日本結合組織学会

青森糖質研究会

日本生化学会

日本癌学会

A chondroitin sulfate chain of urinary trypsin inhibitor enhances protease inhibitory activity of the core protein

Yu Teshigahara, Ikuko Kakizaki, Wataru Hirao, Kanji Tanaka, and Ryoki Takahashi

Journal of Applied Glycoscience   2020

Hyaluronan synthesis inhibitor 4-methylumbelliferone affects extracellular matrix components in cultured human skin fibroblasts

Yasufumi Endo, Genn Takahashi, Ikuko Kakizaki, and Masahiko Endo

Hirosaki Med. J.   70 ( 1 )   1 - 12   2019.11

Dermatan sulfate oligosaccharides having reducing end 2, 5-anhydro-d-talose inhibit bovine testicular hyaluronidase activity.

Carbohydrate research   483   107754 - 107754   2019.9

Proteoglycan-substrate gel zymography for the detection of chondroitin sulfate-degrading enzymes.

Takashi Kobayashi, Ikuko Kakizaki, Toshiya Nakamura

Analytical biochemistry   568   51 - 52   2019.3

Development of new therapeutic agents of preterm birth by glycosaminoglycan

2019.3

4-Methylumbelliferone Decreases the Hyaluronan-rich Extracellular Matrix and Increases the Effectiveness of 5-Fluorouracil.

Eri Yoshida, Daisuke Kudo, Hayato Nagase, Akiko Suto, Hiroshi Shimoda, Shinichiro Suto, Ikuko Kakizaki, Masahiko Endo, Kenichi Hakamada

Anticancer research   38 ( 10 )   5799 - 5804   2018.10

Characterization of Proteoglycan and Hyaluronan in Hot Water Extract from Salmon Cartilage

Kakizaki, I., Miura, A., Mineta, T., Hong, J., and Kato, Y.

Journal of Applied Glycoscience   64 ( 4 )   83 - 90   2017.11

A mechanism for evasion of CTL immunity by altered O-glycosylation of HLA class I.

Mihoko Sutoh Yoneyama, Yuki Tobisawa, Shingo Hatakeyama, Misaki Sato, Kiyoshi Tone, Yota Tatara, Ikuko Kakizaki, Tomihisa Funyu, Minoru Fukuda, Senji Hoshi, Chikara Ohyama, Shigeru Tsuboi

Journal of biochemistry   161 ( 6 )   479 - 492   2017.6

Chondroitin sulfate proteoglycans from salmon nasal cartilage inhibit angiogenesis.

Takashi Kobayashi, Ikuko Kakizaki, Hiroyuki Nozaka, Toshiya Nakamura

Biochemistry and biophysics reports   9   72 - 78   2017.3

4-Methylumbelliferone Suppresses Hyaluronan Synthesis and Tumor Progression in SCID Mice Intra-abdominally Inoculated With Pancreatic Cancer Cells.

Hayato Nagase, Daisuke Kudo, Akiko Suto, Eri Yoshida, Shinichiro Suto, Mika Negishi, Ikuko Kakizaki, Kenichi Hakamada

Pancreas   46 ( 2 )   190 - 197   2017.2

Hyaluronan Production Regulates Metabolic and Cancer Stem-like Properties of Breast Cancer Cells via Hexosamine Biosynthetic Pathway-coupled HIF-1 Signaling.

Theerawut Chanmee, Pawared Ontong, Tomomi Izumikawa, Miho Higashide, Nobutoshi Mochizuki, Chatchadawalai Chokchaitaweesuk, Manatsanan Khansai, Kazuki Nakajima, Ikuko Kakizaki, Prachya Kongtawelert, Naoyuki Taniguchi, Naoki Itano

The Journal of biological chemistry   291 ( 46 )   24105 - 24120   2016.11

Antitumor effects of the hyaluronan inhibitor 4-methylumbelliferone on pancreatic cancer.

Eri Yoshida, Daisuke Kudo, Hayato Nagase, Hiroshi Shimoda, Shinichiro Suto, Mika Negishi, Ikuko Kakizaki, Masahiko Endo, Kenichi Hakamada

Oncology letters   12 ( 4 )   2337 - 2344   2016.10

Effects of C-xylopyranoside derivative on epithelial regeneration in an in vitro 3D oral mucosa model.

