Affiliation
Graduate School of Science and Technology Research Division
HAGIHARA Masaki
Degree
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博士（エネルギー科学）
Research Interests
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Bioorganic Chemistry
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Nucleic Acids Chemistry
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ケミカルバイオロジー
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グアニン四重鎖
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antisense
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RNA
Research Areas
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Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules
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Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules
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Nanotechnology/Materials / Bio chemistry
Professional Memberships
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日本薬学会
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日本ケミカルバイオロジー学会
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日本化学会
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JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
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THE CHEMICAL SOCIETY OF JAPAN
Papers
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Small molecule-based detection of non-canonical RNA G-quadruplex structures that modulate protein translation
Yousuke Katsuda, Shin-ichi Sato, Maimi Inoue, Hisashi Tsugawa, Takuto Kamura, Tomoki Kida, Rio Matsumoto Sefan Asamitsu, Norifumi Shioda, Shuhei Shiroto, Yoshiki Oosawatsu, Kenji Yatsuzuka, Yusuke Kitamura, Masaki Hagihara, Toshihiro Ihara and Motonari Uesugi
Nucleic Acids Research 50 ( 14 ) 8143 - 8153 2022.7
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Short Tandem Repeat Contractions during In Vitro DNA Synthesis by Repeat-binding Molecules
Hagihara Masaki, Dohno Chikara, Saito Kaoru, Sugimoto Kazuhiro, Hishinuma Yuta, Sohma Yuri, Shibata Tomonori, Nakatani Kazuhiko
Chemistry Letters 50 ( 11 ) 1848 - 1851 2021.11
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Guanine-tethered Oligonucleotides Restore Abnormal Protein Synthesis with a SNP Mutation in a 5′-UTR G-quadruplex of Human MSH2
Hagihara Masaki, Shiroto Shuhei, Igarashi Shunya, Sato Shin-ichi
Chemistry Letters 50 ( 10 ) 1806 - 1809 2021.10
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Inhibition of protein synthesis through RNA-based tandem G-quadruplex formation.
Hagihara M
Chemical communications (Cambridge, England) 57 ( 65 ) 8063 - 8066 2021.8
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Small molecule-induced trinucleotide repeat contractions during in vitro DNA synthesis.
Chikara Dohno, Masaki Hagihara, Nursakinah Binti Mohd Zaifuddin, Mizuki Nihei, Kaoru Saito, Kazuhiko Nakatani
Chemical communications (Cambridge, England) 57 ( 26 ) 3235 - 3238 2021.3
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Structures and Catalytic Activities of Complexes between Heme and All Parallel-Stranded Monomeric G-Quadruplex DNAs
Yasuhiko Yamamoto, Haruka Araki, Ryosuke Shinomiya, Kosuke Hayasaka, Yusaku Nakayama, Kentaro Ochi, Tomokazu Shibata, Atsuya Momotake, Takako Ohyama, Masaki Hagihara, and Hikaru Hemmi
Biochemistry 57 ( 41 ) 5938 - 5948 2018.9
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Structures and Catalytic Activities of Complexes between Heme and All Parallel-Stranded Monomeric G‐Quadruplex DNAs
Yasuhiko Yamamoto, Haruka Araki, Ryosuke Shinomiya, Kosuke Hayasaka, Yusaku Nakayama, Kentaro Ochi, Tomokazu Shibata, Atsuya Momotake, Takako Ohyama, Masaki Hagihara, Hikaru Hemmi
Biochemistry, in press 2018
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A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA
Yousuke Katsuda, Shin-ichi Sato, Lisa Asano, Yoshitaka Morimura, Tomoyuki Furuta, Hiroshi Sugiyama, Masaki Hagihara, Motonari Uesugi
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 138 ( 29 ) 9037 - 9040 2016.7
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G-Quadruplex DNA- and RNA-Specific-Binding Proteins Engineered from the RGG Domain of TLS/FUS
Kentaro Takahama, Arisa Miyawaki, Takumi Shitara, Keita Mitsuya, Masayuki Morikawa, Masaki Hagihara, Katsuhito Kino, Ayumu Yamamoto, Takanori Oyoshi
ACS CHEMICAL BIOLOGY 10 ( 11 ) 2564 - 2569 2015.11
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Recognition of Chelerythrine to Human Telomeric DNA and RNA G-quadruplexes
Li-Ping Bai, Masaki Hagihara, Kazuhiko Nakatani, Zhi-Hong Jiang
Scientific Reports 2014.10
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Recognition of Chelerythrine to Human Telomeric DNA and RNA G-quadruplexes
Li-Ping Bai, Masaki Hagihara, Kazuhiko Nakatani, Zhi-Hong Jiang
SCIENTIFIC REPORTS 4 6767 2014.10
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Formation of a Ligand- Assisted Complex of Two RNA Hairpin Loops
Changfeng Hong, Takahiro Otabe, Saki Matsumoto, Chikara Dohno, Asako Murata, Masaki Hagihara, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL 20 ( 18 ) 5282 - 5287 2014.4
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Formation of Ligand-Assisted Complex of Two RNA Hairpin Loops
Changfeng Hong, Takahiro Otabe, Saki Matsumoto, Chikara Dohno, Asako Murata, Masaki Hagihara, and Kazuhiko Nakatani
Chemistry European Journal 2014.3
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Guanine-tethered antisense oligonucleotides as synthetic riboregulators.
