Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.

Hiromi Yamazaki, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Kunikazu Tanji, Koichi Wakabayashi, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Douglas R Cavener, Masayuki Yamamoto, Ken Itoh

PLoS genetics   16 ( 4 )   e1008693 - e1008693   2020年04月

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology.

Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura, Ken Itoh

Biomolecules   10 ( 2 )   2020年02月

Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes.

Junsei Mimura, Atsushi Inose-Maruyama, Shusuke Taniuchi, Kunio Kosaka, Hidemi Yoshida, Hiromi Yamazaki, Shuya Kasai, Nobuhiko Harada, Randal J Kaufman, Seiichi Oyadomari, Ken Itoh

International journal of molecular sciences   20 ( 7 )   2019年04月

Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes.

Mimura J, Inose-Maruyama A, Taniuchi S, Kosaka K, Yoshida H, Yamazaki H, Kasai S, Harada N, Kaufman RJ, Oyadomari S, Itoh K

International journal of molecular sciences   20 ( 7 )   2019年04月

Increase of Tumor Infiltrating γδ T-cells in Pancreatic Ductal Adenocarcinoma Through Remodeling of the Extracellular Matrix by a Hyaluronan Synthesis Suppressor, 4-Methylumbelliferone.

Akiko Suto, Daisuke Kudo, Eri Yoshida, Hayato Nagase, Shinichiro Suto, Junsei Mimura, Ken Itoh, Kenichi Hakamada

Pancreas   48 ( 2 )   292 - 298   2019年02月

Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease.

Shuya Kasai, Junsei Mimura, Taku Ozaki, Ken Itoh

Frontiers in veterinary science   5   242 - 242   2018年10月

Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease.

Kasai S, Mimura J, Ozaki T, Itoh K

Frontiers in veterinary science   5   242   2018年

The role of NUB1 in α-synuclein degradation in Lewy body disease model mice.

Kunikazu Tanji, Yasuo Miki, Atsushi Maruyama, Fumiaki Mori, Junsei Mimura, Ken Itoh, Tetsu Kamitani, Koichi Wakabayashi

Biochemical and biophysical research communications   470 ( 3 )   635 - 642   2016年02月

Role of Nrf2 in the pathogenesis of atherosclerosis.

Junsei Mimura, Ken Itoh

Free radical biology & medicine   88 ( Pt B )   221 - 232   2015年11月

Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.

Kunikazu Tanji, Yasuo Miki, Atsushi Maruyama, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Koichi Wakabayashi

Biochemical and biophysical research communications   465 ( 4 )   746 - 752   2015年10月

Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells.

Pengfei Meng, Hidemi Yoshida, Kunikazu Tanji, Tomoh Matsumiya, Fei Xing, Ryo Hayakari, Liang Wang, Kazushi Tsuruga, Hiroshi Tanaka, Junsei Mimura, Kunio Kosaka, Ken Itoh, Ippei Takahashi, Shogo Kawaguchi, Tadaatsu Imaizumi

Neuroscience research   94   1 - 9   2015年05月

Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells.

Meng P, Yoshida H, Tanji K, Matsumiya T, Xing F, Hayakari R, Wang L, Tsuruga K, Tanaka H, Mimura J, Kosaka K, Itoh K, Takahashi I, Kawaguchi S, Imaizumi T

Neuroscience research   94   1 - 9   2015年05月

Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding.

Atsushi Maruyama, Junsei Mimura, Ken Itoh

Nucleic acids research   42 ( 22 )   13599 - 13614   2014年12月

p62 Deficiency Enhances α-Synuclein Pathology in Mice.

Kunikazu Tanji, Saori Odagiri, Yasuo Miki, Atsushi Maruyama, Yoshikazu Nikaido, Junsei Mimura, Fumiaki Mori, Eiji Warabi, Toru Yanagawa, Shinya Ueno, Ken Itoh, Koichi Wakabayashi

Brain pathology (Zurich, Switzerland)   2014年10月

Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition.

Peng Ye, Junsei Mimura, Tomomi Okada, Hideyo Sato, Tao Liu, Atsushi Maruyama, Chikara Ohyama, Ken Itoh

Molecular and cellular biology   34 ( 18 )   3421 - 3434   2014年09月

Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.

