研究者詳細 - 水上　浩哉

論文 - 水上　浩哉

分割表示 >> ／全件表示157 件中 1 - 157 件目

RAGE activation in macrophages and development of experimental diabetic polyneuropathy.

Osonoi S, Mizukami H, Takeuchi Y, Sugawa H, Ogasawara S, Takaku S, Sasaki T, Kudoh K, Ito K, Sango K, Nagai R, Yamamoto Y, Daimon M, Yamamoto H, Yagihashi S.

JCI Insight 7 ( 23 ) e160555. 2022年12月

Dual epigenetic changes in diabetes mellitus-associated pancreatic ductal adenocarcinoma correlate with downregulation of E-cadherin and worsened prognosis.

1. Hara Y, Mizukami H, Yamazaki K, Yamada T, Igawa A, Takeuchi Y, Sasaki T, Kushibiki H, Murakami K, Kudoh K, Ishido K, Hakamada K.

J Pathol Clin Res. 9 ( 5 ) 354 - 366. 2023年09月

Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma.

Pan X, Mizukami H, Hara Y, Yamada T, Yamazaki K, Kudoh K, Takeuchi Y, Sasaki T, Kushibiki H, Igawa A, Hakamada K.

J Diabetes Investig. 14 ( 1 ) 132 - 144 2023年01月

Pathological substrate of memory impairment in multiple system atrophy.

Miki Y, Tanji K, Shinnai K, Tanaka MT, Altay F, Foti SC, Strand C, Sasaki T, Kon T, Shimoyama S, Furukawa T, Nishijima H, Yamazaki H, Asi YT, Bettencourt C, Jaunmuktane Z, Tada M, Mori F, Mizukami H, Tomiyama M, Lashuel HA, Lashley T, Kakita A, Ling H, Lees AJ, Holton JL, Warner TT, Wakabayashi K.

Neuropathol Appl Neurobiol. 48 ( 7 ) e12844 2022年12月

The diversity and abundance of gut microbiota are associated with the pain sensation threshold in the Japanese population.

Takeuchi Y, Mizukami H, Kudoh K, Osonoi S, Sasaki T, Kushibiki H, Ogasawara S, Hara Y, Igawa A, Pan X, Yamada T, Yamazaki K, Mikami T, Daimon M, Yagihashi S, Hakamada K, Nakaji S.

Neurobiol Dis. 173 105839. 2022年10月

Perivascular infiltration reflects subclinical lymph node metastasis in invasive lobular carcinoma.

Igawa A, Mizukami H, Kudoh K, Takeuchi Y, Sasaki T, Pan X, Hakamada K.

Virchows Arch. 481 ( 4 ) 533 - 543 2022年10月

Protocol to image and analyze the morphology of mouse peripheral nerves using transmission electron microscopy.

Nakai-Shimoda H, Himeno T, Motegi M, Ozeki N, Inoue R, Hayami T, Miura-Yura E, Yamada Y, Morishita Y, Tsunekawa S, Kato Y, Seino Y, Kondo M, Naruse K, Kato K, Mizukami H, Nakamura J, Kamiya H.

STAR Protoc 3 ( 3 ) 101591 2022年08月

Cumulative autophagy insufficiency in mice leads to progression of β-cell failure.

Suzuki L, Miyatsuka T, Himuro M, Wakabayashi Y, Osonoi S, Miura M, Katahira T, Fujitani Y, Iida H, Mizukami H, Nishida Y, Watada H.

Biochem Biophys Res Commun. 611 38 - 45 2022年06月

糖尿病性神経障害UPDATE:基礎と臨床の融合

水上浩哉，遲野井祥

糖尿病合併症 36 258 - 261 2022年06月

Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage.

Liu J, Kasai S, Tatara Y, Yamazaki H, Mimura J, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Tanji K, Wakabayashi K, Maeda H, Mizukami H, Shinkai Y, Kumagai Y, Tomita H, Itoh K.

Int J Mol Sci. 23 ( 6 ) 3201 2022年03月

Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves.

Nakai-Shimoda H, Himeno T, Okawa T, Miura-Yura E, Sasajima S, Kato M, Yamada Y, Morishita Y, Tsunekawa S, Kato Y, Seino Y, Inoue R, Kondo M, Seino S, Naruse K, Kato K, Mizukami H, Nakamura J, Kamiya H.

iScience. 25 ( 1 ) 103609 2021年12月

A case of dermatofibrosarcoma protuberans with neurofibromatous change.

2021 ( 11 ) rjab472 2021年12月

Islet microangiopathy and augmented β-cell loss in Japanese non-obese type 2 diabetes patients who died of acute myocardial infarction.

4. Takahashi K, Mizukami H, Osonoi S, Takeuchi Y, Kudoh K, Sasaki T, Daimon M, Yagihashi S.

J Diabetes Investig. 12 ( 12 ) 2149 - 2161 2021年12月

Diabetes in Humans Activates Pancreatic Stellate Cells via RAGE in Pancreatic Ductal Adenocarcinoma.

Uchida C, Mizukami H, Hara Y, Saito T, Umetsu S, Igawa A, Osonoi S, Kudoh K, Yamamoto Y, Yamamoto H, Yagihashi S, Hakamada K.

Int J Mol Sci. 22 ( 21 ) 11716 2021年10月

Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice

Takahashi K, Mizukami H, Osonoi S, Ogasawara S, Hara Y, Kudoh K, Takeuchi Y, Sasaki T, Daimon M, Yagihashi S

Neurobiol Dis. 155 105392 2021年07月

MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis.

