日本内科学会

Hepatic Macrophages Express Melanoma Differentiation-Associated Gene 5 in Nonalcoholic Steatohepatitis.

Kawaguchi S, Sakuraba H, Horiuchi M, Ding J, Matsumiya T, Seya K, Iino C, Endo T, Kikuchi H, Yoshida S, Hiraga H, Fukuda S, Imaizumi T

Inflammation   45 ( 1 )   343 - 355   2021年09月

Daily Brazilian green propolis intake elevates blood artepillin C levels in humans.

Ding J, Matsumiya T, Hayakari R, Shiba Y, Kawaguchi S, Seya K, Ueno K, Imaizumi T

Journal of the science of food and agriculture   101 ( 11 )   4855 - 4861   2021年08月

Expression of IFN-induced transmembrane protein 1 in glomerular endothelial cells.

Hashimoto S, Imaizumi T, Watanabe S, Aizawa T, Tsugawa K, Kawaguchi S, Seya K, Matsumiya T, Tanaka H

Pediatrics international : official journal of the Japan Pediatric Society   63 ( 9 )   1075 - 1081   2021年07月

Human aortic valve interstitial cells obtained from patients with aortic valve stenosis are vascular endothelial growth factor receptor 2 positive and contribute to ectopic calcification.

Liu X, Yu Z, Daitoku K, Fukuda I, Motomura S, Matsumiya T, Imaizumi T, Furukawa KI, Seya K

Journal of pharmacological sciences   145 ( 2 )   213 - 221   2021年02月

Podocyte sphingomyelin phosphodiesterase acid-like 3b decreases among children with idiopathic nephrotic syndrome.

Shojiro Watanabe, Koji Hirono, Tomomi Aizawa, Koji Tsugawa, Kensuke Joh, Tadaatsu Imaizumi, Hiroshi Tanaka

Clinical and experimental nephrology   25 ( 1 )   44 - 51   2021年01月

Tryptanthrin suppresses double-stranded RNA-induced CXCL10 expression via inhibiting the phosphorylation of STAT1 in human umbilical vein endothelial cells.

Shogo Kawaguchi, Hirotake Sakuraba, Hidezumi Kikuchi, Noriyuki Numao, Taka Asari, Hiroto Hiraga, Jiangli Ding, Tomoh Matsumiya, Kazuhiko Seya, Shinsaku Fukuda, Tadaatsu Imaizumi

Molecular immunology   129   32 - 38   2021年01月

PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes.

Masamichi Nakata, Michiko Shimada, Ikuyo Narita-Kinjo, Daiki Nagawa, Kazutaka Kitayama, Misato Hamadate, Naotake Miura, Masashi Nozaka, Yosuke Kawamura, Takeshi Fujita, Reiichi Murakami, Tadaatsu Imaizumi, Norio Nakamura, Hirofumi Tomita

In vivo (Athens, Greece)   35 ( 1 )   147 - 153   2021年01月

Human aortic valve interstitial cells obtained from patients with aortic valve stenosis are vascular endothelial growth factor receptor 2 positive and contribute to ectopic calcification

Liu X, Yu Z, Daitoku K, Fukuda I, Motomura S, Matsumiya T, Imaizumi T, Furukawa K-I, Seya K

J Pharmacol Sci   2021年

PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes.

Nakata M, Shimada M, Narita-Kinjo I, Nagawa D, Kitayama K, Hamadate M, Miura N, Nozaka M, Kawamura Y, Fujita T, Murakami R, Imaizumi T, Nakamura N, Tomita H

In vivo (Athens, Greece)   35 ( 1 )   147 - 153   2021年

Interleukin-6 via Toll-Like Receptor 3 Signaling Attenuates the Expression of Proinflammatory Chemokines in Human Podocytes.

Umetsu H, Watanabe S, Imaizumi T, Aizawa T, Tsugawa K, Kawaguchi S, Seya K, Matsumiya T, Tanaka H

Kidney & blood pressure research   46 ( 2 )   207 - 218   2021年

Inhibitory effect of anti-malarial agents on the expression of proinflammatory chemokines via Toll-like receptor 3 signaling in human glomerular endothelial cells.

Sato R, Imaizumi T, Aizawa T, Watanabe S, Tsugawa K, Kawaguchi S, Seya K, Matsumiya T, Tanaka H

Renal failure   43 ( 1 )   643 - 650   2021年

IFIT Proteins Are Involved in CXCL10 Expression in Human Glomerular Endothelial Cells Treated with a Toll-Like Receptor 3 Agonist.

Imaizumi T, Hashimoto S, Sato R, Umetsu H, Aizawa T, Watanabe S, Kawaguchi S, Matsumiya T, Seya K, Ding J, Tanaka H

Kidney & blood pressure research   46 ( 1 )   74 - 83   2020年12月

Toll-Like Receptor 3 as a Recurrence Risk Factor and a Potential Molecular Therapeutic Target in Colorectal Cancer.

Tatsuya Yoshida, Takuya Miura, Tomoh Matsumiya, Hidemi Yoshida, Hajime Morohashi, Yoshiyuki Sakamoto, Akira Kurose, Tadaatsu Imaizumi, Kenichi Hakamada

Clinical and experimental gastroenterology   13   427 - 438   2020年12月

Toll-Like Receptor 3 as a Recurrence Risk Factor and a Potential Molecular Therapeutic Target in Colorectal Cancer.

