論文 - 坂元 君年
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Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum.
Hironari Shimizu, Arihiro Osanai, Kimitoshi Sakamoto, Daniel Ken Inaoka, Tomoo Shiba, Shigeharu Harada, Kiyoshi Kita
Journal of biochemistry 151 ( 6 ) 589 - 592 2012年06月
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Age-related changes in the activities of respiratory chain complexes and mitochondrial morphology in Drosophila.
Yukiko Oda, Ryoko Yui, Kimitoshi Sakamoto, Kiyoshi Kita, Etsuko T Matsuura
Mitochondrion 12 ( 2 ) 345 - 351 2012年03月
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Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp. FKI-3389
Mihoko Mori, Hiromi Morimoto, Yong-Pil Kim, Hideaki Ui, Kenichi Nonaka, Rokuro Masuma, Kimitoshi Sakamoto, Kiyoshi Kita, Hiroshi Tomoda, Kazuro Shiomi, Satoshi Omura
Tetrahedron 67 ( 35 ) 6582 - 6586 2011年09月
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Differential Kinetics Activities of Glycerol Kinase among African Trypanosome Species: Phylogenetic and Therapeutic Implications
Mitsuko Ohashi-Suzuki, Yoshisada Yabu, Shigeru Ohshima, Kosuke Nakamura, Yasutoshi Kido, Kimitoshi Sakamoto, Kiyoshi Kita, Nobuo Ohta, Takashi Suzuki
Journal of Veterinary Medical Science 73 ( 5 ) 615 - 621 2011年05月
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Differential kinetic activities of glycerol kinase among African trypanosome species: phylogenetic and therapeutic implications.
Ohashi-Suzuki M, Yabu Y, Ohshima S, Nakamura K, Kido Y, Sakamoto K, Kita K, Ohta N, Suzuki T
The Journal of veterinary medical science 73 ( 5 ) 615 - 621 2011年05月
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Trypanosome alternative oxidase, a potential therapeutic target for sleeping sickness, is conserved among Trypanosoma brucei subspecies
Kosuke Nakamura, Sunao Fujioka, Shinya Fukumoto, Noboru Inoue, Kimitoshi Sakamoto, Haruyuki Hirata, Yasutoshi Kido, Yoshisada Yabu, Takashi Suzuki, Yo-ichi Watanabe, Hiroyuki Saimoto, Hiroshi Akiyama, Kiyoshi Kita
Parasitology International 59 ( 4 ) 560 - 564 2010年12月
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Purification and kinetic characterization of recombinant alternative oxidase from Trypanosoma brucei brucei
Yasutoshi Kido, Kimitoshi Sakamoto, Kosuke Nakamura, Michiyo Harada, Takashi Suzuki, Yoshisada Yabu,Hiroyuki Saimoto, Fumiyuki Yamakura, Daijiro Ohmori, Anthony Moore, Shigeharu Harada, Kiyoshi Kita
Biochimica et Biophysica Acta -Bioenergetics 1797 ( 4 ) 443 - 450 2010年04月
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Contribution of the FAD and quinone binding sites to the production of reactive oxygen species (ROS) from Ascaris suum mitochondrial complex II
Madhavi P Paranagama, Kimitoshi Sakamoto, Hisako Amino, Mutsumi Awano, Hideto Miyoshi, Kiyoshi Kit
Mitochondrion 10 ( 2 ) 158 - 165 2010年03月
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Crystallization and preliminary crystallographic analysis of cyanide-insensitive alternative oxidases from Trypanosoma brucei brucei
Yasutoshi Kido, Tomoo Shiba, Daniel Ken Inaoka, Kimitoshi Sakamoto, Takeshi Nara, Takashi Aoki, Teruki Honma, Akiko Tanaka, Masayuki Inoue, Sigeru Matsuoka, Anthony Moore, Sigeharu Harada, Kiyoshi Kita
Acta Crystallographica Section F 66 ( 3 ) 275 - 278 2010年03月
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Contribution of the FAD and quinone binding sites to the production of reactive oxygen species from Ascaris suum mitochondrial complex II.
