Updated on 2023/01/17

写真a

 
HANADA Kenji
 
Affiliation
University Hospital Cardiology and Respiratory Medicine

Degree

  • 医学博士

Professional Memberships

  • 日本内科学会

  • 日本循環器学会

Papers

  • Reduced Left Ventricular Ejection Fraction Is a Risk for Sudden Cardiac Death in the Early Period After Hospital Discharge in Patients With Acute Myocardial Infarction

    Hanada Kenji, Sasaki Shingo, Seno Maiko, Kimura Yoshihiro, Ichikawa Hiroaki, Nishizaki Fumie, Yokoyama Hiroaki, Yokota Takashi, Okumura Ken, Tomita Hirofumi

    Circulation Journal   advpub ( 0 )   1490 - 1498   2022.3

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  • Rivaroxaban attenuates cardiac hypertrophy by inhibiting protease-activated receptor-2 signaling in renin-overexpressing hypertensive mice

    Narita Masato, Hanada Kenji, Kawamura Yosuke, Ichikawa Hiroaki, Sakai Shuntaro, Yokono Yoshikazu, Senoo Maiko, Narita Noritomo, Shimada Michiko, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi

    HYPERTENSION RESEARCH   44 ( 10 )   1261 - 1273   2021.10

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  • Diltiazem Inhibits Coronary Spasm via Inhibition of Cav1.2Phosphorylation and Protein Kinase C Activation in a Mouse Model of Coronary Spastic Angina

    Ishida Yuji, Kitayama Kazutaka, Hanada Kenji, Shibutani Shuji, Nishizaki Kimitaka, Kinjo Takahiko, Endo Tomohide, Suzuki Akiko, Tateyama Shunta, Nishizaki Fumie, Sukekawa Takanori, Tanaka Makoto, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi

    International Heart Journal   62 ( 4 )   910 - 918   2021.7

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  • A Case of Medically Treated Primary Chylopericardium

    Sakai Shuntaro, Nishizaki Fumie, Ashitate Toshihiro, Endo Tomohide, Shibutani Shuji, Hanada Kenji, Yokoyama Hiroaki, Yokota Takashi, Yamada Masahiro, Kakehata Shinya, Fukuda Ikuo, Tomita Hirofumi

    Shinzo   53 ( 7 )   737 - 742   2021.7

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  • Clinical impact of complete atrioventricular block in patients with ST-segment elevation myocardial infarction

    Kawamura Yosuke, Yokoyama Hiroaki, Kitayama Kazutaka, Miura Naotake, Hamadate Misato, Nagawa Daiki, Nozaka Masashi, Nakata Masamichi, Nishizaki Fumie, Hanada Kenji, Yokota Takashi, Yamada Masahiro, Higuma Takumi, Tomita Hirofumi

    CLINICAL CARDIOLOGY   44 ( 1 )   91 - 99   2021.1

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  • Characterizing genetic variants for DAG and IP3 signalling pathways in severe cases of coronary spastic angina

    Shibutani S., Yonekura M., Nosaka M., Kawamura Y., Hanada K., Kasai S., Yokota T., Higuma T., Itoh K., Tomita H.

    EUROPEAN HEART JOURNAL   41   1574 - 1574   2020.11

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  • Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A patient-pooled meta-analysis of randomized clinical trials

    Hoedemaker Niels P. G., Roolvink Vincent, de Winter Robbert J., van Royen Niels, Fuster Valentin, Garcia-Ruiz Jose M., Er Fikret, Gassanov Natig, Hanada Kenji, Okumura Ken, Ibanez Borja, van 't Hof Arnoud W., Damman Peter

    EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE   9 ( 5 )   469 - 477   2020.8

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  • Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice

    Yokono Yoshikazu, Hanada Kenji, Narita Masato, Tatara Yota, Kawamura Yousuke, Miura Naotake, Kitayama Kazutaka, Nakata Masamichi, Nozaka Masashi, Kato Tomo, Kudo Natsumi, Tsushima Michiko, Toyama Yuichi, Itoh Ken, Tomita Hirofumi

