Long-term efficacy and tolerability of dose-adjusted thiopurine treatment in maintaining remission in inflammatory bowel disease patients with NUDT15 heterozygosity.

Maeda T, Sakuraba H, Hiraga H, Yoshida S, Kakuta Y, Kikuchi H, Kawaguchi S, Hasui K, Tatsuta T, Chinda D, Mikami T, Fukuda S

Intestinal research   2021年01月

Tryptanthrin suppresses double-stranded RNA-induced CXCL10 expression via inhibiting the phosphorylation of STAT1 in human umbilical vein endothelial cells.

Kawaguchi S, Sakuraba H, Kikuchi H, Numao N, Asari T, Hiraga H, Ding J, Matsumiya T, Seya K, Fukuda S, Imaizumi T

Molecular immunology   129   32 - 38   2021年01月

Cyclosporine protects from intestinal epithelial injury by modulating butyrate uptake via upregulation of membrane monocarboxylate transporter 1 levels.

12. Ota S, Sakuraba H, Hiraga H, Yoshida S, Satake M, Akemoto Y, Tanaka N, Watanabe R, Maeda T, Murai Y, Ueno K, Niioka T, Hayakari M, Ishiguro Y, Fukuda S

Biochem Biophys Rep.   2020年12月

Cyclosporine protects from intestinal epithelial injury by modulating butyrate uptake via upregulation of membrane monocarboxylate transporter 1 levels.

Ota S, Sakuraba H, Hiraga H, Yoshida S, Satake M, Akemoto Y, Tanaka N, Watanabe R, Takato M, Murai Y, Ueno K, Niioka T, Hayakari M, Ishiguro Y, Fukuda S

Biochemistry and biophysics reports   24   100811   2020年12月

Usefulness of serum opsonic activity measured by chemiluminescence method to assess the invasiveness of colorectal endoscopic mucosal dissection.

Chinda D, Shimoyama T, Arai T, Sawada K, Akitaya K, Kudo S, Yasuda K, Miyazawa K, Akimoto N, Sato S, Hayamizu S, Tatsuta T, Kikuchi H, Hiraga H, Sawaya M, Sakuraba H, Mikami T, Nakaji S, Fukuda S

Free radical research   54 ( 11-12 )   810 - 817   2020年12月

Case report of lanthanum deposition in the esophagus.

Tatsuta T, Mikami T, Chinda D, Akitaya K, Igarashi S, Hasui K, Kikuchi H, Hiraga H, Sawaya M, Sakuraba H, Shimoyama T, Haga T, Kijima H, Fukuda S

Clinical journal of gastroenterology   13 ( 5 )   683 - 687   2020年10月

Melanoma Differentiation-Associated Gene 5 Positively Modulates TNF-α-Induced CXCL10 Expression in Cultured HuH-7 and HLE Cells.

Shogo Kawaguchi, Hirotake Sakuraba, Toshihiro Haga, Tomoh Matsumiya, Kazuhiko Seya, Tetsu Endo, Naoya Sawada, Chikara Iino, Hidezumi Kikuchi, Hiroto Hiraga, Shinsaku Fukuda, Tadaatsu Imaizumi

Inflammation   42 ( 6 )   2095 - 2104   2019年12月

Diagnostic approach for patients with unidentified fever according to the classical criteria of fever of unknown origin in the field of autoimmune disorders.

Rina Watanabe, Hirotake Sakuraba, Hiroto Hiraga, Dai Kishida, Shinji Ota, Keisuke Hasui, Hidezumi Kikuchi, Yui Akemoto, Nahoko Tanaka, Takato Maeda, Yasuhisa Murai, Shukuko Yoshida, Tetsuya Tatsuta, Manabu Sawaya, Daisuke Chinda, Tatsuya Mikami, Yoh Ishiguro, Shinsaku Fukuda

Immunological medicine   42 ( 4 )   176 - 184   2019年12月

Diagnostic approach for patients with unidentified fever according to the classical criteria of fever of unknown origin in the field of autoimmune disorders.

Watanabe R, Sakuraba H, Hiraga H, Kishida D, Ota S, Hasui K, Kikuchi H, Akemoto Y, Tanaka N, Maeda T, Murai Y, Yoshida S, Tatsuta T, Sawaya M, Chinda D, Mikami T, Ishiguro Y, Fukuda S

Immunological medicine   42 ( 4 )   176 - 184   2019年12月

Melanoma Differentiation-Associated Gene 5 Positively Modulates TNF-α-Induced CXCL10 Expression in Cultured HuH-7 and HLE Cells.