Hagihara M
Methods in molecular biology (Clifton, N.J.) 1111 197 - 207 2014
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A Synthetic Riboswitch that Operates using a Rationally Designed Ligand-RNA Pair.
Chikara Dohno, Izumi Kohyama, Maki Kimura, Masaki Hagihara, Kazuhiko Nakatani
Angewandte Chemie (International ed. in English) 52 ( 38 ) 9976 - 9979 2013.9
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A Synthetic Riboswitch that Operates using a Rationally Designed Ligand-RNA Pair
Chikara Dohno, Izumi Kohyama, Maki Kimura, Masaki Hagihara, Kazuhiko Nakatani
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52 ( 38 ) 9976 - 9979 2013.9
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Activation of prokaryotic translation by antisense oligonucleotides binding to coding region of mRNA.
Gosuke Hayashi, Changfeng Hong, Masaki Hagihara, Kazuhiko Nakatani
Biochemical and biophysical research communications 429 ( 1-2 ) 105 - 110 2012.12
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Activation of prokaryotic translation by antisense oligonucleotides binding to coding region of mRNA
Gosuke Hayashi, Changfeng Hong, Masaki Hagihara, Kazuhiko Nakatani
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 429 ( 1-2 ) 105 - 110 2012.12
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Assembly of a Small DNA Rectangular Parallelepiped Block into Higher Order Nanostructures.
Hiroki Nakagawa, Mariko Toda, Hiroshi Atsumi, Masaki Hagihara, Mitsuko Hayashi-Nishino, Chikara Dohno, Kazuhiko Nakatani
Chemistry Letters 2012.11
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Assembly of a Small DNA Rectangular Parallelepiped Block into Higher Order Nanostructures
Hiroyuki Nakagawa, Mariko Toda, Hiroshi Atsumi, Masaki Hagihara, Mitsuko Hayashi-Nishino, Chikara Dohno, Kazuhiko Nakatani
CHEMISTRY LETTERS 41 ( 11 ) 1550 - 1552 2012.11
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Structure-activity studies on the fluorescent indicator in a displacement assay for the screening of small molecules binding to RNA.
Shiori Umemoto, Seongwang Im, Jinhua Zhang, Masaki Hagihara, Asako Murata, Yasue Harada, Takeo Fukuzumi, Takahiro Wazaki, Shin-ichi Sasaoka, Kazuhiko Nakatani
Chemistry (Weinheim an der Bergstrasse, Germany) 18 ( 32 ) 9999 - 10008 2012.8
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Structure-Activity Studies on the Fluorescent Indicator in a Displacement Assay for the Screening of Small Molecules Binding to RNA
Shiori Umemoto, Seongwang Im, Jinhua Zhang, Masaki Hagihara, Asako Murata, Yasue Harada, Takeo Fukuzumi, Takahiro Wazaki, Shin-ichi Sasaoka, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL 18 ( 32 ) 9999 - 10008 2012.8
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A small molecule regulates hairpin structures in d(CGG) trinucleotide repeats.