Atsushi Uenoyama, Ikuko Kakizaki, Aki Shiomi, Naoaki Saito, Yuko Hara, Taro Saito, Hisashi Ohnuki, Hiroko Kato, Ritsuo Takagi, Takeyasu Maeda, Kenji Izumi

Bioscience, biotechnology, and biochemistry   80 ( 7 )   1344 - 1355   2016.7

サケ軟骨熱水抽出物 (ヒアルコPG) の経口摂取による日焼け抑制効果―無作為化二重盲検プラセボ対照並行群間比較試験―

後藤 昌史, 末川 裕, 花田 友香子, 柿崎 育子, 山本 和司, 加藤 陽治

日本応用糖質科学会誌　応用糖質科学   6 ( 2 )   138 - 146   2016.5

Benefical effect of 4-methylumbelliferone against bile duct ligation-induced hepatic fibrosis rats

Naoya Sawada, Kenichiro Mikami, Go Igarashi, Tetsu Endo, Ken Sato, Ikuko Kakizaki, and Shinsaku Fukuda

The Hirosaki Medical Journal   66 ( 2-4 )   143 - 151   2016.3

Enzymatic synthesis of hyaluronan hybrid urinary trypsin inhibitor.

Ikuko Kakizaki, Ryoki Takahashi, Miho Yanagisawa, Futaba Yoshida, Keiichi Takagaki

Carbohydrate research   413   129 - 134   2015.9

Characterization of Proteoglycan and Hyaluronan in Water-based Delipidated Powder of Salmon Cartilage

Kakizaki I., Miura, A., Ito, S., Mineta, T., Hong, J.S., and Kato, Y.

Journal of Applied Glycoscience   62 ( 3 )   115 - 120   2015.9

Inhibitory effect of chondroitin sulfate oligosaccharides on bovine testicular hyaluronidase.

Ikuko Kakizaki, Hideyo Koizumi, Fengchao Chen, Masahiko Endo

Carbohydrate polymers   121   362 - 371   2015.5

Chondroitin sulfate cluster of epiphycan from salmon nasal cartilage defines binding specificity to collagens.

Yota Tatara, Ikuko Kakizaki, Shinichiro Suto, Haruna Ishioka, Mika Negishi, Masahiko Endo

Glycobiology   25 ( 5 )   557 - 569   2015.5

Biochemical and atomic force microscopic characterization of salmon nasal cartilage proteoglycan.

Ikuko Kakizaki, Takashi Mineta, Mana Sasaki, Yota Tatara, Eiji Makino, Yoji Kato

Carbohydrate polymers   103   538 - 549   2014.3

One set system for the synthesis and purification of glycosaminoglycan oligosaccharides reconstructed using a hyaluronidase-immobilized column.

Shinichiro Suto, Ikuko Kakizaki, Toshiya Nakamura, Masahiko Endo

Biopolymers   2014.3

Effect of a cholesterol-rich lipid environment on the enzymatic activity of reconstituted hyaluronan synthase.

Pawared Ontong, Yasuyo Hatada, Shun'ichiro Taniguchi, Ikuko Kakizaki, Naoki Itano

Biochemical and biophysical research communications   443 ( 2 )   666 - 671   2014.1

Synthesis of N-acetyl glucosamine analogs as inhibitors for hyaluronan biosynthesis.

Gilbert Wasongaa, Yota Tatarab, Ikuko Kakizaki, Xuefei Huanga

Journal of Carbohydrate Chemistry   32   392 - 409   2013.9

Epiphycan from salmon nasal cartilage is a novel type of large leucine-rich proteoglycan.

Yota Tatara, Ikuko Kakizaki, Yoshiyuki Kuroda, Shinichiro Suto, Haruna Ishioka, Masahiko Endo

Glycobiology   23 ( 8 )   993 - 1003   2013.8

Time-dependent gene expression and immunohistochemical analysis of the injured anterior cruciate ligament.