Yoshida T, Miura T, Matsumiya T, Yoshida H, Morohashi H, Sakamoto Y, Kurose A, Imaizumi T, Hakamada K

Clinical and experimental gastroenterology   13   427 - 438   2020年10月

Polyinosinic-Polycytidylic Acid Induces CXCL1 Expression in Cultured hCMEC/D3 Human Cerebral Microvascular Endothelial Cells.

Yuchen Li, Tadaatsu Imaizumi, Tomoh Matsumiya, Kazuhiko Seya, Shogo Kawaguchi, Jiangli Ding, Hiroki Ohkuma

Neuroimmunomodulation   27 ( 1 )   38 - 47   2020年08月

ISG56 is involved in CXCL10 expression induced by TLR3 signaling in BEAS-2B bronchial epithelial cells.

Toshihiro Shiratori, Tadaatsu Imaizumi, Koji Hirono, Shogo Kawaguchi, Tomoh Matsumiya, Kazuhiko Seya, Sadatomo Tasaka

Experimental lung research   46 ( 6 )   195 - 202   2020年06月

Correction to: Warfarin calcifies human aortic valve interstitial cells at high-phosphate conditions via pregnane X receptor.

Yu Z, Seya K, Chiyoya M, Daitoku K, Motomura S, Imaizumi T, Fukuda I, Furukawa KI

Journal of bone and mineral metabolism   38 ( 3 )   418 - 419   2020年05月

Polyinosinic-Polycytidylic Acid Induces CXCL1 Expression in Cultured hCMEC/D3 Human Cerebral Microvascular Endothelial Cells.

Li Y, Imaizumi T, Matsumiya T, Seya K, Kawaguchi S, Ding J, Ohkuma H

Neuroimmunomodulation   27 ( 1 )   1 - 10   2020年04月

Menaquinone-4 Accelerates Calcification of Human Aortic Valve Interstitial Cells in High-Phosphate Medium through PXR.

Yang W, Yu Z, Chiyoya M, Liu X, Daitoku K, Motomura S, Imaizumi T, Fukuda I, Furukawa KI, Tsuji M, Seya K

The Journal of pharmacology and experimental therapeutics   372 ( 3 )   277 - 284   2020年03月

Interferon-induced transmembrane protein 1 and Myxovirus resistance protein 1 are induced by polyinosinic-polycytidylic acid in cultured hCMEC/D3 human cerebral microvascular endothelial cells.

Tadaatsu Imaizumi, Urara Satake, Ruri Miyashita, Shogo Kawaguchi, Tomoh Matsumiya, Kazuhiko Seya, Jiangli Ding, Hiroshi Tanaka

Journal of neuroimmunology   337   577047 - 577047   2019年12月

Melanoma Differentiation-Associated Gene 5 Positively Modulates TNF-α-Induced CXCL10 Expression in Cultured HuH-7 and HLE Cells.

Shogo Kawaguchi, Hirotake Sakuraba, Toshihiro Haga, Tomoh Matsumiya, Kazuhiko Seya, Tetsu Endo, Naoya Sawada, Chikara Iino, Hidezumi Kikuchi, Hiroto Hiraga, Shinsaku Fukuda, Tadaatsu Imaizumi

Inflammation   42 ( 6 )   2095 - 2104   2019年12月

Endothelial expression of fractalkine (CX3CL1) is induced by Toll-like receptor 3 signaling in cultured human glomerular endothelial cells.

Koji Hirono, Tadaatsu Imaizumi, Tomomi Aizawa, Shojiro Watanabe, Koji Tsugawa, Toshihiro Shiratori, Shogo Kawaguchi, Kazuhiko Seya, Tomoh Matsumiya, Etsuro Ito, Hiroshi Tanaka

Modern rheumatology   1 - 8   2019年11月

Endothelial expression of fractalkine (CX3CL1) is induced by Toll-like receptor 3 signaling in cultured human glomerular endothelial cells.

Hirono K, Imaizumi T, Aizawa T, Watanabe S, Tsugawa K, Shiratori T, Kawaguchi S, Seya K, Matsumiya T, Ito E, Tanaka H

Modern rheumatology   30 ( 6 )   1 - 8   2019年11月

Effect of low-concentration amyloid-β 1–42 (Aβ42) on human neuroblastoma SH-SY5Y cell viability: neuriproteictive potential of combination use with carnosic acid, rebamipide, edaravone, and resveratrol

Yoshida H, Hashimoto Y, Fukushima T, Tanji K, Matsumiya T, Seya K, Kawaguchi S, Imaizumi T

Hirosaki Medical Journal   70   24 - 38   2019年11月

Warfarin calcifies human aortic valve interstitial cells at high-phosphate conditions via pregnane X receptor.

Zaiqiang Yu, Kazuhiko Seya, Mari Chiyoya, Kazuyuki Daitoku, Shigeru Motomura, Tadaatsu Imaizumi, Ikuo Fukuda, Ken-Ichi Furukawa

Journal of bone and mineral metabolism   37 ( 6 )   944 - 956   2019年11月

Chloroquine attenuates TLR3-mediated plasminogen activator inhibitor-1 expression in cultured human glomerular endothelial cells.

Aizawa T, Imaizumi T, Hirono K, Watanabe S, Tsugawa K, Tanaka H

Clinical and experimental nephrology   23 ( 4 )   448 - 454   2019年04月

Retinoic Acid-Inducible Gene-i and CXCL10 are Involved in Biliary Atresia

弘前医学   69 ( 1-4 )   86 - 94   2019年03月

Retinoic acid-inducible gene-I and CXCL10 are involved in biliary atresia.

