabayashi, K

BRAIN PATHOLOGY   33   2023.9

Intranasal administration of trehalose reduces α-synuclein oligomers by accelerating aggregate formation in a mouse model of multiple system atrophy

Tanaka, M; Miki, Y; Mori, F; Furukawa, T; Shimoyama, S; Tatara, Y; Wakabayashi, K

BRAIN PATHOLOGY   33   2023.9

Effect of Ionizing Radiation on the Intercellular Network of Murine Cerebral Cortical Neurons

Masaru Yamaguchi, Takakiyo Tsujiguchi, Tomonori Furukawa, Shuji Shimoyama, Toshiya Nakamura, Yasushi Mariya and Junko Yamada

Radiation Environment and Medicine   12 ( 1 )   2023.2

Intraperitoneal Administration of Etizolam Improves Locomotor Function in Mice After Spinal Cord Injury

Kenya Saruta, Tatsuhiro Fukutoku, Gentaro Kumagai, Toshihide Nagaoki, Manami Tsukuda, Yohshiro Nitobe, Kanichiro Wada, Toru Asari, Taku Fujita, Isamu Sasaki, Yoshikazu Nikaido, Shuji Shimoyama, Shinya Ueno, Yasuyuki Ishibashi

Neurotrauma Reports   4 ( 1 )   2023.2

TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex.

Ryo Kawabata, Shuji Shimoyama, Shinya Ueno, Ikuko Yao, Akiko Arata, Kohei Koga

Scientific reports   13 ( 1 )   2960 - 2960   2023.2

Pathological substrate of memory impairment in multiple system atrophy.

Yasuo Miki, Kunikazu Tanji, Kana Shinnai, Makoto T Tanaka, Firat Altay, Sandrine C Foti, Catherine Strand, Takanori Sasaki, Tomoya Kon, Shuji Shimoyama, Tomonori Furukawa, Haruo Nishijima, Hiromi Yamazaki, Yasmine T Asi, Conceição Bettencourt, Zane Jaunmuktane, Mari Tada, Fumiaki Mori, Hiroki Mizukami, Masahiko Tomiyama, Hilal A Lashuel, Tammaryn Lashley, Akiyoshi Kakita, Helen Ling, Andrew J Lees, Janice L Holton, Thomas T Warner, Koichi Wakabayashi

Neuropathology and applied neurobiology   48 ( 7 )   e12844   2022.7

The role of neutrophil gelatinase-associated lipocalin and iron homeostasis in object recognition impairment in aged sepsis-survivor rats.

Nikaido Y, Midorikawa Y, Furukawa T, Shimoyama S, Takekawa D, Kitayama M, Ueno S, Kushikata T, Hirota K

Scientific reports   12 ( 1 )   249 - 249   2022.1

Impaired Cognitive Function and Hippocampal Changes Following Chronic Diazepam Treatment in Middle-Aged Mice.

Furukawa T, Nikaido Y, Shimoyama S, Masuyama N, Notoya A, Ueno S

Frontiers in aging neuroscience   13   777404 - 777404   2021.11

Copy number variations in Japanese children with autism spectrum disorder.

Yui Sakamoto, Shuji Shimoyama, Tomonori Furukawa, Masaki Adachi, Michio Takahashi, Tamaki Mikami, Michito Kuribayashi, Ayako Osato, Daiki Tsushima, Manabu Saito, Shinya Ueno, Kazuhiko Nakamura

Psychiatric genetics   31 ( 3 )   79 - 87   2021.2

Effects of voluntary and forced exercises on motor function recovery in intracerebral hemorrhage rats.

Chihiro Sato, Kunikazu Tanji, Shuji Shimoyama, Mitsuru Chiba, Misaki Mikami, Shuhei Koeda, Koshi Sumigawa, Kazuki Akahira, Junko Yamada

Neuroreport   31 ( 2 )   189 - 196   2020.1

Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2.

Shimoyama S, Furukawa T, Ogata Y, Nikaido Y, Koga K, Sakamoto Y, Ueno S, Nakamura K

PloS one   14 ( 9 )   e0222861 - e0222861   2019.9

Phospholipase C-related inactive protein type-1 deficiency affects anesthetic electroencephalogram activity induced by propofol and etomidate in mice.

Furukawa T, Nikaido Y, Shimoyama S, Ogata Y, Kushikata T, Hirota K, Kanematsu T, Hirata M, Ueno S

Journal of anesthesia   33 ( 4 )   531 - 542   2019.8

Anti-hypersensitive effect of angiotensin (1-7) on streptozotocin-induced diabetic neuropathic pain in mice.

