Updated on 2021/12/08

写真a

 
NANASHIMA NAOKI
 
Affiliation
Division of Medical Science Health Science Section
Full-time staff
Health Sciences Health Sciences(Doctoral Course) Department of Bioscience and Laboratory Medicine

Degree

  • 博士(医学)

  • 修士(農学)

Research Areas

  • Life Science / Experimental pathology

  • Life Science / Structural biochemistry

  • Humanities & Social Sciences / Family and consumer sciences, and culture and living

Professional Memberships

  • 日本分子生物学会

  • 日本栄養・食糧学会

  • 健康食品管理士会

  • 日本癌学会

  • 日本生化学会

Papers

  • L.) Extract Exerts Potential Vasculoprotective Effects in Ovariectomized Rats, Including Prevention of Elastin Degradation and Pathological Vascular Remodeling.

    Kayo Horie, Naoki Nanashima, Hayato Maeda, Toshiko Tomisawa, Indrawati Oey

    Nutrients   13 ( 2 )   2021.2

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  • Comparison of Chemical Composition between Kuromoji ( Lindera umbellata) Essential Oil and Hydrosol and Determination of the Deodorizing Effect

    Naoki Nanashima, Maiko Kitajima, Shizuka Takamagi, Miyuki Fujioka, Toshiko Tomisawa

    Molecules   25 ( 18 )   2020.9

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  • ) Extract Prevents Dyslipidemia and Hepatic Steatosis in Ovariectomized Rats.

    Naoki Nanashima, Kayo Horie, Kanako Yamanouchi, Toshiko Tomisawa, Maiko Kitajima, Indrawati Oey, Hayato Maeda

    Nutrients   12 ( 5 )   2020.5

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  • Effects of Blackcurrant Anthocyanin on Endothelial Function and Peripheral Temperature in Young Smokers.

    Toshiko Tomisawa, Naoki Nanashima, Maiko Kitajima, Kasumi Mikami, Shizuka Takamagi, Hayato Maeda, Kayo Horie, Fu-Chih Lai, Tomohiro Osanai

    Molecules (Basel, Switzerland)   24 ( 23 )   2019.11

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  • Blackcurrant Extract with Phytoestrogen Activity Alleviates Hair Loss in Ovariectomized Rats.

    Naoki Nanashima, Kayo Horie

    Molecules (Basel, Switzerland)   24 ( 7 )   2019.4

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  • Phytoestrogenic Effects of Blackcurrant Anthocyanins Increased Endothelial Nitric Oxide Synthase (eNOS) Expression in Human Endothelial Cells and Ovariectomized Rats.

    Kayo Horie, Naoki Nanashima, Hayato Maeda

    Molecules (Basel, Switzerland)   24 ( 7 )   2019.3

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  • カシスの魅力と健康機能性

    前多 隼人, 西山 広亮, 小舘 めい, 福田 覚, 七島 直樹, 堀江 香代, 冨澤 登志子, 藤田 俊文, 北島 麻衣子, 加藤 陽治

    New food industry = ニューフードインダストリー : 食品加工および資材の新知識   60 ( 9 )   11 - 18   2018.9

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  • Blackcurrant Anthocyanins Increase the Levels of Collagen, Elastin, and Hyaluronic Acid in Human Skin Fibroblasts and Ovariectomized Rats.

    Naoki Nanashima, Kayo Horie, Hayato Maeda, Toshiko Tomisawa, Maiko Kitajima, Toshiya Nakamura

    Nutrients   10 ( 4 )   2018.4

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  • Single Oral Administration of Anthocyanin Rescues Smoking-Induced Endothelial Dysfunction in Young Smokers but Facilitates Oxidative Stress in Non-Smokers

    Akane Yoshizaki, Toshiko Tomisawa, Tomohiro Osanai, Naoki Nanashima, Maiko Kitajima, Kasumi Mikami, Toshifumi Fujita, Hayato Maeda, Yoji Kato

    Food and Nutrition Sciences   9 ( 3 )   179 - 190   2018.3

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  • Phytoestrogenic Activity of Blackcurrant Anthocyanins Is Partially Mediated through Estrogen Receptor Beta.

    Naoki Nanashima, Kayo Horie, Hayato Maeda

    Molecules (Basel, Switzerland)   23 ( 1 )   2017.12

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  • Anthocyanin‑rich blackcurrant extract inhibits proliferation of the MCF10A healthy human breast epithelial cell line through induction of G0/G1 arrest and apoptosis.

