Updated on 2022/12/09

写真a

 
TAKAYASU SHINOBU
 
Affiliation
Graduate School of Medicine Medical Science Course Endocorinology and Metabolism

Degree

  • Docter(Medical)

Research Areas

  • Life Science / Metabolism and endocrinology

  • Life Science / Molecular biology

Professional Memberships

  • 日本内分泌学会

Papers

  • Eosinophil counts can be a predictive marker of immune checkpoint inhibitor-induced secondary adrenal insufficiency: a retrospective cohort study.

    Takayasu S, Mizushiri S, Watanuki Y, Yamagata S, Usutani M, Nakada Y, Asari Y, Murasawa S, Kageyama K, Daimon M

    Scientific reports   12 ( 1 )   1294   2022.1

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  • Diabetic ketoacidosis shortly after COVID-19 vaccination in a non-small-cell lung cancer patient receiving combination of PD-1 and CTLA-4 inhibitors: A case report.

    Makiguchi T, Fukushima T, Tanaka H, Taima K, Takayasu S, Tasaka S

    Thoracic cancer   2022.2

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  • Identification of a homozygous c.1039C>T (p.R347C) variant in CYP17A1 in a 67-year-old female patient with partial 17α-hydroxylase/17,20-lyase deficiency

    Yamagata S, Kageyama K, Usui T, Saito K, Takayasu S, Usutani M, Terui K, Daimon M.

    Endocrine Journal   69 ( 2 )   115 - 120   2022.2

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  • CYP17A1遺伝子p.R347Cホモ接合体変異による17α水酸化酵素欠損症 高齢で診断された一例

    山形 聡, 臼井 健, 齋藤 洸平, 高安 忍, 臼谷 真理, 照井 健, 蔭山 和則, 大門 眞

    日本内分泌学会雑誌   97 ( 1 )   225 - 225   2021.4

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  • Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells

    Hagiwara R, Kageyama K, Niioka K, Takayasu S, Tasso M, Daimon M

    Peptides   2021.2

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  • Differential effects of β-arrestin1 and β-arrestin2 on somatostatin receptors in murine AtT-20 corticotroph tumor cells

    Kageyama K, Hagiwara R, Niioka K, Takayasu S, Daimon M

    Endocrine Journal   2021.2

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  • Differential effects of β-arrestin1 and β-arrestin2 on somatostatin receptors in murine AtT-20 corticotroph tumor cells

    Kageyama Kazunori, Hagiwara Rie, Niioka Kanako, Takayasu Shinobu, Daimon Makoto

    Endocrine Journal   68 ( 2 )   163 - 170   2021

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  • Identification of a homozygous c.1039C>T (p.R347C) variant in <i>CYP17A1</i> in a 67-year-old female patient with partial 17α-hydroxylase/17,20-lyase deficiency

    Yamagata Satoshi, Kageyama Kazunori, Usui Takeshi, Saito Kohei, Takayasu Shinobu, Usutani Mari, Terui Ken, Daimon Makoto

    Endocrine Journal   advpub ( 0 )   115 - 120   2021

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  • The activation of G protein-coupled receptor 30 increases pro-opiomelanocortin gene expression through cAMP/PKA/NR4A pathway in mouse pituitary corticotroph AtT-20 cells.

    Shinobu Takayasu, Mari Usutani, Koshi Makita, Makoto Daimon

    Neuroscience letters   739   135468 - 135468   2020.11

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  • Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells.

    Rie Hagiwara, Kazunori Kageyama, Kanako Niioka, Shinobu Takayasu, Mizuki Tasso, Makoto Daimon

    Peptides   136   170441 - 170441   2020.11

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  • The activation of G protein-coupled receptor 30 increases pro-opiomelanocortin gene expression through cAMP/PKA/NR4A pathway in mouse pituitary corticotroph AtT-20 cells

    Takayasu S, Usutani M, Makita K, Daimon M

    Neuroscience letters   2020.11

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  • Secondary oxalosis induced by xylitol concurrent with lithium-induced nephrogenic diabetes insipidus: a case report.

    Shinobu Takayasu, Aya Kamba, Kazutaka Yoshida, Ken Terui, Yutaka Watanuki, Noriko Ishigame, Satoru Mizushiri, Tetsu Tomita, Kazuhiko Nakamura, Norio Yasui-Furukori, Makoto Daimon

    BMC nephrology   21 ( 1 )   157 - 157   2020.5

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  • Secondary oxalosis induced by xylitol concurrent with lithium-induced nephrogenic diabetes insipidus: a case report

    Takayasu S, Kamba A, Yoshida K, Terui K, Watanuki Y, Ishigame N, Mizushiri S, Tomita T, Nakamura K, Yasui-Furukori N, Daimon M

    BMC nephrology   2020.5

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  • Association between higher urinary normetanephrine and insulin resistance in a Japanese population

    Murabayashi M, Daimon M, Murakami H, Fujita T, Sato E, Tanabe J, Matsuhashi Y, Takayasu S, Yanagimachi M, Terui K, Kageyama K, Tokuda I, Sawada K, Ihara K.

    PLOS ONE   2020.2

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  • Association between higher urinary normetanephrine and insulin resistance in a Japanese population.

