Updated on 2024/03/27

写真a

 
KASAI KOSUKE
 
Affiliation
Health Sciences Health Sciences(Doctoral Course) Department of Bioscience and Laboratory Medicine

Degree

  • 博士(保健学)

  • 修士(保健学)

  • 学士(農学)

Professional Memberships

  • 日本生化学会

  • 日本分子生物学会

Papers

  • Antimicrobial properties of L-amino acid oxidase: biochemical features and biomedical applications.

    Kasai K, Nakano M, Ohishi M, Nakamura T, Miura T

    Applied microbiology and biotechnology   105 ( 12 )   4819 - 4832   2021.6

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    PubMed

  • Phosphorylation of Thr 328 in hyaluronan synthase 2 is essential for hyaluronan synthesis

    Kasai K, Kuroda Y, Takabuchi Y, Nitta A, Kobayashi T, Nozaka H, Miura T, Nakamura T.

    Biochem Biophys Res Commun.   533 ( 4 )   732 - 738   2020.12

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  • Metal coordination by L-amino acid oxidase derived from flounder Platichthys stellatus is structurally essential and regulates antibacterial activity.

    Kasai K, Ito Y, Nitta A, Ariyoshi K, Nakamura T, Miura T.

    Appl Microbiol Biotechnol.   104 ( 22 )   9645 - 9654   2020.11

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  • Antibacterial properties of L-amino acid oxidase: mechanisms of action and perspectives for therapeutic applications.

    K. Kasai, T. Ishikawa, T. Nakamura, T. Miura.

    Applied Microbiology and Biotechnology   99 ( 19 )   7847 - 7857   2015.10

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  • Recombinant production and evaluation of an antibacterial L-amino acid oxidase derived from flounder Platichthys stellatus

    Kosuke Kasai, Kenro Hashiguchi, Hiroki Takahashi, Ayano Kasai, Sadanori Takeda, Manabu Nakano, Takashi Ishikawa, Toshiya Nakamura, Tomisato Miura

    Applied Microbiology and Biotechnology   2015.2

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  • Novel L-amino acid oxidase with antibacterial activity against methicillin-resistant Staphylococcus aureus isolated from epidermal mucus of the flounder Platichthys stellatus

    Kosuke Kasai, Takashi Ishikawa, Takafumi Komata, Kaori Fukuchi, Mitsuru Chiba,Hiroyuki Nozaka, Toshiya Nakamura, Tatsusuke Sato, Tomisato Miura

    FEBS Journal   277 ( 2 )   453 - 465   2010.1

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  • Optimizing chemical-induced premature chromosome condensation assay for rapid estimation of high-radiation doses

    Ryo Nakayama, Donovan Anderson, Valerie Swee Ting Goh, Yohei Fujishima, Kaito Yanagidate, Kentaro Ariyoshi, Kosuke Kasai, Mitsuaki A Yoshida, William F Blakely, Tomisato Miura

    Radiation Protection Dosimetry   2024.1

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  • Cytogenetic Biodosimetry in Radiation Emergency Medicine: 5. The Dicentric Chromosome and its Role in Biodosimetry

    Anderson Donovan, Abe Yu, Goh Swee Ting Valerie, Nakayama Ryo, Takebayashi Kai, Tran Thanh Mai, Fujishima Yohei, Nakata Akifumi, Ariyoshi Kentaro, Kasai Kosuke, A. Yoshida Mitsuaki, Miura Tomisato

    Radiation Environment and Medicine   12 ( 2 )   121 - 139   2023.8

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    CiNii Research

  • Vibratome technique revealed initial carcinogenic changes that induce GST-P+ single hepatocytes and minifoci in rat liver.

    Kimihiko Satoh, Daishi Yamakawa, Kosuke Kasai, Ichiro Hatayama

    Analytical biochemistry   672   115168 - 115168   2023.7

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  • Exosome-like vesicles released from ob/ob mouse adipose tissue enhance cell survival of cells with radiation-induced genomic instability.

