研究者詳細 - 葛西　秋宅

論文 - 葛西　秋宅

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Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study.

Shimizu S, Kasai S, Suzuki C, Kon T, Suganuma H, Suzuki S, Murashita K, Nakaji S, Ihara K, Tomiyama M, Itoh K

Frontiers in nutrition 13 1740494 2026年

Mitochondrial Reactive Oxygen Species, Insulin Resistance, and Nrf2-Mediated Oxidative Stress Response-Toward an Actionable Strategy for Anti-Aging.

Kasai S, Kokubu D, Mizukami H, Itoh K

Biomolecules 13 ( 10 ) 2023年10月

Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage

Jun Liu, Shuya Kasai, Yota Tatara, Hiromi Yamazaki, Junsei Mimura, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Kunikazu Tanji, Koichi Wakabayashi, Hayato Maeda, Hiroki Mizukami, Yasuhiro Shinkai, Yoshito Kumagai, Hirofumi Tomita and Ken Itoh

International Journal of Molecular Sciences 2022年03月

Multi-marker discovery for mild cognitive impairment in metabolomics using machine learning with a global surrogate model via partial least squares.

Tatara Y, Yamamoto H, Terai K, Matsuta R, Kasai S, Tamada Y, Mikami T, Murashita K, Itoh K

Metabolomics : Official journal of the Metabolomic Society 21 ( 6 ) 164 2025年11月

Spatial colocalization and molecular crosstalk of myofibroblastic CAFs and tumor cells shape lymph node metastasis in oral squamous cell carcinoma.

Furudate K, Kasai S, Yoshizawa T, Sasaki Y, Fujikura K, Goto S, Ito R, Takagi K, Tanaka T, Kijima H, Kubota K, Itoh K, Kobayashi W, Takahashi K

PLoS genetics 21 ( 9 ) e1011791 2025年09月

Intranasal administration of ergothioneine improves memory in a mouse model of multiple system atrophy.

Kimura K, Tanaka MT, Miki Y, Furukawa T, Kasai S, Ozaki T, Mori F, Shibuya E, Wakabayashi K

Biochemical and biophysical research communications 756 151550 - 151550 2025年02月

Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages.

Aoyama Y, Yamazaki H, Nishimura K, Nomura M, Shigehiro T, Suzuki T, Zang W, Tatara Y, Ito H, Hayashi Y, Koike Y, Fukumoto M, Tanaka A, Zhang Y, Saika W, Hasegawa C, Kasai S, Kong Y, Minakuchi Y, Itoh K, Yamamoto M, Toyokuni S, Toyoda A, Ikawa T, Takaori-Kondo A, Inoue D

Blood 145 ( 11 ) 1149 - 1163 2025年01月

Association between NF-E2-related factor 2 polymorphism and age-related hearing loss in the general Japanese population from the Iwaki health promotion project.

Kasai T, Sasaki A, Kasai S, Miura S, Goto S, Yotsuyanagi R, Mikami T, Tamada Y, Itoh K, Matsubara A

Acta oto-laryngologica 145 ( 1 ) 1 - 7 2024年12月

Emerging Role of GCN1 in Disease and Homeostasis.

Tatara Y, Kasai S, Kokubu D, Tsujita T, Mimura J, Itoh K

International journal of molecular sciences 25 ( 5 ) 2024年03月

未病制御におけるNrf2酸化ストレス応答機構の役割とその分子機構

伊東健, 葛西秋宅, 多田羅洋太

化学と生物 62 ( 3 ) 145 - 153 2024年03月

Altered structural hippocampal intra-networks in a general elderly Japanese population with mild cognitive impairment.

Kasai S, Watanabe K, Umemura Y, Ishimoto Y, Sasaki M, Nagaya H, Tatsuo S, Mikami T, Tamada Y, Ide S, Tomiyama M, Matsuzaka M, Kakeda S

Scientific reports 13 ( 1 ) 13330 2023年08月

Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation.

Inose-Maruyama A, Kasai S, Itoh K

Methods in molecular biology (Clifton, N.J.) 2651 157 - 166 2023年

Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment

Yota Tatara, Hiromi Yamazaki, Fumiki Katsuoka, Mitsuru Chiba, Daisuke Saigusa, Shuya Kasai, Tomohiro Nakamura, Jin Inoue, Yuichi Aoki, Miho Shoji, Ikuko N Motoike, Yoshinori Tamada, Katsuhito Hashizume, Mikio Shoji, Kengo Kinoshita, Koichi Murashita, Shigeyuki Nakaji, Masayuki Yamamoto, Ken Itoh

Current research in translational medicine 71 ( 1 ) 103367 - 103367 2022年10月

Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice.

