Papers - MIZUKAMI HIROKI
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RAGE activation in macrophages and development of experimental diabetic polyneuropathy.
Osonoi S, Mizukami H, Takeuchi Y, Sugawa H, Ogasawara S, Takaku S, Sasaki T, Kudoh K, Ito K, Sango K, Nagai R, Yamamoto Y, Daimon M, Yamamoto H, Yagihashi S.
JCI Insight 7 ( 23 ) e160555. 2022.12
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Dual epigenetic changes in diabetes mellitus-associated pancreatic ductal adenocarcinoma correlate with downregulation of E-cadherin and worsened prognosis.
1. Hara Y, Mizukami H, Yamazaki K, Yamada T, Igawa A, Takeuchi Y, Sasaki T, Kushibiki H, Murakami K, Kudoh K, Ishido K, Hakamada K.
J Pathol Clin Res. 9 ( 5 ) 354 - 366. 2023.9
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Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma.
Pan X, Mizukami H, Hara Y, Yamada T, Yamazaki K, Kudoh K, Takeuchi Y, Sasaki T, Kushibiki H, Igawa A, Hakamada K.
J Diabetes Investig. 14 ( 1 ) 132 - 144 2023.1
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Pathological substrate of memory impairment in multiple system atrophy.
Miki Y, Tanji K, Shinnai K, Tanaka MT, Altay F, Foti SC, Strand C, Sasaki T, Kon T, Shimoyama S, Furukawa T, Nishijima H, Yamazaki H, Asi YT, Bettencourt C, Jaunmuktane Z, Tada M, Mori F, Mizukami H, Tomiyama M, Lashuel HA, Lashley T, Kakita A, Ling H, Lees AJ, Holton JL, Warner TT, Wakabayashi K.
Neuropathol Appl Neurobiol. 48 ( 7 ) e12844 2022.12
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The diversity and abundance of gut microbiota are associated with the pain sensation threshold in the Japanese population.
Takeuchi Y, Mizukami H, Kudoh K, Osonoi S, Sasaki T, Kushibiki H, Ogasawara S, Hara Y, Igawa A, Pan X, Yamada T, Yamazaki K, Mikami T, Daimon M, Yagihashi S, Hakamada K, Nakaji S.
Neurobiol Dis. 173 105839. 2022.10
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Perivascular infiltration reflects subclinical lymph node metastasis in invasive lobular carcinoma.
Igawa A, Mizukami H, Kudoh K, Takeuchi Y, Sasaki T, Pan X, Hakamada K.
Virchows Arch. 481 ( 4 ) 533 - 543 2022.10
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Protocol to image and analyze the morphology of mouse peripheral nerves using transmission electron microscopy.
Nakai-Shimoda H, Himeno T, Motegi M, Ozeki N, Inoue R, Hayami T, Miura-Yura E, Yamada Y, Morishita Y, Tsunekawa S, Kato Y, Seino Y, Kondo M, Naruse K, Kato K, Mizukami H, Nakamura J, Kamiya H.
STAR Protoc 3 ( 3 ) 101591 2022.8
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Cumulative autophagy insufficiency in mice leads to progression of β-cell failure.
Suzuki L, Miyatsuka T, Himuro M, Wakabayashi Y, Osonoi S, Miura M, Katahira T, Fujitani Y, Iida H, Mizukami H, Nishida Y, Watada H.
Biochem Biophys Res Commun. 611 38 - 45 2022.6
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糖尿病性神経障害UPDATE:基礎と臨床の融合
水上浩哉，遲野井祥
糖尿病合併症 36 258 - 261 2022.6
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Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage.
Liu J, Kasai S, Tatara Y, Yamazaki H, Mimura J, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Tanji K, Wakabayashi K, Maeda H, Mizukami H, Shinkai Y, Kumagai Y, Tomita H, Itoh K.
Int J Mol Sci. 23 ( 6 ) 3201 2022.3
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Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves.
Nakai-Shimoda H, Himeno T, Okawa T, Miura-Yura E, Sasajima S, Kato M, Yamada Y, Morishita Y, Tsunekawa S, Kato Y, Seino Y, Inoue R, Kondo M, Seino S, Naruse K, Kato K, Mizukami H, Nakamura J, Kamiya H.
iScience. 25 ( 1 ) 103609 2021.12
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A case of dermatofibrosarcoma protuberans with neurofibromatous change.
2021 ( 11 ) rjab472 2021.12
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Islet microangiopathy and augmented β-cell loss in Japanese non-obese type 2 diabetes patients who died of acute myocardial infarction.
4. Takahashi K, Mizukami H, Osonoi S, Takeuchi Y, Kudoh K, Sasaki T, Daimon M, Yagihashi S.
J Diabetes Investig. 12 ( 12 ) 2149 - 2161 2021.12
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Diabetes in Humans Activates Pancreatic Stellate Cells via RAGE in Pancreatic Ductal Adenocarcinoma.
Uchida C, Mizukami H, Hara Y, Saito T, Umetsu S, Igawa A, Osonoi S, Kudoh K, Yamamoto Y, Yamamoto H, Yagihashi S, Hakamada K.
Int J Mol Sci. 22 ( 21 ) 11716 2021.10
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Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice
Takahashi K, Mizukami H, Osonoi S, Ogasawara S, Hara Y, Kudoh K, Takeuchi Y, Sasaki T, Daimon M, Yagihashi S
Neurobiol Dis. 155 105392 2021.7
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MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis.
