Papers - KASAI Syuya
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Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study.
Shimizu S, Kasai S, Suzuki C, Kon T, Suganuma H, Suzuki S, Murashita K, Nakaji S, Ihara K, Tomiyama M, Itoh K
Frontiers in nutrition 13 1740494 2026
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Mitochondrial Reactive Oxygen Species, Insulin Resistance, and Nrf2-Mediated Oxidative Stress Response—Toward an Actionable Strategy for Anti-Aging
Shuya Kasai, Daichi Kokubu, Hiroki Mizukami, Ken Itoh
Biomolecules 13 ( 10 ) 2023.10
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Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage
Jun Liu, Shuya Kasai, Yota Tatara, Hiromi Yamazaki, Junsei Mimura, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Kunikazu Tanji, Koichi Wakabayashi, Hayato Maeda, Hiroki Mizukami, Yasuhiro Shinkai, Yoshito Kumagai, Hirofumi Tomita and Ken Itoh
International Journal of Molecular Sciences 2022.3
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Multi-marker discovery for mild cognitive impairment in metabolomics using machine learning with a global surrogate model via partial least squares
Yota Tatara, Hiroyuki Yamamoto, Kozue Terai, Rira Matsuta, Shuya Kasai, Yoshinori Tamada, Tatsuya Mikami, Koichi Murashita, Ken Itoh
METABOLOMICS 21 ( 6 ) 164 2025.11
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Spatial colocalization and molecular crosstalk of myofibroblastic CAFs and tumor cells shape lymph node metastasis in oral squamous cell carcinoma.
Furudate K, Kasai S, Yoshizawa T, Sasaki Y, Fujikura K, Goto S, Ito R, Takagi K, Tanaka T, Kijima H, Kubota K, Itoh K, Kobayashi W, Takahashi K
PLoS genetics 21 ( 9 ) e1011791 2025.9
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Intranasal administration of ergothioneine improves memory in a mouse model of multiple system atrophy.
Kazuto Kimura, Makoto Timon Tanaka, Yasuo Miki, Tomonori Furukawa, Shuya Kasai, Taku Ozaki, Fumiaki Mori, Eri Shibuya, Koichi Wakabayashi
Biochemical and biophysical research communications 756 151550 - 151550 2025.2
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Selenoprotein-Mediated Redox Regulation Shapes the Cell Fate of HSCs and Mature Lineages
Yumi Aoyama, Hiromi Yamazaki, Koutarou Nishimua, Masaki Nomura, Tsukasa Shigehiro, Takafumi Suzuki, Weijia Zang, Yota Tatara, Hiromi Ito, Yasutaka Hayashi, Yui Koike, Miki Fukumoto, Atsushi Tanaka, Yifan Zhang, Wataru Saika, Chihiro Hasegawa, Shuya Kasai, Yingyi Kong, Yohei Minakuchi, Ken Itoh, Masayuki Yamamoto, Shinya Toyokuni, Atsushi Toyoda, Tomokatsu Ikawa, Akifumi Takaori-Kondo, Daichi Inoue
Blood Journal 145 ( 11 ) 1149 - 1163 2025.1
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Association between NF-E2-related factor 2 polymorphism and age-related hearing loss in the general Japanese population from the Iwaki health promotion project.
Takashi Kasai, Akira Sasaki, Shuya Kasai, Shiori Miura, Shinichi Goto, Ryoko Yotsuyanagi, Tatsuya Mikami, Yoshinori Tamada, Ken Itoh, Atsushi Matsubara
Acta oto-laryngologica 145 ( 1 ) 1 - 7 2024.12
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Emerging Role of GCN1 in Disease and Homeostasis.
Tatara Y, Kasai S, Kokubu D, Tsujita T, Mimura J, Itoh K
International journal of molecular sciences 25 ( 5 ) 2024.3
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Role of Nrf2-Mediated Oxidative Stress Response Pathway in the Regulation of Mibyou
ITOH Ken, KASAI Shuya, TATARA Yota
KAGAKU TO SEIBUTSU 62 ( 3 ) 145 - 153 2024.3
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Altered structural hippocampal intra-networks in a general elderly Japanese population with mild cognitive impairment.