Masaki Hagihara, Hanping He, Maki Kimura, Kazuhiko Nakatani
Bioorganic & medicinal chemistry letters 22 ( 5 ) 2000 - 2003 2012.3
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A small molecule regulates hairpin structures in d(CGG) trinucleotide repeats
Masaki Hagihara, Hanping He, Maki Kimura, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22 ( 5 ) 2000 - 2003 2012.3
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Small molecule modulates hairpin structures in CAG trinucleotide repeats.
Masaki Hagihara, Hanping He, Kazuhiko Nakatani
Chembiochem : a European journal of chemical biology 12 ( 11 ) 1686 - 1689 2011.7
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Small Molecule Modulates Hairpin Structures in CAG Trinucleotide Repeats
Masaki Hagihara, Hanping He, Kazuhiko Nakatani
CHEMBIOCHEM 12 ( 11 ) 1686 - 1689 2011.7
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Ligand-assisted complex formation of two DNA hairpin loops.
Changfeng Hong, Masaki Hagihara, Kazuhiko Nakatani
Angewandte Chemie (International ed. in English) 50 ( 19 ) 4390 - 4393 2011.5
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Ligand-Assisted Complex Formation of Two DNA Hairpin Loops
Changfeng Hong, Masaki Hagihara, Kazuhiko Nakatani
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50 ( 19 ) 4390 - 4393 2011
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Antisense-induced guanine quadruplexes inhibit reverse transcription by HIV-1 reverse transcriptase.
Masaki Hagihara, Lisa Yamauchi, Akiko Seo, Keisuke Yoneda, Mayo Senda, Kazuhiko Nakatani
Journal of the American Chemical Society 132 ( 32 ) 11171 - 11178 2010.8
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Antisense-Induced Guanine Quadruplexes Inhibit Reverse Transcription by HIV-1 Reverse Transcriptase
Masaki Hagihara, Lisa Yamauchi, Akiko Seo, Keisuke Yoneda, Mayo Senda, Kazuhiko Nakatani
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132 ( 32 ) 11171 - 11178 2010.8
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A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA.
Masaki Hagihara, Keisuke Yoneda, Hiroaki Yabuuchi, Yasushi Okuno, Kazuhiko Nakatani
Bioorganic & medicinal chemistry letters 20 ( 7 ) 2350 - 2353 2010.4
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A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA
Masaki Hagihara, Keisuke Yoneda, Hiroaki Yabuuchi, Yasushi Okuno, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20 ( 7 ) 2350 - 2353 2010.4
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A small molecule affecting the replication of trinucleotide repeat d(GAA)n.
Hanping He, Masaki Hagihara, Kazuhiko Nakatani
Chemistry (Weinheim an der Bergstrasse, Germany) 15 ( 40 ) 10641 - 10648 2009.10
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RNA aptamers that reversibly bind photoresponsive azobenzene-containing peptides.
Gosuke Hayashi, Masaki Hagihara, Kazuhiko Nakatani
Chemistry (Weinheim an der Bergstrasse, Germany) 15 ( 2 ) 424 - 432 2009.6
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Secondary-structure-inducible ligand fluorescence coupled with PCR.
Fumie Takei, Masako Igarashi, Masaki Hagihara, Yoshimi Oka, Yoshihiro Soya, Kazuhiko Nakatani
Angewandte Chemie (International ed. in English) 48 ( 42 ) 7822 - 7824 2009.6
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Unstable tandem repeats in promoters confer transcriptional evolvability.
Marcelo D Vinces, Matthieu Legendre, Marina Caldara, Masaki Hagihara, Kevin J Verstrepen
Science (New York, N.Y.) 324 ( 5931 ) 1213 - 1216 2009.5
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Unstable Tandem Repeats in Promoters Confer Transcriptional Evolvability
Marcelo D. Vinces, Matthieu Legendre, Marina Caldara, Masaki Hagihara, Kevin J. Verstrepen
SCIENCE 324 ( 5931 ) 1213 - 1216 2009.5
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A Small Molecule Affecting the Replication of Trinucleotide Repeat d(GAA)(n)
Hanping He, Masaki Hagihara, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL 15 ( 40 ) 10641 - 10648 2009
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Secondary-Structure-Inducible Ligand Fluorescence Coupled with PCR
Fumie Takei, Masako Igarashi, Masaki Hagihara, Yoshimi Oka, Yoshihiro Soya, Kazuhiko Nakatani
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 48 ( 42 ) 7822 - 7824 2009
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RNA Aptamers That Reversibly Bind Photoresponsive Azobenzene-Containing Peptides
Gosuke Hayashi, Masaki Hagihara, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL 15 ( 2 ) 424 - 432 2009
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Ligand binding to tandem G quadruplexes from human telomeric DNA.
