Papers - ITOH KEN
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Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages.
Aoyama Y, Yamazaki H, Nishimura K, Nomura M, Shigehiro T, Suzuki T, Zang W, Tatara Y, Ito H, Hayashi Y, Koike Y, Fukumoto M, Tanaka A, Zhang Y, Saika W, Hasegawa C, Kasai S, Kong Y, Minakuchi Y, Itoh K, Yamamoto M, Toyokuni S, Toyoda A, Ikawa T, Takaori-Kondo A, Inoue D
145 ( 11 ) 1149 - 1163 2025.3
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Dairy consumption has a partial inverse association with systolic blood pressure and hypertension in populations with high salt and low dairy diets: cross-sectional data analysis from the Iwaki Health Promotion Project.
Kawata D, Ueno HM, Nakano A, Tatara Y, Tamada Y, Mikami T, Murashita K, Nakaji S, Itoh K
Hypertension research : official journal of the Japanese Society of Hypertension 48 1409 - 1421 2025.1
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Nrf2 induction potency of plant-derived compounds determined using an antioxidant response element luciferase reporter and conventional NAD(P)H-quinone acceptor oxidoreductase 1 activity assay.
Tamaru E, Kokubu D, Ushida Y, Itoh K
17 ( 1 ) 373 2024.12
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Association between NF-E2-related factor 2 polymorphism and age-related hearing loss in the general Japanese population from the Iwaki health promotion project.
Takashi Kasai, Akira Sasaki, Shuya Kasai, Shiori Miura, Shinichi Goto, Ryoko Yotsuyanagi, Tatsuya Mikami, Yoshinori Tamada, Ken Itoh, Atsushi Matsubara
Acta oto-laryngologica 145 ( 1 ) 1 - 7 2024.12
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Novel insight into nicotinamide adenine dinucleotide and related metabolites in cancer patients undergoing surgery.
Fujita H, Wakiya T, Tatara Y, Ishido K, Sakamoto Y, Kimura N, Morohashi H, Miura T, Muroya T, Akasaka H, Yokoyama H, Kanda T, Kubota S, Ichisawa A, Ogasawara K, Kuwata D, Takahashi Y, Nakamura A, Yamazaki K, Yamada T, Matsuyama R, Kanou M, Yamana K, Itoh K, Hakamada K
14 ( 1 ) 16557 2024.7
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Association between sex hormones and erectile dysfunction in men without hypoandrogenism.
Fujita N, Okamoto T, Yamamoto H, Yoneyama T, Hashimoto Y, Mikami T, Itoh K, Ohyama C, Hatakeyama S
Scientific reports 14 ( 1 ) 13433 2024.6
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Dairy consumption, bone turnover biomarkers, and osteo sono assessment index in Japanese adults: A cross-sectional analysis of data from the Iwaki Health Promotion Project.
Nakano A, Ueno HM, Kawata D, Tatara Y, Tamada Y, Mikami T, Murashita K, Nakaji S, Itoh K
Bone reports 21 101770 2024.6
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‹一般演題抄録›新型コロナウイルスワクチン接種に伴う抗体産生様態と副反応について
宮本 奈穂美, 玉田 嘉紀, 伊東 健, 齋藤 紀先, 山吉 誠也, 中路 重之, 三上 達也
弘前医学 74 ( 1-4 ) 142 2024.3
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Emerging Role of GCN1 in Disease and Homeostasis.
Tatara Y, Kasai S, Kokubu D, Tsujita T, Mimura J, Itoh K
International journal of molecular sciences 25 ( 5 ) 2998 2024.3
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Role of Nrf2-Mediated Oxidative Stress Response Pathway in the Regulation of Mibyou
ITOH Ken, KASAI Shuya, TATARA Yota
KAGAKU TO SEIBUTSU 62 ( 3 ) 145 - 153 2024.3
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Author Correction: C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.
Dayalan Naidu S, Muramatsu A, Saito R, Asami S, Honda T, Hosoya T, Itoh K, Yamamoto M, Suzuki T, Dinkova-Kostova AT
Scientific reports 14 ( 1 ) 4774 2024.2
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Role of calpain-5 in cerebral ischemia and reperfusion injury.
