日本臨床内分泌病理学会

a study group of the European Association for the Study of Diabetes

diabetic neuropathy study group of the European Association for the Study of Diabetes

American diabetic association

日本末梢神経学会

日本糖尿病学会

日本糖尿病合併症学会

日本臨床細胞学会

米国糖尿病学会

日本糖尿病学会

日本末梢神経学会

日本糖尿病動物・肥満学会

日本病理学会

日本病理学会東北支部

日本糖尿病動物・肥満学会

日本病理学会

糖尿病性神経障害の研究および診療の進歩 糖尿病性神経障害の概論および成因について

水上浩哉

糖尿病合併症   38 ( 1 )   102 - 105   2024.6

Identification of Ppy-lineage cells as a novel origin of pancreatic ductal adenocarcinoma.

Ofejiro Blessing Pereye, Yuko Nakagawa, Takashi Sato, Ayako Fukunaka, Shuhei Aoyama, Yuya Nishida, Wakana Mizutani, Nanami Kobayashi, Yohei Morishita, Tetsunari Oyama, Reika Kawabata-Iwakawa, Hirotaka Watada, Hiroki Mizukami, Akihisa Fukuda, Yoshio Fujitani

The Journal of pathology   263 ( 4-5 )   429 - 441   2024.6

特集 患者の将来を見据えた実践的糖尿病診療-脱 "血糖屋さん" のススメ 座談会 膵β細胞からみた日本人糖尿病患者の病態と最適な治療

白川 純, 水上 浩哉, 宮塚 健, 税所 芳史

内科   133 ( 5 )   1195 - 1202   2024.5

Upregulated expression of glucose transporter isoform 1 in invasive and metastatic extramammary Paget's disease.

Matsumoto M, Rokunohe D, Sasaki T, Matsuzaki Y, Nakano H, Mizukami H, Akasaka E, Sawamura D

27 ( 5 )   228   2024.5

Cellular localization of glucose transporters in seborrheic keratosisclinicopathological analysis

Matsumoto Mika, Rokunohe Daiki, Kogawa Kazuhito, Matsuzaki Yasushi, Sasaki Takanori, Nakano Hajime, Mizukami Hiroki, Akasaka Eijiro, Sawamura Daisuke

Hirosaki Medical Journal   74 ( 1-4 )   108 - 116   2024.3

Tryptophan metabolism and small fibre neuropathy: a correlation study.

Hanae Kushibiki, Hiroki Mizukami, Sho Osonoi, Yuki Takeuchi, Takanori Sasaki, Saori Ogasawara, Kanichiro Wada, Shin Midorikawa, Masaki Ryuzaki, Zhenchao Wang, Takahiro Yamada, Keisuke Yamazaki, Takefusa Tarusawa, Taiyo Tanba, Tatsuya Mikami, Atsushi Matsubara, Yasuyuki Ishibashi, Kenichi Hakamada, Shigeyuki Nakaji

Brain communications   6 ( 2 )   fcae103   2024.3

Diabetes can increase the prevalence of EBV infection and worsen the prognosis of nasopharyngeal carcinoma.

Midorikawa S, Mizukami H, Kudoh K, Takeuchi Y, Sasaki T, Kushibiki H, Wang Z, Itakura Y, Murakami K, Kudo N, Nagaki T, Wakasa T, Nakamura Y, Matsubara A

Pathology   56 ( 1 )   65 - 74   2024.2

Mitochondrial Reactive Oxygen Species, Insulin Resistance, and Nrf2-Mediated Oxidative Stress Response-Toward an Actionable Strategy for Anti-Aging.

Kasai S, Kokubu D, Mizukami H, Itoh K

Biomolecules   13 ( 10 )   2023.10

Serine supplementation: Is it a new option for the treatment of diabetic polyneuropathy?

Mizukami H

Journal of diabetes investigation   14 ( 10 )   1157 - 1159   2023.10

Dual epigenetic changes in diabetes mellitus-associated pancreatic ductal adenocarcinoma correlate with downregulation of E-cadherin and worsened prognosis.

1. Hara Y, Mizukami H, Yamazaki K, Yamada T, Igawa A, Takeuchi Y, Sasaki T, Kushibiki H, Murakami K, Kudoh K, Ishido K, Hakamada K.

J Pathol Clin Res.   9 ( 5 )   354 - 366.   2023.9

Endoscopic drainage with a metallic stent for obstructive jaundice caused by bile duct metastasis of breast cancer: A case report

Kenta Yoshida, Masaki Yokoyama, Yoshinori Hirao, Yuki Sato, Taro Saito, Yasushi Soma, Hiroki Mizukami, Shisaku Fukuda, Hirotake Sakuraba

CLINICAL CASE REPORTS   11 ( 6 )   e7543   2023.6

Dual epigenetic changes in diabetes mellitus-associated pancreatic ductal adenocarcinoma correlate with downregulation of E-cadherin and worsened prognosis

Yutaro Hara, Hiroki Mizukami, Keisuke Yamazaki, Takahiro Yamada, Akiko Igawa, Yuki Takeuchi, Takanori Sasaki, Hanae Kushibiki, Kotaro Murakami, Kazuhiro Kudoh, Keinosuke Ishido, Kenichi Hakamada

JOURNAL OF PATHOLOGY CLINICAL RESEARCH   9 ( 5 )   354 - 366   2023.5

Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma.

Pan X, Mizukami H, Hara Y, Yamada T, Yamazaki K, Kudoh K, Takeuchi Y, Sasaki T, Kushibiki H, Igawa A, Hakamada K.

J Diabetes Investig.   14 ( 1 )   132 - 144   2023.1

Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma

Xuekai Pan, Hiroki Mizukami, Yutaro Hara, Takahiro Yamada, Keisuke Yamazaki, Kazuhiro Kudoh, Yuki Takeuchi, Takanori Sasaki, Hanae Kushibiki, Akiko Igawa, Kenichi Hakamada

JOURNAL OF DIABETES INVESTIGATION   14 ( 1 )   132 - 144   2023.1

Pathological substrate of memory impairment in multiple system atrophy.

Miki Y, Tanji K, Shinnai K, Tanaka MT, Altay F, Foti SC, Strand C, Sasaki T, Kon T, Shimoyama S, Furukawa T, Nishijima H, Yamazaki H, Asi YT, Bettencourt C, Jaunmuktane Z, Tada M, Mori F, Mizukami H, Tomiyama M, Lashuel HA, Lashley T, Kakita A, Ling H, Lees AJ, Holton JL, Warner TT, Wakabayashi K.

Neuropathol Appl Neurobiol.   48 ( 7 )   e12844   2022.12

Correlation of magnetic resonance images with neuropathology of irreversible metronidazole-induced encephalopathy: an autopsy case report

Yasuo Miki, Yuki Takeuchi, Shingo Murasawa, Shinobu Takayasu, Fumiyasu Tsushima, Shingo Kakeda, Hiroki Mizukami, Koichi Wakabayashi

BMC NEUROLOGY   22 ( 1 )   485   2022.12

RAGE activation in macrophages and development of experimental diabetic polyneuropathy

Sho Osonoi, Hiroki Mizukami, Yuki Takeuchi, Hikari Sugawa, Saori Ogasawara, Shizuka Takaku, Takanori Sasaki, Kazuhiro Kudoh, Koichi Ito, Kazunori Sango, Ryoji Nagai, Yasuhiko Yamamoto, Makoto Daimon, Hiroshi Yamamoto, Soroku Yagihashi

JCI INSIGHT   7 ( 23 )   2022.12

Pathological substrate of memory impairment in multiple system atrophy

Yasuo Miki, Kunikazu Tanji, Kana Shinnai, Makoto T. Tanaka, Firat Altay, Sandrine C. Foti, Catherine Strand, Takanori Sasaki, Tomoya Kon, Shuji Shimoyama, Tomonori Furukawa, Haruo Nishijima, Hiromi Yamazaki, Yasmine T. Asi, Conceicao Bettencourt, Zane Jaunmuktane, Mari Tada, Fumiaki Mori, Hiroki Mizukami, Masahiko Tomiyama, Hilal A. Lashuel, Tammaryn Lashley, Akiyoshi Kakita, Helen Ling, Andrew J. Lees, Janice L. Holton, Thomas T. Warner, Koichi Wakabayashi

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY   48 ( 7 )   e12844   2022.12

The diversity and abundance of gut microbiota are associated with the pain sensation threshold in the Japanese population.

