Papers - NAKAJIMA Akira
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Allopurinol induces innate immune responses through mitogen-activated protein kinase signaling pathways in HL-60 cells.
Nakajima A, Oda S, Yokoi T
J Appl Toxicol. 36 1120 - 1128 2016
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Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer’s disease (3XTg-AD).
Nakajima A, Aoyama Y, Shin EJ, Nam Y, Kim HC, Nagai T, Yokosuka A, Mimaki Y, Yokoi T, Ohizumi Y, Yamada K
Behav Brain Res. 269 69 - 77 2015
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Induction of interferon-induced transmembrane protein 3 gene expression by lipopolysaccharide in astrocytes.
Nakajima A, Ibi D, Nagai T, Yamada S, Nabeshima T, Yamada K
Eur J Pharmacol. 2014
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Expression of the G72/G30 gene in transgenic mice induces behavioral changes.
Cheng L, Hattori E, Nakajima A, Woehrle NS, Opal MD, Zhang C, Grennan K, Dulawa SC, Tang YP, Gershon ES, Liu C
Mol Psychiatry. 19 175 - 183 2014
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Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes.
Yamada S, Nagai T, Nakai T, Ibi D, Nakajima A, Yamada K
Brain Behav Immun. 38 272 - 282 2014
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Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse.
Nakajima A, Aoyama Y, Nguyen TY, Shin EJ, Kim HC, Yamada S, Nakai T, Nagai T, Yokosuka A, Mimaki Y, Ohizumi Y, Yamada K
Behav Brain Res. 250 351 - 360 2013
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SLC10A4 is a protease-activated transporter that transports bile acids.
Abe T, Kanemitu Y, Nakasone M, Kawahata I, Yamakuni T, Nakajima A, Suzuki N, Nishikawa M, Hishinuma T, Tomioka Y
J Biochem. 154 93 - 101 2013
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Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.
Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, Kano SI, Sato Y, Hayakawa M, Lange UC, Adams DJ, Surani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T, Yamada K
Glia. 61 679 - 693 2013
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Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action.
Kawahata I, Yoshida M, Sun W, Nakajima A, Lai Y, Osaka N, Matsuzaki K, Yokosuka A, Mimaki Y, Naganuma A, Tomioka Y, Yamakuni T
J Neural Transm. 120 1397 - 1409 2013
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Repeated treatment with nicotine induces phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization.
Nakajima A, Kinugasa Y, Torii J, Hishinuma T, Tomioka Y, Yamada K, Yamakuni T
Neurosci Lett. 524 133 - 138 2012
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Post-training dephosphorylation of eEF-2 promotes protein synthesis for memory consolidation.
Im HI, Nakajima A, Gong B, Xiong X, Mamiya T, Gershon ES, Zhuo M, Tang YP
PLoS ONE. 13 e7424 2009
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Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.
Yamamoto Y, Shioda N, Han F, Moriguchi S, Nakajima A, Yokosuka A, Mimaki Y, Sashida Y, Yamakuni T, Ohizumi Y, Fukunaga K
Brain Res. 1295 218 - 229 2009
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4´-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor-antagonism via stimulation of ERK cascade.
Rahim Md Al, Nakajima A, Saigusa D, Tetsu N, Maruyama Y, Shibuya M, Yamakoshi H, Tomioka Y, Iwabuchi Y, Ohizumi Y, Yamakuni T
Biochemistry. 18 7713 - 7721 2009
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Neurobehavioral effects of tetrabromobisphenol A, a brominated flame retardant, in mice.
Nakajima A, Saigusa D, Tetsu N, Yamakuni T, Tomioka Y, Hishinuma T
Toxicol Lett. 189 78 - 83 2009
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A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Aβ-inhibition of the cascade in cultured rat CNS neurons.
Rahim Md Al, Nakajima A, Misawa N, Shindo K, Adachi K, Shizuri Y, Ohizumi Y, Yamakuni T
Eur J Pharmacol. 600 10 - 17 2008
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Adult neurogenesis is functionally associated with AD-like neurodegeneration.
Chen Q, Nakajima A, Choi SH, Xiong X, Sisodia SS, Tang YP
Neurobiol Dis. 29 316 - 326 2008
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Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse.
Chen Q, Nakajima A, Choi SH, Xiong X, Tang YP
J Neurosci Res. 86 1615 - 1625 2008
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Expression of NR2B in Cerebellar Granule Cells Specifically Facilitates Effect of Motor Training on Motor Learning.
Jiao J, Nakajima A, Janssen WG, Bindokas VP, Xiong X, Morrison JH, Brorson JR, Tang YP
PLoS ONE. 3 ( e1684 ) 1 - 11 2008
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Nobiletin, a citrus flavonoid, improves memory impairment and Aβ pathology in a transgenic mouse model of Alzheimer’s disease.
Onozuka H, Nakajima A, Matsuzaki K, Shin RW, Ogino K, Saigusa D, Tetsu N, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y
J Pharmacol Exp Ther. 326 739 - 744 2008
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Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.
Nakajima A, Yamakuni T, Haraguchi M, Omae N, Song SY, Kato C, Tadano T, Yokosuka A, Mimaki Y, Sashida Y, Ohizumi Y
J Pharmacol Sci. 105 122 - 126 2007