研究者詳細 - 伊東　健

論文 - 伊東　健

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Emerging Role of GCN1 in Disease and Homeostasis.

Tatara Y, Kasai S, Kokubu D, Tsujita T, Mimura J, Itoh K

25 ( 5 ) 2998 2024年03月

Author Correction: C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.

Dayalan Naidu S, Muramatsu A, Saito R, Asami S, Honda T, Hosoya T, Itoh K, Yamamoto M, Suzuki T, Dinkova-Kostova AT

Scientific reports 14 ( 1 ) 4774 2024年02月

Role of calpain-5 in cerebral ischemia and reperfusion injury.

Chukai Y, Ito G, Miki Y, Wakabayashi K, Itoh K, Sugano E, Tomita H, Fukuda T, Ozaki T

Biochimica et biophysica acta. General subjects 1868 ( 1 ) 130506 - 130506 2024年01月

Mitochondrial Reactive Oxygen Species, Insulin Resistance, and Nrf2-Mediated Oxidative Stress Response-Toward an Actionable Strategy for Anti-Aging.

13 ( 10 ) 1544 2023年10月

Does the Protective Effect of Zinc on Telomere Length Depend on the Presence of Hypertension or Type 2 Diabetes? Results from the Iwaki Health Promotion Project, Japan.

Sato M, Wai KM, Itoh K, Yang Y, Uchikawa Y, Ito Y, Nakaji S, Ihara K

Nutrients 15 ( 20 ) 4373 - 4373 2023年10月

Individual health-disease phase diagrams for disease prevention based on machine learning

Kazuki Nakamura, Eiichiro Uchino, Noriaki Sato, Ayano Araki, Kei Terayama, Ryosuke Kojima, Koichi Murashita, Ken Itoh, Tatsuya Mikami, Yoshinori Tamada, Yasushi Okuno

Journal of Biomedical Informatics 144 104448 - 104448 2023年08月

Role of Nrf2 in 1,2-dichloropropane-induced cell proliferation and DNA damage in the mouse liver.

Kimura Y, Ekuban FA, Zong C, Sugie S, Zhang X, Itoh K, Yamamoto M, Ichihara S, Ohsako S, Ichihara G

Toxicological sciences : an official journal of the Society of Toxicology 195 ( 1 ) 28 - 41 2023年06月

Annual stability of the plasma Aß40/42 ratio and associated factors.

Nakamura T, Kawarabayashi T, Nakahata N, Itoh K, Ihara K, Nakaji S, Ikeda Y, Takatama M, Shoji M

Annals of clinical and translational neurology 10 ( 6 ) 879 - 891 2023年06月

Definition of a Dietary Pattern Expressing the Intake of Vegetables and Fruits and ItsAssociation with Intestinal Microbiota.

Yamauchi T, Koyama N, Hirai A, Suganuma H, Suzuki S, Murashita K, Mikami T, Tamada Y, Sato N, Imoto S, Itoh K, Nakaji S

15 ( 9 ) 2104 2023年04月

Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment.

Tatara Y, Yamazaki H, Katsuoka F, Chiba M, Saigusa D, Kasai S, Nakamura T, Inoue J, Aoki Y, Shoji M, Motoike IN, Tamada Y, Hashizume K, Shoji M, Kinoshita K, Murashita K, Nakaji S, Yamamoto M, Itoh K.

Curr Res Transl Med 71 ( 1 ) 103367 2023年03月

Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional Study

Nobuo Fuke, Takahiro Yamashita, Sunao Shimizu, Mai Matsumoto, Kaori Sawada, Songee Jung, Itoyo Tokuda, Mina Misawa, Shigenori Suzuki, Yusuke Ushida, Tatsuya Mikami, Ken Itoh, Hiroyuki Suganuma

Metabolites 13 ( 2 ) 250 - 250 2023年02月

Association between Advanced Glycation End-Products, Carotenoids, and Severe Erectile Dysfunction.

Fujita N, Ishida M, Iwane T, Suganuma H, Matsumoto M, Hatakeyama S, Yoneyama T, Hashimoto Y, Mikami T, Itoh K, Ohyama C

The world journal of men's health 13 ( 2 ) 250 - 711 2023年01月

Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation.

