経カテーテル的大動脈弁留置術中の経食道心エコーにて乳頭状線維弾性腫が疑われた2症例

酒井 峻太郎, 横山 公章, 市川 博章, 木村 嘉宏, 西崎 史恵, 花田 賢二, 横田 貴志, 山田 雅大, 富田 泰史

心臓   54 ( 1 )   100 - 105   2022年01月

Rivaroxaban attenuates cardiac hypertrophy by inhibiting protease-activated receptor-2 signaling in renin-overexpressing hypertensive mice

Narita Masato, Hanada Kenji, Kawamura Yosuke, Ichikawa Hiroaki, Sakai Shuntaro, Yokono Yoshikazu, Senoo Maiko, Narita Noritomo, Shimada Michiko, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi

HYPERTENSION RESEARCH   44 ( 10 )   1261 - 1273   2021年10月

Diltiazem Inhibits Coronary Spasm via Inhibition of Cav1.2 Phosphorylation and Protein Kinase C Activation in a Mouse Model of Coronary Spastic Angina

Ishida Yuji, Kitayama Kazutaka, Hanada Kenji, Shibutani Shuji, Nishizaki Kimitaka, Kinjo Takahiko, Endo Tomohide, Suzuki Akiko, Tateyama Shunta, Nishizaki Fumie, Sukekawa Takanori, Tanaka Makoto, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi

Japanese Heart Journal   62 ( 4 )   910 - 918   2021年07月

内科的治療で心嚢液の減少を認めた原発性乳糜心膜症の1例

酒井 峻太郎, 西崎 史恵, 芦立 俊宗, 遠藤 知秀, 澁谷 修司, 花田 賢二, 横山 公章, 横田 貴志, 山田 雅大, 掛端 伸也, 福田 幾夫, 富田 泰史

心臓   53 ( 7 )   737 - 742   2021年07月

Clinical impact of complete atrioventricular block in patients with ST-segment elevation myocardial infarction

Kawamura Yosuke, Yokoyama Hiroaki, Kitayama Kazutaka, Miura Naotake, Hamadate Misato, Nagawa Daiki, Nozaka Masashi, Nakata Masamichi, Nishizaki Fumie, Hanada Kenji, Yokota Takashi, Yamada Masahiro, Higuma Takumi, Tomita Hirofumi

CLINICAL CARDIOLOGY   44 ( 1 )   91 - 99   2021年01月

Characterizing genetic variants for DAG and IP3 signalling pathways in severe cases of coronary spastic angina

Shibutani S., Yonekura M., Nosaka M., Kawamura Y., Hanada K., Kasai S., Yokota T., Higuma T., Itoh K., Tomita H.

EUROPEAN HEART JOURNAL   41   1574 - 1574   2020年11月

Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A patient-pooled meta-analysis of randomized clinical trials

Hoedemaker Niels P. G., Roolvink Vincent, de Winter Robbert J., van Royen Niels, Fuster Valentin, Garcia-Ruiz Jose M., Er Fikret, Gassanov Natig, Hanada Kenji, Okumura Ken, Ibanez Borja, van 't Hof Arnoud W., Damman Peter

EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE   9 ( 5 )   469 - 477   2020年08月

Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice

Yokono Yoshikazu, Hanada Kenji, Narita Masato, Tatara Yota, Kawamura Yousuke, Miura Naotake, Kitayama Kazutaka, Nakata Masamichi, Nozaka Masashi, Kato Tomo, Kudo Natsumi, Tsushima Michiko, Toyama Yuichi, Itoh Ken, Tomita Hirofumi

JOURNAL OF THE AMERICAN HEART ASSOCIATION   9 ( 12 )   e015616   2020年06月

前立腺癌で加療中にたこつぼ型心筋症を発症し，後にステロイド自己中断による副腎不全が判明した1例

酒井 峻太郎, 西崎 史恵, 遠藤 知秀, 澁谷 修司, 花田 賢二, 横田 貴志, 富田 泰史

心臓   52 ( 1 )   70 - 74   2020年01月

Mutational analysis of β-arrestin in Japanese patients with coronary spastic angina