    JOURNAL OF THE AMERICAN HEART ASSOCIATION   9 ( 12 )   e015616   2020.6

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  • A case of takotsubo cardiomyopathy induced by steroid self-interruption during chemotherapy for prostate cancer

    Sakai Shuntaro, Nishizaki Fumie, Endo Tomohide, Shibutani Shuji, Hanada Kenji, Yokota Takashi, Tomita Hirofumi

    Shinzo   52 ( 1 )   70 - 74   2020.1

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  • Clinical Outcomes of Acute Myocardial Infarction Patients With a History of Malignant Tumor

    Nozaka Masashi, Yokoyama Hiroaki, Kitayama Kazutaka, Nagawa Daiki, Hamadate Misato, Miura Naotake, Kawamura Yosuke, Nakata Masamichi, Nishizaki Fumie, Hanada Kenji, Yokota Takashi, Yamada Masahiro, Tomita Hirofumi

    IN VIVO   34 ( 6 )   3589 - 3595   2020

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  • Incidence and clinical impact of thrombus after stent implantation in patients with ST-segment elevation myocardial infarction: an optical coherence tomography study

    Kato Tomo, Yokota Takashi, Nishizaki Fumie, Hanada Kenji, Nozaka Masashi, Yamada Masahiro, Kudo Natsumi, Yokono Yoshikazu, Toyama Yuichi

    Hirosaki Medical Journal   70 ( 2-4 )   139 - 147   2020

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  • Mutational analysis of β-arrestin in Japanese patients with coronary spastic angina

    Kudo Natsumi, Hanada Kenji, Kawamura Yosuke, Nakata Masamichi, Nozaka Masashi, Kitayama Kazutaka, Miura Naotake, Tanaka Makoto, Osanai Tomohiro

    Hirosaki Medical Journal   70 ( 2-4 )   148 - 155   2020

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  • Prognostic impact of body mass index and culprit lesion calcification in patients with acute myocardial infarction.

    Hiroaki Yokoyama, Takumi Higuma, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Takashi Yokota, Masahiro Yamada, Ken Okumura, Hirofumi Tomita

    Heart and vessels   34 ( 12 )   1909 - 1916   2019.12

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  • Prognostic impact of body mass index and culprit lesion calcification in patients with acute myocardial infarction

    Yokoyama Hiroaki, Higuma Takumi, Endo Tomohide, Nishizaki Fumie, Hanada Kenji, Yokota Takashi, Yamada Masahiro, Okumura Ken, Tomita Hirofumi

    HEART AND VESSELS   34 ( 12 )   1909 - 1916   2019.12

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  • Blockade of protease activated receptor-1 signaling attenuates cardiac hypertrophy and fibrosis in renin-overexpressing hypertensive mice

    Yokono Y., Narita M., Kawamura Y., Kato T., Kudo N., Tsushima M., Toyama Y., Hanada K., Shimada M., Makoto T., Osanai T., Tomita H.

    EUROPEAN HEART JOURNAL   40   926 - 926   2019.10

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  • Incidence and Outcomes of irregular protrusion after stent implantation in patients with acute myocardial infarction: An in in vivo optical coherence tomography study

    Kato T., Higuma T., Yokota T., Kudo N., Yokono Y., Senoo M., Narita N., Endo T., Nishizaki F., Shibutani S., Hanada K., Tomita H.

    EUROPEAN HEART JOURNAL   40   456 - 456   2019.10

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  • IQGAP1 activates PLC-δ1 by direct binding and moving along microtubule with DLC-1 to cell surface.