T Naraoka, Y Ishibashi, E Tsuda, Y Yamamoto, T Kusumi, I Kakizaki, S Toh

Bone & joint research   1 ( 10 )   238 - 244   2012.10

Hyaluronan-chondroitin hybrid oligosaccharides as new life science research tools.

Ikuko Kakizaki, Shinichiro Suto, Yota Tatara, Toshiya Nakamura, Masahiko Endo

Biochemical and biophysical research communications   423 ( 2 )   344 - 349   2012.6

Interaction of Listeria monocytogenes autolysin amidase with glycosaminoglycans promotes listerial adhesion to mouse hepatocytes.

Krisana Asano, Ikuko Kakizaki, Akio Nakane

Biochimie   94 ( 6 )   1291 - 1299   2012.6

Anti-inflammatory effect of proteoglycan and progesterone on human uterine cervical fibroblasts.

Asami Fukuyama, Kanji Tanaka, Ikuko Kakizaki, Kosuke Kasai, Mitsuru Chiba, Toshiya Nakamura, Hideki Mizunuma

Life sciences   90 ( 13-14 )   484 - 488   2012.4

Effects of divalent cations on bovine testicular hyaluronidase catalyzed transglycosylation of chondroitin sulfates.

Kakizaki, I., Nukatsuka, I., Takagaki, K., Majima, M., Iwafune, M., Suto, S., Endo, M.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   406 ( 2 )   239 - 244   2011.3

Analysis of functional sugar chains of proteoglycan in the urine from woman with osteoporosis.

Abe, K., Higuchi, T., Mizunuma, H., Kakizaki, I., Endo, M., and Suto, S.

Hirosaki Med. J.   61 ( 2-4 )   97 - 103   2011.3

Identification of proteoglycan from salmon nasal cartilage.

Kakizaki, I., Tatara, Y., Majima, M., Kato, Y., Endo, M.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   506 ( 1 )   58 - 65   2011.2

Method for hybrid synthesis of glycosaminoglycan chains Utilizing Chemo-enzymatic Procedures.

Yamaguchi, M., Kakizaki, I., and Endo, M.

J. Carbohyd. Chem.   29   315 - 331   2010.11

Mechanism for the hydrolysis of hyaluronan oligosaccharides by bovine testicular hyaluronidase.

Kakizaki, I., Ibori, N., Kojima, K., Yamaguchi, M., Endo M.

FEBS Journal   277 ( 7 )   1776 - 1786   2010.4

Novel proteoglycan glycotechnology: chemoenzymatic synthesis of chondroitin sulfate-containing molecules and its application.

Masanori Yamaguchi, Keiichi Takagaki, Kaoru Kojima, Naohiro Hayashi, Fengchao Chen, Ikuko Kakizaki, Atsushi Kon, Masahiko Endo

Glycoconjugate journal   27 ( 1 )   189 - 198   2010.1

Novel products in hyaluronan digested by bovine testicular hyaluronidase.

Chen, F., Kakizaki, I., Yamaguchi, M., Kojima, K., Takagaki, K., and Endo, M.

Glycoconj. J.   26 ( 5 )   559 - 566   2009.11

Stimulation of small proteoglycan synthesis by the hyaluronan synthesis inhibitor 4-methylumbelliferone in human skin fibroblasts.

Funahashi, M., Nakamura, T., Kakizaki, I., Mizunuma, H., and Endo, M.

Connect Tissue Res.   50 ( 3 )   194 - 202   2009.7

Structural Interactions in Chondroitin 4-Sulfate-mediated Adherence of Plasmodium falciparum-infected Erythrocytes in Human Placenta During Pregnancy-Associated Malaria.

Achur RN, Kakizaki I, Goel S, Kojima K, Madhunapantula SV, Goyal A, Ohta M, Kumar S, Takagaki K, Gowda DC.

Biochemistry   47 ( 47 )   12635 - 12643   2008.11

Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation.

Kakizaki, I., Itano, N., Kimata, K., Hanada, K., Kon, A., Yamaguchi, M., Takahashi, T., Takagaki, K.

Archives of biochemistry and biophysics   471 ( 1 )   85 - 93   2008.3

Inhibitory effect of 4-methylesculetin on hyaluronan synthesis slows the development of human pancreatic cancer in vitro and in nude mice.