Kudo Natsumi, Hanada Kenji, Kawamura Yosuke, Nakata Masamichi, Nozaka Masashi, Kitayama Kazutaka, Miura Naotake, Tanaka Makoto, Osanai Tomohiro

Hirosaki Medical Journal   70 ( 2-4 )   148 - 155   2020年

Incidence and clinical impact of thrombus after stent implantation in patients with ST-segment elevation myocardial infarction: an optical coherence tomography study

Kato Tomo, Yokota Takashi, Nishizaki Fumie, Hanada Kenji, Nozaka Masashi, Yamada Masahiro, Kudo Natsumi, Yokono Yoshikazu, Toyama Yuichi

Hirosaki Medical Journal   70 ( 2-4 )   139 - 147   2020年

Clinical Outcomes of Acute Myocardial Infarction Patients With a History of Malignant Tumor

Nozaka Masashi, Yokoyama Hiroaki, Kitayama Kazutaka, Nagawa Daiki, Hamadate Misato, Miura Naotake, Kawamura Yosuke, Nakata Masamichi, Nishizaki Fumie, Hanada Kenji, Yokota Takashi, Yamada Masahiro, Tomita Hirofumi

IN VIVO   34 ( 6 )   3589 - 3595   2020年

Prognostic impact of body mass index and culprit lesion calcification in patients with acute myocardial infarction.

Hiroaki Yokoyama, Takumi Higuma, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Takashi Yokota, Masahiro Yamada, Ken Okumura, Hirofumi Tomita

Heart and vessels   34 ( 12 )   1909 - 1916   2019年12月

Prognostic impact of body mass index and culprit lesion calcification in patients with acute myocardial infarction

Yokoyama Hiroaki, Higuma Takumi, Endo Tomohide, Nishizaki Fumie, Hanada Kenji, Yokota Takashi, Yamada Masahiro, Okumura Ken, Tomita Hirofumi

HEART AND VESSELS   34 ( 12 )   1909 - 1916   2019年12月

Blockade of protease activated receptor-1 signaling attenuates cardiac hypertrophy and fibrosis in renin-overexpressing hypertensive mice

Yokono Y., Narita M., Kawamura Y., Kato T., Kudo N., Tsushima M., Toyama Y., Hanada K., Shimada M., Makoto T., Osanai T., Tomita H.

EUROPEAN HEART JOURNAL   40   926 - 926   2019年10月

Incidence and Outcomes of irregular protrusion after stent implantation in patients with acute myocardial infarction: An in in vivo optical coherence tomography study

Kato T., Higuma T., Yokota T., Kudo N., Yokono Y., Senoo M., Narita N., Endo T., Nishizaki F., Shibutani S., Hanada K., Tomita H.

EUROPEAN HEART JOURNAL   40   456 - 456   2019年10月

IQGAP1 activates PLC-δ1 by direct binding and moving along microtubule with DLC-1 to cell surface.

Makoto Tanaka, Tomohiro Osanai, Yoshimi Homma, Kenji Hanada, Ken Okumura, Hirofumi Tomita

FASEB bioAdvances   1 ( 8 )   465 - 480   2019年08月

IQGAP1 activates PLC-d1 by direct binding and moving along microtubule with DLC-1 to cell surface

Tanaka Makoto, Osanai Tomohiro, Homma Yoshimi, Hanada Kenji, Okumura Ken, Tomita Hirofumi

FASEB BIOADVANCES   1 ( 8 )   465 - 480   2019年08月

Involvement of β-Arrestin in Endothelin Receptor Signaling: A Possible Role in the Pathogenesis of Pulmonary Arterial Hypertension

Narita Noritomo, Hanada Kenji, Senoo Maiko, Kato Tomo, Kudo Natsumi, Yokono Yoshikazu, Tsushima Michiko, Toyama Yuichi, Narita Masato

Hirosaki Medical Journal   69 ( 1-4 )   146 - 154   2019年03月

COMPLETE ATRIOVENTRICULAR BLOCK IS A POOR PROGNOSTIC COMPLICATION IN PATIENTS WITH ANTERIOR ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN THE ERA OF PRIMARY PERCUTANEOUS CORONARY INTERVENTION

Kawamura Yosuke, Higuma Takumi, Endo Tomohide, Nishizaki Fumie, Shibutani Shuji, Hanada Kenji, Yokoyama Hiroaki, Yokota Takashi, Yamada Masahiro, Tomita Hirofumi

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   73 ( 9 )   84 - 84   2019年03月

Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A patient-pooled meta-analysis of randomized clinical trials.