Takeuchi Y, Mizukami H, Kudoh K, Osonoi S, Sasaki T, Kushibiki H, Ogasawara S, Hara Y, Igawa A, Pan X, Yamada T, Yamazaki K, Mikami T, Daimon M, Yagihashi S, Hakamada K, Nakaji S.

Neurobiol Dis.   173   105839.   2022.10

Perivascular infiltration reflects subclinical lymph node metastasis in invasive lobular carcinoma.

Igawa A, Mizukami H, Kudoh K, Takeuchi Y, Sasaki T, Pan X, Hakamada K.

Virchows Arch.   481 ( 4 )   533 - 543   2022.10

Perivascular infiltration reflects subclinical lymph node metastasis in invasive lobular carcinoma

Akiko Igawa, Hiroki Mizukami, Kazuhiro Kudoh, Yuki Takeuchi, Takanori Sasaki, Xuekai Pan, Kenichi Hakamada

VIRCHOWS ARCHIV   481 ( 4 )   533 - 543   2022.10

The diversity and abundance of gut microbiota are associated with the pain sensation threshold in the Japanese population

Yuki Takeuchi, Hiroki Mizukami, Kazuhiro Kudoh, Sho Osonoi, Takanori Sasaki, Hanae Kushibiki, Saori Ogasawara, Yutaro Hara, Akiko Igawa, Xuekai Pan, Takahiro Yamada, Keisuke Yamazaki, Tatsuya Mikami, Makoto Daimon, Soroku Yagihashi, Kenichi Hakamada, Shigeyuki Nakaji

NEUROBIOLOGY OF DISEASE   173   105839   2022.10

Protocol to image and analyze the morphology of mouse peripheral nerves using transmission electron microscopy.

Hiromi Nakai-Shimoda, Tatsuhito Himeno, Mikio Motegi, Norio Ozeki, Rieko Inoue, Tomohide Hayami, Emiri Miura-Yura, Yuichiro Yamada, Yoshiaki Morishita, Shin Tsunekawa, Yoshiro Kato, Yusuke Seino, Masaki Kondo, Keiko Naruse, Koichi Kato, Hiroki Mizukami, Jiro Nakamura, Hideki Kamiya

STAR protocols   3 ( 3 )   101591 - 101591   2022.9

Protocol to image and analyze the morphology of mouse peripheral nerves using transmission electron microscopy.

Nakai-Shimoda H, Himeno T, Motegi M, Ozeki N, Inoue R, Hayami T, Miura-Yura E, Yamada Y, Morishita Y, Tsunekawa S, Kato Y, Seino Y, Kondo M, Naruse K, Kato K, Mizukami H, Nakamura J, Kamiya H.

STAR Protoc   3 ( 3 )   101591   2022.8

Cumulative autophagy insufficiency in mice leads to progression of β-cell failure.

Suzuki L, Miyatsuka T, Himuro M, Wakabayashi Y, Osonoi S, Miura M, Katahira T, Fujitani Y, Iida H, Mizukami H, Nishida Y, Watada H.

Biochem Biophys Res Commun.   611   38 - 45   2022.6

糖尿病性神経障害UPDATE:基礎と臨床の融合

水上浩哉，遲野井祥

糖尿病合併症   36   258 - 261   2022.6

Changes in Oral and Intestinal Bacterial Flora Associated with Pain Thresholds

Kazuhiro Kudoh, Yuki Takeuchi, Sho Osonoi, Takanori Sasaki, Saori Ogasawara, Soroku Yagihashi, Hiroki Mizukami

DIABETES   71   2022.6

Proinflammatory Macrophage Impairs Retrograde Axonal Transport via Inflammation and Insulin Resistance in Sensory Neurons

Sho Osonoi, Hiroki Mizukami, Saori Ogasawara, Kazuhiro Kudoh, Makoto Daimon, Soroku Yagihashi

DIABETES   71   2022.6

Partial Pancreatectomy Increased alpha-Cell Volume Density, but Not Compensated beta-Cell Volume in Japanese Subjects

Yuki Takeuchi, Hiroki Mizukami, Sho Osonoi, Kazuhiro Kudoh, Takanori Sasaki, Soroku Yagihashi

DIABETES   71   2022.6

Metabolic Remodeling in Pancreatic Beta Cells in Japanese Patients with Type 2 Diabetes

Rimi Izumihara, Hiroshi Nomoto, Koki Chiba, Hiraku Kameda, Kyuyong Cho, Akinobu Nakamura, Hideaki Miyoshi, Hiroki Mizukami, Tatsuya Atsumi

DIABETES   71   2022.6

Cumulative autophagy insufficiency in mice leads to progression of beta-cell failure

Luka Suzuki, Takeshi Miyatsuka, Miwa Himuro, Yuka Wakabayashi, Sho Osonoi, Masaki Miura, Takehiro Katahira, Yoshio Fujitani, Hitoshi Iida, Hiroki Mizukami, Yuya Nishida, Hirotaka Watada

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   611   38 - 45   2022.6

SINGLE-CELL RNA SEQUENCING REVEALS HETEROGENEITY AND A RARE POPULATION OF PANCREATIC STELLATE CELLS: TYPE 2 DIABETES INDUCES PANCREATIC STELLATE CELLS TO BECOME CANCER-ASSOCIATED FIBROBLAST-LIKE CAUSING PANCREATIC STELLATE STEM CELL LOSS

Yutaro Hara, Hiroki Mizukami, Takahiro Yamada, Keisuke Yamazaki, Norihisa Kimura, Keinosuke Ishido, Kenichi Hakamada

GASTROENTEROLOGY   162 ( 7 )   S242 - S242   2022.5

Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage.

Liu J, Kasai S, Tatara Y, Yamazaki H, Mimura J, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Tanji K, Wakabayashi K, Maeda H, Mizukami H, Shinkai Y, Kumagai Y, Tomita H, Itoh K.

Int J Mol Sci.   23 ( 6 )   3201   2022.3

Diversity of pathophysiology in type 2 diabetes shown by islet pathology

Hiroki Mizukami, Kazuhiro Kudoh

JOURNAL OF DIABETES INVESTIGATION   13 ( 1 )   6 - 13   2022.1

Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves

Hiromi Nakai-Shimoda, Tatsuhito Himeno, Tetsuji Okawa, Emiri Miura-Yura, Sachiko Sasajima, Makoto Kato, Yuichiro Yamada, Yoshiaki Morishita, Shin Tsunekawa, Yoshiro Kato, Yusuke Seino, Rieko Inoue, Masaki Kondo, Susumu Seino, Keiko Naruse, Koichi Kato, Hiroki Mizukami, Jiro Nakamura, Hideki Kamiya

ISCIENCE   25 ( 1 )   103609   2022.1

Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves.

Nakai-Shimoda H, Himeno T, Okawa T, Miura-Yura E, Sasajima S, Kato M, Yamada Y, Morishita Y, Tsunekawa S, Kato Y, Seino Y, Inoue R, Kondo M, Seino S, Naruse K, Kato K, Mizukami H, Nakamura J, Kamiya H.

iScience.   25 ( 1 )   103609   2021.12

A case of dermatofibrosarcoma protuberans with neurofibromatous change.

2021 ( 11 )   rjab472   2021.12

Islet microangiopathy and augmented β-cell loss in Japanese non-obese type 2 diabetes patients who died of acute myocardial infarction.

4. Takahashi K, Mizukami H, Osonoi S, Takeuchi Y, Kudoh K, Sasaki T, Daimon M, Yagihashi S.

J Diabetes Investig.   12 ( 12 )   2149 - 2161   2021.12

A case of dermatofibrosarcoma protuberans with neurofibromatous change

Kazuhiro Kudoh, Chieko Itabashi, Eiichi Arai, Shusa Ohshika, Hiroki Mizukami

JOURNAL OF SURGICAL CASE REPORTS   2021 ( 12 )   rjab472   2021.12

Diabetes in Humans Activates Pancreatic Stellate Cells via RAGE in Pancreatic Ductal Adenocarcinoma

Chiaki Uchida, Hiroki Mizukami, Yutaro Hara, Takeshi Saito, Satoko Umetsu, Akiko Igawa, Sho Osonoi, Kazuhiro Kudoh, Yasuhiko Yamamoto, Hiroshi Yamamoto, Soroku Yagihashi, Kenichi Hakamada

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   22 ( 21 )   2021.11

Diabetes in Humans Activates Pancreatic Stellate Cells via RAGE in Pancreatic Ductal Adenocarcinoma.