    Naoki Nanashima, Kayo Horie, Mitsuru Chiba, Manabu Nakano, Hayato Maeda, Toshiya Nakamura

    Molecular medicine reports   16 ( 5 )   6134 - 6141   2017.11

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  • Hair keratin KRT81 is expressed in normal and breast cancer cells and contributes to their invasiveness.

    Naoki Nanashima, Kayo Horie, Toshiyuki Yamada, Takeshi Shimizu, Shigeki Tsuchida

    Oncology reports   37 ( 5 )   2964 - 2970   2017.5

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  • Involvement of Clustered Genes in Mammalian Functions: Their Relation in a Rat Mutant Strain.

    Naoki Nanashima, Toshiyuki Yamada, Takeshi Shimizu, Shigeki Tsuchida

    Journal of molecular evolution   84 ( 4 )   159 - 161   2017.4

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  • Exosomes derived from SW480 colorectal cancer cells promote cell migration in HepG2 hepatocellular cancer cells via the mitogen-activated protein kinase pathway.

    Mitsuru Chiba, Narumi Watanabe, Miki Watanabe, Maki Sakamoto, Akika Sato, Mizuki Fujisaki, Shiori Kubota, Satoru Monzen, Atsushi Maruyama, Naoki Nanashima, Ikuo Kashiwakura, Toshiya Nakamura

    International journal of oncology   48 ( 1 )   305 - 312   2016.1

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  • Phytoestrogenic activity of blackcurrant (Ribes nigrum) anthocyanins is mediated through estrogen receptor alpha.

    Naoki Nanashima, Kayo Horie, Toshiko Tomisawa, Mitsuru Chiba, Manabu Nakano, Toshifumi Fujita, Hayato Maeda, Maiko Kitajima, Shizuka Takamagi, Daishi Uchiyama, Jun Watanabe, Toshiya Nakamura, Yoji Kato

    Molecular nutrition & food research   59 ( 12 )   2419 - 2431   2015.12

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  • Establishment of a recessive mutant small-eye rat with lens involution and retinal detachment associated with partial deletion and rearrangement of the Cryba1 gene.

    Toshiyuki Yamada, Naoki Nanashima, Takeshi Shimizu, Yosuke Nakazawa, Mitsuru Nakazawa, Shigeki Tsuchida

    The Biochemical journal   471 ( 2 )   293 - 305   2015.10

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  • Deletion of phospholipase A2 group IV c induces apoptosis in rat mammary tumor cells by the nuclear factor-κB/lipocalin 2 pathway.

    Naoki Nanashima, Toshiyuki Yamada, Takeshi Shimizu, Shigeki Tsuchida

    The Biochemical journal   2015.5

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  • Fatty acid synthase-positive hepatocytes and subsequent steatosis in rat livers by irinotecan.

    Takeyuki Sawano, Takeshi Shimizu, Toshiyuki Yamada, Naoki Nanashima, Takuya Miura, Satoko Morohashi, Daisuke Kudo, Feng Mao Hui, Hiroshi Kijima, Kenichi Hakamada, Shigeki Tsuchida

    Oncology reports   33 ( 5 )   2151 - 2160   2015.5

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  • Demonstration of Epidermal Growth Factor-like Activity in Salmon Cartilage Proteoglycan

    K. Kasai, S Fujita, T. Ishikawa, M. Nakano, M. Chiba, N. Nanashima, H. Nozaka, T. Miura, T. Nakamura.

    Journal of health science research   5   93 - 104   2015.3

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  • Demonstration of Epidermal Growth Factor-like Activity in Salmon Cartilage Proteoglycan

    Kasai K, Fujita S, Ishikawa T, Nakano M, Chiba M, Nanashima N, Nozaka H, Miura T and Nakamura T.

    Journal of health science research   5   93 - 104   2015

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  • The Report of the 2nd Educational Symposium on Radiation and Health by Young Scientists (ESRAH2015)

    Tsujiguchi Takakiyo

    Jpn. J. Radiol. Technol.   71 ( 11 )   1132 - 1137   2015

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  • OP-002-1 CPT-11によるSDラット肝のsteatosis誘発とそれに先行するKupffer細胞の減少 : CPT-11肝障害の動物モデル(OP-002 肝 基礎-2,一般演題,第114回日本外科学会定期学術集会)

    澤野 武行, 三浦 卓也, 工藤 大輔, 清水 武史, 七島 直樹, 山田 俊幸, 土田 成紀, 袴田 健一

    日本外科学会雑誌   115 ( 2 )   2014.3

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  • Lectin-like receptor Ly49s3 on dendritic cells contributes to the differentiation of regulatory T cells in the rat thymus.