Diabetes 70 ( 7 ) 1519 - 1535 2021年07月

Detection of nerve enlargement with ultrasound and correlation with skin biopsy findings in painful sensory neuropathy associated with Sjögren's syndrome.

Yoshida T, Nodera H, Kumon Y, Osanai S, Izumi Y, Mizukami H

Modern rheumatology 31 ( 4 ) 849 - 855 2021年07月

Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice.

Takahashi K, Mizukami H, Osonoi S, Ogasawara S, Hara Y, Kudoh K, Takeuchi Y, Sasaki T, Daimon M, Yagihashi S

Neurobiology of disease 155 105392 2021年07月

MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis.

Ikushima YM, Awazawa M, Kobayashi N, Osonoi S, Takemiya S, Kobayashi H, Suwanai H, Morimoto Y, Soeda K, Adachi J, Muratani M, Charron J, Mizukami H, Takahashi N, Ueki K

Diabetes 70 ( 7 ) 1519 - 1535 2021年07月

Islet microangiopathy and augmented β-cell loss in Japanese non-obese type 2 diabetes patients who died of acute myocardial infarction.

Takahashi K, Mizukami H, Osonoi S, Takeuchi Y, Kudoh K, Sasaki T, Daimon M, Yagihashi S

Journal of diabetes investigation 2021年05月

Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice.

1. Nakamura T, Nampei M, Murase T, Satoh E, Akari S, Katoh N, Mizukami H.

Nutr Diabetes 11 ( 1 ) 12 2021年04月

Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice.

Nakamura T, Nampei M, Murase T, Satoh E, Akari S, Katoh N, Mizukami H

Nutrition & diabetes 11 ( 1 ) 12 2021年04月

Pathogenesis and Molecular Treatment Strategies of Diabetic Neuropathy Collateral Glucose-Utilizing Pathways in Diabetic Polyneuropathy.

Mizukami H, Osonoi S

International journal of molecular sciences 22 ( 1 ) 2020年12月

Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population.

Osonoi S, Mizukami H, Itabashi C, Wada K, Kudoh K, Igawa A, Ogasawara S, Ishibashi Y, Daimon M, Yagihashi S, Nakaji S.

Int J Mol Sci. 21 ( 21 ) 8306 2020年11月

Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population.

Osonoi S, Mizukami H, Itabashi C, Wada K, Kudoh K, Igawa A, Ogasawara S, Ishibashi Y, Daimon M, Yagihashi S, Nakaji S

International journal of molecular sciences 21 ( 21 ) 2020年11月

Detection of nerve enlargement with ultrasound and correlation with skin biopsy findings in painful sensory neuropathy associated with Sjögren's syndrome.

Yoshida T, Nodera H, Kumon Y, Osanai S, Izumi Y, Mizukami H.

Mod Rheumatol. 1 - 7 2020年10月

Role of glucosamine in development of diabetic neuropathy independent of the aldose reductase pathway.

Mizukami H, Osonoi S, Takaku S, Yamagishi SI, Ogasawara S, Sango K, Chung S, Yagihashi S.

Brain Commun. 2 ( 2 ) fcaa168 2020年10月

Lipopolysaccharide-binding protein is a distinctive biomarker of abnormal pain threshold in the general Japanese population.

Kudoh K, Mizukami H, Itabashi C, Fuke N, Osonoi S, Takeuchi Y, Wada K, Igawa A, Ogasawara S, Ishibashi Y, Hakamada K, Yagihashi S, Nakaji S

BMJ open diabetes research & care 8 ( 1 ) 2020年10月

糖尿病性神経障害の病期と病態

遅野井　祥、水上浩哉

糖尿病合併症 34 ( 2 ) 262 - 264 2020年07月

Beneficial effects of combination therapy of canagliflozin and teneligliptin on diabetic polyneuropathy and β-cell volume density in spontaneously type 2 diabetic Goto-Kakizaki rats.

Guo D, Mizukami H, Osonoi S, Takahashi K, Ogasawara S, Kudo K, Sasaki T, Yagihashi S

Metabolism: clinical and experimental 107 154232 2020年06月

Biphasic changes in β-cell mass around parturition are accompanied by increased serotonin production.

Takahashi M, Miyatsuka T, Suzuki L, Osonoi S, Himuro M, Miura M, Katahira T, Wakabayashi Y, Fukunaka A, Nishida Y, Fujitani Y, Takeda S, Mizukami H, Itakura A, Watada H

Scientific reports 10 ( 1 ) 4962 2020年03月

Biphasic changes in β-cell mass around parturition are accompanied by increased serotonin production.

Takahashi M, Miyatsuka T, Suzuki L, Osonoi S, Himuro M, Miura M, Katahira T, Wakabayashi Y, Fukunaka A, Nishida Y, Fujitani Y, Takeda S, Mizukami H, Itakura A, Watada H.

Sci Rep. 10 ( 1 ) 4962 2020年03月

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.

Moon JH, Kim YG, Kim K, Osonoi S, Wang S, Saunders DC, Wang J, Yang K, Kim H, Lee J, Jeong JS, Banerjee RR, Kim SK, Wu Y, Mizukami H, Powers AC, German MS, Kim H.

Diabetes. 69 ( 2 ) 205 - 214 2020年02月

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.

