An autopsy case of incipient Pick's disease: immunohistochemical profile of early-stage Pick body formation.

Yasuo Miki, Fumiaki Mori, Kunikazu Tanji, Hidekachi Kurotaki, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Neuropathology : official journal of the Japanese Society of Neuropathology   34 ( 4 )   386 - 391   2014.8

Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.

Naoto Sugeno, Takafumi Hasegawa, Nobuyuki Tanaka, Mitsunori Fukuda, Koichi Wakabayashi, Ryuji Oshima, Masashi Konno, Emiko Miura, Akio Kikuchi, Toru Baba, Tadashi Anan, Mitsuyoshi Nakao, Sven Geisler, Masashi Aoki, Atsushi Takeda

The Journal of biological chemistry   289 ( 26 )   18137 - 18151   2014.6

Accumulation of the sigma-1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases.

Yasuo Miki, Fumiaki Mori, Tomoya Kon, Kunikazu Tanji, Yasuko Toyoshima, Mari Yoshida, Hidenao Sasaki, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Neuropathology : official journal of the Japanese Society of Neuropathology   34 ( 2 )   148 - 158   2014.4

FUS colocalizes with polyglutamine, but not with TDP-43 in neuronal intranuclear inclusions in spinocerebellar ataxia type 2.

F Mori, Y Toyoshima, K Tanji, A Kakita, H Takahashi, K Wakabayashi

Neuropathology and applied neurobiology   40 ( 3 )   351 - 355   2014.4

The kick-in system: a novel rapid knock-in strategy.

Yuko Tomonoh, Masanobu Deshimaru, Kimi Araki, Yasuhiro Miyazaki, Tomoko Arasaki, Yasuyoshi Tanaka, Haruna Kitamura, Fumiaki Mori, Koichi Wakabayashi, Sayaka Yamashita, Ryo Saito, Masayuki Itoh, Taku Uchida, Junko Yamada, Keisuke Migita, Shinya Ueno, Hiroki Kitaura, Akiyoshi Kakita, Christoph Lossin, Yukio Takano, Shinichi Hirose

PloS one   9 ( 2 )   e88549 - e88549   2014.2

Co-localization of Bunina bodies and TDP-43 inclusions in lower motor neurons in amyotrophic lateral sclerosis.

Fumiaki Mori, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Neuropathology : official journal of the Japanese Society of Neuropathology   34 ( 1 )   71 - 76   2014.2

ALS-associated protein FIG4 is localized in Pick and Lewy bodies, and also neuronal nuclear inclusions, in polyglutamine and intranuclear inclusion body diseases.

Tomoya Kon, Fumiaki Mori, Kunikazu Tanji, Yasuo Miki, Yasuko Toyoshima, Mari Yoshida, Hidenao Sasaki, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Neuropathology : official journal of the Japanese Society of Neuropathology   34 ( 1 )   19 - 26   2014.2

Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.

Kunikazu Tanji, Yasuo Miki, Taku Ozaki, Atsushi Maruyama, Hidemi Yoshida, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Acta neuropathologica communications   2   50 - 50   2014

Analysis of microRNA from archived formalin-fixed paraffin-embedded specimens of amyotrophic lateral sclerosis.

Koichi Wakabayashi, Fumiaki Mori, Akiyoshi Kakita, Hitoshi Takahashi, Jun Utsumi, Hidenao Sasaki

Acta neuropathologica communications   2   173 - 173   2014

[Multiple system atrophy and autophagy].

Koichi Wakabayashi, Kunikazu Tanji

Rinshō shinkeigaku = Clinical neurology   54 ( 12 )   966 - 968   2014

An autopsy case of preclinical multiple system atrophy (MSA-C).

Tomoya Kon, Fumiaki Mori, Kunikazu Tanji, Yasuo Miki, Koichi Wakabayashi

Neuropathology : official journal of the Japanese Society of Neuropathology   33 ( 6 )   667 - 672   2013.12

Valosin-containing protein immunoreactivity in tauopathies, synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease.

Fumiaki Mori, Kunikazu Tanji, Yasuko Toyoshima, Hidenao Sasaki, Mari Yoshida, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Neuropathology : official journal of the Japanese Society of Neuropathology   33 ( 6 )   637 - 644   2013.12

[Deposition and clearance of β-amyloid in the brain].

Koichi Wakabayashi, Yasuo Miki

Brain and nerve = Shinkei kenkyū no shinpo   65 ( 12 )   1433 - 1444   2013.12

[Cellular pathology of neurodegenerative disorders].

