Affiliation
A C
NAGAOSA Kaz
Degree
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博士（薬学）
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修士（薬学）
Research Interests
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phagocytosis
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生体防御
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apoptosis
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host defence
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cancer prevention
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cancer prevention
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phagocytosis
Research Areas
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Life Science / Food sciences
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Life Science / Pharmaceutical hygiene and biochemistry
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Life Science / Urology
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Life Science / Functional biochemistry
Professional Memberships
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The Japanese Biochemical Society
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Japanese Association for Cancer Prevention
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The Pharmaceutical Society of Japan
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The Japan Society for Bioscience, Biotechnology, and Agrochemistry
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The Japanese Society of Developmental Biologists
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日本薬学会
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日本発生生物学会
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日本生化学会
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The Pharmaceutical Society of Japan
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The Japanese Society of Developmental Biologists
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The Japanese Biochemical Society
Papers
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Promotion of Export and Market Evaluation of Salmon Trout from Aomori Prefecture, Japan
FUKUDA Satoru, SUZUKI Kosuke, IZUMI Hikari, MAEDA Yutaka, NAGAOSA Kaz, NAKAI Yuji, MAEDA Hayato, OKAMURA Koichi, SAGA Naotsune
Journal of the Japan Society for Intellectual Production 17 ( 2 ) 113 - 125 2021.6
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Using Drosophila to study the mechanisms of cancer development and prevention
Nagaosa K, Shiratsuchi A
Journal of Center for Medical Education Sapporo Medical University 12 9 - 16 2021.3
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Role for phagocytosis in the prevention of neoplastic transformation in Drosophila
Min Zhang, Kaz Nagaosa, Yuji Nakai, Tetsuo Yasugi, Masako Kushihiki, Dini Rahmatika, Makoto Sato, Akiko Shiratsuchi, Yoshinobu Nakanishi
Genes to Cells 25 ( 10 ) 675 - 684 2020.10
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Inhibitory effects of viral infection on cancer development.
Rahmatika, D., Kuroda, N., Min, Z., Nainu, F., Nagaosa, K., Nakanishi, Y.
Virology 528 48 - 53 2019.2
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ショウジョウバエを用いた食品の機能性研究
永長 一茂, 中井 雄治
日本家政学会誌 70 ( 11 ) 770 - 777 2019
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Oral Administration of Edible Wakame Seaweed Undaria pinnatifida (Wakame) Modifies Glucose and Lipid Metabolism in Rats: A DNA Microarray Analysis.
Yoshinaga, K., Nakai, Y., Izumi, H., Nagaosa, K., Ishijima, T., Nakano, T., Abe, K.
Molecular Nutrition & Food Research 2018.4
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Signaling pathway for phagocyte priming upon encounter with apoptotic cells.
Nonaka, S., Ando, Y., Kanetani, T., Hoshi, C., Nakai, Y., Nainu, F., Nagaosa, K., Shiratsuchi, A., and Nakanishi, Y.
Journal of Biological Chemistry 292 ( 19 ) 8059 - 8072 2017.5
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Peptidoglycan recognition protein-triggered induction of Escherichia coli gene in Drosophila melanogaster.
Qingquan Kong, Yuji Nakai, Nanae Kuroda, Akiko Shiratsuchi, Kaz Nagaosa, Yoshinobu Nakanishi
Journal of biochemistry 157 ( 6 ) 507 - 517 2015.6
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Phosphatidylserine recognition and induction of apoptotic cell clearance by Drosophila engulfment receptor Draper.
Tran Thanh Tung, Kaz Nagaosa, Yu Fujita, Asana Kita, Hiroki Mori, Ryo Okada, Saori Nonaka, Yoshinobu Nakanishi
Journal of biochemistry 153 ( 5 ) 483 - 491 2013.5
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Integrin αPS3/βν-mediated phagocytosis of apoptotic cells and bacteria in Drosophila.
Saori Nonaka, Kaz Nagaosa, Toshinobu Mori, Akiko Shiratsuchi, Yoshinobu Nakanishi
The Journal of biological chemistry 288 ( 15 ) 10374 - 10380 2013.4
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Role of NPxY motif in Draper-mediated apoptotic cell clearance in Drosophila.
Yu Fujita, Kaz Nagaosa, Akiko Shiratsuchi, Yoshinobu Nakanishi
Drug discoveries & therapeutics 6 ( 6 ) 291 - 297 2012.12
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Independent recognition of Staphylococcus aureus by two receptors for phagocytosis in Drosophila.