    Makoto Tanaka, Tomohiro Osanai, Yoshimi Homma, Kenji Hanada, Ken Okumura, Hirofumi Tomita

    FASEB bioAdvances   1 ( 8 )   465 - 480   2019.8

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  • IQGAP1 activates PLC-d1 by direct binding and moving along microtubule with DLC-1 to cell surface

    Tanaka Makoto, Osanai Tomohiro, Homma Yoshimi, Hanada Kenji, Okumura Ken, Tomita Hirofumi

    FASEB BIOADVANCES   1 ( 8 )   465 - 480   2019.8

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  • Involvement of β-Arrestin in Endothelin Receptor Signaling: A Possible Role in the Pathogenesis of Pulmonary Arterial Hypertension

    Narita Noritomo, Hanada Kenji, Senoo Maiko, Kato Tomo, Kudo Natsumi, Yokono Yoshikazu, Tsushima Michiko, Toyama Yuichi, Narita Masato

    Hirosaki Medical Journal   69 ( 1-4 )   146 - 154   2019.3

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  • COMPLETE ATRIOVENTRICULAR BLOCK IS A POOR PROGNOSTIC COMPLICATION IN PATIENTS WITH ANTERIOR ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN THE ERA OF PRIMARY PERCUTANEOUS CORONARY INTERVENTION

    Kawamura Yosuke, Higuma Takumi, Endo Tomohide, Nishizaki Fumie, Shibutani Shuji, Hanada Kenji, Yokoyama Hiroaki, Yokota Takashi, Yamada Masahiro, Tomita Hirofumi

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   73 ( 9 )   84 - 84   2019.3

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  • Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A patient-pooled meta-analysis of randomized clinical trials.

    Niels Pg Hoedemaker, Vincent Roolvink, Robbert J de Winter, Niels van Royen, Valentin Fuster, José M García-Ruiz, Fikret Er, Natig Gassanov, Kenji Hanada, Ken Okumura, Borja Ibáñez, Arnoud W van 't Hof, Peter Damman

    European heart journal. Acute cardiovascular care   2048872619830609 - 2048872619830609   2019.2

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  • Prasugrel versus clopidogrel for residual thrombus burden in patients with ST-segment elevation myocardial infarction: an optical coherence tomography study.

    Takashi Yokota, Takumi Higuma, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Hiroaki Yokoyama, Masahiro Yamada, Ken Okumura, Hirofumi Tomita

    Coronary artery disease   29 ( 8 )   663 - 669   2018.12

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  • Prasugrel versus clopidogrel for residual thrombus burden in patients with ST-segment elevation myocardial infarction: an optical coherence tomography study

    Yokota Takashi, Higuma Takumi, Endo Tomohide, Nishizaki Fumie, Hanada Kenji, Yokoyama Hiroaki, Yamada Masahiro, Okumura Ken, Tomita Hirofumi

    CORONARY ARTERY DISEASE   29 ( 8 )   663 - 669   2018.12

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  • Carvedilol Suppresses Coronary Spasm in A-Kinase Anchoring Protein 150 Knockout Mice: Its Novel Therapeutic Role in Coronary Spastic Angina

    Narita Noritomo, Hanada Kenji, Kawamura Yosuke, Nozaka Masashi, Kato Tomo, Kudo Natsumi, Yokono Yoshikazu, Senoo Maiko, Narita Masato, Tanaka Makoto, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi

    CIRCULATION   138   2018.11

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  • Inhibitory Effects of Rivaroxaban, a Direct Factor Xa Inhibitor, on Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice

    Narita Masato, Hanada Kenji, Yokono Yoshikazu, Senoo Maiko, Narita Noritomo, Kudo Natsumi, Kato Tomo, Nozaka Masashi, Kawamura Yosuke, Tanaka Makoto, Shimada Michiko, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi

    CIRCULATION   138   2018.11

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  • p122RhoGAP/DLC-1 Overexpression Enhances Intracellular Calcium Concentration and Causes Coronary Spasm: Potential Role for Coronary Spastic Angina

    Kudo Natsumi, Kimura Yoshihiro, Hanada Kenji, Kato Tomo, Tsushima Michiko, Toyama Yuichi, Yokono Yoshikazu, Senoo Maiko, Narita Noritomo, Narita Masato, Yonekura Manabu, Ichikawa Hiroaki, Tanaka Makoto, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi

    CIRCULATION   138   2018.11

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  • Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan.