Koichi Wakabayashi

Rinshō shinkeigaku = Clinical neurology   53 ( 8 )   609 - 617   2013.8

Giant cell polymyositis and myocarditis associated with myasthenia gravis and thymoma.

Tomoya Kon, Fumiaki Mori, Kunikazu Tanji, Yasuo Miki, Tamaki Kimura, Koichi Wakabayashi

Neuropathology : official journal of the Japanese Society of Neuropathology   33 ( 3 )   281 - 287   2013.6

The Lewy body in Parkinson's disease and related neurodegenerative disorders.

Koichi Wakabayashi, Kunikazu Tanji, Saori Odagiri, Yasuo Miki, Fumiaki Mori, Hitoshi Takahashi

Molecular neurobiology   47 ( 2 )   495 - 508   2013.4

Brain expression level and activity of HDAC6 protein in neurodegenerative dementia.

Saori Odagiri, Kunikazu Tanji, Fumiaki Mori, Yasuo Miki, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Biochemical and biophysical research communications   430 ( 1 )   394 - 399   2013.1

Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases.

Kunikazu Tanji, Atsushi Maruyama, Saori Odagiri, Fumiaki Mori, Ken Itoh, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Journal of neuropathology and experimental neurology   72 ( 1 )   18 - 28   2013.1

[Pathology of corticobasal syndrome].

Koichi Wakabayashi, Yasuo Miki

Brain and Nerve = Shinkei kenkyū no shinpo   65 ( 1 )   9 - 18   2013.1

Salmon proteoglycan suppresses progression of mouse experimental autoimmune encephalomyelitis via regulation of Th17 and Foxp3(+) regulatory T cells.

Hiroshi Sashinami, Krisana Asano, Sayuri Yoshimura, Fumiaki Mori, Koichi Wakabayashi, Akio Nakane

Life sciences   91 ( 25-26 )   1263 - 1269   2012.12

Endosomal sorting related protein CHMP2B is localized in Lewy bodies and glial cytoplasmic inclusions in α-synucleinopathy.

Satoshi Tanikawa, Fumiaki Mori, Kunikazu Tanji, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Neuroscience letters   527 ( 1 )   16 - 21   2012.10

p62/sequestosome 1 binds to TDP-43 in brains with frontotemporal lobar degeneration with TDP-43 inclusions.

Kunikazu Tanji, Hai-Xin Zhang, Fumiaki Mori, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Journal of neuroscience research   90 ( 10 )   2034 - 2042   2012.10

Alteration of autophagosomal proteins in the brain of multiple system atrophy.

Kunikazu Tanji, Saori Odagiri, Atsushi Maruyama, Fumiaki Mori, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Neurobiology of disease   49C   190 - 198   2012.8

Autophagy-related proteins (p62, NBR1 and LC3) in intranuclear inclusions in neurodegenerative diseases.

Fumiaki Mori, Kunikazu Tanji, Saori Odagiri, Yasuko Toyoshima, Mari Yoshida, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Neuroscience letters   522 ( 2 )   134 - 138   2012.8

Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in α-synucleinopathy.

Saori Odagiri, Kunikazu Tanji, Fumiaki Mori, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Acta neuropathologica   124 ( 2 )   173 - 186   2012.8

Ubiquilin immunoreactivity in cytoplasmic and nuclear inclusions in synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease.

Fumiaki Mori, Kunikazu Tanji, Saori Odagiri, Yasuko Toyoshima, Mari Yoshida, Teruaki Ikeda, Hidenao Sasaki, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Acta neuropathologica   124 ( 1 )   149 - 151   2012.7

Abnormal tau deposition in neurons, but not in glial cells in the cerebral tissue surrounding arteriovenous malformation.

Tomoya Kon, Fumiaki Mori, Kunikazu Tanji, Yasuo Miki, Masahiko Tomiyama, Masayuki Baba, Yutaka Umehara, Hidekachi Kurotaki, Koichi Wakabayashi

Neuropathology : official journal of the Japanese Society of Neuropathology   32 ( 3 )   267 - 271   2012.6

FUS immunoreactivity of neuronal and glial intranuclear inclusions in intranuclear inclusion body disease.

F Mori, K Tanji, T Kon, S Odagiri, M Hattori, Y Hoshikawa, C Kono, K Yasui, S Yokoi, Y Hasegawa, M Yoshida, K Wakabayashi

Neuropathology and applied neurobiology   38 ( 4 )   322 - 328   2012.6

Immunohistochemical analysis of Marinesco bodies, using antibodies against proteins implicated in the ubiquitin-proteasome system, autophagy and aggresome formation.