    Ariyoshi K, Fujishima Y, Goh VST, Nakata A, Kasai K, Yoshida MA, Miura T.

    J Radiat Res.   23 ( 64(2) )   352 - 357   2023.3

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  • Manual Scoring with Shortened 48 h Cytokinesis-Block Micronucleus Assay Feasible for Triage in the Event of a Mass-Casualty Radiation Accident

    Goh VST, Fujishima Y, Nakayama R, Takebayashi K, Yoshida MA, Kasai K, Ariyoshi K, Miura T.

    2023.2

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  • Chondroitin sulfate is not digested at all in the mouse small intestine but may suppress interleukin 6 expression induced by tumor necrosis factor-α.

    Kudo K, Kobayashi T, Kasai K, Nozaka H, Nakamura T.

    Biochem Biophys Res Commun.   29 ( 642 )   185 - 191   2023.1

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  • Mitotic index maximization with no effect on radiation-induced dicentric chromosome frequency.

    Takebayashi K, Echizenya K, Kameya Y, Nakajima D, Nakayama R, Fujishima Y, Goh VST, Abe Y, Kasai K, Anderson DA, Blakely WF, Miura T.

    Int J Radiat Biol.   9   1 - 10   2022.11

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  • Cytogenetic Biodosimetry in Radiation Emergency Medicine: 4. Overview of Cytogenetic Biodosimetry

    Ryo Nakayama, Yu Abe, Valerie Goh Swee Ting, Kai Takebayashi, Mai Tran Thanh, Yohei Fujishima, Akifumi Nakata, Kentaro Ariyoshi, Kosuke Kasai, Donovan Anderson, Hiroyuki Hanada, Mitsuaki A. Yoshida, Katsuhiro Ito and Tomisato Miura

    Radiation Environment and Medicine   11 ( 2 )   91 - 103   2022.9

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  • Cytogenetic Biodosimetry in Radiation Emergency Medicine: 3. The Basics of Chromosomes for Biodosimetry

    Akifumi Nakata, Kentaro Ariyoshi, Yu Abe, Yohei Fujishima, Valerie Goh Swee Ting, Ryo Nakayama, Kai Takebayashi, Mai Tran Thanh, Kosuke Kasai, Mitsuaki A. Yoshida and Tomisato Miura

    Radiation Environment and Medicine   11 ( 2 )   82 - 90   2022.9

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  • Evaluation of sperm fertilization capacity of large Japanese field mice (Apodemus speciosus) exposed to chronic low dose-rate radiation after the Fukushima accident

    Kazu Nihei, Syun Tokita, Hideaki Yamashiro, Valerie Goh Swee Ting, Ryo Nakayama, Yohei Fujishima, Yasushi Kino, Yoshinaka Shimizu, Hisashi Shinoda, Kentaro Ariyoshi, Kosuke Kasai, Yasuyuki Abe, Manabu Fukumoto, Akifumi Nakata, Tomisato Miura

    Journal of Radiation Research and Applied Sciences   15 ( 3 )   186 - 190   2022.9

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  • Cytogenetic Biodosimetry in Radiation Emergency Medicine: 2. Biosafety and Chemical Safety in Biodosimetry Laboratory

    K. Kasai Y. Abe, Valerie Goh Swee Ting, MT. Thanh, Y. Fujishima, R. Nakayama, K. Takebayashi, A. Nakata, K. Ariyoshi, H. Hanada, MA. Yoshida, K. Ito and T. Miura5

    Radiation Environment and Medicine   11 ( 1 )   34 - 39   2022.3

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  • Cytogenetic Biodosimetry in Radiation Emergency Medicine: 1. Blood Collection and Its Management

    Y. Fujishima, Y. Abe, Valerie Goh Swee Ting, R. Nakayama, K. Takebayashi, A. Nakata, K. Ariyoshi, MT Thanh, K. Kasai, H. Hanada, MA. Yoshida, K. Ito and T. Miura

    11 ( 1 )   25 - 33   2022.3

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  • Assessment of chromosome aberrations in large Japanese field mice (Apodemus speciosus) in Namie Town, Fukushima.

