Papers - TOKI TSUTOMU
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Molecular Remission Confirmed by Monitoring a PTPN11 Mutation in Myeloid Leukemia of Down Syndrome Treated With Reduced-Intensity Stem Cell Transplantation: A Case Report.
Yoshida T, Muramatsu H, Ishikawa S, Oikawa K, Asakura Y, Miura S, Yashima-Abo A, Nishizuka SS, Wakamatsu M, Terui K, Toki T, Ito E, Endo M, Akasaka M
Pediatric blood & cancer 73 ( 2 ) e70077 2026.2
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Functional impact of a deep intronic variant in the RPS19 gene detected in a case of Diamond-Blackfan anemia syndrome.
Kanezaki R, Toki T, Okuse R, Kobayashi A, Sato M, Kimura S, Kudo K, Sato T, Tanaka T, Yoshida K, Kawai Y, Tokunaga K, Takita J, Ogawa S, Terui K, Ito E
Haematologica 2026.1
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Detection of clonal selection by multicolor flow cytometry in TAM with multiple GATA1 mutations.
Kohso A, Iwamoto S, Niwa K, Nannya Y, Toki T, Hanaki R, Toyoda H, Deguchi T, Ogawa S, Terui K, Ito E, Hirayama M
International journal of hematology 2025.11
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‹一般演題抄録›結節性硬化症11例における原因遺伝子変異の検討
山本 洋平, 山本 達也, 工藤 耕, 土岐 力, 金崎 里香, 伊東 竜也, 品川 友江, 浅利 有紗, 梅津 英典, 伊藤 悦朗, 照井 君典
弘前医学 75 ( 1 ) 81 2024.10
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ダウン症候群に伴う骨髄性白血病における微小残存病変検出法の改善
奥瀬 諒, 土岐 力, 吉田 健一, 多賀 崇, 金崎 里香, 工藤 耕, 岩本 彰太郎, 平松 英文, 橋井 佳子, 長谷川 大輔, 宮村 能子, 濱 麻人, 中島 健太郎, 田中 司朗, 齋藤 明子, 堀部 敬三, 足立 壯一, 富澤 大輔, 盛武 浩, 伊藤 悦朗, 照井 君典
日本血液学会学術集会 86回 P3 - 3 2024.10
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難治性ランゲルハンス細胞組織球症に対するvemurafenib治療症例における測定可能残存病変
工藤 耕, 金崎 里香, 小野 林太郎, 坂本 謙一, 辻本 信一, 市川 貴之, 長谷川 大一郎, 渡邉 健一郎, 田中 龍彦, 土岐 力, 伊藤 悦朗, 加藤 元博, 塩田 曜子
日本血液学会学術集会 86回 O1 - 5 2024.10
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結節性硬化症11例における原因遺伝子変異の検討
山本 洋平, 山本 達也, 工藤 耕, 土岐 力, 金崎 里香, 伊東 竜也, 品川 友江, 浅利 有紗, 梅津 英典, 伊藤 悦朗, 照井 君典
弘前医学 75 ( 1 ) 81 - 81 2024.10
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ダウン症候群の骨髄性白血病における体細胞変異の全体像とその臨床的影響
佐藤 知彦, 吉田 健一, 土岐 力, 金崎 理香, 照井 君典, 佐伯 龍之介, 小島 正美, 越智 陽太郎, 上地 珠代, 剣持 直哉, 田中 司朗, 松林 潤, 工藤 耕, 湯沢 健太郎, 高橋 佑果, 村松 秀城, 長谷川 大輔, 出口 隆生, 松尾 英将, 足立 壯一, 林 泰秀, 多賀 崇, 齋藤 明子, 堀部 敬三, 渡邉 健一郎, 富澤 大輔, 宮野 悟, 高橋 智, 小川 誠司, 伊藤 悦朗
日本血液学会学術集会 86回 O1 - 6 2024.10
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Mutational analysis by targeted sequencing in 11 cases of tuberous sclerosis
Yamamoto Yohei, Yamamoto Tatsuya, Kudo Ko, Toki Tsutomu, Kanezaki Rika, Ito Tatsuya, Shinagawa Tomoe, Asari Arisa, Umetsu Hidenori, Fujita Hiroshi, Ito Etsuro, Terui Kiminori
Hirosaki Medical Journal 74 ( 1-4 ) 17 - 27 2024.3
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Landscape of driver mutations and their clinical effects on Down syndrome-related myeloid neoplasms
Tomohiko Sato, Kenichi Yoshida, Tsutomu Toki, Rika Kanezaki, Kiminori Terui, Ryunosuke Saiki, Masami Ojima, Yotaro Ochi, Seiya Mizuno, Masaharu Yoshihara, Tamayo Uechi, Naoya Kenmochi, Shiro Tanaka, Jun Matsubayashi, Kenta Kisai, Ko Kudo, Kentaro Yuzawa, Yuka Takahashi, Tatsuhiko Tanaka, Yohei Yamamoto, Akie Kobayashi, Takuya Kamio, Shinya Sasaki, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Muramatsu, Asahito Hama, Daisuke Hasegawa, Atsushi Sato, Katsuyoshi Koh, Shuhei Karakawa, Masao Kobayashi, Junichi Hara, Yuichi Taneyama, Chihaya Imai, Daiichiro Hasegawa, Naoto Fujita, Masahiro Yoshitomi, Shotaro Iwamoto, Genki Yamato, Satoshi Saida, Nobutaka Kiyokawa, Takao Deguchi, Masafumi Ito, Hidemasa Matsuo, Souichi Adachi, Yasuhide Hayashi, Takashi Taga, Akiko Moriya Saito, Keizo Horibe, Kenichiro Watanabe, Daisuke Tomizawa, Satoru Miyano, Satoru Takahashi, Seishi Ogawa, Etsuro Ito
Blood Journal 143 ( 25 ) 2627 - 2643 2024.3
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Transient erythroblastopenia due to a <i>GATA1</i> variant in an infant female
Motoi Yamashita, Takahiro Tomoda, Ami Mizuo, Takeshi Isoda, Makiko Egawa, Masayuki Yoshida, Tsutomu Toki, Ko Kudo, Kiminori Terui, Etsuro Ito, Tomohiro Morio, Masatoshi Takagi
Pediatric Blood & Cancer 71 ( 3 ) e30834 2024.3
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Antileukemic effect of azacitidine, a DNA methyltransferase inhibitor, on cell lines of myeloid leukemia associated with Down syndrome.
Tatsuhiko Tanaka, Ko Kudo, Rika Kanezaki, Kentaro Yuzawa, Tsutomu Toki, Ryo Okuse, Akie Kobayashi, Tomohiko Sato, Takuya Kamio, Kiminori Terui, Etsuro Ito
Experimental hematology 132 104179 - 104179 2024.2
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Early-onset Marfan syndrome with a novel missense mutation: A case report.