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki
Biochimica et biophysica acta. General subjects 1868 ( 1 ) 130506 - 130506 2024.1
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Mitochondrial Reactive Oxygen Species, Insulin Resistance, and Nrf2-Mediated Oxidative Stress Response—Toward an Actionable Strategy for Anti-Aging
Kasai S, Kokubu D, Mizukami H, Itoh K
Biomolecules 13 ( 10 ) 1544 2023.10
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Does the Protective Effect of Zinc on Telomere Length Depend on the Presence of Hypertension or Type 2 Diabetes? Results from the Iwaki Health Promotion Project, Japan.
Sato M, Wai KM, Itoh K, Yang Y, Uchikawa Y, Ito Y, Nakaji S, Ihara K
Nutrients 15 ( 20 ) 4373 - 4373 2023.10
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Individual health-disease phase diagrams for disease prevention based on machine learning
Kazuki Nakamura, Eiichiro Uchino, Noriaki Sato, Ayano Araki, Kei Terayama, Ryosuke Kojima, Koichi Murashita, Ken Itoh, Tatsuya Mikami, Yoshinori Tamada, Yasushi Okuno
Journal of Biomedical Informatics 144 104448 - 104448 2023.8
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Role of Nrf2 in 1,2-dichloropropane-induced cell proliferation and DNA damage in the mouse liver.
Kimura Y, Ekuban FA, Zong C, Sugie S, Zhang X, Itoh K, Yamamoto M, Ichihara S, Ohsako S, Ichihara G
Toxicological sciences : an official journal of the Society of Toxicology 195 ( 1 ) 28 - 41 2023.6
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Annual stability of the plasma Aß40/42 ratio and associated factors.
Nakamura T, Kawarabayashi T, Nakahata N, Itoh K, Ihara K, Nakaji S, Ikeda Y, Takatama M, Shoji M
Annals of clinical and translational neurology 10 ( 6 ) 879 - 891 2023.6
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Definition of a Dietary Pattern Expressing the Intake of Vegetables and Fruits and ItsAssociation with Intestinal Microbiota.
Yamauchi T, Koyama N, Hirai A, Suganuma H, Suzuki S, Murashita K, Mikami T, Tamada Y, Sato N, Imoto S, Itoh K, Nakaji S
Nutrients 15 ( 9 ) 2104 2023.4
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Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment.
Tatara Y, Yamazaki H, Katsuoka F, Chiba M, Saigusa D, Kasai S, Nakamura T, Inoue J, Aoki Y, Shoji M, Motoike IN, Tamada Y, Hashizume K, Shoji M, Kinoshita K, Murashita K, Nakaji S, Yamamoto M, Itoh K.
Curr Res Transl Med 71 ( 1 ) 103367 2023.3
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Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional Study
Nobuo Fuke, Takahiro Yamashita, Sunao Shimizu, Mai Matsumoto, Kaori Sawada, Songee Jung, Itoyo Tokuda, Mina Misawa, Shigenori Suzuki, Yusuke Ushida, Tatsuya Mikami, Ken Itoh, Hiroyuki Suganuma
Metabolites 13 ( 2 ) 250 - 250 2023.2
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Association between Advanced Glycation End-Products, Carotenoids, and Severe Erectile Dysfunction
Naoki Fujita, Mizuri Ishida, Takuro Iwane, Hiroyuki Suganuma, Mai Matsumoto, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Tatsuya Mikami, Ken Itoh, Chikara Ohyama
The World Journal of Men's Health 13 ( 2 ) 250 - 711 2023.1
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Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation.