    Yamada T, Nanashima N, Akita M, Shimizu T, Miura T, Yamana D, Sawano T, Sakurai T, Tsuchida S.

    J Immunology   191 ( 7 )   3799 - 3809   2013.10

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  • 4-Methylumbelliferone inhibits the phosphorylation of hyaluronan synthase 2 induced by 12-O-tetradecanoyl-phorbol-13-acetate.

    Yoshiyuki Kuroda, Kosuke Kasai, Naoki Nanashima, Hiroyuki Nozaka, Manabu Nakano, Mitsuru Chiba, Masahiko Yoneda, Toshiya Nakamura

    Biomedical research (Tokyo, Japan)   34 ( 2 )   97 - 103   2013.4

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  • Effect of X-ray Irradiation on Extracellular Matrix Components of Rat Osteoblasts and Femurs.

    Tanaka Komei, Suto Shinichiro, Kuroda Yoshiyuki, Ishikawa Takashi, Nakano Kyoko, Chiba Mitsuru, Nanashima Naoki, Nakano Manabu, Ito Koichi, Nakamura Toshiya.

    Radiation Emergency Medicine   2   43 - 49   2013.1

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  • Damage of hair follicle stem cells and alteration of keratin expression in external radiation-induced acute alopecia.

    Naoki Nanashima, Koichi Ito, Takashi Ishikawa, Manabu Nakano, Toshiya Nakamura

    International journal of molecular medicine   30 ( 3 )   579 - 584   2012.9

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  • The appearance of CD34-positive progenitor cells during rat hepatocarcinogenesis induced by peroxisome proliferator

    Shimizu Takeshi, Nanashima Naoki, Yamada Toshiyuki, Tsuchida Shigeki

    Japan Journal of Molecular Tumor Marker Research   27   17 - 18   2012

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  • Sustained repression and translocation of Ntcp and expression of Mrp4 for cholestasis after rat 90% partial hepatectomy.

    Takuya Miura, Norihisa Kimura, Toshiyuki Yamada, Takeshi Shimizu, Naoki Nanashima, Daisuke Yamana, Kenichi Hakamada, Shigeki Tsuchida

    Journal of hepatology   55 ( 2 )   407 - 414   2011.8

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  • Decrease of hepatic stellate cells in rats with enhanced sensitivity to clofibrate-induced hepatocarcinogenesis.

    Daisuke Yamana, Takeshi Shimizu, Yang Fan, Takuya Miura, Naoki Nanashima, Toshiyuki Yamada, Kenichi Hakamada, Shigeki Tsuchida

    Cancer science   102 ( 4 )   735 - 741   2011.4

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  • The multistep carcinogenesis of rat livers induced by a peroxisome proliferator clofibrate

    Shimizu Takeshi, Yamana Daisuke, Nanashima Naoki, Yamada Toshiyuki, Miura Takuya, Tsuchida Shigeki

    Japan Journal of Molecular Tumor Marker Research   26   24 - 25   2011

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  • Isolation and characterization of a novel two-component hemolysin, erylysin A and B, from an edible mushroom, Pleurotus eryngii.

    Shibata T, Kudou M, Hoshi Y, Kudo A, Nanashima N, Miyairi K

    Toxicon   56   1436 - 1442   2010.9

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  • Histone acetylation and steroid receptor coactivator expression during clofibrate-induced rat hepatocarcinogenesis.

    Jumpei Asano, Toshihiro Kudo, Takeshi Shimizu, Yang Fan, Naoki Nanashima, Daisuke Yamana, Takuya Miura, Toshiyuki Yamada, Shigeki Tsuchida

    Cancer science   101 ( 4 )   869 - 875   2010.4

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  • Glutathione S-transferase A4 is a positive marker for rat hepatic foci induced by clofibrate and genotoxic carcinogens.

    Shimizu T, Fan Y, Yamana D, Miura T, Nanashima N, Yamada T, Tsuchida S.

    Cancer Sci.   101 ( 5 )   1093 - 1098   2010.1

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  • Activation of the inactive form of marmolysin, a novel thermostable hemolysin from the edible mushroom Hypsizigus marmoreus

    Annual report of study for food under the supporting program by The Skylark Food Science Institute   ( 23 )   89 - 98   2010

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  • The analysis of transcription factors involved in GSTA4-4 expression in rat hepatic preneoplastic lesions induced by genotoxic and non-genotoxic carcinogens

    Shimizu Takeshi, Nanashima Naoki, Yamada Toshiyuki, Miura Takuya, Yamana Daisuke, Tsuchida Shigeki

    Japan Journal of Molecular Tumor Marker Research   25   29 - 30   2010

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  • Protein adsorption of ultrafine metal oxide and its influence on cytotoxicity toward cultured cells.

