論文 - 原 裕太郎
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Type 2 diabetes alters quiescent pancreatic stellate cells to tumor-prone state.
Hara Y, Mizukami H, Yamada T, Shimoyama S, Yamazaki K, Sasaki T, Wang Z, Kushibiki H, Ryuzaki M, Ogasawara S, Tamba H, Itaya A, Kimura N, Ishido K, Ueno S, Hakamada K
JCI insight 10 ( 12 ) 2025年06月
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Dual epigenetic changes in diabetes mellitus-associated pancreatic ductal adenocarcinoma correlate with downregulation of E-cadherin and worsened prognosis.
Hara Y, Mizukami H, Yamazaki K, Yamada T, Igawa A, Takeuchi Y, Sasaki T, Kushibiki H, Murakami K, Kudoh K, Ishido K, Hakamada K
The journal of pathology. Clinical research 9 ( 5 ) 354 - 366 2023年09月
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Dual epigenetic changes in diabetes mellitus-associated pancreatic ductal adenocarcinoma correlate with downregulation of E-cadherin and worsened prognosis
Yutaro Hara , Hiroki Mizukami, Keisuke Yamazaki , Takahiro Yamada, Akiko Igawa , Yuki Takeuchi, Takanori Sasaki, Hanae Kushibiki, Kotaro Murakami, Kazuhiro Kudoh, Keinosuke Ishido, Kenichi Hakamada
The Journal of Pathology: Clinical Research 2023年07月
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Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma
Xuekai Pan, Hiroki Mizukami, Yutaro Hara , Takahiro Yamada , Keisuke Yamazaki , Kazuhiro Kudoh, Yuki Takeuchi, Takanori Sasaki, Hanae Kushibiki, Akiko Igawa, Kenichi Hakamada
2023年01月
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Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma.
Pan X, Mizukami H, Hara Y, Yamada T, Yamazaki K, Kudoh K, Takeuchi Y, Sasaki T, Kushibiki H, Igawa A, Hakamada K
Journal of diabetes investigation 14 ( 1 ) 132 - 144 2023年01月
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The diversity and abundance of gut microbiota are associated with the pain sensation threshold in the Japanese population
Yuki Takeuchi, Hiroki Mizukami, Kazuhiro Kudoh, Sho Osonoi, Takanori Sasaki, Hanae Kushibiki, Saori Ogasawara, Yutaro Hara, Akiko Igawa, Xuekai Pan, Takahiro Yamada, Keisuke Yamazaki, Tatsuya Mikami, Makoto Daimon, Soroku Yagihashi, Kenichi Hakamada, Shigeyuki Nakaji
2022年10月
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The diversity and abundance of gut microbiota are associated with the pain sensation threshold in the Japanese population.
Takeuchi Y, Mizukami H, Kudoh K, Osonoi S, Sasaki T, Kushibiki H, Ogasawara S, Hara Y, Igawa A, Pan X, Yamada T, Yamazaki K, Mikami T, Daimon M, Yagihashi S, Hakamada K, Nakaji S
Neurobiology of disease 173 105839 - 105839 2022年10月
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Development of a Biomarker-Based Scoring System Predicting Early Recurrence of Resectable Pancreatic Duct Adenocarcinoma.
Ishido K, Kimura N, Wakiya T, Nagase H, Hara Y, Kanda T, Fujita H, Hakamada K
Annals of surgical oncology 29 ( 2 ) 1281 - 1293 2022年02月
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Diabetes in Humans Activates Pancreatic Stellate Cells via RAGE in Pancreatic Ductal Adenocarcinoma
Chiaki Uchida, Hiroki Mizukami, Yutaro Hara, Takeshi Saito, Satoko Umetsu, Akiko Igawa , Sho Osonoi, Kazuhiro Kudoh, Yasuhiko Yamamoto, Hiroshi Yamamoto, Soroku Yagihashi, Kenichi Hakamada
2021年10月
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Diabetes in Humans Activates Pancreatic Stellate Cells via RAGE in Pancreatic Ductal Adenocarcinoma.
Uchida C, Mizukami H, Hara Y, Saito T, Umetsu S, Igawa A, Osonoi S, Kudoh K, Yamamoto Y, Yamamoto H, Yagihashi S, Hakamada K
International journal of molecular sciences 22 ( 21 ) 2021年10月
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Short-term outcomes of robotic-assisted laparoscopic versus laparoscopic lateral lymph node dissection for advanced lower rectal cancer.
Morohashi H, Sakamoto Y, Miura T, Kagiya T, Ogasawara K, Takahashi Y, Sato K, Hara Y, Ogasawara H, Hakamada K
Surgical endoscopy 35 ( 9 ) 5001 - 5008 2021年09月
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Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice.