Diabetes 70 ( 7 ) 1519 - 1535 2021.7
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Detection of nerve enlargement with ultrasound and correlation with skin biopsy findings in painful sensory neuropathy associated with Sjögren's syndrome.
Yoshida T, Nodera H, Kumon Y, Osanai S, Izumi Y, Mizukami H
Modern rheumatology 31 ( 4 ) 849 - 855 2021.7
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Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice.
Takahashi K, Mizukami H, Osonoi S, Ogasawara S, Hara Y, Kudoh K, Takeuchi Y, Sasaki T, Daimon M, Yagihashi S
Neurobiology of disease 155 105392 2021.7
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MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis.
Ikushima YM, Awazawa M, Kobayashi N, Osonoi S, Takemiya S, Kobayashi H, Suwanai H, Morimoto Y, Soeda K, Adachi J, Muratani M, Charron J, Mizukami H, Takahashi N, Ueki K
Diabetes 70 ( 7 ) 1519 - 1535 2021.7
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Islet microangiopathy and augmented β-cell loss in Japanese non-obese type 2 diabetes patients who died of acute myocardial infarction.
Takahashi K, Mizukami H, Osonoi S, Takeuchi Y, Kudoh K, Sasaki T, Daimon M, Yagihashi S
Journal of diabetes investigation 2021.5
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Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice.
1. Nakamura T, Nampei M, Murase T, Satoh E, Akari S, Katoh N, Mizukami H.
Nutr Diabetes 11 ( 1 ) 12 2021.4
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Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice.
Nakamura T, Nampei M, Murase T, Satoh E, Akari S, Katoh N, Mizukami H
Nutrition & diabetes 11 ( 1 ) 12 2021.4
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Pathogenesis and Molecular Treatment Strategies of Diabetic Neuropathy Collateral Glucose-Utilizing Pathways in Diabetic Polyneuropathy.
Mizukami H, Osonoi S
International journal of molecular sciences 22 ( 1 ) 2020.12
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Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population.
Osonoi S, Mizukami H, Itabashi C, Wada K, Kudoh K, Igawa A, Ogasawara S, Ishibashi Y, Daimon M, Yagihashi S, Nakaji S.
Int J Mol Sci. 21 ( 21 ) 8306 2020.11
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Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population.
Osonoi S, Mizukami H, Itabashi C, Wada K, Kudoh K, Igawa A, Ogasawara S, Ishibashi Y, Daimon M, Yagihashi S, Nakaji S
International journal of molecular sciences 21 ( 21 ) 2020.11
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Detection of nerve enlargement with ultrasound and correlation with skin biopsy findings in painful sensory neuropathy associated with Sjögren's syndrome.
Yoshida T, Nodera H, Kumon Y, Osanai S, Izumi Y, Mizukami H.
Mod Rheumatol. 1 - 7 2020.10
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Role of glucosamine in development of diabetic neuropathy independent of the aldose reductase pathway.
Mizukami H, Osonoi S, Takaku S, Yamagishi SI, Ogasawara S, Sango K, Chung S, Yagihashi S.
Brain Commun. 2 ( 2 ) fcaa168 2020.10
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Lipopolysaccharide-binding protein is a distinctive biomarker of abnormal pain threshold in the general Japanese population.
Kudoh K, Mizukami H, Itabashi C, Fuke N, Osonoi S, Takeuchi Y, Wada K, Igawa A, Ogasawara S, Ishibashi Y, Hakamada K, Yagihashi S, Nakaji S
BMJ open diabetes research & care 8 ( 1 ) 2020.10
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糖尿病性神経障害の病期と病態
遅野井 祥、水上浩哉
糖尿病合併症 34 ( 2 ) 262 - 264 2020.7
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Beneficial effects of combination therapy of canagliflozin and teneligliptin on diabetic polyneuropathy and β-cell volume density in spontaneously type 2 diabetic Goto-Kakizaki rats.
Guo D, Mizukami H, Osonoi S, Takahashi K, Ogasawara S, Kudo K, Sasaki T, Yagihashi S
Metabolism: clinical and experimental 107 154232 2020.6
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Biphasic changes in β-cell mass around parturition are accompanied by increased serotonin production.
Takahashi M, Miyatsuka T, Suzuki L, Osonoi S, Himuro M, Miura M, Katahira T, Wakabayashi Y, Fukunaka A, Nishida Y, Fujitani Y, Takeda S, Mizukami H, Itakura A, Watada H
Scientific reports 10 ( 1 ) 4962 2020.3
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Biphasic changes in β-cell mass around parturition are accompanied by increased serotonin production.
Takahashi M, Miyatsuka T, Suzuki L, Osonoi S, Himuro M, Miura M, Katahira T, Wakabayashi Y, Fukunaka A, Nishida Y, Fujitani Y, Takeda S, Mizukami H, Itakura A, Watada H.
Sci Rep. 10 ( 1 ) 4962 2020.3
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Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.
Moon JH, Kim YG, Kim K, Osonoi S, Wang S, Saunders DC, Wang J, Yang K, Kim H, Lee J, Jeong JS, Banerjee RR, Kim SK, Wu Y, Mizukami H, Powers AC, German MS, Kim H.
Diabetes. 69 ( 2 ) 205 - 214 2020.2
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Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.
Moon JH, Kim YG, Kim K, Osonoi S, Wang S, Saunders DC, Wang J, Yang K, Kim H, Lee J, Jeong JS, Banerjee RR, Kim SK, Wu Y, Mizukami H, Powers AC, German MS, Kim H
Diabetes 69 ( 2 ) 205 - 214 2020.2
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Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation.