Niels Pg Hoedemaker, Vincent Roolvink, Robbert J de Winter, Niels van Royen, Valentin Fuster, José M García-Ruiz, Fikret Er, Natig Gassanov, Kenji Hanada, Ken Okumura, Borja Ibáñez, Arnoud W van 't Hof, Peter Damman

European heart journal. Acute cardiovascular care   2048872619830609 - 2048872619830609   2019年02月

Prasugrel versus clopidogrel for residual thrombus burden in patients with ST-segment elevation myocardial infarction: an optical coherence tomography study.

Takashi Yokota, Takumi Higuma, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Hiroaki Yokoyama, Masahiro Yamada, Ken Okumura, Hirofumi Tomita

Coronary artery disease   29 ( 8 )   663 - 669   2018年12月

Prasugrel versus clopidogrel for residual thrombus burden in patients with ST-segment elevation myocardial infarction: an optical coherence tomography study

Yokota Takashi, Higuma Takumi, Endo Tomohide, Nishizaki Fumie, Hanada Kenji, Yokoyama Hiroaki, Yamada Masahiro, Okumura Ken, Tomita Hirofumi

CORONARY ARTERY DISEASE   29 ( 8 )   663 - 669   2018年12月

Carvedilol Suppresses Coronary Spasm in A-Kinase Anchoring Protein 150 Knockout Mice: Its Novel Therapeutic Role in Coronary Spastic Angina

Narita Noritomo, Hanada Kenji, Kawamura Yosuke, Nozaka Masashi, Kato Tomo, Kudo Natsumi, Yokono Yoshikazu, Senoo Maiko, Narita Masato, Tanaka Makoto, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi

CIRCULATION   138   2018年11月

p122RhoGAP/DLC-1 Overexpression Enhances Intracellular Calcium Concentration and Causes Coronary Spasm: Potential Role for Coronary Spastic Angina

Kudo Natsumi, Kimura Yoshihiro, Hanada Kenji, Kato Tomo, Tsushima Michiko, Toyama Yuichi, Yokono Yoshikazu, Senoo Maiko, Narita Noritomo, Narita Masato, Yonekura Manabu, Ichikawa Hiroaki, Tanaka Makoto, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi

CIRCULATION   138   2018年11月

Inhibitory Effects of Rivaroxaban, a Direct Factor Xa Inhibitor, on Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice

Narita Masato, Hanada Kenji, Yokono Yoshikazu, Senoo Maiko, Narita Noritomo, Kudo Natsumi, Kato Tomo, Nozaka Masashi, Kawamura Yosuke, Tanaka Makoto, Shimada Michiko, Osanai Tomohiro, Okumura Ken, Tomita Hirofumi

CIRCULATION   138   2018年11月

Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan.

Yoshihiro Kimura, Masahiro Yamada, Kenji Hanada, Tomohide Endo, Noritomo Narita, Masato Narita, Maiko Senoo, Manabu Yonekura, Hiroaki Ichikawa, Shizuka Kurauchi, Shigeyuki Nakaji, Ken Okumura, Hirofumi Tomita

International heart journal   59 ( 4 )   736 - 740   2018年07月

Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan Analysis of the Iwaki Health Promotion Project

Kimura Yoshihiro, Yamada Masahiro, Hanada Kenji, Endo Tomohide, Narita Noritomo, Narita Masato, Senoo Maiko, Yonekura Manabu, Ichikawa Hiroaki, Kurauchi Shizuka, Nakaji Shigeyuki, Okumura Ken, Tomita Hirofumi

Japanese Heart Journal   59 ( 4 )   736 - 740   2018年07月

Safety and efficacy of the subcutaneous cardioverter-defibrillator in patients at high risk of sudden cardiac death: Primary Japanese experience.

