日本分子生物学会

Individual health-disease phase diagrams for disease prevention based on machine learning

Kazuki Nakamura, Eiichiro Uchino, Noriaki Sato, Ayano Araki, Kei Terayama, Ryosuke Kojima, Koichi Murashita, Ken Itoh, Tatsuya Mikami, Yoshinori Tamada, Yasushi Okuno

Journal of Biomedical Informatics   144   104448 - 104448   2023.8

Role of Nrf2 in 1,2-dichloropropane-induced cell proliferation and DNA damage in the mouse liver.

Kimura Y, Ekuban FA, Zong C, Sugie S, Zhang X, Itoh K, Yamamoto M, Ichihara S, Ohsako S, Ichihara G

Toxicological sciences : an official journal of the Society of Toxicology   195 ( 1 )   28 - 41   2023.6

Annual stability of the plasma Aß40/42 ratio and associated factors.

Nakamura T, Kawarabayashi T, Nakahata N, Itoh K, Ihara K, Nakaji S, Ikeda Y, Takatama M, Shoji M

Annals of clinical and translational neurology   10 ( 6 )   879 - 891   2023.6

Definition of a Dietary Pattern Expressing the Intake of Vegetables and Fruits and ItsAssociation with Intestinal Microbiota.

Yamauchi T, Koyama N, Hirai A, Suganuma H, Suzuki S, Murashita K, Mikami T, Tamada Y, Sato N, Imoto S, Itoh K, Nakaji S

15 ( 9 )   2104   2023.4

Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment.

Tatara Y, Yamazaki H, Katsuoka F, Chiba M, Saigusa D, Kasai S, Nakamura T, Inoue J, Aoki Y, Shoji M, Motoike IN, Tamada Y, Hashizume K, Shoji M, Kinoshita K, Murashita K, Nakaji S, Yamamoto M, Itoh K.

Curr Res Transl Med   71 ( 1 )   103367   2023.3

Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional Study

Nobuo Fuke, Takahiro Yamashita, Sunao Shimizu, Mai Matsumoto, Kaori Sawada, Songee Jung, Itoyo Tokuda, Mina Misawa, Shigenori Suzuki, Yusuke Ushida, Tatsuya Mikami, Ken Itoh, Hiroyuki Suganuma

Metabolites   13 ( 2 )   250 - 250   2023.2

Association between Advanced Glycation End-Products, Carotenoids, and Severe Erectile Dysfunction.

Fujita N, Ishida M, Iwane T, Suganuma H, Matsumoto M, Hatakeyama S, Yoneyama T, Hashimoto Y, Mikami T, Itoh K, Ohyama C

The world journal of men's health   13 ( 2 )   250 - 711   2023.1

Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation.

Atsushi Inose-Maruyama, Shuya Kasai, Ken Itoh

Methods in molecular biology (Clifton, N.J.)   2651   157 - 166   2023

Novel dicarbonyl metabolic pathway via mitochondrial ES1 possessing glyoxalase III activity.

Ito G, Tatara Y, Itoh K, Yamada M, Yamashita T, Sakamoto K, Nozaki T, Ishida K, Wake Y, Kaneko T, Fukuda T, Sugano E, Tomita H, Ozaki T

BBA advances   3   100092   2023

Protective role of Nrf2 in zinc oxide nanoparticles-induced lung inflammation in female mice and sexual dimorphism in susceptibility

Radwa Sehsah, Wenting Wu, Sahoko Ichihara, Naozumi Hashimoto, Cai Zong, Kyoka Yamazaki, Harue Sato, Ken Itoh, Masayuki Yamamoto, Ahmed Ali Elsayed, Soheir El-Bestar, Emily Kamel, Gaku Ichihara