Uchida C, Mizukami H, Hara Y, Saito T, Umetsu S, Igawa A, Osonoi S, Kudoh K, Yamamoto Y, Yamamoto H, Yagihashi S, Hakamada K.

Int J Mol Sci.   22 ( 21 )   11716   2021.10

Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice

Takahashi K, Mizukami H, Osonoi S, Ogasawara S, Hara Y, Kudoh K, Takeuchi Y, Sasaki T, Daimon M, Yagihashi S

Neurobiol Dis.   155   105392   2021.7

MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis.

Diabetes   70 ( 7 )   1519 - 1535   2021.7

Detection of nerve enlargement with ultrasound and correlation with skin biopsy findings in painful sensory neuropathy associated with Sjogren's syndrome

Takeshi Yoshida, Hiroyuki Nodera, Yoshitaka Kumon, Saeko Osanai, Yuishin Izumi, Hiroki Mizukami

MODERN RHEUMATOLOGY   31 ( 4 )   849 - 855   2021.7

MEK/ERK Signaling in beta-Cells Bifunctionally Regulates beta-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis

Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Naoki Kobayashi, Sho Osonoi, Seiichi Takemiya, Hiroshi Kobayashi, Hirotsugu Suwanai, Yuichi Morimoto, Kotaro Soeda, Jun Adachi, Masafumi Muratani, Jean Charron, Hiroki Mizukami, Noriko Takahashi, Kohjiro Ueki

DIABETES   70 ( 7 )   1519 - 1535   2021.7

Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice

Kazuhisa Takahashi, Hiroki Mizukami, Sho Osonoi, Saori Ogasawara, Yutaro Hara, Kazuhiro Kudoh, Yuki Takeuchi, Takanori Sasaki, Makoto Daimon, Soroku Yagihashi

NEUROBIOLOGY OF DISEASE   155   105392   2021.7

Diabetes Activates Pancreatic Stellate Cells through RAGE Signaling in Pancreatic Ductal Adenocarcinoma

Chiaki Uchida, Hiroki Mizukami, Kazuhiro Kudo, Yasuhiko Yamamoto

DIABETES   70   2021.6

RAGE-Dependent Macrophage Activation Aggravates Retrograde Axonal Transport via Attenuated Insulin Signaling of Peripheral Nerves in Experimental Diabetic Polyneuropathy

Sho Osonoi, Hiroki Mizukami, Kazuhiro Kudo, Yasuhiko Yamamoto

DIABETES   70   2021.6

Islet microangiopathy and augmented beta-cell loss in Japanese non-obese type 2 diabetes patients who died of acute myocardial infarction

Kazuhisa Takahashi, Hiroki Mizukami, Sho Osonoi, Yuki Takeuchi, Kazuhiro Kudoh, Takanori Sasaki, Makoto Daimon, Soroku Yagihashi

JOURNAL OF DIABETES INVESTIGATION   12 ( 12 )   2149 - 2161   2021.5

Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice.

1. Nakamura T, Nampei M, Murase T, Satoh E, Akari S, Katoh N, Mizukami H.

Nutr Diabetes   11 ( 1 )   12   2021.4

Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice

Takashi Nakamura, Mai Nampei, Takayo Murase, Etsuko Satoh, Seigo Akari, Noriaki Katoh, Hiroki Mizukami

NUTRITION & DIABETES   11 ( 1 )   12   2021.4

Collateral Glucose-Utlizing Pathwaya in Diabetic Polyneuropathy

Hiroki Mizukami, Sho Osonoi

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   22 ( 1 )   2020.12

Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population.

Osonoi S, Mizukami H, Itabashi C, Wada K, Kudoh K, Igawa A, Ogasawara S, Ishibashi Y, Daimon M, Yagihashi S, Nakaji S.

Int J Mol Sci.   21 ( 21 )   8306   2020.11

Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population

Sho Osonoi, Hiroki Mizukami, Chieko Itabashi, Kanichiro Wada, Kazuhiro Kudoh, Akiko Igawa, Saori Ogasawara, Yasuyuki Ishibashi, Makoto Daimon, Soroku Yagihashi, Shigeyuki Nakaji

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   21 ( 21 )   2020.11

Detection of nerve enlargement with ultrasound and correlation with skin biopsy findings in painful sensory neuropathy associated with Sjögren's syndrome.

Yoshida T, Nodera H, Kumon Y, Osanai S, Izumi Y, Mizukami H.

Mod Rheumatol.   1 - 7   2020.10

Role of glucosamine in development of diabetic neuropathy independent of the aldose reductase pathway.

Mizukami H, Osonoi S, Takaku S, Yamagishi SI, Ogasawara S, Sango K, Chung S, Yagihashi S.

Brain Commun.   2 ( 2 )   fcaa168   2020.10

Lipopolysaccharide-binding protein is a distinctive biomarker of abnormal pain threshold in the general Japanese population

Kazuhiro Kudoh, Hiroki Mizukami, Chieko Itabashi, Nobuo Fuke, Sho Osonoi, Yuki Takeuchi, Kanichiro Wada, Akiko Igawa, Saori Ogasawara, Yasuyuki Ishibashi, Kenichi Hakamada, Soroku Yagihashi, Shigeyuki Nakaji

BMJ OPEN DIABETES RESEARCH & CARE   8 ( 1 )   2020.10

糖尿病性神経障害の病期と病態

遅野井　祥、水上浩哉

糖尿病合併症   34 ( 2 )   262 - 264   2020.7

Beneficial effects of combination therapy of canagliflozin and teneligliptin on diabetic polyneuropathy and ?-cell volume density in spontaneously type 2 diabetic Goto-Kakizaki rats

Danyang Guo, Hiroki Mizukami, Sho Osonoi, Kazuhisa Takahashi, Saori Ogasawara, Kazuhiro Kudo, Takanori Sasaki, Soroku Yagihashi

METABOLISM-CLINICAL AND EXPERIMENTAL   107   154232   2020.6

Activated Xanthine Oxidase in Serum Is a Potent Therapeutic Target for Experimental Diabetic Polyneuropathy

Hiroshi Ichinohe, Hiroki Mizukami, Sho Osonoi, Kazuhiro Kudo, Soroku Yagihashi

DIABETES   69   2020.6

Possible Implication of Cyclin D2 in Beta-Cell Proliferation of Human Perinatal Islet

Sho Osonoi, Hiroshi Ichinohe, Kazuhiro Kudo, Soroku Yagihashi, Hiroki Mizukami

DIABETES   69   2020.6

Biphasic changes in beta-cell mass around parturition are accompanied by increased serotonin production

Masaya Takahashi, Takeshi Miyatsuka, Luka Suzuki, Sho Osonoi, Miwa Himuro, Masaki Miura, Takehiro Katahira, Yuka Wakabayashi, Ayako Fukunaka, Yuya Nishida, Yoshio Fujitani, Satoru Takeda, Hiroki Mizukami, Atsuo Itakura, Hirotaka Watada

SCIENTIFIC REPORTS   10 ( 1 )   4962   2020.3

Biphasic changes in β-cell mass around parturition are accompanied by increased serotonin production.

Takahashi M, Miyatsuka T, Suzuki L, Osonoi S, Himuro M, Miura M, Katahira T, Wakabayashi Y, Fukunaka A, Nishida Y, Fujitani Y, Takeda S, Mizukami H, Itakura A, Watada H.

Sci Rep.   10 ( 1 )   4962   2020.3

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.

Moon JH, Kim YG, Kim K, Osonoi S, Wang S, Saunders DC, Wang J, Yang K, Kim H, Lee J, Jeong JS, Banerjee RR, Kim SK, Wu Y, Mizukami H, Powers AC, German MS, Kim H.