    Masaya Murabayashi, Makoto Daimon, Hiroshi Murakami, Tomoyuki Fujita, Eri Sato, Jutaro Tanabe, Yuki Matsuhashi, Shinobu Takayasu, Miyuki Yanagimachi, Ken Terui, Kazunori Kageyama, Itoyo Tokuda, Kaori Sawada, Kazushige Ihara

    PloS one   15 ( 2 )   e0228787   2020

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  • Presence of aberrant adrenocorticotropic hormone precursors in two cases of McCune–Albright syndrome

    Takayasu Shinobu, Makita Koshi, Kageyama Kazunori, Okawa Yuta, Oki Yutaka, Yamagata Satoshi, Asari Yuko, Terui Ken, Daimon Makoto

    Endocrine Journal   67 ( 3 )   353 - 359   2020

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  • Progression of Hypopituitarism and Hypothyroidism after Treatment with Pembrolizumab in a Patient with Adrenal Metastasis from Non-small-cell Lung Cancer

    Yamagata Satoshi, Kageyama Kazunori, Takayasu Shinobu, Asari Yuko, Makita Koshi, Terui Ken, Daimon Makoto

    Internal Medicine   58 ( 24 )   3557 - 3562   2019.12

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  • Presence of aberrant adrenocorticotropic hormone precursors in two cases of McCune-Albright syndrome

    Takayasu S, Makita K, Kageyama K, Okawa Y, Oki Y, Yamagata S, Asari Y, Terui K, Daimon M

    Endocrine Journal   2019.12

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  • Progression of Hypopituitarism and Hypothyroidism after Treatment with Pembrolizumab in a Patient with Adrenal Metastasis from Non-small-cell Lung Cancer

    Yamagata S, Kageyama K, Takayasu S, Asari Y, Makita K, Terui K, Daimon M

    Internal medicine   2019.12

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  • O-linked β-N-acetylglucosamine transferase is involved in pro-opiomelanocortin gene expression in mouse pituitary corticotroph AtT-20 cells.

    Koshi Makita, Shinobu Takayasu, Mari Usutani, Yuki Nakada-Nakayama, Kazunori Kageyama, Akira Sugawara, Makoto Daimon

    Neuroscience letters   711   134407 - 134407   2019.10

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  • O-linked β-N-acetylglucosamine transferase is involved in pro-opiomelanocortin gene expression in mouse pituitary corticotroph AtT-20 cells

    Makita K, Takayasu S, Usutani M, Nakada-Nakayama Y, Kageyama K, Sugawara A, Daimon M

    Neuroscience letters   2019.10

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  • Evaluation of growth hormone-releasing peptide-2 for diagnosis of thyrotropin-producing pituitary adenomas

    Kageyama K, Sakihara S, Kameda W, Sugiyama A, Takayasu S, Terui K, Daimon M

    Endocrine journal   2018.10

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  • Evaluation of growth hormone-releasing peptide-2 for diagnosis of thyrotropin-producing pituitary adenomas

    Kageyama Kazunori, Sakihara Satoru, Kameda Wataru, Sugiyama Aya, Takayasu Shinobu, Terui Ken, Daimon Makoto

    Endocrine Journal   65 ( 10 )   1049 - 1054   2018

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  • Dominance of the hypothalamus-pituitary-adrenal axis over the renin-angiotensin-aldosterone system is a risk factor for decreased insulin secretion.

    Makoto Daimon, Aya Kamba, Hiroshi Murakami, Satoru Mizushiri, Sho Osonoi, Kota Matsuki, Eri Sato, Jutaro Tanabe, Shinobu Takayasu, Yuki Matsuhashi, Miyuki Yanagimachi, Ken Terui, Kazunori Kageyama, Itoyo Tokuda, Shizuka Kurauchi, Shigeyuki Nakaji

    Scientific reports   7 ( 1 )   11360 - 11360   2017.9

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  • Inhibitory effects of a selective Jak2 inhibitor on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT20 cells.

    Yuko Asari, Kazunori Kageyama, Yuki Nakada, Mizuki Tasso, Shinobu Takayasu, Kanako Niioka, Noriko Ishigame, Makoto Daimon

    OncoTargets and therapy   10   4329 - 4338   2017.9

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  • Dominance of the hypothalamus-pituitary-adrenal axis over the renin-angiotensin-aldosterone system is a risk factor for decreased insulin secretion.

    Makoto Daimon, Aya Kamba, Hiroshi Murakami, Satoru Mizushiri, Sho Osonoi, Kota Matsuki, Eri Sato, Jutaro Tanabe, Shinobu Takayasu, Yuki Matsuhashi, Miyuki Yanagimachi, Ken Terui, Kazunori Kageyama, Itoyo Tokuda, Shizuka Kurauchi, Shigeyuki Nakaji

    Scientific reports   7 ( 1 )   11360 - 11360   2017.9

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  • Association between serum prolactin levels and insulin resistance in non-diabetic men.

    Makoto Daimon, Aya Kamba, Hiroshi Murakami, Satoru Mizushiri, Sho Osonoi, Masato Yamaichi, Kota Matsuki, Eri Sato, Jutaro Tanabe, Shinobu Takayasu, Yuki Matsuhashi, Miyuki Yanagimachi, Ken Terui, Kazunori Kageyama, Itoyo Tokuda, Ippei Takahashi, Shigeyuki Nakaji

    PloS one   12 ( 4 )   e0175204 - e0175204   2017.4

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  • Acute mesenteric ischemia and hepatic infarction after treatment of ectopic Cushing's syndrome.