Toxicology Letters   370   24 - 34   2022.11

Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment

Yota Tatara, Hiromi Yamazaki, Fumiki Katsuoka, Mitsuru Chiba, Daisuke Saigusa, Shuya Kasai, Tomohiro Nakamura, Jin Inoue, Yuichi Aoki, Miho Shoji, Ikuko Motoike, Yoshinori Tamada, Katsuhito Hashizume, Mikio Shoji, Kengo Kinoshita, Koichi Murashita, Shigeyuki Nakaji, Masayuki Yamamoto, Ken Itoh

Current Research in Translational Medicine   71 ( 1 )   103367 - 103367   2022.10

Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice

Sunao Shimizu, Shuya Kasai, Hiromi Yamazaki, Yota TATARA, Junsei Mimura, Máté János Engler, Kunikazu Tanji, Yoshikazu Nikaido, Takuro Inoue, Hiroyuki Suganuma, Koichi Wakabayashi, Ken Itoh

International Journal of Molecular Sciences   23 ( 15 )   2022.7

Machine learning diagnosis by immunoglobulin N-glycan signatures for precision diagnosis of urological diseases.

113 ( 7 )   2434 - 2445   2022.7

Impact of salivary and pancreatic amylase gene copy numbers on diabetes, obesity, and functional profiles of microbiome in Northern Japanese population.

Takanori Hasegawa, Masanori Kakuta, Rui Yamaguchi, Noriaki Sato, Tatsuya Mikami, Koichi Murashita, Shigeyuki Nakaji, Ken Itoh, Seiya Imoto

Scientific reports   12 ( 1 )   7628 - 7628   2022.5

Inducible Systemic <i>Gcn1</i> Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage

Jun Liu, Shuya Kasai, Yota Tatara, Hiromi Yamazaki, Junsei Mimura, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Sato Tsubasa, Taku Ozaki, Kunikazu Tanji, Koichi Wakabayashi, Hayato Maeda, Hiroki Mizukami, Yasuhiro Shinkai, Yoshito Kumagai, Hirofumi Tomita, Ken Itoh

International Journal of Molecular Sciences   23 ( 6 )   2022.3

Association of mitochondrial DNA haplogroup and hearing impairment with aging in Japanese general population of the Iwaki Health Promotion Project.

Shiori Miura, Akira Sasaki, Shuya Kasai, Takayuki Sugawara, Yasunori Maeda, Shinichi Goto, Takashi Kasai, Nami Shimizume, Songee Jung, Takuro Iwane, Ken Itoh, Atsushi Matsubara

Journal of human genetics   67 ( 6 )   369 - 375   2022.1

Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study

Kyi Mar Wai, Sawada Kaori, Ken Itoh, Okuyama Shinya, Yuka Uchikawa, Sakura Hayashi, Akiko Shiraki, Koichi Murashita, Shigeyuki Nakaji, Kazushige Ihara

Journal of Personalized Medicine   11 ( 12 )   2021.12

Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction.

Anqi Zhang, Takafumi Suzuki, Saki Adachi, Eriko Naganuma, Norio Suzuki, Tomonori Hosoya, Ken Itoh, Michael B Sporn, Masayuki Yamamoto

Molecular and cellular biology   41 ( 11 )   e0023621   2021.10

Age-Related Cognitive Decline and Prevalence of Mild Cognitive Impairment in the Iwaki Health Promotion Project.

Naoko Nakahata, Takumi Nakamura, Takeshi Kawarabayashi, Yusuke Seino, Sadanobu Ichii, Yoshio Ikeda, Masakuni Amari, Masamitsu Takatama, Koichi Murashita, Kazunari Ihara, Ken Itoh, Shigeyuki Nakaji, Mikio Shoji

Journal of Alzheimer's disease : JAD   84 ( 3 )   1233 - 1245   2021.10

多層オミックスと機械学習による軽度認知障害の予測モデルの構築

多田羅 洋太, 中村 智洋, 千葉 満, 三枝 大輔, 山嵜 博未, 勝岡 史城, 葛西 秋宅, 川瀬 倫子, 本間 リナ, 松田 りら, 藤本 哲太, 荘司 美穂, 元池 育子, 玉田 嘉紀, 橋爪 克仁, 東海林 幹夫, 木下 賢吾, 伊東 健

Dementia Japan   35 ( 4 )   660 - 660   2021.10

Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis.