Sasaki Shingo, Tomita Hirofumi, Tsurugi Takuo, Ishida Yuji, Shoji Yoshihiro, Nishizaki Kimitaka, Kinjo Takahiko, Endo Tomohide, Nishizaki Fumie, Hanada Kenji, Sasaki Kenichi, Horiuchi Daisuke, Kimura Masaomi, Higuma Takumi, Okamatsu Hideharu, Tanaka Yasuaki, Koyama Junjiroh, Okumura Ken

日本循環器學誌   82 ( 6 )   1546 - 1551   2018年05月

Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gα_i coupling.

Wang J, Hanada K, Gareri C, Rockman HA

Journal of cellular biochemistry   119 ( 4 )   3586 - 3597   2018年04月

"30-minute-delta" of high-sensitivity troponin I improves diagnostic performance in acute myocardial infarction.

Hiroaki Yokoyama, Takumi Higuma, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Takashi Yokota, Masahiro Yamada, Ken Okumura, Hirofumi Tomita

Journal of cardiology   71 ( 2 )   144 - 148   2018年02月

"30-minute-delta" of high-sensitivity troponin I improves diagnostic performance in acute myocardial infarction

Yokoyama Hiroaki, Higuma Takumi, Endo Tomohide, Nishizaki Fumie, Hanada Kenji, Yokota Takashi, Yamada Masahiro, Okumura Ken, Tomita Hirofumi

JOURNAL OF CARDIOLOGY   71 ( 1-2 )   144 - 148   2018年

Gα_i is required for carvedilol-induced β₁ adrenergic receptor β-arrestin biased signaling.

Wang J, Hanada K, Staus DP, Makara MA, Dahal GR, Chen Q, Ahles A, Engelhardt S, Rockman HA

Nature communications   8 ( 1 )   1706   2017年11月

Mechanical Stretch Activates Biased AT1R Signaling and a Distinct [beta]-arrestin Conformation

Gareri Clarice, Wang Jialu, Hanada Kenji, Kashai Alem W., Xiong Xinyu, Rajagopal Sudarshan, Rockman Howard A.

CIRCULATION RESEARCH   121   2017年07月

Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.

Pironti G, Strachan RT, Abraham D, Mon-Wei Yu S, Chen M, Chen W, Hanada K, Mao L, Watson LJ, Rockman HA

Circulation   131 ( 24 )   2120 - 30   2015年06月

Deeply reinverted T wave at 14 days after the onset of first anterior acute myocardial infarction predicts improved left ventricular function at 6 months.

Hiroaki Yokoyama, Hirofumi Tomita, Fumie Nishizaki, Kenji Hanada, Shuji Shibutani, Masahiro Yamada, Naoki Abe, Takumi Higuma, Tomohiro Osanai, Ken Okumura

Clinical cardiology   38 ( 3 )   157 - 163   2015年03月

Deeply Reinverted T Wave at 14 Days After the Onset of First Anterior Acute Myocardial Infarction Predicts Improved Left Ventricular Function at 6 Months

Yokoyama Hiroaki, Tomita Hirofumi, Nishizaki Fumie, Hanada Kenji, Shibutani Shuji, Yamada Masahiro, Abe Naoki, Higuma Takumi, Osanai Tomohiro, Okumura Ken

CLINICAL CARDIOLOGY   38 ( 3 )   157 - 163   2015年03月

Plasma soluble lectin-like oxidized low-density lipoprotein receptor-1 as a novel prognostic biomarker in patients with ST-segment elevation acute myocardial infarction.

