論文 - 村井 康久
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VEXAS syndrome with eosinophilia and pathologically mimicking histiocytosis: a case report.
Murai Y, Watanabe R, Tsurumoto T, Kurotaki H, Tachita T, Takiyoshi N, Nagaki T, Kurosaka N, Yanagida R, Kikuchi R, Takasugi K, Zaimoku Y, Amenomori K, Ota S, Hasui K, Yamaguchi S, Hiraga H, Kanazawa H, Sakuraba H
Modern rheumatology case reports 9 ( 2 ) 2025年11月
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Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway.
Yasuhisa Murai, Ukhyun Jo, Junko Murai, Shinsaku Fukuda, Naoko Takebe, Yves Pommier
iScience 24 ( 10 ) 103173 - 103173 2021年10月
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SLFN11 inactivation induces proteotoxic stress and sensitizes cancer cells to ubiquitin activating enzyme inhibitor TAK-243.
Yasuhisa Murai, Ukhyun Jo, Junko Murai, Lisa Jenkins, Shar-Yin N Huang, Sirisha Chakka, Lu Chen, Ken Cheng, Shinsaku Fukuda, Naoko Takebe, Yves Pommier
Cancer research 81 ( 11 ) 3067 - 3078 2021年06月
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Ramucirumab+Paclitaxel療法中の進行胃癌出血に対しS-1併用放射線療法が有効であった1例
村井 康久, 五十嵐 昌平, 蓮井 桂介, 島谷 孝司, 花畑 憲洋, 金澤 浩介, 沼尾 宏, 棟方 正樹
青森県立中央病院医誌 61 ( 4 ) 149 - 154 2016年12月
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Ruxolitinib reverses systemic vasculitis driven by JAK2 V617F-mutated essential thrombocythemia: a case report.
Ashida Y, Ota S, Ishidoya N, Murai Y, Amenomori K, Hasui K, Kawaguchi S, Yamaguchi S, Hiraga H, Kamata K, Ichikawa H, Tomita H, Yu Z, Minakawa M, Sakuraba H
Frontiers in immunology 17 1781998 2026年
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Coexistence of plasmablastic lymphoma and adenocarcinoma in the stomach: a case report and literature review.
Maeda T, Takahata T, Goto S, Oyama T, Nakagawa S, Murai Y, Machida R, Ishidoya N, Sakamoto J, Iwamura H, Sakuraba H
International cancer conference journal 14 ( 2 ) 155 - 162 2025年04月
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Solitary Peutz-Jeghers polyp harboring a focus of high-grade dysplasia in the colon: a case report and literature review.
Maeda T, Yoshizawa T, Oyama T, Nakagawa S, Murai Y, Machida R, Ishidoya N, Sakamoto J, Iwamura H, Sakuraba H
Clinical journal of gastroenterology 18 ( 1 ) 89 - 94 2025年02月
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Colorectal Post-polypectomy Bleeding in Outpatient versus Inpatient Treatment: Propensity Score Matching Analysis.
Maeda T, Sakuraba H, Oyama T, Nakagawa S, Ota S, Murai Y, Machida R, Ishidoya N, Kikuchi H, Chinda D, Sakamoto J, Iwamura H
Journal of the Anus, Rectum and Colon 8 ( 3 ) 204 - 211 2024年07月
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Author Correction: ATR inhibition augments the efficacy of lurbinectedin in small-cell lung cancer
Christopher W Schultz, Yang Zhang, Rajaa Elmeskini, Astrid Zimmermann, Haiqing Fu, Yasuhisa Murai, Darawalee Wangsa, Suresh Kumar, Nobuyuki Takahashi, Devon Atkinson, Liton Kumar Saha, Chien-Fei Lee, Brian Elenbaas, Parth Desai, Robin Sebastian, Ajit Kumar Sharma, Melissa Abel, Brett Schroeder, Manan Krishnamurthy, Laurel L Bassel, Rajesh Kumar, Nitin Roper, Mirit Aladjem, Frank T Zenke, Zoe Weaver Ohler, Yves Pommier, Anish Thomas
EMBO Molecular Medicine 16 ( 3 ) 664 - 664 2024年02月
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A Logistic Regression Model for Predicting the Risk of Subsequent Surgery among Patients with Newly Diagnosed Crohn's Disease Using a Brute Force Method.