Mayu Sugawara, Takumi Abe, Shuya Kasai, Ken Itoh, Taku Ozaki

Biochemistry and biophysics reports   27   101101 - 101101   2021.9

Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice.

Frederick Adams Ekuban, Cai Zong, Madoka Takikawa, Kota Morikawa, Toshihiro Sakurai, Sahoko Ichihara, Ken Itoh, Masayuki Yamamoto, Seiichiroh Ohsako, Gaku Ichihara

Toxicology   456   152785 - 152785   2021.5

Health improvement framework for actionable treatment planning using a surrogate Bayesian model

Nakamura Kazuki, Kojima Ryosuke, Uchino Eiichiro, Ono Koh, Yanagita Motoko, Murashita Koichi, Itoh Ken, Nakaji Shigeyuki, Okuno Yasushi

Nature Communications   12 ( 1 )   3088 - 3088   2021.5

Capillary Electrophoresis Mass Spectrometry-Based Metabolomics of Plasma Samples from Healthy Subjects in a Cross-Sectional Japanese Population Study.

Hiroyuki Yamamoto, Makoto Suzuki, Rira Matsuta, Kazunori Sasaki, Moon-Il Kang, Kenjiro Kami, Yota Tatara, Ken Itoh, Shigeyuki Nakaji

Metabolites   11 ( 5 )   314 - 314   2021.5

Characterization of mitochondrial calpain-5

Yusaku Chukai, Takeshi Iwamoto, Ken Itoh, Hiroshi Tomita, Taku Ozaki

Biochimica et Biophysica Acta - Molecular Cell Research   1868 ( 5 )   118989 - 118989   2021.4

Association between Serum Concentration of Carotenoid and Visceral Fat.

Mai Matsumoto, Hiroyuki Suganuma, Naoki Ozato, Sunao Shimizu, Mitsuhiro Katashima, Yoshihisa Katsuragi, Tatsuya Mikami, Ken Itoh, Shigeyuki Nakaji

Nutrients   13 ( 3 )   912   2021.3

The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress

Marie-France Dorion, Mukandila Mulumba, Shuya Kasai, Ken Itoh, William D. Lubell, Huy Ong

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY   2021   6691402 - 6691402   2021.3

Pulmonary effects of Fe3O4-PEG-PLGA nanoparticles in wild type and Nrf2 knockout mice following pharyngeal aspiration

SATO Harue, ZONG Cai, DEVINEAU Stéphanie, MCCORD Claire, ICHIHARA Sahoko, BROOKES Oliver, EKUBAN Frederick Adams, ITOH Ken, YAMAMOTO Masayuki, BOLAND Sonja, BAEZA-SQUIBAN Armelle, ICHIHARA Gaku

Annual Meeting of the Japanese Society of Toxicology   48.1 ( 0 )   P-32S   2021

JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis.

Máté János Engler, Junsei Mimura, Shun Yamazaki, Ken Itoh

FEBS open bio   10 ( 12 )   2771 - 2779   2020.12

特集 慢性腎臓病・透析患者の酸化ストレス-最新知見と治療展開 2.慢性腎臓病における酸化ストレス進展機序(1) 慢性腎臓病におけるNrf2-Keap1 経路の役割-CKD 治療薬としての期待

伊東 健, Liu Jun, 葛西 秋宅

臨床透析   36 ( 12 )   1521 - 1527   2020.11

Prevalence of the mitochondrial 1555 A>G and 1494 C>T mutations in a community-dwelling population in Japan

Yasunori Maeda, Akira Sasaki, Shuya Kasai, Shinichi Goto, Shin-ya Nishio, Kaori Sawada, Itoyo Tokuda, Ken Itoh, Shin-ichi Usami, Atsushi Matsubara

HUMAN GENOME VARIATION   7 ( 1 )   27 - 27   2020.9

Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging.