Inose-Maruyama A, Kasai S, Itoh K

Methods in molecular biology (Clifton, N.J.) 2651 157 - 166 2023年

Novel dicarbonyl metabolic pathway via mitochondrial ES1 possessing glyoxalase III activity.

Ito G, Tatara Y, Itoh K, Yamada M, Yamashita T, Sakamoto K, Nozaki T, Ishida K, Wake Y, Kaneko T, Fukuda T, Sugano E, Tomita H, Ozaki T

BBA advances 3 100092 2023年

Protective role of Nrf2 in zinc oxide nanoparticles-induced lung inflammation in female mice and sexual dimorphism in susceptibility

Toxicology letters 370 24 - 34 2022年11月

Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment

Tatara Y, Yamazaki H, Katsuoka F, Chiba M, Saigusa D, Kasai S, Nakamura T, Inoue J, Aoki Y, Shoji M, Motoike IN, Tamada Y, Hashizume K, Shoji M, Kinoshita K, Murashita K, Nakaji S, Yamamoto M, Itoh K

71 ( 1 ) 103367 - 103367 2022年10月

Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice

Shimizu S, Kasai S, Yamazaki H, Tatara Y, Mimura J, Engler MJ, Tanji K, Nikaido Y, Inoue T, Suganuma H, Wakabayashi K, Itoh K

23 ( 15 ) 2022年07月

Machine learning diagnosis by immunoglobulin N-glycan signatures for precision diagnosis of urological diseases.

Iwamura H, Mizuno K, Akamatsu S, Hatakeyama S, Tobisawa Y, Narita S, Narita T, Yamashita S, Kawamura S, Sakurai T, Fujita N, Kodama H, Noro D, Kakizaki I, Nakaji S, Itoh K, Tsuchiya N, Ito A, Habuchi T, Ohyama C, Yoneyama T

Cancer science 113 ( 7 ) 2434 - 2445 2022年07月

Impact of salivary and pancreatic amylase gene copy numbers on diabetes, obesity, and functional profiles of microbiome in Northern Japanese population.

Hasegawa T, Kakuta M, Yamaguchi R, Sato N, Mikami T, Murashita K, Nakaji S, Itoh K, Imoto S

Scientific reports 12 ( 1 ) 7628 - 7628 2022年05月

Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage

Jun Liu, Shuya Kasai, Yota Tatara, Hiromi Yamazaki, Junsei Mimura, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Sato Tsubasa, Taku Ozaki, Kunikazu Tanji, Koichi Wakabayashi, Hayato Maeda, Hiroki Mizukami, Yasuhiro Shinkai, Yoshito Kumagai, Hirofumi Tomita, Ken Itoh

International Journal of Molecular Sciences 23 ( 6 ) 2022年03月

Association of mitochondrial DNA haplogroup and hearing impairment with aging in Japanese general population of the Iwaki Health Promotion Project.

Miura S, Sasaki A, Kasai S, Sugawara T, Maeda Y, Goto S, Kasai T, Shimizume N, Jung S, Iwane T, Itoh K, Matsubara A

Journal of human genetics 67 ( 6 ) 369 - 375 2022年01月

Telomere Length and Arterial Stiffness Reflected by Brachial-Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study.

Wai KM, Kaori S, Itoh K, Shinya O, Uchikawa Y, Hayashi S, Shiraki A, Murashita K, Nakaji S, Ihara K

Journal of personalized medicine 11 ( 12 ) 2021年12月

Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction.

Zhang A, Suzuki T, Adachi S, Naganuma E, Suzuki N, Hosoya T, Itoh K, Sporn MB, Yamamoto M

Molecular and cellular biology 41 ( 11 ) e0023621 2021年10月

Age-Related Cognitive Decline and Prevalence of Mild Cognitive Impairment in the Iwaki Health Promotion Project.

