脂肪細胞分化制御因子fad104によるメラニン生成抑制機構の解明

西塚　誠

小柳財団報告書   2022.4

KCNMA1, a pore-forming α-subunit of BK channels, regulates insulin signalling in mature adipocytes.

Makoto Nishizuka, Wataru Horinouchi, Eri Yamada, Natsuki Ochiai, Shigehiro Osada, Masayoshi Imagawa

FEBS letters   590 ( 23 )   4372 - 4380   2016.12

Fad24, a Positive Regulator of Adipogenesis, Is Required for S Phase Re-entry of C2C12 Myoblasts Arrested in G0 Phase and Involved in p27(Kip1) Expression at the Protein Level.

Natsuki Ochiai, Makoto Nishizuka, Shigehiro Osada, Masayoshi Imagawa

Biological & pharmaceutical bulletin   39 ( 5 )   807 - 814   2016.5

FAD104, a Regulator of Adipogenesis and Osteogenesis, Interacts with the C-Terminal Region of STAT3 and Represses Malignant Transformation of Melanoma Cells.

Daiki Katoh, Makoto Nishizuka, Shigehiro Osada, Masayoshi Imagawa

Biological & pharmaceutical bulletin   39 ( 5 )   849 - 855   2016.5

Fad104, a positive regulator of adipocyte differentiation, suppresses invasion and metastasis of melanoma cells by inhibition of STAT3 activity.

Daiki Katoh, Makoto Nishizuka, Shigehiro Osada, Masayoshi Imagawa

PloS one   10 ( 2 )   e0117197 - e0117197   2015

KCNK10, a tandem pore domain potassium channel, is a regulator of mitotic clonal expansion during the early stage of adipocyte differentiation.

Makoto Nishizuka, Takahiro Hayashi, Mami Asano, Shigehiro Osada, Masayoshi Imagawa

International journal of molecular sciences   15 ( 12 )   22743 - 22756   2014.12

FAD104, a regulatory factor of adipogenesis, acts as a novel regulator of calvarial bone formation.

Keishi Kishimoto, Makoto Nishizuka, Daiki Katoh, Ayumi Kato, Shigehiro Osada, Masayoshi Imagawa

The Journal of biological chemistry   288 ( 44 )   31772 - 31783   2013.11

Targeted disruption of fad24, a regulator of adipogenesis, causes pre-implantation embryonic lethality due to the growth defect at the blastocyst stage.

Natsuki Ochiai, Makoto Nishizuka, Tomomi Miyamoto, Ichiro Miyoshi, Masahito Ikawa, Shigehiro Osada, Masayoshi Imagawa

Biochemical and biophysical research communications   438 ( 2 )   301 - 305   2013.8

Interactions of thyroid hormone receptor with Ku proteins and interleukin enhancer binding factor 3 modulate the promoter activity of thyroid-stimulating hormone alpha.

Masae Ohno, Mayu Fujita, Makoto Nishizuka, Shigehiro Osada, Masayoshi Imagawa

Biological & pharmaceutical bulletin   35 ( 3 )   380 - 384   2012

Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation.

Keishi Kishimoto, Makoto Nishizuka, Takashi Ueda, Kenji Kajita, Shinya Ugawa, Shoichi Shimada, Shigehiro Osada, Masayoshi Imagawa

Experimental cell research   317 ( 15 )   2110 - 2123   2011.9

Interleukin enhancer-binding factor 3 functions as a liver receptor homologue-1 co-activator in synergy with the nuclear receptor co-activators PRMT1 and PGC-1α.

Masae Ohno, Jun Komakine, Eiko Suzuki, Makoto Nishizuka, Shigehiro Osada, Masayoshi Imagawa

The Biochemical journal   437 ( 3 )   531 - 540   2011.8

Factor for adipocyte differentiation 158 gene disruption prevents the body weight gain and insulin resistance induced by a high-fat diet.

Takahiro Hayashi, Yuriko Nozaki, Makoto Nishizuka, Masahito Ikawa, Shigehiro Osada, Masayoshi Imagawa

Biological & pharmaceutical bulletin   34 ( 8 )   1257 - 1263   2011

RNA interference-mediated knockdown of the mouse gene encoding potassium channel subfamily K member 10 inhibits hormone-induced differentiation of 3T3-L1 preadipocytes.

Shuji Sato, Makoto Nishizuka, Mami Asano, Tsuyoshi Ohtake, Masayoshi Imagawa, Eiji Kobayashi

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology   157 ( 1 )   46 - 53   2010.9

Fad104, a positive regulator of adipogenesis, negatively regulates osteoblast differentiation.