    Yoshihiro Kimura, Masahiro Yamada, Kenji Hanada, Tomohide Endo, Noritomo Narita, Masato Narita, Maiko Senoo, Manabu Yonekura, Hiroaki Ichikawa, Shizuka Kurauchi, Shigeyuki Nakaji, Ken Okumura, Hirofumi Tomita

    International heart journal   59 ( 4 )   736 - 740   2018.7

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  • Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan

    Kimura Yoshihiro, Yamada Masahiro, Hanada Kenji, Endo Tomohide, Narita Noritomo, Narita Masato, Senoo Maiko, Yonekura Manabu, Ichikawa Hiroaki, Kurauchi Shizuka, Nakaji Shigeyuki, Okumura Ken, Tomita Hirofumi

    International Heart Journal   59 ( 4 )   736 - 740   2018.7

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  • Safety and Efficacy of Subcutaneous Cardioverter Defibrillator in Patients at High Risk of Sudden Cardiac Death ― Primary Japanese Experience ―

    Sasaki Shingo, Tomita Hirofumi, Tsurugi Takuo, Ishida Yuji, Shoji Yoshihiro, Nishizaki Kimitaka, Kinjo Takahiko, Endo Tomohide, Nishizaki Fumie, Hanada Kenji, Sasaki Kenichi, Horiuchi Daisuke, Kimura Masaomi, Higuma Takumi, Okamatsu Hideharu, Tanaka Yasuaki, Koyama Junjiroh, Okumura Ken

    Circulation Journal   82 ( 6 )   1546 - 1551   2018.5

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  • Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gα<sub>i</sub> coupling.

    Wang J, Hanada K, Gareri C, Rockman HA

    Journal of cellular biochemistry   119 ( 4 )   3586 - 3597   2018.4

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  • "30-minute-delta" of high-sensitivity troponin I improves diagnostic performance in acute myocardial infarction.

    Hiroaki Yokoyama, Takumi Higuma, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Takashi Yokota, Masahiro Yamada, Ken Okumura, Hirofumi Tomita

    Journal of cardiology   71 ( 2 )   144 - 148   2018.2

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  • "30-minute-delta" of high-sensitivity troponin I improves diagnostic performance in acute myocardial infarction

    Yokoyama Hiroaki, Higuma Takumi, Endo Tomohide, Nishizaki Fumie, Hanada Kenji, Yokota Takashi, Yamada Masahiro, Okumura Ken, Tomita Hirofumi

    JOURNAL OF CARDIOLOGY   71 ( 1-2 )   144 - 148   2018

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  • Gα<sub>i</sub> is required for carvedilol-induced β<sub>1</sub> adrenergic receptor β-arrestin biased signaling.

    Wang J, Hanada K, Staus DP, Makara MA, Dahal GR, Chen Q, Ahles A, Engelhardt S, Rockman HA

    Nature communications   8 ( 1 )   1706   2017.11

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  • Mechanical Stretch Activates Biased AT1R Signaling and a Distinct [beta]-arrestin Conformation

    Gareri Clarice, Wang Jialu, Hanada Kenji, Kashai Alem W., Xiong Xinyu, Rajagopal Sudarshan, Rockman Howard A.

    CIRCULATION RESEARCH   121   2017.7

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  • Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.

    Pironti G, Strachan RT, Abraham D, Mon-Wei Yu S, Chen M, Chen W, Hanada K, Mao L, Watson LJ, Rockman HA

    Circulation   131 ( 24 )   2120 - 30   2015.6

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  • Deeply reinverted T wave at 14 days after the onset of first anterior acute myocardial infarction predicts improved left ventricular function at 6 months.