Diabetes.   69 ( 2 )   205 - 214   2020.2

Serotonin Regulates Adult beta-Cell Mass by Stimulating Perinatal beta-Cell Proliferation

Joon Ho Moon, Yeong Gi Kim, Kyuho Kim, Sho Osonoi, Shuang Wang, Diane C. Saunders, Juehu Wang, Katherine Yang, Hyeongseok Kim, Junguee Lee, Ji-Seon Jeong, Ronadip R. Banerjee, Seung K. Kim, Yingjie Wu, Hiroki Mizukami, Alvin C. Powers, Michael S. German, Hail Kim

DIABETES   69 ( 2 )   205 - 214   2020.2

Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation

Satoko Umetsu, Hiroki Mizukami, Takeshi Saito, Chiaki Uchida, Akiko Igawa, Kazuhiro Kudo, Chieko Itabashi, Sho Osonoi, Guo Danyang, Takanori Sasaki, Soroku Yagihashi, Kenichi Hakamada

SCIENTIFIC REPORTS   10 ( 1 )   1156   2020.1

Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation.

Umetsu S, Mizukami H, Saito T, Uchida C, Igawa A, Kudo K, Itabashi C, Osonoi S, Danyang G, Sasaki T, Yagihashi S, Hakamada K.

Sci Rep.   10 ( 1 )   1156   2020.1

Normal High HbA1c a Risk Factor for Abnormal Pain Threshold in the Japanese Population (vol 10, 651, 2019)

Chieko Itabashi, Hiroki Mizukami, Sho Osonoi, Kazuhisa Takahashi, Kazuhiro Kudo, Kanichiro Wada, Wataru Inaba, Guo Danyang, Chiaki Uchida, Satoko Umetsu, Akiko Igawa, Saori Ogasawara, Masaki Ryuzaki, Kouji Komeda, Yasuyuki Ishibashi, Soroku Yagihashi, Shigeyuki Nakaji

FRONTIERS IN ENDOCRINOLOGY   11   130   2020

Role of glucosamine in development of diabetic neuropathy independent of the aldose reductase pathway

Hiroki Mizukami, Sho Osonoi, Shizuka Takaku, Shin-Ichiro Yamagishi, Saori Ogasawara, Kazunori Sango, Sookja Chung, Soroku Yagihashi

BRAIN COMMUNICATIONS   2 ( 2 )   fcaa168   2020

Role of Dysregulated Ion Channels in Sensory Neurons in Chronic Kidney Disease-Associated Pruritus.

Momose A, Yabe M, Chiba S, Kumakawa K, Shiraiwa Y, Mizukami H

Medicines (Basel, Switzerland)   6 ( 4 )   2019.11

Normal High HbA1c a Risk Factor for Abnormal Pain Threshold in the Japanese Population.

Itabashi C, Mizukami H, Osonoi S, Takahashi K, Kudo K, Wada K, Inaba W,　Danyang G, Uchida C, Umetsu S, Igawa A, Ogasawara S, Ryuzaki M, Komeda K,　Ishibashi Y, Yagihashi S, Nakaji S.

Front Endocrinol (Lausanne).   10   651   2019.10

Dual Analysis with Nerve Ultrasound and Skin Biopsy in Painful Neuropathy Associated with Sjogren's Syndrome

Takeshi Yoshida, Hiroyuki Nodera, Yoshitaka Kumon, Hiroki Mizukami

ARTHRITIS & RHEUMATOLOGY   71   2019.10

Dysregulated Ion Channels in Sensory Neurons in Chronic Kidney Disease-Associated　Pruritus.

Momose A, Yabe M, Chiba S, Kumakawa K, Shiraiwa Y, Mizukami H.

Medicines (Basel)   2019.9

Deficit of Retrograde Axonal Transportation Was Mediated via Activation of Macrophage RAGE Signaling in Experimental Diabetic Polyneuropathy

Sho Osonoi, Hiroki Mizukami, Kazuhisa Takahashi, Kazuhiro Kudo, Kazunori Sango, Soroku Yagihashi

DIABETES   68   2019.6

Reduced Islet Parasympathetic Nerve Density Correlates with Decrease in Beta-Cell Volume of Islet in Lean Type 2 Diabetic Goto-Kakizaki Rat

Hiroki Mizukami, Danyang Guo, Kazuhisa Takahashi, Sho Osonoi, Kazuhiro Kudo, Soroku Yagihashi

DIABETES   68   2019.6

Mild Increase of Proinflammatory Macrophages Correlates with Reduction of Nerve Fiber Density in Sural Nerve of Human Type 2 Diabetic Subjects

Hiroki Mizukami, Sho Osonoi, Kazuhisa Takahashi, Kazuhiro Kudo, Chieko Itabashi, Soroku Yagihashi

DIABETES   68   2019.6

Islet Endocrine Cells Shows a Unique Pattern on Development and Growth of Each Cell Type in Human Subjects

Sho Osonoi, Hiroki Mizukami, Kazuhisa Takahashi, Kazuhiro Kudo, Soroku Yagihashi

DIABETES   68   2019.6

Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide.

Hara A, Nakagawa Y, Nakao K, Tamaki M, Ikemoto T, Shimada M, Matsuhisa M, Mizukami H, Maruyama N, Watada H, Fujitani Y.

Endocr J.   2019.5

MYH7 mutation identified by next-generation sequencing in three infant siblings with bi-ventricular noncompaction presenting with restrictive hemodynamics: A report of three siblings with a severe phenotype and poor prognosis.

Miura F, Shimada J, Kitagawa Y, Otani K, Sato T, Toki T, Takahashi T, Yonesaka S, Mizukami H, Ito E

Journal of cardiology cases   19 ( 4 )   140 - 143   2019.4

MYH7 mutation identified by next-generation sequencing in three infant siblings with bi-ventricular noncompaction presenting with restrictive hemodynamics: A report of three siblings with a severe phenotype and poor prognosis.

Miura F, Shimada J, Kitagawa Y, Otani K, Sato T, Toki T, Takahashi T, Yonesaka S, Mizukami H, Ito E.

J Cardiol Cases.   2019.2

Retinoic Acid‐inducible Gene‐I and CXCL10 are Involved in Biliary Atresia

Kimura Toshiro, Imaizumi Tadaatsu, Yoshida Tatsuya, Shimada Taku, Hayakari Ryo, Kawaguchi Shogo, Yoshida Hidemi, Kobayashi Tamotsu, Hirabayashi Takeshi, Mizukami Hiroki, Kijima Hiroshi, Hakamada Kenichi

Hirosaki Medical Journal   69 ( 1 )   86 - 94   2019

Normal High HbA1c a Risk Factor for Abnormal Pain Threshold in the Japanese Population

Chieko Itabashi, Hiroki Mizukami, Sho Osonoi, Kazuhisa Takahashi, Kazuhiro Kudo, Kanichiro Wada, Wataru Inaba, Guo Danyang, Chiaki Uchida, Satoko Umetsu, Akiko Igawa, Saori Ogasawara, Masaki Ryuzaki, Kouji Komeda, Yasuyuki Ishibashi, Soroku Yagihashi, Shigeyuki Nakaji

FRONTIERS IN ENDOCRINOLOGY   10   651   2019

Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide

Hara Akemi, Nakagawa Yuko, Nakao Keiko, Tamaki Motoyuki, Ikemoto Tetsuya, Shimada Mitsuo, Matsuhisa Munehide, Mizukami Hiroki, Maruyama Nobuhiro, Watada Hirotaka, Fujitani Yoshio

Endocrine Journal   66 ( 5 )   459 - 468   2019

alveolar rhabdomyosarcoma in skin of abdominal wall of elderly patient: a case report

Makoto Abe, Chieko Itabashi, Kazuhiro Kudo, Hiroki Mizukami

Human Pathology: Case Reports   13   49 - 52   2018.9

A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism

Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, Watabe K, Ogasawara

J Neurochem   144 ( 6 )   710 - 722   2018.6

A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism.

Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, Watabe K, Ogasawara S, Mizukami H, Yagihashi S, Chung SK, Sango K

Journal of neurochemistry   144 ( 6 )   710 - 722   2018.3

Pathological Findings of Diabetic Polyneuropathy -Evaluation by Corneal Confocal Microscopy and Skin Biopsy-

Mizukami Hiroki

Journal of the Japan Diabetes Society   61 ( 11 )   750 - 753   2018

Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation.