Keishi Kishimoto, Ayumi Kato, Shigehiro Osada, Makoto Nishizuka, Masayoshi Imagawa

Biochemical and biophysical research communications   397 ( 2 )   187 - 191   2010.6

TC10-like/TC10betaLong regulates adipogenesis by controlling mitotic clonal expansion.

Atsuko Kawaji, Makoto Nishizuka, Shigehiro Osada, Masayoshi Imagawa

Biological & pharmaceutical bulletin   33 ( 3 )   404 - 409   2010

Repression of the promoter activity mediated by liver receptor homolog-1 through interaction with ku proteins.

Masae Ohno, Jun Komakine, Eiko Suzuki, Makoto Nishizuka, Shigehiro Osada, Masayoshi Imagawa

Biological & pharmaceutical bulletin   33 ( 5 )   784 - 791   2010

Gelsolin, an actin regulatory protein, is required for differentiation of mouse 3T3-L1 cells into adipocytes.

Atsuko Kawaji, Yuki Ohnaka, Shigehiro Osada, Makoto Nishizuka, Masayoshi Imagawa

Biological & pharmaceutical bulletin   33 ( 5 )   773 - 779   2010

Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.

Masae Ohno, Masaaki Kunimoto, Makoto Nishizuka, Shigehiro Osada, Masayoshi Imagawa

Biochemical and biophysical research communications   390 ( 3 )   738 - 742   2009.12

Fad24 causes hyperplasia in adipose tissue and improves glucose metabolism.

Yoshikazu Johmura, Kayoko Watanabe, Keishi Kishimoto, Takashi Ueda, Shoichi Shimada, Shigehiro Osada, Makoto Nishizuka, Masayoshi Imagawa

Biological & pharmaceutical bulletin   32 ( 10 )   1656 - 1664   2009.10

The role of C/EBPdelta in the early stages of adipogenesis.

Tomoaki Hishida, Makoto Nishizuka, Shigehiro Osada, Masayoshi Imagawa

Biochimie   91 ( 5 )   654 - 657   2009.5

Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration.

Makoto Nishizuka, Keishi Kishimoto, Ayumi Kato, Masahito Ikawa, Masaru Okabe, Ryuichiro Sato, Hiroyuki Niida, Makoto Nakanishi, Shigehiro Osada, Masayoshi Imagawa

Experimental cell research   315 ( 5 )   809 - 819   2009.3

A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion.

Tomoaki Hishida, Tsuyoshi Eguchi, Shigehiro Osada, Makoto Nishizuka, Masayoshi Imagawa

The FEBS journal   275 ( 22 )   5576 - 5588   2008.11

Wnt4 and Wnt5a promote adipocyte differentiation.

Makoto Nishizuka, Akiko Koyanagi, Shigehiro Osada, Masayoshi Imagawa

FEBS letters   582 ( 21-22 )   3201 - 3205   2008.9

FAD24, a regulator of adipogenesis, is required for the regulation of DNA replication in cell proliferation.

Yoshikazu Johmura, Shigehiro Osada, Makoto Nishizuka, Masayoshi Imagawa

Biological & pharmaceutical bulletin   31 ( 6 )   1092 - 1095   2008.6

Crucial roles of D-type cyclins in the early stage of adipocyte differentiation.

Tomoaki Hishida, Kumiko Naito, Shigehiro Osada, Makoto Nishizuka, Masayoshi Imagawa

Biochemical and biophysical research communications   370 ( 2 )   289 - 294   2008.5

FAD24, a regulator of adipogenesis and DNA replication, inhibits H-RAS-mediated transformation by repressing NF-kappaB activity.

Yoshikazu Johmura, Masanori Suzuki, Shigehiro Osada, Makoto Nishizuka, Masayoshi Imagawa

Biochemical and biophysical research communications   369 ( 2 )   464 - 470   2008.5

FAD24 acts in concert with histone acetyltransferase HBO1 to promote adipogenesis by controlling DNA replication.

Yoshikazu Johmura, Shigehiro Osada, Makoto Nishizuka, Masayoshi Imagawa

The Journal of biological chemistry   283 ( 4 )   2265 - 2274   2008.1

peg10, an imprinted gene, plays a crucial role in adipocyte differentiation.

Tomoaki Hishida, Kumiko Naito, Shigehiro Osada, Makoto Nishizuka, Masayoshi Imagawa

FEBS letters   581 ( 22 )   4272 - 4278   2007.9

SLC39A14, a LZT protein, is induced in adipogenesis and transports zinc.

