Papers - KASAI Syuya
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Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage
Jun Liu, Shuya Kasai, Yota Tatara, Hiromi Yamazaki, Junsei Mimura, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Kunikazu Tanji, Koichi Wakabayashi, Hayato Maeda, Hiroki Mizukami, Yasuhiro Shinkai, Yoshito Kumagai, Hirofumi Tomita and Ken Itoh
International Journal of Molecular Sciences 2022.3
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Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology
Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura, Ken Itoh
BIOMOLECULES 10 ( 2 ) 320 - 320 2020.2
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Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control.
Shuya Kasai, Hiromi Yamazaki, Kunikazu Tanji, Máté János Engler, Tomoh Matsumiya, Ken Itoh
Journal of clinical biochemistry and nutrition 64 ( 1 ) 1 - 12 2019.1
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Emerging Role of GCN1 in Disease and Homeostasis.
Tatara Y, Kasai S, Kokubu D, Tsujita T, Mimura J, Itoh K
International journal of molecular sciences 25 ( 5 ) 2024.3
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Mitochondrial Reactive Oxygen Species, Insulin Resistance, and Nrf2-Mediated Oxidative Stress Response-Toward an Actionable Strategy for Anti-Aging.
Kasai S, Kokubu D, Mizukami H, Itoh K
Biomolecules 13 ( 10 ) 2023.10
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Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation.
Atsushi Inose-Maruyama, Shuya Kasai, Ken Itoh
Methods in molecular biology (Clifton, N.J.) 2651 157 - 166 2023
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Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment
Yota Tatara, Hiromi Yamazaki, Fumiki Katsuoka, Mitsuru Chiba, Daisuke Saigusa, Shuya Kasai, Tomohiro Nakamura, Jin Inoue, Yuichi Aoki, Miho Shoji, Ikuko N Motoike, Yoshinori Tamada, Katsuhito Hashizume, Mikio Shoji, Kengo Kinoshita, Koichi Murashita, Shigeyuki Nakaji, Masayuki Yamamoto, Ken Itoh
71 ( 1 ) 103367 2022.10
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Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice
Sunao Shimizu, Shuya Kasai, Hiromi Yamazaki, Yota TATARA, Junsei Mimura, Máté János Engler, Kunikazu Tanji, Yoshikazu Nikaido, Takuro Inoue, Hiroyuki Suganuma, Koichi Wakabayashi, Ken Itoh
International Journal of Molecular Sciences 23 ( 15 ) 2022.7
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Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage
Jun Liu, Shuya Kasai, Yota Tatara, Hiromi Yamazaki, Junsei Mimura, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Kunikazu Tanji, Koichi Wakabayashi, Hayato Maeda, Hiroki Mizukami, Yasuhiro Shinkai, Yoshito Kumagai, Hirofumi Tomita, Ken Itoh
International Journal of Molecular Sciences 23 ( 6 ) 3201 - 3201 2022.3
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Association of mitochondrial DNA haplogroup and hearing impairment with aging in Japanese general population of the Iwaki Health Promotion Project
Shiori Miura, Akira Sasaki, Shuya Kasai, Takayuki Sugawara, Yasunori Maeda, Shinichi Goto, Takashi Kasai, Nami Shimizume, Songee Jung, Takuro Iwane, Ken Itoh, Atsushi Matsubara
Journal of Human Genetics 67 ( 6 ) 369 - 375 2022.1
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Direct protein–protein interaction between Npas4 and IPAS mutually inhibits their critical roles in neuronal cell survival and death
Shuya Kasai, Xianyu Li, Satoru Torii, Ken-ichi Yasumoto and Kazuhiro Sogawa
Cell Death Discovery 2021.10
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多層オミックスと機械学習による軽度認知障害の予測モデルの構築