Nakahata N, Nakamura T, Kawarabayashi T, Seino Y, Ichii S, Ikeda Y, Amari M, Takatama M, Murashita K, Ihara K, Itoh K, Nakaji S, Shoji M

Journal of Alzheimer's disease : JAD 84 ( 3 ) 1233 - 1245 2021年10月

多層オミックスと機械学習による軽度認知障害の予測モデルの構築

多田羅洋太, 中村智洋, 千葉満, 三枝大輔, 山嵜博未, 勝岡史城, 葛西秋宅, 川瀬倫子, 本間リナ, 松田りら, 藤本哲太, 荘司美穂, 元池育子, 玉田嘉紀, 橋爪克仁, 東海林幹夫, 木下賢吾, 伊東健

Dementia Japan 35 ( 4 ) 660 - 660 2021年10月

Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis.

Sugawara M, Abe T, Kasai S, Itoh K, Ozaki T

Biochemistry and biophysics reports 27 101101 - 101101 2021年09月

Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice.

Ekuban FA, Zong C, Takikawa M, Morikawa K, Sakurai T, Ichihara S, Itoh K, Yamamoto M, Ohsako S, Ichihara G

Toxicology 456 152785 - 152785 2021年05月

Health improvement framework for actionable treatment planning using a surrogate Bayesian model.

中村和貴, 小島諒介, 内野詠一郎, 尾野亘, 柳田素子, 村下公一, 伊東健, 中路重之, 奥野恭史

Nature communications 12 ( 1 ) 3088 - 3088 2021年05月

Capillary Electrophoresis Mass Spectrometry-Based Metabolomics of Plasma Samples from Healthy Subjects in a Cross-Sectional Japanese Population Study.

Yamamoto H, Suzuki M, Matsuta R, Sasaki K, Kang MI, Kami K, Tatara Y, Itoh K, Nakaji S

Metabolites 11 ( 5 ) 314 - 314 2021年05月

Characterization of mitochondrial calpain-5.

Chukai Y, Iwamoto T, Itoh K, Tomita H, Ozaki T

Biochimica et biophysica acta. Molecular cell research 1868 ( 5 ) 118989 - 118989 2021年04月

Association between Serum Concentration of Carotenoid and Visceral Fat.

Matsumoto M, Suganuma H, Ozato N, Shimizu S, Katashima M, Katsuragi Y, Mikami T, Itoh K, Nakaji S

Nutrients 13 ( 3 ) 912 2021年03月

The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress.

Dorion MF, Mulumba M, Kasai S, Itoh K, Lubell WD, Ong H

Oxidative medicine and cellular longevity 2021 6691402 - 6691402 2021年03月

Fe3O4-PEG-PLGAの経気道曝露による野生型およびNrf2欠損マウスの肺への影響の評価

佐藤春恵, 宗才, Stéphanie DEVINEAU, Claire MCCORD, 市原佐保子, Oliver BROOKES, Frederick Adams EKUBAN, 伊東健, 山本雅之, Sonja BOLAND, Armelle BAEZA-SQUIBAN, 市原学

日本毒性学会学術年会 48.1 ( 0 ) P-32S 2021年

JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis.

Máté János Engler, Junsei Mimura, Shun Yamazaki, Ken Itoh

FEBS open bio 10 ( 12 ) 2771 - 2779 2020年12月

特集慢性腎臓病・透析患者の酸化ストレス-最新知見と治療展開 2.慢性腎臓病における酸化ストレス進展機序(1) 慢性腎臓病におけるNrf2-Keap1 経路の役割-CKD 治療薬としての期待

伊東健, Liu Jun, 葛西秋宅

臨床透析 36 ( 12 ) 1521 - 1527 2020年11月

Prevalence of the mitochondrial 1555 A>G and 1494 C>T mutations in a community-dwelling population in Japan.

Yasunori Maeda, Akira Sasaki, Shuya Kasai, Shinichi Goto, Shin-Ya Nishio, Kaori Sawada, Itoyo Tokuda, Ken Itoh, Shin-Ichi Usami, Atsushi Matsubara

Human genome variation 7 ( 1 ) 27 - 27 2020年09月

Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging.

Sunao Shimizu, Junsei Mimura, Takanori Hasegawa, Eigo Shimizu, Seiya Imoto, Michiko Tsushima, Shuya Kasai, Hiromi Yamazaki, Yusuke Ushida, Hiroyuki Suganuma, Hirofumi Tomita, Masayuki Yamamoto, Shigeyuki Nakaji, Ken Itoh

PloS one 15 ( 8 ) e0236834 - e0236834 2020年08月

Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness.