Kana Soma, Yosuke Kitagawa, Tsutomu Toki, Fumitake Miura, Jun Shimada, Tomohiko Sato, Ko Kudo, Katsuki Otani, Toru Takahashi, Kiminori Terui
Journal of cardiology cases 27 ( 6 ) 283 - 286 2023.6
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グルココルチコイド受容体point mutationによるグルココルチコイド抵抗症二家系の解析
高安 忍, 浅利 ゆう子, 崎原 哲, 須田 俊宏, 臼谷 真理, 中田 有紀, 綿貫 裕, 土岐 力, 金崎 里香, 蔭山 和則, 大門 眞
日本内分泌学会雑誌 99 ( 1 ) 301 - 301 2023.5
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グルココルチコイド受容体point mutationによるグルココルチコイド抵抗症二家系の解析
高安 忍, 浅利 ゆう子, 崎原 哲, 須田 俊宏, 臼谷 真理, 中田 有紀, 綿貫 裕, 土岐 力, 金崎 里香, 蔭山 和則, 大門 眞
日本内分泌学会雑誌 99 ( 1 ) 301 - 301 2023.5
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次世代シークエンサーを用いた結節性硬化症の遺伝学的検討
山本 洋平, 山本 達也, 土岐 力, 奥瀬 諒, 伊東 竜也, 梅津 英典, 工藤 耕, 伊藤 悦朗, 照井 君典, 品川 友江, 浅利 有紗, 藤田 浩史
日本小児科学会雑誌 127 ( 4 ) 664 - 664 2023.4
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Dyserythropoietic anaemia with an intronic GATA1 splicing mutation in patients suspected to have Diamond-Blackfan anaemia
Akie Kobayashi, Ryusei Ohtaka, Tsutomu Toki, Junichi Hara, Hideki Muramatsu, Rika Kanezaki, Yuka Takahashi, Tomohiko Sato, Takuya Kamio, Ko Kudo, Shinya Sasaki, Taro Yoshida, Taiju Utsugisawa, Hitoshi Kanno, Kenichi Yoshida, Yasuhito Nannya, Yoshiyuki Takahashi, Seiji Kojima, Satoru Miyano, Seishi Ogawa, Kiminori Terui, Etsuro Ito
eJHaem 3 163 - 167 2022.12
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Mechanism of KIT gene regulation by GATA1 lacking the N-terminal domain in Down syndrome-related myeloid disorders.
Rika Kanezaki, Tsutomu Toki, Kiminori Terui, Tomohiko Sato, Akie Kobayashi, Ko Kudo, Takuya Kamio, Shinya Sasaki, Koji Kawaguchi, Kenichiro Watanabe, Etsuro Ito
Scientific reports 12 ( 1 ) 20587 - 20587 2022.11
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NTRK1遺伝子変異を認めた先天性無痛無汗症の1例
黒瀧 奎吾, 梅津 英典, 伊東 竜也, 八木 弘子, 山本 達也, 土岐 力, 照井 君典, 町田 佳織
日本小児科学会雑誌 126 ( 4 ) 734 - 735 2022.4
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BRAFV600E-positive cells as molecular markers of bone marrow disease in pediatric Langerhans cell histiocytosis.
Kudo K, Toki T, Kanezaki R, Tanaka T, Kamio T, Sato T, Sasaki S, Imamura M, Imai C, Ando K, Kakuda H, Doi T, Kawaguchi H, Irie M, Sasahara Y, Tamura A, Hasegawa D, Itakura Y, Watanabe K, Sakamoto K, Shioda Y, Kato M, Kudo K, Fukano R, Sato A, Yagasaki H, Kanegane H, Kato I, Umeda K, Adachi S, Kataoka T, Kurose A, Nakazawa A, Terui K, Ito E
Haematologica - ( 7 ) 1719 - 1725 2022.3
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Childhood acute myeloid leukemia with 5q deletion and HNRNPH1-MLLT10 fusion: the first case report.
Ko Kudo, Yasuo Kubota, Tsutomu Toki, Rika Kanezaki, Akie Kobayashi, Tomohiko Sato, Takuya Kamio, Shinya Sasaki, Norio Shiba, Daisuke Tomizawa, Souichi Adachi, Kenichi Yoshida, Seishi Ogawa, Masafumi Seki, Junko Takita, Etsuro Ito, Kiminori Terui
Blood advances 6 ( 10 ) 3162 - 3166 2022.2
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A Case of Congenital Leukemia With MYB-GATA1 Fusion Gene in a Female Patient.
Shuichi Ozono, Shoichiro Yano, Saori Oishi, Miho Mitsuo, Shinichiro Nakagawa, Tsutomu Toki, Kiminori Terui, Etsuro Ito
Journal of pediatric hematology/oncology 44 ( 1 ) e250 - e252 2022.1
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Erythromelalgia presenting as recurrent purpura and hypogammaglobulinemia: A case report
Karasawa Takao, Hashimoto Shun, Sato Riko, Fujita Masashi, Aizawa Tomomi, Tsugawa Koji, Toki Tsutomu, Kanezaki Rika, Sato Tomohiko, Kudo Ko, Terui Kiminori, Tanaka Hiroshi
Hirosaki Medical Journal 72 ( 1-4 ) 80 - 83 2022
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Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly
伊藤 由馬, 徳永 万喜洋, 原口 徳子, 粟津 暁紀, 落合 博, 土岐 力, 伊藤 悦朗, 中尾 光善, 斉藤 典子
Life Sci Alliance 5 ( 7 ) 2022
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Correction to: Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome (Leukemia, (2021), 35, 9, (2508-2516), 10.1038/s41375-021-01157-w)
Takashi Taga, Shiro Tanaka, Daisuke Hasegawa, Kiminori Terui, Tsutomu Toki, Shotaro Iwamoto, Hidefumi Hiramatsu, Takako Miyamura, Yoshiko Hashii, Hiroshi Moritake, Hideki Nakayama, Hiroyuki Takahashi, Akira Shimada, Tomohiko Taki, Etsuro Ito, Asahito Hama, Masafumi Ito, Katsuyoshi Koh, Daiichiro Hasegawa, Akiko M. Saito, Souichi Adachi, Daisuke Tomizawa
Leukemia 35 ( 12 ) 3622 - 3624 2021.12
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Association of Multiple Gene Polymorphisms Including Homozygous NUDT15 R139C With Thiopurine Intolerance During the Treatment of Acute Lymphoblastic Leukemia.
Kudo K, Sato T, Takahashi Y, Yuzawa K, Kobayashi A, Kamio T, Sasaki S, Shimada J, Otani K, Tusjimoto S, Kato M, Toki T, Terui K, Ito E
Journal of pediatric hematology/oncology 43 ( 8 ) e1173 - e1176 2021.11
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Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome.
Takashi Taga, Shiro Tanaka, Daisuke Hasegawa, Kiminori Terui, Tsutomu Toki, Shotaro Iwamoto, Hidefumi Hiramatsu, Takako Miyamura, Yoshiko Hashii, Hiroshi Moritake, Hideki Nakayama, Hiroyuki Takahashi, Akira Shimada, Tomohiko Taki, Etsuro Ito, Asahito Hama, Masafumi Ito, Katsuyoshi Koh, Daiichiro Hasegawa, Akiko M Saito, Souichi Adachi, Daisuke Tomizawa
Leukemia 35 ( 9 ) 2508 - 2516 2021.9
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Usefulness of functional splicing analysis to confirm precise disease pathogenesis in Diamond-Blackfan anemia caused by intronic variants in RPS19.
Satoru Takafuji, Takeshi Mori, Noriyuki Nishimura, Nobuyuki Yamamoto, Suguru Uemura, Kandai Nozu, Kiminori Terui, Tsutomu Toki, Etsuro Ito, Hideki Muramatsu, Yoshiyuki Takahashi, Masafumi Matsuo, Tomohiko Yamamura, Kazumoto Iijima
Pediatric hematology and oncology 38 ( 6 ) 515 - 527 2021.9
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BRAFV600E-positive precursors as molecular markers of bone marrow disease in LCH(和訳中)
工藤 耕, 土岐 力, 金崎 里香, 小林 明恵, 佐藤 知彦, 神尾 卓哉, 佐々木 伸也, 今村 勝, 今井 千速, 安藤 久美子, 角田 治美, 土居 岳彦, 川口 浩史, 入江 正寛, 笹原 洋二, 田村 彰広, 長谷川 大一郎, 板倉 陽介, 渡邉 健一郎, 深野 玲司, 坂本 謙一, 塩田 曜子, 加藤 元博, 工藤 寿子, 金兼 弘和, 伊藤 悦朗, 照井 君典
日本血液学会学術集会 83回 OS2 - 2 2021.9
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Predictive factors for the development of leukemia in patients with transient abnormal myelopoiesis and Down syndrome.