Atsushi Inose-Maruyama, Shuya Kasai, Ken Itoh
Methods in molecular biology (Clifton, N.J.) 2651 157 - 166 2023
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Novel dicarbonyl metabolic pathway via mitochondrial ES1 possessing glyoxalase III activity
Ginga Ito, Yota Tatara, Ken Itoh, Miwa Yamada, Tetsuro Yamashita, Kimitoshi Sakamoto, Takayuki Nozaki, Kinji Ishida, Yui Wake, Takehito Kaneko, Tomokazu Fukuda, Eriko Sugano, Hiroshi Tomita, Taku Ozaki
BBA Advances 3 100092 - 100092 2023
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Protective role of Nrf2 in zinc oxide nanoparticles-induced lung inflammation in female mice and sexual dimorphism in susceptibility
Radwa Sehsah, Wenting Wu, Sahoko Ichihara, Naozumi Hashimoto, Cai Zong, Kyoka Yamazaki, Harue Sato, Ken Itoh, Masayuki Yamamoto, Ahmed Ali Elsayed, Soheir El-Bestar, Emily Kamel, Gaku Ichihara
Toxicology Letters 370 24 - 34 2022.11
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Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment
Yota Tatara, Hiromi Yamazaki, Fumiki Katsuoka, Mitsuru Chiba, Daisuke Saigusa, Shuya Kasai, Tomohiro Nakamura, Jin Inoue, Yuichi Aoki, Miho Shoji, Ikuko Motoike, Yoshinori Tamada, Katsuhito Hashizume, Mikio Shoji, Kengo Kinoshita, Koichi Murashita, Shigeyuki Nakaji, Masayuki Yamamoto, Ken Itoh
Current Research in Translational Medicine 71 ( 1 ) 103367 - 103367 2022.10
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Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice
Sunao Shimizu, Shuya Kasai, Hiromi Yamazaki, Yota TATARA, Junsei Mimura, Máté János Engler, Kunikazu Tanji, Yoshikazu Nikaido, Takuro Inoue, Hiroyuki Suganuma, Koichi Wakabayashi, Ken Itoh
International Journal of Molecular Sciences 23 ( 15 ) 2022.7
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Machine learning diagnosis by immunoglobulin N-glycan signatures for precision diagnosis of urological diseases.
Iwamura, H., Mizuno, K., Akamatsu, S., Hatakeyama, S., Tobisawa, Y., Narita, S., Narita, T., Yamashita, S., Kawamura, S., Sakurai, T., Fujita, N., Kodama, H., Noro, D., Kakizaki, I., Nakaji, S., Itoh, K., Tsuchiya, N., Ito, A., Habuchi, T., Ohyama, C., Yoneyama, T.
Cancer Science 113 ( 7 ) 2434 - 2445 2022.7
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Impact of salivary and pancreatic amylase gene copy numbers on diabetes, obesity, and functional profiles of microbiome in Northern Japanese population.
Takanori Hasegawa, Masanori Kakuta, Rui Yamaguchi, Noriaki Sato, Tatsuya Mikami, Koichi Murashita, Shigeyuki Nakaji, Ken Itoh, Seiya Imoto
Scientific reports 12 ( 1 ) 7628 - 7628 2022.5
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Inducible Systemic <i>Gcn1</i> Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage
Jun Liu, Shuya Kasai, Yota Tatara, Hiromi Yamazaki, Junsei Mimura, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Sato Tsubasa, Taku Ozaki, Kunikazu Tanji, Koichi Wakabayashi, Hayato Maeda, Hiroki Mizukami, Yasuhiro Shinkai, Yoshito Kumagai, Hirofumi Tomita, Ken Itoh
International Journal of Molecular Sciences 23 ( 6 ) 2022.3
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Association of mitochondrial DNA haplogroup and hearing impairment with aging in Japanese general population of the Iwaki Health Promotion Project.
Shiori Miura, Akira Sasaki, Shuya Kasai, Takayuki Sugawara, Yasunori Maeda, Shinichi Goto, Takashi Kasai, Nami Shimizume, Songee Jung, Takuro Iwane, Ken Itoh, Atsushi Matsubara
Journal of human genetics 67 ( 6 ) 369 - 375 2022.1
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Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study
Kyi Mar Wai, Sawada Kaori, Ken Itoh, Okuyama Shinya, Yuka Uchikawa, Sakura Hayashi, Akiko Shiraki, Koichi Murashita, Shigeyuki Nakaji, Kazushige Ihara
Journal of Personalized Medicine 11 ( 12 ) 2021.12
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Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction.
Anqi Zhang, Takafumi Suzuki, Saki Adachi, Eriko Naganuma, Norio Suzuki, Tomonori Hosoya, Ken Itoh, Michael B Sporn, Masayuki Yamamoto
Molecular and cellular biology 41 ( 11 ) e0023621 2021.10
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Age-Related Cognitive Decline and Prevalence of Mild Cognitive Impairment in the Iwaki Health Promotion Project.