    Shinobu Takayasu, Shingo Murasawa, Satoshi Yamagata, Kazunori Kageyama, Takeshi Nigawara, Yutaka Watanuki, Daisuke Kimura, Takao Tsushima, Yoshiyuki Sakamoto, Kenichi Hakamada, Ken Terui, Makoto Daimon

    Endocrinology, diabetes & metabolism case reports   2017   2017.2

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  • Acute mesenteric ischemia and hepatic infarction after treatment of ectopic Cushing's syndrome.

    Shinobu Takayasu, Shingo Murasawa, Satoshi Yamagata, Kazunori Kageyama, Takeshi Nigawara, Yutaka Watanuki, Daisuke Kimura, Takao Tsushima, Yoshiyuki Sakamoto, Kenichi Hakamada, Ken Terui, Makoto Daimon

    Endocrinology, diabetes & metabolism case reports   2017   2017

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  • Association between serum prolactin levels and insulin resistance in non-diabetic men.

    Makoto Daimon, Aya Kamba, Hiroshi Murakami, Satoru Mizushiri, Sho Osonoi, Masato Yamaichi, Kota Matsuki, Eri Sato, Jutaro Tanabe, Shinobu Takayasu, Yuki Matsuhashi, Miyuki Yanagimachi, Ken Terui, Kazunori Kageyama, Itoyo Tokuda, Ippei Takahashi, Shigeyuki Nakaji

    PloS one   12 ( 4 )   e0175204   2017

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  • Inhibitory effects of a selective Jak2 inhibitor on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT20 cells.

    Yuko Asari, Kazunori Kageyama, Yuki Nakada, Mizuki Tasso, Shinobu Takayasu, Kanako Niioka, Noriko Ishigame, Makoto Daimon

    OncoTargets and therapy   10   4329 - 4338   2017

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  • Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population.

    Kamba A, Daimon M, Murakami H, Otaka H, Matsuki K, Sato E, Tanabe J, Takayasu S, Matsuhashi Y, Yanagimachi M, Terui K, Kageyama K, Tokuda I, Takahashi I, Nakaji S

    PLOS ONE   2016.11

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  • Regulation of the expression of corticotropin-releasing factor gene by pyroglutamylated RFamide peptide in rat hypothalamic 4B cells.

    Ishigame N, Kageyama K, Takayasu S, Furumai K, Nakada Y, Daimon M

    Endocrine journal   2016.10

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  • Adipsic hypernatremia without hypothalamic lesions accompanied by autoantibodies to subfornical organ.

    Takeshi Y Hiyama, Akari N Utsunomiya, Masahito Matsumoto, Akihiro Fujikawa, Chia-Hao Lin, Keiichi Hara, Reiko Kagawa, Satoshi Okada, Masao Kobayashi, Mayumi Ishikawa, Makoto Anzo, Hideo Cho, Shinobu Takayasu, Takeshi Nigawara, Makoto Daimon, Tomohiko Sato, Kiminori Terui, Etsuro Ito, Masaharu Noda

    Brain pathology (Zurich, Switzerland)   27 ( 3 )   323 - 331   2016.8

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  • Adipsic Hypernatremia Without Hypothalamic Lesions Accompanied by Autoantibodies to Subfornical Organ.

    Hiyama TY, Utsunomiya AN, Matsumoto M, Fujikawa A, Lin CH, Hara K, Kagawa R, Okada S, Kobayashi M, Ishikawa M, Anzo M, Cho H, Takayasu S, Nigawara T, Daimon M, Sato T, Terui K, Ito E, Noda M

    Brain Pathology   2016.6

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  • Evaluation of the (1-24) adrenocorticotropin stimulation test for the diagnosis of primary aldosteronism.

    Terui K, Kageyama K, Nigawara T, Moriyama T, Sakihara S, Takayasu S, Tsushima Y, Watanki Y, Yamagata S, Sugiyama A, Murasawa S, Nakada Y, Suda T, Daimon M.

    Journal of the Renin-Angiotensin-Aldosterone System   2016.5

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  • Evaluation of the (1-24) adrenocorticotropin stimulation test for the diagnosis of primary aldosteronism

    Ken Terui, Kazunori Kageyama, Takeshi Nigawara, Takako Moriyama, Satoru Sakihara, Shinobu Takayasu, Yuko Tsushima, Yutaka Watanki, Satoshi Yamagata, Aya Sugiyama, Shingo Murasawa, Yuki Nakada, Toshihiro Suda, Makoto Daimon

    JRAAS - Journal of the Renin-Angiotensin-Aldosterone System   17 ( 1 )   1470320315625703   2016.2

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  • The Cables1 Gene in Glucocorticoid Regulation of Pituitary Corticotrope Growth and Cushing Disease.

    Audrey Roussel-Gervais, Catherine Couture, David Langlais, Shinobu Takayasu, Aurelio Balsalobre, Bo R Rueda, Lawrence R Zukerberg, Dominique Figarella-Branger, Thierry Brue, Jacques Drouin

    The Journal of clinical endocrinology and metabolism   101 ( 2 )   513 - 522   2016.2

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  • The Cables1 Gene in Glucocorticoid Regulation of Pituitary Corticotrope Growth and Cushing Disease.