Moon JH, Kim YG, Kim K, Osonoi S, Wang S, Saunders DC, Wang J, Yang K, Kim H, Lee J, Jeong JS, Banerjee RR, Kim SK, Wu Y, Mizukami H, Powers AC, German MS, Kim H

Diabetes 69 ( 2 ) 205 - 214 2020年02月

Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation.

Umetsu S, Mizukami H, Saito T, Uchida C, Igawa A, Kudo K, Itabashi C, Osonoi S, Danyang G, Sasaki T, Yagihashi S, Hakamada K

Scientific reports 10 ( 1 ) 1156 2020年01月

Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation.

Umetsu S, Mizukami H, Saito T, Uchida C, Igawa A, Kudo K, Itabashi C, Osonoi S, Danyang G, Sasaki T, Yagihashi S, Hakamada K.

Sci Rep. 10 ( 1 ) 1156 2020年01月

Corrigendum: Normal High HbA1c a Risk Factor for Abnormal Pain Threshold in the Japanese Population.

Itabashi C, Mizukami H, Osonoi S, Takahashi K, Kudo K, Wada K, Inaba W, Danyang G, Uchida C, Umetsu S, Igawa A, Ogasawara S, Ryuzaki M, Komeda K, Ishibashi Y, Yagihashi S, Nakaji S

Frontiers in endocrinology 11 130 2020年

Role of glucosamine in development of diabetic neuropathy independent of the aldose reductase pathway.

Mizukami H, Osonoi S, Takaku S, Yamagishi SI, Ogasawara S, Sango K, Chung S, Yagihashi S

Brain communications 2 ( 2 ) fcaa168 2020年

Role of Dysregulated Ion Channels in Sensory Neurons in Chronic Kidney Disease-Associated Pruritus.

Momose A, Yabe M, Chiba S, Kumakawa K, Shiraiwa Y, Mizukami H

Medicines (Basel, Switzerland) 6 ( 4 ) 2019年11月

Normal High HbA1c a Risk Factor for Abnormal Pain Threshold in the Japanese Population.

Itabashi C, Mizukami H, Osonoi S, Takahashi K, Kudo K, Wada K, Inaba W,　Danyang G, Uchida C, Umetsu S, Igawa A, Ogasawara S, Ryuzaki M, Komeda K,　Ishibashi Y, Yagihashi S, Nakaji S.

Front Endocrinol (Lausanne). 10 651 2019年10月

Dysregulated Ion Channels in Sensory Neurons in Chronic Kidney Disease-Associated　Pruritus.

Momose A, Yabe M, Chiba S, Kumakawa K, Shiraiwa Y, Mizukami H.

Medicines (Basel) 2019年09月

Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide.

Hara A, Nakagawa Y, Nakao K, Tamaki M, Ikemoto T, Shimada M, Matsuhisa M, Mizukami H, Maruyama N, Watada H, Fujitani Y.

Endocr J. 2019年05月

MYH7 mutation identified by next-generation sequencing in three infant siblings with bi-ventricular noncompaction presenting with restrictive hemodynamics: A report of three siblings with a severe phenotype and poor prognosis.

Miura F, Shimada J, Kitagawa Y, Otani K, Sato T, Toki T, Takahashi T, Yonesaka S, Mizukami H, Ito E

Journal of cardiology cases 19 ( 4 ) 140 - 143 2019年04月

Miura F, Shimada J, Kitagawa Y, Otani K, Sato T, Toki T, Takahashi T, Yonesaka S, Mizukami H, Ito E.

J Cardiol Cases. 2019年02月

Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide

Hara Akemi, Watada Hirotaka, Fujitani Yoshio, Nakagawa Yuko, Nakao Keiko, Tamaki Motoyuki, Ikemoto Tetsuya, Shimada Mitsuo, Matsuhisa Munehide, Mizukami Hiroki, Maruyama Nobuhiro

Endocrine Journal 66 ( 5 ) 459 - 468 2019年

Normal High HbA1c a Risk Factor for Abnormal Pain Threshold in the Japanese Population.

Itabashi C, Mizukami H, Osonoi S, Takahashi K, Kudo K, Wada K, Inaba W, Danyang G, Uchida C, Umetsu S, Igawa A, Ogasawara S, Ryuzaki M, Komeda K, Ishibashi Y, Yagihashi S, Nakaji S

Frontiers in endocrinology 10 651 2019年

Retinoic Acid-Inducible Gene-i and CXCL10 are Involved in Biliary Atresia

Kimura Toshiro, Imaizumi Tadaatsu, Yoshida Tatsuya, Shimada Taku, Hayakari Ryo, Kawaguchi Shogo, Yoshida Hidemi, Kobayashi Tamotsu, Hirabayashi Takeshi, Mizukami Hiroki, Kijima Hiroshi, Hakamada Kenichi

弘前医学 69 ( 1 ) 86 - 94 2019年

alveolar rhabdomyosarcoma in skin of abdominal wall of elderly patient: a case report

Makoto Abe, Chieko Itabashi, Kazuhiro Kudo, Hiroki Mizukami

Human Pathology: Case Reports 13 49 - 52 2018年09月

A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism

Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, Watabe K, Ogasawara

J Neurochem 144 ( 6 ) 710 - 722 2018年06月

A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism.

Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, Watabe K, Ogasawara S, Mizukami H, Yagihashi S, Chung SK, Sango K

Journal of neurochemistry 144 ( 6 ) 710 - 722 2018年03月

4．病理学的な変化～角膜共焦点顕微鏡と皮膚生検を中心に～

水上浩哉

糖尿病 61 ( 11 ) 750 - 753 2018年

Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation.