Takumi Higuma, Naoki Abe, Syunta Tateyama, Tomohide Endo, Shuji Shibutani, Hiroaki Yokoyama, Kenji Hanada, Masahiro Yamada, Hirofumi Tomita, Hiroyuki Hanada, Tomohiro Osanai, Noriaki Kume, Ken Okumura

Circulation journal : official journal of the Japanese Circulation Society   79 ( 3 )   641 - 648   2015年

Plasma Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 as a Novel Prognostic Biomarker in Patients With ST-Segment Elevation Acute Myocardial Infarction

Higuma Takumi, Abe Naoki, Tateyama Syunta, Endo Tomohide, Shibutani Shuji, Yokoyama Hiroaki, Hanada Kenji, Yamada Masahiro, Tomita Hirofumi, Hanada Hiroyuki, Osanai Tomohiro, Kume Noriaki, Okumura Ken

日本循環器學誌   79 ( 3 )   641 - 648   2015年

PLAQUE RUPTURE IS ASOCIATED WITH WORSE REPERFUSION OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Higuma Takumi, Abe Naoki, Tateyama Shunta, Shibutani Shuji, Hanada Kenji, Yokoyama Hiroaki, Yamada Masahiro, Osanai Tomohiro, Okumura Ken

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   63 ( 12 )   A71 - A71   2014年04月

Stent malapposition, as a potential mechanism of very late stent thrombosis after bare-metal stent implantation: a case report.

Takumi Higuma, Naoki Abe, Kenji Hanada, Hiroaki Yokoyama, Hirofumi Tomita, Ken Okumura

Cardiovascular revascularization medicine : including molecular interventions   15 ( 3 )   178 - 181   2014年04月

Stent malapposition, as a potential mechanism of very late stent thrombosis after bare-metal stent implantation: a case report.

Higuma T, Abe N, Hanada K, Yokoyama H, Tomita H, Okumura K

Cardiovascular revascularization medicine : including molecular interventions   15 ( 3 )   178 - 81   2014年04月

Follow-up Coronary Angiography at Chronic Phase is Beneficial in Patients With Acute Myocardial Infarction

Abe Naoki, Higuma Takumi, Tateyama Syunta, Endeo Tomohide, Hanada Kenji, Shibutani Syuji, Yokoyama Hiroaki, Yamada Masahiro, Tomita Hirofumi, Hanada Hiroyuki, Osanai Tomohiro, Okumura Ken

CIRCULATION   128 ( 22 )   2013年11月

The Incidence, Characteristics, And Outcome Of Cardiac Rupture In Patients With Acute Myocardial Infarction In The Primary PCI Era

Hanada Kenji, Higuma Takumi, Osanai Tomohiro, Okumura Ken

CIRCULATION   128 ( 22 )   2013年11月

Plasma Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-1 as a Novel Prognostic Biomaker in Patients With ST-elevation Acute Myocardial Infarction

Higuma Takumi, Abe Naoki, Tateyama Shunta, Endo Tomohide, Hanada Kenji, Shibutani Syuuji, Yamada Masahiro, Tomita Hirofumi, Hanada Hiroyuki, Osanai Tomohiro, Kume Noriaki, Okumura Ken

CIRCULATION   128 ( 22 )   2013年11月

Plasma Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Level at Admission can Predict Mortality in Patients with Acute Myocardial Infarction

Higuma Takumi, Abe Naoki, Endo Tomohide, Tateyama Shunta, Hanada Kenji, Yokoyama Hiroaki, Echizen Takashi, Yokota Takashi, Saito Shin, Tomita Hirofumi, Hanada Hiroyuki, Osanai Tomohiro, Kume Noriaki, Okumura Ken

CIRCULATION   126 ( 21 )   2012年11月

Randomized study on the efficacy and safety of landiolol, an ultra-short-acting β1-adrenergic blocker, in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.

Kenji Hanada, Takumi Higuma, Fumie Nishizaki, Takanori Sukekawa, Takashi Yokota, Masahiro Yamada, Shin Saito, Motoi Kushibiki, Koichi Oikawa, Naoki Abe, Hirofumi Tomita, Tomohiro Osanai, Ken Okumura

Circulation journal : official journal of the Japanese Circulation Society   76 ( 2 )   439 - 445   2012年04月

Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice.