Morohashi, H., Yoshihara, S., Nakai, M., Yamaguchi, M., Kakizaki, I., Kon, A., Sasaki, M., and Takagaki, K.

International journal of cancer   120 ( 12 )   2704 - 2709   2007.6

Diversity in the degree of sulfation and chain length of the glycosaminoglycan moiety of urinary trypsin inhibitor isomers.

Kakizaki, I., Takahashi, R., Ibori, N., Kojima, K., Takahashi, T., Yamaguchi, M., Kon, A., and Takagaki, K.

Biochimica et biophysica acta   1770 ( 2 )   171 - 177   2007.2

Efficient and widely applicable method of constructing neo-proteoglycan utilizing copper(I) catalyzed 1,3-dipolar cycloaddition.

Yamaguchi, M., Kojima, K., Hayashi, N., Kakizaki, I., Kon A., and Takagaki, K.

Tetrahedron Letter   47 ( 42 )   7455 - 7458   2006.8

Study of hyaluronan synthase inhibitor, 4-methylumbelliferone derivatives on human pancreatic cancer cell (KP1-NL).

Morohashi, H., Kon, A., Nakai, M., Yamaguchi, M., Kakizaki, I., Yoshihara S., Sasaki, M., and Takagaki, K.

Biochemical and biophysical research communications   345 ( 4 )   1454 - 1419   2006.7

The effects of glycosaminoglycans on thrombopoietin-induced megakaryocytopoiesis.

Kashiwakura, I., Teramachi, T., Kakizaki, I., Takagi, Y., Takahashi, T. A., and Takagaki, K.

Haematologica   91 ( 4 )   445 - 451   2006.4

The glycophorin C N-linked glycan is a critical component of the ligand for the Plasmodium falciparum erythrocyte receptor BAEBL.

Mayer, D.C., Jiang, L., Achur, R.N., Kakizaki, I., Gowda, D.C., and Miller, L.H.

Proceedings of the National Academy of Sciences of the United States of America   103 ( 7 )   2358 - 2362   2006.2

4-methylumbelliferone, a hyaluronan synthase suppressor, enhances the anticancer activity of gemcitabine in human pancreatic cancer cells.

Nakazawa, H., Yoshihara, S., Kudo, D., Morohashi, H., Kakizaki, I., Kon, A., Takagaki, K., and Sasaki, M.

Cancer chemotherapy and pharmacology Links   57 ( 2 )   165 - 170   2006.1

A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells.

Yoshihara S., Kon A., Kudo D., Nakazawa H., Kakizaki I., Sasaki M., Endo M., and Takagaki K.

FEBS letters   579 ( 12 )   2722 - 2726   2005.5

Effect of a hyaluronan synthase suppressor, 4-methylumbelliferone, on B16F-10 melanoma cell adhesion and locomotion.

Kudo, D., Kon, A., Yoshihara, S., Kakizaki, I., Sasaki, M., Endo, M., and Takagaki, K.

Biochemical and biophysical research communications   321 ( 4 )   783 - 787   2004.9

A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbeliifieron.

Kakizaki, I., Kojima, K., Takagaki, K., Endo, M., Kannagi, R., Ito, M., Maruo, Y., Sato, H., Yasuda, T., Mita, S., Kimata, K., and Itano, N.

The Journal of biological chemistry   279 ( 32 )   33281 - 33289   2004.8

Structural characterization of the bovine tracheal chondroitin sulfate chains and binding of Plasmodium falciparum-infected erythrocytes.

Muthusamy, A., Achur, R. N., Valiyaveettil, M., Madhunapantula, S. V., Kakizaki, I., Bhavanandan, V. P., and Gowda, C. D.

Glycobiology   14 ( 7 )   635 - 645   2004.7

Inhibition of 3T3-L1 adipocyte differentiation by 6-ethoxyzolamide: repressed peroxisome proliferator-activated receptor gamma mRNA and enhanced CCAAT/enhancer binding protein beta mRNA levels.

Takahata, T., Kumano, T., Ookawa, K., Hayakari, M., Kakizaki, I., and Tsuchida, S.