Saito T, Mizukami H, Umetsu S, Uchida C, Inaba W, Abe M, Takahashi K, Kudo K, Itabashi C, Yagihashi S, Hakamada K

Scientific reports 7 ( 1 ) 18056 2017年12月

High Osteogenic Potential of Adipose- and Muscle-derived Mesenchymal Stem Cells in Spinal-Ossification Model Mice.

Liu X, Kumagai G, Wada K, Tanaka T, Asari T, Oishi K, Fujita T, Mizukami H,他

Spine 2017年12月

A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism.

Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, Watabe K, Ogasawara S, Mizukami H,他

Journal of Neurochemistry 2017年12月

Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation.

Saito T, Mizukami H, 他

Scientific reports 7 18056 2017年12月

Pancreas Atrophy and Islet Amyloid Deposition in Patients With Elderly-Onset Type 2 Diabetes.

Xin A, Mizukami H, Inaba W, Yoshida T, Takeuchi YK, Yagihashi S

The Journal of clinical endocrinology and metabolism 102 ( 9 ) 3162 - 3171 2017年09月

Pancreas Atrophy and Islet Amyloid Deposition in Patients With Elderly-Onset Type 2 Diabetes.

Xin A, Mizukami H, 他

Journal of Clinical Endocrinology and Metabolism 2017年09月

Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa.

Funamizu Y, Nishijima H, Ueno T, Ueno S, Mizukami H, 他

Neuroscience Research 2017年08月

Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa.

Funamizu Y, Nishijima H, Ueno T, Ueno S, Mizukami H, Yagihashi S, Tomiyama M

Neuroscience research 121 49 - 53 2017年08月

CCL5 is induced by TLR 3 signaling in HuCCT1 human biliary epithelial cells: possible involvement in the pathogenesis of biliary atresia.

Shimada T, Imaizumi T, Shirai K, Tatsuta T, Kimura T, Hayakari R, Yoshida H, Matsumiya T, Kijima H, Mizukami H,他

Biomedical Research 2017年05月

CCL5 is induced by TLR 3 signaling in HuCCT1 human biliary epithelial cells: possible involvement in the pathogenesis of biliary atresia

SHIMADA Taku, MIZUKAMI Hiroki, HAKAMADA Kenichi, IMAIZUMI Tadaatsu, SHIRAI Kyogo, TATSUTA Tetsuya, KIMURA Toshiro, HAYAKARI Ryo, YOSHIDA Hidemi, MATSUMIYA Tomoh, KIJIMA Hiroshi

Biomedical Research 38 ( 5 ) 269 - 276 2017年

Impaired Axonal Regeneration in Diabetes. Perspective on the Underlying Mechanism from In Vivo and In Vitro Experimental Studies.

Sango K, Mizukami H, Horie H, Yagihashi S

Frontiers in endocrinology 8 12 2017年

心囊液中に腫瘍細胞が認められた ACTH 産生胸腺原発非定型的カルチノイドの 1 例

刀稱亀代志, 小島啓子, 熊谷直哉, 水上浩哉, 黒瀬顕

日本臨床細胞学会雑誌 56 ( 5 ) 255 - 256 2017年

Modified Parasympathetic Nervous System in Goto-Kakizaki Diabetic Rats

Han Chong, Inaba Wataru, Yonekura Manabu, Ogata Yoshiki, Ohba Takayoshi, Kushikata Tetsuya, Niwa Hidetoshi, Yanagisawa Teruyuki, Tomita Hirofumi, Itagaki Shirou, Hirota Kazuyoshi, Akai Hiroaki, Mizukami Hiroki, Murakami Manabu

弘前医学 68 ( 1 ) 33 - 43 2017年

Is Stem Cell Transplantation Ready for Prime Time in Diabetic Polyneuropathy?

Mizukami H, Yagihashi S

Current diabetes reports 16 ( 9 ) 86 2016年09月

Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation.

Taguchi Y, Allende ML, Mizukami H, Cook EK, Gavrilova O, Tuymetova G, Clarke BA, Chen W, Olivera A, Proia RL.

J Biol Chem. 291 ( 23 ) 12029 - 12038 2016年06月

Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation.

Taguchi Y, Allende ML, Mizukami H, Cook EK, Gavrilova O, Tuymetova G, Clarke BA, Chen W, Olivera A, Proia RL

The Journal of biological chemistry 291 ( 23 ) 12029 - 38 2016年06月

[Pathophysiology of diabetic polyneuropathy].

Mizukami H

Nihon rinsho. Japanese journal of clinical medicine 74 Suppl 2 229 - 33 2016年04月

Dynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implications.

Yagihashi S, Inaba W, Mizukami H

Journal of diabetes investigation 7 ( 2 ) 155 - 65 2016年03月

The dipeptidyl peptidase IV inhibitor vildagliptin suppresses development of neuropathy in diabetic rodents: effects on peripheral sensory nerve function, structure and molecular changes.