Li-Ping Bai, Masaki Hagihara, Zhi-Hong Jiang, Kazuhiko Nakatani
Chembiochem : a European journal of chemical biology 9 ( 16 ) 2583 - 2587 2008.11
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Ligand Binding to Tandem G Quadruplexes from Human Telomeric DNA
Li-Ping Bai, Masaki Hagihara, Zhi-Hong Jiang, Kazuhiko Nakatani
CHEMBIOCHEM 9 ( 16 ) 2583 - 2587 2008.11
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DNA labeling by ligand inducible secondary structure.
Tao Peng, Hanping He, Masaki Hagihara, Kazuhiko Nakatani
Chembiochem : a European journal of chemical biology 9 ( 12 ) 1893 - 1897 2008.8
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DNA labeling by ligand inducible secondary structure
Tao Peng, Hanping He, Masaki Hagihara, Kazuhiko Nalkatani
CHEMBIOCHEM 9 ( 12 ) 1893 - 1897 2008.8
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Context-dependent fluorescence detection of a phosphorylated tyrosine residue by a ribonucleopeptide.
Tetsuya Hasegawa, Masaki Hagihara, Masatora Fukuda, Shun Nakano, Nobutaka Fujieda, Takashi Morii
Journal of the American Chemical Society 130 ( 27 ) 8804 - 8812 2008.7
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Context-dependent fluorescence detection of a phosphorylated tyrosine residue by a ribonucleopeptide
Tetsuya Hasegawa, Masaki Hagihara, Masatora Fukuda, Shun Nakano, Nobutaka Fujieda, Takashi Morii
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 130 ( 27 ) 8804 - 8812 2008.7
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Genotyping by allele-specific L-DNA-tagged PCR.
Gosuke Hayashi, Masaki Hagihara, Kazuhiko Nakatani
Journal of biotechnology 135 ( 2 ) 157 - 160 2008.6
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Genotyping by allele-specific L-DNA-tagged PCR
Gosuke Hayashi, Masaki Hagihara, Kazuhiko Nakatani
JOURNAL OF BIOTECHNOLOGY 135 ( 2 ) 157 - 160 2008.6
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Ligand-stabilized hairpin structures interfere with elongation of human telomere.
Masaki Hagihara, Yuki Goto, Kazuhiko Nakatani
Chembiochem : a European journal of chemical biology 9 ( 4 ) 510 - 513 2008.3
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Ligand-Stabilized Hairpin Structures Interfered with Elongation of Human Telomere
Masaki Hagihara, Yuki Goto, Kazuhiko Nakatani
ChemBioChem 2008, 9, 510-513 9 ( 4 ) 510 - 3 2008
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RNA aptamers that reversibly bind to photoresponsive peptide.
Hayashi G, Hagihara M, Nakatani K
Nucleic acids symposium series (2004) ( 52 ) 703 - 4 2008
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Photoregulation of a peptide-RNA interaction on a gold surface.
Gosuke Hayashi, Masaki Hagihara, Chikara Dohno, Kazuhiko Nakatani
Journal of the American Chemical Society 129 ( 28 ) 8678 - 8679 2007.7
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Photoregulation of a peptide-RNA interaction on a gold surface
Gosuke Hayashi, Masaki Hagihara, Chikara Dohno, Kazuhiko Nakatani
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129 ( 28 ) 8678 - + 2007.7
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Allele specific C-bulge probes with one unique fluorescent molecule discriminate the single nucleotide polymorphism in DNA.
Fumie Takei, Hitoshi Suda, Masaki Hagihara, Jinhua Zhang, Akio Kobori, Kazuhiko Nakatani
Chemistry (Weinheim an der Bergstrasse, Germany) 13 ( 16 ) 4452 - 4457 2007.6
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Stepwise functionalization of ribonucleopeptides: optimization of the response of fluorescent ribonucleopeptide sensors for ATP.
