Papers - IMAIZUMI TADAATSU
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Corrigendum to "Elucidation of the inhibitory effect of (+)-hopeaphenol on polyinosinicepolycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells" [Journal of Pharmacological Sciences 149 (2022) 147-157].
Xu L, Yu Z, Uekusa Y, Kawaguchi S, Kikuchi H, Daitoku K, Minakawa M, Motomura S, Furukawa KI, Oshima Y, Seya K, Imaizumi T
Journal of pharmacological sciences 151 ( 1 ) 63 - 64 2023.1
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ER export signals mediate plasma membrane localization of transmembrane protein TMEM72.
Jiangli Ding, Tomoh Matsumiya, Yasuo Miki, Ryo Hayakari, Yuko Shiba, Shogo Kawaguchi, Kazuhiko Seya, Tadaatsu Imaizumi
The FEBS journal 290 ( 10 ) 2636 - 2657 2022.12
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Glomerular endothelial expression of type I IFN-stimulated gene, DExD/H-Box helicase 60 via toll-like receptor 3 signaling: possible involvement in the pathogenesis of lupus nephritis.
Takao Karasawa, Riko Sato, Tadaatsu Imaizumi, Shun Hashimoto, Masashi Fujita, Tomomi Aizawa, Koji Tsugawa, Shogo Kawaguchi, Kazuhiko Seya, Kiminori Terui, Hiroshi Tanaka
Renal failure 44 ( 1 ) 137 - 145 2022.12
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Role of MDA5 in regulating CXCL10 expression induced by TLR3 signaling in human rheumatoid fibroblast-like synoviocytes.
Saruga T, Imaizumi T, Kawaguchi S, Seya K, Matsumiya T, Sasaki E, Sasaki N, Uesato R, Ishibashi Y:
Mol Biol Rep 48 ( 1 ) 425 - 433 2021.12
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Sphingomyelin Phosphodiesterase Acid-Like 3b is Essential for Toll-Like Receptor 3 Signaling in Human Podocytes.
Shojiro Watanabe, Umetsu Hidenori, Shun Hashimoto, Sato Riko, Tomomi Aizawa, Koji Tsugawa, Tadaatsu Imaizumi, Hiroshi Tanaka
The Journal of membrane biology 255 ( 1 ) 117 - 122 2021.11
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Hepatic Macrophages Express Melanoma Differentiation-Associated Gene 5 in Nonalcoholic Steatohepatitis.
Shogo Kawaguchi, Hirotake Sakuraba, Momone Horiuchi, Jiangli Ding, Tomoh Matsumiya, Kazuhiko Seya, Chikara Iino, Tetsu Endo, Hidezumi Kikuchi, Shukuko Yoshida, Hiroto Hiraga, Shinsaku Fukuda, Tadaatsu Imaizumi
Inflammation 45 ( 1 ) 343 - 355 2021.9
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Daily Brazilian green propolis intake elevates blood artepillin C levels in humans.
Jiangli Ding, Tomoh Matsumiya, Ryo Hayakari, Yuko Shiba, Shogo Kawaguchi, Kazuhiko Seya, Kayo Ueno, Tadaatsu Imaizumi
Journal of the science of food and agriculture 101 ( 11 ) 4855 - 4861 2021.8
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Expression of IFN‐induced transmembrane protein 1 in glomerular endothelial cells
Shun Hashimoto, Tadaatsu Imaizumi, Shojiro Watanabe, Tomomi Aizawa, Koji Tsugawa, Shogo Kawaguchi, Kazuhiko Seya, Tomoh Matsumiya, Hiroshi Tanaka
Pediatrics International 63 ( 9 ) 1075 - 1081 2021.7
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Human aortic valve interstitial cells obtained from patients with aortic valve stenosis are vascular endothelial growth factor receptor 2 positive and contribute to ectopic calcification.
Liu X, Yu Z, Daitoku K, Fukuda I, Motomura S, Matsumiya T, Imaizumi T, Furukawa KI, Seya K
Journal of pharmacological sciences 145 ( 2 ) 213 - 221 2021.2
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Podocyte sphingomyelin phosphodiesterase acid-like 3b decreases among children with idiopathic nephrotic syndrome.
Shojiro Watanabe, Koji Hirono, Tomomi Aizawa, Koji Tsugawa, Kensuke Joh, Tadaatsu Imaizumi, Hiroshi Tanaka
Clinical and experimental nephrology 25 ( 1 ) 44 - 51 2021.1
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Tryptanthrin suppresses double-stranded RNA-induced CXCL10 expression via inhibiting the phosphorylation of STAT1 in human umbilical vein endothelial cells.
Shogo Kawaguchi, Hirotake Sakuraba, Hidezumi Kikuchi, Noriyuki Numao, Taka Asari, Hiroto Hiraga, Jiangli Ding, Tomoh Matsumiya, Kazuhiko Seya, Shinsaku Fukuda, Tadaatsu Imaizumi
Molecular immunology 129 32 - 38 2021.1
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PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes.
Masamichi Nakata, Michiko Shimada, Ikuyo Narita-Kinjo, Daiki Nagawa, Kazutaka Kitayama, Misato Hamadate, Naotake Miura, Masashi Nozaka, Yosuke Kawamura, Takeshi Fujita, Reiichi Murakami, Tadaatsu Imaizumi, Norio Nakamura, Hirofumi Tomita
In vivo (Athens, Greece) 35 ( 1 ) 147 - 153 2021.1
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PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes
MASAMICHI NAKATA, MICHIKO SHIMADA, IKUYO NARITA-KINJO, DAIKI NAGAWA, KAZUTAKA KITAYAMA, MISATO HAMADATE, NAOTAKE MIURA, MASASHI NOZAKA, YOSUKE KAWAMURA, TAKESHI FUJITA, REIICHI MURAKAMI, TADAATSU IMAIZUMI, NORIO NAKAMURA, HIROFUMI TOMITA
In Vivo 35 ( 1 ) 147 - 153 2021
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Interleukin-6 via Toll-like receptor 3 signaling attenuates the expression of proinflammatory chemokines in human podocytes
Umetsu H, Watanabe S, Imaizumi T, Aizawa T, Tsugawa K, Kawaguchi S, Seya K, Matsumiya T, Tanaka H
Kidney Blood Pressure Res 46 ( 2 ) 207 - 218 2021
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Inhibitory effect of anti-malarial agents on the expression of proinflammatory chemokines via Toll-like receptor 3 signaling in human glomerular endothelial cells.