Tsuboi K, Mizukami H, Inaba W, Baba M, Yagihashi S

Journal of neurochemistry 136 ( 4 ) 859 - 870 2016年02月

〈一般演題抄録〉下気道におけるレチノイン酸誘導遺伝子-Ⅰ様受容体を介した抗ウイルス自然免疫応答

千葉友揮, 伊藤悦朗, 松宮朋穂, 佐藤次生, 早狩亮, 邢飛, 吉田秀見, 丹治邦和, 水上浩哉, 今泉忠淳

弘前医学 67 ( 1 ) 2016年

The dipeptidyl peptidase IV inhibitor vildagliptin suppresses development of neuropathy in diabetic rodents: Effects on peripheral sensory nerve function, structure and molecular changes.

Tsuboi K, Mizukami H, Inaba W, Baba M, Yagihashi S.

J Neurochem. 2015年11月

Retinoic acid-inducible gene-I-like receptor (RLR)-mediated antiviral innate immune responses in the lower respiratory tract: Roles of TRAF3 and TRAF5.

Chiba Y et al.

Biochem Biophys Res Commun. 467 ( 2 ) 191 - 196 2015年11月

Retinoic acid-inducible gene-I-like receptor (RLR)-mediated antiviral innate immune responses in the lower respiratory tract: Roles of TRAF3 and TRAF5.

Chiba Y, Matsumiya T, Satoh T, Hayakari R, Furudate K, Xing F, Yoshida H, Tanji K, Mizukami H, Imaizumi T, Ito E

Biochemical and biophysical research communications 467 ( 2 ) 191 - 6 2015年11月

Case of pachydermoperiostosis with solute carrier organic anion transporter family, member 2A1 (SLCO2A1) mutations.

Minakawa S, et al.

J Dermatol. 42 ( 9 ) 908 - 910 2015年09月

Quo vadis: Where have the β-cells gone?

Yagihashi S, Mizukami H, Inaba W

Journal of diabetes investigation 6 ( 4 ) 393 - 5 2015年07月

Case of oculocutaneous albinism complicated with squamous cell carcinoma, Bowen's disease and actinic keratosis.

Minakawa S, Kaneko T, Matsuzaki Y, Akasaka E, Mizukami H, Abe Y, Hozumi Y, Suzuki T, Mitsuhashi Y, Sawamura D

The Journal of dermatology 41 ( 9 ) 863 - 4 2014年09月

Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients.

Kamata K, Mizukami H, Inaba W, Tsuboi K, Tateishi Y, Yoshida T, Yagihashi S

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 21 ( 3 ) 191 - 201 2014年09月

Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline of β-cell mass in Japanese type 2 diabetic patients.

Mizukami H, Takahashi K, Inaba W, Tsuboi K, Osonoi S, Yoshida T, Yagihashi S

Diabetes care 37 ( 7 ) 1966 - 74 2014年07月

B-cell malignant lymphoma presenting as otitis media and mastoiditis associated with sinus thrombosis.

Saito A, Jia W, Sasaki T, Mizukami H, Sasaki A, Shinkawa H, Nishijima M

Case reports in neurology 6 ( 2 ) 161 - 5 2014年05月

Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese.

Mizukami H, Takahashi K, Inaba W, Osonoi S, Kamata K, Tsuboi K, Yagihashi S

Journal of diabetes investigation 5 ( 1 ) 38 - 47 2014年02月

Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament.

Harada Y, Furukawa K, Asari T, Chin S, Ono A, Tanaka T, Mizukami H, Murakami M, Yagihashi S, Motomura S, Ishibashi Y

Biochemical and biophysical research communications 443 ( 3 ) 1014 - 20 2014年01月

Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients.

Kamata K他

Amyloid 21 191 - 201 2014年

Involvement of Oxidative Stress-Induced DNA Damage, Endoplasmic Reticulum Stress, and Autophagy Deficits in the Decline of β-Cell Mass in Japanese Type 2 Diabetic Patients.

Mizukami H他

Diabetes Care 37 1966 - 1974 2014年

Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament.

Harada Y他

Biochem Biophys Res Commun 443 1014 - 1020 2014年

Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese, J Diabetes Invest.

Mizukami H他

J Diabetes Investig 5 38 - 47 2014年

6. 成因について

水上浩哉, 八木橋操六

糖尿病 57 ( 8 ) 609 - 612 2014年

２型糖尿病における膵β細胞容積低下機序の解明

水上浩哉

弘前医学 65 ( 1 ) 104 - 106 2014年

Exploring a new therapy for diabetic polyneuropathy - the application of stem cell transplantation.

Mizukami H, Yagihashi S

Frontiers in endocrinology 5 45 2014年

Exendin-4 improves beta cell function in autophagy-deficient beta cells.

Abe H他

Endocrinology 154 ( 12 ) 4512 - 4524 2013年12月

Exendin-4 improves β-cell function in autophagy-deficient β-cells.

Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku Y, Ogihara T, Uchiyama Y, Yagihashi S, Fujitani Y, Watada H

Endocrinology 154 ( 12 ) 4512 - 24 2013年12月

Impaired nerve fiber regeneration in axotomized peripheral nerves in streptozotocin-diabetic rats.

Nishida N, Yamagishi S, Mizukami H, Yagihashi S

Journal of diabetes investigation 4 ( 6 ) 533 - 9 2013年11月

Impaired nerve fiber regeneration in axotomized peripheral nerves in streptozotocin-diabetic rats.

Nishida N他

Journalof Diabetes Investigation 4 ( 6 ) 533 - 539 2013年09月

Immunohistochemical localization of mesenchymal stem cells in ossified human spinal ligaments.

Chin S他

Biochem Biophys Res Commun 436 ( 4 ) 698 - 704 2013年07月

Immunohistochemical localization of mesenchymal stem cells in ossified human spinal ligaments.