Saito T, Mizukami H, Umetsu S, Uchida C, Inaba W, Abe M, Takahashi K, Kudo K, Itabashi C, Yagihashi S, Hakamada K

Scientific reports   7 ( 1 )   18056   2017.12

High Osteogenic Potential of Adipose- and Muscle-derived Mesenchymal Stem Cells in Spinal-Ossification Model Mice.

Liu X, Kumagai G, Wada K, Tanaka T, Asari T, Oishi K, Fujita T, Mizukami H,他

Spine   2017.12

A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism.

Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, Watabe K, Ogasawara S, Mizukami H,他

Journal of Neurochemistry   2017.12

Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation.

Saito T, Mizukami H, 他

Scientific reports   7   18056   2017.12

Pancreas Atrophy and Islet Amyloid Deposition in Patients With Elderly-Onset Type 2 Diabetes.

Xin A, Mizukami H, Inaba W, Yoshida T, Takeuchi YK, Yagihashi S

The Journal of clinical endocrinology and metabolism   102 ( 9 )   3162 - 3171   2017.9

Pancreas Atrophy and Islet Amyloid Deposition in Patients With Elderly-Onset Type 2 Diabetes.

Xin A, Mizukami H, 他

Journal of Clinical Endocrinology and Metabolism   2017.9

Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa.

Funamizu Y, Nishijima H, Ueno T, Ueno S, Mizukami H, 他

Neuroscience Research   2017.8

Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa.

Funamizu Y, Nishijima H, Ueno T, Ueno S, Mizukami H, Yagihashi S, Tomiyama M

Neuroscience research   121   49 - 53   2017.8

CCL5 is induced by TLR 3 signaling in HuCCT1 human biliary epithelial cells: possible involvement in the pathogenesis of biliary atresia.

Shimada T, Imaizumi T, Shirai K, Tatsuta T, Kimura T, Hayakari R, Yoshida H, Matsumiya T, Kijima H, Mizukami H,他

Biomedical Research   2017.5

<b>CCL5 is induced by TLR 3 signaling in HuCCT1 human biliary epithelial cells: possible involvement in the pathogenesis of biliary atr</b><b>esia </b>

SHIMADA Taku, MIZUKAMI Hiroki, HAKAMADA Kenichi, IMAIZUMI Tadaatsu, SHIRAI Kyogo, TATSUTA Tetsuya, KIMURA Toshiro, HAYAKARI Ryo, YOSHIDA Hidemi, MATSUMIYA Tomoh, KIJIMA Hiroshi

Biomedical Research   38 ( 5 )   269 - 276   2017

A case of ACTH-producing primary thymic atypical carcinoid with tumor cells in the pericardial fluid

TONE Kiyoshi, KOJIMA Keiko, KUMAGAI Naoya, MIZUKAMI Hiroki, KUROSE Akira

The Journal of the Japanese Society of Clinical Cytology   56 ( 5 )   255 - 256   2017

Modified Parasympathetic Nervous System in Goto-Kakizaki Diabetic Rats

Han Chong, Inaba Wataru, Yonekura Manabu, Ogata Yoshiki, Ohba Takayoshi, Kushikata Tetsuya, Niwa Hidetoshi, Yanagisawa Teruyuki, Tomita Hirofumi, Itagaki Shirou, Hirota Kazuyoshi, Akai Hiroaki, Mizukami Hiroki, Murakami Manabu

弘前医学   68 ( 1 )   33 - 43   2017

Impaired Axonal Regeneration in Diabetes. Perspective on the Underlying Mechanism from <i>In Vivo</i> and <i>In Vitro</i> Experimental Studies.

Sango K, Mizukami H, Horie H, Yagihashi S

Frontiers in endocrinology   8   12   2017

Is Stem Cell Transplantation Ready for Prime Time in Diabetic Polyneuropathy?

Mizukami H, Yagihashi S

Current diabetes reports   16 ( 9 )   86   2016.9

Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation.

Taguchi Y, Allende ML, Mizukami H, Cook EK, Gavrilova O, Tuymetova G, Clarke BA, Chen W, Olivera A, Proia RL.

J Biol Chem.   291 ( 23 )   12029 - 12038   2016.6

Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation.

Taguchi Y, Allende ML, Mizukami H, Cook EK, Gavrilova O, Tuymetova G, Clarke BA, Chen W, Olivera A, Proia RL

The Journal of biological chemistry   291 ( 23 )   12029 - 38   2016.6

[Pathophysiology of diabetic polyneuropathy].

Mizukami H

Nihon rinsho. Japanese journal of clinical medicine   74 Suppl 2   229 - 33   2016.4

Dynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implications.

Yagihashi S, Inaba W, Mizukami H

Journal of diabetes investigation   7 ( 2 )   155 - 65   2016.3

The dipeptidyl peptidase IV inhibitor vildagliptin suppresses development of neuropathy in diabetic rodents: effects on peripheral sensory nerve function, structure and molecular changes.

Tsuboi K, Mizukami H, Inaba W, Baba M, Yagihashi S

Journal of neurochemistry   136 ( 4 )   859 - 870   2016.2

〈一般演題抄録〉下気道におけるレチノイン酸誘導遺伝子-Ⅰ様受容体を介した抗ウイルス自然免疫応答

千葉 友揮, 伊藤 悦朗, 松宮 朋穂, 佐藤 次生, 早狩 亮, 邢 飛, 吉田 秀見, 丹治 邦和, 水上 浩哉, 今泉 忠淳

弘前医学   67 ( 1 )   2016

The dipeptidyl peptidase IV inhibitor vildagliptin suppresses development of neuropathy in diabetic rodents: Effects on peripheral sensory nerve function, structure and molecular changes.

Tsuboi K, Mizukami H, Inaba W, Baba M, Yagihashi S.

J Neurochem.   2015.11

Retinoic acid-inducible gene-I-like receptor (RLR)-mediated antiviral innate immune responses in the lower respiratory tract: Roles of TRAF3 and TRAF5.

Chiba Y et al.

Biochem Biophys Res Commun.   467 ( 2 )   191 - 196   2015.11

Retinoic acid-inducible gene-I-like receptor (RLR)-mediated antiviral innate immune responses in the lower respiratory tract: Roles of TRAF3 and TRAF5.

Chiba Y, Matsumiya T, Satoh T, Hayakari R, Furudate K, Xing F, Yoshida H, Tanji K, Mizukami H, Imaizumi T, Ito E

Biochemical and biophysical research communications   467 ( 2 )   191 - 6   2015.11

Case of pachydermoperiostosis with solute carrier organic anion transporter family, member 2A1 (SLCO2A1) mutations.

Minakawa S, et al.

J Dermatol.   42 ( 9 )   908 - 910   2015.9

Quo vadis: Where have the β-cells gone?

Yagihashi S, Mizukami H, Inaba W

Journal of diabetes investigation   6 ( 4 )   393 - 5   2015.7

Case of oculocutaneous albinism complicated with squamous cell carcinoma, Bowen's disease and actinic keratosis.

Minakawa S, Kaneko T, Matsuzaki Y, Akasaka E, Mizukami H, Abe Y, Hozumi Y, Suzuki T, Mitsuhashi Y, Sawamura D

The Journal of dermatology   41 ( 9 )   863 - 4   2014.9

Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients.

Kamata K, Mizukami H, Inaba W, Tsuboi K, Tateishi Y, Yoshida T, Yagihashi S

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis   21 ( 3 )   191 - 201   2014.9

Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline of β-cell mass in Japanese type 2 diabetic patients.

Mizukami H, Takahashi K, Inaba W, Tsuboi K, Osonoi S, Yoshida T, Yagihashi S

Diabetes care   37 ( 7 )   1966 - 74   2014.7

B-cell malignant lymphoma presenting as otitis media and mastoiditis associated with sinus thrombosis.

Saito A, Jia W, Sasaki T, Mizukami H, Sasaki A, Shinkawa H, Nishijima M

Case reports in neurology   6 ( 2 )   161 - 5   2014.5

Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese.

Mizukami H, Takahashi K, Inaba W, Osonoi S, Kamata K, Tsuboi K, Yagihashi S

Journal of diabetes investigation   5 ( 1 )   38 - 47   2014.2

Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament.

