論文 - 葛西 秋宅
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Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study.
Shimizu S, Kasai S, Suzuki C, Kon T, Suganuma H, Suzuki S, Murashita K, Nakaji S, Ihara K, Tomiyama M, Itoh K
Frontiers in nutrition 13 1740494 2026年
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Mitochondrial Reactive Oxygen Species, Insulin Resistance, and Nrf2-Mediated Oxidative Stress Response-Toward an Actionable Strategy for Anti-Aging.
Kasai S, Kokubu D, Mizukami H, Itoh K
Biomolecules 13 ( 10 ) 2023年10月
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Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage
Jun Liu, Shuya Kasai, Yota Tatara, Hiromi Yamazaki, Junsei Mimura, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Kunikazu Tanji, Koichi Wakabayashi, Hayato Maeda, Hiroki Mizukami, Yasuhiro Shinkai, Yoshito Kumagai, Hirofumi Tomita and Ken Itoh
International Journal of Molecular Sciences 2022年03月
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Multi-marker discovery for mild cognitive impairment in metabolomics using machine learning with a global surrogate model via partial least squares.
Tatara Y, Yamamoto H, Terai K, Matsuta R, Kasai S, Tamada Y, Mikami T, Murashita K, Itoh K
Metabolomics : Official journal of the Metabolomic Society 21 ( 6 ) 164 2025年11月
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Spatial colocalization and molecular crosstalk of myofibroblastic CAFs and tumor cells shape lymph node metastasis in oral squamous cell carcinoma.
Furudate K, Kasai S, Yoshizawa T, Sasaki Y, Fujikura K, Goto S, Ito R, Takagi K, Tanaka T, Kijima H, Kubota K, Itoh K, Kobayashi W, Takahashi K
PLoS genetics 21 ( 9 ) e1011791 2025年09月
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Intranasal administration of ergothioneine improves memory in a mouse model of multiple system atrophy.
Kimura K, Tanaka MT, Miki Y, Furukawa T, Kasai S, Ozaki T, Mori F, Shibuya E, Wakabayashi K
Biochemical and biophysical research communications 756 151550 - 151550 2025年02月
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Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages.
Aoyama Y, Yamazaki H, Nishimura K, Nomura M, Shigehiro T, Suzuki T, Zang W, Tatara Y, Ito H, Hayashi Y, Koike Y, Fukumoto M, Tanaka A, Zhang Y, Saika W, Hasegawa C, Kasai S, Kong Y, Minakuchi Y, Itoh K, Yamamoto M, Toyokuni S, Toyoda A, Ikawa T, Takaori-Kondo A, Inoue D
Blood 145 ( 11 ) 1149 - 1163 2025年01月
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Association between NF-E2-related factor 2 polymorphism and age-related hearing loss in the general Japanese population from the Iwaki health promotion project.
Kasai T, Sasaki A, Kasai S, Miura S, Goto S, Yotsuyanagi R, Mikami T, Tamada Y, Itoh K, Matsubara A
Acta oto-laryngologica 145 ( 1 ) 1 - 7 2024年12月
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Emerging Role of GCN1 in Disease and Homeostasis.
Tatara Y, Kasai S, Kokubu D, Tsujita T, Mimura J, Itoh K
International journal of molecular sciences 25 ( 5 ) 2024年03月
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未病制御におけるNrf2酸化ストレス応答機構の役割とその分子機構
伊東 健, 葛西 秋宅, 多田羅 洋太
化学と生物 62 ( 3 ) 145 - 153 2024年03月
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Altered structural hippocampal intra-networks in a general elderly Japanese population with mild cognitive impairment.
Kasai S, Watanabe K, Umemura Y, Ishimoto Y, Sasaki M, Nagaya H, Tatsuo S, Mikami T, Tamada Y, Ide S, Tomiyama M, Matsuzaka M, Kakeda S
Scientific reports 13 ( 1 ) 13330 2023年08月
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Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation.
Inose-Maruyama A, Kasai S, Itoh K
Methods in molecular biology (Clifton, N.J.) 2651 157 - 166 2023年
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Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment
Yota Tatara, Hiromi Yamazaki, Fumiki Katsuoka, Mitsuru Chiba, Daisuke Saigusa, Shuya Kasai, Tomohiro Nakamura, Jin Inoue, Yuichi Aoki, Miho Shoji, Ikuko N Motoike, Yoshinori Tamada, Katsuhito Hashizume, Mikio Shoji, Kengo Kinoshita, Koichi Murashita, Shigeyuki Nakaji, Masayuki Yamamoto, Ken Itoh
Current research in translational medicine 71 ( 1 ) 103367 - 103367 2022年10月
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Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice.
Shimizu S, Kasai S, Yamazaki H, Tatara Y, Mimura J, Engler MJ, Tanji K, Nikaido Y, Inoue T, Suganuma H, Wakabayashi K, Itoh K
International journal of molecular sciences 23 ( 15 ) 2022年07月
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Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage.
Liu J, Kasai S, Tatara Y, Yamazaki H, Mimura J, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Tanji K, Wakabayashi K, Maeda H, Mizukami H, Shinkai Y, Kumagai Y, Tomita H, Itoh K
International journal of molecular sciences 23 ( 6 ) 3201 - 3201 2022年03月
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Association of mitochondrial DNA haplogroup and hearing impairment with aging in Japanese general population of the Iwaki Health Promotion Project.
Miura S, Sasaki A, Kasai S, Sugawara T, Maeda Y, Goto S, Kasai T, Shimizume N, Jung S, Iwane T, Itoh K, Matsubara A
Journal of human genetics 67 ( 6 ) 369 - 375 2022年01月
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Direct protein–protein interaction between Npas4 and IPAS mutually inhibits their critical roles in neuronal cell survival and death
Shuya Kasai, Xianyu Li, Satoru Torii, Ken-ichi Yasumoto and Kazuhiro Sogawa
Cell Death Discovery 2021年10月
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多層オミックスと機械学習による軽度認知障害の予測モデルの構築
多田羅 洋太, 中村 智洋, 千葉 満, 三枝 大輔, 山嵜 博未, 勝岡 史城, 葛西 秋宅, 川瀬 倫子, 本間 リナ, 松田 りら, 藤本 哲太, 荘司 美穂, 元池 育子, 玉田 嘉紀, 橋爪 克仁, 東海林 幹夫, 木下 賢吾, 伊東 健
Dementia Japan 35 ( 4 ) 660 - 660 2021年10月
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Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis.
Sugawara M, Abe T, Kasai S, Itoh K, Ozaki T
Biochemistry and biophysics reports 27 101101 - 101101 2021年08月
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Attenuation of inhibitory PAS domain protein-induced cell death by synthetic peptides derived from Mcl-1 transmenbrane domain.
Kasai S, Yasumoto KI, Sogawa K
Cell death discovery 7 ( 1 ) 92 2021年05月