Saori Odagiri, Kunikazu Tanji, Fumiaki Mori, Akiyoshi Kakita, Hitoshi Takahashi, Tetsu Kamitani, Koichi Wakabayashi

Neuropathology : official journal of the Japanese Society of Neuropathology   32 ( 3 )   261 - 266   2012.6

Ubiquitin-related proteins in neuronal and glial intranuclear inclusions in intranuclear inclusion body disease.

Fumiaki Mori, Kunikazu Tanji, Saori Odagiri, Manabu Hattori, Yasuko Hoshikawa, Chikao Kono, Keizo Yasui, Satoshi Yokoi, Yasuhiro Hasegawa, Tetsu Kamitani, Mari Yoshida, Koichi Wakabayashi

Pathology international   62 ( 6 )   407 - 411   2012.6

Dysfunction of extrasynaptic GABAergic transmission in PRIP-1 KO mice is associated with an epilepsy phenotype

Zhu G, Yoshida S, Migita K, Yamada J, Mori F, Tomiyama M, Wakabayashi K, Kanematsu T, Hirata M, Kaneko S, Ueno S, Okada M

J Pharmacol Exp Ther   340   520 - 528   2012.3

Alpha-synuclein in the skin nerve of pure autonomic failure

Igari R, Wada M, Wakabayashi K, Kato T

Intern Med   50   3049 - 3050   2011.12

Unmyelinated axons are more vulnerable to degeneration than myelinated axons of the cardiac nerve in Parkinson’s disease

Orimo S, Uchihara T, Kanazawa T, Itoh Y, Wakabayashi K, Kakita A, Takahashi H

Neuropathol Appl Neurobiol   37   791 - 802   2011.12

Accumulation of histone deacetylase 6, an aggresome-related protein, is specific to Lewy bodies and glial cytoplasmic inclusions

Miki Y, Mori F, Tanji K, Kakita A, Takahashi H, Wakabayashi K

Neuropathology   31   561 - 568   2011.12

The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of alpha-synuclein

Hasegawa T, Konno M, Baba T, Sugeno N, Kikuchi A, Kobayashi M, Miura E, Tanaka N, Tamai K, Furukawa K, Arai H, Mori F, Wakabayashi K, Aoki M, Itoyama Y, Takeda A

PLoS ONE   6   e29460   2011.12

A case of anaplastic clear-cell ependymoma presenting with high erythropoietin concentration and 1p/19q deletions

Asano K, Kudo K, Mori F, Ohkuma H, Wakabayashi K

Brain Tumor Pathol   28   317 - 327   2011.10

Immunohistochemical study of microscopic globular bodies of normal human brain

Odagiri S, Mori F, Tanji K, Kuroda N, Wakabayashi K

Biomed Res   32   337 - 342   2011.10

Synphilin-1 binding protein NUB1 is colocalized with non-fibrillar, proteinase K-resistant alpha-synuclein to presynapses in Lewy body disease

Tanji K, Mori F, Kakita A, Takahashi H, Wakabayashi K

J Neuropathol Exp Neurol   70   879 - 889   2011.10

グリア細胞質内封入体（Glial cytoplasmic inclusion）

若林孝一

日本臨床   2011.10

Immunohistochemical study of microscopic globular bodies of normal human brain.

Saori Odagiri, Fumiaki Mori, Kunikazu Tanji, Naohito Kuroda, Koichi Wakabayashi

Biomedical research (Tokyo, Japan)   32 ( 5 )   337 - 342   2011.10

Alteration of autophagosomal protein (LC3, GABARAP and GATE-16) in Lewy body disease

Tanji K, Mori F, Kakita A, Takahashi H, Wakabayashi K

Neurobiol Dis   43   690 - 697   2011.9

パーキンソン病におけるシヌクレイン蓄積の神経病理

若林孝一

BIO Clinica   26   691 - 695   2011.8

Enhancement of native and phosphorylated TDP-43 immunoreactivity by proteinase K treatment following autoclave heating

Mori F, Tanji K, Kakita A, Takahashi H, Wakabayashi K

Neuropathology   31   401 - 404   2011.8

Novel pathogenic mutations and copy number variations in the VPS13A gene in patients with chorea-acanthocytosis

Tomiyasu A, Nakamura M, Ichiba M, Ueno S, Saiki S, Morimoto M, Kobal J, Kageyama Y, Inui T, Wakabayashi K, Yamada T, Kanemori Y, Jung HH, Tanaka H, Orimo S, Afawi Z, Blatt I, Aasly J, Ujike H, Babovic-Vuksanovic D, Josephs KA, Tohge R, Rodrigues GR, Dupre N, Yamada H, Yokochi F, Kotschet K, Takai T, Rudzinska M, Szczudilk A, Penco S, Fujiwara M, Tojo K, Sano A