    Fujishima Y, Nakata A, Ujiie R, Kasai K, Ariyoshi K, Goh VST, Suzuki K, Tazoe H, Yamada M, Yoshida MA, Miura T.

    Int J Radiat Biol.   98 ( 6 )   1159 - 1167   2022

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  • Environmental radiation on large Japanese field mice in Fukushima reduced colony forming potential in hematopoietic progenitor cells without inducing genomic instability.

    Ariyoshi K, Miura T, Kasai K, Goh VST, Fujishima Y, Nakata A, Takahashi A, Shimizu Y, Shinoda H, Yamashiro H, Seymour C, Mothersill C, Yoshida MA.

    98 ( 6 )   1147 - 1158   2022

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  • Cytokinesis-block micronucleus assay performed in 0 and 2 Gy irradiated whole blood and isolated PBMCs in a six-well transwell co-culture system.

    Goh VST, Takebayashi K, Nakayama R, Fujishima Y, Yoshida MA, Kasai K, Ariyoshi K, Miura T.

    97 ( 12 )   1631 - 1640   2021.9

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  • Human Resource Development for Cytogenetic Biodosimetry at Hirosaki University

    Miura Tomisato, Kasai Kosuke, Abe Yu, Fujishima Yohei, Ting Valerie Goh Swee, Nakayama Ryo, Takebayashi Kai, Sasaki Naomi, Ariyoshi Kentaro, Nakata Akifumi, Tsujiguchi Takakiyo, Ito Katsuhiro, Hanada Hiroyuki, Yoshida Mitsuaki A.

    Radiation Environment and Medicine   10 ( 2 )   102 - 107   2021.8

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    CiNii Research

  • Morphological reproductive characteristics of testes and fertilization capacity of cryopreserved sperm after the Fukushima accident in raccoon (Procyon lotor).

    Komatsu K, Iwasaki T, Murata K, Yamashiro H, Goh VST, Nakayama R, Fujishima Y, Ono T, Kino Y, Simizu Y, Takahashi A, Shinoda H, Ariyoshi K, Kasai K, Suzuki M, Palmerini MG, Belli M, Macchiarelli G, Oka T, Fukumoto M, Yoshida MA, Nakata A, Miura T.

    Reprod Domest Anim.   56 ( 3 )   484 - 497   2021.3

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  • Transition of Radioactive Cesium Deposition in Reproductive Organs of Free-Roaming Cats in Namie Town, Fukushima.

    Fujishima Y, Kino Y, Ono T, Goh VST, Nakata A, Ariyoshi K, Kasai K, Toyoda T, Akama T, Tazoe H, Yamada M, Yoshida MA, Miura T.

    Int J Environ Res Public Health.   18 ( 4 )   1772   2021.2

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  • Extracellular vesicles released from irradiated neonatal mouse cheek tissue increased cell survival after radiation.

    Ariyoshi K, Hiroyama Y, Fujiwara N, Miura T, Kasai K, Nakata A, Fujishima Y, Ting Goh VS, Yoshida MA.

    J Radiat Res.   62 ( 1 )   73 - 78   2021.1

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  • Improved harvest and fixation methodology for isolated human peripheral blood mononuclear cells in cytokinesis-block micronucleus assay.

    Goh VST, Nakayama R, Blakely WF, Abe Y, Chua CEL, Chew ZH, Nakata A, Fujishima Y, Yoshida MA, Kasai K, Ariyoshi K, Miura T.

    Int J Radiat Biol.   97 ( 2 )   194 - 207   2021

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  • Phosphorylation of Thr<sup>328</sup> in hyaluronan synthase 2 is essential for hyaluronan synthesis.