Sunao Shimizu, Junsei Mimura, Takanori Hasegawa, Eigo Shimizu, Seiya Imoto, Michiko Tsushima, Shuya Kasai, Hiromi Yamazaki, Yusuke Ushida, Hiroyuki Suganuma, Hirofumi Tomita, Masayuki Yamamoto, Shigeyuki Nakaji, Ken Itoh

PloS one   15 ( 8 )   e0236834 - e0236834   2020.8

Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness

Mai Matsumoto, Naoko Waki, Hiroyuki Suganuma, Ippei Takahashi, Sizuka Kurauchi, Kahori Sawada, Itoyo Tokuda, Mina Misawa, Masataka Ando, Ken Itoh, Kazushige Ihara, Shigeyuki Nakaji

Nutrients   12 ( 8 )   e2310 - e2310   2020.7

Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice.

Yoshikazu Yokono, Kenji Hanada, Masato Narita, Yota Tatara, Yousuke Kawamura, Naotake Miura, Kazutaka Kitayama, Masamichi Nakata, Masashi Nozaka, Tomo Kato, Natsumi Kudo, Michiko Tsushima, Yuichi Toyama, Ken Itoh, Hirofumi Tomita

Journal of the American Heart Association   9 ( 12 )   e015616 - e015616   2020.6

Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.

Hiromi Yamazaki, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Kunikazu Tanji, Koichi Wakabayashi, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Douglas R Cavener, Masayuki Yamamoto, Ken Itoh

PLoS genetics   16 ( 4 )   e1008693 - e1008693   2020.4

Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease

Michiko Tsushima, Jun Liu, Wataru Hirao, Hiromi Yamazaki, Hirofumi Tomita, Ken Itoh

Archives of Pharmacal Research   43 ( 3 )   286 - 296   2020.3

Deletion of Nrf2 enhances susceptibility to neurotoxic effects of acrylamide in mice

EKUBAN Frederick Adams, ZONG Cai, TAKIKAWA Madoka, MORIKAWA Kouta, SAKURAI Toshihiro, ICHIHARA Sahoko, ITOH Ken, YAMAMOTO Masayuki, OHSAKO Seiichiroh, ICHIHARA Gaku

Annual Meeting of the Japanese Society of Toxicology   47.1 ( 0 )   P-28E   2020

Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles

Radwa Sehsah, Wenting Wu, Sahoko Ichihara, Naozumi Hashimoto, Yoshinori Hasegawa, Cai Zong, Ken Itoh, Masayuki Yamamoto, Ahmed Ali Elsayed, Soheir El-Bestar, Emily Kamel, Gaku Ichihara

Particle and Fibre Toxicology   16 ( 1 )   47 - 47   2019.12

定量的プロテオミクス解析による急性期放射線骨髄障害の重症化リスク因子の探索

多田羅 洋太, 門前 暁, 伊東 健

日本生化学会大会プログラム・講演要旨集   92回   [3P - 307]   2019.9

Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes.

Junsei Mimura, Atsushi Inose-Maruyama, Shusuke Taniuchi, Kunio Kosaka, Hidemi Yoshida, Hiromi Yamazaki, Shuya Kasai, Nobuhiko Harada, Randal J Kaufman, Seiichi Oyadomari, Ken Itoh

International journal of molecular sciences   20 ( 7 )   1706   2019.4

Increase of Tumor Infiltrating γδ T-cells in Pancreatic Ductal Adenocarcinoma Through Remodeling of the Extracellular Matrix by a Hyaluronan Synthesis Suppressor, 4-Methylumbelliferone.

Akiko Suto, Daisuke Kudo, Eri Yoshida, Hayato Nagase, Shinichiro Suto, Junsei Mimura, Ken Itoh, Kenichi Hakamada

Pancreas   48 ( 2 )   292 - 298   2019.2

Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control

Kasai Shuya, Yamazaki Hiromi, Tanji Kunikazu, Engler Máté János, Matsumiya Tomoh, Itoh Ken

Journal of Clinical Biochemistry and Nutrition   64 ( 1 )   1 - 12   2019.1

Aging and APOE-e4 are determinative factors of plasma Ab42 levels.