Kawaguchi S, Sakuraba H, Haga T, Matsumiya T, Seya K, Endo T, Sawada N, Iino C, Kikuchi H, Hiraga H, Fukuda S, Imaizumi T

Inflammation   42 ( 6 )   2095 - 2104   2019年12月

Long-term maintenance of the mucosal healing induced by azacitidine therapy in a patient with intestinal Behçet's-like disease accompanied with myelodysplastic syndrome involving trisomy 8.

Nahoko Tanaka, Hirotake Sakuraba, Hiroto Hiraga, Ko Mayama, Hidezumi Kikuchi, Dai Kishida, Yui Akemoto, Keisuke Hasui, Shinji Ota, Rina Watanabe, Yasuhisa Murai, Takato Maeda, Kosuke Kamata, Tetsuya Tatsuta, Manabu Sawaya, Daisuke Chinda, Tatsuya Mikami, Kazufumi Yamagata, Yoh Ishiguro, Masanori Tanaka, Shinsaku Fukuda

Immunological medicine   42 ( 3 )   135 - 141   2019年09月

A case of celiac disease with type I enteropathy-associated T-cell lymphoma in a Japanese male patient.

Hiroto Hiraga, Hirotake Sakuraba, Nahoko Tanaka, Rina Watanabe, Yui Akemoto, Shinji Ota, Hidezumi Kikuchi, Manabu Sawaya, Noriko Hiraga, Daisuke Chinda, Norihiro Hanabata, Tatsuya Mikami, Tadashi Shimoyama, Takenori Takahata, Masanori Tanaka, Shinsaku Fukuda

Immunological medicine   42 ( 3 )   142 - 147   2019年09月

A case of celiac disease with type I enteropathy-associated T-cell lymphoma in a Japanese male patient.

Hiraga H, Sakuraba H, Tanaka N, Watanabe R, Akemoto Y, Ota S, Kikuchi H, Sawaya M, Hiraga N, Chinda D, Hanabata N, Mikami T, Shimoyama T, Takahata T, Tanaka M, Fukuda S

Immunological medicine   42 ( 3 )   142 - 147   2019年09月

Long-term maintenance of the mucosal healing induced by azacitidine therapy in a patient with intestinal Behçet's-like disease accompanied with myelodysplastic syndrome involving trisomy 8.

Tanaka N, Sakuraba H, Hiraga H, Mayama K, Kikuchi H, Kishida D, Akemoto Y, Hasui K, Ota S, Watanabe R, Murai Y, Maeda T, Kamata K, Tatsuta T, Sawaya M, Chinda D, Mikami T, Yamagata K, Ishiguro Y, Tanaka M, Fukuda S

Immunological medicine   42 ( 3 )   135 - 141   2019年09月

Successful adalimumab treatment and usefulness of capsule endoscopy for gut inflammation concomitant with ankylosing spondylitis.

Ota S, Sakuraba H, Hiraga H, Hasui K, Satake M, Hanabata N, Akemoto Y, Watanabe R, Tanaka N, Ishiguro Y, Tanaka M, Fukuda S

Modern rheumatology   29 ( 4 )   708 - 713   2019年07月

A case of nivolumab-associated colitis, which relapsed after mucosal healing and was then successfully treated with mesalazine.

Hidezumi Kikuchi, Hirotake Sakuraba, Yui Akemoto, Yasuhisa Murai, Yukari Fukutoku, Taka Asari, Tetsuya Tatsuta, Keisuke Hasui, Hiroto Hiraga, Manabu Sawaya, Daisuke Chinda, Tatsuya Mikami, Masanori Tanaka, Shinsaku Fukuda

Immunological medicine   42 ( 1 )   39 - 44   2019年03月

A case of nivolumab-associated colitis, which relapsed after mucosal healing and was then successfully treated with mesalazine.

Kikuchi H, Sakuraba H, Akemoto Y, Murai Y, Fukutoku Y, Asari T, Tatsuta T, Hasui K, Hiraga H, Sawaya M, Chinda D, Mikami T, Tanaka M, Fukuda S

Immunological medicine   42 ( 1 )   39 - 44   2019年03月

Gastric Focal Neutrophil Infiltration and Wide Duodenal Gastric Foveolar Metaplasia Are Histologic Discriminative Markers for Crohn's Disease and Behçet's Disease.