Tetsuya Hasegawa, Masaki Hagihara, Masatora Fukuda, Takashi Morii
Nucleosides, nucleotides & nucleic acids 26 ( 10-12 ) 1277 - 1281 2007.6
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Small-molecule binding to the nonquadruplex form of the human telomeric sequence.
Yuki Goto, Shinya Hagihara, Masaki Hagihara, Kazuhiko Nakatani
Chembiochem : a European journal of chemical biology 8 ( 7 ) 723 - 726 2007.5
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Small-molecule binding to the nonquadruplex form of the human telomeric sequence
Yuki Goto, Shinya Hagihara, Masaki Hagihara, Kazuhiko Nakatani
CHEMBIOCHEM 8 ( 7 ) 723 - 726 2007.5
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Detection of L-DNA-tagged PCR products by surface plasmon resonance imaging.
Gosuke Hayashi, Masaki Hagihara, Akio Kobori, Kazuhiko Nakatani
Chembiochem : a European journal of chemical biology 8 ( 2 ) 169 - 171 2007.1
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Detection of L-DNA-tagged PCR products by surface plasmon resonance imaging
Gosuke Hayashi, Masaki Hagihara, Akio Kobori, Kazuhiko Nakatani
CHEMBIOCHEM 8 ( 2 ) 169 - 171 2007.1
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Allele specific C-bulge probes with one unique fluorescent molecule discriminate the single nucleotide polymorphism in DNA
Fumie Takei, Hitoshi Suda, Masaki Hagihara, Jinhua Zhang, Akio Kobori, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL 13 ( 16 ) 4452 - 4457 2007
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Stepwise functionalization of ribonucleopeptides: Optimization of the response of fluorescent ribonucleopeptide sensors for ATP
Tetsuya Hasegawa, Masaki Hagihara, Masatora Fukuda, Takashi Morii
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 26 ( 10-12 ) 1277 - 1281 2007
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Reversible regulation of binding between a photoresponsive peptide and its RNA aptamer.
Hayashi G, Hagihara M, Dohno C, Nakatani K
Nucleic acids symposium series (2004) ( 51 ) 93 - 4 2007
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A modular strategy for tailoring fluorescent biosensors from ribonucleopeptide complexes.
Masaki Hagihara, Masatora Fukuda, Tetsuya Hasegawa, Takashi Morii
Journal of the American Chemical Society 128 ( 39 ) 12932 - 12940 2006.10
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A modular strategy for tailoring fluorescent biosensors from ribonucleopeptide complexes
Masaki Hagihara, Masatora Fukuda, Tetsuya Hasegawa, Takashi Morii
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 128 ( 39 ) 12932 - 12940 2006.10
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Inhibition of DNA replication by a d(CAG) repeat binding ligand.
Hagihara M, Nakatani K
Nucleic acids symposium series (2004) ( 50 ) 147 - 8 2006
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Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats.
Kazuhiko Nakatani, Shinya Hagihara, Yuki Goto, Akio Kobori, Masaki Hagihara, Gosuke Hayashi, Motoki Kyo, Makoto Nomura, Masaki Mishima, Chojiro Kojima
Nature chemical biology 1 ( 1 ) 39 - 43 2005.6
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Small-molecule ligand induces nucleotide flipping in (CAG)(n) trinucleotide repeats
K Nakatani, S Hagihara, Y Goto, A Kobori, M Hagihara, G Hayashi, M Kyo, M Nomura, M Mishima, C Kojima
NATURE CHEMICAL BIOLOGY 1 ( 1 ) 39 - 43 2005.6
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Stepwise molding of a highly selective ribonucleopeptide receptor.
Shin-ichi Sato, Masatora Fukuda, Masaki Hagihara, Yukiko Tanabe, Katsutoshi Ohkubo, Takashi Morii
Journal of the American Chemical Society 127 ( 1 ) 30 - 31 2005.1
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Stepwise molding of a highly selective ribonucleopeptide receptor
S Sato, M Fukuda, M Hagihara, Y Tanabe, K Ohkubo, T Morii
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 127 ( 1 ) 30 - 31 2005.1
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Application of L-DNA as a molecular tag.