Naoko Nakahata, Takumi Nakamura, Takeshi Kawarabayashi, Yusuke Seino, Sadanobu Ichii, Yoshio Ikeda, Masakuni Amari, Masamitsu Takatama, Koichi Murashita, Kazunari Ihara, Ken Itoh, Shigeyuki Nakaji, Mikio Shoji
Journal of Alzheimer's disease : JAD 84 ( 3 ) 1233 - 1245 2021.10
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多層オミックスと機械学習による軽度認知障害の予測モデルの構築
多田羅 洋太, 中村 智洋, 千葉 満, 三枝 大輔, 山嵜 博未, 勝岡 史城, 葛西 秋宅, 川瀬 倫子, 本間 リナ, 松田 りら, 藤本 哲太, 荘司 美穂, 元池 育子, 玉田 嘉紀, 橋爪 克仁, 東海林 幹夫, 木下 賢吾, 伊東 健
Dementia Japan 35 ( 4 ) 660 - 660 2021.10
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Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis.
Mayu Sugawara, Takumi Abe, Shuya Kasai, Ken Itoh, Taku Ozaki
Biochemistry and biophysics reports 27 101101 - 101101 2021.9
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Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice.
Frederick Adams Ekuban, Cai Zong, Madoka Takikawa, Kota Morikawa, Toshihiro Sakurai, Sahoko Ichihara, Ken Itoh, Masayuki Yamamoto, Seiichiroh Ohsako, Gaku Ichihara
Toxicology 456 152785 - 152785 2021.5
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Health improvement framework for actionable treatment planning using a surrogate Bayesian model
Nakamura Kazuki, Kojima Ryosuke, Uchino Eiichiro, Ono Koh, Yanagita Motoko, Murashita Koichi, Itoh Ken, Nakaji Shigeyuki, Okuno Yasushi
Nature Communications 12 ( 1 ) 3088 - 3088 2021.5
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Capillary Electrophoresis Mass Spectrometry-Based Metabolomics of Plasma Samples from Healthy Subjects in a Cross-Sectional Japanese Population Study.
Hiroyuki Yamamoto, Makoto Suzuki, Rira Matsuta, Kazunori Sasaki, Moon-Il Kang, Kenjiro Kami, Yota Tatara, Ken Itoh, Shigeyuki Nakaji
Metabolites 11 ( 5 ) 314 - 314 2021.5
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Characterization of mitochondrial calpain-5
Yusaku Chukai, Takeshi Iwamoto, Ken Itoh, Hiroshi Tomita, Taku Ozaki
Biochimica et Biophysica Acta - Molecular Cell Research 1868 ( 5 ) 118989 - 118989 2021.4
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Association between Serum Concentration of Carotenoid and Visceral Fat.
Mai Matsumoto, Hiroyuki Suganuma, Naoki Ozato, Sunao Shimizu, Mitsuhiro Katashima, Yoshihisa Katsuragi, Tatsuya Mikami, Ken Itoh, Shigeyuki Nakaji
Nutrients 13 ( 3 ) 912 2021.3
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The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress
Marie-France Dorion, Mukandila Mulumba, Shuya Kasai, Ken Itoh, William D. Lubell, Huy Ong
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2021 6691402 - 6691402 2021.3
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Pulmonary effects of Fe3O4-PEG-PLGA nanoparticles in wild type and Nrf2 knockout mice following pharyngeal aspiration
SATO Harue, ZONG Cai, DEVINEAU Stéphanie, MCCORD Claire, ICHIHARA Sahoko, BROOKES Oliver, EKUBAN Frederick Adams, ITOH Ken, YAMAMOTO Masayuki, BOLAND Sonja, BAEZA-SQUIBAN Armelle, ICHIHARA Gaku
Annual Meeting of the Japanese Society of Toxicology 48.1 ( 0 ) P-32S 2021
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JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis.
Máté János Engler, Junsei Mimura, Shun Yamazaki, Ken Itoh
FEBS open bio 10 ( 12 ) 2771 - 2779 2020.12
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特集 慢性腎臓病・透析患者の酸化ストレス-最新知見と治療展開 2.慢性腎臓病における酸化ストレス進展機序(1) 慢性腎臓病におけるNrf2-Keap1 経路の役割-CKD 治療薬としての期待
伊東 健, Liu Jun, 葛西 秋宅
臨床透析 36 ( 12 ) 1521 - 1527 2020.11
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Prevalence of the mitochondrial 1555 A>G and 1494 C>T mutations in a community-dwelling population in Japan
Yasunori Maeda, Akira Sasaki, Shuya Kasai, Shinichi Goto, Shin-ya Nishio, Kaori Sawada, Itoyo Tokuda, Ken Itoh, Shin-ichi Usami, Atsushi Matsubara
HUMAN GENOME VARIATION 7 ( 1 ) 27 - 27 2020.9
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Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging.