Sato R, Imaizumi T, Aizawa T, Watanabe S, Tsugawa K, Kawaguchi S, Seya K, Matsumiya T, Tanaka T
Renal Failure 43 ( 1 ) 643 - 650 2021
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Human aortic valve interstitial cells obtained from patients with aortic valve stenosis are vascular endothelial growth factor receptor 2 positive and contribute to ectopic calcification
Liu X, Yu Z, Daitoku K, Fukuda I, Motomura S, Matsumiya T, Imaizumi T, Furukawa K-I, Seya K
J Pharmacol Sci 2021
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IFIT Proteins Are Involved in CXCL10 Expression in Human Glomerular Endothelial Cells Treated with a Toll-Like Receptor 3 Agonist
Tadaatsu Imaizumi, Shun Hashimoto, Riko Sato, Hidenori Umetsu, Tomomi Aizawa, Shojiro Watanabe, Shogo Kawaguchi, Tomoh Matsumiya, Kazuhiko Seya, Jiangli Ding, Hiroshi Tanaka
Kidney and Blood Pressure Research 46 ( 1 ) 74 - 83 2020.12
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Toll-Like Receptor 3 as a Recurrence Risk Factor and a Potential Molecular Therapeutic Target in Colorectal Cancer.
Tatsuya Yoshida, Takuya Miura, Tomoh Matsumiya, Hidemi Yoshida, Hajime Morohashi, Yoshiyuki Sakamoto, Akira Kurose, Tadaatsu Imaizumi, Kenichi Hakamada
Clinical and experimental gastroenterology 13 427 - 438 2020.12
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<p>Toll-Like Receptor 3 as a Recurrence Risk Factor and a Potential Molecular Therapeutic Target in Colorectal Cancer</p>
Tatsuya Yoshida, Takuya Miura, Tomoh Matsumiya, Hidemi Yoshida, Hajime Morohashi, Yoshiyuki Sakamoto, Akira Kurose, Tadaatsu Imaizumi, Kenichi Hakamada
Clinical and Experimental Gastroenterology 13 427 - 438 2020.10
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Polyinosinic-Polycytidylic Acid Induces CXCL1 Expression in Cultured hCMEC/D3 Human Cerebral Microvascular Endothelial Cells.
Yuchen Li, Tadaatsu Imaizumi, Tomoh Matsumiya, Kazuhiko Seya, Shogo Kawaguchi, Jiangli Ding, Hiroki Ohkuma
Neuroimmunomodulation 27 ( 1 ) 38 - 47 2020.8
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ISG56 is involved in CXCL10 expression induced by TLR3 signaling in BEAS-2B bronchial epithelial cells.
Toshihiro Shiratori, Tadaatsu Imaizumi, Koji Hirono, Shogo Kawaguchi, Tomoh Matsumiya, Kazuhiko Seya, Sadatomo Tasaka
Experimental lung research 46 ( 6 ) 195 - 202 2020.6
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ISG56 is involved in CXCL10 expression induced by TLR3 signaling in BEAS-2B bronchial epithelial cells.
Toshihiro Shiratori, Tadaatsu Imaizumi, Koji Hirono, Shogo Kawaguchi, Tomoh Matsumiya, Kazuhiko Seya, Sadatomo Tasaka
Experimental lung research 46 ( 6 ) 1 - 8 2020.5
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Correction to: Warfarin calcifies human aortic valve interstitial cells at high-phosphate conditions via pregnane X receptor.
Yu Z, Seya K, Chiyoya M, Daitoku K, Motomura S, Imaizumi T, Fukuda I, Furukawa KI
Journal of bone and mineral metabolism 38 ( 3 ) 418 - 419 2020.5
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Polyinosinic-Polycytidylic Acid Induces CXCL1 Expression in Cultured hCMEC/D3 Human Cerebral Microvascular Endothelial Cells.
Yuchen Li, Tadaatsu Imaizumi, Tomoh Matsumiya, Kazuhiko Seya, Shogo Kawaguchi, Jiangli Ding, Hiroki Ohkuma
Neuroimmunomodulation 27 ( 1 ) 1 - 10 2020.4
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Menaquinone-4 Accelerates Calcification of Human Aortic Valve Interstitial Cells in High-Phosphate Medium through PXR.
Yang W, Yu Z, Chiyoya M, Liu X, Daitoku K, Motomura S, Imaizumi T, Fukuda I, Furukawa KI, Tsuji M, Seya K
The Journal of pharmacology and experimental therapeutics 372 ( 3 ) 277 - 284 2020.3
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Interferon-induced transmembrane protein 1 and Myxovirus resistance protein 1 are induced by polyinosinic-polycytidylic acid in cultured hCMEC/D3 human cerebral microvascular endothelial cells.
Tadaatsu Imaizumi, Urara Satake, Ruri Miyashita, Shogo Kawaguchi, Tomoh Matsumiya, Kazuhiko Seya, Jiangli Ding, Hiroshi Tanaka
Journal of neuroimmunology 337 577047 - 577047 2019.12
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Melanoma Differentiation-Associated Gene 5 Positively Modulates TNF-α-Induced CXCL10 Expression in Cultured HuH-7 and HLE Cells.
Shogo Kawaguchi, Hirotake Sakuraba, Toshihiro Haga, Tomoh Matsumiya, Kazuhiko Seya, Tetsu Endo, Naoya Sawada, Chikara Iino, Hidezumi Kikuchi, Hiroto Hiraga, Shinsaku Fukuda, Tadaatsu Imaizumi
Inflammation 42 ( 6 ) 2095 - 2104 2019.12
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Endothelial expression of fractalkine (CX3CL1) is induced by Toll-like receptor 3 signaling in cultured human glomerular endothelial cells.