Shimizu S, Kasai S, Yamazaki H, Tatara Y, Mimura J, Engler MJ, Tanji K, Nikaido Y, Inoue T, Suganuma H, Wakabayashi K, Itoh K

International journal of molecular sciences 23 ( 15 ) 2022年07月

Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage.

Liu J, Kasai S, Tatara Y, Yamazaki H, Mimura J, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Tanji K, Wakabayashi K, Maeda H, Mizukami H, Shinkai Y, Kumagai Y, Tomita H, Itoh K

International journal of molecular sciences 23 ( 6 ) 3201 - 3201 2022年03月

Association of mitochondrial DNA haplogroup and hearing impairment with aging in Japanese general population of the Iwaki Health Promotion Project.

Miura S, Sasaki A, Kasai S, Sugawara T, Maeda Y, Goto S, Kasai T, Shimizume N, Jung S, Iwane T, Itoh K, Matsubara A

Journal of human genetics 67 ( 6 ) 369 - 375 2022年01月

Direct protein–protein interaction between Npas4 and IPAS mutually inhibits their critical roles in neuronal cell survival and death

Shuya Kasai, Xianyu Li, Satoru Torii, Ken-ichi Yasumoto and Kazuhiro Sogawa

Cell Death Discovery 2021年10月

多層オミックスと機械学習による軽度認知障害の予測モデルの構築

多田羅洋太, 中村智洋, 千葉満, 三枝大輔, 山嵜博未, 勝岡史城, 葛西秋宅, 川瀬倫子, 本間リナ, 松田りら, 藤本哲太, 荘司美穂, 元池育子, 玉田嘉紀, 橋爪克仁, 東海林幹夫, 木下賢吾, 伊東健

Dementia Japan 35 ( 4 ) 660 - 660 2021年10月

Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis.

Sugawara M, Abe T, Kasai S, Itoh K, Ozaki T

Biochemistry and biophysics reports 27 101101 - 101101 2021年08月

Attenuation of inhibitory PAS domain protein-induced cell death by synthetic peptides derived from Mcl-1 transmenbrane domain.

Kasai S, Yasumoto KI, Sogawa K

Cell death discovery 7 ( 1 ) 92 2021年05月

The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress.

Dorion MF, Mulumba M, Kasai S, Itoh K, Lubell WD, Ong H

Oxidative medicine and cellular longevity 2021 6691402 2021年03月

Nrf2とATF4の相互作用を基盤にした未病気における疾患予防法の開発

葛西秋宅

BIO Clinica 36 80 - 84 2021年

特集慢性腎臓病・透析患者の酸化ストレス-最新知見と治療展開 2.慢性腎臓病における酸化ストレス進展機序(1) 慢性腎臓病におけるNrf2-Keap1 経路の役割-CKD 治療薬としての期待

伊東健, Liu Jun, 葛西秋宅

臨床透析 36 ( 12 ) 1521 - 1527 2020年11月

Correction to: Prevalence of the mitochondrial 1555 A>G and 1494 C>T mutations in a community-dwelling population in Japan.

Maeda Y, Sasaki A, Kasai S, Goto S, Nishio SY, Sawada K, Tokuda I, Itoh K, Usami SI, Matsubara A

Human genome variation 7 ( 1 ) 27 - 27 2020年10月

Prevalence of the mitochondrial 1555 A>G and 1494 C>T mutations in a community-dwelling population in Japan.

Maeda Y, Sasaki A, Kasai S, Goto S, Nishio SY, Sawada K, Tokuda I, Itoh K, Usami SI, Matsubara A.

Hum Genome Var. 2020年09月

Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging.

Shimizu S, Mimura J, Hasegawa T, Shimizu E, Imoto S, Tsushima M, Kasai S, Yamazaki H, Ushida Y, Suganuma H, Tomita H, Yamamoto M, Nakaji S, Itoh K.

PLoS One. 2020年08月

多層オミックス解析による認知症の早期発見のためのバイオマーカー探索

多田羅洋太, 中村智洋, 山嵜博未, 勝岡史城, 千葉満, 三枝大輔, 葛西秋宅, 伊東健

JSBMS Letters 45 ( Suppl. ) 32 - 32 2020年08月

Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging.

Shimizu S, Mimura J, Hasegawa T, Shimizu E, Imoto S, Tsushima M, Kasai S, Yamazaki H, Ushida Y, Suganuma H, Tomita H, Yamamoto M, Nakaji S, Itoh K

PloS one 15 ( 8 ) e0236834 2020年08月

Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.