Takumi Nakamura, Takeshi Kawarabayashi, Yusuke Seino, Mie Hirohata, Naoko Nakahata, Sakiko Narita, Ken Itoh, Shigeyuki Nakaji, Mikio Shoji

Annals of clinical and translational neurology   5 ( 10 )   1184 - 1191   2018.10

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.

Sharadha Dayalan Naidu, Aki Muramatsu, Ryota Saito, Soichiro Asami, Tadashi Honda, Tomonori Hosoya, Ken Itoh, Masayuki Yamamoto, Takafumi Suzuki, Albena T Dinkova-Kostova

Scientific reports   8 ( 1 )   8037 - 8037   2018.5

Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease.

Shuya Kasai, Junsei Mimura, Taku Ozaki, Ken Itoh

Frontiers in veterinary science   5   242 - 242   2018

Novel roles of glycosaminoglycans in the degradation of type I collagen by cathepsin K.

Yota Tatara, Shinichiro Suto, Ken Itoh

Glycobiology   27 ( 12 )   1089 - 1098   2017.12

Increase in proapoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2.

Shuya Kasai, Mary J E Richardson, Satoru Torii, Ken-Ichi Yasumoto, Hiroki Shima, Kazuhiko Igarashi, Ken Itoh, Kazuhiro Sogawa, Kazutaka Murayama

The FEBS journal   284 ( 23 )   4115 - 4127   2017.12

Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis.

Eiko Sakai, Masanobu Morita, Masahiro Ohuchi, Mizuho A Kido, Yutaka Fukuma, Kazuhisa Nishishita, Kuniaki Okamoto, Ken Itoh, Masayuki Yamamoto, Takayuki Tsukuba

FASEB journal : official publication of the Federation of American Societies for Experimental Biology   31 ( 9 )   4011 - 4022   2017.9

The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs.

Pei Y Liu, Nicholas Sokolowski, Su T Guo, Faraz Siddiqi, Bernard Atmadibrata, Thomas J Telfer, Yuting Sun, Lihong Zhang, Denise Yu, Joshua Mccarroll, Bing Liu, Rui H Yang, Xiang Y Guo, Andrew E Tee, Ken Itoh, Jenny Wang, Maria Kavallaris, Michelle Haber, Murray D Norris, Belamy B Cheung, Jennifer A Byrne, David S Ziegler, Glenn M Marshall, Marcel E Dinger, Rachel Codd, Xu D Zhang, Tao Liu

Oncotarget   7 ( 48 )   79217 - 79232   2016.11

The role of NUB1 in α-synuclein degradation in Lewy body disease model mice.

Kunikazu Tanji, Yasuo Miki, Atsushi Maruyama, Fumiaki Mori, Junsei Mimura, Ken Itoh, Tetsu Kamitani, Koichi Wakabayashi

Biochemical and biophysical research communications   470 ( 3 )   635 - 642   2016.2

Role of Nrf2 in the pathogenesis of atherosclerosis.

Junsei Mimura, Ken Itoh

Free radical biology & medicine   88 ( Pt B )   221 - 232   2015.11

Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.

Kunikazu Tanji, Yasuo Miki, Atsushi Maruyama, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Koichi Wakabayashi

Biochemical and biophysical research communications   465 ( 4 )   746 - 752   2015.10

p62 Deficiency Enhances α-Synuclein Pathology in Mice.

Kunikazu Tanji, Saori Odagiri, Yasuo Miki, Atsushi Maruyama, Yoshikazu Nikaido, Junsei Mimura, Fumiaki Mori, Eiji Warabi, Toru Yanagawa, Shinya Ueno, Ken Itoh, Koichi Wakabayashi

Brain pathology (Zurich, Switzerland)   25 ( 5 )   552 - 564   2015.9

Correction for Ye et al., Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition.