Biochemical pharmacology   67 ( 9 )   1667 - 1675   2004.5

A glycomic approach to proteoglycan with a two-dimensional polysaccharide chain map.

Iwafune, M., Kakizaki, I., Nakazawa, H., Nukatsuka, I., Endo, M., and Takagaki, K.

Analytical biochemistry   325 ( 1 )   35 - 40   2004.2

A novel Sp1-family-related cis-acting element for transcription of type VII collagen gene (COL7A1).

Hideyuki Sasaki, Atsushi Kon, Hitoshi Takeda, Daisuke Sawamura, Ikuko Kakizaki, Keiichi Takagaki, Isao Hashimoto, Katsumi Hanada

Journal of dermatological science   32 ( 3 )   239 - 242   2003.9

Reconstruction of glycosaminoglycan chains in decorin.

Mito Iwafune, Ikuko Kakizaki, Masahiro Yukawa, Daisuke Kudo, Sakae Ota, Masahiko Endo, Keiichi Takagaki

Biochemical and biophysical research communications   297 ( 5 )   1167 - 1170   2002.10

Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone.

Ikuko Kakizaki, Keiichi Takagaki, Yasufumi Endo, Daisuke Kudo, Hitoshi Ikeya, Teruzo Miyoshi, Bruce A Baggenstoss, Valarie L Tlapak-Simmons, Kshama Kumari, Akio Nakane, Paul H Weigel, Masahiko Endo

European journal of biochemistry / FEBS   269 ( 20 )   5066 - 5075   2002.10

Activation of mouse Pi-class glutathione S-transferase gene by Nrf2(NF-E2-related factor 2) and androgen.

Hiromi Ikeda, Mohamed S Serria, Ikuko Kakizaki, Ichiro Hatayama, Kimihiko Satoh, Shigeki Tsuchida, Masami Muramatsu, Shinzo Nishi, Masaharu Sakai

The Biochemical journal   364 ( Pt 2 )   563 - 570   2002.6

Cleavage of the xylosyl serine linkage between a core peptide and a glycosaminoglycan chain by cellulases.

Keiichi Takagaki, Mito Iwafune, Ikuko Kakizaki, Keinosuke Ishido, Yoji Kato, Masahiko Endo

The Journal of biological chemistry   277 ( 21 )   18397 - 18403   2002.5

Carriers for enzymatic attachment of glycosaminoglycan chains to peptide.

Keiichi Takagaki, Keinosuke Ishido, Ikuko Kakizaki, Mito Iwafune, Masahiko Endo

Biochemical and biophysical research communications   293 ( 1 )   220 - 224   2002.4

Domain structure of chondroitin sulfate E octasaccharides binding to type V collagen.

Keiichi Takagaki, Hidekazu Munakata, Ikuko Kakizaki, Mito Iwafune, Taito Itabashi, Masahiko Endo

The Journal of biological chemistry   277 ( 11 )   8882 - 8889   2002.3

Studies on sugar chain elongation in cultured human colon adenocarcinoma cells using 4-methylumbelliferyl glycoside derivatives and p-nitrophenyl glycoside derivatives as artificial primers.

Kukidome, J., Kakizaki, I., Takagaki, K., and Endo, M.

Hirosaki Med. J.   194 ( 1 )   59 - 65   2001.10

The mechanism of cell death in human cultured colon adenocarcinoma cell line COLO 201 induced by beta-D-N-acetylglucosaminyl-p-nitrophenol.

J Kukidome, I Kakizaki, K Takagaki, A Matsuki, A Munakata, M Endo

The Tohoku journal of experimental medicine   194 ( 1 )   23 - 34   2001.5

Induction of apoptosis and cell cycle arrest in mouse colon 26 cells by benastatin A.

I Kakizaki, K Ookawa, T Ishikawa, M Hayakari, T Aoyagi, S Tsuchida

Japanese journal of cancer research : Gann   91 ( 11 )   1161 - 1168   2000.11

Enzymatic reconstruction of dermatan sulfate.

K Takagaki, H Munakata, I Kakizaki, M Majima, M Endo

Biochemical and biophysical research communications   270 ( 2 )   588 - 593   2000.4

Chimeric glycosaminoglycan oligosaccharides synthesized by enzymatic reconstruction and their use in substrate specificity determination of Streptococcus hyaluronidase.