Koji Hirono, Tadaatsu Imaizumi, Tomomi Aizawa, Shojiro Watanabe, Koji Tsugawa, Toshihiro Shiratori, Shogo Kawaguchi, Kazuhiko Seya, Tomoh Matsumiya, Etsuro Ito, Hiroshi Tanaka
Modern rheumatology 1 - 8 2019.11
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Endothelial expression of fractalkine (CX3CL1) is induced by Toll-like receptor 3 signaling in cultured human glomerular endothelial cells.
Koji Hirono, Tadaatsu Imaizumi, Tomomi Aizawa, Shojiro Watanabe, Koji Tsugawa, Toshihiro Shiratori, Shogo Kawaguchi, Kazuhiko Seya, Tomoh Matsumiya, Etsuro Ito, Hiroshi Tanaka
Modern rheumatology 30 ( 6 ) 1 - 8 2019.11
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Effect of low-concentration amyloid-β 1–42 (Aβ42) on human neuroblastoma SH-SY5Y cell viability: neuriproteictive potential of combination use with carnosic acid, rebamipide, edaravone, and resveratrol
Yoshida H, Hashimoto Y, Fukushima T, Tanji K, Matsumiya T, Seya K, Kawaguchi S, Imaizumi T
Hirosaki Medical Journal 70 24 - 38 2019.11
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Warfarin calcifies human aortic valve interstitial cells at high-phosphate conditions via pregnane X receptor.
Zaiqiang Yu, Kazuhiko Seya, Mari Chiyoya, Kazuyuki Daitoku, Shigeru Motomura, Tadaatsu Imaizumi, Ikuo Fukuda, Ken-Ichi Furukawa
Journal of bone and mineral metabolism 37 ( 6 ) 944 - 956 2019.11
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Chloroquine attenuates TLR3-mediated plasminogen activator inhibitor-1 expression in cultured human glomerular endothelial cells
Tomomi Aizawa, Tadaatsu Imaizumi, Koji Hirono, Shojiro Watanabe, Koji Tsugawa, Hiroshi Tanaka
Clinical and Experimental Nephrology 23 ( 4 ) 448 - 454 2019.4
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Retinoic Acid‐inducible Gene‐I and CXCL10 are Involved in Biliary Atresia
Kimura Toshiro, Imaizumi Tadaatsu, Yoshida Tatsuya, Shimada Taku, Hayakari Ryo, Kawaguchi Shogo, Yoshida Hidemi, Kobayashi Tamotsu, Hirabayashi Takeshi, Mizukami Hiroki, Kijima Hiroshi, Hakamada Kenichi
Hirosaki Medical Journal 69 ( 1-4 ) 86 - 94 2019.3
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Induction of CCL2 via TLR3 signaling in hCMEC/D3 cells: possible regulation by NF-B.
Sassa N, Hirono K, Shiratori T, Kawaguchi S, Matsumiya T, Yoshida H, Seya K, Tanaka H, Imaizumi T.
clinical and experimental neuroimmunology 2019
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Retinoic acid-inducible gene-I and CXCL10 are involved in biliary atresia.
Kimura T, Imaizumi T, Yoshida T, Shimada T, Hayakari R, Kawaguchi S, Yoshida H., Kobayashi T, Hirabayashi T, Mizukami H, Kijima H, Hakamada K.
Hirosaki Medical Journal 2019
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Cytosolic Sensors of Viral RNA Are Involved in the Production of Interleukin-6 via Toll-Like Receptor 3 Signaling in Human Glomerular Endothelial Cells.
Qiang Liu, Tadaatsu Imaizumi, Tomomi Aizawa, Koji Hirono, Shogo Kawaguchi, Shojiro Watanabe, Koji Tsugawa, Tomoh Matsumiya, Kazuhiko Seya, Hidemi Yoshida, Hiroshi Tanaka
Kidney & blood pressure research 44 ( 1 ) 62 - 71 2019
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Effect of low-concentration amyloid-β 1–42 (Aβ42) on human neuroblastoma SH-SY5Y cell viability: neuroprotective potential of combination use with carnosic acid, rebamipide, edaravone, and resveratrol
Yoshida Hidemi, Hashimoto Yuko, Fukushima Takashi, Tanji Kunikazu, Matsumiya Tomoh, Seya Kazuhiko, Kawaguchi Shogo, Imaizumi Tadaatsu
Hirosaki Medical Journal 70 ( 1 ) 24 - 38 2019
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Cytosolic Sensors of Viral RNA Are Involved in the Production of Interleukin-6 via Toll-Like Receptor 3 Signaling in Human Glomerular Endothelial Cells.
Qiang Liu, Tadaatsu Imaizumi, Tomomi Aizawa, Koji Hirono, Shogo Kawaguchi, Shojiro Watanabe, Koji Tsugawa, Tomoh Matsumiya, Kazuhiko Seya, Hidemi Yoshida, Hiroshi Tanaka
Kidney & blood pressure research 44 ( 1 ) 62 - 71 2019
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Induction of C-C motif chemokine ligand 2 through Toll-like receptor 3 signaling in human cerebral microvascular endothelial cell/D3 cells: possible regulation by nuclear factor-κB
Naoko Sassa, Koji Hirono, Toshihiro Shiratori, Shogo Kawaguchi, Tomoh Matsumiya, Hidemi Yoshida, Kazuhiko Seya, Hiroshi Tanaka, Tadaatsu Imaizumi
Clinical and Experimental Neuroimmunology 10 ( 3 ) 197 - 203 2019
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Interferon-stimulated gene 60 (ISG60) constitutes a negative feedback loop in the downstream of TLR3 signaling in hCMEC/D3 cells.
Tadaatsu Imaizumi, Naoko Sassa, Shogo Kawaguchi, Tomoh Matsumiya, Hidemi Yoshida, Kazuhiko Seya, Toshihiro Shiratori, Koji Hirono, Hiroshi Tanaka
Journal of neuroimmunology 324 16 - 21 2018.11
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Chloroquine attenuates TLR3-mediated plasminogen activator inhibitor-1 expression in cultured human glomerular endothelial cells.
