論文 - 葛西 秋宅
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Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage
Jun Liu, Shuya Kasai, Yota Tatara, Hiromi Yamazaki, Junsei Mimura, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Kunikazu Tanji, Koichi Wakabayashi, Hayato Maeda, Hiroki Mizukami, Yasuhiro Shinkai, Yoshito Kumagai, Hirofumi Tomita and Ken Itoh
International Journal of Molecular Sciences 2022年03月
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Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology.
Kasai S, Shimizu S, Tatara Y, Mimura J, Itoh K
Biomolecules 10 ( 2 ) 320 - 320 2020年02月
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Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control.
Kasai S, Yamazaki H, Tanji K, Engler MJ, Matsumiya T, Itoh K
Journal of clinical biochemistry and nutrition 64 ( 1 ) 1 - 12 2019年01月
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Emerging Role of GCN1 in Disease and Homeostasis.
Tatara Y, Kasai S, Kokubu D, Tsujita T, Mimura J, Itoh K
International journal of molecular sciences 25 ( 5 ) 2024年03月
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Mitochondrial Reactive Oxygen Species, Insulin Resistance, and Nrf2-Mediated Oxidative Stress Response-Toward an Actionable Strategy for Anti-Aging.
Kasai S, Kokubu D, Mizukami H, Itoh K
Biomolecules 13 ( 10 ) 2023年10月
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Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation.
Inose-Maruyama A, Kasai S, Itoh K
Methods in molecular biology (Clifton, N.J.) 2651 157 - 166 2023年
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Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment
Yota Tatara, Hiromi Yamazaki, Fumiki Katsuoka, Mitsuru Chiba, Daisuke Saigusa, Shuya Kasai, Tomohiro Nakamura, Jin Inoue, Yuichi Aoki, Miho Shoji, Ikuko N Motoike, Yoshinori Tamada, Katsuhito Hashizume, Mikio Shoji, Kengo Kinoshita, Koichi Murashita, Shigeyuki Nakaji, Masayuki Yamamoto, Ken Itoh
71 ( 1 ) 103367 2022年10月
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Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice.
Shimizu S, Kasai S, Yamazaki H, Tatara Y, Mimura J, Engler MJ, Tanji K, Nikaido Y, Inoue T, Suganuma H, Wakabayashi K, Itoh K
International journal of molecular sciences 23 ( 15 ) 2022年07月
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Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage.
Liu J, Kasai S, Tatara Y, Yamazaki H, Mimura J, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Tanji K, Wakabayashi K, Maeda H, Mizukami H, Shinkai Y, Kumagai Y, Tomita H, Itoh K
International journal of molecular sciences 23 ( 6 ) 3201 - 3201 2022年03月
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Association of mitochondrial DNA haplogroup and hearing impairment with aging in Japanese general population of the Iwaki Health Promotion Project.
Miura S, Sasaki A, Kasai S, Sugawara T, Maeda Y, Goto S, Kasai T, Shimizume N, Jung S, Iwane T, Itoh K, Matsubara A
Journal of human genetics 67 ( 6 ) 369 - 375 2022年01月
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Direct protein–protein interaction between Npas4 and IPAS mutually inhibits their critical roles in neuronal cell survival and death
Shuya Kasai, Xianyu Li, Satoru Torii, Ken-ichi Yasumoto and Kazuhiro Sogawa
Cell Death Discovery 2021年10月
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多層オミックスと機械学習による軽度認知障害の予測モデルの構築
多田羅 洋太, 中村 智洋, 千葉 満, 三枝 大輔, 山嵜 博未, 勝岡 史城, 葛西 秋宅, 川瀬 倫子, 本間 リナ, 松田 りら, 藤本 哲太, 荘司 美穂, 元池 育子, 玉田 嘉紀, 橋爪 克仁, 東海林 幹夫, 木下 賢吾, 伊東 健
Dementia Japan 35 ( 4 ) 660 - 660 2021年10月
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Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis.
Sugawara M, Abe T, Kasai S, Itoh K, Ozaki T
Biochemistry and biophysics reports 27 101101 - 101101 2021年08月
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Attenuation of inhibitory PAS domain protein-induced cell death by synthetic peptides derived from Mcl-1 transmenbrane domain.
Kasai S, Yasumoto KI, Sogawa K
Cell death discovery 7 ( 1 ) 92 2021年05月
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The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress.
Dorion MF, Mulumba M, Kasai S, Itoh K, Lubell WD, Ong H
Oxidative medicine and cellular longevity 2021 6691402 2021年03月
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Nrf2とATF4の相互作用を基盤にした未病気における疾患予防法の開発
葛西 秋宅
BIO Clinica 36 80 - 84 2021年
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特集 慢性腎臓病・透析患者の酸化ストレス-最新知見と治療展開 2.慢性腎臓病における酸化ストレス進展機序(1) 慢性腎臓病におけるNrf2-Keap1 経路の役割-CKD 治療薬としての期待
伊東 健, Liu Jun, 葛西 秋宅
臨床透析 36 ( 12 ) 1521 - 1527 2020年11月
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Correction to: Prevalence of the mitochondrial 1555 A>G and 1494 C>T mutations in a community-dwelling population in Japan.
Maeda Y, Sasaki A, Kasai S, Goto S, Nishio SY, Sawada K, Tokuda I, Itoh K, Usami SI, Matsubara A
Human genome variation 7 ( 1 ) 27 - 27 2020年10月
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Prevalence of the mitochondrial 1555 A>G and 1494 C>T mutations in a community-dwelling population in Japan.
Maeda Y, Sasaki A, Kasai S, Goto S, Nishio SY, Sawada K, Tokuda I, Itoh K, Usami SI, Matsubara A.
Hum Genome Var. 2020年09月
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Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging.
Shimizu S, Mimura J, Hasegawa T, Shimizu E, Imoto S, Tsushima M, Kasai S, Yamazaki H, Ushida Y, Suganuma H, Tomita H, Yamamoto M, Nakaji S, Itoh K.
PLoS One. 2020年08月