    Hiroaki Yokoyama, Hirofumi Tomita, Fumie Nishizaki, Kenji Hanada, Shuji Shibutani, Masahiro Yamada, Naoki Abe, Takumi Higuma, Tomohiro Osanai, Ken Okumura

    Clinical cardiology   38 ( 3 )   157 - 163   2015.3

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  • Deeply Reinverted T Wave at 14 Days After the Onset of First Anterior Acute Myocardial Infarction Predicts Improved Left Ventricular Function at 6 Months

    Yokoyama Hiroaki, Tomita Hirofumi, Nishizaki Fumie, Hanada Kenji, Shibutani Shuji, Yamada Masahiro, Abe Naoki, Higuma Takumi, Osanai Tomohiro, Okumura Ken

    CLINICAL CARDIOLOGY   38 ( 3 )   157 - 163   2015.3

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  • Plasma soluble lectin-like oxidized low-density lipoprotein receptor-1 as a novel prognostic biomarker in patients with ST-segment elevation acute myocardial infarction.

    Takumi Higuma, Naoki Abe, Syunta Tateyama, Tomohide Endo, Shuji Shibutani, Hiroaki Yokoyama, Kenji Hanada, Masahiro Yamada, Hirofumi Tomita, Hiroyuki Hanada, Tomohiro Osanai, Noriaki Kume, Ken Okumura

    Circulation journal : official journal of the Japanese Circulation Society   79 ( 3 )   641 - 648   2015

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  • Plasma Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 as a Novel Prognostic Biomarker in Patients With ST-Segment Elevation Acute Myocardial Infarction

    Higuma Takumi, Abe Naoki, Tateyama Syunta, Endo Tomohide, Shibutani Shuji, Yokoyama Hiroaki, Hanada Kenji, Yamada Masahiro, Tomita Hirofumi, Hanada Hiroyuki, Osanai Tomohiro, Kume Noriaki, Okumura Ken

    Circulation Journal   79 ( 3 )   641 - 648   2015

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  • PLAQUE RUPTURE IS ASOCIATED WITH WORSE REPERFUSION OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

    Higuma Takumi, Abe Naoki, Tateyama Shunta, Shibutani Shuji, Hanada Kenji, Yokoyama Hiroaki, Yamada Masahiro, Osanai Tomohiro, Okumura Ken

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   63 ( 12 )   A71 - A71   2014.4

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  • Stent malapposition, as a potential mechanism of very late stent thrombosis after bare-metal stent implantation: a case report.

    Takumi Higuma, Naoki Abe, Kenji Hanada, Hiroaki Yokoyama, Hirofumi Tomita, Ken Okumura

    Cardiovascular revascularization medicine : including molecular interventions   15 ( 3 )   178 - 181   2014.4

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  • Stent malapposition, as a potential mechanism of very late stent thrombosis after bare-metal stent implantation: a case report.

    Higuma T, Abe N, Hanada K, Yokoyama H, Tomita H, Okumura K

    Cardiovascular revascularization medicine : including molecular interventions   15 ( 3 )   178 - 81   2014.4

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  • Follow-up Coronary Angiography at Chronic Phase is Beneficial in Patients With Acute Myocardial Infarction

    Abe Naoki, Higuma Takumi, Tateyama Syunta, Endeo Tomohide, Hanada Kenji, Shibutani Syuji, Yokoyama Hiroaki, Yamada Masahiro, Tomita Hirofumi, Hanada Hiroyuki, Osanai Tomohiro, Okumura Ken

    CIRCULATION   128 ( 22 )   2013.11

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  • Plasma Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-1 as a Novel Prognostic Biomaker in Patients With ST-elevation Acute Myocardial Infarction

    Higuma Takumi, Abe Naoki, Tateyama Shunta, Endo Tomohide, Hanada Kenji, Shibutani Syuuji, Yamada Masahiro, Tomita Hirofumi, Hanada Hiroyuki, Osanai Tomohiro, Kume Noriaki, Okumura Ken