    Audrey Roussel-Gervais, Catherine Couture, David Langlais, Shinobu Takayasu, Aurelio Balsalobre, Bo R Rueda, Lawrence R Zukerberg, Dominique Figarella-Branger, Thierry Brue, Jacques Drouin

    The Journal of clinical endocrinology and metabolism   101 ( 2 )   513 - 22   2016.2

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  • Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population.

    Aya Kamba, Makoto Daimon, Hiroshi Murakami, Hideyuki Otaka, Kota Matsuki, Eri Sato, Jutaro Tanabe, Shinobu Takayasu, Yuki Matsuhashi, Miyuki Yanagimachi, Ken Terui, Kazunori Kageyama, Itoyo Tokuda, Ippei Takahashi, Shigeyuki Nakaji

    PloS one   11 ( 11 )   e0166077   2016

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  • Regulation of the expression of corticotropin-releasing factor gene by pyroglutamylated RFamide peptide in rat hypothalamic 4B cells

    Ishigame Noriko, Kageyama Kazunori, Takayasu Shinobu, Furumai Kengo, Nakada Yuki, Daimon Makoto

    Endocrine Journal   63 ( 10 )   919 - 927   2016

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  • Inhibitory effects of trichostatin A on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT-20 cells.

    Yuki Nakada, Kazunori Kageyama, Aya Sugiyama, Rie Desaki, Shinobu Takayasu, Kanako Niioka, Shingo Murasawa, Noriko Ishigame, Yuko Asari, Yasumasa Iwasaki, Makoto Daimon

    Endocrine journal   62 ( 12 )   1083 - 1090   2015.12

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  • Inhibitory effects of trichostatin A on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT-20 cells

    Nakada Yuki, Kageyama Kazunori, Sugiyama Aya, Desaki Rie, Takayasu Shinobu, Niioka Kanako, Murasawa Shingo, Ishigame Noriko, Asari Yuko, Iwasaki Yasumasa, Daimon Makoto

    Endocrine Journal   62 ( 12 )   1083 - 1090   2015

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  • Mutations in NFKB2 and potential genetic heterogeneity in patients with DAVID syndrome, having variable endocrine and immune deficiencies.

    Thierry Brue, Marie-Hélène Quentien, Konstantin Khetchoumian, Marco Bensa, José-Mario Capo-Chichi, Brigitte Delemer, Aurelio Balsalobre, Christina Nassif, Dimitris T Papadimitriou, Anne Pagnier, Caroline Hasselmann, Lysanne Patry, Jeremy Schwartzentruber, Pierre-François Souchon, Shinobu Takayasu, Alain Enjalbert, Guy Van Vliet, Jacek Majewski, Jacques Drouin, Mark E Samuels

    BMC medical genetics   15   139 - 139   2014.12

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  • Ultraviolet B radiation-stimulated urocortin 1 is involved in tyrosinase-related protein 1 production in human melanoma HMV-II cells.

    Yutaka Watanuki, Kazunori Kageyama, Shinobu Takayasu, Yasushi Matsuzaki, Yasumasa Iwasaki, Makoto Daimon

    Peptides   61   93 - 97   2014.11

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  • Ultraviolet B radiation-stimulated urocortin 1 is involved in tyrosinase-related protein 1 production in human melanoma HMV-II cells.

    Yutaka Watanuki, Kazunori Kageyama, Shinobu Takayasu, Yasushi Matsuzaki, Yasumasa Iwasaki, Makoto Daimon

    Peptides   61   93 - 7   2014.11

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  • Mutations in NFKB2 and potential genetic heterogeneity in patients with DAVID syndrome, having variable endocrine and immune deficiencies.

    Thierry Brue, Marie-Hélène Quentien, Konstantin Khetchoumian, Marco Bensa, José-Mario Capo-Chichi, Brigitte Delemer, Aurelio Balsalobre, Christina Nassif, Dimitris T Papadimitriou, Anne Pagnier, Caroline Hasselmann, Lysanne Patry, Jeremy Schwartzentruber, Pierre-François Souchon, Shinobu Takayasu, Alain Enjalbert, Guy Van Vliet, Jacek Majewski, Jacques Drouin, Mark E Samuels

    BMC medical genetics   15   139 - 139   2014

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  • Involvement of Nurr-1/Nur77 in corticotropin-releasing factor/urocortin1-induced tyrosinase-related protein 1 gene transcription in human melanoma HMV-II cells.

    Yutaka Watanuki, Shinobu Takayasu, Kazunori Kageyama, Yasumasa Iwasaki, Satoru Sakihara, Ken Terui, Takeshi Nigawara, Toshihiro Suda

    Molecular and cellular endocrinology   370 ( 1-2 )   42 - 51   2013.5

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  • Involvement of Nurr-1/Nur77 in corticotropin-releasing factor/urocortin1-induced tyrosinase-related protein 1 gene transcription in human melanoma HMV-II cells.

    2. Y. Watanuki, S. Takayasu, K. Kageyama, Y. Iwasaki, S. Sakihara, K. Terui, T. Nigawara, T. Suda

    Molecular and Cellular Endocrinology   2013.5

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  • Unusual type of growth hormone-producing pituitary tumor in acromegaly.