Mai Matsumoto, Naoko Waki, Hiroyuki Suganuma, Ippei Takahashi, Sizuka Kurauchi, Kahori Sawada, Itoyo Tokuda, Mina Misawa, Masataka Ando, Ken Itoh, Kazushige Ihara, Shigeyuki Nakaji

Nutrients 12 ( 8 ) e2310 - e2310 2020年07月

Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice.

Yoshikazu Yokono, Kenji Hanada, Masato Narita, Yota Tatara, Yousuke Kawamura, Naotake Miura, Kazutaka Kitayama, Masamichi Nakata, Masashi Nozaka, Tomo Kato, Natsumi Kudo, Michiko Tsushima, Yuichi Toyama, Ken Itoh, Hirofumi Tomita

Journal of the American Heart Association 9 ( 12 ) e015616 - e015616 2020年06月

Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.

Hiromi Yamazaki, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Kunikazu Tanji, Koichi Wakabayashi, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Douglas R Cavener, Masayuki Yamamoto, Ken Itoh

PLoS genetics 16 ( 4 ) e1008693 - e1008693 2020年04月

Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease.

Tsushima M, Liu J, Hirao W, Yamazaki H, Tomita H, Itoh K

Archives of pharmacal research 43 ( 3 ) 286 - 296 2020年03月

マウスにおけるNrf2の欠損はアクリルアミドの神経毒性に対する感受性を高める

Frederick Adams EKUBAN, 宗才, 瀧川円賀, 森川浩太, 櫻井敏博, 市原佐保子, 伊東健, 山本雅之, 大迫誠一郎, 市原学

日本毒性学会学術年会 47.1 ( 0 ) P-28E 2020年

Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles.

Radwa Sehsah, Wenting Wu, Sahoko Ichihara, Naozumi Hashimoto, Yoshinori Hasegawa, Cai Zong, Ken Itoh, Masayuki Yamamoto, Ahmed Ali Elsayed, Soheir El-Bestar, Emily Kamel, Gaku Ichihara

Particle and fibre toxicology 16 ( 1 ) 47 - 47 2019年12月

定量的プロテオミクス解析による急性期放射線骨髄障害の重症化リスク因子の探索

多田羅洋太, 門前暁, 伊東健

日本生化学会大会プログラム・講演要旨集 92回 [3P - 307] 2019年09月

Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes.

Junsei Mimura, Atsushi Inose-Maruyama, Shusuke Taniuchi, Kunio Kosaka, Hidemi Yoshida, Hiromi Yamazaki, Shuya Kasai, Nobuhiko Harada, Randal J Kaufman, Seiichi Oyadomari, Ken Itoh

International journal of molecular sciences 20 ( 7 ) 1706 2019年04月

Increase of Tumor Infiltrating γδ T-cells in Pancreatic Ductal Adenocarcinoma Through Remodeling of the Extracellular Matrix by a Hyaluronan Synthesis Suppressor, 4-Methylumbelliferone.

Akiko Suto, Daisuke Kudo, Eri Yoshida, Hayato Nagase, Shinichiro Suto, Junsei Mimura, Ken Itoh, Kenichi Hakamada

Pancreas 48 ( 2 ) 292 - 298 2019年02月

Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control.

Shuya Kasai, Hiromi Yamazaki, Kunikazu Tanji, Máté János Engler, Tomoh Matsumiya, Ken Itoh

Journal of clinical biochemistry and nutrition 64 ( 1 ) 1 - 12 2019年01月

Aging and APOE-e4 are determinative factors of plasma Ab42 levels.

Takumi Nakamura, Takeshi Kawarabayashi, Yusuke Seino, Mie Hirohata, Naoko Nakahata, Sakiko Narita, Ken Itoh, Shigeyuki Nakaji, Mikio Shoji

Annals of clinical and translational neurology 5 ( 10 ) 1184 - 1191 2018年10月

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.

