論文 - 下山 修司
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Cerebrospinal fluid HOMER1 and NPTX2 as candidate signatures in early-stage multiple system atrophy-parkinsonism.
Saki Hatakeyama, Yasuo Miki, Makoto Timon Tanaka, Eri Shibuya, Tatsuya Ueno, Shuji Shimoyama, Haruo Nishijima, Akira Arai, Chieko Suzuki, Masahiko Tomiyama, Akiyoshi Kakita, Koichi Wakabayashi
Journal of the neurological sciences 483 125840 - 125840 2026年02月
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Correlation between sleep problems and morning serum melatonin and ferritin levels in Japanese 5-year-old children with autism spectrum disorder
Terui, A; Saito, M; Kuki, A; Shimoyama, S; Sakamoto, Y; Yoshida, K; Osato, A; Nakamura, K
PSYCHIATRY AND CLINICAL NEUROSCIENCES REPORTS 5 ( 1 ) e70294 2026年02月
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Cerebrospinal fluid-driven extracellular vesicle as a potential diagnostic biomarker for multiple system atrophy
Shibuya, E; Miki, Y; Tanaka, MT; Ueno, T; Shimoyama, S; Tatara, Y; Nishijima, H; Arai, A; Suzuki, C; Mori, F; Wakabayashi, K; Tomiyama, M
JOURNAL OF THE NEUROLOGICAL SCIENCES 478 123738 2025年11月
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Type 2 diabetes alters quiescent pancreatic stellate cells to tumor-prone state
Hara, Y; Mizukami, H; Yamada, T; Shimoyama, S; Yamazaki, K; Sasaki, T; Wang, ZC; Kushibiki, H; Ryuzaki, M; Ogasawara, S; Tamba, H; Itaya, A; Kimura, N; Ishido, K; Ueno, S; Hakamada, K
JCI INSIGHT 10 ( 12 ) 2025年06月
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Abnormal α-synuclein binds to synaptotagmin 13, impairing extracellular vesicle release in synucleinopathies
Miki, Y; Shimoyama, S; Tanaka, MT; Kushibiki, H; Nakahara, A; Wen, XP; Hijioka, M; Kon, T; Murthy, M; Furukawa, T; Bettencourt, C; Mori, F; Mizukami, H; Takahashi, S; Tada, M; Kitamura, Y; Kakita, A; Warner, TT; Wakabayashi, K
TRANSLATIONAL NEURODEGENERATION 14 ( 1 ) 32 2025年06月
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Co-Expression of Tardive Dyskinesia and Drug-Induced Parkinsonism in Rats Chronically Treated With Haloperidol
Kinoshita, I; Nishijima, H; Nakamura, T; Kon, T; Shimoyama, S; Hikichi, H; Suzuki, C; Tomiyama, M
NEUROPSYCHOPHARMACOLOGY REPORTS 45 ( 1 ) e12524 2025年03月
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Prepartum bumetanide treatment reverses altered neonatal social communication but nonspecifically reduces postpubertal social behavior in a mouse model of fragile X syndrome
Yui Sakamoto, Takeshi Takano, Shuji Shimoyama, Takeshi Hiramoto, Noboru Hiroi, Kazuhiko Nakamura
Genomic Psychiatry 2024年12月
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Sex-related differences in the effect of exercise on protein profiles of serum in mice
Furukawa Tomonori, Shimoyama Shuji, Kobayashi Aogi, Tatara Yota, Nikaido Yoshikazu, Ueno Shinya
Hirosaki Medical Journal 74 ( 1-4 ) 40 - 51 2024年03月
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Benzodiazepine-induced cell growth inhibition via GABAA receptor- and TSPO-independent pathways
Shimoyama Shuji, Furukawa Tomonori, Ueno Shinya
Hirosaki Medical Journal 74 ( 1-4 ) 52 - 60 2024年03月
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Intranasal administration of trehalose reduces α-synuclein oligomers and accelerates α-synuclein aggregation
Tanaka, MT; Miki, Y; Mori, F; Kon, T; Furukawa, T; Shimoyama, S; Tatara, Y; Ozaki, T; Bettencourt, C; Warner, TT; Wakabayashi, K
BRAIN COMMUNICATIONS 6 ( 4 ) fcae193 2024年
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Benzodiazepin-induced cell growth inhibition via GABAA receptor- and TSPO-independent pathways
下山 修司, 古川 智範
Hirosaki Med J 74 52 - 60 2024年
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Qualitative and quantitative alterations of synaptotagmin 13 in synucleinopathies
Miki, Y; Tanaka, M; Shimoyama, S; Nakahara, A; Kakita, A; Wakabayashi, K
BRAIN PATHOLOGY 33 2023年09月
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Intranasal administration of trehalose reduces α-synuclein oligomers by accelerating aggregate formation in a mouse model of multiple system atrophy
Tanaka, M; Miki, Y; Mori, F; Furukawa, T; Shimoyama, S; Tatara, Y; Wakabayashi, K
BRAIN PATHOLOGY 33 2023年09月
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多系統萎縮症モデルマウスにおける小脳シナプス複合体分子の減少