Genki Yamato, Takao Deguchi, Kiminori Terui, Tsutomu Toki, Tomoyuki Watanabe, Takahiro Imaizumi, Asahito Hama, Shotaro Iwamoto, Daisuke Hasegawa, Takahiro Ueda, Tomoko Yokosuka, Shiro Tanaka, Ryu Yanagisawa, Katsuyoshi Koh, Akiko M Saito, Keizo Horibe, Yasuhide Hayashi, Souichi Adachi, Shuki Mizutani, Takashi Taga, Etsuro Ito, Kenichiro Watanabe, Hideki Muramatsu
Leukemia 35 ( 5 ) 1480 - 1484 2021.5
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Reduced-intensity conditioning is effective for hematopoietic stem cell transplantation in young pediatric patients with Diamond-Blackfan anemia.
Shun Koyamaishi, Takuya Kamio, Akie Kobayashi, Tomohiko Sato, Ko Kudo, Shinya Sasaki, Rika Kanezaki, Daiichiro Hasegawa, Hideki Muramatsu, Yoshiyuki Takahashi, Yoji Sasahara, Hidefumi Hiramatsu, Harumi Kakuda, Miyuki Tanaka, Masataka Ishimura, Masanori Nishi, Akira Ishiguro, Hiromasa Yabe, Takeo Sarashina, Masaki Yamamoto, Yuki Yuza, Nobuyuki Hyakuna, Kenichi Yoshida, Hitoshi Kanno, Shouichi Ohga, Akira Ohara, Seiji Kojima, Satoru Miyano, Seishi Ogawa, Tsutomu Toki, Kiminori Terui, Etsuro Ito
Bone marrow transplantation 56 ( 5 ) 1013 - 1020 2021.5
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Correction: Reduced-intensity conditioning is effective for hematopoietic stem cell transplantation in young pediatric patients with Diamond-Blackfan anemia (Bone Marrow Transplantation, (2021), 56, 5, (1013-1020), 10.1038/s41409-020-01056-1)
Shun Koyamaishi, Takuya Kamio, Akie Kobayashi, Tomohiko Sato, Ko Kudo, Shinya Sasaki, Rika Kanezaki, Daiichiro Hasegawa, Hideki Muramatsu, Yoshiyuki Takahashi, Yoji Sasahara, Hidefumi Hiramatsu, Harumi Kakuda, Miyuki Tanaka, Masataka Ishimura, Masanori Nishi, Akira Ishiguro, Hiromasa Yabe, Takeo Sarashina, Masaki Yamamoto, Yuki Yuza, Nobuyuki Hyakuna, Kenichi Yoshida, Hitoshi Kanno, Shouichi Ohga, Akira Ohara, Seiji Kojima, Satoru Miyano, Seishi Ogawa, Tsutomu Toki, Kiminori Terui, Etsuro Ito
Bone Marrow Transplantation 56 ( 5 ) 1218 - 1219 2021.5
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Correction: Reduced-intensity conditioning is effective for hematopoietic stem cell transplantation in young pediatric patients with Diamond-Blackfan anemia.
Shun Koyamaishi, Takuya Kamio, Akie Kobayashi, Tomohiko Sato, Ko Kudo, Shinya Sasaki, Rika Kanezaki, Daiichiro Hasegawa, Hideki Muramatsu, Yoshiyuki Takahashi, Yoji Sasahara, Hidefumi Hiramatsu, Harumi Kakuda, Miyuki Tanaka, Masataka Ishimura, Masanori Nishi, Akira Ishiguro, Hiromasa Yabe, Takeo Sarashina, Masaki Yamamoto, Yuki Yuza, Nobuyuki Hyakuna, Kenichi Yoshida, Hitoshi Kanno, Shouichi Ohga, Akira Ohara, Seiji Kojima, Satoru Miyano, Seishi Ogawa, Tsutomu Toki, Kiminori Terui, Etsuro Ito
Bone marrow transplantation 56 ( 5 ) 1218 - 1219 2021.5
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Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation.
Yoko Nishinaka-Arai, Akira Niwa, Shiori Matsuo, Yasuhiro Kazuki, Yuwna Yakura, Takehiko Hiroma, Tsutomu Toki, Tetsushi Sakuma, Takashi Yamamoto, Etsuro Ito, Mitsuo Oshimura, Tatsutoshi Nakahata, Megumu K Saito
Haematologica 106 ( 2 ) 635 - 640 2021.2
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New insights into inherited bone marrow failure syndrome
ITO Etsuro, TOKI Tsutomu, KAMIO Takuya, TERUI Kiminori
Rinsho Ketsueki 62 ( 10 ) 1455 - 1464 2021
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Enzymatic Changes in Red Blood Cells of Diamond-Blackfan Anemia
Utsugisawa Taiju, Uchiyama Toshitaka, Toki Tsutomu, Shimojima-Yamamoto Keiko, Ohga Shouichi, Ito Etsuro, Kanno Hitoshi
The Tohoku Journal of Experimental Medicine 255 ( 1 ) 49 - 55 2021
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Outcome of colorectal cancer in Diamond-Blackfan syndrome with a ribosomal protein S19 mutation.
Kazuya Kimura, Kazuhiro Shimazu, Tsutomu Toki et al.
Clinical journal of gastroenterology 13 ( 6 ) 1173 - 1177 2020.12
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Clinical, cytogenetic, and molecular analyses of 17 neonates with transient abnormal myelopoiesis and nonconstitutional trisomy 21.
Kentaro Yuzawa, Kiminori Terui, Tsutomu Toki, Rika Kanezaki, Akie Kobayashi, Tomohiko Sato, Takuya Kamio, Ko Kudo, Shinya Sasaki, Mikiya Endo, Shuichi Ozono, Keiko Nomura, Etsuro Ito
Pediatric blood & cancer 67 ( 4 ) e28188 2020.2
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BRAFV600E-Positive Precursors as Molecular Markers of Bone Marrow Involvement in Pediatric Langerhans Cell Histiocytosis
Kudo Ko, Kanezaki Rika, Masaru Imamura, Imai Chihaya, Irie Masahiro, Sasahara Yoji, Ando Kumiko, Kakuda Harumi, Doi Takehiko, Kawaguchi Hiroshi, Kudo Kazuko, Kanegane Hirokazu, Kobayashi Akie, Sato Tomohiko, Kamio Takuya, Sasaki Shinya, Terui Kiminori, Toki Tsutomu, Ito Etsuro
PEDIATRIC BLOOD & CANCER 66 S47 2019.12
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Clinical and Molecular Cytogenetic Analysis of 15 Mosaic/Non-Down Syndrome Neonates With Transient Abnormal Myelopoiesis
Yuzawa Kentaro, Terui Kimnori, Toki Tsutomu, Kanezaki Rika, Kobayashi Akie, Sato Tomohiko, Kamio Takuya, Kudo Ko, Sasaki Shinya, Endo Mikiya, Ozono Shuichi, Ito Etsuro
PEDIATRIC BLOOD & CANCER 66 S35 2019.12
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HNRNPH1-MLLT10 Fusion in Childhood Acute Myeloid Leukemia with 5q Abnormalities; A Case Report
Kudo Ko, Kobayashi Akie, Sato Tomohiko, Kamio Takuya, Sasaki Shinya, Kanezaki Rika, Toki Tsutomu, Terui Kiminori, Ito Etsuro
PEDIATRIC BLOOD & CANCER 66 S20 - S21 2019.12
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小児における前駆B細胞急性リンパ芽球性白血病の再発例を対象とした網羅的遺伝子解析(Comprehensive genetic analyses of relapsed B-cell precursor acute lymphoblastic leukemia in children)
Kubo Kaori, Kudo Ko, Toki Tsutomu, Kanezaki Rika, Ikeda Fumika, Ito Tatsuya, Kobayashi Akie, Sato Tomohiko, Kamio Takuya, Sasaki Shinya, Terui Kiminori, Ito Etsuro
弘前医学 70 ( 1 ) 13 - 23 2019.11
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Highly sensitive detection of GATA1 mutations in patients with myeloid leukemia associated with Down syndrome by combining Sanger and targeted next generation sequencing.