Sharadha Dayalan Naidu, Aki Muramatsu, Ryota Saito, Soichiro Asami, Tadashi Honda, Tomonori Hosoya, Ken Itoh, Masayuki Yamamoto, Takafumi Suzuki, Albena T Dinkova-Kostova

Scientific reports 8 ( 1 ) 8037 - 8037 2018年05月

Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease.

Shuya Kasai, Junsei Mimura, Taku Ozaki, Ken Itoh

Frontiers in veterinary science 5 242 - 242 2018年

Novel roles of glycosaminoglycans in the degradation of type I collagen by cathepsin K.

Yota Tatara, Shinichiro Suto, Ken Itoh

Glycobiology 27 ( 12 ) 1089 - 1098 2017年12月

Increase in proapoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2.

Shuya Kasai, Mary J E Richardson, Satoru Torii, Ken-Ichi Yasumoto, Hiroki Shima, Kazuhiko Igarashi, Ken Itoh, Kazuhiro Sogawa, Kazutaka Murayama

The FEBS journal 284 ( 23 ) 4115 - 4127 2017年12月

Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis.

Eiko Sakai, Masanobu Morita, Masahiro Ohuchi, Mizuho A Kido, Yutaka Fukuma, Kazuhisa Nishishita, Kuniaki Okamoto, Ken Itoh, Masayuki Yamamoto, Takayuki Tsukuba

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31 ( 9 ) 4011 - 4022 2017年09月

The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs.

Pei Y Liu, Nicholas Sokolowski, Su T Guo, Faraz Siddiqi, Bernard Atmadibrata, Thomas J Telfer, Yuting Sun, Lihong Zhang, Denise Yu, Joshua Mccarroll, Bing Liu, Rui H Yang, Xiang Y Guo, Andrew E Tee, Ken Itoh, Jenny Wang, Maria Kavallaris, Michelle Haber, Murray D Norris, Belamy B Cheung, Jennifer A Byrne, David S Ziegler, Glenn M Marshall, Marcel E Dinger, Rachel Codd, Xu D Zhang, Tao Liu

Oncotarget 7 ( 48 ) 79217 - 79232 2016年11月

The role of NUB1 in α-synuclein degradation in Lewy body disease model mice.

Kunikazu Tanji, Yasuo Miki, Atsushi Maruyama, Fumiaki Mori, Junsei Mimura, Ken Itoh, Tetsu Kamitani, Koichi Wakabayashi

Biochemical and biophysical research communications 470 ( 3 ) 635 - 642 2016年02月

Role of Nrf2 in the pathogenesis of atherosclerosis.

Junsei Mimura, Ken Itoh

Free radical biology & medicine 88 ( Pt B ) 221 - 232 2015年11月

Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.

Kunikazu Tanji, Yasuo Miki, Atsushi Maruyama, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Koichi Wakabayashi

Biochemical and biophysical research communications 465 ( 4 ) 746 - 752 2015年10月

p62 Deficiency Enhances α-Synuclein Pathology in Mice.

Kunikazu Tanji, Saori Odagiri, Yasuo Miki, Atsushi Maruyama, Yoshikazu Nikaido, Junsei Mimura, Fumiaki Mori, Eiji Warabi, Toru Yanagawa, Shinya Ueno, Ken Itoh, Koichi Wakabayashi

Brain pathology (Zurich, Switzerland) 25 ( 5 ) 552 - 564 2015年09月

Correction for Ye et al., Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition.

Peng Ye, Junsei Mimura, Tomomi Okada, Hideyo Sato, Tao Liu, Atsushi Maruyama, Chikara Ohyama, Ken Itoh

Molecular and cellular biology 35 ( 13 ) 2366 - 2366 2015年07月

Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells.

Pengfei Meng, Hidemi Yoshida, Kunikazu Tanji, Tomoh Matsumiya, Fei Xing, Ryo Hayakari, Liang Wang, Kazushi Tsuruga, Hiroshi Tanaka, Junsei Mimura, Kunio Kosaka, Ken Itoh, Ippei Takahashi, Shogo Kawaguchi, Tadaatsu Imaizumi

Neuroscience research 94 1 - 9 2015年05月

Role of the Keap1/Nrf2 pathway in neurodegenerative diseases.