多田羅 洋太, 中村 智洋, 千葉 満, 三枝 大輔, 山嵜 博未, 勝岡 史城, 葛西 秋宅, 川瀬 倫子, 本間 リナ, 松田 りら, 藤本 哲太, 荘司 美穂, 元池 育子, 玉田 嘉紀, 橋爪 克仁, 東海林 幹夫, 木下 賢吾, 伊東 健
Dementia Japan 35 ( 4 ) 660 - 660 2021.10
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Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis
Mayu Sugawara, Takumi Abe, Shuya Kasai, Ken Itoh, Taku Ozaki
Biochemistry and Biophysics Reports 27 101101 - 101101 2021.8
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Attenuation of inhibitory PAS domain protein-induced cell death by synthetic peptides derived from Mcl-1 transmenbrane domain
Shuya Kasai, Ken-ichi Yasumoto, Kazuhiro Sogawa
CELL DEATH DISCOVERY 7 ( 1 ) 92 2021.5
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The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress
Marie-France Dorion, Mukandila Mulumba, Shuya Kasai, Ken Itoh, William D. Lubell, Huy Ong
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2021 6691402 2021.3
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Nrf2とATF4の相互作用を基盤にした未病気における疾患予防法の開発
葛西 秋宅
BIO Clinica 36 80 - 84 2021
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特集 慢性腎臓病・透析患者の酸化ストレス-最新知見と治療展開 2.慢性腎臓病における酸化ストレス進展機序(1) 慢性腎臓病におけるNrf2-Keap1 経路の役割-CKD 治療薬としての期待
伊東 健, Liu Jun, 葛西 秋宅
臨床透析 36 ( 12 ) 1521 - 1527 2020.11
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Prevalence of the mitochondrial 1555 A > G and 1494 C > T mutations in a community-dwelling population in Japan (vol 7, 27, 2020)
Yasunori Maeda, Akira Sasaki, Shuya Kasai, Shinichi Goto, Shin-ya Nishio, Kaori Sawada, Itoyo Tokuda, Ken Itoh, Shin-ichi Usami, Atsushi Matsubara
HUMAN GENOME VARIATION 7 ( 1 ) 27 - 27 2020.10
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Prevalence of the mitochondrial 1555 A>G and 1494 C>T mutations in a community-dwelling population in Japan.
Maeda Y, Sasaki A, Kasai S, Goto S, Nishio SY, Sawada K, Tokuda I, Itoh K, Usami SI, Matsubara A.
Hum Genome Var. 2020.9
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Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging.
Shimizu S, Mimura J, Hasegawa T, Shimizu E, Imoto S, Tsushima M, Kasai S, Yamazaki H, Ushida Y, Suganuma H, Tomita H, Yamamoto M, Nakaji S, Itoh K.
PLoS One. 2020.8
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多層オミックス解析による認知症の早期発見のためのバイオマーカー探索
多田羅 洋太, 中村 智洋, 山嵜 博未, 勝岡 史城, 千葉 満, 三枝 大輔, 葛西 秋宅, 伊東 健
JSBMS Letters 45 ( Suppl. ) 32 - 32 2020.8
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Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice
Hiromi Yamazaki, David Ron, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Kunikazu Tanji, Koichi Wakabayashi, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Douglas R. Cavener, Masayuki Yamamoto, Ken Itoh
PLOS Genetics 16 ( 4 ) e1008693 2020.4
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Mitochondrial E3 Ubiquitin Ligase Parkin: Relationships with Other Causal Proteins in Familial Parkinson’s Disease and Its Substrate-Involved Mouse Experimental Models
Satoru Torii, Shuya Kasai, Tatsushi Yoshida, Ken-ichi Yasumoto, Shigeomi Shimizu
International Journal of Molecular Sciences 21 ( 4 ) 1202 - 1202 2020.2
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ストレス応答性転写因子Nrf2とATF4の相互作用を基盤にした疾患予防・アンチエイジング法の開発
葛西 秋宅
BIO Clinica 35 60 - 64 2020
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Deficiency of P62/SQSTM1 Exacerbates Doxorubicin-Induced Cardiac Dysfunction
Michiko Tsushima, Junsei Mimura, Jun Liu, Hiromi Yamazaki, Shuya Kasai, Hirofumi Tomita, Ken Itoh
CIRCULATION 140 2019.11
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Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes.