Sunao Shimizu, Junsei Mimura, Takanori Hasegawa, Eigo Shimizu, Seiya Imoto, Michiko Tsushima, Shuya Kasai, Hiromi Yamazaki, Yusuke Ushida, Hiroyuki Suganuma, Hirofumi Tomita, Masayuki Yamamoto, Shigeyuki Nakaji, Ken Itoh
PloS one 15 ( 8 ) e0236834 - e0236834 2020.8
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Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness
Mai Matsumoto, Naoko Waki, Hiroyuki Suganuma, Ippei Takahashi, Sizuka Kurauchi, Kahori Sawada, Itoyo Tokuda, Mina Misawa, Masataka Ando, Ken Itoh, Kazushige Ihara, Shigeyuki Nakaji
Nutrients 12 ( 8 ) e2310 - e2310 2020.7
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Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice.
Yoshikazu Yokono, Kenji Hanada, Masato Narita, Yota Tatara, Yousuke Kawamura, Naotake Miura, Kazutaka Kitayama, Masamichi Nakata, Masashi Nozaka, Tomo Kato, Natsumi Kudo, Michiko Tsushima, Yuichi Toyama, Ken Itoh, Hirofumi Tomita
Journal of the American Heart Association 9 ( 12 ) e015616 - e015616 2020.6
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Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.
Hiromi Yamazaki, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Kunikazu Tanji, Koichi Wakabayashi, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Douglas R Cavener, Masayuki Yamamoto, Ken Itoh
PLoS genetics 16 ( 4 ) e1008693 - e1008693 2020.4
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Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease
Michiko Tsushima, Jun Liu, Wataru Hirao, Hiromi Yamazaki, Hirofumi Tomita, Ken Itoh
Archives of Pharmacal Research 43 ( 3 ) 286 - 296 2020.3
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Deletion of Nrf2 enhances susceptibility to neurotoxic effects of acrylamide in mice
EKUBAN Frederick Adams, ZONG Cai, TAKIKAWA Madoka, MORIKAWA Kouta, SAKURAI Toshihiro, ICHIHARA Sahoko, ITOH Ken, YAMAMOTO Masayuki, OHSAKO Seiichiroh, ICHIHARA Gaku
Annual Meeting of the Japanese Society of Toxicology 47.1 ( 0 ) P-28E 2020
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Nrf2 in the Regulation of Endothelial Cell Homeostasis During Inflammation
Yamazaki, H., Itoh, K.
Progress in Inflammation Research 85 2020
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Health improvement framework for planning actionable treatment process using surrogate Bayesian model.
Kazuki Nakamura, Ryosuke Kojima, Eiichiro Uchino, Koichi Murashita, Ken Itoh, Shigeyuki Nakaji, Yasushi Okuno
CoRR abs/2010.16087 2020
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Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles
Radwa Sehsah, Wenting Wu, Sahoko Ichihara, Naozumi Hashimoto, Yoshinori Hasegawa, Cai Zong, Ken Itoh, Masayuki Yamamoto, Ahmed Ali Elsayed, Soheir El-Bestar, Emily Kamel, Gaku Ichihara
Particle and Fibre Toxicology 16 ( 1 ) 47 - 47 2019.12
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定量的プロテオミクス解析による急性期放射線骨髄障害の重症化リスク因子の探索
多田羅 洋太, 門前 暁, 伊東 健
日本生化学会大会プログラム・講演要旨集 92回 [3P - 307] 2019.9
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Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes.
Junsei Mimura, Atsushi Inose-Maruyama, Shusuke Taniuchi, Kunio Kosaka, Hidemi Yoshida, Hiromi Yamazaki, Shuya Kasai, Nobuhiko Harada, Randal J Kaufman, Seiichi Oyadomari, Ken Itoh
International journal of molecular sciences 20 ( 7 ) 1706 2019.4
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Increase of Tumor Infiltrating γδ T-cells in Pancreatic Ductal Adenocarcinoma Through Remodeling of the Extracellular Matrix by a Hyaluronan Synthesis Suppressor, 4-Methylumbelliferone.