Kimura T, Imaizumi T, Yoshida T, Shimada T, Hayakari R, Kawaguchi S, Yoshida H., Kobayashi T, Hirabayashi T, Mizukami H, Kijima H, Hakamada K.

Hirosaki Medical Journal   2019年

Induction of CCL2 via TLR3 signaling in hCMEC/D3 cells: possible regulation by NF-B.

Sassa N, Hirono K, Shiratori T, Kawaguchi S, Matsumiya T, Yoshida H, Seya K, Tanaka H, Imaizumi T.

clinical and experimental neuroimmunology   2019年

Cytosolic Sensors of Viral RNA Are Involved in the Production of Interleukin-6 via Toll-Like Receptor 3 Signaling in Human Glomerular Endothelial Cells.

Qiang Liu, Tadaatsu Imaizumi, Tomomi Aizawa, Koji Hirono, Shogo Kawaguchi, Shojiro Watanabe, Koji Tsugawa, Tomoh Matsumiya, Kazuhiko Seya, Hidemi Yoshida, Hiroshi Tanaka

Kidney & blood pressure research   44 ( 1 )   62 - 71   2019年

Cytosolic Sensors of Viral RNA Are Involved in the Production of Interleukin-6 via Toll-Like Receptor 3 Signaling in Human Glomerular Endothelial Cells.

Liu Q, Imaizumi T, Aizawa T, Hirono K, Kawaguchi S, Watanabe S, Tsugawa K, Matsumiya T, Seya K, Yoshida H, Tanaka H

Kidney & blood pressure research   44 ( 1 )   62 - 71   2019年

Effect of low-concentration amyloid-β 1–42 (Aβ42) on human neuroblastoma SH-SY5Y cell viability: neuroprotective potential of combination use with carnosic acid, rebamipide, edaravone, and resveratrol

Yoshida Hidemi, Hashimoto Yuko, Fukushima Takashi, Tanji Kunikazu, Matsumiya Tomoh, Seya Kazuhiko, Kawaguchi Shogo, Imaizumi Tadaatsu

Hirosaki Medical Journal   70 ( 1 )   24 - 38   2019年

Interferon-stimulated gene 60 (ISG60) constitutes a negative feedback loop in the downstream of TLR3 signaling in hCMEC/D3 cells.

Tadaatsu Imaizumi, Naoko Sassa, Shogo Kawaguchi, Tomoh Matsumiya, Hidemi Yoshida, Kazuhiko Seya, Toshihiro Shiratori, Koji Hirono, Hiroshi Tanaka

Journal of neuroimmunology   324   16 - 21   2018年11月

Chloroquine attenuates TLR3-mediated plasminogen activator inhibitor-1 expression in cultured human glomerular endothelial cells.

Tomomi Aizawa, Tadaatsu Imaizumi, Koji Hirono, Shojiro Watanabe, Koji Tsugawa, Hiroshi Tanaka

Clinical and experimental nephrology   2018年10月

Gnetin C suppresses double-stranded RNA-induced C-C motif chemokine ligand 2 (CCL2) and CCL5 production by inhibiting Toll-like receptor 3 signaling pathway.

Hidemi Yoshida, Tadaatsu Imaizumi, Tomoh Matsumiya, Kazuhiko Seya, Shogo Kawaguchi, Hiroshi Tanaka

Biomedical research (Tokyo, Japan)   39 ( 5 )   231 - 240   2018年10月

The Essential Role of Double-Stranded RNA-Dependent Antiviral Signaling in the Degradation of Nonself Single-Stranded RNA in Nonimmune Cells.

Sayaka Kimura, Tomoh Matsumiya, Yuko Shiba, Michi Nakanishi, Ryo Hayakari, Shogo Kawaguchi, Hidemi Yoshida, Tadaatsu Imaizumi

Journal of immunology (Baltimore, Md. : 1950)   201 ( 3 )   1044 - 1052   2018年08月

Retinoic acid-inducible gene-I, melanoma differentiation-associated gene 5 and CXCL10 are induced by a TLR3 agonist in human brain microvascular endothelial cells.

Imaizumi T, Arai A, Kawaguchi S, Hayakari R, Matsumiya T, Seya K, Yoshida H, Tanaka H.

clinical and experimental neuroimmunology   9   189 - 97   2018年08月

Gnetin C, a resveratrol dimer, reduces amyloid-β 1-42 (Aβ42) production and ameliorates Aβ42-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells.

Syota Seino, Takeru Kimoto, Hidemi Yoshida, Kunikazu Tanji, Tomoh Matsumiya, Ryo Hayakari, Kazuhiko Seya, Shogo Kawaguchi, Kazushi Tsuruga, Hiroshi Tanaka, Tadaatsu Imaizumi

Biomedical research (Tokyo, Japan)   39 ( 3 )   105 - 115   2018年06月

Matrix Gla protein negatively regulates calcification of human aortic valve interstitial cells isolated from calcified aortic valves.

Mari Chiyoya, Kazuhiko Seya, Zaiqiang Yu, Kazuyuki Daitoku, Shigeru Motomura, Tadaatsu Imaizumi, Ikuo Fukuda, Ken-Ichi Furukawa

Journal of pharmacological sciences   136 ( 4 )   257 - 265   2018年04月

Toll-Like Receptor 3 Signaling Contributes to Regional Neutrophil Recruitment in Cultured Human Glomerular Endothelial Cells.