Yamazaki H, Kasai S, Mimura J, Ye P, Inose-Maruyama A, Tanji K, Wakabayashi K, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Cavener DR, Yamamoto M, Itoh K

PLoS genetics 16 ( 4 ) e1008693 2020年04月

Mitochondrial E3 Ubiquitin Ligase Parkin: Relationships with Other Causal Proteins in Familial Parkinson's Disease and Its Substrate-Involved Mouse Experimental Models.

Torii S, Kasai S, Yoshida T, Yasumoto KI, Shimizu S

International journal of molecular sciences 21 ( 4 ) 1202 - 1202 2020年02月

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology.

Kasai S, Shimizu S, Tatara Y, Mimura J, Itoh K

Biomolecules 10 ( 2 ) 320 - 320 2020年02月

ストレス応答性転写因子Nrf2とATF4の相互作用を基盤にした疾患予防・アンチエイジング法の開発

葛西秋宅

BIO Clinica 35 60 - 64 2020年

Deficiency of P62/SQSTM1 Exacerbates Doxorubicin-Induced Cardiac Dysfunction

Michiko Tsushima, Junsei Mimura, Jun Liu, Hiromi Yamazaki, Shuya Kasai, Hirofumi Tomita, Ken Itoh

CIRCULATION 140 2019年11月

Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes.

Junsei Mimura, Atsushi Inose-Maruyama, Shusuke Taniuchi, Kunio Kosaka, Hidemi Yoshida, Hiromi Yamazaki, Shuya Kasai, Nobuhiko Harada, Randal J Kaufman, Seiichi Oyadomari, Ken Itoh

International journal of molecular sciences 20 ( 7 ) 1706 2019年04月

Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control.

Kasai S, Yamazaki H, Tanji K, Engler MJ, Matsumiya T, Itoh K

Journal of clinical biochemistry and nutrition 64 ( 1 ) 1 - 12 2019年01月

Deficiency of protein-L-isoaspartate (D-aspartate) O-methyl-transferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma.

Masahiro Yamashita, Masahito Ogasawara, Yasushi Kawasaki, Miyuki Niisato, Heisuke Saito, Shuya Kasai, Chihaya Maesawa, Makoto Maemondo, Kohei Yamauchi

Oncotarget 9 ( 17 ) 13287 - 13300 2018年03月

Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease.

Shuya Kasai, Junsei Mimura, Taku Ozaki, Ken Itoh

Frontiers in veterinary science 5 242 - 242 2018年

Increase in proapoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2.

Shuya Kasai, Mary J E Richardson, Satoru Torii, Ken-Ichi Yasumoto, Hiroki Shima, Kazuhiko Igarashi, Ken Itoh, Kazuhiro Sogawa, Kazutaka Murayama

The FEBS journal 284 ( 23 ) 4115 - 4127 2017年12月

Bcl-2/Bcl-xL inhibitor ABT-737 sensitizes pancreatic ductal adenocarcinoma to paclitaxel-induced cell death.

Shuya Kasai, Takuya Sasaki, Ayano Watanabe, Masao Nishiya, Shinji Yasuhira, Masahiko Shibazaki, Chihaya Maesawa

Oncology letters 14 ( 1 ) 903 - 908 2017年07月

Conformational changes in inhibitory PAS domain protein associated with binding of HIF-1α and Bcl-xL in living cells.

Shuya Kasai, Shinji Kajimoto, Yuma Ito, Tomo Saito, Ken-Ichi Yasumoto, Makio Tokunaga, Kumiko Sakata-Sogawa, Hiroshi Fukumura, Kazuhiro Sogawa

Journal of biochemistry 161 ( 3 ) 291 - 296 2017年03月

NAD(P)H: Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG

Shuya Kasai, Nobuyuki Arakawa, Ayaka Okubo, Wataru Shigeeda, Shinji Yasuhira, Tomoyuki Masuda, Toshihide Akasaka, Masahiko Shibazaki, Chihaya Maesawa

PLOS ONE 11 ( 4 ) e0153181 2016年04月

Temporal expression in rats of receptor tyrosine kinase Tie2 during early wound healing after tooth extraction

Hirotaka Sato, Shuya Kasai, Chihaya Maesawa

JOURNAL OF ORAL SCIENCE 57 ( 4 ) 313 - 318 2015年12月

Inhibitory PAS domain protein is a substrate of PINK1 and Parkin and mediates cell death in a Parkinson's disease model.

S Kasai, S Torii, A Kakita, K Sogawa

Cell death & disease 6 e1886 - e1886 2015年09月

Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification.