    Satoshi Yamagata, Kazunori Kageyama, Satoru Sakihara, Shozo Yamada, Shinobu Takayasu, Shinji Chikazawa, Naoko Inoshita, Toshiaki Sano, Toshihiro Suda

    Endocrine pathology   23 ( 3 )   201 - 4   2012.9

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  • Reduced cellular cholesterol efflux and low plasma high-density lipoprotein cholesterol in a patient with type B Niemann-Pick disease because of a novel SMPD-1 mutation

    Naoki Tamasawa, Shinobu Takayasu, Hiroshi Murakami, Maki Yamashita, Kota Matsuki, Jutaro Tanabe, Hiroshi Murakami, Jun Matsui, Kei Satoh, Toshihiro Suda

    JOURNAL OF CLINICAL LIPIDOLOGY   6 ( 1 )   74 - 80   2012.2

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  • Ghrelin stimulates corticotropin-releasing factor and vasopressin gene expression in rat hypothalamic 4B cells.

    Kazunori Kageyama, Yukiko Kumata, Kanako Akimoto, Shinobu Takayasu, Naoki Tamasawa, Toshihiro Suda

    Stress (Amsterdam, Netherlands)   14 ( 5 )   520 - 9   2011.9

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  • Autoimmunity: acquired versus inherited pituitary deficiency - same difference?

    Jacques Drouin, Shinobu Takayasu

    Nature reviews. Endocrinology   7 ( 5 )   255 - 6   2011.5

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  • A Case of 57-year Old Woman with Disturbed Consciousness and Difficulty in Body Movement.

    Tamai Yoshiko, Nigawara Takeshi, Takayasu Shinobu, Yamagata Kazufumi, Nakamura Norio, Osawa Hiroshi

    Nihon Naika Gakkai Zasshi   100 ( 4 )   1089 - 1097   2011

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  • A case of adrenocortical oncocytoma occurring with aldosteronoma.

    Ken Terui, Satoru Sakihara, Kazunori Kageyama, Takeshi Nigawara, Shinobu Takayasu, Yuki Matsuhashi, Akihito Kon, Hayato Yamamoto, Chikara Ohyama, Hironobu Sasano, Toshihiro Suda

    The Journal of clinical endocrinology and metabolism   95 ( 8 )   3597 - 8   2010.8

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  • Altered pain perception in schizophrenia.

    Hiroshi Murakami, Naoki Tamasawa, Maki Yamashita, Shinobu Takayasu, Takeshi Nigawara, Jun Matsui, Toshihiro Suda

    Lancet (London, England)   375 ( 9717 )   864 - 864   2010.3

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  • Involvement of nuclear factor-kB and Nurr-1 in cytokine-induced transcription of proopiomelanocortin gene in AtT20 corticotroph cells.

    Shinobu Takayasu, Yasumasa Iwasaki, Takeshi Nigawara, Masato Asai, Masanori Yoshida, Kazunori Kageyama, Toshihiro Suda

    Neuroimmunomodulation   17 ( 2 )   88 - 96   2010

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  • Cytokines induce NF-κB, Nurr1 and corticotropin-releasing factor gene transcription in hypothalamic 4B cells.

    Kazunori Kageyama, Saeko Kagaya, Shinobu Takayasu, Komaki Hanada, Yasumasa Iwasaki, Toshihiro Suda

    Neuroimmunomodulation   17 ( 5 )   305 - 13   2010

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  • Evaluation of Plasma, Salivary, and Urinary Cortisol Levels for Diagnosis of Cushing’s Syndrome

    SAKIHARA Satoru, KAGEYAMA Kazunori, OKI Yutaka, DOI Masaru, IWASAKI Yasumasa, TAKAYASU Shinobu, MORIYAMA Takako, TERUI Ken, NIGAWARA Takeshi, HIRATA Yukio, HASHIMOTO Kozo, SUDA Toshihiro

    Endocrine Journal   57 ( 4 )   331 - 337   2010

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  • Endothelial Cyst of the Adrenal Gland Associated with Adrenocortical Adenoma: Preoperative Images Simulate Carcinoma

    Nigawara Takeshi, Sakihara Satoru, Kageyama Kazunori, Terui Ken, Takayasu Shinobu, Hatakeyama Shingo, Ohyama Chikara, Sasano Hironobu, Suda Toshihiro

    Internal Medicine   48 ( 4 )   235 - 240   2009

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  • Involvement of regulatory elements on corticotropin-releasing factor gene promoter in hypothalamic 4B cells

    K. Kageyama, K. Hanada, S. Takayasu, Y. Iwasaki, S. Sakihara, T. Nigawara, T. Suda

    JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION   31 ( 12 )   1079 - 1085   2008.12

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  • A growth hormone-secreting adenoma with incomplete nerve bundle formation.

    Hidetoshi Ikeda, Shinobu Takayasu

    Neuropathology : official journal of the Japanese Society of Neuropathology   28 ( 3 )   317 - 21   2008.6

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  • Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoid-activating enzyme (11beta-hydroxysteroid dehydrogenase type 1) gene.