Akiko Suto, Daisuke Kudo, Eri Yoshida, Hayato Nagase, Shinichiro Suto, Junsei Mimura, Ken Itoh, Kenichi Hakamada
Pancreas 48 ( 2 ) 292 - 298 2019.2
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Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control
Kasai Shuya, Yamazaki Hiromi, Tanji Kunikazu, Engler Máté János, Matsumiya Tomoh, Itoh Ken
Journal of Clinical Biochemistry and Nutrition 64 ( 1 ) 1 - 12 2019.1
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Aging and APOE-e4 are determinative factors of plasma Ab42 levels.
Takumi Nakamura, Takeshi Kawarabayashi, Yusuke Seino, Mie Hirohata, Naoko Nakahata, Sakiko Narita, Ken Itoh, Shigeyuki Nakaji, Mikio Shoji
Annals of clinical and translational neurology 5 ( 10 ) 1184 - 1191 2018.10
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C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.
Sharadha Dayalan Naidu, Aki Muramatsu, Ryota Saito, Soichiro Asami, Tadashi Honda, Tomonori Hosoya, Ken Itoh, Masayuki Yamamoto, Takafumi Suzuki, Albena T Dinkova-Kostova
Scientific reports 8 ( 1 ) 8037 - 8037 2018.5
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Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease.
Shuya Kasai, Junsei Mimura, Taku Ozaki, Ken Itoh
Frontiers in veterinary science 5 242 - 242 2018
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Novel roles of glycosaminoglycans in the degradation of type I collagen by cathepsin K.
Yota Tatara, Shinichiro Suto, Ken Itoh
Glycobiology 27 ( 12 ) 1089 - 1098 2017.12
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Increase in proapoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2.
Shuya Kasai, Mary J E Richardson, Satoru Torii, Ken-Ichi Yasumoto, Hiroki Shima, Kazuhiko Igarashi, Ken Itoh, Kazuhiro Sogawa, Kazutaka Murayama
The FEBS journal 284 ( 23 ) 4115 - 4127 2017.12
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Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis.
Eiko Sakai, Masanobu Morita, Masahiro Ohuchi, Mizuho A Kido, Yutaka Fukuma, Kazuhisa Nishishita, Kuniaki Okamoto, Ken Itoh, Masayuki Yamamoto, Takayuki Tsukuba
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31 ( 9 ) 4011 - 4022 2017.9
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The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs.
Pei Y Liu, Nicholas Sokolowski, Su T Guo, Faraz Siddiqi, Bernard Atmadibrata, Thomas J Telfer, Yuting Sun, Lihong Zhang, Denise Yu, Joshua Mccarroll, Bing Liu, Rui H Yang, Xiang Y Guo, Andrew E Tee, Ken Itoh, Jenny Wang, Maria Kavallaris, Michelle Haber, Murray D Norris, Belamy B Cheung, Jennifer A Byrne, David S Ziegler, Glenn M Marshall, Marcel E Dinger, Rachel Codd, Xu D Zhang, Tao Liu
Oncotarget 7 ( 48 ) 79217 - 79232 2016.11
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The role of NUB1 in α-synuclein degradation in Lewy body disease model mice.
Kunikazu Tanji, Yasuo Miki, Atsushi Maruyama, Fumiaki Mori, Junsei Mimura, Ken Itoh, Tetsu Kamitani, Koichi Wakabayashi
Biochemical and biophysical research communications 470 ( 3 ) 635 - 642 2016.2
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Role of Nrf2 in the pathogenesis of atherosclerosis.
Junsei Mimura, Ken Itoh
Free radical biology & medicine 88 ( Pt B ) 221 - 232 2015.11
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Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.
Kunikazu Tanji, Yasuo Miki, Atsushi Maruyama, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Koichi Wakabayashi
Biochemical and biophysical research communications 465 ( 4 ) 746 - 752 2015.10
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p62 Deficiency Enhances α-Synuclein Pathology in Mice.
Kunikazu Tanji, Saori Odagiri, Yasuo Miki, Atsushi Maruyama, Yoshikazu Nikaido, Junsei Mimura, Fumiaki Mori, Eiji Warabi, Toru Yanagawa, Shinya Ueno, Ken Itoh, Koichi Wakabayashi
Brain pathology (Zurich, Switzerland) 25 ( 5 ) 552 - 564 2015.9
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Correction for Ye et al., Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition.
Peng Ye, Junsei Mimura, Tomomi Okada, Hideyo Sato, Tao Liu, Atsushi Maruyama, Chikara Ohyama, Ken Itoh
Molecular and cellular biology 35 ( 13 ) 2366 - 2366 2015.7
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Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells.