K Takagaki, H Munakata, M Majima, I Kakizaki, M Endo

Journal of biochemistry   127 ( 4 )   695 - 702   2000.4

Identification of glutathione S-transferase p-1 as the class pi form dominantly expressed in mouse hepatic adenomas.

K Ookawa, H Nakano, I Kakizaki, I Hatayama, H Kajihara-Kano, J Kimura, M Hayakari, T Takahata, K Satoh, S Tsuchida

Japanese journal of cancer research : Gann   89 ( 6 )   641 - 648   1998.6

Epitope mapping of a monoclonal antibody to human glutathione transferase P1-1 the binding of which is inhibited by glutathione.

T Takahata, S Tsuchida, M Oomura, T Matsumoto, J Azumi, I Hatayama, M Hayakari, J Kimura, I Kakizaki, H Kano, K Satoh, K Sato

The Biochemical journal   321 ( Pt 2)   531 - 536   1997.1

Lentinan enhances sensitivity of mouse colon 26 tumor to cis-diamminedichloroplatinum (II) and decreases glutathione transferase expression.

T Murata, I Hatayama, I Kakizaki, K Satoh, K Sato, S Tsuchida

Japanese journal of cancer research : Gann   87 ( 11 )   1171 - 1178   1996.11

cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein.

H Nishimura, I Kakizaki, T Muta, N Sasaki, P X Pu, T Yamashita, S Nagasawa

FEBS letters   357 ( 2 )   207 - 211   1995.1

Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene.

Y Negishi, Y Nishita, Y Saëgusa, I Kakizaki, I Galli, F Kihara, K Tamai, N Miyajima, S M Iguchi-Ariga, H Ariga

Oncogene   9 ( 4 )   1133 - 1143   1994.4

Cell cycle-dependent activation of C-myc enhancer.

I Kakizaki, Y Imamura, I Galli, F Kihara, H Ariga, S Iguchiariga

International journal of oncology   2 ( 4 )   657 - 661   1993.4

Endoglycosidases (Glycosaminoglycans)

Kakizaki, I., and Takagaki, K.（ Role： Joint author ,  p173-p176）

Springer  2008.2 

Degradation of glycosaminoglycans, in Comprehensive Glycoscience - from Chemistry to Systems Biology

Takagaki, K., and Kakizaki, I.（ Role： Joint author ,  p171-p192）

Elsevier Science B. V.  2007.8 

A possible cardiolipin-dependent inhibition mechanism of hyaluronan synthesis by 4-methylumbelliferone in streptococcus equi FM100, in Hyaluronan 2003 Conference Proceedings” Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications”

Kakizaki, I., Baggenstoss, B. A., Tlapak-Simmons, V. L., Nakane, A., Weigel, P. H., Endo, M., and Takagaki, K.（ Role： Joint author ,  p159–p163）

Matrix Biology Institute  2005.1 

Custom synthesis of hyaluronan/chondroitin sulfate hybrid oligosaccharides: for future medical applications

Kakizaki, I., Suto, S., Tatara, Y., and Endo, M.

Hirosaki Med. J.   64 ( 64 (Suppl.) )   S53 - S57   2013.5

Synthesis of neoproteoglycans using the transglycosylation reaction as a reverse reaction of endo-glycosidases.

Endo, M., and Kakizaki, I.

Proc. Jpn. Acad., Ser. B.   88 ( 7 )   327 - 344   2012.7

Proteoglycan glycotechnology for possible medical application

61 ( 3 )   216 - 220   2010.3

Hyaluronan Degradation in Tumor Growth and Metastasis（翻訳）

Stern, R

Trends in Glycoscience and Glycotechnology   16 ( 89 )   171 - 185   2004.5

弘大60周年記念事業プレ企画「科学者発見プロジェクト」における共同研究

2010.09

弘大60周年記念事業プレ企画「科学者発見プロジェクト」における共同研究

2008.11 - 2009.01

（一財）双仁会厚生看護専門学校　非常勤講師（生化学）

2006.09