Umetsu S, Mizukami H, Saito T, Uchida C, Igawa A, Kudo K, Itabashi C, Osonoi S, Danyang G, Sasaki T, Yagihashi S, Hakamada K
Scientific reports 10 ( 1 ) 1156 2020.1
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Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation.
Umetsu S, Mizukami H, Saito T, Uchida C, Igawa A, Kudo K, Itabashi C, Osonoi S, Danyang G, Sasaki T, Yagihashi S, Hakamada K.
Sci Rep. 10 ( 1 ) 1156 2020.1
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Corrigendum: Normal High HbA1c a Risk Factor for Abnormal Pain Threshold in the Japanese Population.
Itabashi C, Mizukami H, Osonoi S, Takahashi K, Kudo K, Wada K, Inaba W, Danyang G, Uchida C, Umetsu S, Igawa A, Ogasawara S, Ryuzaki M, Komeda K, Ishibashi Y, Yagihashi S, Nakaji S
Frontiers in endocrinology 11 130 2020
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Role of glucosamine in development of diabetic neuropathy independent of the aldose reductase pathway.
Mizukami H, Osonoi S, Takaku S, Yamagishi SI, Ogasawara S, Sango K, Chung S, Yagihashi S
Brain communications 2 ( 2 ) fcaa168 2020
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Role of Dysregulated Ion Channels in Sensory Neurons in Chronic Kidney Disease-Associated Pruritus.
Momose A, Yabe M, Chiba S, Kumakawa K, Shiraiwa Y, Mizukami H
Medicines (Basel, Switzerland) 6 ( 4 ) 2019.11
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Normal High HbA1c a Risk Factor for Abnormal Pain Threshold in the Japanese Population.
Itabashi C, Mizukami H, Osonoi S, Takahashi K, Kudo K, Wada K, Inaba W, Danyang G, Uchida C, Umetsu S, Igawa A, Ogasawara S, Ryuzaki M, Komeda K, Ishibashi Y, Yagihashi S, Nakaji S.
Front Endocrinol (Lausanne). 10 651 2019.10
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Dysregulated Ion Channels in Sensory Neurons in Chronic Kidney Disease-Associated Pruritus.
Momose A, Yabe M, Chiba S, Kumakawa K, Shiraiwa Y, Mizukami H.
Medicines (Basel) 2019.9
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Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide.
Hara A, Nakagawa Y, Nakao K, Tamaki M, Ikemoto T, Shimada M, Matsuhisa M, Mizukami H, Maruyama N, Watada H, Fujitani Y.
Endocr J. 2019.5
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MYH7 mutation identified by next-generation sequencing in three infant siblings with bi-ventricular noncompaction presenting with restrictive hemodynamics: A report of three siblings with a severe phenotype and poor prognosis.
Miura F, Shimada J, Kitagawa Y, Otani K, Sato T, Toki T, Takahashi T, Yonesaka S, Mizukami H, Ito E
Journal of cardiology cases 19 ( 4 ) 140 - 143 2019.4
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MYH7 mutation identified by next-generation sequencing in three infant siblings with bi-ventricular noncompaction presenting with restrictive hemodynamics: A report of three siblings with a severe phenotype and poor prognosis.
Miura F, Shimada J, Kitagawa Y, Otani K, Sato T, Toki T, Takahashi T, Yonesaka S, Mizukami H, Ito E.
J Cardiol Cases. 2019.2
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Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide
Hara Akemi, Watada Hirotaka, Fujitani Yoshio, Nakagawa Yuko, Nakao Keiko, Tamaki Motoyuki, Ikemoto Tetsuya, Shimada Mitsuo, Matsuhisa Munehide, Mizukami Hiroki, Maruyama Nobuhiro
Endocrine Journal 66 ( 5 ) 459 - 468 2019
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Normal High HbA1c a Risk Factor for Abnormal Pain Threshold in the Japanese Population.
Itabashi C, Mizukami H, Osonoi S, Takahashi K, Kudo K, Wada K, Inaba W, Danyang G, Uchida C, Umetsu S, Igawa A, Ogasawara S, Ryuzaki M, Komeda K, Ishibashi Y, Yagihashi S, Nakaji S
Frontiers in endocrinology 10 651 2019
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Retinoic Acid-Inducible Gene-i and CXCL10 are Involved in Biliary Atresia
Kimura Toshiro, Imaizumi Tadaatsu, Yoshida Tatsuya, Shimada Taku, Hayakari Ryo, Kawaguchi Shogo, Yoshida Hidemi, Kobayashi Tamotsu, Hirabayashi Takeshi, Mizukami Hiroki, Kijima Hiroshi, Hakamada Kenichi
弘前医学 69 ( 1 ) 86 - 94 2019
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alveolar rhabdomyosarcoma in skin of abdominal wall of elderly patient: a case report
Makoto Abe, Chieko Itabashi, Kazuhiro Kudo, Hiroki Mizukami
Human Pathology: Case Reports 13 49 - 52 2018.9
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A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism
Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, Watabe K, Ogasawara
J Neurochem 144 ( 6 ) 710 - 722 2018.6
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A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism.
Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, Watabe K, Ogasawara S, Mizukami H, Yagihashi S, Chung SK, Sango K
Journal of neurochemistry 144 ( 6 ) 710 - 722 2018.3
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Pathological Findings of Diabetic Polyneuropathy -Evaluation by Corneal Confocal Microscopy and Skin Biopsy-
Mizukami Hiroki
Journal of the Japan Diabetes Society 61 ( 11 ) 750 - 753 2018
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Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation.