Hayashi G, Hagihara M, Nakatani K
Nucleic acids symposium series (2004) ( 49 ) 261 - 2 2005
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Solution structure of a small-molecular ligand complexed with CAG trinucleotide repeat DNA.
Nakatani K, Hagihara S, Goto Y, Kobori A, Hagihara M, Hayashi G, Kyo M, Nomura M, Mishima M, Kojima C
Nucleic acids symposium series (2004) ( 49 ) 49 - 50 2005
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Solution structure of a small-molecular ligand complexed with CAG trinucleotide repeat DNA.
Kazuhiko Nakatani, Shinya Hagihara, Yuki Goto, Akio Kobori, Masaki Hagihara, Gosuke Hayashi, Motoki Kyo, Makoto Nomura, Masaki Mishima, Chojiro Kojima
Nucleic acids symposium series (2004) ( 49 ) 49 - 50 2005
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RNAペプチド複合体の段階的高機能化
福田将虎, 佐藤慎一, 萩原正規, 大久保捷敏, 森井孝
日本化学会第85春季年会，神奈川大学，2005.3.26-29 2005
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Ribonucleopeptides: functional RNA-peptide complexes.
Masaki Hagihara, Tetsuya Hasegawa, Shin-ichi Sato, Susumu Yoshikawa, Katsutoshi Ohkubo, Takashi Morii
Biopolymers 76 ( 1 ) 66 - 68 2004.6
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Ribonucleopeptides: Functional RNA-peptide complexes
M Hagihara, T Hasegawa, S Sato, S Yoshikawa, K Ohkubo, T Morii
BIOPOLYMERS 76 ( 1 ) 66 - 68 2004.4
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Ribonucleopeptide receptors
Masaki Hagihara, Tetsuya Hasegawa, Shin-ichi Sato, Susumu Yoshikawa, Katsutoshi Ohkubo, Takashi Morii
Peptide Revolution: Genomics, Proteomics & Therapeutics 556 - 558 2004
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Design of a ribonucleopeptide biosensor.
Hagihara M, Hirata A, Ohkubo K, Morii T
Nucleic acids research. Supplement (2001) ( 3 ) 193 - 4 2003
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Optimization of an ATP-binding ribonucleopeptide receptor.
Sato S, Hasegawa T, Hagihara M, Fukuda M, Ohkubo K, Morii T
Nucleic acids research. Supplement (2001) ( 3 ) 239 - 40 2003
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Optimization of an ATP-binding ribonucleopeptide receptor.
S. Sato, T. Hasegawa, M. Hagihara, M. Fukuda, K. Ohkubo, T. Morii
Nucleic acids research. Supplement (2001) ( 3 ) 239 - 240 2003
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Design of Functional Ribonucleopeptide Complexes
Masaki Hagihara, Shin-ichi Sato, Katsutoshi Ohkubo, Takashi Morii
The New Frontier of RNA Science，Kyoto 2003
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Chemical approaches untangling sequence-specific DNA binding by proteins.
Shin-ichi Sato, Masaki Hagihara, Kenji Sugimoto, Takashi Morii
Chemistry (Weinheim an der Bergstrasse, Germany) 8 ( 22 ) 5066 - 5071 2002.11
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Chemical approaches untangling sequence-specific DNA binding by proteins
S Sato, M Hagihara, K Sugimoto, T Morii
CHEMISTRY-A EUROPEAN JOURNAL 8 ( 22 ) 5066 - 5071 2002.11
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A general strategy to determine a target DNA sequence of a short peptide: application to a D-peptide.
Takashi Morii, Tomohisa Tanaka, Shin-ichi Sato, Masaki Hagihara, Yasunori Aizawa, Keisuke Makino
Journal of the American Chemical Society 2002.6
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In vitro selection of ATP-binding receptors using a ribonucleopeptide complex.
Takashi Morii, Masaki Hagihara, Shin-ichi Sato, Keisuke Makino
Journal of the American Chemical Society 124 ( 17 ) 4617 - 4622 2002.5
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In vitro selection of ATP-binding receptors using a ribonucleopeptide complex
T Morii, M Hagihara, SI Sato, K Makino
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 124 ( 17 ) 4617 - 4622 2002.5
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Structure-based design of a leucine zipper protein with new DNA contacting region.
