Affiliation
Faculty of Agriculture and Life Science Department of Biochemistry and Molecular Biology
External link
HIGICHI Yudai
Degree
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Doctor (Engineering)
Campus Career
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Hirosaki University Faculty of Agriculture and Life Science Department of Biochemistry and Molecular Biology Assistant Professor
2020.04 ～ Now
Research Interests
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物質生産
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リグニン
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代謝
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微生物
Research Areas
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Life Science / Applied microbiology
Professional Memberships
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日本生物工学会
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リグニン学会
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日本農芸化学会
Papers
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Successful selective production of vanillic acid from depolymerized sulfite lignin and its application to poly(ethylene vanillate) synthesis
Yudai Higuchi,Hiroya Ishimaru,Takuya Yoshikawa,Takao Masuda,Chiho Sakamoto,Naofumi Kamimura,Eiji Masai,Daisuke Takeuchi,Tomonori Sonoki
Bioresource Technology 385 129450 2023.10
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The Catabolic System of Acetovanillone and Acetosyringone in Sphingobium sp. Strain SYK-6 Useful for Upgrading Aromatic Compounds Obtained through Chemical Lignin Depolymerization.
Yudai Higuchi, Naofumi Kamimura, Hiroki Takenami, Yusei Kikuiri, Chieko Yasuta, Kenta Tanatani, Toru Shobuda, Yuichiro Otsuka, Masaya Nakamura, Tomonori Sonoki, Eiji Masai
Applied and Environmental Microbiology 2022.8
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Engineering a vanillate-producing strain of Pseudomonas sp. NGC7 corresponding to aromatic compounds derived from the continuous catalytic alkaline oxidation of sulfite lignin
Microbial Cell Factories 23 ( 313 ) 1 - 12 2024.11
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Direct catalytic oxidation of rice husk lignin with hydroxide nanorod-modified copper foam and muconate production by engineered Pseudomonas sp. NGC7
Akihiro Yoshida, Irwan Kurnia, Yudai Higuchi, Yuta Osaka, Chieko Yasuta, Chiho Sakamoto, Mina Tamura, Tsubasa Takamatsu, Naofumi Kamimura, Eiji Masai, Tomonori Sonoki
Journal of Bioscience and Bioengineering 138 ( 5 ) 431 - 438 2024.8
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Direct extraction of biphasic organosolv lignin for producing aromatic aldehydes via alkaline oxidation
Hiroya Ishimaru, Takuya Yoshikawa, Yudai Higuchi, Yuta Nakasaka, Akihiro Yoshida, Tomonori Sonoki, Takao Masuda
Journal of the Taiwan Institute of Chemical Engineers 158 105009 - 105009 2024.5
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Catabolic system of 5-formylferulic acid, a downstream metabolite of a β-5-type lignin-derived dimer, in Sphingobium lignivorans SYK-6.
Mitsuru Kawazoe,Kenji Takahashi,Yosuke Tokue,Shojiro Hishiyama,Hayato Seki,Yudai Higuchi,Naofumi Kamimura,Eiji Masai
Journal of Agricultural and Food Chemistry 71 ( 49 ) 19663 - 19671 2023.12
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Stereoinversion via alcohol dehydrogenases enables complete catabolism of β-1-type lignin-derived aromatic Isomers.
Ryo Kato,Kodai Maekawa,Shota Kobayashi,Shojiro Hishiyama,Rui Katahira,Miki Nambo,Yudai Higuchi,Eugene Kuatsjah,Gregg T Beckham,Naofumi Kamimura,Eiji Masai
Applied and Environmental Microbiology 89 ( 6 ) e00171-23 2023.6
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Pseudomonas sp. NGC7 as a microbial chassis for glucose-free muconate production from a variety of lignin-derived aromatics and its application to the production from sugar cane bagasse alkaline extract.
Miho Akutsu, Nanase Abe, Chiho Sakamoto, Yuki Kurimoto, Haruka Sugita, Makoto Tanaka, Yudai Higuchi, Kimitoshi Sakamoto, Naofumi Kamimura, Hiroyuki Kurihara, Eiji Masai, Tomonori Sonoki
2022.6
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LsdD has a critical role in the dehydrodiconiferyl alcohol catabolism among eight lignostilbene α,β-dioxygenase isozymes in Sphingobium sp. strain SYK-6.