Tomomi Aizawa, Tadaatsu Imaizumi, Koji Hirono, Shojiro Watanabe, Koji Tsugawa, Hiroshi Tanaka
Clinical and experimental nephrology 2018.10
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Gnetin C suppresses double-stranded RNA-induced C-C motif chemokine ligand 2 (CCL2) and CCL5 production by inhibiting Toll-like receptor 3 signaling pathway.
Hidemi Yoshida, Tadaatsu Imaizumi, Tomoh Matsumiya, Kazuhiko Seya, Shogo Kawaguchi, Hiroshi Tanaka
Biomedical research (Tokyo, Japan) 39 ( 5 ) 231 - 240 2018.10
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The Essential Role of Double-Stranded RNA-Dependent Antiviral Signaling in the Degradation of Nonself Single-Stranded RNA in Nonimmune Cells.
Sayaka Kimura, Tomoh Matsumiya, Yuko Shiba, Michi Nakanishi, Ryo Hayakari, Shogo Kawaguchi, Hidemi Yoshida, Tadaatsu Imaizumi
Journal of immunology (Baltimore, Md. : 1950) 201 ( 3 ) 1044 - 1052 2018.8
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Retinoic acid-inducible gene-I, melanoma differentiation-associated gene 5 and CXCL10 are induced by a TLR3 agonist in human brain microvascular endothelial cells.
Imaizumi T, Arai A, Kawaguchi S, Hayakari R, Matsumiya T, Seya K, Yoshida H, Tanaka H.
clinical and experimental neuroimmunology 9 189 - 97 2018.8
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Gnetin C, a resveratrol dimer, reduces amyloid-β 1-42 (Aβ42) production and ameliorates Aβ42-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells.
Syota Seino, Takeru Kimoto, Hidemi Yoshida, Kunikazu Tanji, Tomoh Matsumiya, Ryo Hayakari, Kazuhiko Seya, Shogo Kawaguchi, Kazushi Tsuruga, Hiroshi Tanaka, Tadaatsu Imaizumi
Biomedical research (Tokyo, Japan) 39 ( 3 ) 105 - 115 2018.6
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Matrix Gla protein negatively regulates calcification of human aortic valve interstitial cells isolated from calcified aortic valves.
Mari Chiyoya, Kazuhiko Seya, Zaiqiang Yu, Kazuyuki Daitoku, Shigeru Motomura, Tadaatsu Imaizumi, Ikuo Fukuda, Ken-Ichi Furukawa
Journal of pharmacological sciences 136 ( 4 ) 257 - 265 2018.4
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Toll-Like Receptor 3 Signaling Contributes to Regional Neutrophil Recruitment in Cultured Human Glomerular Endothelial Cells.
Qiang Liu, Tadaatsu Imaizumi, Shogo Kawaguchi, Tomomi Aizawa, Tomoh Matsumiya, Shojiro Watanabe, Koji Tsugawa, Hidemi Yoshida, Kazushi Tsuruga, Kensuke Joh, Hiroshi Kijima, Hiroshi Tanaka
Nephron 139 ( 4 ) 349 - 358 2018
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Expression of CCL5 is induced by polyinosinic-polycytidylic acid in cultured hCMEC/D3 human brain microvascular endothelial cells
Arai A, Imaizumi T, et al.
Clinical and Experimental Neuroimmunology 2017.10
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DEC1 negatively regulates the expression of CXCL10 and CCL5 induced by poly IC in normal human mesangial cells.
Liu Q, Imaizumi T., et al
Biomedical Research 2017.8
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DEC1 promotes hypoxia-induced epithelial-mesenchymal transition (EMT) in human hepatocellular carcinoma cells.
Murakami K, Imaizumi T., et al.
Biomedical Research 2017.8
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Cylindromatosis (CYLD), a deubiquitinase, attenuates inflammatory signaling pathway by activating Toll-like receptor 3 in human mesangial cells.
Imaizumi T, Hayakari Y., et al.
Kidney & blood pressure research 2017.8
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CCL5 is induced by TLR3 signaling in HuCCT1 human bile duct carcinoma cells: possible involvement in the pathogenesis of biliary atresia.
Shimada T, Imaizumi T, et al
Biomedical Research 2017.8
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Urinary excretion of SMPDL-3b in children with intractable nephrotic syndrome.
Watanabe S, Imaizumi T., et al
Pediatrics international 2017.7
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Rebamipide reduces amyloid-β 1–42 (Aβ42) production and ameliorates Aβ43-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells.
Fukui K., Imaizumi T., et al
Neuroscience research 2017.6
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Clarithromycin attenuates the expression of monocyte chemoattractant protein-1 by activating toll-like receptor 4 in human mesangial cells.
Koji Tsugawa, Tadaatsu Imaizumi, Shojiro Watanabe, Kazushi Tsuruga, Hidemi Yoshida, Hiroshi Tanaka
Clinical and experimental nephrology 2017.4
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Simultaneous measurement of adenosine 3’,5’-cyclic monophosphate and guanosine 3’,5’-cyclic monophosphate in biological samples.
Seya K., Imaizumi T., et al.
Hirosaki Medical Journal 2017.4
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Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-β-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.
Kyogo Shirai, Taku Shimada, Hidemi Yoshida, Ryo Hayakari, Tomoh Matsumiya, Kunikazu Tanji, Manabu Murakami, Hiroshi Tanaka, Tadaatsu Imaizumi
Brain research 1658 60 - 67 2017.3
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Chloroquine attenuates TLR3/IFN-β signaling in cultured normal human mesangial cells: A possible protective effect against renal damage in lupus nephritis.
Tadaatsu Imaizumi, Ryo Hayakari, Tomoh Matsumiya, Hidemi Yoshida, Kazushi Tsuruga, Shojiro Watanabe, Shogo Kawaguchi, Hiroshi Tanaka
Modern rheumatology 1 - 18 2017.2
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Regression of atherosclerosis with apple procyanidins by activating the ATP-binding cassette subfamily A member 1 in a rabbit model.