Pengfei Meng, Hidemi Yoshida, Kunikazu Tanji, Tomoh Matsumiya, Fei Xing, Ryo Hayakari, Liang Wang, Kazushi Tsuruga, Hiroshi Tanaka, Junsei Mimura, Kunio Kosaka, Ken Itoh, Ippei Takahashi, Shogo Kawaguchi, Tadaatsu Imaizumi
Neuroscience research 94 1 - 9 2015.5
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Role of the Keap1/Nrf2 pathway in neurodegenerative diseases.
Hiromi Yamazaki, Kunikazu Tanji, Koichi Wakabayashi, Shin Matsuura, Ken Itoh
Pathology international 65 ( 5 ) 210 - 219 2015.5
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Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer.
Momoko Kimura, Tae Yamamoto, Jianyong Zhang, Ken Itoh, Motoki Kyo, Terue Kamiya, Hiroyuki Aburatani, Fumiki Katsuoka, Hirofumi Kurokawa, Toshiyuki Tanaka, Hozumi Motohashi, Masayuki Yamamoto
The Journal of biological chemistry 290 ( 17 ) 10644 - 10644 2015.4
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Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria.
Ken Itoh, Peng Ye, Tomoh Matsumiya, Kunikazu Tanji, Taku Ozaki
Journal of clinical biochemistry and nutrition 56 ( 2 ) 91 - 97 2015.3
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Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding.
Atsushi Maruyama, Junsei Mimura, Ken Itoh
Nucleic acids research 42 ( 22 ) 13599 - 13614 2014.12
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Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition.
Peng Ye, Junsei Mimura, Tomomi Okada, Hideyo Sato, Tao Liu, Atsushi Maruyama, Chikara Ohyama, Ken Itoh
Molecular and cellular biology 34 ( 18 ) 3421 - 3434 2014.9
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Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.
Kunikazu Tanji, Yasuo Miki, Taku Ozaki, Atsushi Maruyama, Hidemi Yoshida, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi
Acta neuropathologica communications 2 50 - 50 2014.5
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Carbocisteine reduces virus-induced pulmonary inflammation in mice exposed to cigarette smoke.
Yuichi Yageta, Yukio Ishii, Yuko Morishima, Satoshi Ano, Shigeo Ohtsuka, Masashi Matsuyama, Kaoru Takeuchi, Ken Itoh, Masayuki Yamamoto, Nobuyuki Hizawa
American journal of respiratory cell and molecular biology 50 ( 5 ) 963 - 973 2014.5
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Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.
Pengfei Meng et al.
Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells. 75 ( 2 ) 94 - 102 2013.2
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Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases.
Kunikazu Tanji et al.
J Neuropathol Exp Neurol 75 ( 2 ) 94 - 102 2013.1
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Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation.
Nobuhiko Harada et al
Free Radic Biol Med 53 ( 12 ) 2256 - 2262 2012.10
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Methylation of the KEAP1 gene promoter region in human colorectal cancer
Hanada N. et al.
BMC cancer 12 ( 66 ) 2012.2
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Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers
Yamadori T. et al.
Oncogene 2012.1
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Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes.
Mimura J. et al.
Journal of Biochemistry 150 ( 2 ) 209 - 217 2011.8
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The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response
Maruyama A. et al.
Biochemical Journal 436 ( 2 ) 387 - 397 2011.6
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Role of Nrf2 in host defense against influenza virus in cigarette smoke-exposed mice
Yageta Y. et al.
Journal of Virology 4679 ( 4690 ) 2011.5
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Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducers
Hirotsu Y. et al.
Genes to Cells 16 ( 4 ) 406 - 415 2011.4
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Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages
Harada N. et al.
Archive of Biochemistry and Biophysics 508 ( 1 ) 101 - 109 2011.4
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Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation
Yoshida H. et al.
Neuroscience Research 69 ( 4 ) 291 - 298 2011.4
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Discovery of the negative regulator of Nrf2, Keap1: a historical overview
Itoh K.et al.
Antioxidant redox signaling 13 ( 11 ) 2010.12
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Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene
Becks L. et al.
BMC cancer 10 540 2010.10
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Relationship between radiosensitivity and Nrf2 target gene expression in human hematopoietic stem cells.
Kato K
Radiation Research 174 ( 2 ) 177 - 184 2010.8
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Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response
Ichihara S. et al.