Yui Akemoto, Hirotake Sakuraba, Masanori Tanaka, Hiroto Hiraga, Hidezumi Kikuchi, Satoko Morohashi, Shinji Ota, Keisuke Hasui, Miwa Satake, Rina Watanabe, Nahoko Tanaka, Shogo Kawaguchi, Tetsuya Tatsuta, Manabu Sawaya, Daisuke Chinda, Tatsuya Mikami, Yoh Ishiguro, Hiroshi Kijima, Shinsaku Fukuda

Digestion   100 ( 3 )   210 - 219   2019年

Gastric Focal Neutrophil Infiltration and Wide Duodenal Gastric Foveolar Metaplasia Are Histologic Discriminative Markers for Crohn's Disease and Behçet's Disease.

Akemoto Y, Sakuraba H, Tanaka M, Hiraga H, Kikuchi H, Morohashi S, Ota S, Hasui K, Satake M, Watanabe R, Tanaka N, Kawaguchi S, Tatsuta T, Sawaya M, Chinda D, Mikami T, Ishiguro Y, Kijima H, Fukuda S

Digestion   100 ( 3 )   210 - 219   2019年

大腸カプセル内視鏡による全腸観察を利用したNSAIDs起因性腸病変評価の有用性

平賀 寛人, 澤谷 学, 平賀 典子, 珍田 大輔, 三上 達也, 海老名 麻美, 福田 眞作, 櫻庭 裕丈, 有明 千鶴, 前田 高人, 村井 康久, 渡邊 里奈, 立田 哲也, 蓮井 桂介, 菊池 英純

日本小腸学会学術集会プログラム・抄録集   3 ( 0 )   41_2 - 41_2   2019年

免疫チェックポイント阻害剤投与後に発症した小腸炎の3例

菊池 英純, 三上 達也, 福田 眞作, 櫻庭 裕丈, 明本 由衣, 浅利 享, 蓮井 桂介, 立田 哲也, 平賀 寛人, 澤谷 学, 珍田 大輔

日本小腸学会学術集会プログラム・抄録集   3 ( 0 )   43_1 - 43_1   2019年

クローン病小腸病変のMRI拡散強調画像による炎症線維化バランス評価の有用性

蓮井 桂介, 樋口 直樹, 有明 千鶴, 立田 哲也, 澤谷 学, 珍田 大輔, 三上 達也, 石黒 陽, 田中 正則, 福田 眞作, 櫻庭 裕丈, 平賀 寛人, 菊池 英純, 明本 由衣, 浅利 享, 渡邊 里奈, 前田 高人, 星 健太郎

日本小腸学会学術集会プログラム・抄録集   3 ( 0 )   63_1 - 63_1   2019年

Vitamin a Deficiency Impairs Host Resistance to Listeria Monocytogenes Infection Through Excessive Apoptosis of macrophages

Tanaka Nahoko, Hiraga Hiroto, Sakuraba Hirotake, Murai Yasuhisa, Maeda Takato, Watanabe Rina, Ota Shinji, Akemoto Yui, Hasui Keisuke, Yoshida Shukuko, Asano Krisana, Nakane Akio, Fukuda Shinsaku

弘前医学   69 ( 1 )   163 - 171   2019年

Influence of gastric endoscopic submucosal dissection on serum opsonic activity measured by chemiluminescence

Arai Tetsu, Tatsuta Tetsuya, Kikuchi Hidezumi, Hiraga Hiroto, Sawaya Manabu, Sakuraba Hirotake, Mikami Tatsuya, Nakaji Shigeyuki, Fukuda Shinsaku, Chinda Daisuke, Shimoyama Tadashi, Sawada Kaori, Akitaya Kazuki, Miyazawa Kuniaki, Akimoto Naoki, Sato Satoshi, Hayamizu Shiro

Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ   64 ( 2 )   180 - 185   2019年

Successful treatment with tacrolimus of refractory pyoderma gangrenosum with pouchitis after restorative proctocolectomy for ulcerative colitis.