Kunikazu Tanji, Yasuo Miki, Taku Ozaki, Atsushi Maruyama, Hidemi Yoshida, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Acta neuropathologica communications   2   50 - 50   2014年05月

Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells.

Hidemi Yoshida, Pengfei Meng, Tomoh Matsumiya, Kunikazu Tanji, Ryo Hayakari, Fei Xing, Liang Wang, Kazushi Tsuruga, Hiroshi Tanaka, Junsei Mimura, Kunio Kosaka, Ken Itoh, Ippei Takahashi, Tadaatsu Imaizumi

Neuroscience research   79   83 - 93   2014年02月

Nrf2 activation is associated with Z-DNA formation in the human HO-1 promoter.

Atsushi Maruyama, Junsei Mimura, Nobuhiko Harada, Ken Itoh

Nucleic acids research   41 ( 10 )   5223 - 5234   2013年05月

Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.

Pengfei Meng, Hidemi Yoshida, Tomoh Matsumiya, Tadaatsu Imaizumi, Kunikazu Tanji, Fei Xing, Ryo Hayakari, Junichi Dempoya, Tetsuya Tatsuta, Tomomi Aizawa-Yashiro, Junsei Mimura, Kunio Kosaka, Ken Itoh, Kei Satoh

Neuroscience research   75 ( 2 )   94 - 102   2013年02月

Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.

Meng P, Yoshida H, Matsumiya T, Imaizumi T, Tanji K, Xing F, Hayakari R, Dempoya J, Tatsuta T, Aizawa-Yashiro T, Mimura J, Kosaka K, Itoh K, Satoh K

Neuroscience research   75 ( 2 )   94 - 102   2013年02月

Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation.

Nobuhiko Harada, Koichi Ito, Tomonori Hosoya, Junsei Mimura, Atsushi Maruyama, Noriko Noguchi, Ken-Ichi Yagami, Naoki Morito, Satoru Takahashi, Jon M Maher, Masayuki Yamamoto, Ken Itoh

Free radical biology & medicine   53 ( 12 )   2256 - 2262   2012年10月

Methylation of the KEAP1 gene promoter region in human colorectal cancer.

Naoyuki Hanada, Takenori Takahata, Qiliang Zhou, Xulu Ye, Ruowen Sun, Jugoh Itoh, Atsushi Ishiguro, Hiroshi Kijima, Junsei Mimura, Ken Itoh, Shinsaku Fukuda, Yasuo Saijo

BMC cancer   12   66 - 66   2012年02月

Synphilin-1-binding protein NUB1 is colocalized with nonfibrillar, proteinase K-resistant α-synuclein in presynapses in Lewy body disease.

Kunikazu Tanji他

Journal of neuropathology and experimental neurology   70 ( 10 )   879 - 889   2011年10月

Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes.

Junsei Mimura他

Journal of Biochemistry   150 ( 2 )   209 - 217   2011年08月

The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response.

Atsushi Maruyama他

Biochemical Journal   436 ( 2 )   387 - 397   2011年06月

Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages.

Nobuhiko Harada他

Archives of Biochemistry and Biophysics   508 ( 1 )   101 - 109   2011年04月

Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation.

Hidemi Yoshida他

Neuroscience Research   69 ( 4 )   291 - 298   2011年04月

Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation.

Yoshida H, Mimura J, Imaizumi T, Matsumiya T, Ishikawa A, Metoki N, Tanji K, Ota K, Hayakari R, Kosaka K, Itoh K, Satoh K

Neuroscience research   69 ( 4 )   291 - 8   2011年04月

Discovery of the negative regulator of Nrf2, Keap1: a historical overview.

Itoh K, Mimura J, Yamamoto M

Antioxidants & redox signaling   13 ( 11 )   1665 - 78   2010年12月

Suppression of AhR signaling pathway is associated with the down-regulation of UDP-glucuronosyltransferases during BBN-induced urinary bladder carcinogenesis in mice. （共著）

Iida K, Mimura J, Itoh K, Ohyama C, Fujii-Kuriyama Y, Shimazui T, Akaza H, Yamamoto M.