Saito T, Mizukami H, Umetsu S, Uchida C, Inaba W, Abe M, Takahashi K, Kudo K, Itabashi C, Yagihashi S, Hakamada K
Scientific reports 7 ( 1 ) 18056 2017.12
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High Osteogenic Potential of Adipose- and Muscle-derived Mesenchymal Stem Cells in Spinal-Ossification Model Mice.
Liu X, Kumagai G, Wada K, Tanaka T, Asari T, Oishi K, Fujita T, Mizukami H,他
Spine 2017.12
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A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism.
Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, Watabe K, Ogasawara S, Mizukami H,他
Journal of Neurochemistry 2017.12
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Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation.
Saito T, Mizukami H, 他
Scientific reports 7 18056 2017.12
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Pancreas Atrophy and Islet Amyloid Deposition in Patients With Elderly-Onset Type 2 Diabetes.
Xin A, Mizukami H, Inaba W, Yoshida T, Takeuchi YK, Yagihashi S
The Journal of clinical endocrinology and metabolism 102 ( 9 ) 3162 - 3171 2017.9
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Pancreas Atrophy and Islet Amyloid Deposition in Patients With Elderly-Onset Type 2 Diabetes.
Xin A, Mizukami H, 他
Journal of Clinical Endocrinology and Metabolism 2017.9
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Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa.
Funamizu Y, Nishijima H, Ueno T, Ueno S, Mizukami H, 他
Neuroscience Research 2017.8
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Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa.
Funamizu Y, Nishijima H, Ueno T, Ueno S, Mizukami H, Yagihashi S, Tomiyama M
Neuroscience research 121 49 - 53 2017.8
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CCL5 is induced by TLR 3 signaling in HuCCT1 human biliary epithelial cells: possible involvement in the pathogenesis of biliary atresia.
Shimada T, Imaizumi T, Shirai K, Tatsuta T, Kimura T, Hayakari R, Yoshida H, Matsumiya T, Kijima H, Mizukami H,他
Biomedical Research 2017.5
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<b>CCL5 is induced by TLR 3 signaling in HuCCT1 human biliary epithelial cells: possible involvement in the pathogenesis of biliary atr</b><b>esia </b>
SHIMADA Taku, MIZUKAMI Hiroki, HAKAMADA Kenichi, IMAIZUMI Tadaatsu, SHIRAI Kyogo, TATSUTA Tetsuya, KIMURA Toshiro, HAYAKARI Ryo, YOSHIDA Hidemi, MATSUMIYA Tomoh, KIJIMA Hiroshi
Biomedical Research 38 ( 5 ) 269 - 276 2017
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Impaired Axonal Regeneration in Diabetes. Perspective on the Underlying Mechanism from <i>In Vivo</i> and <i>In Vitro</i> Experimental Studies.
Sango K, Mizukami H, Horie H, Yagihashi S
Frontiers in endocrinology 8 12 2017
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A case of ACTH-producing primary thymic atypical carcinoid with tumor cells in the pericardial fluid
TONE Kiyoshi, KOJIMA Keiko, KUMAGAI Naoya, MIZUKAMI Hiroki, KUROSE Akira
The Journal of the Japanese Society of Clinical Cytology 56 ( 5 ) 255 - 256 2017
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Modified Parasympathetic Nervous System in Goto-Kakizaki Diabetic Rats
Han Chong, Inaba Wataru, Yonekura Manabu, Ogata Yoshiki, Ohba Takayoshi, Kushikata Tetsuya, Niwa Hidetoshi, Yanagisawa Teruyuki, Tomita Hirofumi, Itagaki Shirou, Hirota Kazuyoshi, Akai Hiroaki, Mizukami Hiroki, Murakami Manabu
弘前医学 68 ( 1 ) 33 - 43 2017
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Is Stem Cell Transplantation Ready for Prime Time in Diabetic Polyneuropathy?
Mizukami H, Yagihashi S
Current diabetes reports 16 ( 9 ) 86 2016.9
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Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation.
Taguchi Y, Allende ML, Mizukami H, Cook EK, Gavrilova O, Tuymetova G, Clarke BA, Chen W, Olivera A, Proia RL.
J Biol Chem. 291 ( 23 ) 12029 - 12038 2016.6
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Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation.
Taguchi Y, Allende ML, Mizukami H, Cook EK, Gavrilova O, Tuymetova G, Clarke BA, Chen W, Olivera A, Proia RL
The Journal of biological chemistry 291 ( 23 ) 12029 - 38 2016.6
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[Pathophysiology of diabetic polyneuropathy].
Mizukami H
Nihon rinsho. Japanese journal of clinical medicine 74 Suppl 2 229 - 33 2016.4
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Dynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implications.
Yagihashi S, Inaba W, Mizukami H
Journal of diabetes investigation 7 ( 2 ) 155 - 65 2016.3
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The dipeptidyl peptidase IV inhibitor vildagliptin suppresses development of neuropathy in diabetic rodents: effects on peripheral sensory nerve function, structure and molecular changes.