Yoshinori Tatemichi, Masahiko Shibazaki, Shinji Yasuhira, Shuya Kasai, Hiroshi Tada, Hiroki Oikawa, Yuji Suzuki, Yasuhiro Takikawa, Tomoyuki Masuda, Chihaya Maesawa

Cancer science 106 ( 7 ) 848 - 856 2015年07月

Temporal expression in rats of receptor tyrosine kinase Tie2 during early wound healing after tooth extraction.

Hirotaka Sato, Shuya Kasai, Chihaya Maesawa

Journal of oral science 57 ( 4 ) 313 - 318 2015年

Involvement of inhibitory PAS domain protein in neuronal cell death in Parkinson's disease.

Torii S, Kasai S, Suzuki A, Todoroki Y, Yokozawa K, Yasumoto KI, Seike N, Kiyonari H, Mukumoto Y, Kakita A, Sogawa K

Cell death discovery 1 15015 2015年

Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.

Shinpei Miura, Chihaya Maesawa, Masahiko Shibazaki, Shinji Yasuhira, Syuya Kasai, Kanako Tsunoda, Fumihiko Maeda, Kazuhiro Takahashi, Toshihide Akasaka, Tomoyuki Masuda

The American Journal of dermatopathology 36 ( 3 ) 211 - 216 2014年03月

A somatic mutation of the KEAP1 gene in malignant melanoma is involved in aberrant NRF2 activation and an increase in intrinsic drug resistance.

Shinpei Miura, Masahiko Shibazaki, Shuya Kasai, Shinji Yasuhira, Ayano Watanabe, Tsuyoshi Inoue, Yuich Kageshita, Kanako Tsunoda, Kazuhiro Takahashi, Toshihide Akasaka, Tomoyuki Masuda, Chihaya Maesawa

The Journal of investigative dermatology 134 ( 2 ) 553 - 556 2014年02月

Dephosphorylation of Sp1 at Ser-59 by protein phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole.

Shuji Shimoyama, Shuya Kasai, Brigitte Kahn-Perlès, Hideaki Kikuchi

Biochimica et biophysica acta 1839 ( 2 ) 107 - 115 2014年02月

BCL2 and BCLxL are key determinants of resistance to antitubulin chemotherapeutics in melanoma cells

Ayano Watanabe, Shinji Yasuhira, Tsuyoshi Inoue, Shuya Kasai, Masahiko Shibazaki, Kazuhiro Takahashi, Toshihide Akasaka, Tomoyuki Masuda, Chihaya Maesawa

EXPERIMENTAL DERMATOLOGY 22 ( 8 ) 518 - 523 2013年08月

Beta-catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells.

Kasai S, Ishigaki T, Takumi R, Kamimura T, Kikuchi H

Biochimica et biophysica acta 1830 ( 3 ) 2509 - 2516 2013年03月

Transcriptional and post-transcriptional regulation of βIII-tubulin protein expression in relation with cell cycle-dependent regulation of tumor cells.

Shibazaki M, Maesawa C, Akasaka K, Kasai S, Yasuhira S, Kanno K, Nakayama I, Sugiyama T, Wakabayasi G, Masuda T, Mori N

International journal of oncology 40 ( 3 ) 695 - 702 2012年03月

Correlation of dysfunction of nonmuscle myosin IIA with increased induction of Cyp1a1 in Hepa-1 cells

Masayuki Ebina, Masahiko Shibazaki, Kyoko Kudo, Shuya Kasai, Hideaki Kikuchi

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1809 ( 3 ) 176 - 183 2011年03月

Hepa-1細胞における非筋細胞ミオシンIIAの阻害または喪失はTCDDによるCyp1a1誘導を促進する(Inhibition or depletion of Nonmuscle myosin IIA leads to enhancement of Cyp1a1 induction by TCDD in Hepa-1 cells)

蝦名真行, 柴崎晶彦, 工藤恭子, 葛西秋宅, 菊池英明

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 83回・33回 1P - 0676 2010年12月

The Inhibitory Mechanisms of the Tyrosine Kinase Inhibitors Herbimycin A, Genistein, and Tyrphostin B48 with Regard to the Function of the Aryl Hydrocarbon Receptor in Caco-2 Cells

Shuya Kasai, Hideaki Kikuchi

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 74 ( 1 ) 36 - 43 2010年01月

Calcium/calmodulin signaling elicits release of cytochrome c during 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptosis in the human lymphoblastic T-cell line, L-MAT

Daisuke Kobayashi, Sohel Ahmed, Masato Ishida, Shuya Kasai, Hideaki Kikuchi

TOXICOLOGY 258 ( 1 ) 25 - 32 2009年04月

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