    CIRCULATION   128 ( 22 )   2013.11

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  • The Incidence, Characteristics, And Outcome Of Cardiac Rupture In Patients With Acute Myocardial Infarction In The Primary PCI Era

    Hanada Kenji, Higuma Takumi, Osanai Tomohiro, Okumura Ken

    CIRCULATION   128 ( 22 )   2013.11

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  • Plasma Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Level at Admission can Predict Mortality in Patients with Acute Myocardial Infarction

    Higuma Takumi, Abe Naoki, Endo Tomohide, Tateyama Shunta, Hanada Kenji, Yokoyama Hiroaki, Echizen Takashi, Yokota Takashi, Saito Shin, Tomita Hirofumi, Hanada Hiroyuki, Osanai Tomohiro, Kume Noriaki, Okumura Ken

    CIRCULATION   126 ( 21 )   2012.11

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  • Randomized study on the efficacy and safety of landiolol, an ultra-short-acting β1-adrenergic blocker, in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.

    Kenji Hanada, Takumi Higuma, Fumie Nishizaki, Takanori Sukekawa, Takashi Yokota, Masahiro Yamada, Shin Saito, Motoi Kushibiki, Koichi Oikawa, Naoki Abe, Hirofumi Tomita, Tomohiro Osanai, Ken Okumura

    Circulation journal : official journal of the Japanese Circulation Society   76 ( 2 )   439 - 445   2012.4

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  • Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice.

    Shigeki Sagara, Tomohiro Osanai, Taihei Itoh, Kei Izumiyama, Shuji Shibutani, Kenji Hanada, Hiroaki Yokoyama, Yuko Yamamoto, Takashi Yokota, Hirofumi Tomita, Koji Magota, Ken Okumura

    Journal of hypertension   30 ( 4 )   778 - 786   2012.4

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  • Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice

    Sagara Shigeki, Osanai Tomohiro, Itoh Taihei, Izumiyama Kei, Shibutani Shuji, Hanada Kenji, Yokoyama Hiroaki, Yamamoto Yuko, Yokota Takashi, Tomita Hirofumi, Magota Koji, Okumura Ken

    JOURNAL OF HYPERTENSION   30 ( 4 )   778 - 786   2012.4

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  • Coronary vasospasm induced in transgenic mouse with increased phospholipase C-δ1 activity.

    Shuji Shibutani, Tomohiro Osanai, Toshihiro Ashitate, Shigeki Sagara, Kei Izumiyama, Yuko Yamamoto, Kenji Hanada, Takashi Echizen, Hirofumi Tomita, Takeshi Fujita, Takeshi Miwa, Hiroaki Matsubara, Yoshimi Homma, Ken Okumura

    Circulation   125 ( 8 )   1027 - 1036   2012.2

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  • Coronary Vasospasm Induced in Transgenic Mouse With Increased Phospholipase C-delta 1 Activity

    Shibutani Shuji, Osanai Tomohiro, Ashitate Toshihiro, Sagara Shigeki, Izumiyama Kei, Yamamoto Yuko, Hanada Kenji, Echizen Takashi, Tomita Hirofumi, Fujita Takeshi, Miwa Takeshi, Matsubara Hiroaki, Homma Yoshimi, Okumura Ken

    CIRCULATION   125 ( 8 )   1027 - 1036   2012.2

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  • Randomized Study on the Efficacy and Safety of Landiolol, an Ultra-Short-Acting .BETA.1-Adrenergic Blocker, in Patients With Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

    Hanada Kenji, Higuma Takumi, Nishizaki Fumie, Sukekawa Takanori, Yokota Takashi, Yamada Masahiro, Saito Shin, Kushibiki Motoi, Oikawa Koichi, Abe Naoki, Tomita Hirofumi, Osanai Tomohiro, Okumura Ken