Tsuboi K, Mizukami H, Inaba W, Baba M, Yagihashi S
Journal of neurochemistry 136 ( 4 ) 859 - 870 2016.2
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〈一般演題抄録〉下気道におけるレチノイン酸誘導遺伝子-Ⅰ様受容体を介した抗ウイルス自然免疫応答
千葉 友揮, 伊藤 悦朗, 松宮 朋穂, 佐藤 次生, 早狩 亮, 邢 飛, 吉田 秀見, 丹治 邦和, 水上 浩哉, 今泉 忠淳
弘前医学 67 ( 1 ) 2016
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The dipeptidyl peptidase IV inhibitor vildagliptin suppresses development of neuropathy in diabetic rodents: Effects on peripheral sensory nerve function, structure and molecular changes.
Tsuboi K, Mizukami H, Inaba W, Baba M, Yagihashi S.
J Neurochem. 2015.11
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Retinoic acid-inducible gene-I-like receptor (RLR)-mediated antiviral innate immune responses in the lower respiratory tract: Roles of TRAF3 and TRAF5.
Chiba Y et al.
Biochem Biophys Res Commun. 467 ( 2 ) 191 - 196 2015.11
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Retinoic acid-inducible gene-I-like receptor (RLR)-mediated antiviral innate immune responses in the lower respiratory tract: Roles of TRAF3 and TRAF5.
Chiba Y, Matsumiya T, Satoh T, Hayakari R, Furudate K, Xing F, Yoshida H, Tanji K, Mizukami H, Imaizumi T, Ito E
Biochemical and biophysical research communications 467 ( 2 ) 191 - 6 2015.11
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Case of pachydermoperiostosis with solute carrier organic anion transporter family, member 2A1 (SLCO2A1) mutations.
Minakawa S, et al.
J Dermatol. 42 ( 9 ) 908 - 910 2015.9
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Quo vadis: Where have the β-cells gone?
Yagihashi S, Mizukami H, Inaba W
Journal of diabetes investigation 6 ( 4 ) 393 - 5 2015.7
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Case of oculocutaneous albinism complicated with squamous cell carcinoma, Bowen's disease and actinic keratosis.
Minakawa S, Kaneko T, Matsuzaki Y, Akasaka E, Mizukami H, Abe Y, Hozumi Y, Suzuki T, Mitsuhashi Y, Sawamura D
The Journal of dermatology 41 ( 9 ) 863 - 4 2014.9
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Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients.
Kamata K, Mizukami H, Inaba W, Tsuboi K, Tateishi Y, Yoshida T, Yagihashi S
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 21 ( 3 ) 191 - 201 2014.9
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Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline of β-cell mass in Japanese type 2 diabetic patients.
Mizukami H, Takahashi K, Inaba W, Tsuboi K, Osonoi S, Yoshida T, Yagihashi S
Diabetes care 37 ( 7 ) 1966 - 74 2014.7
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B-cell malignant lymphoma presenting as otitis media and mastoiditis associated with sinus thrombosis.
Saito A, Jia W, Sasaki T, Mizukami H, Sasaki A, Shinkawa H, Nishijima M
Case reports in neurology 6 ( 2 ) 161 - 5 2014.5
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Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese.
Mizukami H, Takahashi K, Inaba W, Osonoi S, Kamata K, Tsuboi K, Yagihashi S
Journal of diabetes investigation 5 ( 1 ) 38 - 47 2014.2
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Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament.
Harada Y, Furukawa K, Asari T, Chin S, Ono A, Tanaka T, Mizukami H, Murakami M, Yagihashi S, Motomura S, Ishibashi Y
Biochemical and biophysical research communications 443 ( 3 ) 1014 - 20 2014.1
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Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients.
Kamata K他
Amyloid 21 191 - 201 2014
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Involvement of Oxidative Stress-Induced DNA Damage, Endoplasmic Reticulum Stress, and Autophagy Deficits in the Decline of β-Cell Mass in Japanese Type 2 Diabetic Patients.
Mizukami H他
Diabetes Care 37 1966 - 1974 2014
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Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament.
Harada Y他
Biochem Biophys Res Commun 443 1014 - 1020 2014
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Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese, J Diabetes Invest.
Mizukami H他
J Diabetes Investig 5 38 - 47 2014
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New Findings in the Pathogenesis of Diabetic Neuropathy
Mizukami H., Yagihashi S.
Journal of the Japan Diabetes Society 57 ( 8 ) 609 - 612 2014
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Exploring the mechanism of β cell deficit in type 2 diabetes
Hirosaki Medical Journal 65 ( 1 ) 104 - 106 2014
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Exploring a new therapy for diabetic polyneuropathy - the application of stem cell transplantation.
Mizukami H, Yagihashi S
Frontiers in endocrinology 5 45 2014
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Exendin-4 improves beta cell function in autophagy-deficient beta cells.
Abe H他
Endocrinology 154 ( 12 ) 4512 - 4524 2013.12
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Exendin-4 improves β-cell function in autophagy-deficient β-cells.
Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku Y, Ogihara T, Uchiyama Y, Yagihashi S, Fujitani Y, Watada H
Endocrinology 154 ( 12 ) 4512 - 24 2013.12
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Impaired nerve fiber regeneration in axotomized peripheral nerves in streptozotocin-diabetic rats.
Nishida N, Yamagishi S, Mizukami H, Yagihashi S
Journal of diabetes investigation 4 ( 6 ) 533 - 9 2013.11
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Impaired nerve fiber regeneration in axotomized peripheral nerves in streptozotocin-diabetic rats.
Nishida N他
Journalof Diabetes Investigation 4 ( 6 ) 533 - 539 2013.9
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Immunohistochemical localization of mesenchymal stem cells in ossified human spinal ligaments.