Liang Wang, Toshio Fumoto, Saeko Masumoto, Toshihiko Shoji, Tomisato Miura, Masato Naraoka, Naoya Matsuda, Tadaatsu Imaizumi, Hiroki Ohkuma
Atherosclerosis 258 56 - 64 2017.1
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Critical Role of IRF-3 in the Direct Regulation of dsRNA-Induced Retinoic Acid-Inducible Gene-I (RIG-I) Expression.
Ryo Hayakari, Tomoh Matsumiya, Fei Xing, Hidemi Yoshida, Makoto Hayakari, Tadaatsu Imaizumi
PloS one 11 ( 9 ) e0163520 - e0163520 2016.9
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Desferrioxamine, an iron chelator, induces CXCL8 expression in U373MG Human astrocytoma cells.
Onda K, Yoshida H, Hayakari R, Xing F, Wang L, Matsumiya T, Kawaguchi S, Murakami M, Imaizumi T.
Hirosaki Med J 2016.6
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Clock gene expressions are altered by co-culture of gingival fibroblasts and oral cancer cells.
Furudate K, Matsumiya T, Hayakari R, Xing F, Kubota K, Sakaki H, Tamura Y, Kijima H, Imaizumi T, Kobayashi W.
Hirosaki Med J 2016.6
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The cardiorespiratory responses to inhalation and pentobarbital anesthesia in the mouse.
Han C, Ogata Y, Niwa H, Kushikata T, Watanabe H, Imaizumi T, Hirota K, Ono K, Ohba T, Murakami M.
Hirosaki Med J 2016.6
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Interferon-stimulated gene 15, a type I interferon-dependent transcript, is involved in the negative feedback loop regulating inflammatory cascades via Toll-like receptor 3 activation in human mesangial cells.
Imaizumi T, Shimada M, 他
Nephron Experimental Nephrol 2016.2
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Modified sympathetic nerve regulation in AKAP5-null mice.
Chong Han, Hirofumi Tomita, Takayoshi Ohba, Kimitaka Nishizaki, Yoshiki Ogata, Yasushi Matsuzaki, Daisuke Sawamura, Teruyuki Yanagisawa, Tomohiro Osanai, Tadaatsu Imaizumi, Atsushi Matsubara, Takeshi Adachi, Kyoichi Ono, Ken Okumura, Manabu Murakami
Biochemical and biophysical research communications 469 ( 4 ) 897 - 902 2016.1
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Alteration of Antiviral Signalling by Single Nucleotide Polymorphisms (SNPs) of Mitochondrial Antiviral Signalling Protein (MAVS).
Fei Xing, Tomoh Matsumiya, Ryo Hayakari, Hidemi Yoshida, Shogo Kawaguchi, Ippei Takahashi, Shigeyuki Nakaji, Tadaatsu Imaizumi
PloS one 11 ( 3 ) e0151173 - e0151173 2016
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Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells.
Tadaatsu Imaizumi, Chikashi Yano, Akiko Numata, Koji Tsugawa, Ryo Hayakari, Tomoh Matsumiya, Hidemi Yoshida, Shojiro Watanabe, Kazushi Tsuruga, Shogo Kawaguchi, Manabu Murakami, Hiroshi Tanaka
Kidney & blood pressure research 41 ( 5 ) 635 - 642 2016
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Non-Canonical Role of IKKα in the Regulation of STAT1 Phosphorylation in Antiviral Signaling.
Fei Xing, Tomoh Matsumiya, Yuko Shiba, Ryo Hayakari, Hidemi Yoshida, Tadaatsu Imaizumi
PloS one 11 ( 12 ) e0168696 - e0168696 2016
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Expressions of mRNA for innate immunity-associated functional molecules in urinary sediment in immunoglobulin A nephropathy.
Kazushi Tsuruga, Tomomi Aizawa, Shojiro Watanabe, Koji Tsugawa, Hidemi Yoshida, Tadaatsu Imaizumi, Etsuro Ito, Hiroshi Tanaka
Nephrology (Carlton, Vic.) 20 ( 12 ) 916 - 921 2015.12
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Retinoic acid-inducible gene-I-like receptor (RLR)-mediated antiviral innate immune responses in the lower respiratory tract: Roles of TRAF3 and TRAF5.
Yuki Chiba, Tomoh Matsumiya, Tsugumi Satoh, Ryo Hayakari, Ken Furudate, Fei Xing, Hidemi Yoshida, Kunikazu Tanji, Hiroki Mizukami, Tadaatsu Imaizumi, Etsuro Ito
Biochemical and biophysical research communications 467 ( 2 ) 191 - 196 2015.11
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Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.
Kunikazu Tanji, Yasuo Miki, Atsushi Maruyama, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Koichi Wakabayashi
Biochemical and biophysical research communications 465 ( 4 ) 746 - 752 2015.10
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Interferon-stimulated gene (ISG) 60, as well as ISG56 and ISG54, positively regulates TLR3/IFN-β/STAT1 axis in U373MG human astrocytoma cells.
Tadaatsu Imaizumi, Hidemi Yoshida, Ryo Hayakari, Fei Xing, Lian Wang, Tomoh Matsumiya, Kunikazu Tanji, Shogo Kawaguchi, Manabu Murakami, Hiroshi Tanaka
Neuroscience research 2015.9
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Involvement of the orexin system in sympathetic nerve regulation.
Manabu Murakami, Takayoshi Ohba, Testuya Kushikata, Hidetoshi Niwa, Akira Kurose, Tadaatsu Imaizumi, Hiroyuki Watanabe, Teruyuki Yanagisawa, Shigeyuki Nakaji, Kyoichi Ono, Kazuyoshi Hirota
Biochemical and biophysical research communications 460 ( 4 ) 1076 - 1081 2015.5
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Mizoribine in the treatment of pediatric-onset glomerular disease.
Hiroshi Tanaka, Kazushi Tsuruga, Taddatsu Imaizumi
World journal of pediatrics : WJP 11 ( 2 ) 108 - 112 2015.5
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Desferrioxamine, an iron chelator, inhibits CXCL10 expression induced by polyinosinic-polycytidylic acid in U373MG human astrocytoma cells.