Kasai S, Watanabe K, Umemura Y, Ishimoto Y, Sasaki M, Nagaya H, Tatsuo S, Mikami T, Tamada Y, Ide S, Tomiyama M, Matsuzaka M, Kakeda S
Scientific reports 13 ( 1 ) 13330 2023.8
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Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation.
Atsushi Inose-Maruyama, Shuya Kasai, Ken Itoh
Methods in molecular biology (Clifton, N.J.) 2651 157 - 166 2023
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Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment
Yota Tatara, Hiromi Yamazaki, Fumiki Katsuoka, Mitsuru Chiba, Daisuke Saigusa, Shuya Kasai, Tomohiro Nakamura, Jin Inoue, Yuichi Aoki, Miho Shoji, Ikuko Motoike, Yoshinori Tamada, Katsuhito Hashizume, Mikio Shoji, Kengo Kinoshita, Koichi Murashita, Shigeyuki Nakaji, Masayuki Yamamoto, Ken Itoh
Current Research in Translational Medicine 71 ( 1 ) 103367 - 103367 2022.10
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Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice
Sunao Shimizu, Shuya Kasai, Hiromi Yamazaki, Yota TATARA, Junsei Mimura, Máté János Engler, Kunikazu Tanji, Yoshikazu Nikaido, Takuro Inoue, Hiroyuki Suganuma, Koichi Wakabayashi, Ken Itoh
International Journal of Molecular Sciences 23 ( 15 ) 2022.7
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Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage
Jun Liu, Shuya Kasai, Yota Tatara, Hiromi Yamazaki, Junsei Mimura, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Kunikazu Tanji, Koichi Wakabayashi, Hayato Maeda, Hiroki Mizukami, Yasuhiro Shinkai, Yoshito Kumagai, Hirofumi Tomita, Ken Itoh
International Journal of Molecular Sciences 23 ( 6 ) 3201 - 3201 2022.3
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Association of mitochondrial DNA haplogroup and hearing impairment with aging in Japanese general population of the Iwaki Health Promotion Project
Shiori Miura, Akira Sasaki, Shuya Kasai, Takayuki Sugawara, Yasunori Maeda, Shinichi Goto, Takashi Kasai, Nami Shimizume, Songee Jung, Takuro Iwane, Ken Itoh, Atsushi Matsubara
Journal of Human Genetics 67 ( 6 ) 369 - 375 2022.1
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Direct protein–protein interaction between Npas4 and IPAS mutually inhibits their critical roles in neuronal cell survival and death
Shuya Kasai, Xianyu Li, Satoru Torii, Ken-ichi Yasumoto and Kazuhiro Sogawa
Cell Death Discovery 2021.10
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多層オミックスと機械学習による軽度認知障害の予測モデルの構築
多田羅 洋太, 中村 智洋, 千葉 満, 三枝 大輔, 山嵜 博未, 勝岡 史城, 葛西 秋宅, 川瀬 倫子, 本間 リナ, 松田 りら, 藤本 哲太, 荘司 美穂, 元池 育子, 玉田 嘉紀, 橋爪 克仁, 東海林 幹夫, 木下 賢吾, 伊東 健
Dementia Japan 35 ( 4 ) 660 - 660 2021.10
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Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis
Mayu Sugawara, Takumi Abe, Shuya Kasai, Ken Itoh, Taku Ozaki
Biochemistry and Biophysics Reports 27 101101 - 101101 2021.8
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Attenuation of inhibitory PAS domain protein-induced cell death by synthetic peptides derived from Mcl-1 transmenbrane domain
Shuya Kasai, Ken-ichi Yasumoto, Kazuhiro Sogawa
CELL DEATH DISCOVERY 7 ( 1 ) 92 2021.5