Life Science / Molecular biology

Life Science / Functional biochemistry

Abnormal α-synuclein binds to synaptotagmin 13, impairing extracellular vesicle release in synucleinopathies

Yasuo Miki, Shuji Shimoyama, Makoto T. Tanaka, Hanae Kushibiki, Asa Nakahara, Xiaopeng Wen, Masanori Hijioka, Tomoya Kon, Megha Murthy, Tomonori Furukawa, Conceição Bettencourt, Fumiaki Mori, Hiroki Mizukami, Shirushi Takahashi, Mari Tada, Yoshihisa Kitamura, Akiyoshi Kakita, Thomas T. Warner, Koichi Wakabayashi

Translational Neurodegeneration   14 ( 1 )   32   2025.6

Co-Expression of Tardive Dyskinesia and Drug-Induced Parkinsonism in Rats Chronically Treated With Haloperidol.

Iku Kinoshita, Haruo Nishijima, Takashi Nakamura, Tomoya Kon, Shuji Shimoyama, Hiroki Hikichi, Chieko Suzuki, Masahiko Tomiyama

Neuropsychopharmacology reports   45 ( 1 )   e12524   2025.3

Prepartum bumetanide treatment reverses altered neonatal social communication but nonspecifically reduces postpubertal social behavior in a mouse model of fragile X syndrome

Yui Sakamoto, Takeshi Takano, Shuji Shimoyama, Takeshi Hiramoto, Noboru Hiroi, Kazuhiko Nakamura

Genomic Psychiatry   2024.12

Sex-related differences in the effect of exercise on protein profiles of serum in mice

Furukawa Tomonori, Shimoyama Shuji, Kobayashi Aogi, Tatara Yota, Nikaido Yoshikazu, Ueno Shinya

Hirosaki Medical Journal   74 ( 1-4 )   40 - 51   2024.3

Benzodiazepine-induced cell growth inhibition via GABAA receptor- and TSPO-independent pathways

Shimoyama Shuji, Furukawa Tomonori, Ueno Shinya

Hirosaki Medical Journal   74 ( 1-4 )   52 - 60   2024.3

Intranasal administration of trehalose reduces α-synuclein oligomers and accelerates α-synuclein aggregation.

Makoto T Tanaka, Yasuo Miki, Fumiaki Mori, Tomoya Kon, Tomonori Furukawa, Shuji Shimoyama, Yota Tatara, Taku Ozaki, Conceição Bettencourt, Thomas T Warner, Koichi Wakabayashi

Brain communications   6 ( 4 )   fcae193   2024

Qualitative and quantitative alterations of synaptotagmin 13 in synucleinopathies

Miki, Y; Tanaka, M; Shimoyama, S; Nakahara, A; Kakita, A; Wakabayashi, K

BRAIN PATHOLOGY   33   2023.9

多系統萎縮症モデルマウスにおける小脳シナプス複合体分子の減少

岩澤 朋佳, 今 智矢, 下山 修司, 丹治 邦和, 西嶌 春生, 中村 崇志, 木下 郁, 鈴木 千恵子, 若林 孝一, 冨山 誠彦

弘前医学   73 ( 1-4 )   106 - 106   2023.3

多系統萎縮症モデルマウスにおける小脳シナプス複合体分子の減少

岩澤 朋佳, 今 智矢, 下山 修司, 丹治 邦和, 西嶌 春生, 中村 崇志, 木下 郁, 鈴木 千恵子, 若林 孝一, 冨山 誠彦

弘前医学   73 ( 1-4 )   106 - 106   2023.3

Effect of Ionizing Radiation on the Intercellular Network of Murine Cerebral Cortical Neurons

Masaru Yamaguchi, Takakiyo Tsujiguchi, Tomonori Furukawa, Shuji Shimoyama, Toshiya Nakamura, Yasushi Mariya and Junko Yamada

Radiation Environment and Medicine   12 ( 1 )   2023.2

Effect of Ionizing Radiation on the Intercellular Network of Murine Cerebral Cortical Neurons

Yamaguchi Masaru, Tsujiguchi Takakiyo, Furukawa Tomonori, Shimoyama Shuji, Nakamura Toshiya, Mariya Yasushi, Yamada Junko

Radiation Environment and Medicine   12 ( 1 )   65 - 73   2023.2

Intraperitoneal Administration of Etizolam Improves Locomotor Function in Mice After Spinal Cord Injury

Kenya Saruta, Tatsuhiro Fukutoku, Gentaro Kumagai, Toshihide Nagaoki, Manami Tsukuda, Yohshiro Nitobe, Kanichiro Wada, Toru Asari, Taku Fujita, Isamu Sasaki, Yoshikazu Nikaido, Shuji Shimoyama, Shinya Ueno, Yasuyuki Ishibashi

Neurotrauma Reports   4 ( 1 )   2023.2

TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex.