Hiromi Yamazaki, Kunikazu Tanji, Koichi Wakabayashi, Shin Matsuura, Ken Itoh

Pathology international 65 ( 5 ) 210 - 219 2015年05月

Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer.

Momoko Kimura, Tae Yamamoto, Jianyong Zhang, Ken Itoh, Motoki Kyo, Terue Kamiya, Hiroyuki Aburatani, Fumiki Katsuoka, Hirofumi Kurokawa, Toshiyuki Tanaka, Hozumi Motohashi, Masayuki Yamamoto

The Journal of biological chemistry 290 ( 17 ) 10644 - 10644 2015年04月

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria.

Ken Itoh, Peng Ye, Tomoh Matsumiya, Kunikazu Tanji, Taku Ozaki

Journal of clinical biochemistry and nutrition 56 ( 2 ) 91 - 97 2015年03月

Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding.

Atsushi Maruyama, Junsei Mimura, Ken Itoh

Nucleic acids research 42 ( 22 ) 13599 - 13614 2014年12月

Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition.

Peng Ye, Junsei Mimura, Tomomi Okada, Hideyo Sato, Tao Liu, Atsushi Maruyama, Chikara Ohyama, Ken Itoh

Molecular and cellular biology 34 ( 18 ) 3421 - 3434 2014年09月

Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.

Kunikazu Tanji, Yasuo Miki, Taku Ozaki, Atsushi Maruyama, Hidemi Yoshida, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Acta neuropathologica communications 2 50 - 50 2014年05月

Carbocisteine reduces virus-induced pulmonary inflammation in mice exposed to cigarette smoke.

Yuichi Yageta, Yukio Ishii, Yuko Morishima, Satoshi Ano, Shigeo Ohtsuka, Masashi Matsuyama, Kaoru Takeuchi, Ken Itoh, Masayuki Yamamoto, Nobuyuki Hizawa

American journal of respiratory cell and molecular biology 50 ( 5 ) 963 - 973 2014年05月

Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.

Pengfei Meng et al.

Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells. 75 ( 2 ) 94 - 102 2013年02月

Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases.

Kunikazu Tanji et al.

J Neuropathol Exp Neurol 75 ( 2 ) 94 - 102 2013年01月

Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation.

Nobuhiko Harada et al

Free Radic Biol Med 53 ( 12 ) 2256 - 2262 2012年10月

Methylation of the KEAP1 gene promoter region in human colorectal cancer

Hanada N. et al.

BMC cancer 12 ( 66 ) 2012年02月

Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers

Yamadori T. et al.

Oncogene 2012年01月

Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes.

Mimura J. et al.

Journal of Biochemistry 150 ( 2 ) 209 - 217 2011年08月

The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response

Maruyama A. et al.

Biochemical Journal 436 ( 2 ) 387 - 397 2011年06月

Role of Nrf2 in host defense against influenza virus in cigarette smoke-exposed mice

Yageta Y. et al.

Journal of Virology 4679 ( 4690 ) 2011年05月

Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducers

Hirotsu Y. et al.

Genes to Cells 16 ( 4 ) 406 - 415 2011年04月

Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages

Harada N. et al.

Archive of Biochemistry and Biophysics 508 ( 1 ) 101 - 109 2011年04月

Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation

Yoshida H. et al.

Neuroscience Research 69 ( 4 ) 291 - 298 2011年04月

Discovery of the negative regulator of Nrf2, Keap1: a historical overview

Itoh K.et al.

Antioxidant redox signaling 13 ( 11 ) 2010年12月

Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene

Becks L. et al.

BMC cancer 10 540 2010年10月

Relationship between radiosensitivity and Nrf2 target gene expression in human hematopoietic stem cells.

Kato K

Radiation Research 174 ( 2 ) 177 - 184 2010年08月

Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response

Ichihara S. et al.

Atherosclerosis Thrombosis Vascular Biology 30 ( 8 ) 2010年08月

Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity

Liu F. et al

Toxicological science 115 ( 2 ) 2010年06月

Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance

Kikuchi N.et al.