    Circulation Journal   76 ( 2 )   439 - 445   2012

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  • Overexpression of Coupling Factor 6 Attenuates Exercise-Induced Physiological Cardiac Hypertrophy By Inhibiting Pi3k/akt Signaling in Mice

    Sagara Shigeki, Osanai Tomihiro, Suzuki Akiko, Nishizaki Fumie, Sukekawa Takanori, Itoh Taihei, Izumiyama Kei, Shibutani Shuji, Hanada Kenji, Yamamoto Yuko, Yokoyama Hiroaki, Yokota Takashi, Tomita Hirofumi, Okumura Ken

    CIRCULATION   124 ( 21 )   2011.11

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  • Inhibition of P38 MAP Kinase Attenuates Left Ventricular Hypertrophy and Inhibits Progression of Systolic Dysfunction on Pressure-Overload Induced Pathological Cardiac Hypertrophy in Mice

    Hanada Kenji, Osanai Tomohiro, Sukekawa Takanori, Ohya Fumie, Isumiyama Kei, Sagara Shigeki, Ito Taihei, Yamamoto Yuko, Shibutani Shuji, Tomita Hirofumi, Okumura Ken

    The Hirosaki medical journal   62 ( 1 )   18 - 26   2011.4

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  • Mutation Analysis ABCC9 Gene in Japanese Patients with Coronary Spastic Angina

    Shibutani Shuji, Osanai Tomohiro, Oya Humie, Sagara Shigeki, Izumiyama Kei, Yamamoto Yuko, Hanada Kenji, Tomita Hirofumi, Okumura Ken

    The Hirosaki medical journal   62 ( 1 )   27 - 33   2011.4

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  • Inhibition of p38 MAP kinase attenuates left ventricular hypertrophy and inhibits progression of systolic dysfunction on pressure-overload induced pathological cardiac hypertrophy in mice

    Hanada Kenji, Osanai Tomohiro, Sukekawa Takanori, Ohya Fumie, Izumiyama Kei, Sagara Shigeki, Ito Taihei, Yamamoto Yuko, Shibutani Shuji, Tomita Hirofumi, Okumura Ken

    Hirosaki Medical Journal   62 ( 1 )   18 - 26   2011

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  • Mutation analysis of ABCC9 gene in Japanese patients with coronary spastic angina

    Shibutani Shuji, Osanai Tomohiro, Ohya Humie, Sagara Shigeki, Izumiyama Kei, Yamamoto Yuko, Hanada Kenji, Tomita Hirofumi, Okumura Ken

    Hirosaki Medical Journal   62 ( 1 )   27 - 33   2011

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  • Overexpression of Coupling Factor 6 Attenuates Physiological Cardiac Hypertrophy Induced by Swimming and Causes Systolic Cardiac Dysfunction in Mice

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    CIRCULATION   122 ( 21 )   2010.11

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  • Overexpression of Coupling Factor 6 Causes Salt-Sensitive Hypertension and Systolic Cardiac Dysfunction: Gender as an Important Modulator

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    CIRCULATION   122 ( 21 )   2010.11

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  • Effects of telmisartan on markers of ventricular remodeling in patients with acute myocardial infarction: comparison with enalapril.

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    Heart and vessels   25 ( 6 )   460 - 468   2010.11

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  • Overexpression of coupling factor 6 causes cardiac dysfunction under high-salt diet in mice.