Yoshiki Ogata, Wataru Nemoto, Ryota Yamagata, Osamu Nakagawasai, Shuji Shimoyama, Tomonori Furukawa, Shinya Ueno, Koichi Tan-No

European journal of pain (London, England)   23 ( 4 )   739 - 749   2019.4

遺伝子Tspoの発現制御メカニズムの解明

下山 修司, 古川 智範, 小潟 佳輝, 中村 和彦, 上野 伸哉

弘前医学   69 ( 1-4 )   207 - 207   2019.3

Stimulating muscarinic M₁ receptors in the anterior cingulate cortex reduces mechanical hypersensitivity via GABAergic transmission in nerve injury rats.

Koga K, Matsuzaki Y, Migita K, Shimoyama S, Eto F, Nakagawa T, Matsumoto T, Terada K, Mishima K, Furue H, Honda K

Brain research   1704   187 - 195   2019.2

Alteration of autophagy-related proteins in peripheral blood mononuclear cells of patients with Parkinson's disease.

Yasuo Miki, Shuji Shimoyama, Tomoya Kon, Tatsuya Ueno, Ryo Hayakari, Kunikazu Tanji, Tomoh Matsumiya, Eiki Tsushima, Fumiaki Mori, Koichi Wakabayashi, Masahiko Tomiyama

Neurobiology of aging   63   33 - 43   2018.3

Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex.

Koga K, Shimoyama S, Yamada A, Furukawa T, Nikaido Y, Furue H, Nakamura K, Ueno S

Molecular pain   14   174480691878347   2018.1

Propofol Anesthesia Is Reduced in Phospholipase C-Related Inactive Protein Type-1 Knockout Mice

Yoshikazu Nikaido, Tomonori Furukawa, Shuji Shimoyama, Junko Yamada, Keisuke Migita, Kohei Koga, Tetsuya Kushikata, Kazuyoshi Hirota, Takashi Kanematsu, Masato Hirata, Shinya Ueno

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS   361 ( 3 )   367 - 374   2017.6

Chronic diazepam administration increases the expression of Lcn2 in the CNS

Tomonori Furukawa, Shuji Shimoyama, Yasuo Miki, Yoshikazu Nikaido, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi, Shinya Ueno

Pharmacology Research and Perspectives   5 ( 1 )   e00283   2017.2

HSP90 Regulation of P2X7 Receptor Function Requires an Intact Cytoplasmic C-Terminus

Keisuke Migita, Taku Ozaki, Shuji Shimoyama, Junko Yamada, Yoshikazu Nikaido, Tomonori Furukawa, Yuko Shiba, Terrance M. Egan, Shinya Ueno

MOLECULAR PHARMACOLOGY   90 ( 2 )   116 - 126   2016.8

GABA_A 受容体応答の制御機構

上野 伸哉, 古川 智範, 二階堂 義和, 下山 修司, 柴 祐子, 山田 順子

弘前医学   66 ( 2-4 )   105 - 109   2016

Dephosphorylation of Sp1 at Ser-59 by Protein Phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole

Shuji Shimoyama, Shuya Kasai, Brigitte Kahn-Perles, Hideaki Kikuchi

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS   1839 ( 2 )   107 - 115   2014.3

The Mycotoxin Patulin Decreases Expression of Density-Enhanced Phosphatase-1 by Down-Regulating PPAR<i>γ</i> in Human Colon Cancer Cells

Katsuyama Akihiro, Konno Tomomi, Shimoyama Shuji, Kikuchi Hideaki

The Tohoku Journal of Experimental Medicine   233 ( 4 )   265 - 274   2014

Involvement of CREM in CYP1A1 induction through ligand-independent activation pathway of aryl hydrocarbon receptor in HepG2 cells

Eriko Sasamori, Shuji Shimoyama, Shinichi Fukushige, Hideaki Kikuchi

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   478 ( 1 )   26 - 35   2008.10

抗不安薬ジアゼパムの長期使用による海馬神経機能への影響

古川智範, 二階堂義和, 二階堂義和, 下山修司, 下山修司, 上野伸哉, 上野伸哉

日本脳科学会プログラム・講演抄録集   47th   26 - 26   2020

パーキンソン病患者の末梢血単核球におけるオートファジーの変化

三木 康生, 下山 修司, 早狩 亮, 今 智矢, 上野 達哉, 丹治 邦和, 松宮 朋穂, 対馬 栄輝, 森 文秋, 冨山 誠彦, 若林 孝一

弘前医学   69 ( 1-4 )   201 - 201   2019.3

GABA_A受容体応答の制御機構

上野伸哉,古川智範,二階堂義和,下山修司,柴祐子,山田順子

弘前医学   66 ( 2-4 )   105 - 109   2016.5