Junsei Mimura, Atsushi Inose-Maruyama, Shusuke Taniuchi, Kunio Kosaka, Hidemi Yoshida, Hiromi Yamazaki, Shuya Kasai, Nobuhiko Harada, Randal J Kaufman, Seiichi Oyadomari, Ken Itoh
International journal of molecular sciences 20 ( 7 ) 1706 2019.4
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Deficiency of protein-L-isoaspartate (D-aspartate) O-methyl-transferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma.
Masahiro Yamashita, Masahito Ogasawara, Yasushi Kawasaki, Miyuki Niisato, Heisuke Saito, Shuya Kasai, Chihaya Maesawa, Makoto Maemondo, Kohei Yamauchi
Oncotarget 9 ( 17 ) 13287 - 13300 2018.3
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Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease.
Shuya Kasai, Junsei Mimura, Taku Ozaki, Ken Itoh
Frontiers in veterinary science 5 242 - 242 2018
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Increase in proapoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2.
Shuya Kasai, Mary J E Richardson, Satoru Torii, Ken-Ichi Yasumoto, Hiroki Shima, Kazuhiko Igarashi, Ken Itoh, Kazuhiro Sogawa, Kazutaka Murayama
The FEBS journal 284 ( 23 ) 4115 - 4127 2017.12
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Bcl-2/Bcl-xL inhibitor ABT-737 sensitizes pancreatic ductal adenocarcinoma to paclitaxel-induced cell death.
Shuya Kasai, Takuya Sasaki, Ayano Watanabe, Masao Nishiya, Shinji Yasuhira, Masahiko Shibazaki, Chihaya Maesawa
Oncology letters 14 ( 1 ) 903 - 908 2017.7
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Conformational changes in inhibitory PAS domain protein associated with binding of HIF-1α and Bcl-xL in living cells.
Shuya Kasai, Shinji Kajimoto, Yuma Ito, Tomo Saito, Ken-Ichi Yasumoto, Makio Tokunaga, Kumiko Sakata-Sogawa, Hiroshi Fukumura, Kazuhiro Sogawa
Journal of biochemistry 161 ( 3 ) 291 - 296 2017.3
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NAD(P)H: Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG
Shuya Kasai, Nobuyuki Arakawa, Ayaka Okubo, Wataru Shigeeda, Shinji Yasuhira, Tomoyuki Masuda, Toshihide Akasaka, Masahiko Shibazaki, Chihaya Maesawa
PLOS ONE 11 ( 4 ) e0153181 2016.4
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Temporal expression in rats of receptor tyrosine kinase Tie2 during early wound healing after tooth extraction
Hirotaka Sato, Shuya Kasai, Chihaya Maesawa
JOURNAL OF ORAL SCIENCE 57 ( 4 ) 313 - 318 2015.12
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Inhibitory PAS domain protein is a substrate of PINK1 and Parkin and mediates cell death in a Parkinson's disease model.
S Kasai, S Torii, A Kakita, K Sogawa
Cell death & disease 6 e1886 - e1886 2015.9
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Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification.
Yoshinori Tatemichi, Masahiko Shibazaki, Shinji Yasuhira, Shuya Kasai, Hiroshi Tada, Hiroki Oikawa, Yuji Suzuki, Yasuhiro Takikawa, Tomoyuki Masuda, Chihaya Maesawa
Cancer science 106 ( 7 ) 848 - 856 2015.7
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Temporal expression in rats of receptor tyrosine kinase Tie2 during early wound healing after tooth extraction.
Hirotaka Sato, Shuya Kasai, Chihaya Maesawa
Journal of oral science 57 ( 4 ) 313 - 318 2015
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Involvement of inhibitory PAS domain protein in neuronal cell death in Parkinson's disease.
Torii S, Kasai S, Suzuki A, Todoroki Y, Yokozawa K, Yasumoto KI, Seike N, Kiyonari H, Mukumoto Y, Kakita A, Sogawa K
Cell death discovery 1 15015 2015
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Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.