Journal of Biochemistry   147 ( 3 )   353 - 360   2010年03月

Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells. （共著）

Kosaka K, Mimura J, Itoh K, Satoh T, Shimojo Y, Kitajima C, Maruyama A, Yamamoto M, Shirasawa T.

Journal of Biochemistry   147 ( 1 )   73 - 81   2010年01月

＜Symposium III＞Role of Nrf2 in the neurotrophic action of the electrophiles

Itoh Ken, Kosaka Kunio, Mimura Junsei, Satoh Takumi

弘前医学   61 ( 0 )   S63 - 69   2010年

＜Symposium V＞Edaravone and Nrf2-inducers as neuroprotective agents in human astrocytes exposed to hypoxia/reoxygenation

Yoshida Hidemi, Mimura Junsei, Imaizumi Tadaatsu, Matsumiya Tomoh, Ishikawa Akira, Metoki Norifumi, Tanji Kunikazu, Ota Ken, Kosaka Kunio, Itoh Ken, Satoh Kei

弘前医学   61 ( 0 )   S147 - 156   2010年

Hypersensitivity of aryl hydrocarbon receptor-deficient mice to lipopolysaccharide-induced septic shock.

Sekine H, Mimura J, Oshima M, Okawa H, Kanno J, Igarashi K, Gonzalez FJ, Ikuta T, Kawajiri K, Fujii-Kuriyama Y

Molecular and cellular biology   29 ( 24 )   6391 - 400   2009年12月

Hypersensitivity of aryl hydrocarbon receptor-deficient mice to lipopolysaccharide-induced septic shock. （共著）

Hiroki Sekine, Junsei Mimura, Motohiko Oshima, Hiromi Okawa, Jun Kanno, Katsuhide Igarashi, Frank J. Gonzalez, Togo Ikuta, Kaname Kawajiri, and Yoshiaki Fujii-Kuriyama

Molecular and Cellular Biology   29 ( 24 )   6391 - 6400   2009年10月

Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. （共著）

Kawajiri K, Kobayashi Y, Ohtake F, Ikuta T, Matsushima Y, Mimura J, Pettersson S, Pollenz RS, Sakaki T, Hirokawa T, Akiyama T, Kurosumi M, Poellinger L, Kato S, Fujii-Kuriyama Y.

Proceedings of the National Academy of Sciences of the United States of America   106 ( 32 )   13481 - 13486   2009年08月

Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands.

Kawajiri K, Kobayashi Y, Ohtake F, Ikuta T, Matsushima Y, Mimura J, Pettersson S, Pollenz RS, Sakaki T, Hirokawa T, Akiyama T, Kurosumi M, Poellinger L, Kato S, Fujii-Kuriyama Y

Proceedings of the National Academy of Sciences of the United States of America   106 ( 32 )   13481 - 6   2009年08月

SUMO modification regulates the transcriptional repressor function of aryl hydrocarbon receptor repressor.

Oshima M, Mimura J, Sekine H, Okawa H, Fujii-Kuriyama Y.

The Journal of biological chemistry   284 ( 17 )   11017 - 11026   2009年04月

Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs

Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, Mimura J, Kawabe Y, Hosoya T, Morita M, Shimosato D, Uchida K, Suzuki N, Yanagisawa J, Sogawa K, Rossant J, Yamamoto M, Takahashi S, Fujii-Kuriyama Y.

Cell Stem Cell   3 ( 5 )   555 - 567   2008年11月

Disruption of aryl hydrocarbon receptor (AhR) induces regression of the seminal vesicle in aged male mice

Baba T, Shima Y, Owaki A, Mimura J, Oshima M, Fujii-Kuriyama Y, Morohashi KI.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation   2 ( 1 )   1 - 11   2008年04月

Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice.

Hosoya T, Harada N, Mimura J, Motohashi H, Takahashi S, Nakajima O, Morita M, Kawauchi S, Yamamoto M, Fujii-Kuriyama Y

Biochemical and biophysical research communications   365 ( 3 )   562 - 7   2008年01月

Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice

Hosoya T, Harada N, Mimura J, Motohashi H, Takahashi S, Nakajima O, Morita M, Kawauchi S, Yamamoto M, Fujii-Kuriyama Y.