    Masanori Horie, Keiko Nishio, Katsuhide Fujita, Shigehisa Endoh, Arisa Miyauchi, Yoshiro Saito, Hitoshi Iwahashi, Kazuhiro Yamamoto, Hideki Murayama, Hajime Nakano, Naoki Nanashima, Etsuo Niki, Yasukazu Yoshida

    Chemical research in toxicology   22 ( 3 )   543 - 553   2009.3

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  • Physical and functional interactions between hematopoietic cell-specific ETS transcription factors and homeodomain proteins.

    Toshiyuki Yamada, Takeshi Shimizu, Takuya Sakurai, Naoki Nanashima, Fumiko Kihara-Negishi, Mitsuhiro Suzuki, Yang Fan, Miki Akita, Tsuneyuki Oikawa, Shigeki Tsuchida

    Leukemia research   33 ( 3 )   483 - 489   2009.3

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  • Ferritin expression in rat hepatocytes and Kupffer cells after lead nitrate treatment.

    Yang Fan, Toshiyuki Yamada, Takeshi Shimizu, Naoki Nanashima, Miki Akita, Kohji Suto, Shigeki Tsuchida

    Toxicologic pathology   37 ( 2 )   209 - 217   2009.2

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  • Characterization of Hair Follicles in Hirosaki Hairless Rats with Deletion of Basic Hair Keratin Genes. Enlarged Medulla, Loss of Cuticle and Long Catagen

    Akita Miki, Nanashima Naoki, Yamada Toshiyuki, Nakano Hajime, Shimizu Takeshi, Fan Yang, Tsuchida Shigeki

    The Hirosaki medical journal   60 ( 1 )   1 - 11   2009

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  • Glutathione S-transferase (GST) A4-4 is a positive marker for rat hepatic foci induced by non-genotoxic and genotoxic carcinogens

    Shimizu Takeshi, Fan Yang, Nanashima Naoki, Akita Miki, Yamada Toshiyuki, Tsuchida Shigeki

    Japan Journal of Molecular Tumor Marker Research   24   56 - 57   2009

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  • The hairless phenotype of the Hirosaki hairless rat is due to the deletion of an 80-kb genomic DNA containing five basic keratin genes.

    Naoki Nanashima, Miki Akita, Toshiyuki Yamada, Takeshi Shimizu, Hajime Nakano, Yang Fan, Shigeki Tsuchida

    The Journal of biological chemistry   283 ( 24 )   16868 - 16875   2008.6

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  • Development of glutathione S-transferase-P-negative foci accompanying nuclear factor-erythroid 2-related factor 2 expression during early stage of rat hepatocarcinogenesis.

    Yang Fan, Takeshi Shimizu, Toshiyuki Yamada, Naoki Nanashima, Miki Akita, Jumpei Asano, Shigeki Tsuchida

    Cancer science   99 ( 3 )   497 - 501   2008.3

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  • Interaction between the homeodomain protein HOXC13 and ETS family transcription factor PU.1 and its implication in the differentiation of murine erythroleukemia cells.

    Toshiyuki Yamada, Takeshi Shimizu, Mitsuhiro Suzuki, Fumiko Kihara-Negishi, Naoki Nanashima, Takuya Sakurai, Yang Fan, Miki Akita, Tsuneyuki Oikawa, Shigeki Tsuchida

    Experimental cell research   314 ( 4 )   847 - 858   2008.2

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  • Glutathione S-transferase (GST) A4-4 is a possible positive marker for preneoplastic lesions induced by peroxisome proliferators (PP)

    Shimizu Takeshi, Nanashima Naoki, Fan Yang, Akita Miki, Yamada Toshiyuki, Tsuchida Shigeki

    Japan Journal of Molecular Tumor Marker Research   23   25 - 26   2008

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  • Suppression of matrix metalloproteinase-9 by 4-methylumbelliferone.