Respiration Research 11 ( 31 ) 2010年05月

Suppression of AhR signaling pathway is associated with the down-regulation of UDP-glucuronosyltransferases during BBN-induced urinary bladder carcinogenesis in mice（共著）

Iida K他

Journal of Biochemistry 147 ( 3 ) 353 - 360 2010年03月

Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells（共著）

Kosaka K他

Journal of Biochemistry 147 ( 1 ) 73 - 81 2010年01月

Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 1（共著）

Takagaki T他

The journal of Pharmacology and Experimental Therapeutics 331 ( 1 ) 255 - 264 2009年10月

Essential role of Nrf2 in keratinocyte protection from UVA by quercetin（共著）

Kimura S他

Biochemical Biophysical Research Communications 387 109 - 114 2009年09月

Heavy ion beam irradiation regulates the mRNA expression in megakaryocytopoiesis from human hematopoietic stem/progenitor cells（共著）

Monzen S他

Journal of Radiation Research 50 ( 5 ) 477 - 486 2009年09月

Transcription factor Nrf2 mediates an adaptilve response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents（共著）

Higgins LG他

Toxicology and applied pharmacology 237 ( 3 ) 267 - 280 2009年06月

Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer（共著）

Homma S他

Clinical cancer research 15 ( 10 ) 3423 - 3432 2009年05月

Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice（共著）

Prince M. et al.

Toxicological Letter 185 ( 3 ) 180 - 186 2009年03月

Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice（共著）

Satoh T et al.

Biochemical and Biophysical Research Communications 380 ( 2 ) 298 - 302 2009年03月

Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice (共著）

Yoh K. et al.

Genes to Cells 13 ( 11 ) 1159 - 1170 2008年11月

Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements（共著）

Maruyama A. et al.

Archive of Biochemistry and Biophysics 477 ( 1 ) 139 - 145 2008年09月

Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts（共著）

Harada H. et al.

Free Radical Research 2 ( 4 ) 297 - 304 2008年07月

Keap1 Regulates the Constitutive Expression of GST A1 during Differentiation of Caco-2 Cells（共著）

Kusano Y

Biochemistry 47 ( 23 ) 6169 - 6177 2008年06月

A Possible Role of Nrf2 in Prevention of Renal Oxidative Damage by Ferric Nitrilotriacetate（共著）

Kanki K. et al.

Toxicological Pathology 36 ( 2 ) 353 - 361 2008年04月

Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners（共著）

Satoh T et al.

Neuroscience letter 434 ( 3 ) 260 - 265 2008年04月

Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein

Higgins LG et al

Toxicology and applied pharmacology 226 ( 3 ) 328 - 327 2008年02月

Carnosic acid, a catechol-type electrophilic compound, protects neuron both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of target cysteines on Keap1

Satoh T et al.

Journal of neurochemistry 104 ( 4 ) 1116 - 1131 2008年02月

Attenuation of UVB-Induced Sunburn Reaction and Oxidative DNA Damage with no Alterations in UVB-Induced Skin Carcinogenesis in Nrf2 Gene-Deficient Mice（共著）

Kawachi Y. et al.

Journal of Investigative Dermatology 128 1773 - 1779 2008年01月

Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer

Kimura M et al.

Journal of biological chemistry 282 ( 46 ) 33681 - 33690 2007年11月

Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carconogenesis

Iida K et al

Carcinogenesis 28 ( 11 ) 2398 - 2403 2007年11月

Subcellular localization and cytoplasmic complex status of endogenous Keap1

Watai Y et al

Gene to Cells 12 ( 10 ) 1163 - 1178 2007年10月

Double-stranded RNA induces galectin-9 in vascular endothelial cells:involvement of TLR3, PI3K, and IRF3 pathway

Imaizumi T et al

Glycobiology 17 ( 7 ) 12C - 15C 2007年07月

Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes

Zhang J et al

Biochemical Journal 404 ( 3 ) 459 - 466 2007年06月

Enhanced spontaneous and benzo(a)pyrene-induced mutatins in the lungs of Nrf2-deficient gpt delta mice

Aoki Y et al

Cancer Res 67 ( 12 ) 5643 - 5648 2007年06月

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