Ogasawara K, Hiraga H, Sasaki Y, Hiraga N, Higuchi N, Hasui K, Ota S, Maeda T, Murai Y, Tatsuta T, Kikuchi H, Chinda D, Mikami T, Matsuzaka M, Sakuraba H, Fukuda S
Diagnostics (Basel, Switzerland) 13 ( 23 ) 3587 - 3587 2023年12月
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Schlafen 11 (SLFN11) Kills Cancer Cells Undergoing Unscheduled Re-replication
Junko Murai, Michele Ceribelli, Haiqing Fu, Christophe E. Redon, Ukhyun Jo, Yasuhisa Murai, Mirit I. Aladjem, Craig J. Thomas, Yves Pommier
Molecular Cancer Therapeutics 22 ( 8 ) 985 - 995 2023年05月
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Vitamin A Promotes the Fusion of Autophagolysosomes and Prevents Excessive Inflammasome Activation in Dextran Sulfate Sodium-Induced Colitis.
Hiraga H, Chinda D, Maeda T, Murai Y, Ogasawara K, Muramoto R, Ota S, Hasui K, Sakuraba H, Ishiguro Y, Yoshida S, Asano K, Nakane A, Fukuda S
International journal of molecular sciences 24 ( 10 ) 8684 - 8684 2023年05月
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Evaluation of Crohn's Disease Small-Bowel Mucosal Healing Using Capsule Endoscopy and Usefulness of Leucine-Rich α2-Glycoprotein.
Hiraga H, Chinda D, Hasui K, Murai Y, Maeda T, Higuchi N, Ogasawara K, Kudo S, Sawada Y, Tatsuta T, Kikuchi H, Ebina M, Hiraga N, Mikami T, Sakuraba H, Fukuda S
Diagnostics (Basel, Switzerland) 13 ( 4 ) 626 - 626 2023年02月
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Bacterial exposure risk to the endoscopist's face while performing endoscopy.
Hoshi K, Kikuchi H, Narita K, Fukutoku Y, Asari T, Miyazawa K, Murai Y, Sawada Y, Tatsuta T, Hasui K, Hiraga H, Chinda D, Mikami T, Subsomwong P, Asano K, Nakane A, Fukuda S, Sakuraba H
DEN open 3 ( 1 ) e209 2023年01月
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Tacrolimus Up-regulates Expression of TGFβ Receptor Type II via ERK, Providing Protection Against Intestinal Epithelial Injury.
Satake M, Sakuraba H, Hiraga H, Yoshida S, Akemoto Y, Ota S, Murai Y, Hasui K, Kawaguchi S, Kikuchi H, Fukuda S
In vivo (Athens, Greece) 36 ( 4 ) 1684 - 1693 2022年07月
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Polygonum tinctorium leaves suppress sodium dextran sulfate-induced colitis through interleukin-10-related pathway.
Asari T, Kikuchi H, Kawaguchi S, Sakuraba H, Yoshida S, Akemoto Y, Maeda T, Shinji O, Murai Y, Higuchi N, Hoshi K, Fukutoku Y, Hiraga H, Sasaki K, Fukuda S
Biochemistry and biophysics reports 30 101272 - 101272 2022年07月
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Automated evaluation of colon capsule endoscopic severity of ulcerative colitis using ResNet50.
Higuchi N, Hiraga H, Sasaki Y, Hiraga N, Igarashi S, Hasui K, Ogasawara K, Maeda T, Murai Y, Tatsuta T, Kikuchi H, Chinda D, Mikami T, Matsuzaka M, Sakuraba H, Fukuda S
PloS one 17 ( 6 ) e0269728 2022年06月
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TOP1-DNA trapping by exatecan and combination therapy with ATR inhibitor.