Takahashi K, Mizukami H, Osonoi S, Ogasawara S, Hara Y, Kudoh K, Takeuchi Y, Sasaki T, Daimon M, Yagihashi S
Neurobiology of disease 155 105392 2021年07月
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[A Case of Descending Colon and Rectal Cancer with Acute Myeloid Leukemia Performed Robot‒Assisted Hartmann's Procedure].
Fujita H, Morohashi H, Sakamoto Y, Miura T, Sato K, Mitsuhashi Y, Umemura K, Ogasawara H, Hara Y, Kanda T, Kubota S, Hagiwara Y, Hakamada K
Gan to kagaku ryoho. Cancer & chemotherapy 48 ( 4 ) 599 - 601 2021年04月
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Organ/space infection is a common cause of high output stoma and outlet obstruction in diverting ileostomy.
Hara Y, Miura T, Sakamoto Y, Morohashi H, Nagase H, Hakamada K
BMC surgery 20 ( 1 ) 83 2020年04月
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[Gallbladder Cancer with Multiple Liver Metastases Completely Responding to Gemcitabile plus Cisplatin Chemotherapy-A Case Report].
Jin H, Ichisawa A, Hagiwara Y, Hara Y, Kimura T, Yonaiyama S, Yoshikawa T, Nakai M, Tokura T, Aoki K, Kawashima H, Toyoki Y, Endo M
Gan to kagaku ryoho. Cancer & chemotherapy 47 ( 2 ) 364 - 366 2020年02月
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フルニエ壊疽に対する肛門周囲広範デブリードマン後も排便機能を温存し得た1例
梅村 孝太郎, 三浦 卓也, 坂本 義之, 諸橋 一, 長瀬 勇人, 原 裕太郎, 袴田 健一
日本腹部救急医学会雑誌 40 ( 6 ) 787 - 790 2020年
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[Successful Treatment of Necrotizing Fasciitis Due to Ascending Colon Cancer-A Case Report].
Ichisawa A, Jin H, Hagiwara Y, Hara Y, Kimura T, Yonaiyama S, Yoshikawa T, Nakai M, Tokura T, Aoki K, Kawashima H, Toyoki Y, Endoh M
Gan to kagaku ryoho. Cancer & chemotherapy 46 ( 13 ) 2574 - 2576 2019年12月
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[A Case of Liver Recurrence of Choriocarcinoma and AFP-Producing Carcinoma of the Stomach Showing a Complete Histological Response after Chemotherapy].
Nakai M, Hara Y, Yonaiyama S, Jin H, Tokura T, Aoki K, Kawashima H, Toyoki Y, Endo M
Gan to kagaku ryoho. Cancer & chemotherapy 46 ( 1 ) 151 - 153 2019年01月
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〈一般演題抄録〉骨格筋量の推移からみた胸腔鏡下食道切除術の有用性の検討
原 裕太郎, 室谷 隆裕, 和嶋 直紀, 久保 寛仁, 吉田 枝里, 袴田 健一
弘前医学 69 ( 1 ) 2019年
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＜一般演題抄録＞多発肝転移を伴う切除不能膵癌に対してFOLFIRINOX療法が著効しconversion surgeryを施行し得た１例
小笠原 宏一, 高畑 武功, 佐藤 温, 袴田 健一, 石戸 圭之輔, 原 裕太郎, 赤石 隆信, 工藤 大輔, 木村 憲央, 米内山 真之介, 陳 豫, 斎藤 絢介
弘前医学 70 ( 1 ) 94 - 94 2019年
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[A Case of Advanced Gastric Cancer with Peritoneal Dissemination after Gastrectomy Effectively Treated with Combination Chemotherapy of Ramucirumab and Paclitaxel].
Muroya T, Wajima N, Kubo N, Yoshida E, Akaishi T, Umetsu S, Yoshida T, Wakasa Y, Sato K, Mitsuhashi Y, Umemura K, Ogasawara H, Hara Y, Hakamada K
Gan to kagaku ryoho. Cancer & chemotherapy 45 ( 13 ) 2066 - 2068 2018年12月
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[Outcomes of Total Mesorectal Excision and Lateral Lymph Node Dissection following Neoadjuvant Chemotherapy for Lower Rectal Cancer with Lateral Lymph Node Metastasis].
Morohashi H, Uchida C, Ogasawara H, Hara Y, Akaishi T, Yachi T, Wakasa Y, Mitsuhashi Y, Tsuruta S, Sato K, Yoshida T, Umetsu S, Hasebe T, Suto A, Hakamada K
Gan to kagaku ryoho. Cancer & chemotherapy 45 ( 13 ) 1803 - 1805 2018年12月
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[A Case of Perforated Gastric Cancer Treated with Curative Resection Following Conservative Medical Management and Chemotherapy].
Mitsuhashi Y, Muroya T, Wajima N, Kubo N, Yoshida E, Hara Y, Hakamada K
Gan to kagaku ryoho. Cancer & chemotherapy 45 ( 13 ) 1836 - 1838 2018年12月