Harada Y, Furukawa K, Asari T, Chin S, Ono A, Tanaka T, Mizukami H, Murakami M, Yagihashi S, Motomura S, Ishibashi Y

Biochemical and biophysical research communications   443 ( 3 )   1014 - 20   2014.1

Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients.

Kamata K他

Amyloid   21   191 - 201   2014

Involvement of Oxidative Stress-Induced DNA Damage, Endoplasmic Reticulum Stress, and Autophagy Deficits in the Decline of β-Cell Mass in Japanese Type 2 Diabetic Patients.

Mizukami H他

Diabetes Care   37   1966 - 1974   2014

Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament.

Harada Y他

Biochem Biophys Res Commun   443   1014 - 1020   2014

Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese, J Diabetes Invest.

Mizukami H他

J Diabetes Investig   5   38 - 47   2014

New Findings in the Pathogenesis of Diabetic Neuropathy

Mizukami H., Yagihashi S.

Journal of the Japan Diabetes Society   57 ( 8 )   609 - 612   2014

Exploring the mechanism of β cell deficit in type 2 diabetes

Hirosaki Medical Journal   65 ( 1 )   104 - 106   2014

Exploring a new therapy for diabetic polyneuropathy - the application of stem cell transplantation.

Mizukami H, Yagihashi S

Frontiers in endocrinology   5   45   2014

Exendin-4 improves beta cell function in autophagy-deficient beta cells.

Abe H他

Endocrinology   154 ( 12 )   4512 - 4524   2013.12

Exendin-4 improves β-cell function in autophagy-deficient β-cells.

Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku Y, Ogihara T, Uchiyama Y, Yagihashi S, Fujitani Y, Watada H

Endocrinology   154 ( 12 )   4512 - 24   2013.12

Impaired nerve fiber regeneration in axotomized peripheral nerves in streptozotocin-diabetic rats.

Nishida N, Yamagishi S, Mizukami H, Yagihashi S

Journal of diabetes investigation   4 ( 6 )   533 - 9   2013.11

Impaired nerve fiber regeneration in axotomized peripheral nerves in streptozotocin-diabetic rats.

Nishida N他

Journalof Diabetes Investigation   4 ( 6 )   533 - 539   2013.9

Immunohistochemical localization of mesenchymal stem cells in ossified human spinal ligaments.

Chin S他

Biochem Biophys Res Commun   436 ( 4 )   698 - 704   2013.7

Immunohistochemical localization of mesenchymal stem cells in ossified human spinal ligaments.

Chin S, Furukawa K, Ono A, Asari T, Harada Y, Wada K, Tanaka T, Inaba W, Mizukami H, Motomura S, Yagihashi S, Ishibashi Y

Biochemical and biophysical research communications   436 ( 4 )   698 - 704   2013.7

The effects of dipeptidyl-peptidase-IV inhibitor, vildagliptin, on the exocrine pancreas in spontaneously diabetic Goto-Kakizaki rats.

Mizukami H他

Pancreas.   42   786 - 794   2013.7

The effects of dipeptidyl-peptidase-IV inhibitor, vildagliptin, on the exocrine pancreas in spontaneously diabetic Goto-Kakizaki rats.

Mizukami H, Inaba W, Takahashi K, Kamata K, Tsuboi K, Yagihashi S

Pancreas   42 ( 5 )   786 - 94   2013.7

Alterations of α Cell Mass in Diabetes

MIZUKAMI H.

55 ( 11 )   845 - 848   2012.11

Loss of ARID1A expression is an early molecular event in tumor progression from ovarian endometriotic cyst to clear cell and endometrioid carcinoma.

Ayhan A, Mao TL, Seckin T, Wu CH, Guan B, Ogawa H, Futagami M, Mizukami H, Yokoyama Y, Kurman RJ, Shih IeM

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society   22 ( 8 )   1310 - 5   2012.10

Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on　islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats.

Inaba W

Eur J　Pharmacol.   691   297 - 36   2012.9

Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats.

Inaba W, Mizukami H, Kamata K, Takahashi K, Tsuboi K, Yagihashi S

European journal of pharmacology   691 ( 1-3 )   297 - 306   2012.9

The femoral insertion of the anterior cruciate ligament:　discrepancy between macroscopic and histological observations

Sasaki N

Arthroscopy   28 ( 8 )   1135 - 1146   2012.8

The femoral insertion of the anterior cruciate ligament: discrepancy between macroscopic and histological observations.

Sasaki N, Ishibashi Y, Tsuda E, Yamamoto Y, Maeda S, Mizukami H, Toh S, Yagihashi S, Tonosaki Y

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association   28 ( 8 )   1135 - 46   2012.8

Post injury changes in the properties of　mesenchymal stem cells derived from human anterior cruciate ligaments.

Nohmi S

Int　Orthop.   36 ( 7 )   1515 - 1522   2012.7

Augmented reduction of islet β-cell mass in Goto-Kakizaki rats fed high-fat diet and its suppression by pitavastatin treatment.

Mizukami H, Inaba W, Takahashi K, Inoue K, Sawanobori K, Yagihashi S

Journal of diabetes investigation   3 ( 3 )   235 - 44   2012.6

Mesenchymal stem cell isolation and　characterization from human spinal ligaments.

Asari T

Biochem Biophys Res Commun.   417 ( 4 )   1193 - 1199   2012.1

Mesenchymal stem cell isolation and characterization from human spinal ligaments.

Asari T, Furukawa K, Tanaka S, Kudo H, Mizukami H, Ono A, Numasawa T, Kumagai G, Motomura S, Yagihashi S, Toh S

Biochemical and biophysical research communications   417 ( 4 )   1193 - 9   2012.1

Efficacy of adipose tissue-derived mesenchymal stem cells for fulminant hepatitis　in mice induced by concanavalin A.

Kubo N

J Gastroenterol Hepatol.   27 ( 1 )   165 - 172   2012.1

Amelioration of acute kidney injury in lipopolysaccharide-induced systemic　inflammatory response syndrome by an aldose reductase inhibitor, fidarestat.

Takahashi K

PLoS　One.   7 ( 1 )   e30134   2012.1

Efficacy of adipose tissue-derived mesenchymal stem cells for fulminant hepatitis in mice induced by concanavalin A.

Kubo N, Narumi S, Kijima H, Mizukami H, Yagihashi S, Hakamada K, Nakane A

Journal of gastroenterology and hepatology   27 ( 1 )   165 - 72   2012.1

Amelioration of acute kidney injury in lipopolysaccharide-induced systemic inflammatory response syndrome by an aldose reductase inhibitor, fidarestat.

Takahashi K, Mizukami H, Kamata K, Inaba W, Kato N, Hibi C, Yagihashi S

PloS one   7 ( 1 )   e30134   2012

Alterations of <i>&alpha;</i> Cell Mass in Diabetes

Journal of the Japan Diabetes Society   55 ( 11 )   845 - 848   2012

Therapeutic effect of autologous adipose tissue-derived mesenchymal stem cell transplantation on the chronic experimental rat diabetic gastroenteropathy

MIZUKAMI Hiroki, TAKAHASHI Kazunori, SUGIMOTO Kazuhiro, BABA Masayuki, YAGIHASHI Soroku

22 ( 2 )   204 - 205   2011.12

Polyol pathway and diabetic nephropathy revisited: Early tubular cell changes and glomerulopathy in diabetic mice overexpressing human aldose reductase.

Hashimoto Y, Yamagishi S, Mizukami H, Yabe-Nishimura C, Lim SW, Kwon HM, Yagihashi S

Journal of diabetes investigation   2 ( 2 )   111 - 22   2011.4

Methylcobalamin effects on diabetic neuropathy and nerve protein kinase C in rats.

Mizukami H

Eur J Clin Invest.   41   442 - 450   2011.4

Mechanism of diabetic neuropathy: Where are we now and where to go?

Yagihashi S, Mizukami H, Sugimoto K

Journal of diabetes investigation   2 ( 1 )   18 - 32   2011.1

Therapeutic effect of autologous adipose tissue-derived mesenchymal stem cell transplantation on the established stage of experimental diabetic neuropathy

MIZUKAMI Hiroki, YAMAGISHI Shin-ichiro, OGASAWARA Saori, TAKAHASHI Kazunori, INABA Wataru, SUGIMOTO Kazuhiro, BABA Masayuki, YAGIHASHI Soroku

21 ( 2 )   338 - 339   2010.12

[Cytokine role in diabetic neuropathy].