Peng Ye, Junsei Mimura, Tomomi Okada, Hideyo Sato, Tao Liu, Atsushi Maruyama, Chikara Ohyama, Ken Itoh

Molecular and cellular biology   35 ( 13 )   2366 - 2366   2015.7

Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells.

Pengfei Meng, Hidemi Yoshida, Kunikazu Tanji, Tomoh Matsumiya, Fei Xing, Ryo Hayakari, Liang Wang, Kazushi Tsuruga, Hiroshi Tanaka, Junsei Mimura, Kunio Kosaka, Ken Itoh, Ippei Takahashi, Shogo Kawaguchi, Tadaatsu Imaizumi

Neuroscience research   94   1 - 9   2015.5

Role of the Keap1/Nrf2 pathway in neurodegenerative diseases.

Hiromi Yamazaki, Kunikazu Tanji, Koichi Wakabayashi, Shin Matsuura, Ken Itoh

Pathology international   65 ( 5 )   210 - 219   2015.5

Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer.

Momoko Kimura, Tae Yamamoto, Jianyong Zhang, Ken Itoh, Motoki Kyo, Terue Kamiya, Hiroyuki Aburatani, Fumiki Katsuoka, Hirofumi Kurokawa, Toshiyuki Tanaka, Hozumi Motohashi, Masayuki Yamamoto

The Journal of biological chemistry   290 ( 17 )   10644 - 10644   2015.4

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria.

Ken Itoh, Peng Ye, Tomoh Matsumiya, Kunikazu Tanji, Taku Ozaki

Journal of clinical biochemistry and nutrition   56 ( 2 )   91 - 97   2015.3

Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding.

Atsushi Maruyama, Junsei Mimura, Ken Itoh

Nucleic acids research   42 ( 22 )   13599 - 13614   2014.12

Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition.

Peng Ye, Junsei Mimura, Tomomi Okada, Hideyo Sato, Tao Liu, Atsushi Maruyama, Chikara Ohyama, Ken Itoh

Molecular and cellular biology   34 ( 18 )   3421 - 3434   2014.9

Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.

Kunikazu Tanji, Yasuo Miki, Taku Ozaki, Atsushi Maruyama, Hidemi Yoshida, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Acta neuropathologica communications   2   50 - 50   2014.5

Carbocisteine reduces virus-induced pulmonary inflammation in mice exposed to cigarette smoke.

Yuichi Yageta, Yukio Ishii, Yuko Morishima, Satoshi Ano, Shigeo Ohtsuka, Masashi Matsuyama, Kaoru Takeuchi, Ken Itoh, Masayuki Yamamoto, Nobuyuki Hizawa

American journal of respiratory cell and molecular biology   50 ( 5 )   963 - 973   2014.5

Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.

Pengfei Meng et al.

Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.   75 ( 2 )   94 - 102   2013.2

Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases.

Kunikazu Tanji et al.

J Neuropathol Exp Neurol   75 ( 2 )   94 - 102   2013.1

Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation.

Nobuhiko Harada et al

Free Radic Biol Med   53 ( 12 )   2256 - 2262   2012.10

Methylation of the KEAP1 gene promoter region in human colorectal cancer

Hanada N. et al.

BMC cancer   12 ( 66 )   2012.2

Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers

Yamadori T. et al.

Oncogene   2012.1

Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes.

Mimura J. et al.

Journal of Biochemistry   150 ( 2 )   209 - 217   2011.8

The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response

Maruyama A. et al.

Biochemical Journal   436 ( 2 )   387 - 397   2011.6

Role of Nrf2 in host defense against influenza virus in cigarette smoke-exposed mice

Yageta Y. et al.

Journal of Virology   4679 ( 4690 )   2011.5

Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducers

Hirotsu Y. et al.

Genes to Cells   16 ( 4 )   406 - 415   2011.4

Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages

Harada N. et al.

Archive of Biochemistry and Biophysics   508 ( 1 )   101 - 109   2011.4

Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation

Yoshida H. et al.