Shigeki Sagara, Tomohiro Osanai, Taihei Itoh, Kei Izumiyama, Shuji Shibutani, Kenji Hanada, Hiroaki Yokoyama, Yuko Yamamoto, Takashi Yokota, Hirofumi Tomita, Koji Magota, Ken Okumura

Journal of hypertension   30 ( 4 )   778 - 786   2012年04月

Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice

Sagara Shigeki, Osanai Tomohiro, Itoh Taihei, Izumiyama Kei, Shibutani Shuji, Hanada Kenji, Yokoyama Hiroaki, Yamamoto Yuko, Yokota Takashi, Tomita Hirofumi, Magota Koji, Okumura Ken

JOURNAL OF HYPERTENSION   30 ( 4 )   778 - 786   2012年04月

Coronary vasospasm induced in transgenic mouse with increased phospholipase C-δ1 activity.

Shuji Shibutani, Tomohiro Osanai, Toshihiro Ashitate, Shigeki Sagara, Kei Izumiyama, Yuko Yamamoto, Kenji Hanada, Takashi Echizen, Hirofumi Tomita, Takeshi Fujita, Takeshi Miwa, Hiroaki Matsubara, Yoshimi Homma, Ken Okumura

Circulation   125 ( 8 )   1027 - 1036   2012年02月

Coronary Vasospasm Induced in Transgenic Mouse With Increased Phospholipase C-delta 1 Activity

Shibutani Shuji, Osanai Tomohiro, Ashitate Toshihiro, Sagara Shigeki, Izumiyama Kei, Yamamoto Yuko, Hanada Kenji, Echizen Takashi, Tomita Hirofumi, Fujita Takeshi, Miwa Takeshi, Matsubara Hiroaki, Homma Yoshimi, Okumura Ken

CIRCULATION   125 ( 8 )   1027 - 1036   2012年02月

Randomized study on the efficacy and safety of landiolol, an ultra-short-acting β1-adrenergic blocker, in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention

Hanada Kenji, Higuma Takumi, Nishizaki Fumie, Sukekawa Takanori, Yokota Takashi, Yamada Masahiro, Saito Shin, Kushibiki Motoi, Oikawa Koichi, Abe Naoki, Tomita Hirofumi, Osanai Tomohiro, Okumura Ken

日本循環器學誌   76 ( 2 )   439 - 445   2012年

Overexpression of Coupling Factor 6 Attenuates Exercise-Induced Physiological Cardiac Hypertrophy By Inhibiting Pi3k/akt Signaling in Mice

Sagara Shigeki, Osanai Tomihiro, Suzuki Akiko, Nishizaki Fumie, Sukekawa Takanori, Itoh Taihei, Izumiyama Kei, Shibutani Shuji, Hanada Kenji, Yamamoto Yuko, Yokoyama Hiroaki, Yokota Takashi, Tomita Hirofumi, Okumura Ken

CIRCULATION   124 ( 21 )   2011年11月

Inhibition of P38 MAP Kinase Attenuates Left Ventricular Hypertrophy and Inhibits Progression of Systolic Dysfunction on Pressure-Overload Induced Pathological Cardiac Hypertrophy in Mice

Hanada Kenji, Osanai Tomohiro, Sukekawa Takanori, Ohya Fumie, Izumiyama Kei, Sagara Shigeki, Ito Taihei, Yamamoto Yuko, Shibutani Shuji, Tomita Hirofumi, Okumura Ken

弘前醫學   62 ( 1 )   18 - 26   2011年04月

Mutation Analysis ABCC9 Gene in Japanese Patients with Coronary Spastic Angina

Shibutani Shuji, Osanai Tomohiro, Oya Humie, Sagara Shigeki, Izumiyama Kei, Yamamoto Yuko, Hanada Kenji, Tomita Hirofumi, Okumura Ken