Akiko Shiratsuchi, Toshinobu Mori, Kenji Sakurai, Kaz Nagaosa, Kazuhisa Sekimizu, Bok Luel Lee, Yoshinobu Nakanishi
The Journal of biological chemistry 287 ( 26 ) 21663 - 21672 2012.6
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Apoptosis-dependent externalization and involvement in apoptotic cell clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila.
Ryo Okada, Kaz Nagaosa, Takayuki Kuraishi, Hiroshi Nakayama, Naoko Yamamoto, Yukiko Nakagawa, Naoshi Dohmae, Akiko Shiratsuchi, Yoshinobu Nakanishi
The Journal of biological chemistry 287 ( 5 ) 3138 - 3146 2012.1
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Integrin βν-mediated phagocytosis of apoptotic cells in Drosophila embryos.
Kaz Nagaosa, Ryo Okada, Saori Nonaka, Kazuki Takeuchi, Yu Fujita, Tomoyuki Miyasaka, Junko Manaka, István Ando, Yoshinobu Nakanishi
The Journal of biological chemistry 286 ( 29 ) 25770 - 25777 2011.7
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Phagocytic removal of cells that have become unwanted: Implications for animal development and tissue homeostasis
Yoshinobu Nakanishi, Kaz Nagaosa, Akiko Shiratsuchi
DEVELOPMENT GROWTH & DIFFERENTIATION 53 ( 2 ) 149 - 160 2011.2
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Role of NPxY motif in Draper-mediated apoptotic cell clearance in Drosophila
Yu Fujita, Kaz Nagaosa, Akiko Shiratsuchi, Yoshinobu Nakanishi
Drug Discoveries & Therapeutics 6 ( 6 ) 291 - 297 2011
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ショウジョウバエ胚におけるアポトーシス細胞貪食の検出
白土明子, 永長一茂, 中西義信
実験医学（別冊）「細胞死実験プロトコール」 169 - 174 2011
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Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells.
Takayuki Kuraishi, Yukiko Nakagawa, Kaz Nagaosa, Yumi Hashimoto, Takashi Ishimoto, Takeshi Moki, Yu Fujita, Hiroshi Nakayama, Naoshi Dohmae, Akiko Shiratsuchi, Naoko Yamamoto, Koichi Ueda, Masamitsu Yamaguchi, Takeshi Awasaki, Yoshinobu Nakanishi
The EMBO journal 28 ( 24 ) 3868 - 3878 2009.12
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Immune response to bacteria in seminiferous epithelium.
Kaz Nagaosa, Chie Nakashima, Atsushi Kishimoto, Yoshinobu Nakanishi
Reproduction (Cambridge, England) 137 ( 5 ) 879 - 888 2009.5
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Activator protein 1-mediated expression of monocyte chemoattractant protein 1 in cultured rat luteal cells.
Kaz Nagaosa, Izumi Aikoshi, Yuzuru Hasegawa, Yoshinobu Nakanishi
Molecular reproduction and development 75 ( 6 ) 1077 - 1084 2008.6
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Activator protein 1-mediated expression of monocyte chemoattractant protein 1 in cultured rat luteal cells
Kaz Nagaosa, Izumi Aikoshi, Yuzuru Hasegawa, Yoshinobu Nakanishi
MOLECULAR REPRODUCTION AND DEVELOPMENT 75 ( 6 ) 1077 - 1084 2008.6
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Perturbation of spermatogenesis by androgen antagonists directly injected into seminiferous tubules of live mice.
Kaz Nagaosa, Atsushi Kishimoto, Ryoichi Kizu, Akihisa Nakagawa, Akiko Shiratsuchi, Yoshinobu Nakanishi
Reproduction (Cambridge, England) 133 ( 1 ) 21 - 27 2007.1
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Perturbation of spermatogenesis by androgen antagonists directly injected into seminiferous tubules of live mice
Kaz Nagaosa, Atsushi Kishimoto, Ryoichi Kizu, Akihisa Nakagawa, Akiko Shiratsuchi, Yoshinobu Nakanishi
REPRODUCTION 133 ( 1 ) 21 - 27 2007.1
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Phosphatidylserine- and integrin-mediated phagocytosis of apoptotic luteal cells by macrophages of the rat.