Neuroscience Research   69 ( 4 )   291 - 298   2011.4

Discovery of the negative regulator of Nrf2, Keap1: a historical overview

Itoh K.et al.

Antioxidant redox signaling   13 ( 11 )   2010.12

Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene

Becks L. et al.

BMC cancer   10   540   2010.10

Relationship between radiosensitivity and Nrf2 target gene expression in human hematopoietic stem cells.

Kato K

Radiation Research   174 ( 2 )   177 - 184   2010.8

Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response

Ichihara S. et al.

Atherosclerosis Thrombosis Vascular Biology   30 ( 8 )   2010.8

Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity

Liu F. et al

Toxicological science   115 ( 2 )   2010.6

Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance

Kikuchi N.et al.

Respiration Research   11 ( 31 )   2010.5

Suppression of AhR signaling pathway is associated with the down-regulation of UDP-glucuronosyltransferases during BBN-induced urinary bladder carcinogenesis in mice（共著）

Iida K他

Journal of Biochemistry   147 ( 3 )   353 - 360   2010.3

Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells（共著）

Kosaka K他

Journal of Biochemistry   147 ( 1 )   73 - 81   2010.1

Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 1（共著）

Takagaki T他

The journal of Pharmacology and Experimental Therapeutics   331 ( 1 )   255 - 264   2009.10

Essential role of Nrf2 in keratinocyte protection from UVA by quercetin（共著）

Kimura S他

Biochemical Biophysical Research Communications   387   109 - 114   2009.9

Heavy ion beam irradiation regulates the mRNA expression in megakaryocytopoiesis from human hematopoietic stem/progenitor cells（共著）

Monzen S他

Journal of Radiation Research   50 ( 5 )   477 - 486   2009.9

Transcription factor Nrf2 mediates an adaptilve response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents（共著）

Higgins LG他

Toxicology and applied pharmacology   237 ( 3 )   267 - 280   2009.6

Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer（共著）

Homma S他

Clinical cancer research   15 ( 10 )   3423 - 3432   2009.5

Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice（共著）

Prince M. et al.

Toxicological Letter   185 ( 3 )   180 - 186   2009.3

Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice（共著）

Satoh T et al.

Biochemical and Biophysical Research Communications   380 ( 2 )   298 - 302   2009.3

Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice (共著）

Yoh K. et al.

Genes to Cells   13 ( 11 )   1159 - 1170   2008.11

Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements（共著）

Maruyama A. et al.

Archive of Biochemistry and Biophysics   477 ( 1 )   139 - 145   2008.9

Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts（共著）

Harada H. et al.

Free Radical Research   2 ( 4 )   297 - 304   2008.7

Keap1 Regulates the Constitutive Expression of GST A1 during Differentiation of Caco-2 Cells（共著）

Kusano Y

Biochemistry   47 ( 23 )   6169 - 6177   2008.6

A Possible Role of Nrf2 in Prevention of Renal Oxidative Damage by Ferric Nitrilotriacetate（共著）

Kanki K. et al.

Toxicological Pathology   36 ( 2 )   353 - 361   2008.4

Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners（共著）

Satoh T et al.

Neuroscience letter   434 ( 3 )   260 - 265   2008.4

Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein

Higgins LG et al

Toxicology and applied pharmacology   226 ( 3 )   328 - 327   2008.2

Carnosic acid, a catechol-type electrophilic compound, protects neuron both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of target cysteines on Keap1

Satoh T et al.

Journal of neurochemistry   104 ( 4 )   1116 - 1131   2008.2

Attenuation of UVB-Induced Sunburn Reaction and Oxidative DNA Damage with no Alterations in UVB-Induced Skin Carcinogenesis in Nrf2 Gene-Deficient Mice（共著）

Kawachi Y. et al.

Journal of Investigative Dermatology   128   1773 - 1779   2008.1

Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer

Kimura M et al.