Ryo Kawabata, Shuji Shimoyama, Shinya Ueno, Ikuko Yao, Akiko Arata, Kohei Koga

Scientific reports   13 ( 1 )   2960 - 2960   2023.2

Intraperitoneal Administration of Etizolam Improves Locomotor Function in Mice After Spinal Cord Injury.

Kenya Saruta, Tatsuhiro Fukutoku, Gentaro Kumagai, Toshihide Nagaoki, Manami Tsukuda, Yohshiro Nitobe, Kanichiro Wada, Toru Asari, Taku Fujita, Isamu Sasaki, Yoshikazu Nikaido, Shuji Shimoyama, Shinya Ueno, Yasuyuki Ishibashi

Neurotrauma reports   4 ( 1 )   82 - 96   2023

Pathological substrate of memory impairment in multiple system atrophy.

Yasuo Miki, Kunikazu Tanji, Kana Shinnai, Makoto T Tanaka, Firat Altay, Sandrine C Foti, Catherine Strand, Takanori Sasaki, Tomoya Kon, Shuji Shimoyama, Tomonori Furukawa, Haruo Nishijima, Hiromi Yamazaki, Yasmine T Asi, Conceição Bettencourt, Zane Jaunmuktane, Mari Tada, Fumiaki Mori, Hiroki Mizukami, Masahiko Tomiyama, Hilal A Lashuel, Tammaryn Lashley, Akiyoshi Kakita, Helen Ling, Andrew J Lees, Janice L Holton, Thomas T Warner, Koichi Wakabayashi

Neuropathology and applied neurobiology   48 ( 7 )   e12844   2022.7

The role of neutrophil gelatinase-associated lipocalin and iron homeostasis in object recognition impairment in aged sepsis-survivor rats.

Yoshikazu Nikaido, Yoko Midorikawa, Tomonori Furukawa, Shuji Shimoyama, Daiki Takekawa, Masato Kitayama, Shinya Ueno, Tetsuya Kushikata, Kazuyoshi Hirota

Scientific reports   12 ( 1 )   249 - 249   2022.1

Copy number variations in Japanese children with autism spectrum disorder.

Yui Sakamoto, Shuji Shimoyama, Tomonori Furukawa, Masaki Adachi, Michio Takahashi, Tamaki Mikami, Michito Kuribayashi, Ayako Osato, Daiki Tsushima, Manabu Saito, Shinya Ueno, Kazuhiko Nakamura

Psychiatric genetics   31 ( 3 )   79 - 87   2021.6

Impaired Cognitive Function and Hippocampal Changes Following Chronic Diazepam Treatment in Middle-Aged Mice.

Tomonori Furukawa, Yoshikazu Nikaido, Shuji Shimoyama, Nozomu Masuyama, Ayaka Notoya, Shinya Ueno

Frontiers in aging neuroscience   13   777404 - 777404   2021

Effects of voluntary and forced exercises on motor function recovery in intracerebral hemorrhage rats.

Chihiro Sato, Kunikazu Tanji, Shuji Shimoyama, Mitsuru Chiba, Misaki Mikami, Shuhei Koeda, Koshi Sumigawa, Kazuki Akahira, Junko Yamada

Neuroreport   31 ( 2 )   189 - 196   2020.1

Phospholipase C-related inactive protein type-1 deficiency affects anesthetic electroencephalogram activity induced by propofol and etomidate in mice.

Tomonori Furukawa, Yoshikazu Nikaido, Shuji Shimoyama, Yoshiki Ogata, Tetsuya Kushikata, Kazuyoshi Hirota, Takashi Kanematsu, Masato Hirata, Shinya Ueno

Journal of anesthesia   33 ( 4 )   531 - 542   2019.8

Anti-hypersensitive effect of angiotensin (1-7) on streptozotocin-induced diabetic neuropathic pain in mice.

Yoshiki Ogata, Wataru Nemoto, Ryota Yamagata, Osamu Nakagawasai, Shuji Shimoyama, Tomonori Furukawa, Shinya Ueno, Koichi Tan-No

European journal of pain (London, England)   23 ( 4 )   739 - 749   2019.4

遺伝子Tspoの発現制御メカニズムの解明

下山 修司, 古川 智範, 小潟 佳輝, 中村 和彦, 上野 伸哉

弘前医学   69 ( 1-4 )   207 - 207   2019.3

Stimulating muscarinic M1 receptors in the anterior cingulate cortex reduces mechanical hypersensitivity via GABAergic transmission in nerve injury rats.