岩澤 朋佳, 今 智矢, 下山 修司, 丹治 邦和, 西嶌 春生, 中村 崇志, 木下 郁, 鈴木 千恵子, 若林 孝一, 冨山 誠彦
弘前医学 73 ( 1-4 ) 106 - 106 2023年03月
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多系統萎縮症モデルマウスにおける小脳シナプス複合体分子の減少
岩澤 朋佳, 今 智矢, 下山 修司, 丹治 邦和, 西嶌 春生, 中村 崇志, 木下 郁, 鈴木 千恵子, 若林 孝一, 冨山 誠彦
弘前医学 73 ( 1-4 ) 106 - 106 2023年03月
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Effect of Ionizing Radiation on the Intercellular Network of Murine Cerebral Cortical Neurons
Masaru Yamaguchi, Takakiyo Tsujiguchi, Tomonori Furukawa, Shuji Shimoyama, Toshiya Nakamura, Yasushi Mariya and Junko Yamada
Radiation Environment and Medicine 12 ( 1 ) 2023年02月
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Effect of Ionizing Radiation on the Intercellular Network of Murine Cerebral Cortical Neurons
Yamaguchi Masaru, Tsujiguchi Takakiyo, Furukawa Tomonori, Shimoyama Shuji, Nakamura Toshiya, Mariya Yasushi, Yamada Junko
Radiation Environment and Medicine 12 ( 1 ) 65 - 73 2023年02月
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Intraperitoneal Administration of Etizolam Improves Locomotor Function in Mice After Spinal Cord Injury
Kenya Saruta, Tatsuhiro Fukutoku, Gentaro Kumagai, Toshihide Nagaoki, Manami Tsukuda, Yohshiro Nitobe, Kanichiro Wada, Toru Asari, Taku Fujita, Isamu Sasaki, Yoshikazu Nikaido, Shuji Shimoyama, Shinya Ueno, Yasuyuki Ishibashi
Neurotrauma Reports 4 ( 1 ) 2023年02月
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TRPA1 as a O<sub>2</sub> sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex
Kawabata, R; Shimoyama, S; Ueno, S; Yao, I; Arata, A; Koga, K
SCIENTIFIC REPORTS 13 ( 1 ) 2960 - 2960 2023年02月
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Intraperitoneal Administration of Etizolam Improves Locomotor Function in Mice After Spinal Cord Injury
Saruta, K; Fukutoku, T; Kumagai, G; Nagaoki, T; Tsukuda, M; Nitobe, Y; Wada, K; Asari, T; Fujita, T; Sasaki, I; Nikaido, Y; Shimoyama, S; Ueno, S; Ishibashi, Y
NEUROTRAUMA REPORTS 4 ( 1 ) 82 - 96 2023年
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Pathological substrate of memory impairment in multiple system atrophy
Miki, Y; Tanji, K; Shinnai, K; Tanaka, MT; Altay, F; Foti, SC; Strand, C; Sasaki, T; Kon, T; Shimoyama, S; Furukawa, T; Nishijima, H; Yamazaki, H; Asi, YT; Bettencourt, C; Jaunmuktane, Z; Tada, M; Mori, F; Mizukami, H; Tomiyama, M; Lashuel, HA; Lashley, T; Kakita, A; Ling, H; Lees, AJ; Holton, JL; Warner, TT; Wakabayashi, K
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 48 ( 7 ) e12844 2022年07月
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The role of neutrophil gelatinase-associated lipocalin and iron homeostasis in object recognition impairment in aged sepsis-survivor rats
Nikaido, Y; Midorikawa, Y; Furukawa, T; Shimoyama, S; Takekawa, D; Kitayama, M; Ueno, S; Kushikata, T; Hirota, K
SCIENTIFIC REPORTS 12 ( 1 ) 249 - 249 2022年01月
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Copy number variations in Japanese children with autism spectrum disorder
Sakamoto, Y; Shimoyama, S; Furukawa, T; Adachi, M; Takahashi, M; Mikami, T; Kuribayashi, M; Osato, A; Tsushima, D; Saito, M; Ueno, S; Nakamura, K
PSYCHIATRIC GENETICS 31 ( 3 ) 79 - 87 2021年06月
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Impaired Cognitive Function and Hippocampal Changes Following Chronic Diazepam Treatment in Middle-Aged Mice
Furukawa, T; Nikaido, Y; Shimoyama, S; Masuyama, N; Notoya, A; Ueno, S
FRONTIERS IN AGING NEUROSCIENCE 13 777404 - 777404 2021年
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Effects of voluntary and forced exercises on motor function recovery in intracerebral hemorrhage rats
Sato, C; Tanji, K; Shimoyama, S; Chiba, M; Mikami, M; Koeda, S; Sumigawa, K; Akahira, K; Yamada, J
NEUROREPORT 31 ( 2 ) 189 - 196 2020年01月
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Phospholipase C-related inactive protein type-1 deficiency affects anesthetic electroencephalogram activity induced by propofol and etomidate in mice
Furukawa, T; Nikaido, Y; Shimoyama, S; Ogata, Y; Kushikata, T; Hirota, K; Kanematsu, T; Hirata, M; Ueno, S
JOURNAL OF ANESTHESIA 33 ( 4 ) 531 - 542 2019年08月
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Anti-hypersensitive effect of angiotensin (1-7) on streptozotocin-induced diabetic neuropathic pain in mice.