Shinpei Miura, Chihaya Maesawa, Masahiko Shibazaki, Shinji Yasuhira, Syuya Kasai, Kanako Tsunoda, Fumihiko Maeda, Kazuhiro Takahashi, Toshihide Akasaka, Tomoyuki Masuda
The American Journal of dermatopathology 36 ( 3 ) 211 - 216 2014.3
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A somatic mutation of the KEAP1 gene in malignant melanoma is involved in aberrant NRF2 activation and an increase in intrinsic drug resistance.
Shinpei Miura, Masahiko Shibazaki, Shuya Kasai, Shinji Yasuhira, Ayano Watanabe, Tsuyoshi Inoue, Yuich Kageshita, Kanako Tsunoda, Kazuhiro Takahashi, Toshihide Akasaka, Tomoyuki Masuda, Chihaya Maesawa
The Journal of investigative dermatology 134 ( 2 ) 553 - 556 2014.2
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Dephosphorylation of Sp1 at Ser-59 by protein phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole.
Shuji Shimoyama, Shuya Kasai, Brigitte Kahn-Perlès, Hideaki Kikuchi
Biochimica et biophysica acta 1839 ( 2 ) 107 - 115 2014.2
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BCL2 and BCLxL are key determinants of resistance to antitubulin chemotherapeutics in melanoma cells
Ayano Watanabe, Shinji Yasuhira, Tsuyoshi Inoue, Shuya Kasai, Masahiko Shibazaki, Kazuhiro Takahashi, Toshihide Akasaka, Tomoyuki Masuda, Chihaya Maesawa
EXPERIMENTAL DERMATOLOGY 22 ( 8 ) 518 - 523 2013.8
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Beta-catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells.
Kasai S, Ishigaki T, Takumi R, Kamimura T, Kikuchi H
Biochimica et biophysica acta 1830 ( 3 ) 2509 - 2516 2013.3
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Transcriptional and post-transcriptional regulation of beta III-tubulin protein expression in relation with cell cycle-dependent regulation of tumor cells
Masahiko Shibazaki, Chihaya Maesawa, Kiyomi Akasaka, Shuya Kasai, Shinji Yasuhira, Kiminori Kanno, Ikue Nakayama, Toru Sugiyama, Go Wakabayasi, Tomoyuki Masuda, Nozomu Mori
INTERNATIONAL JOURNAL OF ONCOLOGY 40 ( 3 ) 695 - 702 2012.3
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Correlation of dysfunction of nonmuscle myosin IIA with increased induction of Cyp1a1 in Hepa-1 cells
Masayuki Ebina, Masahiko Shibazaki, Kyoko Kudo, Shuya Kasai, Hideaki Kikuchi
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1809 ( 3 ) 176 - 183 2011.3
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Hepa-1細胞における非筋細胞ミオシンIIAの阻害または喪失はTCDDによるCyp1a1誘導を促進する(Inhibition or depletion of Nonmuscle myosin IIA leads to enhancement of Cyp1a1 induction by TCDD in Hepa-1 cells)
蝦名 真行, 柴崎 晶彦, 工藤 恭子, 葛西 秋宅, 菊池 英明
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 83回・33回 1P - 0676 2010.12
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The Inhibitory Mechanisms of the Tyrosine Kinase Inhibitors Herbimycin A, Genistein, and Tyrphostin B48 with Regard to the Function of the Aryl Hydrocarbon Receptor in Caco-2 Cells
Shuya Kasai, Hideaki Kikuchi
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 74 ( 1 ) 36 - 43 2010.1
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Calcium/calmodulin signaling elicits release of cytochrome c during 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptosis in the human lymphoblastic T-cell line, L-MAT
Daisuke Kobayashi, Sohel Ahmed, Masato Ishida, Shuya Kasai, Hideaki Kikuchi
TOXICOLOGY 258 ( 1 ) 25 - 32 2009.4