    Kasai K, Kuroda Y, Takabuchi Y, Nitta A, Kobayashi T, Nozaka H, Miura T, Nakamura T

    Biochemical and biophysical research communications   533 ( 4 )   732 - 738   2020.12

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  • Environmental radiation on large Japanese field mice in Fukushima reduced colony forming potential in hematopoietic progenitor cells without inducing genomic instability.

    Ariyoshi K, Miura T, Kasai K, Goh VST, Fujishima Y, Nakata A, Takahashi A, Shimizu Y, Shinoda H, Yamashiro H, Seymour C, Mothersill C, Yoshida MA.

    Int J Radiat Biol.   20   1 - 12   2020.8

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  • Assessment of chromosome aberrations in large Japanese field mice (<i>Apodemus speciosus</i>) in Namie Town, Fukushima.

    Fujishima Y, Nakata A, Ujiie R, Kasai K, Ariyoshi K, Goh VST, Suzuki K, Tazoe H, Yamada M, Yoshida MA, Miura T

    International journal of radiation biology   1 - 9   2020.7

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  • Assessment of chromosome aberrations in large Japanese field mice (Apodemus speciosus) in Namie Town, Fukushima.

    Fujishima Y, Nakata A, Ujiie R, Kasai K, Ariyoshi K, Goh VST, Suzuki K, Tazoe H, Yamada M, Yoshida MA, Miura T.

    Int J Radiat Biol.   20   1 - 9   2020.7

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  • Analysis of Radioactive Elements in Testes of Large Japanese Field Mice Using an Electron Probe Micro-Analyser after the Fukushima Accident

    Takuya Ohdaira, Kanna Meguro, Kazuki Komatsu, Rina Syoji, Yohei Fujishima, Valerie Swee Ting Goh, Kosuke Kasai, Kentaro Ariyoshi, Akifumi Nakata, Yusuke Urushihara, Kazuma Koarai, Yasushi Kino, Tsutomu Sekine, Masatoshi Suzuki, Atsushi Takahasi, Yoshinaka Shimizu, Hisashi Shinoda, Mitsuaki A. Yoshida, Manabu Fukumoto, Hideaki Yamashiro, Tomisato Miura

    Ionizing and Non-ionizing Radiation   2020.1

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  • Construction of Fluorescence in Situ Hybridization (FISH) Translocation Dose-Response Calibration Curve With Multiple Donor Data Sets Using R, Based on ISO 20046:2019 Recommendations

    Goh VST, Fujishima Y, Abe Y, Sakai A, Yoshida MA, Ariyoshi K, Kasai K, Wilkins RC, Blakely WF, Miura T.

    Int J Radiat Biol.   95 ( 12 )   1668 - 1684   2019.12

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  • Radiation-Induced Bystander Effect is Mediated by Mitochondrial DNA in Exosome-Like Vesicles.

    Ariyoshi K, Miura T, Kasai K, Fujishima Y, Nakata A, Yoshida M

    Sci Rep.   9 ( 1 )   9103   2019.6

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  • Influence of anticoagulants and storage temperatures on blood counts and mitotic index of blood samples collected for cytogenetic biodosimetry.

    Fujishima Y, Kanahama S, Hagino S, Natsubori S, Saito H, Azumaya A, Ariyoshi K, Nakata A, Kasai K, Yamada K, Mariya Y, Yoshida MA, Miura T.

    International Journal of Radiation Biology   95 ( 2 )   186 - 192   2019.2

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  • Age Dependence of Radiation-Induced Genomic Instability in Mouse Hematopoietic Stem Cells.

    Ariyoshi K, Miura T, Kasai K, Akifumi N, Fujishima Y, Yoshida MA.

    Radiation Research   2018.10

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  • First report of the isolation of Balamuthia mandrillaris in the northern region of Japan.

    Yamanouchi K, Arima H, Sakamoto Y, Kanto K, Kasai K, Ito K, Inaba T.

    Parasitology Research   117 ( 9 )   2895 - 2900   2018.9

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  • Radiation-induced bystander effect in large Japanese field mouse (Apodemus speciosus) embryonic cells.