Takashi Morii, Shin-ichi Sato, Masaki Hagihara, Yasuo Mori, Keiji Imoto, Keisuke Makino
Biochemistry 41 ( 7 ) 2177 - 2183 2002.2
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Structure-based design of a leucine zipper protein with new DNA contacting region
Takashi Morii, Shin-Ichi Sato, Masaki Hagihara, Yasuo Mori, Keiji Imoto, Keisuke Makino
Biochemistry 41 ( 7 ) 2177 - 2183 2002.2
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A general strategy to determine a target DNA sequence of a short peptide: Application to a D-peptide
T Morii, T Tanaka, S Sato, M Hagihara, Y Aizawa, K Makino
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 124 ( 2 ) 180 - 181 2002.1
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A new strategy to determine the target DNA sequence of a short peptide.
Sato S, Honjyo H, Tsuji S, Hagihara M, Makino K, Morii T
Nucleic acids research. Supplement (2001) ( 2 ) 205 - 6 2002
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オリゴペプチド標的DNA配列の一般的決定法
佐藤慎一, 田中智久, 萩原正規, 相沢康則, 森井孝, 牧野圭祐
日本化学会第81春季年会，2F6-10，2002 2002
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RNA・ペプチド複合体（リボヌクレオペプチド）による分子認識
萩原正規, 森井孝, 牧野圭祐
日本化学会第81春季年会，2F6-12，2002 2002
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Recognition of small molecules by a ribonucleopeptide.
M. Hagihara, T. Morii, K. Makino
Nucleic Acids Res Suppl ( 1 ) 7 - 8 2001
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In vitro selection of RNA aptamers that respond to a small RNA-binding ligand
M. hagihara, T. Morii, K. Makino
環太平洋国際化学会議，Hawaii（米国） 2000
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Participation of oligomerization through C-terminal D domain region of Sp1 in DNA binding
K Matsushita, M Hagihara, Y Sugiura
BIOLOGICAL & PHARMACEUTICAL BULLETIN 21 ( 10 ) 1094 - 1097 1998.10
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Participation of oligomerization through C-terminal D domain region of Sp1 in DNA binding.
Keizo Matsushita, Masaki Hagihara, Yukio Sugiura
Biological & Pharmaceutical Bulletin 1998.6
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A novel zinc finger-based DNA cutter: biosynthetic design and highly selective DNA cleavage.
Makoto Nagaoka, Masaki Hagihara, Jun Kuwahara, Yukio Sugiura
Journal of the American Chemical Society 1994.6
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A NOVEL ZINC FINGER-BASED DNA CUTTER - BIOSYNTHETIC DESIGN AND HIGHLY SELECTIVE DNA CLEAVAGE
M NAGAOKA, M HAGIHARA, J KUWAHARA, Y SUGIURA
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 116 ( 9 ) 4085 - 4086 1994.5
Books
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Methods in Molecular Biology, Vol. 1111, P. 197-208
Masaki Hagihara（ Role： Contributor , Guanine-Tethered Antisense Oligonucleotides as Synthetic Riboregulators）
Springer 2014
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Chembiomolecular Science, At the Frontier of Chemistry and Biology, P. 59-67
Shiori Umemoto, Changfeng Hong, Jinhua Zhang, Takeo Fukuzumi, Asako Murata, Masaki Hagihara, Kazuhiko Nakatani（ Role： Contributor , Toward the Discovery of Small Molecules Affecting RNA Function）
Springer 2011
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Peptide Revolution: Genomics, Proteomics & Therapeutics. P. 556–558
Masaki Hagihara, Tetsuya Hasegawa, Shin-ichi Sato, Susumu Yoshikawa, Katsutoshi Ohkubo, Takashi Morii（ Role： Contributor）
American Peptide Society 2004
Review Papers
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Guanine-Tethered Antisense Oligonucleotides as Synthetic Riboregulators
Masaki Hagihara
Methods in Molecular Biology 2014.4
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Toward the Discovery of Small Molecules Affecting RNA Function
Shiori Umemoto, Changfeng Hong, Jinhua Zhang, Takeo Fukuzumi, Asako Murata, Masaki Hagihara, Kazuhiko Nakatani
Chembiomolecular Science, At the Frontier of Chemistry and Biology 2012.6
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Development of a Nanobiodevice based Ribonucleopeptide Complex
T. Hasegawa, M. Hagihara, S. Sato, K. Ohkubo, T. Morii, S. Yoshikawa
The 2nd International Symposium on Sustainable Energy System,Kyoto University Clock Tower Centennial Hall, Kyoto (Japan),2004.12.17-18 2004.12
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Tailoring receptors and sensors from an RNA-peptide assmebly
Y. Tanabe, M. Hagihara, S. Sato, K. Ohkubo, T. Morii
International symposium on Nano-organization and Function,Tokyo,2004.11.11-12 2004.11
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Design of sensing ribonucleopeptides for small ligands.