Mizukami H, Yagihashi S

Nihon rinsho. Japanese journal of clinical medicine   68 Suppl 9   563 - 7   2010.11

A case of splenic follicular dendritic cell sarcoma, inflammatory pseudotumor-like variant

TAKAHASHI Kazunori, YAJIMA Nobuhisa, NAKAYAMA Yoshihito, MIZUKAMI Hiroki, WADA Ryuichi, ISHIGURO Ayako, GASA Fujihiko, YAGIHASHI Soroku

27 ( 3 )   229 - 232   2010.7

Serotonin regulates pancreatic beta cell mass during pregnancy.

Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, Fujitani Y, Kawamori R, Miyatsuka T, Kosaka Y, Yang K, Honig G, van der Hart M, Kishimoto N, Wang J, Yagihashi S, Tecott LH, Watada H, German MS

Nature medicine   16 ( 7 )   804 - 8   2010.7

The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice.

Yagihashi S, Mizukami H, Ogasawara S, Yamagishi S, Nukada H, Kato N, Hibi C, Chung S, Chung S

The Journal of pathology   220 ( 5 )   530 - 41   2010.4

Isolation of adipose tissue-derived mesenchymal stem cells and its effect of transplantation on the established stage of experimental diabetic neuropathy

MIZUKAMI Hiroki, YAMAGISHI Shin-ichiro, OGASAWARA Saori, INABA Wataru, YAGIHASHI Soroku

20 ( 2 )   207 - 208   2009.12

Small cell carcinoma with skeletal muscle differentiation of urinary bladder

YAJIMA Nobuhisa, MIZUKAMI Hiroki, WADA Ryuichi, SAITO Fumitada, YAGIHASHI Soroku

Pathology international   59 ( 10 )   748 - 751   2009.10

Small cell carcinoma with skeletal muscle differentiation of urinary bladder.

Yajima N, Mizukami H, Wada R, Saito F, Yagihashi S

Pathology international   59 ( 10 )   748 - 51   2009.10

Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma.

Shirasaki T, et. al.

BMC Cancer   8 ( 11 )   348 - 359   2008.11

Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma.

Shirasaki T, Maruya S, Mizukami H, Kakehata S, Kurotaki H, Yagihashi S, Shinkawa H

BMC cancer   8   348   2008.11

Suppression of post-prandial hyperglycaemia by pioglitazone improved islet fibrosis and macrophage migration in the Goto-Kakizaki rat.

Mizukami H, et al.

Diabetes, obesity & metabolism   10 ( 9 )   791 - 794   2008.9

自然発症糖尿病GKラットの糖代謝・膵島病変に対するピタバスタチンの作用

水上浩哉　他

PROGRESS IN MEDICINE   28 ( 4 )   999 - 1006   2008.4

Augmented beta cell loss and mitochondrial abnormalities in sucrose-fed GK rats.

Mizukami H, et al.

Virchows Archiv   452 ( 4 )   383 - 92   2008.4

Augmented beta cell loss and mitochondrial abnormalities in sucrose-fed GK rats.

Mizukami H, Wada R, Koyama M, Takeo T, Suga S, Wakui M, Yagihashi S

Virchows Archiv : an international journal of pathology   452 ( 4 )   383 - 92   2008.4

Correction of protein kinase C activity and macrophage migration in peripheral nerve by pioglitazone, peroxisome proliferator activated-gamma-ligand, in insulin-deficient diabetic rats.

Yamagishi S, Ogasawara S, Mizukami H, Yajima N, Wada R, Sugawara A, Yagihashi S

Journal of neurochemistry   104 ( 2 )   491 - 9   2008.1

Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells.

Takeda I, Maruya S, Shirasaki T, Mizukami H, Takahata T, Myers JN, Kakehata S, Yagihashi S, Shinkawa H

Cancer science   98 ( 6 )   890 - 9   2007.6

"jointly worked"

98 ( 6 )   890 - 899   2007.4

Implication of proinfl ammatory reactions in pathogenesis of diabetic microvascular complications

Yagihashi Soroku, Yamagishi Shin-ichiro, Mizukami Hiroki, Wada Ryuichi

弘前医学   59 ( 0 )   S101 - 108   2007

Novel mechanism of chronic exposure of oleic acid-induced insulin release impairment in rat pancreatic beta-cells.

Kudo T, et al.

The Journal of pharmacology and experimental therapeutics   318 ( 3 )   1203 - 1210   2006.9

Novel mechanism of chronic exposure of oleic acid-induced insulin release impairment in rat pancreatic beta-cells.

Kudo T, Wu J, Ogawa Y, Suga S, Hasegawa N, Suda T, Mizukami H, Yagihashi S, Wakui M

The Journal of pharmacology and experimental therapeutics   318 ( 3 )   1203 - 10   2006.9

Ganglioside GM3 promotes cell migration by regulating MAPK and c-Fos/AP-1.

Hashiramoto A, et al.

Oncogene   25 ( 28 )   3948 - 3955   2006.6

Pancreatic malignant fibrous histiocytoma, inflammatory myofibroblastic tumor, and inflammatory pseudotumor related to autoimmune pancreatitis

Mizukami H, et al.

Virchows Archiv : an international journal of pathology   448 ( 5 )   552 - 560   2006.5

Pancreatic malignant fibrous histiocytoma, inflammatory myofibroblastic tumor, and inflammatory pseudotumor related to autoimmune pancreatitis: characterization and differential diagnosis.

Mizukami H, Yajima N, Wada R, Matsumoto K, Kojima M, Klöppel G, Yagihashi S

Virchows Archiv : an international journal of pathology   448 ( 5 )   552 - 60   2006.5

Aortic Valve Perforation Due to Latent Infective Endocarditis

MUNAKATA Mamoru, ITAYA Hiroyuki, MIZUKAMI Hiroki, ONO Yuichi

日本胸部外科学会雑誌 = The Japanese journal of thoracic and cardiovascular surgery   54 ( 2 )   67 - 69   2006.2

Aortic valve perforation due to latent infective endocarditis.

Munakata M, et al.

The Japanese journal of thoracic and cardiovascular surgery   54 ( 2 )   67 - 69   2006.2

Spindle cell metaplasia arising in thyroid adenoma: characterization of its pathology and differential diagnosis.

Shikama Y, et al.

Journal of Endocrinological Investigation   29 ( 2 )   168 - 171   2006.2

Aortic valve perforation due to latent infective endocarditis.

Munakata M, Itaya H, Mizukami H, Ono Y

The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi   54 ( 2 )   67 - 9   2006.2

Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and　neuroendocrine cell markers in epithelial neoplasm of appendix.

Yajima N, et. al.

Human pathology   36 ( 11 )   1217 - 1225   2005.11

Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix.

Yajima N, Wada R, Yamagishi S, Mizukami H, Itabashi C, Yagihashi S

Human pathology   36 ( 11 )   1217 - 25   2005.11

Interruption of ganglioside synthesis produces central nervous system　degeneration and altered axon-glial interactions.

Yamashita T, et. al.

Proceedings of the National Academy of Sciences of the United States of America   102 ( 8 )   2725 - 2730   2005.2

Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions.

Yamashita T, Wu YP, Sandhoff R, Werth N, Mizukami H, Ellis JM, Dupree JL, Geyer R, Sandhoff K, Proia RL

Proceedings of the National Academy of Sciences of the United States of America   102 ( 8 )   2725 - 30   2005.2

Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the　brain of Niemann-Pick type C disease

Wu YP, et. al.

Molecular Genetics and Metabolism   84 ( 1 )   9 - 17   2005.1

Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease.

Wu YP, Mizukami H, Matsuda J, Saito Y, Proia RL, Suzuki K

Molecular genetics and metabolism   84 ( 1 )   9 - 17   2005.1

Global gene expression in a type 2 Gaucher disease brain

Myerowitz R, et. al.

MOLECULAR GENETICS AND METABOLISM   83 ( 4 )   288 - 296   2004.12

Global gene expression in a type 2 Gaucher disease brain.