Qiang Liu, Tadaatsu Imaizumi, Shogo Kawaguchi, Tomomi Aizawa, Tomoh Matsumiya, Shojiro Watanabe, Koji Tsugawa, Hidemi Yoshida, Kazushi Tsuruga, Kensuke Joh, Hiroshi Kijima, Hiroshi Tanaka

Nephron   139 ( 4 )   349 - 358   2018年

Expression of CCL5 is induced by polyinosinic-polycytidylic acid in cultured hCMEC/D3 human brain microvascular endothelial cells

Arai A, Imaizumi T, et al.

Clinical and Experimental Neuroimmunology   2017年10月

DEC1 negatively regulates the expression of CXCL10 and CCL5 induced by poly IC in normal human mesangial cells.

Liu Q, Imaizumi T., et al

Biomedical Research   2017年08月

DEC1 promotes hypoxia-induced epithelial-mesenchymal transition (EMT) in human hepatocellular carcinoma cells.

Murakami K, Imaizumi T., et al.

Biomedical Research   2017年08月

Cylindromatosis (CYLD), a deubiquitinase, attenuates inflammatory signaling pathway by activating Toll-like receptor 3 in human mesangial cells.

Imaizumi T, Hayakari Y., et al.

Kidney & blood pressure research   2017年08月

CCL5 is induced by TLR3 signaling in HuCCT1 human bile duct carcinoma cells: possible involvement in the pathogenesis of biliary atresia.

Shimada T, Imaizumi T, et al

Biomedical Research   2017年08月

Urinary excretion of SMPDL-3b in children with intractable nephrotic syndrome.

Watanabe S, Imaizumi T., et al

Pediatrics international   2017年07月

Rebamipide reduces amyloid-β 1–42 (Aβ42) production and ameliorates Aβ43-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells.

Fukui K., Imaizumi T., et al

Neuroscience research   2017年06月

Clarithromycin attenuates the expression of monocyte chemoattractant protein-1 by activating toll-like receptor 4 in human mesangial cells.

Koji Tsugawa, Tadaatsu Imaizumi, Shojiro Watanabe, Kazushi Tsuruga, Hidemi Yoshida, Hiroshi Tanaka

Clinical and experimental nephrology   2017年04月

Simultaneous measurement of adenosine 3’,5’-cyclic monophosphate and guanosine 3’,5’-cyclic monophosphate in biological samples.

Seya K., Imaizumi T., et al.

Hirosaki Medical Journal   2017年04月

Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-β-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.

Kyogo Shirai, Taku Shimada, Hidemi Yoshida, Ryo Hayakari, Tomoh Matsumiya, Kunikazu Tanji, Manabu Murakami, Hiroshi Tanaka, Tadaatsu Imaizumi

Brain research   1658   60 - 67   2017年03月

Chloroquine attenuates TLR3/IFN-β signaling in cultured normal human mesangial cells: A possible protective effect against renal damage in lupus nephritis.

Tadaatsu Imaizumi, Ryo Hayakari, Tomoh Matsumiya, Hidemi Yoshida, Kazushi Tsuruga, Shojiro Watanabe, Shogo Kawaguchi, Hiroshi Tanaka

Modern rheumatology   1 - 18   2017年02月

Regression of atherosclerosis with apple procyanidins by activating the ATP-binding cassette subfamily A member 1 in a rabbit model.

Liang Wang, Toshio Fumoto, Saeko Masumoto, Toshihiko Shoji, Tomisato Miura, Masato Naraoka, Naoya Matsuda, Tadaatsu Imaizumi, Hiroki Ohkuma

Atherosclerosis   258   56 - 64   2017年01月

Critical Role of IRF-3 in the Direct Regulation of dsRNA-Induced Retinoic Acid-Inducible Gene-I (RIG-I) Expression.

Ryo Hayakari, Tomoh Matsumiya, Fei Xing, Hidemi Yoshida, Makoto Hayakari, Tadaatsu Imaizumi

PloS one   11 ( 9 )   e0163520 - e0163520   2016年09月

Desferrioxamine, an iron chelator, induces CXCL8 expression in U373MG Human astrocytoma cells.

Onda K, Yoshida H, Hayakari R, Xing F, Wang L, Matsumiya T, Kawaguchi S, Murakami M, Imaizumi T.

Hirosaki Med J   2016年06月

Clock gene expressions are altered by co-culture of gingival fibroblasts and oral cancer cells.

Furudate K, Matsumiya T, Hayakari R, Xing F, Kubota K, Sakaki H, Tamura Y, Kijima H, Imaizumi T, Kobayashi W.

Hirosaki Med J   2016年06月

The cardiorespiratory responses to inhalation and pentobarbital anesthesia in the mouse.

Han C, Ogata Y, Niwa H, Kushikata T, Watanabe H, Imaizumi T, Hirota K, Ono K, Ohba T, Murakami M.

Hirosaki Med J   2016年06月

Interferon-stimulated gene 15, a type I interferon-dependent transcript, is involved in the negative feedback loop regulating inflammatory cascades via Toll-like receptor 3 activation in human mesangial cells.

Imaizumi T, Shimada M, 他

Nephron Experimental Nephrol   2016年02月

Modified sympathetic nerve regulation in AKAP5-null mice.

Chong Han, Hirofumi Tomita, Takayoshi Ohba, Kimitaka Nishizaki, Yoshiki Ogata, Yasushi Matsuzaki, Daisuke Sawamura, Teruyuki Yanagisawa, Tomohiro Osanai, Tadaatsu Imaizumi, Atsushi Matsubara, Takeshi Adachi, Kyoichi Ono, Ken Okumura, Manabu Murakami

Biochemical and biophysical research communications   469 ( 4 )   897 - 902   2016年01月

Alteration of Antiviral Signalling by Single Nucleotide Polymorphisms (SNPs) of Mitochondrial Antiviral Signalling Protein (MAVS).