Terui K, Toki T, Taga T, Iwamoto S, Miyamura T, Hasegawa D, Moritake H, Hama A, Nakashima K, Kanezaki R, Kudo K, Saito AM, Horibe K, Adachi S, Tomizawa D, Ito E
Genes, chromosomes & cancer 59 ( 3 ) 160 - 167 2019.10
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Integrated genetic and epigenetic analysis revealed heterogeneity of acute lymphoblastic leukemia in Down syndrome.
Yasuo Kubota, Kumiko Uryu, Tatsuya Ito, Masafumi Seki, Tomoko Kawai, Tomoya Isobe, Tadayuki Kumagai, Tsutomu Toki, Kenichi Yoshida, Hiromichi Suzuki, Keisuke Kataoka, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Kentaro Ohki, Nobutaka Kiyokawa, Jiro Kagawa, Satoru Miyano, Akira Oka, Yasuhide Hayashi, Seishi Ogawa, Kiminori Terui, Atsushi Sato, Kenichiro Hata, Etsuro Ito, Junko Takita
Cancer science 110 ( 10 ) 3358 - 3367 2019.9
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Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.
Atsushi Watanabe, Takeshi Inukai, Keiko Kagami, Masako Abe, Masatoshi Takagi, Takashi Fukushima, Hiroko Fukushima, Toru Nanmoku, Kiminori Terui, Tatsuya Ito, Tsutomu Toki, Etsuro Ito, Junya Fujimura, Hiroaki Goto, Mikiya Endo, Thomas Look, Mark Kamps, Masayoshi Minegishi, Junko Takita, Toshiya Inaba, Hiroyuki Takahashi, Akira Ohara, Daisuke Harama, Tamao Shinohara, Shinpei Somazu, Hiroko Oshiro, Koshi Akahane, Kumiko Goi, Kanji Sugita
Cancer Med 8 ( 11 ) 5274 - 5288 2019.7
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MYH7 mutation identified by next-generation sequencing in three infant siblings with bi-ventricular noncompaction presenting with restrictive hemodynamics: A report of three siblings with a severe phenotype and poor prognosis.
Fumitake Miura, Jun Shimada, Yosuke Kitagawa, Katsuki Otani, Takumi Sato, Tsutomu Toki, Toru Takahashi, Susumu Yonesaka, Hiroki Mizukami, Etsuro Ito
Journal of cardiology cases 19 ( 4 ) 140 - 143 2019.4
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5歳で顕性化して遺伝子診断した橈尺骨癒合症を伴うDBA男児
松岡 正樹, 羽賀 洋一, 高橋 浩之, 村松 秀城, 土岐 力, 照井 君典, 伊藤 悦朗, 小原 明
日本小児科学会雑誌 123 ( 2 ) 491 - 491 2019.2
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Comprehensive genetic analyses of relapsed B-cell precursor acute lymphoblastic leukemia in children
Kubo Kaori, Kudo Ko, Toki Tsutomu, Ito Etsuro, Ikeda Fumika, Ito Tatsuya, Kobayashi Akie, Sato Tomohiko, Kamio Takuya, Sasaki Shinya
Hirosaki Medical Journal 70 ( 1 ) 13 - 23 2019
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Effective response to azacitidine in a child with a second relapse of myeloid leukemia associated with Down syndrome after bone marrow transplantation.
S. Uemura, T. Mori, C. Nagano, S. Takafuji, N. Nishimura, T. Toki, K. Terui, E. Ito, K. Iijima
Pediatric blood & cancer 65 ( 12 ) e27414 - e27414 2018.12
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Two siblings with familial neuroblastoma with distinct clinical phenotypes harboring an ALK germline mutation.
Ko Kudo, Hiroo Ueno, Tomohiko Sato, Kaori Kubo, Rika Kanezaki, Akie Kobayashi, Takuya Kamio, Shinya Sasaki, Kiminori Terui, Akira Kurose, Kenichi Yoshida, Yusuke Shiozawa, Tsutomu Toki, Seishi Ogawa, Etsuro Ito
Genes, chromosomes & cancer 57 ( 12 ) 665 - 669 2018.10
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Effective response to azacitidine in a child with a second relapse of myeloid leukemia associated with Down syndrome after bone marrow transplantation.
Suguru Uemura, Takeshi Mori, China Nagano, Satoru Takafuji, Noriyuki Nishimura, Tsutomu Toki, Kiminori Terui, Etsuro Ito, Kazumoto Iijima
Pediatric blood & cancer 65 ( 12 ) e27414 2018.9
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De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.
Tsutomu Toki, Kenichi Yoshida, RuNan Wang, Sou Nakamura, Takanobu Maekawa, Kumiko Goi, Megumi C Katoh, Seiya Mizuno, Fumihiro Sugiyama, Rika Kanezaki, Tamayo Uechi, Yukari Nakajima, Yusuke Sato, Yusuke Okuno, Aiko Sato-Otsubo, Yusuke Shiozawa, Keisuke Kataoka, Yuichi Shiraishi, Masashi Sanada, Kenichi Chiba, Hiroko Tanaka, Kiminori Terui, Tomohiko Sato, Takuya Kamio, Hirotoshi Sakaguchi, Shouichi Ohga, Madoka Kuramitsu, Isao Hamaguchi, Akira Ohara, Hitoshi Kanno, Satoru Miyano, Seiji Kojima, Akira Ishiguro, Kanji Sugita, Naoya Kenmochi, Satoru Takahashi, Koji Eto, Seishi Ogawa, Etsuro Ito
American journal of human genetics 103 ( 3 ) 440 - 447 2018.9
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Atypical erythroblastosis in a patient with Diamond-Blackfan anemia who developed del(20q) myelodysplasia.
Sonoda M, Ishimura M, Ichimiya Y, Terashi E, Eguchi K, Sakai Y, Takada H, Hama A, Kanno H, Toki T, Ito E, Ohga S
International journal of hematology 108 ( 2 ) 228 - 231 2018.8
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Correction to: Atypical erythroblastosis in a patient with Diamond-Blackfan anemia who developed del(20q) myelodysplasia.