Kei Tominaga, Takeshi Kagata, Yoshikazu Johmura, Tomoaki Hishida, Makoto Nishizuka, Masayoshi Imagawa

The FEBS journal   272 ( 7 )   1590 - 1599   2005.4

Design, synthesis, and biological activity of novel PPARgamma ligands based on rosiglitazone and 15d-PGJ2.

Shinya Usui, Takayoshi Suzuki, Yoshifumi Hattori, Kazuma Etoh, Hiroki Fujieda, Makoto Nishizuka, Masayoshi Imagawa, Hidehiko Nakagawa, Kohfuku Kohda, Naoki Miyata

Bioorganic & medicinal chemistry letters   15 ( 6 )   1547 - 1551   2005.3

Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation.

Kei Tominaga, Yoshikazu Johmura, Makoto Nishizuka, Masayoshi Imagawa

Journal of cell science   117 ( Pt 25 )   6217 - 6226   2004.12

The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis.

Kei Tominaga, Chiharu Kondo, Yoshikazu Johmura, Makoto Nishizuka, Masayoshi Imagawa

FEBS letters   577 ( 1-2 )   49 - 54   2004.11

Development of a Competitive Enzyme Immunoassay for Detection of Capacity of Chemicals to Bind Quail Estrogen Receptor alpha and beta

Maekawa S., Nishizuka M., Heitaku S., Kunimoto M., Nishikawa J., Ichikawa K., Shimada K., Imagawa M

Journal of Health Science   50 ( 1 )   25 - 32   2004.10

Evaluation of Ability of Chemicals to Bind Frog (Xenopus laevis) Estrogen Receptor by in Vitro Binding Assay

Suzuki E., Kunimoto M., Nishizuka M., Imagawa M.

Journal of Health Science   50 ( 6 )   685 - 688   2004.8

The novel gene fad158, having a transmembrane domain and leucine-rich repeat, stimulates adipocyte differentiation.

Kei Tominaga, Chiharu Kondo, Takeshi Kagata, Tomoaki Hishida, Makoto Nishizuka, Masayoshi Imagawa

The Journal of biological chemistry   279 ( 33 )   34840 - 34848   2004.8

Development of Standardized in Vitro Assay System for Estrogen Receptors and Species Specificity of Binding Ability of 4-Nonylphenol and p-Octylphenol.

Nishizuka M., Heitaku S., Maekawa S., Nishikawa J., Imagawa M.

Journal of Health Science   50 ( 5 )   511 - 517   2004.7

Isolation of Genes Regulated by Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) by Two-Dimensional Electrophoresis and Mass Spectrometer

Tsuchiya S., Arimoto E., Nishizuka M., Taguchi R., Imagawa M.

Journal of Health Science   50 ( 3 )   257 - 263   2004.2

Crucial role of TCL/TC10beta L, a subfamily of Rho GTPase, in adipocyte differentiation.

Makoto Nishizuka, Emi Arimoto, Tomoko Tsuchiya, Tsutomu Nishihara, Masayoshi Imagawa

The Journal of biological chemistry   278 ( 17 )   15279 - 15284   2003.4

脂肪細胞分化初期に発現が変動する遺伝子群の単離および機能解析

西塚　誠

2003.3

Isolation of up- or down-regulated genes in PPARgamma-expressing NIH-3T3 cells during differentiation into adipocytes.

Masaaki Okuno, Emi Arimoto, Makoto Nishizuka, Tsutomu Nishihara, Masayoshi Imagawa

FEBS letters   519 ( 1-3 )   108 - 112   2002.5

Induction of Bach1 and ARA70 gene expression at an early stage of adipocyte differentiation of mouse 3T3-L1 cells.

Makoto Nishizuka, Tomoko Tsuchiya, Tsutomu Nishihara, Masayoshi Imagawa

The Biochemical journal   361 ( Pt 3 )   629 - 633   2002.2

Expression of p68 RNA helicase is closely related to the early stage of adipocyte differentiation of mouse 3T3-L1 cells.

A Kitamura, M Nishizuka, K Tominaga, T Tsuchiya, T Nishihara, M Imagawa

Biochemical and biophysical research communications   287 ( 2 )   435 - 439   2001.9

RGS2 promotes adipocyte differentiation in the presence of ligand for peroxisome proliferator-activated receptor gamma.

M Nishizuka, K Honda, T Tsuchiya, T Nishihara, M Imagawa

The Journal of biological chemistry   276 ( 32 )   29625 - 29627   2001.8