Tadaatsu Imaizumi, Nina Sakashita, Yasuaki Mushiga, Hidemi Yoshida, Ryo Hayakari, Fei Xing, Liang Wang, Tomoh Matsumiya, Kunikazu Tanji, Yuki Chiba, Ken Furudate, Shogo Kawaguchi, Manabu Murakami, Hiroshi Tanaka
Neuroscience research 94 10 - 16 2015.5
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Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells.
Pengfei Meng, Hidemi Yoshida, Kunikazu Tanji, Tomoh Matsumiya, Fei Xing, Ryo Hayakari, Liang Wang, Kazushi Tsuruga, Hiroshi Tanaka, Junsei Mimura, Kunio Kosaka, Ken Itoh, Ippei Takahashi, Shogo Kawaguchi, Tadaatsu Imaizumi
Neuroscience research 94 1 - 9 2015.5
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Effect of isoflurane inhalation anesthesia on mouse ECG
Shintaku T, Ohba T, Imaizumi T 他
Hirosaki Medical Journal 2015.4
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Tumor necrosis factor-α synergistically enhances polyinosinic-polycytidylic acid-induced toll-like receptor 3 signaling in cultured normal human mesangial cells: possible involvement in the pathogenesis of lupus nephritis.
Tadaatsu Imaizumi, Tomomi Aizawa, Ryo Hayakari, Fei Xing, Pengfei Meng, Kazushi Tsuruga, Tomoh Matsumiya, Hidemi Yoshida, Liang Wang, Tetsuya Tatsuta, Hiroshi Tanaka
Clinical and experimental nephrology 19 ( 1 ) 75 - 81 2015.2
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Toll-like receptor 3 signaling contributes to the expression of a neutrophil chemoattractant, CXCL1 in human mesangial cells.
Tadaatsu Imaizumi, Tomomi Aizawa, Chihiro Segawa, Michiko Shimada, Kazushi Tsuruga, Shogo Kawaguchi, Tomoh Matsumiya, Hidemi Yoshida, Kensuke Joh, Hiroshi Tanaka
Clinical and experimental nephrology 2014.12
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Tumor microenvironment and RIG-I signaling molecules in Epstein Barr virus-positive and -negative classical Hodgkin lymphoma of the elderly.
Tsugumi Satoh, Ryuichi Wada, Nobuhisa Yajima, Tadaatsu Imaizumi, Soroku Yagihashi
Journal of clinical and experimental hematopathology : JCEH 54 ( 1 ) 75 - 84 2014.7
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Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.
Kunikazu Tanji, Yasuo Miki, Taku Ozaki, Atsushi Maruyama, Hidemi Yoshida, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi
Acta neuropathologica communications 2 50 - 50 2014.6
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Efficacy of mizoribine-tacrolimus-based induction therapy for pediatric lupus nephritis.
H Tanaka, T Aizawa, S Watanabe, E Oki, K Tsuruga, T Imaizumi
Lupus 23 ( 8 ) 813 - 818 2014.3
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Role of type I- and type II-interferon in expression of melanoma differentiation-associated gene-5 in HSC-3 oral squamous carcinoma cells.
Tomoh Matsumiya, Ryo Hayakari, Norihiko Narita, Ryohei Ito, Takao Kon, Kosei Kubota, Hirotaka Sakaki, Hidemi Yoshida, Tadaatsu Imaizumi, Wataru Kobayashi, Hiroto Kimura
Biomedical research (Tokyo, Japan) 35 ( 1 ) 9 - 16 2014.3
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Periosteum-derived cells respond to mechanical stretch and activate Wnt and BMP signaling pathways.
Ryohei Ito, Tomoh Matsumiya, Takao Kon, Norihiko Narita, Kosei Kubota, Hirotaka Sakaki, Taku Ozaki, Tadaatsu Imaizumi, Wataru Kobayashi, Hiroto Kimura
Biomedical research (Tokyo, Japan) 35 ( 1 ) 69 - 79 2014.3
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Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells.
Hidemi Yoshida, Pengfei Meng, Tomoh Matsumiya, Kunikazu Tanji, Ryo Hayakari, Fei Xing, Liang Wang, Kazushi Tsuruga, Hiroshi Tanaka, Junsei Mimura, Kunio Kosaka, Ken Itoh, Ippei Takahashi, Tadaatsu Imaizumi
Neuroscience research 79 83 - 93 2014.2
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Mizoribine selectively attenuates monocyte chemoattractant protein-1 production in cultured human glomerular mesangial cell: a possible benefit of its use in the treatment of lupus nephritis.
Tomomi Aizawa, Tadaatsu Imaizumi, Kazushi Tsuruga, Shojiro Watanabe, Yuki Chiba, Tomoh Matsumiya, Hidemi Yoshida, Hiroshi Tanaka
Nephrology (Carlton, Vic.) 19 ( 1 ) 47 - 52 2014.1
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The level of RECQL1 expression is a prognostic factor for epithelial ovarian cancer.
Yoko Matsushita, Yoshihito Yokoyama, Hidemi Yoshida, Yuki Osawa, Makito Mizunuma, Tatsuhiko Shigeto, Masayuki Futagami, Tadaastu Imaizumi, Hideki Mizunuma
Journal of ovarian research 7 107 - 107 2014
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Effects of propofol on electrocardiogram measures in mice.
Tomohiro Shintaku, Takayoshi Ohba, Hidetoshi Niwa, Tetsuya Kushikata, Kazuyoshi Hirota, Kyoichi Ono, Yasushi Matsuzaki, Tadaatsu Imaizumi, Kenji Kuwasako, Daisuke Sawamura, Manabu Murakami
Journal of pharmacological sciences 126 ( 4 ) 351 - 358 2014
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4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression.
Ryosuke Tamura, Yoshihito Yokoyama, Hidemi Yoshida, Tadaatsu Imaizumi, Hideki Mizunuma
Journal of ovarian research 7 94 - 94 2014
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Glomerular expression of myxovirus resistance protein 1 in human mesangial cells: possible activation of innate immunity in the pathogenesis of lupus nephritis.