Motoshi Sonoda, Masataka Ishimura, Yuko Ichimiya, Eiko Terashi, Katsuhide Eguchi, Yasunari Sakai, Hidetoshi Takada, Asahito Hama, Hitoshi Kanno, Tsutomu Toki, Etsuro Ito, Shouichi Ohga
International journal of hematology 108 ( 2 ) 236 - 236 2018.8
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Diamond‐Blackfan貧血の診断的ターゲットおよびエクソームシーケンス解析
土岐力, 伊藤悦朗
小児科 59 ( 8 ) 1203 - 1212 2018.7
-
Diagnostic targets and exosome sequence analysis of Diamond-Blackfan anemia in Japan
TOKI Tsutomu, ITO Etsuro
Rinsho Ketsueki 59 ( 7 ) 945 - 952 2018
-
Purification of leukemic blast cells from blood smears using laser microdissection
Hidemasa Matsuo, Shuichi Shiga, Tsuyoshi Imai, Yasuhiko Kamikubo, Tsutomu Toki, Kiminori Terui, Etsuro Ito, Souichi Adachi
INTERNATIONAL JOURNAL OF HEMATOLOGY 106 ( 1 ) 55 - 59 2017.7
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Diagnostic challenge of Diamond-Blackfan anemia in mothers and children by whole-exome sequencing
Takuya Ichimura, Kenichi Yoshida, Yusuke Okuno, Toshiaki Yujiri, Kozo Nagai, Masanori Nishi, Yuichi Shiraishi, Hiroo Ueno, Tsutomu Toki, Kenichi Chiba, Hiroko Tanaka, Hideki Muramatsu, Toshiro Hara, Hitoshi Kanno, Seiji Kojima, Satoru Miyano, Etsuro Ito, Seishi Ogawa, Shouichi Ohga
INTERNATIONAL JOURNAL OF HEMATOLOGY 105 ( 4 ) 515 - 520 2017.4
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Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia
Fumika Ikeda, Kenichi Yoshida, Tsutomu Toki, Tamayo Uechi, Shiori Ishida, Yukari Nakajima, Yoji Sasahara, Yusuke Okuno, Rika Kanezaki, Kiminori Terui, Takuya Kamio, Akie Kobayashi, Takashi Fujita, Aiko Sato-Otsubo, Yuichi Shiraishi, Hiroko Tanaka, Kenichi Chiba, Hideki Muramatsu, Hitoshi Kanno, Shouichi Ohga, Akira Ohara, Seiji Kojima, Naoya Kenmochi, Satoru Miyano, Seishi Ogawa, Etsuro Ito
HAEMATOLOGICA 102 ( 3 ) e93 - e96 2017.3
-
感染を契機に診断に至ったRPL11の遺伝子変異陽性Diamond-Blackfan anemiaの11歳男児例(原著論文/症例報告)
新居 敏, 藤野 寿典, 赤澤 嶺, 田尻 雄二朗, 高野 良彦, 土岐 力, 他
小児科臨床 69 ( 8 ) 1416 - 1420 2016.8
-
Erythrocyte glutathione is a novel biomarker of Diamond-Blackfan anemia
Taiju Utsugisawa, Toshitaka Uchiyama, Tsutomu Toki, Hiromi Ogura, Takako Aoki, Isao Hamaguchi, Akira Ishiguro, Akira Ohara, Seiji Kojima, Shouichi Ohga, Etsuro Ito, Hitoshi Kanno
BLOOD CELLS MOLECULES AND DISEASES 59 31 - 36 2016.7
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Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities
Kimihiko Banno, Sayaka Omori, Katsuya Hirata, Nobutoshi Nawa, Natsuki Nakagawa, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Tetsushi Sakuma, Takashi Yamamoto, Tsutomu Toki, Etsuro Ito, Toshiyuki Yamamoto, Chikara Kokubu, Junji Takeda, Hidetoshi Taniguchi, Hitomi Arahori, Kazuko Wada, Yasuji Kitabatake, Keiichi Ozono
CELL REPORTS 15 ( 6 ) 1228 - 1241 2016.5
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ALDH2 polymorphism in patients with Diamond-Blackfan anemia in Japan
Fumika Ikeda, Tsutomu Toki, Rika Kanezaki, Kiminori Terui, Kenichi Yoshida, Hitoshi Kanno, Shouichi Ohga, Akira Ohara, Seiji Kojima, Seishi Ogawa, Etsuro Ito
INTERNATIONAL JOURNAL OF HEMATOLOGY 103 ( 1 ) 112 - 114 2016.1
-
Recent advances in inherited bone marrow failure syndrome research
ITO Etsuro, TOKI Tsutomu, TERUI Kiminori
Rinsho Ketsueki 57 ( 7 ) 882 - 890 2016
-
Transient myeloproliferative disorder with partial trisomy 21.
Takahide Takahashi, Akira Inoue, Junko Yoshimoto, Kiichiro Kanamitsu, Tomohiko Taki, Masahide Imada, Mutsuko Yamada, Shinsuke Ninomiya, Tsutomu Toki, Kiminori Terui, Etsuro Ito, Akira Shimada
Pediatric blood & cancer 62 ( 11 ) 2021 - 2024 2015.11
-
Preserved High Probability of Overall Survival with Significant Reduction of Chemotherapy for Myeloid Leukemia in Down Syndrome: A Nationwide Prospective Study in Japan
Takashi Taga, Tomoyuki Watanabe, Daisuke Tomizawa, Kazuko Kudo, Kiminori Terui, Hiroshi Moritake, Akitoshi Kinoshita, Shotaro Iwamoto, Hideki Nakayama, Hiroyuki Takahashi, Akira Shimada, Tomohiko Taki, Tsutomu Toki, Etsuro Ito, Hiroaki Goto, Katsuyoshi Koh, Akiko M. Saito, Keizo Horibe, Tatsutoshi Nakahata, Akio Tawa, Souichi Adachi
PEDIATRIC BLOOD & CANCER 63 ( 2 ) 248 - 254 2015.10
-
Transient Myeloproliferative Disorder With Partial Trisomy 21
Takahide Takahashi, Akira Inoue, Junko Yoshimoto, Kiichiro Kanamitsu, Tomohiko Taki, Masahide Imada, Mutsuko Yamada, Shinsuke Ninomiya, Tsutomu Toki, Kiminori Terui, Etsuro Ito, Akira Shimada
PEDIATRIC BLOOD & CANCER 62 ( 11 ) 2021 - 2024 2015.7
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Acute megakaryoblastic leukemia with acquired trisomy 21 and GATA1 mutations in phenotypically normal children
Rintaro Ono, Daisuke Hasegawa, Shinsuke Hirabayashi, Takahiro Kamiya, Kenichi Yoshida, Satoko Yonekawa, Chitose Ogawa, Ryota Hosoya, Tsutomu Toki, Kiminori Terui, Etsuro Ito, Atsushi Manabe
EUROPEAN JOURNAL OF PEDIATRICS 174 ( 4 ) 525 - 531 2015.4
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ダウン症候群に伴うTAM発症の分子機構
金崎 里香, 土岐 力, 伊藤 悦朗
日本産婦人科・新生児血液学会誌 25 49 - 54 2015
-
Molecular mechanisms underlying the pathology of Diamond-Blackfan anemia
TOKI Tsutomu, ITO Etsuro
Rinsho Ketsueki 56 ( 7 ) 867 - 876 2015
-
Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia
RuNan Wang, Kenichi Yoshida, Tsutomu Toki, Takafumi Sawada, Tamayo Uechi, Yusuke Okuno, Aiko Sato-Otsubo, Kazuko Kudo, Isamu Kamimaki, Rika Kanezaki, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Kiminori Terui, Tomohiko Sato, Yuji Iribe, Shouichi Ohga, Madoka Kuramitsu, Isao Hamaguchi, Akira Ohara, Junichi Hara, Kumiko Goi, Kousaku Matsubara, Kenichi Koike, Akira Ishiguro, Yasuhiro Okamoto, Kenichiro Watanabe, Hitoshi Kanno, Seiji Kojima, Satoru Miyano, Naoya Kenmochi, Seishi Ogawa, Etsuro Ito