    Yasumasa Iwasaki, Shinobu Takayasu, Mitsuru Nishiyama, Makoto Tsugita, Takafumi Taguchi, Masato Asai, Masanori Yoshida, Machiko Kambayashi, Kozo Hashimoto

    Molecular and cellular endocrinology   285 ( 1-2 )   10 - 8   2008.3

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  • A Male Case of Nonclassical 21-hydroxylase Deficiency First Manifested in His Sixties with Adrenocortical Incidentaloma

    NIGAWARA Takeshi, KAGEYAMA Kazunori, SAKIHARA Satoru, TAKAYASU Shinobu, KAWAHARA Masayuki, IMAI Atsushi, OHYAMA Chikara, USUI Takeshi, SASANO Hironobu, SUDA Toshihiro

    Endocrine Journal   55 ( 2 )   291 - 297   2008

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  • Diagnostic Usefulness of the Growth Hormone-Releasing Peptide-2 Test as a Substitute for the Insulin Tolerance Test in Hypopituitarism

    KAGEYAMA Kazunori, NIGAWARA Takeshi, SAKIHARA Satoru, TAKAYASU Shinobu, TERUI Ken, MORIYAMA Takako, SUDA Toshihiro

    Endocrine Journal   55 ( 4 )   777 - 783   2008

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  • A neuropeptide ligand of the g proteincoupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure, and is implicated in metabolic syndrome

    Takayasu, Shinobu, Ohuchi, Takashi, Sakurai, Takeshi, Iwasaki, Satoshi, Iguchi, Haruhisa, Yamanaka, Akihiro, Teranishi, Hitoshi, Williams, S. Clay, Kawasawa, Yuka, Ikeda, Yukio, Dohmaes, Naoshi, Suda, Toshihiro, Motoike, Toshiyuki, Yanagisawa, Masashi, Sakai, Juro

    JOURNAL OF HYPERTENSION   24 ( Suppl. 6 )   155 - 155   2006.12

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  • Gene analysis of the calcium channel 1 subunit and clinical studies for two patients with hypokalemic periodic paralysis

    K. Kageyama, K. Terui, S. Tsutaya, E. Matsuda, M. Shoji, S. Sakihara, T. Nigawara, S. Takayasu, T. Moriyama, M. Yasujima, T. Suda

    JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION   29 ( 10 )   928 - 933   2006.11

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  • Identification of a functional AP1 element in the rat vasopressin gene promoter.

    Masanori Yoshida, Yasumasa Iwasaki, Masato Asai, Shinobu Takayasu, Takafumi Taguchi, Keiichi Itoi, Kozo Hashimoto, Yutaka Oiso

    Endocrinology   147 ( 6 )   2850 - 63   2006.6

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  • A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.

    Takayasu S, Sakurai T, Iwasaki S, Teranishi H, Yamanaka A, Williams SC, Iguchi H, Kawasawa YI, Ikeda Y, Sakakibara I, Ohno K, Ioka RX, Murakami S, Dohmae N, Xie J, Suda T, Motoike T, Ohuchi T, Yanagisawa M, Sakai J

    Proceedings of the National Academy of Sciences of the United States of America   103 ( 19 )   7438 - 43   2006.5

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  • A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.

    Shinobu Takayasu, Takeshi Sakurai, Satoshi Iwasaki, Hitoshi Teranishi, Akihiro Yamanaka, S Clay Williams, Haruhisa Iguchi, Yuka Imamura Kawasawa, Yukio Ikeda, Iori Sakakibara, Kousaku Ohno, Ryoichi X Ioka, Saori Murakami, Naoshi Dohmae, Jian Xie, Toshihiro Suda, Toshiyuki Motoike, Takashi Ohuchi, Masashi Yanagisawa, Juro Sakai

    Proceedings of the National Academy of Sciences of the United States of America   103 ( 19 )   7438 - 43   2006.5

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  • SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.

    Haruhisa Iguchi, Yukio Ikeda, Masashi Okamura, Toshiya Tanaka, Yasuyo Urashima, Hiroto Ohguchi, Shinobu Takayasu, Noriaki Kojima, Satoshi Iwasaki, Riuko Ohashi, Shuying Jiang, Go Hasegawa, Ryoichi X Ioka, Kenta Magoori, Koichi Sumi, Takashi Maejima, Aoi Uchida, Makoto Naito, Timothy F Osborne, Masashi Yanagisawa, Tokuo T Yamamoto, Tatsuhiko Kodama, Juro Sakai

    The Journal of biological chemistry   280 ( 45 )   37669 - 80   2005.11

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  • Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues.

    Yukio Ikeda, Haruhisa Iguchi, Masanori Nakata, Ryoichi X Ioka, Toshiya Tanaka, Satoshi Iwasaki, Kenta Magoori, Shinobu Takayasu, Tokuo T Yamamoto, Tatsuhiko Kodama, Toshihiko Yada, Takeshi Sakurai, Masashi Yanagisawa, Juro Sakai

    Biochemical and biophysical research communications   333 ( 3 )   778 - 86   2005.8

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  • Usefulness of the Thyrotropin-Releasing Hormone Test in Pre-Clinical Acromegaly

    Kageyama Kazunori, Moriyama Takako, Sakihara Satoru, Takayasu Shinobu, Nigawara Takeshi, Suda Toshihiro

    The Tohoku Journal of Experimental Medicine   206 ( 4 )   291 - 297   2005

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  • A Case of Pseudoaldosteronism, Accompanied with Hypocalcemia and Exaggerated ACTH Response

    KAGEYAMA Kazunori, TAKAYASU Shinobu, MORIYAMA Takako, SAKIHARA Satoru, SUDA Toshihiro

    Endocrine Journal   51 ( 1 )   83 - 87   2004

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  • Hypoglycemia Associated with Big Insulin-Like Growth Factor II Produced during Development of Malignant Fibrous Histiocytoma