Shinya Kato, Akiko Shiratsuchi, Kaz Nagaosa, Yoshinobu Nakanishi
Development, growth & differentiation 47 ( 3 ) 153 - 161 2005.4
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Phosphatidylserine- and integrin-mediated phagocytosis of apoptotic luteal cells by macrophages of the rat
S Kato, A Shiratsuchi, K Nagaosa, Y Nakanishi
DEVELOPMENT GROWTH & DIFFERENTIATION 47 ( 3 ) 153 - 161 2005.4
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Expression and function of class B scavenger receptor type I on both apical and basolateral sides of the plasma membrane of polarized testicular Sertoli cells of the rat.
Akihisa Nakagawa, Kaz Nagaosa, Tomoe Hirose, Kayoko Tsuda, Kunio Hasegawa, Akiko Shiratsuchi, Yoshinobu Nakanishi
Development, growth & differentiation 46 ( 3 ) 283 - 298 2004.6
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Expression and function of class B scavenger receptor type I on both apical and basolateral sides of the plasma membrane of polarized testicular Sertoli cells of the rat
A Nakagawa, K Nagaosa, T Hirose, K Tsuda, K Hasegawa, A Shiratsuchi, Y Nakanishi
DEVELOPMENT GROWTH & DIFFERENTIATION 46 ( 3 ) 283 - 298 2004.6
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Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils.
S Courtney Frasch, Peter M Henson, Kaz Nagaosa, Michael B Fessler, Niels Borregaard, Donna L Bratton
The Journal of biological chemistry 279 ( 17 ) 17625 - 17633 2004.4
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Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils
SC Frasch, PM Henson, K Nagaosa, MB Fessler, N Borregaard, DL Bratton
JOURNAL OF BIOLOGICAL CHEMISTRY 279 ( 17 ) 17625 - 17633 2004.4
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Concomitant induction of apoptosis and expression of monocyte chemoattractant protein-1 in cultured rat luteal cells by nuclear factor-kappaB and oxidative stress.
Kaz Nagaosa, Akiko Shiratsuchi, Yoshinobu Nakanishi
Development, growth & differentiation 45 ( 4 ) 351 - 359 2003.8
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Concomitant induction of apoptosis and expression of monocyte chemoattractant protein-1 in cultured rat luteal cells by nuclear factor-kappa B and oxidative stress
K Nagaosa, A Shiratsuchi, Y Nakanishi
DEVELOPMENT GROWTH & DIFFERENTIATION 45 ( 4 ) 351 - 359 2003.8
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Determination of Cell Type Specificity and Estrous Cycle Dependency of Monocyte Chemoattractant Protein-1 Expression in Corpora Lutea of Normally Cycling Rats in Relation to Apoptosis and Monocyte/Macrophage Accumulation1
Kaz Nagaosa, Akiko Shiratsuchi, Yoshinobu Nakanishi
Biology of Reproduction 67 ( 5 ) 1502 - 1508 2002.11
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Determination of cell type specificity and estrous cycle dependency of monocyte chemoattractant protein-1 expression in corpora lutea of normally cycling rats in relation to apoptosis and monocyte/macrophage accumulation.
Kaz Nagaosa, Akiko Shiratsuchi, Yoshinobu Nakanishi
Biology of reproduction 67 ( 5 ) 1502 - 1508 2002.11
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Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular sertoli cells.
Yuki Kawasaki, Akihisa Nakagawa, Kaz Nagaosa, Akiko Shiratsuchi, Yoshinobu Nakanishi
The Journal of biological chemistry 277 ( 30 ) 27559 - 27566 2002.7
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Phosphatidylserine Binding of Class B Scavenger Receptor Type I, a Phagocytosis Receptor of Testicular Sertoli Cells
Yuki Kawasaki, Akihisa Nakagawa, Kaz Nagaosa, Akiko Shiratsuchi, Yoshinobu Nakanishi
Journal of Biological Chemistry 277 ( 30 ) 27559 - 27566 2002.7
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Temperature-dependent tautomer fluorescence spectra of 3’, 4’,-benzo-2’-hydroxychalcone: direct evidence for photoenolization followed by Z→ E isomerization in the singlet manifold.