BRITISH JOURNAL OF HAEMATOLOGY 168 ( 6 ) 854 - 864 2014.11
-
Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies
Yasuhiro Kazuki, Yuwna Yakura, Satoshi Abe, Mitsuhiko Osaki, Naoyo Kajitani, Kanako Kazuki, Shoko Takehara, Kazuhisa Honma, Hirofumi Suemori, Satoshi Yamazaki, Tetsushi Sakuma, Tsutomu Toki, Ritsuko Shimizu, Hiromitsu Nakauchi, Takashi Yamamoto, Mitsuo Oshimura
SCIENTIFIC REPORTS 4 6136 2014.8
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Gene Alterations Involving the CRLF2-JAK Pathway and Recurrent Gene Deletions in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan
Isamu Hanada, Kiminori Terui, Fumika Ikeda, Tsutomu Toki, Rika Kanezaki, Tomohiko Sato, Takuya Kamio, Ko Kudo, Shinya Sasaki, Yoshihiro Takahashi, Yasuhide Hayashi, Takeshi Inukai, Seiji Kojima, Kenichi Koike, Yoshiyuki Kosaka, Masao Kobayashi, Masue Imaizumi, Tetsuo Mitsui, Hiroki Hori, Junichi Hara, Keizo Horibe, Jun-ichi Nagai, Hiroaki Goto, Etsuro Ito
GENES CHROMOSOMES & CANCER 53 ( 11 ) 902 - 910 2014.7
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Novel in-frame deletion of <i>GATA1</i> observed in pediatric acute megakaryoblastic leukemia without down syndrome
Wang RuNan, Kanezaki Rika, Toki Tsutomu, Terui Kiminori, Sasaki Shinya, Kudo Ko, Kamio Takuya, Sato Tomohiko, Ikeda Fumika, Araki Ryo, Ochiai Hidetoshi, Ito Etsuro
Hirosaki Medical Journal 65 ( 2-4 ) 227 - 237 2014
-
特集 造血器腫瘍のゲノム解析 ４.Down syndrome associated myeloid disorders
伊藤悦朗, 土岐力
血液フロンティア 24 ( 1 ) 47 - 53 2013.12
-
The landscape of somatic mutations in Down syndrome-related myeloid disorders
Kenichi Yoshida, Tsutomu Toki, Yusuke Okuno, Rika Kanezaki, Yuichi Shiraishi, Aiko Sato-Otsubo, Masashi Sanada, Myoung-ja Park, Kiminori Terui, Hiromichi Suzuki, Ayana Kon, Yasunobu Nagata, Yusuke Sato, RuNan Wang, Norio Shiba, Kenichi Chiba, Hiroko Tanaka, Asahito Hama, Hideki Muramatsu, Daisuke Hasegawa, Kazuhiro Nakamura, Hirokazu Kanegane, Keiko Tsukamoto, Souichi Adachi, Kiyoshi Kawakami, Koji Kato, Ryosei Nishimura, Shai Izraeli, Yasuhide Hayashi, Satoru Miyano, Seiji Kojima, Etsuro Ito, Seishi Ogawa
NATURE GENETICS 45 ( 11 ) 1293 - + 2013.11
-
Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome
Satoshi Saida, Ken-ichiro Watanabe, Aiko Sato-Otsubo, Kiminori Terui, Kenichi Yoshida, Yusuke Okuno, Tsutomu Toki, RuNan Wang, Yuichi Shiraishi, Satoru Miyano, Itaru Kato, Tatsuya Morishima, Hisanori Fujino, Katsutsugu Umeda, Hidefumi Hiramatsu, Souichi Adachi, Etsuro Ito, Seishi Ogawa, Mamoru Ito, Tatsutoshi Nakahata, Toshio Heike
BLOOD 121 ( 21 ) 4377 - 4387 2013.5
-
Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome
Tsutomu Toki, Rika Kanezaki, Eri Kobayashi, Hiroshi Kaneko, Mikiko Suzuki, RuNan Wang, Kiminori Terui, Hirokazu Kanegane, Miho Maeda, Mikiya Endo, Tatsuki Mizuochi, Souichi Adachi, Yasuhide Hayashi, Masayuki Yamamoto, Ritsuko Shimizu, Etsuro Ito
Blood 121 ( 16 ) 3181 - 3184 2013.4
-
Down syndrome associated myeloid disorders
土岐 力
血液フロンティア 24 47 - 53 2013
-
新生児科医のためのTAM診療ガイドラインTAM発症の分子機構
照井 君典, 土岐 力
日本周産期・新生児医学会雑誌 49 20 - 22 2013
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ダウン症候群関連急性リンパ性白血病におけるJAK2およびCRLF2遺伝子異常
照井 君典, 土岐 力
日本小児血液・がん学会雑誌 50 11 - 14 2013
-
A Novel Mutation of Ribosomal Protein S10 Gene in a Japanese Patient With Diamond-Blackfan Anemia
Makoto Yazaki, Michi Kamei, Yasuhiko Ito, Yuki Konno, RuNan Wang, Tsutomu Toki, Etsuro Ito
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 34 ( 4 ) 293 - 295 2012.5
-
[Transient myeloproliferative disorder in Down syndrome].
Ito E, Toki T
Nihon rinsho. Japanese journal of clinical medicine 70 Suppl 2 687 - 91 2012.4
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Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia
Takashi Yokoyama, Tsutomu Toki, Yoshihiro Aoki, Rika Kanezaki, Myoung-ja Park, Yohei Kanno, Tomoko Takahara, Yukari Yamazaki, Etsuro Ito, Yasuhide Hayashi, Takuro Nakamura
BLOOD 119 ( 11 ) 2608 - 2611 2012.3
-
Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia
Madoka Kuramitsu, Aiko Sato-Otsubo, Tomohiro Morio, Masatoshi Takagi, Tsutomu Toki, Kiminori Terui, RuNan Wang, Hitoshi Kanno, Shouichi Ohga, Akira Ohara, Seiji Kojima, Toshiyuki Kitoh, Kumiko Goi, Kazuko Kudo, Tadashi Matsubayashi, Nobuo Mizue, Michio Ozeki, Atsuko Masumi, Haruka Momose, Kazuya Takizawa, Takuo Mizukami, Kazunari Yamaguchi, Seishi Ogawa, Etsuro Ito, Isao Hamaguchi
BLOOD 119 ( 10 ) 2376 - 2384 2012.3
-
Down症に伴う骨髄増殖症
土岐 力
日本臨床 70 687 - 91 2012
-
Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages
Nobuhiko Harada, Masaya Kanayama, Atsushi Maruyama, Aruto Yoshida, Kyoko Tazumi, Tomonori Hosoya, Junsei Mimura, Tsutomu Toki, Jonathan M. Maher, Masayuki Yamamoto, Ken Itoh
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 508 ( 1 ) 101 - 109 2011.4
-
一過性骨髄異常増殖症(TAM)発症の分子機構
土岐 力
日本小児血液学会雑誌 25 171 - 8 2011
-
Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia
Rika Kanezaki, Tsutomu Toki, Kiminori Terui, Gang Xu, RuNan Wang, Akira Shimada, Asahito Hama, Hirokazu Kanegane, Kiyoshi Kawakami, Mikiya Endo, Daisuke Hasegawa, Kazuhiro Kogawa, Souichi Adachi, Yasuhiko Ikeda, Shotaro Iwamoto, Takashi Taga, Yoshiyuki Kosaka, Seiji Kojima, Yasuhide Hayashi, Etsuro Ito
BLOOD 116 ( 22 ) 4631 - 4638 2010.11
-
Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mutations recurrently identified in acute myeloid leukemia
Akane Tsujimura, Hitoshi Kiyoi, Yukimasa Shiotsu, Yuichi Ishikawa, Yumiko Mori, Hiroshi Ishida, Tsutomu Toki, Etsuro Ito, Tomoki Naoe
