Updated on 2022/01/20

写真a

 
MURAI Yasuhisa
 
Affiliation
Graduate School of Medicine, Endowed Course
Full-time staff
Graduate School of Medicine Endowed Course Community Emergency Medicine
External link

Degree

  • Bachelor (Medicine) M.D.

Research Interests

  • Schlafen11 (SLFN11)

  • Inflammatory bowel disease

  • Gut immunity

  • Gastroenterology

  • Rheumatology and Immunology

  • Cancer biology

Research Areas

  • Life Science / Gastroenterology

  • Life Science / Connective tissue disease and allergy

  • Life Science / Tumor biology

Professional Memberships

  • The Japanese Society of Internal Medicine

  • The Japanese Society of Gastroenterology

  • The Japan Gastroenterological Endoscopy Society

  • Japan College of Rheumatology

  • American Association for Cancer Research ; Active membership

  • The Japan Society of Clinical Immunology

  • The Japanese Gastroenterological Association

  • The Japanese Association for Capsule Endoscopy

  • The Japanese Society of Coloproctology

  • Japanese Society for Inflammatory Bowel Disease

  • The Japanese Society for Mucosal Immunology

  • The Japanese Society of Small Intestinal Disease

  • The Japanese Society of Geriatric Gastroenterology

  • The Japanese Society of Digestion and Absorption

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Papers

  • Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway

    Yasuhisa Murai, Ukhyun Jo, Junko Murai, Shinsaku Fukuda, Naoko Takebe, Yves Pommier

    iScience   24 ( 10 )   103173 - 103173   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    PubMed

  • SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243

    Yasuhisa Murai, Ukhyun Jo, Junko Murai, Lisa M. Jenkins, Shar-Yin N. Huang, Sirisha Chakka, Lu Chen, Ken Cheng, Shinsaku Fukuda, Naoko Takebe, Yves Pommier

    Cancer Research   81 ( 11 )   3067 - 3078   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    PubMed

  • A case of radiotherapy concurrent with S-1 for bleeding at the progressive gastric cancer treated by Ramucirumab and Paclitaxel

    Yasuhisa MURAI , Shohei IGARASHI , Keisuke HASUI , Koji SHIMAYA , Norihiro HANABATA , Kosuke KANAZAWA , Hiroshi NUMAO , Masaki MUNAKATA

    Medical Journal Aomori   61 ( 4 )   149 - 154   2016.12

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    Language:Japanese   Publishing type:Research paper (bulletin of university, research institution)   Kind of work:Joint Work  

  • Endoscopic and histopathologic features of Anti-PD-1-related collagenous colitis

    Hidezumi Kikuchi, Hirotake Sakuraba, Yui Akemoto, Kazuhiro Hosoi, Yasuhisa Murai, Kentaro Hoshi, Yukari Fukutoku, Taka Asari, Yohei Sawada, Keisuke Hasui, Tetsuya Tatsuta, Hiroto Hiraga, Daisuke Chinda, Tatsuya Mikami, Shinsaku Fukuda

    DEN Open   2 ( e92 )   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1–DNA complexes

    Liton Kumar Saha, Yasuhisa Murai, Sourav Saha, Ukhyun Jo, Masataka Tsuda, Shunichi Takeda, Yves Pommier

    Nucleic Acids Research   49 ( 18 )   10493 - 10506   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    PubMed

  • Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11

    Ukhyun Jo, Yasuhisa Murai, Naoko Takebe, Anish Thomas, Yves Pommier

    Cancers   13 ( 18 )   4601 - 4601   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    PubMed

  • Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress and enhances the chemotherapeutic activity of widely used DNA damaging agents

    Ukhyun Jo, Ilya S Senatorov, Astrid Zimmermann, Liton Kumar Saha, Yasuhisa Murai, Se Hyun Kim, Vinodh N. Rajapakse, Fathi Elloumi, Nobuyuki Takahashi, Christopher W. Schultz, Anish Thomas, Frank T. Zenke, Yves Pommier

    Molecular Cancer Therapeutics   20 ( 8 )   1431 - 1441   2021.5

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    PubMed

  • SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

    Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M. Miller Jenkins, Yves Pommier

    Proceedings of the National Academy of Sciences   118 ( 6 )   e2015654118 - e2015654118   2021.2

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    PubMed

  • Cyclosporine protects from intestinal epithelial injury by modulating butyrate uptake via upregulation of membrane monocarboxylate transporter 1 levels.

    Shinji Ota, Hirotake Sakuraba, Hiroto Hiraga, Shukuko Yoshida, Miwa Satake, Yui Akemoto, Nahoko Tanaka, Rina Watanabe, Maeda Takato, Yasuhisa Murai, Kayo Ueno, Takenori Niioka, Makoto Hayakari, Yoh Ishiguro, Shinsaku Fukuda

    Biochemistry and biophysics reports   24   100811 - 100811   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    PubMed

  • Diagnostic approach for patients with unidentified fever according to the classical criteria of fever of unknown origin in the field of autoimmune disorders.