Paranagama MP, Sakamoto K, Amino H, Awano M, Miyoshi H, Kita K
Mitochondrion 10 ( 2 ) 158 - 165 2010年03月
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Crystallization and preliminary crystallographic analysis of cyanide-insensitive alternative oxidase from Trypanosoma brucei brucei.
Kido Y, Shiba T, Inaoka DK, Sakamoto K, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Moore A, Harada S, Kita K
Acta crystallographica. Section F, Structural biology and crystallization communications 66 ( Pt 3 ) 275 - 278 2010年03月
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Crystallization of mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum with specific inhibitor, flutolanil
Arihiro Osanai, Shigeharu Harada, Kimitoshi Sakamoto, Hironari Shimizu, Daniel Ken Inaoka, Kiyoshi Kita
Acta Crystallographica Section F 65 ( 9 ) 941 - 944 2009年09月
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Crystallization of mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum with the specific inhibitor flutolanil.
Osanai A, Harada S, Sakamoto K, Shimizu H, Inaoka DK, Kita K
Acta crystallographica. Section F, Structural biology and crystallization communications 65 ( Pt 9 ) 941 - 944 2009年09月
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Novel Mitochondrial Complex II Isolated from Trypanosoma cruzi is Composed of Twelve Peptides Including a Heterodimeric Ip Subunit
Jorge Morales, Tatsushi Mogi, Shigeru Mineki, Eizo Takashima, Reiko Mineki, Hiroko Hirawake, Kimitoshi Sakamoto. Satoshi Omura, Kiyoshi Kita
The Journal of Biological Chemistry 284 ( 11 ) 7255 - 7263 2009年03月
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Novel mitochondrial complex II isolated from Trypanosoma cruzi is composed of 12 peptides including a heterodimeric Ip subunit.
Morales J, Mogi T, Mineki S, Takashima E, Mineki R, Hirawake H, Sakamoto K, Omura S, Kita K
The Journal of biological chemistry 284 ( 11 ) 7255 - 7263 2009年03月
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A tightly bound quinone functions in the ubiquinone reaction sites of quinoprotein alcohol dehydrogenase of an acetic acid bacterium, Gluconobacter suboxydans.
Matsushita K, Kobayashi Y, Mizuguchi M, Toyama H, Adachi O, Sakamoto K, Miyoshi H
Bioscience, biotechnology, and biochemistry 72 ( 10 ) 2723 - 2731 2008年10月
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Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction.
Inaoka DK, Sakamoto K, Shimizu H, Shiba T, Kurisu G, Nara T, Aoki T, Kita K, Harada S
Biochemistry 47 ( 41 ) 10881 - 10891 2008年10月
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Change of subunit composition of mitochondrial complex II (succinate-ubiquinone reductase/quinol-fumarate reductase) in Ascaris suum during the migration in the experimental host.
Iwata F, Shinjyo N, Amino H, Sakamoto K, Islam MK, Tsuji N, Kita K
Parasitology international 57 ( 1 ) 54 - 61 2008年03月
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Anaerobic NADH-fumarate reductase system is predominant in the respiratory chain of Echinococcus multilocularis, providing a novel target for the chemotherapy of alveolar echinococcosis.
Matsumoto J, Sakamoto K, Shinjyo N, Kido Y, Yamamoto N, Yagi K, Miyoshi H, Nonaka N, Katakura K, Kita K, Oku Y
Antimicrobial agents and chemotherapy 52 ( 1 ) 164 - 170 2008年01月
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Trypanosomu cruzi DHOD structure-based design of 5-halogen and 5-alkyl orotate derivatives
Inaoka Daniel K, Nayoung Lee, Sakamoto Kimitoshi, Shimizu Hironari, Shiba Tomoo, Kurisu Genji, Nara Takeshi, Aoki Takashi, Inoue Masayuki, Kita Kiyoshi, Harada Shigeharu
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 64 C222 2008年