弘前醫學   62 ( 1 )   27 - 33   2011年04月

p38 MAP kinase の抑制はマウスの圧負荷による病的心肥大を軽減し心機能低下を抑制する

花田 賢二, 長内 智宏, 祐川 誉徳, 大矢 史恵, 泉山 圭, 相樂 繁樹, 伊藤 太平, 山本 祐子, 渋谷 修司, 富田 泰史, 奥村 謙

弘前医学   62 ( 1 )   18 - 26   2011年

日本人冠攣縮性狭心症患者における ABCC9遺伝子変異の有無の解析

渋谷 修司, 長内 智宏, 大矢 史恵, 相樂 繁樹, 泉山 圭, 山本 祐子, 花田 賢二, 富田 泰史, 奥村 謙

弘前医学   62 ( 1 )   27 - 33   2011年

Overexpression of Coupling Factor 6 Attenuates Physiological Cardiac Hypertrophy Induced by Swimming and Causes Systolic Cardiac Dysfunction in Mice

Sagara Shigeki, Osanai Tomohiro, Itoh Taihei, Izumiyama Kei, Shibutani Shuji, Hanada Kenji, Yamamoto Yuko, Okumura Ken

CIRCULATION   122 ( 21 )   2010年11月

Overexpression of Coupling Factor 6 Causes Salt-Sensitive Hypertension and Systolic Cardiac Dysfunction: Gender as an Important Modulator

Izumiyama Kei, Osanai Tomohiro, Ashitate Toshihiro, Sagara Shigeki, Itoh Taihei, Shibutani Shuji, Hanada Kenji, Yamamoto Yuko, Okumura Ken

CIRCULATION   122 ( 21 )   2010年11月

Overexpression of coupling factor 6 causes cardiac dysfunction under high-salt diet in mice.

Toshihiro Ashitate, Tomohiro Osanai, Makoto Tanaka, Koji Magota, Takashi Echizen, Kei Izumiyama, Hiroaki Yokoyama, Shuji Shibutani, Kenji Hanada, Hirofumi Tomita, Ken Okumura

Journal of hypertension   28 ( 11 )   2243 - 2251   2010年11月

Effects of telmisartan on markers of ventricular remodeling in patients with acute myocardial infarction: comparison with enalapril.

Takashi Yokota, Tomohiro Osanai, Kenji Hanada, Motoi Kushibiki, Naoki Abe, Koichi Oikawa, Hirofumi Tomita, Takumi Higuma, Jin Yokoyama, Hiroyuki Hanada, Ken Okumura

Heart and vessels   25 ( 6 )   460 - 468   2010年11月

Effects of telmisartan on markers of ventricular remodeling in patients with acute myocardial infarction: comparison with enalapril

Yokota Takashi, Osanai Tomohiro, Hanada Kenji, Kushibiki Motoi, Abe Naoki, Oikawa Koichi, Tomita Hirofumi, Higuma Takumi, Yokoyama Jin, Hanada Hiroyuki, Okumura Ken

HEART AND VESSELS   25 ( 6 )   460 - 468   2010年11月

Overexpression of coupling factor 6 causes cardiac dysfunction under high-salt diet in mice

Ashitate Toshihiro, Osanai Tomohiro, Tanaka Makoto, Magota Koji, Echizen Takashi, Izumiyama Kei, Yokoyama Hiroaki, Shibutani Shuji, Hanada Kenji, Tomita Hirofumi, Okumura Ken

JOURNAL OF HYPERTENSION   28 ( 11 )   2243 - 2251   2010年11月

OE-070 Plasma Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-1 Level at Admission can Predict In-hospital Prognosis in Patients with Acute Myocardial Infarction(OE12,ACS/AMI (Clinical/Pathophysiology) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Higuma Takumi, Hanada Kenji, Abe Naoki, Oikawa Koichi, Kushibiki Motoi, Yokota Takashi, Yamamoto Yuko, Ohya Fumie, Hanada Hiroyuki, Osanai Tomohiro, Kume Noriaki, Okumura Ken

Circulation journal : official journal of the Japanese Circulation Society   73 ( 0 )   191   2009年03月