Chin S, Furukawa K, Ono A, Asari T, Harada Y, Wada K, Tanaka T, Inaba W, Mizukami H, Motomura S, Yagihashi S, Ishibashi Y

Biochemical and biophysical research communications 436 ( 4 ) 698 - 704 2013年07月

The effects of dipeptidyl-peptidase-IV inhibitor, vildagliptin, on the exocrine pancreas in spontaneously diabetic Goto-Kakizaki rats.

Mizukami H他

Pancreas. 42 786 - 794 2013年07月

The effects of dipeptidyl-peptidase-IV inhibitor, vildagliptin, on the exocrine pancreas in spontaneously diabetic Goto-Kakizaki rats.

Mizukami H, Inaba W, Takahashi K, Kamata K, Tsuboi K, Yagihashi S

Pancreas 42 ( 5 ) 786 - 94 2013年07月

糖尿病におけるα細胞の相対的・絶対的な量の変化

水上浩哉

糖尿病 55 ( 11 ) 845 - 848 2012年11月

Loss of ARID1A expression is an early molecular event in tumor progression from ovarian endometriotic cyst to clear cell and endometrioid carcinoma.

Ayhan A, Mao TL, Seckin T, Wu CH, Guan B, Ogawa H, Futagami M, Mizukami H, Yokoyama Y, Kurman RJ, Shih IeM

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 22 ( 8 ) 1310 - 5 2012年10月

Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on　islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats.

Inaba W

Eur J　Pharmacol. 691 297 - 36 2012年09月

Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats.

Inaba W, Mizukami H, Kamata K, Takahashi K, Tsuboi K, Yagihashi S

European journal of pharmacology 691 ( 1-3 ) 297 - 306 2012年09月

The femoral insertion of the anterior cruciate ligament:　discrepancy between macroscopic and histological observations

Sasaki N

Arthroscopy 28 ( 8 ) 1135 - 1146 2012年08月

The femoral insertion of the anterior cruciate ligament: discrepancy between macroscopic and histological observations.

Sasaki N, Ishibashi Y, Tsuda E, Yamamoto Y, Maeda S, Mizukami H, Toh S, Yagihashi S, Tonosaki Y

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 28 ( 8 ) 1135 - 46 2012年08月

Post injury changes in the properties of　mesenchymal stem cells derived from human anterior cruciate ligaments.

Nohmi S

Int　Orthop. 36 ( 7 ) 1515 - 1522 2012年07月

Augmented reduction of islet β-cell mass in Goto-Kakizaki rats fed high-fat diet and its suppression by pitavastatin treatment.

Mizukami H, Inaba W, Takahashi K, Inoue K, Sawanobori K, Yagihashi S

Journal of diabetes investigation 3 ( 3 ) 235 - 44 2012年06月

Mesenchymal stem cell isolation and　characterization from human spinal ligaments.

Asari T

Biochem Biophys Res Commun. 417 ( 4 ) 1193 - 1199 2012年01月

Mesenchymal stem cell isolation and characterization from human spinal ligaments.

Asari T, Furukawa K, Tanaka S, Kudo H, Mizukami H, Ono A, Numasawa T, Kumagai G, Motomura S, Yagihashi S, Toh S

Biochemical and biophysical research communications 417 ( 4 ) 1193 - 9 2012年01月

Efficacy of adipose tissue-derived mesenchymal stem cells for fulminant hepatitis　in mice induced by concanavalin A.

Kubo N

J Gastroenterol Hepatol. 27 ( 1 ) 165 - 172 2012年01月

Amelioration of acute kidney injury in lipopolysaccharide-induced systemic　inflammatory response syndrome by an aldose reductase inhibitor, fidarestat.

Takahashi K

PLoS　One. 7 ( 1 ) e30134 2012年01月

Efficacy of adipose tissue-derived mesenchymal stem cells for fulminant hepatitis in mice induced by concanavalin A.

Kubo N, Narumi S, Kijima H, Mizukami H, Yagihashi S, Hakamada K, Nakane A

Journal of gastroenterology and hepatology 27 ( 1 ) 165 - 72 2012年01月

Amelioration of acute kidney injury in lipopolysaccharide-induced systemic inflammatory response syndrome by an aldose reductase inhibitor, fidarestat.

Takahashi K, Mizukami H, Kamata K, Inaba W, Kato N, Hibi C, Yagihashi S

PloS one 7 ( 1 ) e30134 2012年

3.糖尿病におけるα細胞の相対的・絶対的な量の変化

水上浩哉

糖尿病 55 ( 11 ) 845 - 848 2012年

自家脂肪織由来間葉系幹細胞の慢性糖尿病ラット胃腸障害に対する移植効果

水上浩哉, 高橋一徳, 杉本一博, 馬場正之, 八木橋操六

末梢神経 = Peripheral nerve 22 ( 2 ) 204 - 205 2011年12月

Polyol pathway and diabetic nephropathy revisited: Early tubular cell changes and glomerulopathy in diabetic mice overexpressing human aldose reductase.

Hashimoto Y, Yamagishi S, Mizukami H, Yabe-Nishimura C, Lim SW, Kwon HM, Yagihashi S

Journal of diabetes investigation 2 ( 2 ) 111 - 22 2011年04月

Methylcobalamin effects on diabetic neuropathy and nerve protein kinase C in rats.