Naofumi Kamimura, Yusaku Hirose, Ryuto Masuba, Ryo Kato, Kenji Takahashi, Yudai Higuchi, Shojiro Hishiyama, Eiji Masai
International Biodeterioration & Biodegradation 159 105208 2021.3
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Roles of two glutathione S-transferases in the final step of the β-aryl ether cleavage pathway in Sphingobium sp. strain SYK-6
Yudai Higuchi, Daisuke Sato, Naofumi Kamimura, Eiji Masai
Scientific Reports 10 ( 1 ) 20614 2020.11
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Discovery of novel enzyme genes involved in the conversion of an arylglycerol-β-aryl ether metabolite and their use in generating a metabolic pathway for lignin valorization.
Yudai Higuchi, Ryo Kato, Koichiro Tsubota, Naofumi Kamimura, Nicholas J. Westwood, Eiji Masai
Metabolic Engineering 55 258 - 267 2019.9
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Bacterial catabolism of β-hydroxypropiovanillone and β-hydroxypropiosyringone produced in the reductive cleavage of arylglycerol-β-aryl ether in lignin.
Yudai Higuchi, Shogo Aoki, Hiroki Takenami, Naofumi Kamimura, Kenji Takahashi, Shojiro Hishiyama, Christopher S. Lancefield, Stephen Ojo, Yoshihiro Katayama, Nicholas J. Westwood, Eiji Masai
Applied and Environmental Microbiology 84 ( 7 ) e2670 - 17 2018.4
Books
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Lignin valorization: emerging approaches
Yudai Higuchi, Kenji Takahashi, Naofumi Kamimura, Eiji Masai（ Role： Contributor , Chapter 9: Bacterial enzymes for the cleavage of lignin β-aryl ether bonds: properties and applications）
The Royal Society of Chemistry 2018.4
Review Papers
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化学とバイオが連携したリグニンからの芳香族ポリマー合成
園木 和典，樋口 雄大，吉川 琢也，上村 直史，竹内 大介，政井 英司
月刊BIO INDUSTRY 40 ( 6 ) 26 - 31 2023.6
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シリーズ:大学・官公庁研究機関の研究室紹介(150)弘前大学農学生命科学部分子生命科 学科応用微生物学・微生物代謝機能学研究室
園木 和典，樋口 雄大
紙パ技協誌 77 ( 4 ) 60 - 61 2023.4
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Stereoinversion via alcohol dehydrogenases enables complete catabolism of β-1-type lignin-derived aromatic isomers
Ryo Kato, Kodai Maekawa, Shota Kobayashi, Shojiro Hishiyama, Rui Katahira, Miki Nambo, Yudai Higuchi, Eugene Kuatsjah, Gregg T. Beckham, Naofumi Kamimura, Eiji Masai
bioRxiv 2023.1
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非可食バイオマス活用に向けた弘前大学の微生物工学
園木 和典，樋口 雄大，吉田 曉弘，竹内 大介
日本生物工学会誌「ブランチスピリッツ」 100 ( 12 ) 682 - 683 2022.12
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リグニンからの芳香族ポリマー原料の選択的生産：サルファイトリグニンからのバニリン酸生産へのPseudomonas sp. NGC7株の適用
鎌田 真未, 安田 智恵子, 樋口 雄大, 吉田 曉弘, 坂本 千穂, 大関 さおり, 上村 直史, 政井 英司, 園木 和典
創立100周年記念 第74回日本生物工学会大会 トピックス集 2022.11
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Bacterial catabolic system of acetovanillone and acetosyringone useful for upgrading aromatic compounds obtained through chemical lignin depolymerization
Yudai Higuchi, Naofumi Kamimura, Hiroki Takenami, Yusei Kikuiri, Chieko Yasuta, Kenta Tanatani, Toru Shobuda, Yuichiro Otsuka, Masaya Nakamura, Tomonori Sonoki, Eiji Masai
2022.4
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Roles of two glutathione S-transferases in the final step of the β-aryl ether cleavage pathway in Sphingobium sp. strain SYK-6
Yudai Higuchi, Daisuke Sato, Naofumi Kamimura, Eiji Masai
2020.7
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Bacterial catabolism of lignin-derived aromatics: New findings in a recent decade: Update on bacterial lignin catabolism
Naofumi Kamimura, Kenji Takahashi, Kosuke Mori, Takuma Araki, Masaya Fujita, Yudai Higuchi, Eiji Masai
Environmental Microbiology Reports 9 ( 6 ) 679 - 705 2017.12
Awards
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第57回新潟生化学懇話会 ポスター奨励賞
2016.06