Kohei Koga, Yu Matsuzaki, Keisuke Migita, Shuji Shimoyama, Fumihiro Eto, Tatsuki Nakagawa, Taichi Matsumoto, Kazuki Terada, Kenichi Mishima, Hidemasa Furue, Kenji Honda

Brain research   1704   187 - 195   2019.2

Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2.

Shuji Shimoyama, Tomonori Furukawa, Yoshiki Ogata, Yoshikazu Nikaido, Kohei Koga, Yui Sakamoto, Shinya Ueno, Kazuhiko Nakamura

PloS one   14 ( 9 )   e0222861   2019

Alteration of autophagy-related proteins in peripheral blood mononuclear cells of patients with Parkinson's disease.

Yasuo Miki, Shuji Shimoyama, Tomoya Kon, Tatsuya Ueno, Ryo Hayakari, Kunikazu Tanji, Tomoh Matsumiya, Eiki Tsushima, Fumiaki Mori, Koichi Wakabayashi, Masahiko Tomiyama

Neurobiology of aging   63   33 - 43   2018.3

Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex.

Koga K, Shimoyama S, Yamada A, Furukawa T, Nikaido Y, Furue H, Nakamura K, Ueno S

Molecular pain   14   1744806918783478   2018.1

Propofol Anesthesia Is Reduced in Phospholipase C-Related Inactive Protein Type-1 Knockout Mice

Yoshikazu Nikaido, Tomonori Furukawa, Shuji Shimoyama, Junko Yamada, Keisuke Migita, Kohei Koga, Tetsuya Kushikata, Kazuyoshi Hirota, Takashi Kanematsu, Masato Hirata, Shinya Ueno

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS   361 ( 3 )   367 - 374   2017.6

Chronic diazepam administration increases the expression of Lcn2 in the CNS

Tomonori Furukawa, Shuji Shimoyama, Yasuo Miki, Yoshikazu Nikaido, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi, Shinya Ueno

Pharmacology Research and Perspectives   5 ( 1 )   e00283   2017.2

HSP90 Regulation of P2X7 Receptor Function Requires an Intact Cytoplasmic C-Terminus

Keisuke Migita, Taku Ozaki, Shuji Shimoyama, Junko Yamada, Yoshikazu Nikaido, Tomonori Furukawa, Yuko Shiba, Terrance M. Egan, Shinya Ueno

MOLECULAR PHARMACOLOGY   90 ( 2 )   116 - 126   2016.8

The Mycotoxin Patulin Decreases Expression of Density-Enhanced Phosphatase-1 by Down-Regulating PPAR gamma in Human Colon Cancer Cells

Akihiro Katsuyama, Tomomi Konno, Shuji Shimoyama, Hideaki Kikuchi

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE   233 ( 4 )   265 - 274   2014.8

Dephosphorylation of Sp1 at Ser-59 by Protein Phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole

Shuji Shimoyama, Shuya Kasai, Brigitte Kahn-Perles, Hideaki Kikuchi

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS   1839 ( 2 )   107 - 115   2014.2

Dephosphorylation of Sp1 at Ser-59 by protein phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole.

Shimoyama S, Kasai S, Kahn-Perlès B, Kikuchi H

Biochimica et biophysica acta   1839 ( 2 )   107 - 15   2014.2

Dephosphorylation of Sp1 at Ser-59 by protein phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole.

Shimoyama S, Kasai S, Kahn-Perlès B, Kikuchi H

Biochimica et biophysica acta   1839 ( 2 )   107 - 115   2014.2

Involvement of CREM in CYP1A1 induction through ligand-independent activation pathway of aryl hydrocarbon receptor in HepG2 cells

Eriko Sasamori, Shuji Shimoyama, Shinichi Fukushige, Hideaki Kikuchi

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   478 ( 1 )   26 - 35   2008.10

抗不安薬ジアゼパムの長期使用による海馬神経機能への影響

古川智範, 二階堂義和, 二階堂義和, 下山修司, 下山修司, 上野伸哉, 上野伸哉

日本脳科学会プログラム・講演抄録集   47th   26 - 26   2020

パーキンソン病患者の末梢血単核球におけるオートファジーの変化

三木 康生, 下山 修司, 早狩 亮, 今 智矢, 上野 達哉, 丹治 邦和, 松宮 朋穂, 対馬 栄輝, 森 文秋, 冨山 誠彦, 若林 孝一

弘前医学   69 ( 1-4 )   201 - 201   2019.3

GABA_A受容体応答の制御機構

上野伸哉,古川智範,二階堂義和,下山修司,柴祐子,山田順子

弘前医学   66 ( 2-4 )   105 - 109   2016.5