M. Hagihara, T. Hasegawa, Y. Tanabe, S. Sato, S. Yoshikawa, K. Ohkubo, T. Morii
Nucleic acids symposium series (2004) ( 48 ) 33 - 34 2004
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Recognition of Small Molecules by an RNA-peptide Complex
HAGIHARA Masaki, SATO Shin-ichi, MORII Takashi, MAKINO Keisuke
2002 425 - 426 2003.2
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Design of a ribonucleopeptide biosensor
Masaki Hagihara, Akiyoshi Hirata, Katsutoshi Ohkubo, Takashi Morii
the 30th Nucleic Acids Chemistry Symposium,Sapporo 2003
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Design of phosphotyrosine-specific ribonucleopeptide receptors
Tetsuya Hasegawa, Masaki Hagihara, Shin-ichi Sato, Takashi Morii, Katsutoshi Ohkubo, Susumu Yoshikawa
The 1st International Symposium on Sustainable Energy System,Kyoto University 21COE Establishment of COE on Sustainable Energy System,Kyoto 2003
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短鎖ペプチドによる認識DNA塩基配列の決定
佐藤慎一, 本庄弘一, 辻晋司, 萩原正規, 牧野圭祐, 森井孝
第29回核酸化学シンポジウム，2-P37，2002 2002
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RNA・ペプチド複合体による人工リセプター（リボヌクレオペプチドリセプター）の創製
萩原正規, 森井孝, 牧野圭祐
第74回日本生化学会大会，4P-012，2001 2001
Awards
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Young Investigators’ Awards
2007.04
Social Activities
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青森県立弘前南高等学校「南陵サイエンスセミナー」
2017.11.11
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弘前南高校ＳＳＨ事業「南陵サイエンスセミナー」
2017.11
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化学への招待 弘前大学一日体験化学教室
2017.08.07
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青森県立弘前南高等学校「南陵サイエンスセミナー」
2016.11.12
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弘前南高校ＳＳＨ事業「南陵サイエンスセミナー」
2016.11
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青森県立弘前南高等学校「南陵サイエンスセミナーIII」
2015.10.31
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青森県立弘前南高等学校「南陵サイエンスセミナーIⅡ」
2015.10
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北海道札幌新川高等学校 上級学校セミナー２０１４
2014.11.05
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北海道札幌新川高等学校 上級学校セミナー２０１４
2014.11
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青森県立弘前南高等学校「南陵サイエンスセミナーII」
2014.10.04
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青森県立弘前南高等学校「南陵サイエンスセミナーⅡ」
2014.10
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青森県立八戸北高等学校「青森サイエンスキャンプ」
2014.09.06 - 2014.09.07
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青森県立八戸北高等学校「青森サイエンスキャンプ」
2014.09
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平成２６年度教員免許状更新講習会担当
2014.08
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平成２６年度弘前大学ドリーム講座
2014.07.25
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平成２６年度弘前大学ドリーム講座 三沢高等学校
2014.07
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青森県立弘前南高等学校「南陵サイエンスセミナーII」
2013.10.05 - 2013.10.06
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青森県立弘前南高等学校「南陵サイエンスセミナーⅡ」
2013.10
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青森県立八戸北高等学校「青森サイエンスキャンプ」
2013.09.07 - 2013.09.08
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青森県立八戸北高等学校「青森サイエンスキャンプ」
2013.09
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青森県立八戸北高等学校「青森サイエンスキャンプ」
2012.09.08 - 2012.09.09
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青森県立八戸北高等学校「青森サイエンスキャンプ」
2012.09