Myerowitz R, Mizukami H, Richardson KL, Finn LS, Tifft CJ, Proia RL

Molecular genetics and metabolism   83 ( 4 )   288 - 96   2004.12

New Perspectives on the Pathogenesis and Treatment of Diabetic Neuropathy

YAGIHASHI Soroku, WADA Ryuichi, YAMAGISHI Shin-Ichiro, MIZUKAMI Hiroki

15 ( 1 )   1 - 16   2004.6

Enhanced insulin sensitivity in mice lacking ganglioside GM3

Yamashita T, et. al.

Proceedings of the National Academy of Sciences of the United States of America   100 ( 6 )   3445 - 3449   2003.3

Enhanced insulin sensitivity in mice lacking ganglioside GM3.

Yamashita T, Hashiramoto A, Haluzik M, Mizukami H, Beck S, Norton A, Kono M, Tsuji S, Daniotti JL, Werth N, Sandhoff R, Sandhoff K, Proia RL

Proceedings of the National Academy of Sciences of the United States of America   100 ( 6 )   3445 - 9   2003.3

Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles.

Miura K, Bowman ED, Simon R, Peng AC, Robles AI, Jones RT, Katagiri T, He P, Mizukami H, Charboneau L, Kikuchi T, Liotta LA, Nakamura Y, Harris CC

Cancer research   62 ( 11 )   3244 - 50   2002.6

Molecular pathophysiology in Tay-Sachs and Sandhoff diseases as revealed by gene expression profiling.

Myerowitz R, Lawson D, Mizukami H, Mi Y, Tifft CJ, Proia RL

Human molecular genetics   11 ( 11 )   1343 - 50   2002.5

Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage.

Mizukami H, Mi Y, Wada R, Kono M, Yamashita T, Liu Y, Werth N, Sandhoff R, Sandhoff K, Proia RL

The Journal of clinical investigation   109 ( 9 )   1215 - 21   2002.5

Pathogenesis and Molecular Treatment Strategies of Diabetic Neuropathy Collateral Glucose-Utilizing Pathways in Diabetic Polyneuropathy.

Mizukami H, Osonoi S.

Int J Mol Sci.   22 ( 1 )   94   2020.12

糖尿病性神経障害の成因：解糖系側副路代謝

水上浩哉

月間糖尿病   ( 124 )   19 - 25   2020.5

神経障害の最近の進歩と課題　神経障害　動物実験における進歩と課題

水上浩哉

糖尿病合併症   33 ( 2 )   241 - 244   2019.5

【糖尿病性神経障害:Current and novel concept】糖尿病性神経障害の成因

水上浩哉

糖尿病の最新治療   10 ( 3 )   133 - 139   2019.3

Impaired Axonal Regeneration in Diabetes. Perspective on the Underlying Mechanism from In Vivo and In Vitro Experimental Studies.

Sango K, Mizukami H,他

Frontier Endocrinology (Lausanne).   2017.2

Is Stem Cell Transplantation Ready for Prime Time in Diabetic Polyneuropathy?

Mizukami H, Yagihashi S.

Curr Diab Rep.   16 ( 9 )   86   2016.9

糖尿病性神経障害の成因　Up to Date

水上浩哉

糖尿病合併症   2016.6

糖尿病性神経障害の病理・病態

水上浩哉

日本臨床増刊　新時代の臨床糖尿病学   2016.4

Dynamic pathology of islet endocrine cellsin type 2 diabetes: β-Cell growth, death, regeneration and their clinical implications.

Yagihashi S, Inaba W, Mizukami H.

J Diabetes Investig.   7 ( 2 )   155 - 165   2016.3

生活習慣病と病理学

水上浩哉

臨床検査センター　50年の歩み   17 - 22   2015.12

糖尿病性神経障害の成因とその治療

水上浩哉

Diabetes Frontier   26 ( 4 )   460 - 465   2015.8

Quo vadis: Where have the β-cells gone?

Yagihashi S, Mizukami H, Inaba W.

Diabetes Investig.   6 ( 4 )   393 - 395   2015.7

糖尿病性ニューロパチー

水上浩哉他

月刊　臨床神経科学   32 ( 12 )   1404 - 1406   2014

ヒト膵β細胞容積はダイナミックに変化して2型糖尿病の病態に関与するか？

水上浩哉

内分泌・糖尿病・代謝内科   39 ( 2 )   132 - 138   2014

Exploring a New Therapy for Diabetic Polyneuropathy -The Application of Stem Cell Transplantation.

Mizukami H他

Front Endocrinol (Lausanne)   5   45   2014

糖尿病神経障害の病理

水上浩哉、八木橋操六

プラクティス   30 ( 4 )   429 - 426   2013.7

糖尿病性多発神経障害の成因を考える

水上浩哉、八木橋操六

月刊糖尿病   5   6 - 13   2013.6

基礎の面から-インクレチン関連薬のβ細胞保護作用

水上浩哉

糖尿病診療マスター   11 ( 1 )   44 - 49   2013.1

糖尿病発症・進展におけるグルカゴンの重要性 3　糖尿病におけるα細胞の相対的・絶対的な量の変化

水上浩哉

糖尿病   55 ( 11 )   605 - 608   2012.11

新しい糖尿病神経障害の治療②

水上浩哉

PRACTICE   29 ( 6 )   605 - 608   2012.11

新しい糖尿病神経障害の治療

水上浩哉

PRACTICE   29 ( 5 )   489 - 492   2012.9

糖尿病性神経障害における病理変化とその評価法

水上浩哉

糖尿病の最新治療   3 ( 4 )   194 - 199   2012.8

糖尿病性神経障害に対する細胞移植治療　―脂肪由来間葉系幹細胞を用いた検討―

水上浩哉

Peripheral Nerve   23 ( 1 )   87 - 94   2012.7

新しい糖尿病神経障害の評価

水上浩哉

PRACTICE   29 ( 4 )   357 - 360   2012.7

膵島の保護,改善 : β細胞死を防ぎ,再生を促す

水上浩哉

Islet equality   3 ( 1 )   3 - 8   2011.3

糖尿病性神経障害の病理

水上浩哉

月刊糖尿病   3 ( 3 )   20 - 25   2011.3

優秀賞

2022.12

若手研究奨励賞

2022.05

第26回弘前大学医学部学術賞　学術奨励賞

2022.01

優秀賞

2021.12

最優秀賞

2021.12

優秀演題賞

2021.10

Young Investigator Award

2021.09

第25回弘前大学医学部学術賞　学術奨励賞

2021.01

糖尿病性神経障害を考える会 八木橋操六賞

2020.12

第15回糖尿病トランスレーショナルリサーチ研究会　学生優秀賞

2020.12

第15回糖尿病トランスレーショナルリサーチ研究会　学生最優秀賞

2020.12

2020年度日本消化器関連学会　ポスター優秀演題賞

2020.11

2020年度日本消化器関連学会　若手奨励賞

2020.11

2020年度日本消化器関連学会　若手奨励賞

2020.11

糖尿病トランスレーショナルリサーチ研究会　学生優秀発表賞　

2019.12

糖尿病トランスレーショナルリサーチ研究会　学生最優秀研究賞

2019.12

弘前メディカルサイエンスフォーラム　最優秀賞

2019.11

糖尿病性神経障害を考える会　優秀演題賞

2019.08

第108回日本病理学会総会　学生優秀発表賞

2019.05

第108回日本病理学会総会　学生優秀発表賞

2019.05

糖尿病トランスレーショナルリサーチ研究会　学生優秀発表賞　

2018.12

学生発表賞

2018.06

学生発表賞

2018.06

学生発表賞

2018.06

第２２回弘前⼤学医学部学術賞

2018.01

young Investigator award

2017.07

弘前糖尿病トランスレーショナル研究会　最優秀発表賞

2016.12

平成28年度　糖尿病性神経障害を考える会　Student investigator award

2016.09

日本糖尿病・肥満動物学会「研究賞」

2016.03

優秀演題賞

2015.12

優秀演題賞

2015.12

平成27年度研究室研修優秀発表賞

2015.10

第19回弘前大学医学部学術奨励賞

2015.01

弘前大学医学部学学術特別賞

2014.01

第22回日本末梢神経学会学術集会　研究奨励賞

2011.09

第52回日本糖尿病学会年次集会　プレジデントポスター

2009.05