Biochemical and biophysical research communications   365 ( 3 )   562 - 567   2007年11月

Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5.

Oshima M, Mimura J, Yamamoto M, Fujii-Kuriyama Y.

Biochemical and biophysical research communications   364 ( 2 )   276 - 282   2007年10月

Unique and overlapping transcriptional roles of arylhydrocarbon receptor nuclear translocator (Arnt) and Arnt2 in xenobiotic and hypoxic responses.

Sekine H, Mimura J, Yamamoto M, Fujii-Kuriyama Y.

The Journal of biological chemistry   281 ( 49 )   37507 - 37516   2006年10月

Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes.

Fujii-Kuriyama Y, Mimura J.

Biochemical and biophysical research communications   338 ( 1 )   311 - 317   2005年12月

Effects of aryl hydrocarbon receptor signaling on the modulation of TH1/TH2 balance.

Negishi T, Kato Y, Ooneda O, Mimura J, Takada T, Mochizuki H, Yamamoto M, Fujii-Kuriyama Y, Furusako S.

Journal of immunology   175 ( 11 )   7348 - 7356   2005年12月

Effects of aryl hydrocarbon receptor signaling on the modulation of TH1/TH2 balance.

Negishi T, Kato Y, Ooneda O, Mimura J, Takada T, Mochizuki H, Yamamoto M, Fujii-Kuriyama Y, Furusako S

Journal of immunology (Baltimore, Md. : 1950)   175 ( 11 )   7348 - 56   2005年12月

Intrinsic function of the aryl hydrocarbon (dioxin) receptor as a key factor in female reproduction.

Baba T, Mimura J, Nakamura N, Harada N, Yamamoto M, Morohashi K, Fujii-Kuriyama Y.

Molecular and cellular biology   25 ( 22 )   10040 - 10051   2005年11月

Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions.

Tauchi M, Hida A, Negishi T, Katsuoka F, Noda S, Mimura J, Hosoya T, Yanaka A, Aburatani H, Fujii-Kuriyama Y, Motohashi H, Yamamoto M

Molecular and cellular biology   25 ( 21 )   9360 - 8   2005年11月

Identification of the promoter region of the parathyroid hormone receptor gene responsible for transcriptional suppression by insulin-like growth factor-I.

Kawane T, Mimura J, Fujii-Kuriyama Y, Horiuchi N.

Archives of biochemistry and biophysics   439 ( 1 )   61 - 69   2005年06月

A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis.

Kuroda M, Oikawa K, Ohbayashi T, Yoshida K, Yamada K, Mimura J, Matsuda Y, Fujii-Kuriyama Y, Mukai K.

FEBS letters   579 ( 1 )   167 - 172   2005年01月

A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis.

Kuroda M, Oikawa K, Ohbayashi T, Yoshida K, Yamada K, Mimura J, Matsuda Y, Fujii-Kuriyama Y, Mukai K

FEBS letters   579 ( 1 )   167 - 72   2005年01月

Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex.

Ogiso H, Kagi N, Matsumoto E, Nishimoto M, Arai R, Shirouzu M, Mimura J, Fujii-Kuriyama Y, Yokoyama S.

Biochemistry   43 ( 49 )   15510 - 15519   2004年12月

Expression of hypothalamic neuropeptides after acute TCDD treatment and distribution of Ah receptor repressor.

Fetissov SO, Huang P, Zhang Q, Mimura J, Fujii-Kuriyama Y, Rannug A, Hökfelt T, Ceccatelli S.

Regulatory peptides   119 ( 1-2 )   113 - 124   2004年06月

Expression of hypothalamic neuropeptides after acute TCDD treatment and distribution of Ah receptor repressor.

Fetissov SO, Huang P, Zhang Q, Mimura J, Fujii-Kuriyama Y, Rannug A, Hökfelt T, Ceccatelli S

Regulatory peptides   119 ( 1-2 )   113 - 24   2004年06月

A constitutively active arylhydrocarbon receptor induces growth inhibition of jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest.