OJ-186 Efficacy and Safety of Landiolol, an Ultra Short-acting, β 1-selective Adrenergic Blocker, in Patients with Acute Myocardial Infarction Undergoing PCI(OJ31,ACS/AMI (Clinical/Treatment) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Hanada Kenji, Abe Naoki, Ohya Fumie, Sekiguchi Yuko, Yokota Takashi, Kushibiki Motoi, Oikawa Koichi, Higuma Takumi, Hanada Hiroyuki, Osanai Tomohiro, Okumura Ken

Circulation journal : official journal of the Japanese Circulation Society   73 ( 0 )   332 - 333   2009年03月

アミオダロンのマトリックスメタロプロテイナーゼ-2 活性に対する作用：ラット心筋梗塞モデルでの検討

堀内 大輔, 長内 智宏, 越前 崇, 芦立 俊宗, 加藤 千里, 横山 公章, 花田 賢二, 澁谷 修司, 伊藤 太平, 奥村 謙

弘前医学   60 ( 1-4 )   45 - 53   2009年

低酸素による心筋細胞 Insulin-like growth factor-1 遺伝子発現亢進の役割：心保護作用の機序について

加藤 千里, 長内 智宏, 渋谷 修司, 花田 賢二, 奥村 謙

弘前医学   60 ( 1-4 )   36 - 44   2009年

20)高度房室ブロックならびに流出路圧較差を生じたたこつぼ型心筋障害の一例(第144回日本循環器学会東北地方会)

相楽 繁樹, 樋熊 拓未, 花田 賢二, 澁谷 修司, 横田 貴志, 藤原 崇之, 阿部 直樹, 及川 広一, 富田 泰史, 木村 正臣, 佐々木 真吾, 横山 仁, 花田 裕之, 長内 智宏, 奥村 謙

71 ( 0 )   984   2007年10月

43)高齢のFallot修復術後に出現した左心不全に対し心臓再同期療法が有効であった1例(第143回日本循環器学会東北地方会)

渋谷 修司, 佐々木 真吾, 花田 賢二, 横田 貴志, 及川 広一, 阿部 直樹, 富田 泰史, 木村 正臣, 樋熊 拓未, 横山 仁, 花田 裕之, 長内 智宏, 奥村 謙

71 ( 0 )   930   2007年10月

21)心房梗塞によりアトロピン無効の徐脈低血圧をきたした1例(第143回日本循環器学会東北地方会)

花田 賢二, 樋熊 拓未, 渋谷 修司, 横田 貴志, 及川 広一, 阿部 直樹, 富田 泰史, 木村 正臣, 佐々木 真吾, 横山 仁, 花田 裕之, 長内 智宏, 奥村 謙

71 ( 0 )   927   2007年10月

Novel ferrochelatase mutations in Japanese patients with erythropoietic protoporphyria: High frequency of the splice site modulator IVS3-48C polymorphism in the Japanese population

Nakano Hajime, Nakano Aoi, Toyomaki Yuka, Ohashi Shigeki, Harada Ken, Moritsugu Ryuta, Takeda Hitoshi, Kawada Akira, Mitsuhashi Yoshihiko, Hanada Katsumi

JOURNAL OF INVESTIGATIVE DERMATOLOGY   126 ( 12 )   2717 - 2719   2006年12月

2022年度，循環器内科学・外科学Ⅱ，専門教育科目（学部）

2019年度，6年　クリニカルクラークシップ，専門教育科目（学部）

2019年度，BSL，専門教育科目（学部）

2019年度，プレBSL，専門教育科目（学部）

2018年度，5年　臨床実習，専門教育科目（学部）

2018年度，6年　クリニカルクラークシップ，専門教育科目（学部）

2017年度，5年　臨床実習，専門教育科目（学部）

2017年度，6年　クリニカルクラークシップ，専門教育科目（学部）

2016年度，5年　臨床実習，専門教育科目（学部）

2016年度，6年　クリニカルクラークシップ，専門教育科目（学部）

2013年度，5年　臨床実習，専門教育科目（学部）

2013年度，6年　クリニカルクラークシップ，専門教育科目（学部）