Jo U, Murai Y, Agama KK, Sun Y, Saha LK, Yang X, Arakawa Y, Gayle S, Jones K, Paralkar V, Sundaram RK, Van Doorn J, Vasquez JC, Bindra RS, Choi WS, Pommier Y
Molecular cancer therapeutics 21 ( 7 ) 1090 - 1102 2022年04月
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Endoscopic and histopathologic features of Anti-PD-1-related collagenous colitis
Hidezumi Kikuchi, Hirotake Sakuraba, Yui Akemoto, Kazuhiro Hosoi, Yasuhisa Murai, Kentaro Hoshi, Yukari Fukutoku, Taka Asari, Yohei Sawada, Keisuke Hasui, Tetsuya Tatsuta, Hiroto Hiraga, Daisuke Chinda, Tatsuya Mikami, Shinsaku Fukuda
DEN Open 2 ( e92 ) 2022年01月
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Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexes.
Saha LK, Murai Y, Saha S, Jo U, Tsuda M, Takeda S, Pommier Y
Nucleic acids research 49 ( 18 ) 10493 - 10506 2021年09月
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Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11.
Jo U, Murai Y, Takebe N, Thomas A, Pommier Y
Cancers 13 ( 18 ) 4601 - 4601 2021年09月
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Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress and enhances the chemotherapeutic activity of widely used DNA damaging agents.
Ukhyun Jo, Ilya S Senatorov, Astrid Zimmermann, Liton Kumar Saha, Yasuhisa Murai, Se Hyun Kim, Vinodh N Rajapakse, Fathi Elloumi, Nobuyuki Takahashi, Christopher W Schultz, Anish Thomas, Frank T Zenke, Yves Pommier
Molecular cancer therapeutics 20 ( 8 ) 1431 - 1441 2021年05月
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SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.
Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M Miller Jenkins, Yves Pommier
Proceedings of the National Academy of Sciences of the United States of America 118 ( 6 ) e2015654118 - e2015654118 2021年02月
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Cyclosporine protects from intestinal epithelial injury by modulating butyrate uptake via upregulation of membrane monocarboxylate transporter 1 levels.
Ota S, Sakuraba H, Hiraga H, Yoshida S, Satake M, Akemoto Y, Tanaka N, Watanabe R, Takato M, Murai Y, Ueno K, Niioka T, Hayakari M, Ishiguro Y, Fukuda S
Biochemistry and biophysics reports 24 100811 - 100811 2020年12月
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Diagnostic approach for patients with unidentified fever according to the classical criteria of fever of unknown origin in the field of autoimmune disorders.
Rina Watanabe, Hirotake Sakuraba, Hiroto Hiraga, Dai Kishida, Shinji Ota, Keisuke Hasui, Hidezumi Kikuchi, Yui Akemoto, Nahoko Tanaka, Takato Maeda, Yasuhisa Murai, Shukuko Yoshida, Tetsuya Tatsuta, Manabu Sawaya, Daisuke Chinda, Tatsuya Mikami, Yoh Ishiguro, Shinsaku Fukuda
Immunological medicine 42 ( 4 ) 176 - 184 2019年12月
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Long-term maintenance of the mucosal healing induced by azacitidine therapy in a patient with intestinal Behçet's-like disease accompanied with myelodysplastic syndrome involving trisomy 8.
Nahoko Tanaka, Hirotake Sakuraba, Hiroto Hiraga, Ko Mayama, Hidezumi Kikuchi, Dai Kishida, Yui Akemoto, Keisuke Hasui, Shinji Ota, Rina Watanabe, Yasuhisa Murai, Takato Maeda, Kosuke Kamata, Tetsuya Tatsuta, Manabu Sawaya, Daisuke Chinda, Tatsuya Mikami, Kazufumi Yamagata, Yoh Ishiguro, Masanori Tanaka, Shinsaku Fukuda
Immunological medicine 42 ( 3 ) 135 - 141 2019年11月
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Long-term maintenance of the mucosal healing induced by azacitidine therapy in a patient with intestinal Behçet's-like disease accompanied with myelodysplastic syndrome involving trisomy 8.