Yoshiki Ogata, Wataru Nemoto, Ryota Yamagata, Osamu Nakagawasai, Shuji Shimoyama, Tomonori Furukawa, Shinya Ueno, Koichi Tan-No
European journal of pain (London, England) 23 ( 4 ) 739 - 749 2019年04月
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遺伝子Tspoの発現制御メカニズムの解明
下山 修司, 古川 智範, 小潟 佳輝, 中村 和彦, 上野 伸哉
弘前医学 69 ( 1-4 ) 207 - 207 2019年03月
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Stimulating muscarinic M<sub>1</sub> receptors in the anterior cingulate cortex reduces mechanical hypersensitivity via GABAergic transmission in nerve injury rats
Koga, K; Matsuzaki, Y; Migita, K; Shimoyama, S; Eto, F; Nakagawa, T; Matsumoto, T; Terada, K; Mishima, K; Furue, H; Honda, K
BRAIN RESEARCH 1704 187 - 195 2019年02月
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Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2
Shimoyama, S; Furukawa, T; Ogata, Y; Nikaido, Y; Koga, K; Sakamoto, Y; Ueno, S; Nakamura, K
PLOS ONE 14 ( 9 ) e0222861 2019年
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Alteration of autophagy-related proteins in peripheral blood mononuclear cells of patients with Parkinson's disease.
Miki Y, Shimoyama S, Kon T, Ueno T, Hayakari R, Tanji K, Matsumiya T, Tsushima E, Mori F, Wakabayashi K, Tomiyama M
Neurobiology of aging 63 33 - 43 2018年03月
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Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex.
Koga K, Shimoyama S, Yamada A, Furukawa T, Nikaido Y, Furue H, Nakamura K, Ueno S
Molecular pain 14 1744806918783478 2018年01月
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Propofol Anesthesia Is Reduced in Phospholipase C-Related Inactive Protein Type-1 Knockout Mice.
Nikaido Y, Furukawa T, Shimoyama S, Yamada J, Migita K, Koga K, Kushikata T, Hirota K, Kanematsu T, Hirata M, Ueno S
The Journal of pharmacology and experimental therapeutics 361 ( 3 ) 367 - 374 2017年06月
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Chronic diazepam administration increases the expression of Lcn2 in the CNS.
Furukawa T, Shimoyama S, Miki Y, Nikaido Y, Koga K, Nakamura K, Wakabayashi K, Ueno S
Pharmacology research & perspectives 5 ( 1 ) e00283 2017年02月
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HSP90 Regulation of P2X7 Receptor Function Requires an Intact Cytoplasmic C-Terminus.
Migita K, Ozaki T, Shimoyama S, Yamada J, Nikaido Y, Furukawa T, Shiba Y, Egan TM, Ueno S
Molecular pharmacology 90 ( 2 ) 116 - 126 2016年08月
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The mycotoxin patulin decreases expression of density-enhanced phosphatase-1 by down-regulating PPARγ in human colon cancer cells.
Katsuyama A, Konno T, Shimoyama S, Kikuchi H
The Tohoku journal of experimental medicine 233 ( 4 ) 265 - 274 2014年08月
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Dephosphorylation of Sp1 at Ser-59 by Protein Phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole
Shuji Shimoyama, Shuya Kasai, Brigitte Kahn-Perles, Hideaki Kikuchi
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1839 ( 2 ) 107 - 115 2014年02月
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Dephosphorylation of Sp1 at Ser-59 by protein phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole.
Shimoyama S, Kasai S, Kahn-Perlès B, Kikuchi H
Biochimica et biophysica acta 1839 ( 2 ) 107 - 15 2014年02月
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Dephosphorylation of Sp1 at Ser-59 by protein phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole.
Shimoyama S, Kasai S, Kahn-Perlès B, Kikuchi H
Biochimica et biophysica acta 1839 ( 2 ) 107 - 115 2014年02月
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Involvement of CREM in CYP1A1 induction through ligand-independent activation pathway of aryl hydrocarbon receptor in HepG2 cells.
Sasamori E, Shimoyama S, Fukushige S, Kikuchi H
Archives of biochemistry and biophysics 478 ( 1 ) 26 - 35 2008年10月