Chin S他
Biochem Biophys Res Commun 436 ( 4 ) 698 - 704 2013.7
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Immunohistochemical localization of mesenchymal stem cells in ossified human spinal ligaments.
Chin S, Furukawa K, Ono A, Asari T, Harada Y, Wada K, Tanaka T, Inaba W, Mizukami H, Motomura S, Yagihashi S, Ishibashi Y
Biochemical and biophysical research communications 436 ( 4 ) 698 - 704 2013.7
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The effects of dipeptidyl-peptidase-IV inhibitor, vildagliptin, on the exocrine pancreas in spontaneously diabetic Goto-Kakizaki rats.
Mizukami H他
Pancreas. 42 786 - 794 2013.7
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The effects of dipeptidyl-peptidase-IV inhibitor, vildagliptin, on the exocrine pancreas in spontaneously diabetic Goto-Kakizaki rats.
Mizukami H, Inaba W, Takahashi K, Kamata K, Tsuboi K, Yagihashi S
Pancreas 42 ( 5 ) 786 - 94 2013.7
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Alterations of α Cell Mass in Diabetes
MIZUKAMI H.
55 ( 11 ) 845 - 848 2012.11
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Loss of ARID1A expression is an early molecular event in tumor progression from ovarian endometriotic cyst to clear cell and endometrioid carcinoma.
Ayhan A, Mao TL, Seckin T, Wu CH, Guan B, Ogawa H, Futagami M, Mizukami H, Yokoyama Y, Kurman RJ, Shih IeM
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 22 ( 8 ) 1310 - 5 2012.10
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Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats.
Inaba W
Eur J Pharmacol. 691 297 - 36 2012.9
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Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats.
Inaba W, Mizukami H, Kamata K, Takahashi K, Tsuboi K, Yagihashi S
European journal of pharmacology 691 ( 1-3 ) 297 - 306 2012.9
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The femoral insertion of the anterior cruciate ligament: discrepancy between macroscopic and histological observations
Sasaki N
Arthroscopy 28 ( 8 ) 1135 - 1146 2012.8
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The femoral insertion of the anterior cruciate ligament: discrepancy between macroscopic and histological observations.
Sasaki N, Ishibashi Y, Tsuda E, Yamamoto Y, Maeda S, Mizukami H, Toh S, Yagihashi S, Tonosaki Y
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 28 ( 8 ) 1135 - 46 2012.8
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Post injury changes in the properties of mesenchymal stem cells derived from human anterior cruciate ligaments.
Nohmi S
Int Orthop. 36 ( 7 ) 1515 - 1522 2012.7
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Augmented reduction of islet β-cell mass in Goto-Kakizaki rats fed high-fat diet and its suppression by pitavastatin treatment.
Mizukami H, Inaba W, Takahashi K, Inoue K, Sawanobori K, Yagihashi S
Journal of diabetes investigation 3 ( 3 ) 235 - 44 2012.6
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Mesenchymal stem cell isolation and characterization from human spinal ligaments.
Asari T
Biochem Biophys Res Commun. 417 ( 4 ) 1193 - 1199 2012.1
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Mesenchymal stem cell isolation and characterization from human spinal ligaments.
Asari T, Furukawa K, Tanaka S, Kudo H, Mizukami H, Ono A, Numasawa T, Kumagai G, Motomura S, Yagihashi S, Toh S
Biochemical and biophysical research communications 417 ( 4 ) 1193 - 9 2012.1
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Efficacy of adipose tissue-derived mesenchymal stem cells for fulminant hepatitis in mice induced by concanavalin A.
Kubo N
J Gastroenterol Hepatol. 27 ( 1 ) 165 - 172 2012.1
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Amelioration of acute kidney injury in lipopolysaccharide-induced systemic inflammatory response syndrome by an aldose reductase inhibitor, fidarestat.
Takahashi K
PLoS One. 7 ( 1 ) e30134 2012.1
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Efficacy of adipose tissue-derived mesenchymal stem cells for fulminant hepatitis in mice induced by concanavalin A.
Kubo N, Narumi S, Kijima H, Mizukami H, Yagihashi S, Hakamada K, Nakane A
Journal of gastroenterology and hepatology 27 ( 1 ) 165 - 72 2012.1
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Amelioration of acute kidney injury in lipopolysaccharide-induced systemic inflammatory response syndrome by an aldose reductase inhibitor, fidarestat.
Takahashi K, Mizukami H, Kamata K, Inaba W, Kato N, Hibi C, Yagihashi S
PloS one 7 ( 1 ) e30134 2012
-
Alterations of <i>α</i> Cell Mass in Diabetes
Journal of the Japan Diabetes Society 55 ( 11 ) 845 - 848 2012
-
Therapeutic effect of autologous adipose tissue-derived mesenchymal stem cell transplantation on the chronic experimental rat diabetic gastroenteropathy
MIZUKAMI Hiroki, TAKAHASHI Kazunori, SUGIMOTO Kazuhiro, BABA Masayuki, YAGIHASHI Soroku
22 ( 2 ) 204 - 205 2011.12
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Polyol pathway and diabetic nephropathy revisited: Early tubular cell changes and glomerulopathy in diabetic mice overexpressing human aldose reductase.
Hashimoto Y, Yamagishi S, Mizukami H, Yabe-Nishimura C, Lim SW, Kwon HM, Yagihashi S
Journal of diabetes investigation 2 ( 2 ) 111 - 22 2011.4
-
Methylcobalamin effects on diabetic neuropathy and nerve protein kinase C in rats.