    KAGEYAMA Kazunori, MORIYAMA Takako, HIZUKA Naomi, SAKIHARA Satoru, TAKAYASU Shinobu, TAMASAWA Naoki, SUDA Toshihiro

    Endocrine Journal   50 ( 6 )   753 - 758   2003

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Books

  • レビューブック内科・外科2022-2023

    髙安 忍( Role: Supervisor (editorial))

    メディックメディア  2021 

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  • レビューブック内科・外科2020-2021

    髙安 忍( Role: Sole author)

    メディックメディア  2019.5 

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Review Papers

  • QBオンラインCBT内分泌解説

    髙安 忍

    QBオンラインCBT2021   2021.9

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  • QBオンラインCBT内分泌解説

    髙安 忍

    QBオンラインCBT   2020.9

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  • 【内分泌腺腫瘍(第2版)-基礎・臨床研究のアップデート-】間脳・下垂体腫瘍 間脳・下垂体腫瘍の病態生理と臨床像 ACTH産生腺腫(Cushing病)

    高安 忍, 蔭山 和則, 大門 眞

    日本臨床   78 ( 増刊4 内分泌腺腫瘍 )   123 - 130   2020.9

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  • 診断が困難であった甲状腺原発MALTリンパ腫の1例

    萩原 莉恵, 照井 健, 藤田 朋之, 山形 聡, 綿貫 裕, 高安 忍, 蔭山 和則, 高畑 武功, 西村 顕正, 大門 眞

    日本内分泌学会雑誌   96 ( 1 )   293 - 293   2020.8

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  • トラマドールにより視床下部性ACTH分泌低下症が顕性化した神経線維腫症1型の一例

    綿貫 裕, 竹内 祐貴, 藤田 朋之, 山形 聡, 高安 忍, 蔭山 和則, 大門 眞

    日本内分泌学会雑誌   96 ( 1 )   254 - 254   2020.8

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  • CYP17A1遺伝子p.R347Cホモ接合体変異による17α水酸化酵素欠損症 高齢で診断された一例

    山形 聡, 臼井 健, 齋藤 洸平, 高安 忍, 臼谷 真理, 照井 健, 蔭山 和則, 大門 眞

    日本内分泌学会雑誌   96 ( 1 )   267 - 267   2020.8

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  • A型胃炎による高ガストリン血症を合併したインスリノーマ例

    臼谷 真理, 高安 忍, 村林 公哉, 山形 聡, 照井 健, 蔭山 和則, 大門 眞

    日本内分泌学会雑誌   96 ( 1 )   332 - 332   2020.8

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  • O-linked β-N-acetylglucosamine transferaseは、グルココルチコイドと協調してACTH産生下垂体細胞におけるproopiomelanocortin転写を抑制する

    高安 忍, 牧田 興志, 蔭山 和則, 臼谷 真理, 中山 有紀, 菅原 明, 大門 眞

    日本内分泌学会雑誌   95 ( 4 )   1455 - 1455   2020.2

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  • 内分泌腺腫瘍(第2 版) 基礎・臨床研究のアップデート  III.間脳・下垂体腫瘍

    髙安 忍, 蔭山 和則, 大門 眞

    日本臨牀   78 ( 4 )   123 - 130   2020

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  • 高用量DEX抵抗性サブクリニカルクッシング病in vitroでの検証

    臼谷 真理, 高安 忍, 志智 大城, 福岡 秀規, 山田 正三, 山形 聡, 杉山 綾, 照井 健, 川嶋 詳子, 蔭山 和則, 高橋 裕, 大門 眞

    日本内分泌学会雑誌   95 ( 2 )   763 - 763   2019.10

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  • 褐色細胞腫を合併した成人先天性心疾患患者の2例

    小山石 隼, 佐藤 理子, 佐々木 都寛, 山本 洋平, 三浦 文武, 嶋田 淳, 北川 陽介, 大谷 勝記, 伊藤 悦朗, 高橋 徹, 米坂 勧, 高安 忍, 二川原 健, 加藤 哲子

    日本小児科学会雑誌   123 ( 10 )   1605 - 1605   2019.10

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  • エストラジオール製剤による高コルチゾール血症とCBGへの影響

    萩原 莉恵, 蔭山 和則, 佐藤 江里, 高安 忍, 田辺 壽太郎, 照井 健, 大門 眞

    日本内分泌学会雑誌   95 ( 2 )   799 - 799   2019.10

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  • SGLT2阻害薬が著効した尿崩症を伴う若年肥満糖尿病患者の一例

    山形 聡, 田辺 壽太郎, 高安 忍, 綿貫 裕, 村林 公哉, 大門 眞

    日本内分泌学会雑誌   95 ( 2 )   815 - 815   2019.10

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  • ACR TIRADSを用いた甲状腺腫瘍の質的評価と細胞診妥当性の検討

    綿貫 裕, 臼谷 真理, 萩原 莉恵, 山形 聡, 対馬 悠子, 高安 忍, 照井 健, 蔭山 和則, 大門 眞

    日本内分泌学会雑誌   95 ( 2 )   789 - 789   2019.10

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  • Calcitoninによる腎amyloidosisを呈した甲状腺髄様癌の一例