Neuropsychiatric Genet   156B   620 - 631   2011.7

筋萎縮性側索硬化症とTDP43

森　文秋、丹治邦和、若林孝一

Cognition and Dementia   10   113 - 120   2011.4

Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy

Wakasaya Y, Kawarabayashi T, Watanabe M, Yamamoto-Watanabe Y, Takamura A, Kurata T, Murakami T, Abe K, Yamada K, Wakabayashi K, Sasaki A, Westaway D, St. George Hyslop P, Matsubara E, Shoji M

Neurosci Res   89   576 - 584   2011.4

病理診断に役立つ分子生物学. Ubiquitin（神経変性疾患等）:診断編

若林孝一

病理と臨床   29   456 - 460   2011.4

Incipient intranuclear inclusion body disease in a 78-year-old woman

Mori F, Miki Y, Tanji K, Ogura E, Yagihashi N, Jensen PH, Wakabayashi K

Neuropathology   31   188 - 193   2011.4

パーキンソン病の自律神経病理

若林孝一

自律神経   48   9 - 11   2011.1

パーキンソン病の病理

若林孝一

総合臨床   59   2363 - 2366   2010.12

Widespread occurrence of eosinophilic neuronal cytoplasmic inclusions in an asymptomatic adult: A novel ubiquitin-negative filamentous inclusion

Mori F, Miki Y, Tanji K, Kusumi T, Kijima H, Wakabayashi K

Neuropathology   30   648 - 653   2010.12

The phenotype spectrum of Japanese multiple system atrophy

Ozawa T, Tada M, Kakita A, Onodera O, Tada M, Ishihara T, Morita T, Shimohata T, Wakabayashi K, Takahashi H, Nishizawa M

J Neurol Neurosurg Psychiatry   81   1253 - 1255   2010.11

Role of interleukin-17A in cell-mediated protection against Staphylococcus aureus infection in mice immunized with the fibronectin-binding domain of clumping factor

Narita K, Hu D-L, Mori F, Wakabayashi K, Iwakura Y, Nakane A

Infect Immun   78   4234 - 4242   2010.10

黒質のメラニンと神経変性

若林孝一、森　文秋

Brain Medical   22   201 - 203   2010.9

パーキンソン病の病理：Braak仮説をどうとらえるか

若林孝一

カレントテラピー   28   792 - 796   2010.9

Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice

Tanji K, Mori F, Mimura J, Itoh K, Kakita A, Takahashi H, Wakabayashi K

Acta Neuropathol   120   145 - 154   2010.8

Progressive anterior operculum syndrome due to FTLD-TDP: A clinico-pathological investigation

Otsuki M, Nakagawa Y, Mori F, Tobioka H, Yoshida H, Tatezawa Y, Tanigawa T, Takahashi I, Yabe I, Sasaki H, Wakabayashi K

J Neurol   257   1148 - 1153   2010.7

パーキンソン病とレビー小体の病理

若林孝一

老年期認知症研究会誌   17   114 - 116   2010.7

Cystatin C immunoreactivity and neuronal degeneration in amyotrophic lateral sclerosis

Mori F, Tanji K, Miki Y, Wakabayashi K

Hirosaki Med J   61   211 - 214   2010.7

15-deoxy-Δ12,14-prostaglandin J2 modifies profiles of nuclear TDP-43 protein through direct binding: Implication for the pathogenesis of TDP-43 proteinopathy

Zhang H, Tanji K, Yoshida H, Hayakari M, Mori F, Wakabayashi K

Hirosaki Med J   61   204 - 210   2010.7

Pathology of neuro-glial alpha-synucleinopathy (Lewy body disease and multiple system atrophy)

Wakabayashi K, Miki Y, Tanji K, Mori F

Hirosaki Med J   61   80 - 88   2010.7

Nubopathies: NUB1-related neurodegenerative disease

Tanji K, Mori F, Wakabayashi K, Kamitani T

Hirosaki Med J   61   89 - 96   2010.7

Involvement of the peripheral nervous system in synucleinopathies, tauopathies and other neurodegenerative proteinopathies of the brain

Wakabayashi K, Mori F, Tanji K, Orimo S, Takahashi H

Acta Neuropathol   120 ( 1 )   1 - 12   2010.7

Relationship between Bunina bodies and TDP-43 inclusions in spinal anterior horn in amyotrophic lateral sclerosis