Ito T, Tsukumo S, Suzuki N, Motohashi H, Yamamoto M, Fujii-Kuriyama Y, Mimura J, Lin TM, Peterson RE, Tohyama C, Nohara K.

The Journal of biological chemistry   279 ( 24 )   25204 - 25210   2004年06月

Biological role of AhR signaling pathway

Mimura J.

Seikagaku   76 ( 4 )   359 - 363   2004年04月

[Biological role of AhR signaling pathway].

Mimura J

Seikagaku. The Journal of Japanese Biochemical Society   76 ( 4 )   359 - 63   2004年04月

Xenobiotics and transcriptional regulation

Mimura J, Fujii-Kuriyama Y.

Tanpakushitsu kakusan koso   48 ( 16 )   2261 - 2266   2003年12月

[Xenobiotics and transcriptional regulation].

Mimura J, Fujii-Kuriyama Y

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   48 ( 16 )   2261 - 6   2003年12月

Heterodimers of bHLH-PAS protein fragments derived from AhR, AhRR, and Arnt prepared by co-expression in Escherichia coli: characterization of their DNA binding activity and preparation of a DNA complex.

Kikuchi Y, Ohsawa S, Mimura J, Ema M, Takasaki C, Sogawa K, Fujii-Kuriyama Y

Journal of biochemistry   134 ( 1 )   83 - 90   2003年07月

Modulation of oestrogen receptor signalling by association with the activated dioxin receptor.

Ohtake F, Takeyama K, Matsumoto T, Kitagawa H, Yamamoto Y, Nohara K, Tohyama C, Krust A, Mimura J, Chambon P, Yanagisawa J, Fujii-Kuriyama Y, Kato S

Nature   423 ( 6939 )   545 - 50   2003年05月

Functional role of AhR in the expression of toxic effects by TCDD.

Mimura J, Fujii-Kuriyama Y

Biochimica et biophysica acta   1619 ( 3 )   263 - 8   2003年02月

Dioxin stimulates synthesis and secretion of IgE-dependent histamine-releasing factor.

Oikawa K, Ohbayashi T, Mimura J, Fujii-Kuriyama Y, Teshima S, Rokutan K, Mukai K, Kuroda M

Biochemical and biophysical research communications   290 ( 3 )   984 - 7   2002年01月

2022年度，生化学実習，専門教育科目（学部）

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2022年度，医学研究概論I，博士一貫課程・博士後期課程

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2020年度，生化学実習，専門教育科目（学部）

2020年度，生化学（講義1），専門教育科目（学部）

2020年度，研究室研修，専門教育科目（学部）

2020年度，医学研究概論I，博士一貫課程・博士後期課程

2020年度，医学・医療の世界－人体のしくみＡ－，教養教育科目

2019年度，生物学の基礎Ⅰ（Ｂ），21世紀教育科目

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2018年度，研究室研修，専門教育科目（学部）

2018年度，医学研究概論I，博士一貫課程・博士後期課程

2018年度，医学・医療の世界－人体のしくみＡ－，教養教育科目

2018年度，基礎ゼミナール，教養教育科目

2017年度，生物学の基礎Ⅰ（Ｂ），21世紀教育科目

2017年度，研究室研修，専門教育科目（学部）

2017年度，研究室研修，専門教育科目（学部）

2017年度，統合基礎医学実習A ，専門教育科目（学部）

2017年度，医学・医療の世界－人体のしくみＡ－，教養教育科目

2017年度，基礎ゼミナール，教養教育科目

2016年度，生物学の基礎Ⅰ（Ｂ），21世紀教育科目

2016年度，基礎人体演習，専門教育科目（学部）

2016年度，研究室研修，専門教育科目（学部）

2016年度，統合基礎医学実習A ，専門教育科目（学部）

2016年度，医学研究概論I，博士一貫課程・博士後期課程

2016年度，医学・医療の世界－人体のしくみＡ－，教養教育科目

2016年度，基礎ゼミナール，教養教育科目

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2013年度，統合基礎医学実習A ，専門教育科目（学部）

2012年度，統合基礎医学実習A ，専門教育科目（学部）

2011年度，統合基礎医学実習A，専門教育科目（学部）

2009年度，統合基礎医学実習A，専門教育科目（学部）