Shojiro Watanabe, Tadaatsu Imaizumi, Kazushi Tsuruga, Tomomi Aizawa, Tatsuya Ito, Tomoh Matsumiya, Hidemi Yoshida, Kensuke Joh, Etsuro Ito, Hiroshi Tanaka
Nephrology (Carlton, Vic.) 18 ( 12 ) 833 - 837 2013.12
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TLR4 signaling induces retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 in mesangial cells.
Tadaatsu Imaizumi, Tomomi Aizawa-Yashiro, Shojiro Watanabe, Tomoh Matsumiya, Hidemi Yoshida, Tetsuya Tatsuta, Fei Xing, Pengfei Meng, Ryo Hayakari, Kazushi Tsuruga, Hiroshi Tanaka
Journal of nephrology 26 ( 5 ) 886 - 893 2013.10
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Novel role for molecular transporter importin 9 in posttranscriptional regulation of IFN-ε expression.
Tomoh Matsumiya, Fei Xing, Masayuki Ebina, Ryo Hayakari, Tadaatsu Imaizumi, Hidemi Yoshida, Hideaki Kikuchi, Matthew K Topham, Kei Satoh, Diana M Stafforini
Journal of immunology (Baltimore, Md. : 1950) 191 ( 4 ) 1907 - 1915 2013.8
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MDA5 and ISG56 mediate CXCL10 expression induced by toll-like receptor 4 activation in U373MG human astrocytoma cells.
Tadaatsu Imaizumi, Keishu Murakami, Kasumi Ohta, Hirotaka Seki, Tomoh Matsumiya, Pengfei Meng, Ryo Hayakari, Fei Xing, Tomomi Aizawa-Yashiro, Tetsuya Tatsuta, Hidemi Yoshida, Hiroshi Kijima
Neuroscience research 76 ( 4 ) 195 - 206 2013.8
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How are STAT1 and cholesterol metabolism associated in antiviral responses?
Tomoh Matsumiya, Tadaatsu Imaizumi
JAK-STAT 2 ( 3 ) e24189 - e24189 2013.7
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Urinary fractalkine and monocyte chemoattractant protein-1 as possible predictors of disease activity of childhood glomerulonephritis.
Tomomi Aizawa, Tadaatsu Imaizumi, Kazushi Tsuruga, Shojiro Watanabe, Hidemi Yoshida, Naonori Kumagai, Etsuro Ito, Hiroshi Tanaka
The Tohoku journal of experimental medicine 231 ( 4 ) 265 - 270 2013.4
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Interaction between interferon-stimulated gene 56 and melanoma differentiation-associated gene 5 in Toll-like receptor 3 signaling in normal human mesangial cells.
Tadaatsu Imaizumi, Tomomi Aizawa-Yashiro, Tomoh Matsumiya, Hidemi Yoshida, Shojiro Watanabe, Kazushi Tsuruga, Tetsuya Tatsuta, Fei Xing, Ryo Hayakari, Pengfei Meng, Hiroshi Tanaka
American journal of nephrology 37 ( 2 ) 118 - 125 2013.2
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Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.
Pengfei Meng, Hidemi Yoshida, Tomoh Matsumiya, Tadaatsu Imaizumi, Kunikazu Tanji, Fei Xing, Ryo Hayakari, Junichi Dempoya, Tetsuya Tatsuta, Tomomi Aizawa-Yashiro, Junsei Mimura, Kunio Kosaka, Ken Itoh, Kei Satoh
Neuroscience research 75 ( 2 ) 94 - 102 2013.2
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Glomerular expression of fractalkine is induced by polyinosinic-polycytidylic acid in human mesangial cells: possible involvement of fractalkine after viral infection.
Tomomi Aizawa-Yashiro, Tadaatsu Imaizumi, Kazushi Tsuruga, Shojiro Watanabe, Tomoh Matsumiya, Ryo Hayakari, Hidemi Yoshida, Kei Satoh, Etsuro Ito, Hiroshi Tanaka
Pediatric research 73 ( 2 ) 180 - 186 2013.2
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Effects of Brazilian green propolis on double-stranded RNA-mediated induction of interferon-inducible gene and inhibition of recruitment of polymorphonuclear cells.
Ryo Hayakari, Tomoh Matsumiya, Fei Xing, Janeth C Tayone, Junichi Dempoya, Tetsuya Tatsuta, Tomomi Aizawa-Yashiro, Tadaatsu Imaizumi, Hidemi Yoshida, Kei Satoh
Journal of the science of food and agriculture 93 ( 3 ) 646 - 651 2013.2
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Inflammatory chemokine expression via Toll-like receptor 3 signaling in normal human mesangial cells.
Hiroshi Tanaka, Tadaatsu Imaizumi
Clinical & developmental immunology 2013 984708 - 984708 2013.2
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Treatment of young patients with lupus nephritis using calcineurin inhibitors.
Hiroshi Tanaka, Kazushi Tsuruga, Tomomi Aizawa-Yashiro, Shojiro Watanabe, Tadaatsu Imaizumi
World journal of nephrology 1 ( 6 ) 177 - 183 2012.12
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Double-stranded RNA induces biphasic STAT1 phosphorylation by both type I interferon (IFN)-dependent and type I IFN-independent pathways.
Junichi Dempoya, Tomoh Matsumiya, Tadaatsu Imaizumi, Ryo Hayakari, Fei Xing, Hidemi Yoshida, Ken Okumura, Kei Satoh
Journal of virology 86 ( 23 ) 12760 - 12769 2012.12
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Foreign RNA induces the degradation of mitochondrial antiviral signaling protein (MAVS): the role of intracellular antiviral factors.
Fei Xing, Tomoh Matsumiya, Koji Onomoto, Ryo Hayakari, Tadaatsu Imaizumi, Hidemi Yoshida, Mitsutoshi Yoneyama, Takashi Fujita, Kei Satoh
PloS one 7 ( 9 ) e45136 - e45136 2012.9
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Expression of melanoma differentiation associated gene 5 is increased in human gastric mucosa infected with Helicobacter pylori.