Fei Xing, Tomoh Matsumiya, Ryo Hayakari, Hidemi Yoshida, Shogo Kawaguchi, Ippei Takahashi, Shigeyuki Nakaji, Tadaatsu Imaizumi

PloS one   11 ( 3 )   e0151173 - e0151173   2016年

Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells.

Tadaatsu Imaizumi, Chikashi Yano, Akiko Numata, Koji Tsugawa, Ryo Hayakari, Tomoh Matsumiya, Hidemi Yoshida, Shojiro Watanabe, Kazushi Tsuruga, Shogo Kawaguchi, Manabu Murakami, Hiroshi Tanaka

Kidney & blood pressure research   41 ( 5 )   635 - 642   2016年

Non-Canonical Role of IKKα in the Regulation of STAT1 Phosphorylation in Antiviral Signaling.

Fei Xing, Tomoh Matsumiya, Yuko Shiba, Ryo Hayakari, Hidemi Yoshida, Tadaatsu Imaizumi

PloS one   11 ( 12 )   e0168696 - e0168696   2016年

Expressions of mRNA for innate immunity-associated functional molecules in urinary sediment in immunoglobulin A nephropathy.

Kazushi Tsuruga, Tomomi Aizawa, Shojiro Watanabe, Koji Tsugawa, Hidemi Yoshida, Tadaatsu Imaizumi, Etsuro Ito, Hiroshi Tanaka

Nephrology (Carlton, Vic.)   20 ( 12 )   916 - 921   2015年12月

Retinoic acid-inducible gene-I-like receptor (RLR)-mediated antiviral innate immune responses in the lower respiratory tract: Roles of TRAF3 and TRAF5.

Yuki Chiba, Tomoh Matsumiya, Tsugumi Satoh, Ryo Hayakari, Ken Furudate, Fei Xing, Hidemi Yoshida, Kunikazu Tanji, Hiroki Mizukami, Tadaatsu Imaizumi, Etsuro Ito

Biochemical and biophysical research communications   467 ( 2 )   191 - 196   2015年11月

Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.

Kunikazu Tanji, Yasuo Miki, Atsushi Maruyama, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Koichi Wakabayashi

Biochemical and biophysical research communications   465 ( 4 )   746 - 752   2015年10月

Interferon-stimulated gene (ISG) 60, as well as ISG56 and ISG54, positively regulates TLR3/IFN-β/STAT1 axis in U373MG human astrocytoma cells.

Tadaatsu Imaizumi, Hidemi Yoshida, Ryo Hayakari, Fei Xing, Lian Wang, Tomoh Matsumiya, Kunikazu Tanji, Shogo Kawaguchi, Manabu Murakami, Hiroshi Tanaka

Neuroscience research   2015年09月

Involvement of the orexin system in sympathetic nerve regulation.

Manabu Murakami, Takayoshi Ohba, Testuya Kushikata, Hidetoshi Niwa, Akira Kurose, Tadaatsu Imaizumi, Hiroyuki Watanabe, Teruyuki Yanagisawa, Shigeyuki Nakaji, Kyoichi Ono, Kazuyoshi Hirota

Biochemical and biophysical research communications   460 ( 4 )   1076 - 1081   2015年05月

Mizoribine in the treatment of pediatric-onset glomerular disease.

Hiroshi Tanaka, Kazushi Tsuruga, Taddatsu Imaizumi

World journal of pediatrics : WJP   11 ( 2 )   108 - 112   2015年05月

Desferrioxamine, an iron chelator, inhibits CXCL10 expression induced by polyinosinic-polycytidylic acid in U373MG human astrocytoma cells.

Tadaatsu Imaizumi, Nina Sakashita, Yasuaki Mushiga, Hidemi Yoshida, Ryo Hayakari, Fei Xing, Liang Wang, Tomoh Matsumiya, Kunikazu Tanji, Yuki Chiba, Ken Furudate, Shogo Kawaguchi, Manabu Murakami, Hiroshi Tanaka

Neuroscience research   94   10 - 16   2015年05月

Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells.

Pengfei Meng, Hidemi Yoshida, Kunikazu Tanji, Tomoh Matsumiya, Fei Xing, Ryo Hayakari, Liang Wang, Kazushi Tsuruga, Hiroshi Tanaka, Junsei Mimura, Kunio Kosaka, Ken Itoh, Ippei Takahashi, Shogo Kawaguchi, Tadaatsu Imaizumi

Neuroscience research   94   1 - 9   2015年05月

Effect of isoflurane inhalation anesthesia on mouse ECG

Shintaku T, Ohba T, Imaizumi T 他

Hirosaki Medical Journal   2015年04月

Tumor necrosis factor-α synergistically enhances polyinosinic-polycytidylic acid-induced toll-like receptor 3 signaling in cultured normal human mesangial cells: possible involvement in the pathogenesis of lupus nephritis.

Tadaatsu Imaizumi, Tomomi Aizawa, Ryo Hayakari, Fei Xing, Pengfei Meng, Kazushi Tsuruga, Tomoh Matsumiya, Hidemi Yoshida, Liang Wang, Tetsuya Tatsuta, Hiroshi Tanaka

Clinical and experimental nephrology   19 ( 1 )   75 - 81   2015年02月

Toll-like receptor 3 signaling contributes to the expression of a neutrophil chemoattractant, CXCL1 in human mesangial cells.