Journal of biological chemistry   282 ( 46 )   33681 - 33690   2007.11

Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carconogenesis

Iida K et al

Carcinogenesis   28 ( 11 )   2398 - 2403   2007.11

Subcellular localization and cytoplasmic complex status of endogenous Keap1

Watai Y et al

Gene to Cells   12 ( 10 )   1163 - 1178   2007.10

Double-stranded RNA induces galectin-9 in vascular endothelial cells:involvement of TLR3, PI3K, and IRF3 pathway

Imaizumi T et al

Glycobiology   17 ( 7 )   12C - 15C   2007.7

Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes

Zhang J et al

Biochemical Journal   404 ( 3 )   459 - 466   2007.6

Enhanced spontaneous and benzo(a)pyrene-induced mutatins in the lungs of Nrf2-deficient gpt delta mice

Aoki Y et al

Cancer Res   67 ( 12 )   5643 - 5648   2007.6

Prevalence of the mitochondrial 1555 A > G and 1494 C > T mutations in a community-dwelling population in Japan (vol 7, 27, 2020)

Yasunori Maeda, Akira Sasaki, Shuya Kasai, Shinichi Goto, Shin-ya Nishio, Kaori Sawada, Itoyo Tokuda, Ken Itoh, Shin-ichi Usami, Atsushi Matsubara

HUMAN GENOME VARIATION   7 ( 1 )   36   2020.10

ストレス応答性転写因子Nrf2とATF4の相互作用を基盤にした疾患予防・アンチエイジング法の開発.

葛西秋宅、清水直、多田羅洋太、三村純正、伊東健.

BIO Clinica   35 ( 10 )   60 - 64   2020.8

ファイトケミカルによるKeap1-Nrf2経路の活性化.

三村純正、伊東健

実験医学増刊   38 ( 10 )   99 - 105   2020.6

Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease.

Tsushima M, Liu J, Hirao W, Yamazaki H, Tomita H, Itoh K.

Archives of pharmacal research   43 ( 3 )   286 - 296   2020.3

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura, Ken Itoh

BIOMOLECULES   10 ( 2 )   320 - 320   2020.2

Deficiency of P62/SQSTM1 Exacerbates Doxorubicin-Induced Cardiac Dysfunction

Michiko Tsushima, Junsei Mimura, Jun Liu, Hiromi Yamazaki, Shuya Kasai, Hirofumi Tomita, Ken Itoh

CIRCULATION   140   2019.11

Nrf2とATF4の相互作用に着目した疾患予防・アンチエイジング法の開発.

伊東健、平尾航、加藤恭丈、三村純正、葛西秋宅.

メディカルサイエンスダイジェスト   45 ( 4 )   56 - 59   2019.4

定量的プロテオミクス解析による急性期放射線骨髄障害の重症化リスク因子の探索

多田羅洋太, 門前暁, 伊東健

日本生化学会大会(Web)   92nd   2019

Cytoprotective response by Nrf2

Junsei Mimura, Ken Itoh

Clinical immunology and alergy   67 ( 6 )   642 - 648   2017.6

Role of Nrf2 in the pathogenesis of atherosclerosis.

Mimura J, Itoh K.

Free Radic Biol Med.   88   221 - 232   2015.11

Role of the Keap1/Nrf2 pathway in neurodegenerative diseases.

Yamazaki H, Tanji K, Wakabayashi K, Matsuura S, Itoh K.

Pathol Int.   65 ( 5 )   210 - 219   2015.5

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria.

Itoh K, Ye P, Matsumiya T, Tanji K, Ozaki T.

J Clin Biochem Nutr.   56 ( 2 )   91 - 97   2015.3

活性酸素種で活性化する転写経路のクロストーク―Nrf2/Keap1経路を中心に

丸山敦史、伊東健

実験医学   30 ( 17 )   2718 - 2725   2012.11

Intracellular Signaling Cascade for the Protection Against Oxidative Stress : Nrf2/Keap1 System

50 ( 6 )   423 - 429   2012.6

Disease regulation by Nrf2 antioxidant system

Itoh K

Biochemistry   81 ( 6 )   447 - 455   2009.6