    Toshihiro Ashitate, Tomohiro Osanai, Makoto Tanaka, Koji Magota, Takashi Echizen, Kei Izumiyama, Hiroaki Yokoyama, Shuji Shibutani, Kenji Hanada, Hirofumi Tomita, Ken Okumura

    Journal of hypertension   28 ( 11 )   2243 - 2251   2010.11

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  • Effects of telmisartan on markers of ventricular remodeling in patients with acute myocardial infarction: comparison with enalapril

    Yokota Takashi, Osanai Tomohiro, Hanada Kenji, Kushibiki Motoi, Abe Naoki, Oikawa Koichi, Tomita Hirofumi, Higuma Takumi, Yokoyama Jin, Hanada Hiroyuki, Okumura Ken

    HEART AND VESSELS   25 ( 6 )   460 - 468   2010.11

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  • Overexpression of coupling factor 6 causes cardiac dysfunction under high-salt diet in mice

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    JOURNAL OF HYPERTENSION   28 ( 11 )   2243 - 2251   2010.11

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  • OE-070 Plasma Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-1 Level at Admission can Predict In-hospital Prognosis in Patients with Acute Myocardial Infarction(OE12,ACS/AMI (Clinical/Pathophysiology) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Higuma Takumi, Hanada Kenji, Abe Naoki, Oikawa Koichi, Kushibiki Motoi, Yokota Takashi, Yamamoto Yuko, Ohya Fumie, Hanada Hiroyuki, Osanai Tomohiro, Kume Noriaki, Okumura Ken

    Circulation journal : official journal of the Japanese Circulation Society   73 ( 0 )   191   2009.3

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  • OJ-186 Efficacy and Safety of Landiolol, an Ultra Short-acting, β 1-selective Adrenergic Blocker, in Patients with Acute Myocardial Infarction Undergoing PCI(OJ31,ACS/AMI (Clinical/Treatment) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

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    Circulation journal : official journal of the Japanese Circulation Society   73 ( 0 )   332 - 333   2009.3

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  • Amiodarone attenuates the upregulated matrix metalloproteinase-2 activity in a rat myocardial infarction model

    Horiuchi Daisuke, Osanai Tomohiro, Echizen Takashi, Ashitate Toshihiro, Katoh Chisato, Yokoyama Hiroaki, Hanada Kenji, Shibutani Shuji, Itoh Taihei, Okumura Ken

    Hirosaki Medical Journal   60 ( 1-4 )   45 - 53   2009

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  • Upregulation of insulin-like growth factor-1 gene expression in cardiac myocytes by hypoxia : mechanism for its cardioprotective effect

    Katoh Chisato, Osanai Tomohiro, Shibutani Shuji, Hanada Kenji, Okumura Ken

    Hirosaki Medical Journal   60 ( 1-4 )   36 - 44   2009

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  • 20)高度房室ブロックならびに流出路圧較差を生じたたこつぼ型心筋障害の一例(第144回日本循環器学会東北地方会)

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    71 ( 0 )   984   2007.10

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  • 43)高齢のFallot修復術後に出現した左心不全に対し心臓再同期療法が有効であった1例(第143回日本循環器学会東北地方会)

    渋谷 修司, 佐々木 真吾, 花田 賢二, 横田 貴志, 及川 広一, 阿部 直樹, 富田 泰史, 木村 正臣, 樋熊 拓未, 横山 仁, 花田 裕之, 長内 智宏, 奥村 謙

    71 ( 0 )   930   2007.10

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  • 21)心房梗塞によりアトロピン無効の徐脈低血圧をきたした1例(第143回日本循環器学会東北地方会)

    花田 賢二, 樋熊 拓未, 渋谷 修司, 横田 貴志, 及川 広一, 阿部 直樹, 富田 泰史, 木村 正臣, 佐々木 真吾, 横山 仁, 花田 裕之, 長内 智宏, 奥村 謙

    71 ( 0 )   927   2007.10

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  • Novel ferrochelatase mutations in Japanese patients with erythropoietic protoporphyria: High frequency of the splice site modulator IVS3-48C polymorphism in the Japanese population

    Nakano Hajime, Nakano Aoi, Toyomaki Yuka, Ohashi Shigeki, Harada Ken, Moritsugu Ryuta, Takeda Hitoshi, Kawada Akira, Mitsuhashi Yoshihiko, Hanada Katsumi

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   126 ( 12 )   2717 - 2719   2006.12

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