    Ariyoshi K, Miura T, Kasai K, Akifumi N, Fujishima Y, Yoshida MA.

    Radiation and Environmental Biophysics   57 ( 3 )   223 - 231   2018.8

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  • UDP/P2Y6 receptor signaling regulates IgE-dependent degranulation in human basophils.

    Nakano M, Ito K, Yuno T, Soma N, Aburakawa S, Kasai K, Nakamura T, Takami H.

    Allergology International   2017.3

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  • Rapid isolation of murine primary hepatocytes for chromosomal analysis.

    Ariyoshi K, Fujishima Y, Miura T, Shang Y, Kakinuma S, Yoshiya S, Kasai K, Nakata A, Tachibana A, Yoshida MA.

    In Vitro Cellular & Developmental Biology - Animal   2017.2

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  • Analysis of the Effect of Chronic and Low-Dose Radiation Exposure on Spermatogenic Cells of Male Large Japanese Field Mice ( Apodemus speciosus ) after the Fukushima Daiichi Nuclear Power Plant Accident.

    Takino S, Yamashiro H, Sugano Y, Fujishima Y, Nakata A, Kasai K, Hayashi G, Urushihara Y, Suzuki M, Shinoda H, Miura T, Fukumoto M.

    Radiation Research   187 ( 2 )   161 - 168   2017.2

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  • Induction of genomic instability and activation of autophagy in artificial human aneuploid cells.

    Ariyoshi K, Miura T, Kasai K, Fujishima Y, Oshimura M, Yoshida MA

    Mutation Research   790   19 - 30   2016.8

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  • 魚類粘液L-アミノ酸オキシダーゼの選択的抗菌スペクトル

    葛西宏介, 高橋弘樹, 橋口研朗, 武田貞徳, 石川孝, 三浦富智

    保健科学研究   5   2015.2

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  • Demonstration of epidermal growth factor-like activity in salmon cartilage proteoglycans

    K. Kasai, S. Fujita, T. Ishikawa, M. Nakano, M. Chiba, N. Nanashima, H. Nozaka, T. Miura, T. Nakamura

    Journal of health science research   5   2015.2

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  • A novel parameter, cell-cycle progression index, for radiation dose absorbed estimation in the premature chromosome condensation assay.

    T. Miura, A Nakata, K. Kasai, M. Nakano, Y. Abe, E. Tsushima, NI Ossetrova, MA Yoshida, WF Blakely

    Radiation Protection Dosimetry   1 - 9   2014.6

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  • Healthcare of 18 workers who supported the regulation of radiological contaminations at the fukushima daiichi nuclear power plant

    T. Miura, A. Nakata, K. Kasai, Y. Abe, Y. Jin, M. A. Yoshida

    Radiat. Emerg. Med.   2 ( 2 )   63 - 67   2013.7

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  • 4-Methylumbelliferone inhibits the phosphorylation of hyaluronan synthase 2 by 12-O-tetradecanoyl-phorbol-13-acetate.

    Y. Kuroda, K. Kasai, N. Nanashima, H. Nozaka, M. Nakano, M. Chiba, M. Yoneda, T. Nakamura.

    Biomed. Res.   34 ( 2 )   2013.3

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  • Nonclonal growth of preneoplastic cells positive for glutathione S-transferase P-form in the rat liver.

    K. Satoh, D. Yamakawa, K. Kasai, M. Hayakari, K. Uchida, T. Miura.

    Cancer Sci.   103 ( 8 )   1445 - 1450   2012.8

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  • Identification of up-regulated and down-regulated cis-natural antisense transcripts in the human B lymphoblastic cell line IM-9 after X-ray irradiation.