    Rina Watanabe, Hirotake Sakuraba, Hiroto Hiraga, Dai Kishida, Shinji Ota, Keisuke Hasui, Hidezumi Kikuchi, Yui Akemoto, Nahoko Tanaka, Takato Maeda, Yasuhisa Murai, Shukuko Yoshida, Tetsuya Tatsuta, Manabu Sawaya, Daisuke Chinda, Tatsuya Mikami, Yoh Ishiguro, Shinsaku Fukuda

    Immunological medicine   42 ( 4 )   176 - 184   2019.12

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  • Long-term maintenance of the mucosal healing induced by azacitidine therapy in a patient with intestinal Behçet's-like disease accompanied with myelodysplastic syndrome involving trisomy 8.

    Nahoko Tanaka, Hirotake Sakuraba, Hiroto Hiraga, Ko Mayama, Hidezumi Kikuchi, Dai Kishida, Yui Akemoto, Keisuke Hasui, Shinji Ota, Rina Watanabe, Yasuhisa Murai, Takato Maeda, Kosuke Kamata, Tetsuya Tatsuta, Manabu Sawaya, Daisuke Chinda, Tatsuya Mikami, Kazufumi Yamagata, Yoh Ishiguro, Masanori Tanaka, Shinsaku Fukuda

    Immunological medicine   42 ( 3 )   135 - 141   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

  • A case of nivolumab-associated colitis, which relapsed after mucosal healing and was then successfully treated with mesalazine.

    Hidezumi Kikuchi, Hirotake Sakuraba, Yui Akemoto, Yasuhisa Murai, Yukari Fukutoku, Taka Asari, Tetsuya Tatsuta, Keisuke Hasui, Hiroto Hiraga, Manabu Sawaya, Daisuke Chinda, Tatsuya Mikami, Masanori Tanaka, Shinsaku Fukuda

    Immunological medicine   42 ( 1 )   39 - 44   2019.3

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  • Vitamin A deficiency impairs host resistance to Listeria monocytogenes infection through excessive apoptosis of macrophages

    Nahoko Tanaka, Hiroto Hiraga, Hirotake Sakuraba, Yasuhisa Murai, Takato Maeda, Rina Watanabe, Shinji Ota, Yui Akemoto, Keisuke Hasui, Shukuko Yoshida, Krisana Asano, Akio Nakane, Shinsaku Fukuda

    Hirosaki Medical Journal   69 ( 1-4 )   163 - 171   2019.3

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  • Vitamin A Deficiency Impairs Host Resistance to <i>Listeria Monocytogenes</i> Infection Through Excessive Apoptosis of Macrophages

    Tanaka Nahoko, Yoshida Shukuko, Asano Krisana, Murai Yasuhisa, Fukuda Shinsaku, Watanabe Rina, Ota Shinji, Akemoto Yui, Hasui Keisuke

    Hirosaki Medical Journal   69 ( 1-4 )   163 - 171   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work  

    CiNii Research

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Review Papers

  • 今月の主題 炎症性腸疾患の鑑別診断 主題 炎症性腸疾患の画像所見と鑑別診断-びまん性炎症

    菊池 英純, 三上 達也, 櫻庭 裕丈, 平賀 寛人, 蓮井 桂介, 村井 康久, 星 健太郎, 浅利 享, 澤田 洋平, 宮澤 邦昭, 立田 哲也, 珍田 大輔, 澤谷 学, 花畑 憲洋, 明本 由衣, 福田 眞作

    胃と腸   56 ( 12 )   1547 - 1553   2021.11

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Kind of work:Joint Work  

  • 特集 炎症性腸疾患の分子標的治療を総括する Ⅳ.接着分子阻害薬─ ベドリズマブの特性を生かしたIBD 治療

    櫻庭 裕丈, 平賀 寛人, 蓮井 桂介, 菊池 英純, 村井 康久, 川口 章吾, 樋口 直樹, 明本 由衣, 福田 眞作

    INTESTINE   25 ( 3 )   267 - 274   2021.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Kind of work:Single Work  

  • 特集解き明かされる抗酸化ビタミンのパワー ビタミンAと腸管免疫

    平賀 寛人, 田中 奈保子, 渡邊 里奈, 前田 高人, 村井 康久, 蓮井 桂介, 櫻庭 裕丈, 石黒 陽, 福田 眞作

    食と医療   ( 6 )   2018.7

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Kind of work:Joint Work  

Awards

  • 第4回櫻井記念医学研究賞若手奨励賞

    2021.09

  • 日本消化器病学会研修医奨励賞

    2015.02

  • 日本消化器病学会東北支部第198回例会優秀演題賞

    2015.02

Social Activities

  • 第31回青森県リウマチ懇話会(一般口演)

    2021.07.16

  • 第29回青森県リウマチ懇話会(一般口演)

    2018.06.30