Mizukami H

Eur J Clin Invest. 41 442 - 450 2011年04月

Mechanism of diabetic neuropathy: Where are we now and where to go?

Yagihashi S, Mizukami H, Sugimoto K

Journal of diabetes investigation 2 ( 1 ) 18 - 32 2011年01月

脂肪織由来間葉系幹細胞自家移植による糖尿病ラット進行期神経障害への治療効果

水上浩哉, 山岸普一郎, 小笠原早織, 高橋一徳, 稲葉渉, 杉本一博, 馬場正之, 八木橋操六

末梢神経 = Peripheral nerve 21 ( 2 ) 338 - 339 2010年12月

[Cytokine role in diabetic neuropathy].

Mizukami H, Yagihashi S

Nihon rinsho. Japanese journal of clinical medicine 68 Suppl 9 563 - 7 2010年11月

脾臓原発の炎症性偽腫瘍型濾胞樹状細胞肉腫例

高橋一徳, 矢嶋信久, 中山義人, 水上浩哉, 和田龍一, 石黒彩子, 賀佐富士彦, 八木橋操六

診断病理 : Japanese journal of diagnostic pathology 27 ( 3 ) 229 - 232 2010年07月

Serotonin regulates pancreatic beta cell mass during pregnancy.

Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, Fujitani Y, Kawamori R, Miyatsuka T, Kosaka Y, Yang K, Honig G, van der Hart M, Kishimoto N, Wang J, Yagihashi S, Tecott LH, Watada H, German MS

Nature medicine 16 ( 7 ) 804 - 8 2010年07月

The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice.

Yagihashi S, Mizukami H, Ogasawara S, Yamagishi S, Nukada H, Kato N, Hibi C, Chung S, Chung S

The Journal of pathology 220 ( 5 ) 530 - 41 2010年04月

脂肪織由来間葉系幹細胞の単離と糖尿病ラット進行期神経障害への効果

水上浩哉, 山岸普一朗, 小笠原早織, 稲葉渉, 八木橋操六

末梢神経 = Peripheral nerve 20 ( 2 ) 207 - 208 2009年12月

Small cell carcinoma with skeletal muscle differentiation of urinary bladder

YAJIMA Nobuhisa, MIZUKAMI Hiroki, WADA Ryuichi, SAITO Fumitada, YAGIHASHI Soroku

Pathology international 59 ( 10 ) 748 - 751 2009年10月

Small cell carcinoma with skeletal muscle differentiation of urinary bladder.

Yajima N, Mizukami H, Wada R, Saito F, Yagihashi S

Pathology international 59 ( 10 ) 748 - 51 2009年10月

Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma.

Shirasaki T, et. al.

BMC Cancer 8 ( 11 ) 348 - 359 2008年11月

Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma.

Shirasaki T, Maruya S, Mizukami H, Kakehata S, Kurotaki H, Yagihashi S, Shinkawa H

BMC cancer 8 348 2008年11月

Suppression of post-prandial hyperglycaemia by pioglitazone improved islet fibrosis and macrophage migration in the Goto-Kakizaki rat.

Mizukami H, et al.

Diabetes, obesity & metabolism 10 ( 9 ) 791 - 794 2008年09月

自然発症糖尿病GKラットの糖代謝・膵島病変に対するピタバスタチンの作用

水上浩哉　他

PROGRESS IN MEDICINE 28 ( 4 ) 999 - 1006 2008年04月

Augmented beta cell loss and mitochondrial abnormalities in sucrose-fed GK rats.

Mizukami H, et al.

Virchows Archiv 452 ( 4 ) 383 - 92 2008年04月

Augmented beta cell loss and mitochondrial abnormalities in sucrose-fed GK rats.

Mizukami H, Wada R, Koyama M, Takeo T, Suga S, Wakui M, Yagihashi S

Virchows Archiv : an international journal of pathology 452 ( 4 ) 383 - 92 2008年04月

Correction of protein kinase C activity and macrophage migration in peripheral nerve by pioglitazone, peroxisome proliferator activated-gamma-ligand, in insulin-deficient diabetic rats.

Yamagishi S, Ogasawara S, Mizukami H, Yajima N, Wada R, Sugawara A, Yagihashi S

Journal of neurochemistry 104 ( 2 ) 491 - 9 2008年01月

Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells.

Takeda I, Maruya S, Shirasaki T, Mizukami H, Takahata T, Myers JN, Kakehata S, Yagihashi S, Shinkawa H

Cancer science 98 ( 6 ) 890 - 9 2007年06月

Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells.(共著)

Takeda I, Maruya S, Shirasaki T, Mizukami H, Takahata T, Myers JN, Kakehata S, Yagihashi S, Shinkawa H.

Cancer Science 98 ( 6 ) 890 - 899 2007年04月

Implication of proinfl ammatory reactions in pathogenesis of diabetic microvascular complications

Yagihashi Soroku, Yamagishi Shin-ichiro, Mizukami Hiroki, Wada Ryuichi

弘前医学 59 ( 0 ) S101 - 108 2007年

Novel mechanism of chronic exposure of oleic acid-induced insulin release impairment in rat pancreatic beta-cells.

Kudo T, et al.

The Journal of pharmacology and experimental therapeutics 318 ( 3 ) 1203 - 1210 2006年09月

Novel mechanism of chronic exposure of oleic acid-induced insulin release impairment in rat pancreatic beta-cells.