INTERNATIONAL JOURNAL OF HEMATOLOGY 92 ( 4 ) 624 - 633 2010.11
-
Molecular pathogenesis in Diamond-Blackfan anemia
Etsuro Ito, Yuki Konno, Tsutomu Toki, Kiminori Terui
INTERNATIONAL JOURNAL OF HEMATOLOGY 92 ( 3 ) 413 - 418 2010.10
-
典型例とは異なる緩徐な臨床経過を示し、リボソームタンパク遺伝子RPL11の変異の検出により診断したDiamond-Blackfan貧血の1例
佐野 弘純, 朴 明子, 外松 学, 今野 友貴, 土岐 力, 伊藤 悦朗, 林 泰秀
日本小児血液学会雑誌 24 ( 4 ) 225 - 228 2010.8
-
Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia
Yuki Konno, Tsutomu Toki, Satoru Tandai, Gang Xu, RuNan Wang, Kiminori Terui, Shouichi Ohga, Toshiro Hara, Asahito Hama, Seiji Kojima, Daiichiro Hasegawa, Yoshiyuki Kosaka, Ryu Yanagisawa, Kenichi Koike, Rie Kanai, Tsuyoshi Imai, Teruaki Hongo, Myoung-Ja Park, Kanji Sugita, Etsuro Ito
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 95 ( 8 ) 1293 - 1299 2010.8
-
Exposure to a MRI-Type High-Strength Static Magnetic Field Stimulates Megakaryocytic/Erythroid Hematopoiesis in CD34(+) Cells From Human Placental and Umbilical Cord Blood
Satoru Monzen, Kenji Takahashi, Tsutomu Toki, Etsuro Ito, Tomonori Sakurai, Junji Miyakoshi, Ikuo Kashiwakura
BIOELECTROMAGNETICS 30 ( 4 ) 280 - 285 2009.5
-
小児科領域の血液疾患 一過性骨髄増殖性疾患
土岐 力, 照井 君典
日本検査血液学会雑誌 10 457 - 464 2009
-
一過性骨髄増殖症.小児疾患診療のための病態生理
土岐 力, 照井 君典
小児内科増刊号 41 1183 - 1186 2009
-
一過性骨髄増殖症
土岐 力
小児疾患診療のための病態生理小児内科増刊号 41 1183 - 1186 2009
-
The key role of stem cell factor/KIT signaling in the proliferation of blast cells from Down syndrome-related leukemia
土岐 力
Leukemia 23 ( 1 ) 95 - 103 2009
-
Construction of an expression system for aqualysin I in Escherichia coli that gives a markedly improved yield of the enzyme protein
Masayoshi Sakaguchi, Keisuke Niimiya, Makoto Takezawa, Tsutomu Toki, Yasusato Sugahara, Masao Kawakita
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 72 ( 8 ) 2012 - 2018 2008.8
-
Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome
Tomohiko Sato, Tsutomu Toki, Rika Kanezaki, Gang Xu, Kiminori Terui, Hirokazu Kanegane, Masayoshi Miura, Souichi Adachi, Masahiro Migita, Shingo Morinaga, Takahide Nakano, Mikiya Endo, Seiji Kojima, Hitoshi Kiyoi, Hiroyuki Mano, Etsuro Ito
BRITISH JOURNAL OF HAEMATOLOGY 141 ( 5 ) 681 - 688 2008.6
-
Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia
Akira Ishikawa, Hidemi Yoshida, Norifumi Metoki, Tsutomu Toki, Tadaatsu Imaizumi, Tomoh Matsumiya, Koji Yamashita, Kageaki Taima, Kei Satoh
NEUROSCIENCE RESEARCH 59 ( 4 ) 406 - 412 2007.12
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Correction of immunodeficiency associated with NEMO mutation by umbilical cord blood transplantation using a reduced-intensity conditioning regimen.
Tono C, Takahashi Y, Terui K, Sasaki S, Kamio T, Tandai S, Sato T, Kudo K, Toki T, Tachibana N, Yoshioka T, Nakahata T, Morio T, Nishikomori R, Ito E.
Bone Marrow Transplantation 39 ( 12 ) 801 - 804 2007.4
-
[The molecular mechanism of leukemogenesis in Down syndrome-related acute megakaryocytic leukemia].
Ito E, Toki T
Nihon rinsho. Japanese journal of clinical medicine 65 Suppl 1 136 - 140 2007.1
-
Development of acute megakaryoblastic leukemia from a minor clone in a Down syndrome patient with clinically overt transient myeloproliferative disorder
Gang Xu, Koji Kato, Tsutomu Toki, Yoshihiro Takahashi, Kiminori Terui, Etsuro Ito
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 28 ( 10 ) 696 - 698 2006.10
-
Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome.
Xu G, Kanezaki R, Toki T, Watanabe S, Takahashi Y, Terui K, Kitabayashi I, Ito E.
Leukemia 20 ( 6 ) 1002 - 1008 2006.6
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Cloning and Characterization of the Novel Chimeric Gene p53/FXR2 in the Acute Megakaryoblastic Leukemia Cell Line CMK11-5
Kanezaki Rika, Toki Tsutomu, Xu Gang, Narayanan Ramswamy, Ito Etsuro
The Tohoku Journal of Experimental Medicine 209 ( 3 ) 169 - 180 2006
-
JAK2 Val617Phe activating tyrosine kinase mutation in juvenile myelomonocytic leukemia.
Tono C, Xu G, Toki T, Takahashi Y, Sasaki S, Terui K, Ito E.
Leukemia 19 ( 10 ) 1843 - 1844 2005.10
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The proto-oncogene ERG in megakaryoblastic leukemias
L Rainis, T Toki, JE Pimanda, E Rosenthal, K Machol, S Strehl, B Gottgens, E Ito, S Izraeli
CANCER RESEARCH 65 ( 17 ) 7596 - 7602 2005.9
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Roxithromycin is an inhibitor of human coronary artery smooth muscle cells proliferation: a potential ability to prevent coronary heart disease
H Tomita, T Osanai, T Toki, N Maeda, R Murakami, ZN Chen, H Yamabe, H Osawa, M Yasujima, K Okumura
ATHEROSCLEROSIS 182 ( 1 ) 87 - 95 2005.9
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Troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibit shear-induced coupling factor 6 release in endothelial cells
H Tomita, T Osanai, T Toki, S Sasaki, N Maeda, R Murakami, K Magota, M Yasujima, K Okumura
CARDIOVASCULAR RESEARCH 67 ( 1 ) 134 - 141 2005.7
-
KCNJ2 mutation in intractable ventricular arrhythmia with Andersen's syndrome.
Takahashi T, Tandai S, Toki T, Sato T, Eto S, Sato A, Ueda T, Sato S, Ichinose K, Ito E, Yonesaka S
Pediatrics international : official journal of the Japan Pediatric Society 47 ( 2 ) 220 - 223 2005.4
-
Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment
T Toki, F Katsuoka, F Kanezaki, G Xu, H Kurotaki, JY Sun, T Kamio, S Watanabe, S Tandai, K Terui, S Yagihashi, N Komatsu, K Igarashi, M Yamamoto, E Ito
BLOOD 105 ( 8 ) 3100 - 3108 2005.4
-
The GATA1 mutation in an adult patient with acute megakaryoblastic leukemia not accompanying Down syndrome.