    M. Chiba, T. Miura, K. Kasai, S. Monzen, I. Kashiwakura, H. Yasue, T. Nakamura.

    Mol Med Rep.   5 ( 5 )   1151 - 1157   2012.5

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  • Identification of up/down-regulated cis-natural antisense transcripts in the human B lymphoblastic cell line IM-9 by X- ray irradiation

    M. chiba, T. Miura, K. Kasai, S. Monzen, I. Kashiwakura, H. Yasue, T. Nakamura

    Mol Med Rep   5 ( 5 )   1151 - 1157   2012.2

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  • Effects of colcemid-block on chromosome condensation in metaphase analysis and premature chromosome condensation assays

    T. Miura, A. Nakata, K. Kasai, M. Yoshida

    Radiat Emerg Med   1   70 - 74   2012.1

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  • Anti-inflammatory effect of proteoglycan and progesterone on human uterine cervical fibroblasts

    A. Fukuyama, K. Tanaka, I. Kakizaki, K. Kasai, M. Chiba, T. Nakamura, H. Mizunuma

    Life Sci   90   484 - 488   2011.12

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  • Rapid Diagnostic Method for the Detection of Diarrheagenic Escherichia coli by Multiplex PCR

    Miyuki Fujioka, Kosuke Kasai, Tomisato Miura, Tatsusuke Sato, Yoshimitsu Otomo

    Japanese Journal of Infectious Diseases   62 ( 6 )   476 - 480   2009.11

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  • Hepatoid carcinoma of the skin: spontaneous rat skin hepatoid carcinoma with eosinophilic globules and crystals immunoreactive to alpha-1-antitrypsin.

    Sutoh M, Chiba M, Kasai K, Miura T, Nozaka H, Washiya K, Okusawa E, Oyama N, Tsutaya C, Tsushima M, Terayama Y, Funyu T, Sato T

    Medical molecular morphology   42 ( 2 )   118 - 22   2009.6

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  • Hepatoid carcinoma of the skin: spontaneous rat skin hepatoid carcinoma with eosinophilic globules and crystals immunoreactive to α-1-antitrypsin.

    Mihoko Sutoh, Mitsuru Chiba, Kosuke Kasai, Tomisato Miura, Hiroyuki Nozaka, Kiyotada Washiya, Etuko Okusawa, Naoto Oyama, Chikako Tsutaya, Megumi Tsushima, Yuriko Terayama, Tomihisa Funyu, Tatsusuke Sato

    Medical Molecular Morphology   42   118 - 122   2009.2

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  • Expression of HER-2/neu splice variants in the human breast cancer cells

    Arai C, Miura T, Kasai K,Chiba M, Nozaka H, Kazama R, Muramatsu A, Sato T

    Modern Pathology   21 ( S1 )   19A - 19A   2008.1

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  • Her-2/neu splicing variants expression in human breast cancer : Comparison of RT-PCR and Immunohistochemistry and Fluorescence in situ hybridization.

    Nozaka H, Kazama R, Kouga H, Muramatsu A, Arai C, Zheng Z, Miura T, Kasai K, Sato T, Okusawa E, Katayama Y, Uesugi N, Sugai T, Nakamura S

    Modern Patholog   21 ( S1 )   47A - 47A   2008.1

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  • Apple Procyanidins Induce Tumor-Cell Apoptosis through Mitochondrial Pathway Activation of Caspase-3.

    Tomisato Miura, Mituru Chiba, Kosuke Kasai, Hiroyuki Nozaka, Toshihiko Shoji, Tomomasa Kanda, Yasuyuki Ohtake, and Tatusuke Sato

    Carcinogenesis   29 ( 3 )   585 - 593   2007.9

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  • Structural features of GmIRCHS, candidate of the I gene inhibiting seed coat pigmentation in soybean:implications for inducing endogenous RNA silencing of chalcone synthase genes.

    Atsushi Kasai, Kosuke Kasai, Setuzo Yumoto, Mineo Senda

    Plant Molecular Biology   64 ( 4 )   467 - 479   2007.5

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  • The analysis of apoptosis mechanism by the apple procyanidins in the mouse mammary tumor cells

    Miura T, Chiba M, Kasai k, Nozaka H, Shoji T, Kanda T, Otake Y, Sato T

    Polyphenols Communications 2006   547 - 548   2006.8

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