Tetsuya Tatsuta, Tadaatsu Imaizumi, Tadashi Shimoyama, Manabu Sawaya, Tanji Kunikazu, Tomoh Matsumiya, Hidemi Yoshida, Kei Satoh, Shinsaku Fukuda
Journal of clinical pathology 65 ( 9 ) 839 - 843 2012.9
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Melanoma differentiation-associated gene 5 regulates the expression of a chemokine CXCL10 in human mesangial cells: implications for chronic inflammatory renal diseases.
Tadaatsu Imaizumi, Tomomi Aizawa-Yashiro, Kazushi Tsuruga, Hiroshi Tanaka, Tomoh Matsumiya, Hidemi Yoshida, Tetsuya Tatsuta, Fei Xing, Ryo Hayakari, Kei Satoh
The Tohoku journal of experimental medicine 228 ( 1 ) 17 - 26 2012.8
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Characterization of retinoic acid-inducible gene-I (RIG-I) expression corresponding to viral infection and UVB in human keratinocytes
Kimura K, Matsuzaki Y, Nishikawa Y, Kitamura H, Akasaka E, Rokunohe D, Nakano H, Imaizumi T, Satoh K, Sawamura D.:
Journal of Dermatological Science 66 ( 1 ) 66 - 70 2012.1
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Imbalance towards Th1 pathway predominance in purpura neohritis with proteinuria.
Tsuruga K, Watanabe S, Oki E, Aizawa-Yashiro T, Yoshida H, Imaizumi T, Ito E, Tanaka H:
Pediatric Nephrology 26 2253 - 2258 2011.12
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Polyinosinic-polycytidylic acid induces the expression of interferon-stimulated gene 20 in mesangial cells
Imaizumi T, Tanaka H, et al
Nephron Experimental Nephrology 119 ( 2 ) e40 - e48 2011.8
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Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells.
Okabayashi T, Kojima T, Masaki T, Yokota S, Imaizumi T, et al
Virus Research 160 ( 1-2 ) 360 - 366 2011.7
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PERIOD1(PWE1) has anti-apoptptic effects, and PER3 has pro-apoptotic effects during ciaplatin (CDDP) treatment in human gingival cancer CA9-22 cells.
Sato F, Wu Y, Bhawal UK, Liu Y, Imaizumi T, et al
European journal of Cancer 47 ( 11 ) 1747 - 1758 2011.7
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Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation
Yoshida H, Mumura J, Imaizumi T, et al.
Neuroscience Research 69 291 - 298 2011.4
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Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation.
Yoshida H, Metoki N, Ishikawa A, Imaizumi T, Matsumiya T, Tanji K, Ota K, Ohyama C, Satoh K
Neuroscience Research 66 ( 3 ) 284 - 289 2010.3
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Interferon-α2b induces p21cip1/waf1 degradation and cell proliferation in HeLa cells.
Ota K, Matsumiya T, Sakuraba H, Imaizumi T, Yoshida H, Kawaguchi S, Fukuda S, Satoh K
Cell Cycle 9 ( 1 ) 131 - 139 2010.1
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PERIOD1 (PER1) is an anti-apoptotic factor in human pancreatic and hepatic cancer cells
Sato F, Nagata C, Liu Y, Suzuki T, Kondo J, Morohashi S, Imaizumi T, Kato Y, Kijima H:
Journal of Biochemistry 146 ( 6 ) 833 - 838 2009.12
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The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection.
Papon L, Oteiza A, Imaizumi T, Kato H, Brocchi E, Lawson TG, Akira S, Mechti N.
Virology 393 ( 2 ) 311 - 318 2009.10
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Metformin restores impaired HDL-mediated cholesterol efflux due to glycation.
Matsuki K, Tamasawa N, Yamashita M, Tanabe J, Murakami H, Imaiuzmi T, Satoh K, Suda T
Atherosclerosis 206 ( 2 ) 434 - 438 2009.10
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Retinoic acid-inducible gene-I is constitutively expressed and involved in IFN-gamma-stimulated CXCL9-11 production in intestinal epithelial cells
Kawaguchi S, Ishiguro Y, Imaizumi T, et al.
Immunology Letters 123 ( 1 ) 9 - 13 2009.3
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The levels of retinoic acid-incuble gene-I are regulated by heat shock protein 90-alpha.
Matsumiya T, Imaizumi T, et al.
Journal of Immunology 182 ( 5 ) 2717 - 2725 2009.3
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Tumor-necrosis factor-alpha induces retinoic acid-inducible gene-I in rheumatoid fibroblast-like synoviocytes
Imaizumi T. et al.
Immunology letters 122 ( 1 ) 89 - 93 2009.1
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Involvement of retinoic acid-inducible gene-I (RIG-I) in inflammation of rheumatoid fibroblast-like synoviocytes.(共著)
Imaizumi T., et al.
Clinical and Experimental Immunology 153 ( 7 ) 240 - 244 2008.7
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Retinoic aci-inducible gene-I is induced by interferon-gamma and regulates CXCL11 expression in HeLa cells
Yuzawa E, Imaizumi T, et al.
Life Sciences 82 ( 1 ) 672 - 675 2008.3
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Expression of mRNA for functional molecules in urinary sediment in glomerulonephritis
Tsugawa K, Suzuki K, Oki E, Imaizumi T, et al.
Pediatric Nephrology 23 ( 3 ) 395 - 401 2008.3
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Basic-helix-loop (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression
Sato F, Bhawal U, Kawamoto T, Fujimoto K, Imaizumi T, et al.
Genes to Cells 13 ( 2 ) 131 - 144 2008.2
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Negative feedback regulation of RIG-I-mediated anti-viral signaling by interferon-induced ISG15 conjugation
Kim MJ, Hwang SY, Imaizumi T, et al.
Journal of Virology 82 ( 3 ) 1474 - 1483 2008.2
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Expression of interferon-stimulated gene 20 (ISG20) in vascular endothelial cells
Imaizumi T, Mechti N, et al.
Microbiology and Immunology 52 ( 1 ) 30 - 35 2008.1
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Double-stranded RNA induces galectin-9 in vascular endothelial cells: involvement of TLR3, PI3K and IRF3 pathway.
Imaizumi T. et al.
Glycobiology 17 ( 7 ) 12C - 15C 2007.7