Satake M, Sakuraba H, Hiraga H, Tarakita N, Akemoto Y, Ota S, Hasui K, Nishiya D, Hayamizu S, Kikuchi H, Sawaya M, Chinda D, Mikami T, Shimoyama T, Fukuda S

Immunological medicine   41 ( 3 )   142 - 146   2018年09月

Estimation of perioperative invasiveness of colorectal endoscopic submucosal dissection evaluated by energy metabolism

Chinda Daisuke, Kawaguchi Shogo, Kikuchi Hidezumi, Hiraga Hiroto, Sawaya Manabu, Sakuraba Hirotake, Mikami Tatsuya, Fukuda Shinsaku, Shimoyama Tadashi, Miyazawa Kuniaki, Arai Tetsu, Hayamizu Shiro, Yanagimachi Miyuki, Tsukamoto Toshiaki, Akitaya Kazuki, Tatsuta Tetsuya

Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ   63 ( 2 )   164 - 167   2018年

Prediction of maintained mucosal healing in patients with Crohn's disease under treatment with infliximab using diffusion-weighted magnetic resonance imaging.

Sakuraba H, Ishiguro Y, Hasui K, Hiraga H, Fukuda S, Shibutani K, Takai Y

Digestion   89 ( 1 )   49 - 54   2014年

関節リウマチ患者に対する生物学的製剤による治療は臨床的寛解時における MRI で検出される潜在的関節炎を抑制する

蓮井 桂介, 櫻庭 裕丈, 石黒 陽, 平賀 寛人, 福田 眞作

弘前医学   64 ( 2 )   119 - 126   2014年

症例報告 術前画像診断にてIPMN由来浸潤癌と診断した漿液性嚢胞腺腫の1例

平賀 寛人, 澤田 直也, 相原 智之

胆膵の病態生理   27 ( 1 )   59 - 61   2011年06月

Cyclosporine regulates intestinal epithelial apoptosis via TGF-beta-related signaling.

Yuki Satoh, Yoh Ishiguro, Hirotake Sakuraba, Shogo Kawaguchi, Hiroto Hiraga, Shinsaku Fukuda, Akio Nakane

American journal of physiology. Gastrointestinal and liver physiology   297 ( 3 )   G514 - G519   2009年09月

Cyclosporine regulates intestinal epithelial apoptosis via TGF-beta-related signaling.

Satoh Y, Ishiguro Y, Sakuraba H, Kawaguchi S, Hiraga H, Fukuda S, Nakane A

American journal of physiology. Gastrointestinal and liver physiology   297 ( 3 )   G514 - 9   2009年09月

治療抵抗性潰瘍性大腸炎におけるTransforming growth factor-β受容体の発現抑制

島谷 孝司, 石黒 陽, 川口 章吾, 佐藤 裕紀, 平賀 寛人, 山口 佐都子, 櫻庭 裕丈, 藤田 均, 山形 和史, 福田 眞作

弘前医学   59 ( 2 )   90 - 97   2008年

All-trans-retinoic acid (atRA) increases host resistance to Listeria monocytogenes infection

Hiraga Hiroto, Sashinami Hiroshi, Hu Dong-Liang, Ishiguro Yoh, Wakabayashi Koichi, Munakata Akihiro, Nakane Akio

弘前医学   59 ( 0 )   S244 - 252   2007年

日本と中国における急性胃腸炎起因微生物の汚染調査

胡 東良, 銭 愛東, 単 暁風, 成田 浩司, 差波 拓志, 長内 理大, 阿部 由紀子, 平賀 寛人, 工藤 幸清, 劉 勇, 中根 明夫

弘前医学   59 ( 1 )   1 - 6   2007年

Macrophage migration inhibitory factor has a proinflammatory activity via the p38 pathway in glucocorticoid-resistant ulcerative colitis.

Ishiguro Y, Ohkawara T, Sakuraba H, Yamagata K, Hiraga H, Yamaguchi S, Fukuda S, Munakata A, Nakane A, Nishihira J

Clinical immunology (Orlando, Fla.)   120 ( 3 )   335 - 41   2006年09月

[Successful treatment of 5-FU intraarterial infusion on the third postoperative day for a patient with multiple liver metastases from colon cancer and high risk of liver failure].

Mori T, Munakata M, Kasai M, Nozaki T, Kawamura S, Sawamura N, Hiraga H, Sakata Y

Gan to kagaku ryoho. Cancer & chemotherapy   31 ( 7 )   1101 - 3   2004年07月

2017年度年度，臨床免疫学，専門教育科目（学部）

2012年度年度，BSL臨床実習，専門教育科目（学部）

2012年度年度，OSCE，専門教育科目（学部）

2012年度年度，PreBSL，専門教育科目（学部）