    照井 健, 高安 忍, 蔭山 和則, 大門 眞, 島田 美智子, 中村 典雄

    日本内分泌学会雑誌   95 ( 2 )   790 - 790   2019.10

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  • 異所性GHRH産生インスリノーマ術後に続発性無月経を呈したMEN1

    杉山 綾, 高安 忍, 藤田 朋之, 水尻 諭, 佐藤 江里, 田辺 寿太郎, 照井 健, 蔭山 和則, 片上 秀喜, 大門 眞

    日本内分泌学会雑誌   95 ( Suppl.Update )   103 - 104   2019.6

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  • 原発性アルドステロン症に於けるFlow Mediated Dilatationの臨床応用

    照井 健, 鷲田 啓資, 牧田 興志, 浅利 ゆう子, 杉山 綾, 村澤 真吾, 山形 聡, 綿貫 裕, 対馬 悠子, 高安 忍, 蔭山 和則, 大門 眞

    日本内分泌学会雑誌   95 ( 1 )   470 - 470   2019.4

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  • 低用量に連続した高用量ACTH試験を用いた副腎皮質機能評価についての検討(第2報)

    高安 忍, 山形 聡, 臼谷 真理, 牧田 興志, 浅利 ゆう子, 杉山 綾, 村澤 真吾, 綿貫 裕, 対馬 悠子, 照井 健, 蔭山 和則, 大門 眞

    日本内分泌学会雑誌   95 ( 1 )   375 - 375   2019.4

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  • 原因不明の高インスリン血症を伴うnon-islet cell tumor hypoglycemia(NICTH)の一例

    山形 聡, 高安 忍, 村澤 真吾, 中山 弘文, 臼谷 真理, 村林 公哉, 杉山 綾, 照井 健, 大門 眞

    日本内分泌学会雑誌   95 ( 1 )   467 - 467   2019.4

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  • ECLIA法を用いた続発性副腎不全症診断についての検討

    臼谷 真理, 高安 忍, 牧田 興志, 浅利 ゆう子, 杉山 綾, 村澤 真吾, 山形 聡, 綿貫 裕, 対馬 悠子, 照井 健, 蔭山 和則, 大門 眞

    日本内分泌学会雑誌   95 ( 1 )   503 - 503   2019.4

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  • Dominance of Pituitary-Adrenal Axis over the Renin-Angiotensin-Aldosterone System Is a Risk Factor for a Decreased Insulin Secretion

    Makoto Daimon, Aya Kamba, Hiroshi Murakami, Satoru Mizushiri, Sho Osonoi, Masato Yamaichi, Kota Matsuki, Hideyuki Otaka, Eri Sato, Jutaro Tanabe, Shinobu Takayasu, Yuki Matsuhashi, Miyuki Yanagimachi, Ken Terui, Kazunori Kageyama, Ippei Takahashi, Shigeyuki Nakaji

    DIABETES   66   A651 - A651   2017.6

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    Web of Science

  • Ultraviolet Radiation B Stimulates Urocortin 1 Gene Expression and Tyrosinase-Related Protein 1 Protein Levels in Human Melanoma Hmv-II Cells

    Yutaka Watanuki, Shinobu Takayasu, Kazunori Kageyama, Makoto Daimon

    ENDOCRINE REVIEWS   35 ( 3 )   2014.6

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    Web of Science

  • A Role for Mediator in Pomc Transcriptional Activation By RNA Polymerase II

    Shinobu Takayasu, Jacques Drouin, Aurelio Balsalobre

    ENDOCRINE REVIEWS   35 ( 3 )   2014.6

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  • The suppressive effect of glucocorticoid on ACTH response to GHRP2

    Satoru Sakihara, Kazunori Kageyama, Shinobu Takayasu, Takako Moriyama, Ken Terui, Takeshi Nigawara, Toshihiro Suda

    ENDOCRINE JOURNAL   57   S528 - S528   2010.3

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    Web of Science

  • A case of SRY-positive, 46,XX/45,X/47,XXX DSD identified in the eighth decade of life

    Takeshi Nigawara, Maki Yamashita, Shinobu Takayasu, Hiroshi Murakami, Toshihiro Suda

    ENDOCRINE JOURNAL   57   S599 - S599   2010.3

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:JAPAN ENDOCRINE SOC   Kind of work:Joint Work  

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  • Orphan receptors Nurr-1/Nur77 are involvement in corticotropin-releasing hormone and urocortin induction of tyrosinase-related protein type 1 in human melanocytes

    Shinobu Takayasu, Yasumasa Iwasaki, Kazunori Kageyama, Toshihiro Suda

    ENDOCRINE JOURNAL   57   S442 - S443   2010.3

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:JAPAN ENDOCRINE SOC   Kind of work:Joint Work  

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  • Reduced choleserol efflux may be the cause of reduced plasma HDL-C levels in a patient with sphingomyelinase deficiency

    K. Matsuki, N. Tamasawa, S. Takayasu, J. Tanabe, H. Murakami, J. Matsui, T. Suda

    ATHEROSCLEROSIS SUPPLEMENTS   7 ( 3 )   542 - 543   2006.6

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Awards

  • 日本神経内分泌学会第3回若手研究奨励賞

    2003.09

Social Activities

  • がんチーム医療レポート がん免疫療法の現場から 弘前大学医学部附属病院 チーム医療により多職種で臨むirAE管理

    2020.10.15