Mori F, Tanji K, Miki Y, Kakita A, Takahashi H, Wakabayashi K

Neuropathol Appl Neurobiol   36   345 - 352   2010.6

In vivo visualization of α-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy]benzoxazole positron emission tomography in multiple system atrophy

Kikuchi A, Takeda A, Okamura N, Tashiro M, Hasegawa T, Furumoto S, Kobayashi M, Sugeno N, Baba T, Miki Y, Mori F, Wakabayashi K, Funaki Y, Iwata R, Takahashi S, Fukuda H, Arai H, Kudo Y, Yanai K, Itoyama Y

Brain   133   1772 - 1778   2010.6

レビー小体の構造と構成成分

若林孝一

Brain Medical   22   139 - 145   2010.6

一酸化炭素中毒の脳

若林孝一

Brain Medical   22   109 - 111   2010.6

Subependymal injuries in anterior horns of lateral ventricles and saggital rotational acceleration applied to the head

Kuroda N, Kita T, Mimasaka S, Wakabayashi K

Rom J Leg Med   18   103 - 114   2010.6

TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson’s disease and dementia with Lewy bodies

Tanji K, Kamitani T, Mori F, Kakita A, Takahashi H, Wakabayashi K

Neurobiol Dis   38   210 - 218   2010.5

Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-12,14-prostaglandin J2

Zhang H, Tanji K, Yoshida H, Hayakari M, Shibata T, Mori F, Uchida K, Wakabayashi K

Exp Neurol   222   296 - 303   2010.4

Locked-in症候群

若林孝一

Brain Medical   22   5 - 7   2010.3

Chorea-acanthocytosis with upper motor neuron degeneration and 3419_3420 delCA and 3970_3973 delAGTC VPS13A mutations

Miki Y, Nishie M, Ichiba M, Nakamura M, Mori F, Ogawa M, Kaimori M, Sano A, Wakabayashi K

Acta Neuropathol   119   271 - 273   2010.2

Clinical availability of skin biopsy in the diagnosis of Parkinson’s disease

Miki Y, Tomiyama M, Ueno T, Haga R, Nishijima H, Suzuki C, Mori F, Kaimori M, Baba M, Wakabayashi K

Neurosci Lett   469   357 - 359   2010.1

脳出血の肉眼像

若林孝一

Brain Medical   2009   307 - 309   2009.12

Incidental Lewy body disease restricted to the heart and stellate ganglia

Miki Y, Mori F, Wakabayashi K, Kuroda N, Orimo S

Mov Disord   24   2299 - 2301   2009.11

Decreased cystatin C immunoreactivity in spinal motor neurons and astrocytes in amyotrophic lateral sclerosis

Mori F, Tanji K, Miki Y, Wakabayashi K

J Neuropathol Exp Neurol   68   1200 - 1206   2009.11

ヒトてんかん遺伝子を導入したてんかんモデル動物の開発：てんかんの分子病態の解析

岡田元宏、吉田淑子、兼子　直、上野伸哉、森　文秋、若林孝一、斎藤　亮、高野行夫、廣瀬伸一

てんかん治療研究振興財団研究年報   20   39 - 44   2009.8

Hippocampal sclerosis with four-repeat tau-positive round inclusions in the dentate gyrus: a new type of four-repeat tauopathy

Miki Y, Mori F, Hori E, Kaimori M, Wakabayashi K

Acta Neuropathol   117   713 - 718   2009.6

パーキンソン病-基礎・臨床研究のアップデート-. III.病理・病態　神経病理学的特徴　中枢神経

高橋　均、若林孝一

日本臨床   67   146 - 150   2009.6

パーキンソン病-基礎・臨床研究のアップデート-. III.病理・病態　神経病理学的特徴　末梢自律神経

若林孝一、高橋　均

日本臨床   67   151 - 155   2009.6

Distribution and progression of amyloid-beta deposits in the amygdale of the aged macaque monkey, and parallels with zinc distribution

Ichinohe N, Hayashi M, Wakabayashi K, Rockland KS

Neuroscience   159   1374 - 1383   2009.4

神経変性疾患

若林孝一

病理と臨床   27   295 - 301   2009.4

大脳基底核の病理学-神経変性疾患を中心に

若林孝一、丹治邦和、森　文秋

Brain Nerve   61   429 - 439   2009.4

CBDの病理

若林孝一

Clinical Neuroscience   27   307 - 310   2009.3

Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

Orimo et al.

Brain   131   642 - 650   2008.4