Tanaka N, Sakuraba H, Hiraga H, Mayama K, Kikuchi H, Kishida D, Akemoto Y, Hasui K, Ota S, Watanabe R, Murai Y, Maeda T, Kamata K, Tatsuta T, Sawaya M, Chinda D, Mikami T, Yamagata K, Ishiguro Y, Tanaka M, Fukuda S
Immunological medicine 42 ( 3 ) 135 - 141 2019年09月
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A case of nivolumab-associated colitis, which relapsed after mucosal healing and was then successfully treated with mesalazine.
Hidezumi Kikuchi, Hirotake Sakuraba, Yui Akemoto, Yasuhisa Murai, Yukari Fukutoku, Taka Asari, Tetsuya Tatsuta, Keisuke Hasui, Hiroto Hiraga, Manabu Sawaya, Daisuke Chinda, Tatsuya Mikami, Masanori Tanaka, Shinsaku Fukuda
Immunological medicine 42 ( 1 ) 39 - 44 2019年03月
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Vitamin a Deficiency Impairs Host Resistance to Listeria Monocytogenes Infection Through Excessive Apoptosis of macrophages
弘前医学 69 ( 1-4 ) 163 - 171 2019年03月
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Vitamin A deficiency impairs host resistance to Listeria Monocytogenes infection through excessive apoptosis of macrophages
Nahoko Tanaka, Hiroto Hiraga, Hirotake Sakuraba, Yasuhisa Murai, Takato Maeda, Rina Watanabe, Shinji Ota, Yui Akemoto, Keisuke Hasui, Shukuko Yoshida, Krisana Asano, Akio Nakane, Shinsaku Fukuda
Hirosaki Medical Journal 69 163 - 171 2019年03月
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A case of nivolumab-associated colitis, which relapsed after mucosal healing and was then successfully treated with mesalazine.
Kikuchi H, Sakuraba H, Akemoto Y, Murai Y, Fukutoku Y, Asari T, Tatsuta T, Hasui K, Hiraga H, Sawaya M, Chinda D, Mikami T, Tanaka M, Fukuda S
Immunological medicine 42 ( 1 ) 39 - 44 2019年03月
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‹一般演題抄録›潰瘍性大腸炎の難治化における Schlafen11発現の臨床的意義
村井 康久, 櫻庭 裕丈, 蓮井 桂介, 平賀 寛人, 菊池 英純, 太田 真二, 澤田 洋平, 立田 哲也, 川口 章吾, 明本 由衣, 珍田 大輔, 黒瀬 顕, 三上 達也, 福田 眞作
弘前医学 75 ( 1 ) 79 2024年10月
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‹一般演題抄録›当科の潰瘍性大腸炎の5-アミノサリチル酸製剤の不耐症例の特徴について
福德 友香理, 蓮井 桂介, 平賀 寛人, 小笠原 公平, 珍田 大輔, 村井 康久, 澤田 洋平, 太田 真二, 明本 由衣, 福田 眞作, 速水 史郎, 櫻庭 裕丈, 立田 哲也, 菊池 英純
弘前医学 74 ( 1-4 ) 142 2024年03月
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成人発症IgA血管炎消化管病変評価における小腸カプセル内視鏡の有用性
平賀 寛人, 蓮井 桂介, 小笠原 公平, 村井 康久, 樋口 直樹, 澤田 洋平, 立田 哲也, 平賀 典子, 菊池 英純, 珍田 大輔, 海老名 麻美, 櫻庭 裕丈
日本小腸学会学術集会プログラム・抄録集 6 ( 0 ) 44 - 44 2022年