Mizukami H
Eur J Clin Invest. 41 442 - 450 2011.4
-
Mechanism of diabetic neuropathy: Where are we now and where to go?
Yagihashi S, Mizukami H, Sugimoto K
Journal of diabetes investigation 2 ( 1 ) 18 - 32 2011.1
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Therapeutic effect of autologous adipose tissue-derived mesenchymal stem cell transplantation on the established stage of experimental diabetic neuropathy
MIZUKAMI Hiroki, YAMAGISHI Shin-ichiro, OGASAWARA Saori, TAKAHASHI Kazunori, INABA Wataru, SUGIMOTO Kazuhiro, BABA Masayuki, YAGIHASHI Soroku
21 ( 2 ) 338 - 339 2010.12
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[Cytokine role in diabetic neuropathy].
Mizukami H, Yagihashi S
Nihon rinsho. Japanese journal of clinical medicine 68 Suppl 9 563 - 7 2010.11
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A case of splenic follicular dendritic cell sarcoma, inflammatory pseudotumor-like variant
TAKAHASHI Kazunori, YAJIMA Nobuhisa, NAKAYAMA Yoshihito, MIZUKAMI Hiroki, WADA Ryuichi, ISHIGURO Ayako, GASA Fujihiko, YAGIHASHI Soroku
27 ( 3 ) 229 - 232 2010.7
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Serotonin regulates pancreatic beta cell mass during pregnancy.
Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, Fujitani Y, Kawamori R, Miyatsuka T, Kosaka Y, Yang K, Honig G, van der Hart M, Kishimoto N, Wang J, Yagihashi S, Tecott LH, Watada H, German MS
Nature medicine 16 ( 7 ) 804 - 8 2010.7
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The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice.
Yagihashi S, Mizukami H, Ogasawara S, Yamagishi S, Nukada H, Kato N, Hibi C, Chung S, Chung S
The Journal of pathology 220 ( 5 ) 530 - 41 2010.4
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Isolation of adipose tissue-derived mesenchymal stem cells and its effect of transplantation on the established stage of experimental diabetic neuropathy
MIZUKAMI Hiroki, YAMAGISHI Shin-ichiro, OGASAWARA Saori, INABA Wataru, YAGIHASHI Soroku
20 ( 2 ) 207 - 208 2009.12
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Small cell carcinoma with skeletal muscle differentiation of urinary bladder
YAJIMA Nobuhisa, MIZUKAMI Hiroki, WADA Ryuichi, SAITO Fumitada, YAGIHASHI Soroku
Pathology international 59 ( 10 ) 748 - 751 2009.10
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Small cell carcinoma with skeletal muscle differentiation of urinary bladder.
Yajima N, Mizukami H, Wada R, Saito F, Yagihashi S
Pathology international 59 ( 10 ) 748 - 51 2009.10
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Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma.
Shirasaki T, et. al.
BMC Cancer 8 ( 11 ) 348 - 359 2008.11
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Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma.
Shirasaki T, Maruya S, Mizukami H, Kakehata S, Kurotaki H, Yagihashi S, Shinkawa H
BMC cancer 8 348 2008.11
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Suppression of post-prandial hyperglycaemia by pioglitazone improved islet fibrosis and macrophage migration in the Goto-Kakizaki rat.
Mizukami H, et al.
Diabetes, obesity & metabolism 10 ( 9 ) 791 - 794 2008.9
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自然発症糖尿病GKラットの糖代謝・膵島病変に対するピタバスタチンの作用
水上浩哉 他
PROGRESS IN MEDICINE 28 ( 4 ) 999 - 1006 2008.4
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Augmented beta cell loss and mitochondrial abnormalities in sucrose-fed GK rats.
Mizukami H, et al.
Virchows Archiv 452 ( 4 ) 383 - 92 2008.4
-
Augmented beta cell loss and mitochondrial abnormalities in sucrose-fed GK rats.
Mizukami H, Wada R, Koyama M, Takeo T, Suga S, Wakui M, Yagihashi S
Virchows Archiv : an international journal of pathology 452 ( 4 ) 383 - 92 2008.4
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Correction of protein kinase C activity and macrophage migration in peripheral nerve by pioglitazone, peroxisome proliferator activated-gamma-ligand, in insulin-deficient diabetic rats.
Yamagishi S, Ogasawara S, Mizukami H, Yajima N, Wada R, Sugawara A, Yagihashi S
Journal of neurochemistry 104 ( 2 ) 491 - 9 2008.1
-
Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells.
Takeda I, Maruya S, Shirasaki T, Mizukami H, Takahata T, Myers JN, Kakehata S, Yagihashi S, Shinkawa H
Cancer science 98 ( 6 ) 890 - 9 2007.6
-
"jointly worked"
98 ( 6 ) 890 - 899 2007.4
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Implication of proinfl ammatory reactions in pathogenesis of diabetic microvascular complications
Yagihashi Soroku, Yamagishi Shin-ichiro, Mizukami Hiroki, Wada Ryuichi
弘前医学 59 ( 0 ) S101 - 108 2007
-
Novel mechanism of chronic exposure of oleic acid-induced insulin release impairment in rat pancreatic beta-cells.
Kudo T, et al.
The Journal of pharmacology and experimental therapeutics 318 ( 3 ) 1203 - 1210 2006.9
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Novel mechanism of chronic exposure of oleic acid-induced insulin release impairment in rat pancreatic beta-cells.