Kudo T, Wu J, Ogawa Y, Suga S, Hasegawa N, Suda T, Mizukami H, Yagihashi S, Wakui M

The Journal of pharmacology and experimental therapeutics 318 ( 3 ) 1203 - 10 2006年09月

Ganglioside GM3 promotes cell migration by regulating MAPK and c-Fos/AP-1.

Hashiramoto A, et al.

Oncogene 25 ( 28 ) 3948 - 3955 2006年06月

Pancreatic malignant fibrous histiocytoma, inflammatory myofibroblastic tumor, and inflammatory pseudotumor related to autoimmune pancreatitis

Mizukami H, et al.

Virchows Archiv : an international journal of pathology 448 ( 5 ) 552 - 560 2006年05月

Pancreatic malignant fibrous histiocytoma, inflammatory myofibroblastic tumor, and inflammatory pseudotumor related to autoimmune pancreatitis: characterization and differential diagnosis.

Mizukami H, Yajima N, Wada R, Matsumoto K, Kojima M, Klöppel G, Yagihashi S

Virchows Archiv : an international journal of pathology 448 ( 5 ) 552 - 60 2006年05月

Aortic Valve Perforation Due to Latent Infective Endocarditis

MUNAKATA Mamoru, ITAYA Hiroyuki, MIZUKAMI Hiroki, ONO Yuichi

日本胸部外科学会雑誌 = The Japanese journal of thoracic and cardiovascular surgery 54 ( 2 ) 67 - 69 2006年02月

Aortic valve perforation due to latent infective endocarditis.

Munakata M, et al.

The Japanese journal of thoracic and cardiovascular surgery 54 ( 2 ) 67 - 69 2006年02月

Spindle cell metaplasia arising in thyroid adenoma: characterization of its pathology and differential diagnosis.

Shikama Y, et al.

Journal of Endocrinological Investigation 29 ( 2 ) 168 - 171 2006年02月

Aortic valve perforation due to latent infective endocarditis.

Munakata M, Itaya H, Mizukami H, Ono Y

The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 54 ( 2 ) 67 - 9 2006年02月

Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and　neuroendocrine cell markers in epithelial neoplasm of appendix.

Yajima N, et. al.

Human pathology 36 ( 11 ) 1217 - 1225 2005年11月

Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix.

Yajima N, Wada R, Yamagishi S, Mizukami H, Itabashi C, Yagihashi S

Human pathology 36 ( 11 ) 1217 - 25 2005年11月

Interruption of ganglioside synthesis produces central nervous system　degeneration and altered axon-glial interactions.

Yamashita T, et. al.

Proceedings of the National Academy of Sciences of the United States of America 102 ( 8 ) 2725 - 2730 2005年02月

Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions.

Yamashita T, Wu YP, Sandhoff R, Werth N, Mizukami H, Ellis JM, Dupree JL, Geyer R, Sandhoff K, Proia RL

Proceedings of the National Academy of Sciences of the United States of America 102 ( 8 ) 2725 - 30 2005年02月

Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the　brain of Niemann-Pick type C disease

Wu YP, et. al.

Molecular Genetics and Metabolism 84 ( 1 ) 9 - 17 2005年01月

Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease.

Wu YP, Mizukami H, Matsuda J, Saito Y, Proia RL, Suzuki K

Molecular genetics and metabolism 84 ( 1 ) 9 - 17 2005年01月

Global gene expression in a type 2 Gaucher disease brain

Myerowitz R, et. al.

MOLECULAR GENETICS AND METABOLISM 83 ( 4 ) 288 - 296 2004年12月

Global gene expression in a type 2 Gaucher disease brain.

Myerowitz R, Mizukami H, Richardson KL, Finn LS, Tifft CJ, Proia RL

Molecular genetics and metabolism 83 ( 4 ) 288 - 96 2004年12月

糖尿病性神経障害の新しい病因論と治療への展望

八木橋操六, 和田龍一, 山岸晋一朗, 水上浩哉

末梢神経 = Peripheral nerve 15 ( 1 ) 1 - 16 2004年06月

Enhanced insulin sensitivity in mice lacking ganglioside GM3

Yamashita T, et. al.

Proceedings of the National Academy of Sciences of the United States of America 100 ( 6 ) 3445 - 3449 2003年03月

Enhanced insulin sensitivity in mice lacking ganglioside GM3.

Yamashita T, Hashiramoto A, Haluzik M, Mizukami H, Beck S, Norton A, Kono M, Tsuji S, Daniotti JL, Werth N, Sandhoff R, Sandhoff K, Proia RL

Proceedings of the National Academy of Sciences of the United States of America 100 ( 6 ) 3445 - 9 2003年03月

Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles.

Miura K, Bowman ED, Simon R, Peng AC, Robles AI, Jones RT, Katagiri T, He P, Mizukami H, Charboneau L, Kikuchi T, Liotta LA, Nakamura Y, Harris CC

Cancer research 62 ( 11 ) 3244 - 50 2002年06月

Molecular pathophysiology in Tay-Sachs and Sandhoff diseases as revealed by gene expression profiling.

Myerowitz R, Lawson D, Mizukami H, Mi Y, Tifft CJ, Proia RL

Human molecular genetics 11 ( 11 ) 1343 - 50 2002年05月

Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage.

Mizukami H, Mi Y, Wada R, Kono M, Yamashita T, Liu Y, Werth N, Sandhoff R, Sandhoff K, Proia RL

The Journal of clinical investigation 109 ( 9 ) 1215 - 21 2002年05月

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