Kunihiro Tokumura, Kazushige Nagaosa, Yumi Ohta, Ryoka Matsushima
Chemical Physics Letters 295 516 - 524 1998.10
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Temperature-dependent tautomer fluorescence spectra of 3 ',4 '-benzo-2 '-hydroxychalcone: Direct evidence for photoenolization followed by Z -> E isomerization in the singlet manifold
K Tokumura, K Nagaosa, Y Ohta, R Matsushima
CHEMICAL PHYSICS LETTERS 295 ( 5-6 ) 516 - 524 1998.10
Books
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実験医学別冊 現象を見抜き検出できる！細胞死実験プロトコール
白土明子, 永長一茂, 中西義信（ Role： Contributor）
羊土社 2011
Review Papers
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Using Drosophila to study the mechanisms of cencer development and prevention.
Kaz Nagaosa, Akiko Shiratsuchi
Journal of Center for Medical Education, Sapporo Medical University ( 12 ) 9 - 16 2021.3
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ショウジョウバエを用いたカシスの細胞競合促進作用の解析
永長一茂, 櫛引雅子, 山本歩, 泉ひかり, 福田覚
がん予防学術大会プログラム・抄録集 2021 (CD-ROM) 2021
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Research of cancer-preventive foods focusing on cell competition
Kaz Nagaosa
103 2 - 3 2020.6
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ショウジョウバエを用いた食品の機能性研究
永長 一茂，中井 雄治
日本家政学会誌 2019.11
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Mechanisms and significance of phagocytic elimination of cells undergoing apoptotic death.
Nonaka, S., Shiratsuchi, A., Nagaosa, K., Nakanishi, Y.
Biological and Pharmaceutical Bulletin 40 ( 11 ) 1819 - 1827 2017.11
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新たながん予防食品を探す
永長一茂
青い森きんしん経済レポート 450 1 - 1 2016.5
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発生および生体防御における変性自己細胞の貪食の役割
永長一茂
化学と生物 53 ( 2 ) 115 - 119 2015.2
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Phagocytic removal of cells that have become unwanted: implications for animal development and tissue homeostasis.
Nakanishi, Y., Nagaosa, K., and Shiratsuchi, A.
Development, growth & differentiation 53 149 - 160 2011.2
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細菌分解後のマクロファージにアポトーシスが誘導される仕組みとその意義.
永長一茂
ファルマシア 41 900 - 901 2005.9
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Mechanism of luteolysis: Phagocytosis of apoptotic luteal cells by macrophages of the rat.
Y Nakanishi, S Kato, K Nagaosa, A Shiratsuchi
BIOLOGY OF REPRODUCTION 202 - 202 2004
Awards
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JB Award 2014
2014.10
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日本生化学会北陸支部第18回支部奨励賞
2014.05
Social Activities
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弘大学食料研第22回サイエンスカフェ
2023.08.19
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弘大学食料研第21回サイエンスカフェ
2023.03.28
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弘大学食料研第20回サイエンスカフェ
2022.08.23
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弘大学食料研第19回サイエンスカフェ
2021.12.01
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弘大学食料研第18回サイエンスカフェ
2021.03
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弘大学食料研第17回サイエンスカフェ
2020.02
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弘大学食料研第16回出張サイエンスカフェ
2019.10
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弘大学食料研第15回出張サイエンスカフェ in 函館
2019.08
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弘大学食料研第14回サイエンスカフェ
2019.07
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弘大学食料研第13回サイエンスカフェ
2019.03
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弘大学食料研第12回出張サイエンスカフェ
2018.10
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弘大学食料研第11回サイエンスカフェ
2018.06
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弘前大学食料科学研究所第10回サイエンスカフェ
2018.03
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弘前大学食料科学研究所第9回出張サイエンスカフェ
2017.10
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弘前大学食料科学研究所第8回サイエンスカフェ
2017.06
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弘前大学食料科学研究所第7回サイエンスカフェ
2017.02
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弘前大学食料科学研究所第6回出張サイエンスカフェ
2016.10
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弘前大学食料科学研究所第5回サイエンスカフェ
2016.06
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弘前大学食料科学研究所第4回サイエンスカフェ
2016.02
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弘前大学附属図書館ラウンジトーク
2015.12
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平成27年度日本農芸化学会東北支部市民フォーラム「青森から発信する食品研究」
2015.11
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弘前大学食料科学研究所第3回サイエンスカフェ
2015.10
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弘前大学食料科学研究所第2回サイエンスカフェ
2015.06
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弘前大学食料科学研究所第1回サイエンスカフェ
2015.03
Media Coverage
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りんご王国こうぎょくカレッジ
2016.02