Kudo T, Wu J, Ogawa Y, Suga S, Hasegawa N, Suda T, Mizukami H, Yagihashi S, Wakui M
The Journal of pharmacology and experimental therapeutics 318 ( 3 ) 1203 - 10 2006.9
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Ganglioside GM3 promotes cell migration by regulating MAPK and c-Fos/AP-1.
Hashiramoto A, et al.
Oncogene 25 ( 28 ) 3948 - 3955 2006.6
-
Pancreatic malignant fibrous histiocytoma, inflammatory myofibroblastic tumor, and inflammatory pseudotumor related to autoimmune pancreatitis
Mizukami H, et al.
Virchows Archiv : an international journal of pathology 448 ( 5 ) 552 - 560 2006.5
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Pancreatic malignant fibrous histiocytoma, inflammatory myofibroblastic tumor, and inflammatory pseudotumor related to autoimmune pancreatitis: characterization and differential diagnosis.
Mizukami H, Yajima N, Wada R, Matsumoto K, Kojima M, Klöppel G, Yagihashi S
Virchows Archiv : an international journal of pathology 448 ( 5 ) 552 - 60 2006.5
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Aortic Valve Perforation Due to Latent Infective Endocarditis
MUNAKATA Mamoru, ITAYA Hiroyuki, MIZUKAMI Hiroki, ONO Yuichi
日本胸部外科学会雑誌 = The Japanese journal of thoracic and cardiovascular surgery 54 ( 2 ) 67 - 69 2006.2
-
Aortic valve perforation due to latent infective endocarditis.
Munakata M, et al.
The Japanese journal of thoracic and cardiovascular surgery 54 ( 2 ) 67 - 69 2006.2
-
Spindle cell metaplasia arising in thyroid adenoma: characterization of its pathology and differential diagnosis.
Shikama Y, et al.
Journal of Endocrinological Investigation 29 ( 2 ) 168 - 171 2006.2
-
Aortic valve perforation due to latent infective endocarditis.
Munakata M, Itaya H, Mizukami H, Ono Y
The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 54 ( 2 ) 67 - 9 2006.2
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Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix.
Yajima N, et. al.
Human pathology 36 ( 11 ) 1217 - 1225 2005.11
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Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix.
Yajima N, Wada R, Yamagishi S, Mizukami H, Itabashi C, Yagihashi S
Human pathology 36 ( 11 ) 1217 - 25 2005.11
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Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions.
Yamashita T, et. al.
Proceedings of the National Academy of Sciences of the United States of America 102 ( 8 ) 2725 - 2730 2005.2
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Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions.
Yamashita T, Wu YP, Sandhoff R, Werth N, Mizukami H, Ellis JM, Dupree JL, Geyer R, Sandhoff K, Proia RL
Proceedings of the National Academy of Sciences of the United States of America 102 ( 8 ) 2725 - 30 2005.2
-
Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease
Wu YP, et. al.
Molecular Genetics and Metabolism 84 ( 1 ) 9 - 17 2005.1
-
Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease.
Wu YP, Mizukami H, Matsuda J, Saito Y, Proia RL, Suzuki K
Molecular genetics and metabolism 84 ( 1 ) 9 - 17 2005.1
-
Global gene expression in a type 2 Gaucher disease brain
Myerowitz R, et. al.
MOLECULAR GENETICS AND METABOLISM 83 ( 4 ) 288 - 296 2004.12
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Global gene expression in a type 2 Gaucher disease brain.
Myerowitz R, Mizukami H, Richardson KL, Finn LS, Tifft CJ, Proia RL
Molecular genetics and metabolism 83 ( 4 ) 288 - 96 2004.12
-
New Perspectives on the Pathogenesis and Treatment of Diabetic Neuropathy
YAGIHASHI Soroku, WADA Ryuichi, YAMAGISHI Shin-Ichiro, MIZUKAMI Hiroki
15 ( 1 ) 1 - 16 2004.6
-
Enhanced insulin sensitivity in mice lacking ganglioside GM3
Yamashita T, et. al.
Proceedings of the National Academy of Sciences of the United States of America 100 ( 6 ) 3445 - 3449 2003.3
-
Enhanced insulin sensitivity in mice lacking ganglioside GM3.
Yamashita T, Hashiramoto A, Haluzik M, Mizukami H, Beck S, Norton A, Kono M, Tsuji S, Daniotti JL, Werth N, Sandhoff R, Sandhoff K, Proia RL
Proceedings of the National Academy of Sciences of the United States of America 100 ( 6 ) 3445 - 9 2003.3
-
Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles.
Miura K, Bowman ED, Simon R, Peng AC, Robles AI, Jones RT, Katagiri T, He P, Mizukami H, Charboneau L, Kikuchi T, Liotta LA, Nakamura Y, Harris CC
Cancer research 62 ( 11 ) 3244 - 50 2002.6
-
Molecular pathophysiology in Tay-Sachs and Sandhoff diseases as revealed by gene expression profiling.
Myerowitz R, Lawson D, Mizukami H, Mi Y, Tifft CJ, Proia RL
Human molecular genetics 11 ( 11 ) 1343 - 50 2002.5
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Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage.
Mizukami H, Mi Y, Wada R, Kono M, Yamashita T, Liu Y, Werth N, Sandhoff R, Sandhoff K, Proia RL
The Journal of clinical investigation 109 ( 9 ) 1215 - 21 2002.5