Tadaatsu Imaizumi, Tomomi Aizawa, Chihiro Segawa, Michiko Shimada, Kazushi Tsuruga, Shogo Kawaguchi, Tomoh Matsumiya, Hidemi Yoshida, Kensuke Joh, Hiroshi Tanaka

Clinical and experimental nephrology   2014年12月

Tumor microenvironment and RIG-I signaling molecules in Epstein Barr virus-positive and -negative classical Hodgkin lymphoma of the elderly.

Tsugumi Satoh, Ryuichi Wada, Nobuhisa Yajima, Tadaatsu Imaizumi, Soroku Yagihashi

Journal of clinical and experimental hematopathology : JCEH   54 ( 1 )   75 - 84   2014年07月

Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.

Kunikazu Tanji, Yasuo Miki, Taku Ozaki, Atsushi Maruyama, Hidemi Yoshida, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Acta neuropathologica communications   2   50 - 50   2014年06月

Efficacy of mizoribine-tacrolimus-based induction therapy for pediatric lupus nephritis.

H Tanaka, T Aizawa, S Watanabe, E Oki, K Tsuruga, T Imaizumi

Lupus   23 ( 8 )   813 - 818   2014年03月

Role of type I- and type II-interferon in expression of melanoma differentiation-associated gene-5 in HSC-3 oral squamous carcinoma cells.

Tomoh Matsumiya, Ryo Hayakari, Norihiko Narita, Ryohei Ito, Takao Kon, Kosei Kubota, Hirotaka Sakaki, Hidemi Yoshida, Tadaatsu Imaizumi, Wataru Kobayashi, Hiroto Kimura

Biomedical research (Tokyo, Japan)   35 ( 1 )   9 - 16   2014年03月

Periosteum-derived cells respond to mechanical stretch and activate Wnt and BMP signaling pathways.

Ryohei Ito, Tomoh Matsumiya, Takao Kon, Norihiko Narita, Kosei Kubota, Hirotaka Sakaki, Taku Ozaki, Tadaatsu Imaizumi, Wataru Kobayashi, Hiroto Kimura

Biomedical research (Tokyo, Japan)   35 ( 1 )   69 - 79   2014年03月

Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells.

Hidemi Yoshida, Pengfei Meng, Tomoh Matsumiya, Kunikazu Tanji, Ryo Hayakari, Fei Xing, Liang Wang, Kazushi Tsuruga, Hiroshi Tanaka, Junsei Mimura, Kunio Kosaka, Ken Itoh, Ippei Takahashi, Tadaatsu Imaizumi

Neuroscience research   79   83 - 93   2014年02月

Mizoribine selectively attenuates monocyte chemoattractant protein-1 production in cultured human glomerular mesangial cell: a possible benefit of its use in the treatment of lupus nephritis.

Tomomi Aizawa, Tadaatsu Imaizumi, Kazushi Tsuruga, Shojiro Watanabe, Yuki Chiba, Tomoh Matsumiya, Hidemi Yoshida, Hiroshi Tanaka

Nephrology (Carlton, Vic.)   19 ( 1 )   47 - 52   2014年01月

The level of RECQL1 expression is a prognostic factor for epithelial ovarian cancer.

Yoko Matsushita, Yoshihito Yokoyama, Hidemi Yoshida, Yuki Osawa, Makito Mizunuma, Tatsuhiko Shigeto, Masayuki Futagami, Tadaastu Imaizumi, Hideki Mizunuma

Journal of ovarian research   7   107 - 107   2014年

Effects of propofol on electrocardiogram measures in mice.

Tomohiro Shintaku, Takayoshi Ohba, Hidetoshi Niwa, Tetsuya Kushikata, Kazuyoshi Hirota, Kyoichi Ono, Yasushi Matsuzaki, Tadaatsu Imaizumi, Kenji Kuwasako, Daisuke Sawamura, Manabu Murakami

Journal of pharmacological sciences   126 ( 4 )   351 - 358   2014年

4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression.

Ryosuke Tamura, Yoshihito Yokoyama, Hidemi Yoshida, Tadaatsu Imaizumi, Hideki Mizunuma

Journal of ovarian research   7   94 - 94   2014年

Glomerular expression of myxovirus resistance protein 1 in human mesangial cells: possible activation of innate immunity in the pathogenesis of lupus nephritis.

Shojiro Watanabe, Tadaatsu Imaizumi, Kazushi Tsuruga, Tomomi Aizawa, Tatsuya Ito, Tomoh Matsumiya, Hidemi Yoshida, Kensuke Joh, Etsuro Ito, Hiroshi Tanaka

Nephrology (Carlton, Vic.)   18 ( 12 )   833 - 837   2013年12月

TLR4 signaling induces retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 in mesangial cells.

Tadaatsu Imaizumi, Tomomi Aizawa-Yashiro, Shojiro Watanabe, Tomoh Matsumiya, Hidemi Yoshida, Tetsuya Tatsuta, Fei Xing, Pengfei Meng, Ryo Hayakari, Kazushi Tsuruga, Hiroshi Tanaka

Journal of nephrology   26 ( 5 )   886 - 893   2013年10月

Novel role for molecular transporter importin 9 in posttranscriptional regulation of IFN-ε expression.

Tomoh Matsumiya, Fei Xing, Masayuki Ebina, Ryo Hayakari, Tadaatsu Imaizumi, Hidemi Yoshida, Hideaki Kikuchi, Matthew K Topham, Kei Satoh, Diana M Stafforini

Journal of immunology (Baltimore, Md. : 1950)   191 ( 4 )   1907 - 1915   2013年08月

MDA5 and ISG56 mediate CXCL10 expression induced by toll-like receptor 4 activation in U373MG human astrocytoma cells.