Atherosclerosis Thrombosis Vascular Biology 30 ( 8 ) 2010.8
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Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity
Liu F. et al
Toxicological science 115 ( 2 ) 2010.6
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Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance
Kikuchi N.et al.
Respiration Research 11 ( 31 ) 2010.5
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Suppression of AhR signaling pathway is associated with the down-regulation of UDP-glucuronosyltransferases during BBN-induced urinary bladder carcinogenesis in mice（共著）
Iida K他
Journal of Biochemistry 147 ( 3 ) 353 - 360 2010.3
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Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells（共著）
Kosaka K他
Journal of Biochemistry 147 ( 1 ) 73 - 81 2010.1
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Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 1（共著）
Takagaki T他
The journal of Pharmacology and Experimental Therapeutics 331 ( 1 ) 255 - 264 2009.10
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Essential role of Nrf2 in keratinocyte protection from UVA by quercetin（共著）
Kimura S他
Biochemical Biophysical Research Communications 387 109 - 114 2009.9
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Heavy ion beam irradiation regulates the mRNA expression in megakaryocytopoiesis from human hematopoietic stem/progenitor cells（共著）
Monzen S他
Journal of Radiation Research 50 ( 5 ) 477 - 486 2009.9
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Transcription factor Nrf2 mediates an adaptilve response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents（共著）
Higgins LG他
Toxicology and applied pharmacology 237 ( 3 ) 267 - 280 2009.6
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Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer（共著）
Homma S他
Clinical cancer research 15 ( 10 ) 3423 - 3432 2009.5
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Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice（共著）
Satoh T et al.
Biochemical and Biophysical Research Communications 380 ( 2 ) 298 - 302 2009.3
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Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice（共著）
Prince M. et al.
Toxicological Letter 185 ( 3 ) 180 - 186 2009.3
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Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice (共著）
Yoh K. et al.
Genes to Cells 13 ( 11 ) 1159 - 1170 2008.11
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Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements（共著）
Maruyama A. et al.
Archive of Biochemistry and Biophysics 477 ( 1 ) 139 - 145 2008.9
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Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts（共著）
Harada H. et al.
Free Radical Research 2 ( 4 ) 297 - 304 2008.7
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Keap1 Regulates the Constitutive Expression of GST A1 during Differentiation of Caco-2 Cells（共著）
Kusano Y
Biochemistry 47 ( 23 ) 6169 - 6177 2008.6
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A Possible Role of Nrf2 in Prevention of Renal Oxidative Damage by Ferric Nitrilotriacetate（共著）
Kanki K. et al.
Toxicological Pathology 36 ( 2 ) 353 - 361 2008.4
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Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners（共著）
Satoh T et al.
Neuroscience letter 434 ( 3 ) 260 - 265 2008.4
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Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein
Higgins LG et al
Toxicology and applied pharmacology 226 ( 3 ) 328 - 327 2008.2
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Carnosic acid, a catechol-type electrophilic compound, protects neuron both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of target cysteines on Keap1
Satoh T et al.
Journal of neurochemistry 104 ( 4 ) 1116 - 1131 2008.2
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Attenuation of UVB-Induced Sunburn Reaction and Oxidative DNA Damage with no Alterations in UVB-Induced Skin Carcinogenesis in Nrf2 Gene-Deficient Mice（共著）
Kawachi Y. et al.
Journal of Investigative Dermatology 128 1773 - 1779 2008.1
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Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer
Kimura M et al.
Journal of biological chemistry 282 ( 46 ) 33681 - 33690 2007.11
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Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carconogenesis
Iida K et al
Carcinogenesis 28 ( 11 ) 2398 - 2403 2007.11
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Subcellular localization and cytoplasmic complex status of endogenous Keap1
Watai Y et al
Gene to Cells 12 ( 10 ) 1163 - 1178 2007.10
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Double-stranded RNA induces galectin-9 in vascular endothelial cells:involvement of TLR3, PI3K, and IRF3 pathway
Imaizumi T et al
Glycobiology 17 ( 7 ) 12C - 15C 2007.7
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Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes
Zhang J et al
Biochemical Journal 404 ( 3 ) 459 - 466 2007.6
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Enhanced spontaneous and benzo(a)pyrene-induced mutatins in the lungs of Nrf2-deficient gpt delta mice
Aoki Y et al
Cancer Res 67 ( 12 ) 5643 - 5648 2007.6