    Rika Nakamura, Hiroko Kuwabara, Masahiko Yoneda, Shuichi Yoshihara, Takashi Ishikawa, Tomisato Miura, Hiroyuki Nozaka, Naoki Nanashima, Tatsusuke Sato, Toshiya Nakamura

    Cell biology international   31 ( 9 )   1022 - 1026   2007.9

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  • Alteration of MMP and TIMP expression in human skin fibroblasts under acidic culture conditions

    Nanashima Naoki, Ishikawa Takashi, Miura Tomisato, Nozaka Hiroyuki, Sato Tatsusuke, Nakamura Toshiya

    Bulletin of Health Sciences Hirosaki   6   135 - 139   2007

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  • For Young Researchers: Nuclear localization of STAT5A modified with O-linked N-acetylglucosamine and early involution in the mammary gland of Hirosaki hairless rat

    The Hirosaki medical journal   58 ( 1 )   56 - 58   2007

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  • Factors involved in different inducibilities of hepatic bifunctional enzyme by peroxisome proliferators in rats with polymorphic glutathione transferase gene

    Shimizu Takeshi, Asano Jumpei, Nanashima Naoki, Fan Yang, Akita Miki, Yamada Toshiyuki, Tsuchida Shigeki

    Japan Journal of Molecular Tumor Marker Research   22   18 - 19   2007

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  • Different susceptibility to peroxisome proliferator-induced hepatocarcinogenesis in rats with polymorphic glutathione transferase genes.

    Toshihiro Kudo, Jumpei Asano, Takeshi Shimizu, Naoki Nanashima, Yang Fan, Miki Akita, Keizo Ookawa, Makoto Hayakari, Yoshihito Yokoyama, Kohji Suto, Shigeki Tsuchida

    Cancer science   97 ( 8 )   703 - 709   2006.8

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  • Loss of carbonic anhydrase III expression in rat preneoplastic hepatic lesions induced by peroxisome proliferator

    Shimizu Takeshi, Kudo Toshihiro, Asano Jumpei, Nanashima Naoki, Fan Yang, Yamada Toshiyuki, Tsuchida Shigeki

    Japan Journal of Molecular Tumor Marker Research   21   43 - 44   2006

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  • Nuclear localization of STAT5A modified with O-linked N-acetylglucosamine and early involution in the mammary gland of Hirosaki hairless rat.

    Naoki Nanashima, Jumpei Asano, Makoto Hayakari, Toshiya Nakamura, Hajime Nakano, Toshiyuki Yamada, Takeshi Shimizu, Miki Akita, Yang Fan, Shigeki Tsuchida

    The Journal of biological chemistry   280 ( 52 )   43010 - 43016   2005.12

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  • Effect of cell-surface glycosaminoglycans on the activity of hyaluronan-depolymerizing enzyme

    Nakamura Toshiya, Nanashima Naoki, Nozaka Hiroyuki, Nakaoka Rie, Miura Tomisato, Ishikawa Takashi, Sato Tsuyoshi

    Bulletin of Health Sciences Hirosaki   2   73 - 78   2003

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  • 4-Methylumbelliferone induces the expression of membrane type 1-matrix metalloproteinase in cultured human skin fibroblasts.

    Toshiya Nakamura, Takashi Ishikawa, Naoki Nanashima, Tomisato Miura, Hiroyuki Nozaka, Rie Nakaoka, Tatsusuke Sato

    Biochemical and biophysical research communications   298 ( 5 )   646 - 650   2002.11

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Books

  • 弘前大学レクチャーコレクション

    弘前大学出版会編( Role: Contributor ,  ヒロサキヘアレスラット)

    弘前大学出版会  2020.3 

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    Language:Japanese Book type:General book, introductory book for general audience

Review Papers

  • 認定校紹介シリーズ

    七島 直樹

    日本食品安全協会会誌   14 ( 4 )   333 - 334   2019.10

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  • 第1回研修会・市民公開講座報告

    七島 直樹

    日本食品安全協会会誌協会   14 ( 3 )   253 - 254   2019.7

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    Language:Japanese   Publishing type:Meeting report   Kind of work:Single Work  

  • Phospholipase A2 group IVc blocks mammary tumor apoptosis

    Naoki Nanashima, Toshiyuki Yamada, Shigeki Tsuchida

    ATLAS of Science   2015.11

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  • Deletion of phospholipase A2 group IVc induces apoptosis in rat mammary tumour cells by the nuclear factor-kB/lipocalin 2 pathway

    七島 直樹、山田 俊幸、清水 武史、土田 成紀

    日本人論文紹介(ユサコHP内)    2015.7

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    Language:Japanese   Kind of work:Joint Work  

Awards

  • 弘前大学若手優秀論文賞

    2018.02

  • 日本生化学会東北支部優秀論文賞

    2009.05

  • 第11回 弘前大学医学部学術奨励賞

    2007.01

Social Activities

  • 弘前医療福祉大学短期大学部 非常勤講師

    2018.04 - 2019.08

  • 弘大ナビゲートin青森東高校

    2016.06

  • 弘前病院附属看護学校 非常勤講師

    2011.08

  • 弘前市医師会看護専門学校 非常勤講師

    2003.08

Media Coverage

  • こうぎょくカレッジ

    2019.08