Tadaatsu Imaizumi, Keishu Murakami, Kasumi Ohta, Hirotaka Seki, Tomoh Matsumiya, Pengfei Meng, Ryo Hayakari, Fei Xing, Tomomi Aizawa-Yashiro, Tetsuya Tatsuta, Hidemi Yoshida, Hiroshi Kijima

Neuroscience research   76 ( 4 )   195 - 206   2013年08月

How are STAT1 and cholesterol metabolism associated in antiviral responses?

Tomoh Matsumiya, Tadaatsu Imaizumi

JAK-STAT   2 ( 3 )   e24189 - e24189   2013年07月

Urinary fractalkine and monocyte chemoattractant protein-1 as possible predictors of disease activity of childhood glomerulonephritis.

Tomomi Aizawa, Tadaatsu Imaizumi, Kazushi Tsuruga, Shojiro Watanabe, Hidemi Yoshida, Naonori Kumagai, Etsuro Ito, Hiroshi Tanaka

The Tohoku journal of experimental medicine   231 ( 4 )   265 - 270   2013年04月

Interaction between interferon-stimulated gene 56 and melanoma differentiation-associated gene 5 in Toll-like receptor 3 signaling in normal human mesangial cells.

Tadaatsu Imaizumi, Tomomi Aizawa-Yashiro, Tomoh Matsumiya, Hidemi Yoshida, Shojiro Watanabe, Kazushi Tsuruga, Tetsuya Tatsuta, Fei Xing, Ryo Hayakari, Pengfei Meng, Hiroshi Tanaka

American journal of nephrology   37 ( 2 )   118 - 125   2013年02月

Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.

Pengfei Meng, Hidemi Yoshida, Tomoh Matsumiya, Tadaatsu Imaizumi, Kunikazu Tanji, Fei Xing, Ryo Hayakari, Junichi Dempoya, Tetsuya Tatsuta, Tomomi Aizawa-Yashiro, Junsei Mimura, Kunio Kosaka, Ken Itoh, Kei Satoh

Neuroscience research   75 ( 2 )   94 - 102   2013年02月

Glomerular expression of fractalkine is induced by polyinosinic-polycytidylic acid in human mesangial cells: possible involvement of fractalkine after viral infection.

Tomomi Aizawa-Yashiro, Tadaatsu Imaizumi, Kazushi Tsuruga, Shojiro Watanabe, Tomoh Matsumiya, Ryo Hayakari, Hidemi Yoshida, Kei Satoh, Etsuro Ito, Hiroshi Tanaka

Pediatric research   73 ( 2 )   180 - 186   2013年02月

Effects of Brazilian green propolis on double-stranded RNA-mediated induction of interferon-inducible gene and inhibition of recruitment of polymorphonuclear cells.

Ryo Hayakari, Tomoh Matsumiya, Fei Xing, Janeth C Tayone, Junichi Dempoya, Tetsuya Tatsuta, Tomomi Aizawa-Yashiro, Tadaatsu Imaizumi, Hidemi Yoshida, Kei Satoh

Journal of the science of food and agriculture   93 ( 3 )   646 - 651   2013年02月

Inflammatory chemokine expression via Toll-like receptor 3 signaling in normal human mesangial cells.

Hiroshi Tanaka, Tadaatsu Imaizumi

Clinical & developmental immunology   2013   984708 - 984708   2013年02月

Treatment of young patients with lupus nephritis using calcineurin inhibitors.

Hiroshi Tanaka, Kazushi Tsuruga, Tomomi Aizawa-Yashiro, Shojiro Watanabe, Tadaatsu Imaizumi

World journal of nephrology   1 ( 6 )   177 - 183   2012年12月

Double-stranded RNA induces biphasic STAT1 phosphorylation by both type I interferon (IFN)-dependent and type I IFN-independent pathways.

Junichi Dempoya, Tomoh Matsumiya, Tadaatsu Imaizumi, Ryo Hayakari, Fei Xing, Hidemi Yoshida, Ken Okumura, Kei Satoh

Journal of virology   86 ( 23 )   12760 - 12769   2012年12月

Foreign RNA induces the degradation of mitochondrial antiviral signaling protein (MAVS): the role of intracellular antiviral factors.

Fei Xing, Tomoh Matsumiya, Koji Onomoto, Ryo Hayakari, Tadaatsu Imaizumi, Hidemi Yoshida, Mitsutoshi Yoneyama, Takashi Fujita, Kei Satoh

PloS one   7 ( 9 )   e45136 - e45136   2012年09月

Expression of melanoma differentiation associated gene 5 is increased in human gastric mucosa infected with Helicobacter pylori.

Tetsuya Tatsuta, Tadaatsu Imaizumi, Tadashi Shimoyama, Manabu Sawaya, Tanji Kunikazu, Tomoh Matsumiya, Hidemi Yoshida, Kei Satoh, Shinsaku Fukuda

Journal of clinical pathology   65 ( 9 )   839 - 843   2012年09月

Melanoma differentiation-associated gene 5 regulates the expression of a chemokine CXCL10 in human mesangial cells: implications for chronic inflammatory renal diseases.

Tadaatsu Imaizumi, Tomomi Aizawa-Yashiro, Kazushi Tsuruga, Hiroshi Tanaka, Tomoh Matsumiya, Hidemi Yoshida, Tetsuya Tatsuta, Fei Xing, Ryo Hayakari, Kei Satoh

The Tohoku journal of experimental medicine   228 ( 1 )   17 - 26   2012年08月

Characterization of retinoic acid-inducible gene-I (RIG-I) expression corresponding to viral infection and UVB in human keratinocytes

Kimura K, Matsuzaki Y, Nishikawa Y, Kitamura H, Akasaka E, Rokunohe D, Nakano H, Imaizumi T, Satoh K, Sawamura D.:

Journal of Dermatological Science   66 ( 1 )   66 - 70   2012年01月

Imbalance towards Th1 pathway predominance in purpura neohritis with proteinuria.

Tsuruga K, Watanabe S, Oki E, Aizawa-Yashiro T, Yoshida H, Imaizumi T, Ito E, Tanaka H:

Pediatric Nephrology   26   2253 - 2258   2011年12月

Polyinosinic-polycytidylic acid induces the expression of interferon-stimulated gene 20 in mesangial cells

Imaizumi T, Tanaka H, et al

Nephron Experimental Nephrology   119 ( 2 )   e40 - e48   2011年08月

Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells.

Okabayashi T, Kojima T, Masaki T, Yokota S, Imaizumi T, et al

Virus Research   160 ( 1-2 )   360 - 366   2011年07月

PERIOD1(PWE1) has anti-apoptptic effects, and PER3 has pro-apoptotic effects during ciaplatin (CDDP) treatment in human gingival cancer CA9-22 cells.

Sato F, Wu Y, Bhawal UK, Liu Y, Imaizumi T, et al

European journal of Cancer   47 ( 11 )   1747 - 1758   2011年07月

Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation

Yoshida H, Mumura J, Imaizumi T, et al.

Neuroscience Research   69   291 - 298   2011年04月

Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation.

Yoshida H, Metoki N, Ishikawa A, Imaizumi T, Matsumiya T, Tanji K, Ota K, Ohyama C, Satoh K

Neuroscience Research   66 ( 3 )   284 - 289   2010年03月

Interferon-α2b induces p21cip1/waf1 degradation and cell proliferation in HeLa cells.

Ota K, Matsumiya T, Sakuraba H, Imaizumi T, Yoshida H, Kawaguchi S, Fukuda S, Satoh K

Cell Cycle   9 ( 1 )   131 - 139   2010年01月

PERIOD1 (PER1) is an anti-apoptotic factor in human pancreatic and hepatic cancer cells

Sato F, Nagata C, Liu Y, Suzuki T, Kondo J, Morohashi S, Imaizumi T, Kato Y, Kijima H:

Journal of Biochemistry   146 ( 6 )   833 - 838   2009年12月

The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection.

Papon L, Oteiza A, Imaizumi T, Kato H, Brocchi E, Lawson TG, Akira S, Mechti N.

Virology   393 ( 2 )   311 - 318   2009年10月

Metformin restores impaired HDL-mediated cholesterol efflux due to glycation.

Matsuki K, Tamasawa N, Yamashita M, Tanabe J, Murakami H, Imaiuzmi T, Satoh K, Suda T

Atherosclerosis   206 ( 2 )   434 - 438   2009年10月

Retinoic acid-inducible gene-I is constitutively expressed and involved in IFN-gamma-stimulated CXCL9-11 production in intestinal epithelial cells

Kawaguchi S, Ishiguro Y, Imaizumi T, et al.

Immunology Letters   123 ( 1 )   9 - 13   2009年03月

The levels of retinoic acid-incuble gene-I are regulated by heat shock protein 90-alpha.

Matsumiya T, Imaizumi T, et al.

Journal of Immunology   182 ( 5 )   2717 - 2725   2009年03月

Tumor-necrosis factor-alpha induces retinoic acid-inducible gene-I in rheumatoid fibroblast-like synoviocytes

Imaizumi T. et al.

Immunology letters   122 ( 1 )   89 - 93   2009年01月

Involvement of retinoic acid-inducible gene-I (RIG-I) in inflammation of rheumatoid fibroblast-like synoviocytes.(共著)

Imaizumi T., et al.

Clinical and Experimental Immunology   153 ( 7 )   240 - 244   2008年07月

Retinoic aci-inducible gene-I is induced by interferon-gamma and regulates CXCL11 expression in HeLa cells

Yuzawa E, Imaizumi T, et al.

Life Sciences   82 ( 1 )   672 - 675   2008年03月

Expression of mRNA for functional molecules in urinary sediment in glomerulonephritis

Tsugawa K, Suzuki K, Oki E, Imaizumi T, et al.

Pediatric Nephrology   23 ( 3 )   395 - 401   2008年03月

Basic-helix-loop (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression

Sato F, Bhawal U, Kawamoto T, Fujimoto K, Imaizumi T, et al.

Genes to Cells   13 ( 2 )   131 - 144   2008年02月

Negative feedback regulation of RIG-I-mediated anti-viral signaling by interferon-induced ISG15 conjugation

Kim MJ, Hwang SY, Imaizumi T, et al.

Journal of Virology   82 ( 3 )   1474 - 1483   2008年02月

Expression of interferon-stimulated gene 20 (ISG20) in vascular endothelial cells

Imaizumi T, Mechti N, et al.

Microbiology and Immunology   52 ( 1 )   30 - 35   2008年01月

Double-stranded RNA induces galectin-9 in vascular endothelial cells: involvement of TLR3, PI3K and IRF3 pathway.

Imaizumi T. et al.

Glycobiology   17 ( 7 )   12C - 15C   2007年07月

2019年度，特別教育科目（研究室研修），専門教育科目（学部）

2019年度，神経科学，専門教育科目（学部）

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2018年度，神経科学，専門教育科目（学部）

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