Harigae H, Xu G, Sugawara T, Ishikawa I, Toki T, Ito E
Blood 103 ( 8 ) 3242 - 3243 2004.4
-
21q11-21領域からの一過性骨髄異常増殖症の原因遺伝子単離の試み
石崎典子, 金崎里香, 土岐力, 伊藤悦朗
弘前医学 55 ( 3-4 ) 83 - 94 2004.3
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Fetal origin of the GATA1 mutation in identical twins with transient myeloproliferative disorder and acute megakaryoblastic leukemia accompanying Down syndrome.
Shimada A, Xu G, Toki T, Kimura H, Hayashi Y, Ito E
Blood 103 ( 1 ) 366 2004.1
-
Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients
Tomomi Uyeda, Toru Takahashi, Shuji Eto, Takumi Sato, Gang Xu, Rika Kanezaki, Tsutomu Toki, Susumu Yonesaka, Etsuro Ito
Journal of Human Genetics 49 ( 8 ) 404 - 407 2004
-
A trial of isolating the novel genes on 21q11-21 to elucidate the gene responsible for transient abnormal myelopoiesis
Ishizaki Noriko, Kanezaki Rika, Toki Tsutomu, Ito Etsuro
Hirosaki Medical Journal 55 ( 3-4 ) 83 - 94 2004
-
B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs.
Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, Ikebe D, Igarashi K, Ito E
Blood 102 ( 9 ) 3317 - 3322 2003.11
-
Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome
G Xu, M Nagano, R Kanezaki, T Toki, Y Hayashi, T Taketani, T Taki, T Mitui, K Koike, K Kato, M Imaizumi, Sekine, I, Y Ikeda, R Hanada, M Sako, K Kudo, S Kojima, O Ohneda, M Yamamoto, E Ito
BLOOD 102 ( 8 ) 2960 - 2968 2003.10
-
Glycogen synthase kinase-3 beta phosphorylates synphilin-1 in vitro
K Tanji, T Toki, W Tamo, T Imaizumi, T Matsumiya, F Mori, H Takahashi, K Satoh, K Wakabayashi
NEUROPATHOLOGY 23 ( 3 ) 199 - 202 2003.9
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B Cell Specific Transcription Factor BACH2 Negatively Regulates Expression of BCL-2 Related A1 Gene
TANDAI Satoru, SATO Hideko, KANEZAKI Rika, TOKI Tsutomu, IGARASHI Kazuhiko, ITO Etsuro
The Hirosaki medical journal 54 ( 1 ) 8 - 20 2002
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Transcription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoform.
R Kanezaki, T Toki, M Yokoyama, K Yomogida, K Sugiyama, M Yamamoto, K Igarashi, E Ito
The Journal of biological chemistry 276 ( 10 ) 7278 - 7284 2001.3
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Desferrioxamine, an iron chelator, upregulates cyclooxygenase-2 expression and prostaglandin production in a human macrophage cell line.
K Tanji, T Imaizumi, T Matsumiya, H Itaya, K Fujimoto, X Cui, T Toki, E Ito, H Yoshida, K Wakabayashi, K Satoh
Biochimica et biophysica acta 1530 ( 2-3 ) 227 - 235 2001.2
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Identification of the Target Genes for B Cell Specific Transcription Factor BACH2
SATO Hideko, SASAKI Shinya, KANEZAKI Rika, TOKI Tsutomu, ITO Etsuro
The Hirosaki medical journal 53 ( 2 ) 73 - 81 2001
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Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin.
K Terui, Y Takahashi, J Kitazawa, T Toki, M Yokoyama, E Ito
The Tohoku journal of experimental medicine 192 ( 4 ) 259 - 273 2000.12
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Functional characterization of the two alternative promoters of human p45 NF-E2 gene.
T Toki, K Arai, K Terui, N Komatsu, M Yokoyama, F Katsuoka, M Yamamoto, E Ito
Experimental hematology 28 ( 10 ) 1113 - 1119 2000.10
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Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15.
S Sasaki, E Ito, T Toki, T Maekawa, R Kanezaki, T Umenai, A Muto, H Nagai, T Kinoshita, M Yamamoto, J Inazawa, M M Taketo, T Nakahata, K Igarashi, M Yokoyama
Oncogene 19 ( 33 ) 3739 - 3749 2000.8
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Expression of Transcription Factors during Megakaryocytic Differentiation of CD34+ Cells from Human Cord Blood Induced by Thrombopoietin
Terui Kiminori, Takahashi Yoshihiro, Kitazawa Junichi, Toki Tsutomu, Yokoyama Masaru, Ito Etsuro
The Tohoku Journal of Experimental Medicine 192 ( 4 ) 259 - 273 2000
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Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3.
A Kobayashi, E Ito, T Toki, K Kogame, S Takahashi, K Igarashi, N Hayashi, M Yamamoto
The Journal of biological chemistry 274 ( 10 ) 6443 - 6452 1999.3
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Erythroid accelerating factor detected in serum from rats with drug induced hemolysis.
M Kasai, M Yokoyama, T Toki, H Maruyama, K Satoh, E Itoh
The Tohoku journal of experimental medicine 186 ( 4 ) 279 - 289 1998.12
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Progression from myelodysplastic syndrome with monosomy 7 to acute monoblastic leukemia with MLL gene rearrangement.
J Kitazawa, T Umenai, E Ito, K Arai, H Otomo, T Toki, M Seto, R Ueda, M Yokoyama
International journal of hematology 67 ( 1 ) 23 - 26 1998.1
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Structure and chromosome mapping of the human small maf-genes MAFG and MAFK.
T Iwata, K Kogame, T Toki, M Yokoyama, M Yamamoto, E Ito
Cytogenetics and cell genetics 82 ( 1-2 ) 88 - 90 1998
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Erythroid Accelerating Factor Detected in Serum from Rats with Drug Induced Hemolysis.
Kasai Mikio, Yokoyama Masaru, Toki Tsutomu, Maruyama Hidekazu, Satoh Kei, Itoh Etsuro
The Tohoku Journal of Experimental Medicine 186 ( 4 ) 279 - 289 1998
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Study on Prognostic Factor in the Children with Aplastic Anemia
KAIZUKA Michiko, INOUE Sinjo R., TOKI Tsutomu, et al.
11 ( 2 ) 84 - 87 1997.4
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Study on Prognosis and Prognostic Factor in Children with Aplastic Anemia, Experienced for Past 3 Decades
KAIZUKA Michiko, INOUE Sinjo R., TOKI Tsutomu, ITO Etsuro, YOKOYAMA Masaru
11 ( 2 ) 79 - 83 1997.4
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Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif.
T Toki, J Itoh, J Kitazawa, K Arai, K Hatakeyama, J Akasaka, K Igarashi, N Nomura, M Yokoyama, M Yamamoto, E Ito
Oncogene 14 ( 16 ) 1901 - 1910 1997.4
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Study on Prognostic Factor in the Children with Aplastic Anemia.
KAIZUKA Michiko, INOUE Sinjo R., TOKI Tsutomu, ITO Etsuro, YOKOYAMA Masaru
The Japanese Journal of Pediatric Hematology 11 ( 2 ) 84 - 87 1997
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Study on Prognosis and Prognostic Factor in Children with Aplastic Anemia, Experienced for Past 3 Decades.
KAIZUKA Michiko, INOUE Sinjo R., TOKI Tsutomu, ITO Etsuro, YOKOYAMA Masaru
The Japanese Journal of Pediatric Hematology 11 ( 2 ) 79 - 83 1997
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Expression of erythroid-specific genes in megakaryoblastic disorders.
E Ito, M Kasai, T Toki, K Arai, M Yokoyama
Leukemia & lymphoma 23 ( 5-6 ) 545 - 550 1996.11
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Analysis of Clinical Characteristics on Infantile Leukemia
ARAI Koji, ITO Etsuro, TOKI Tsutomu, et al.
The Japanese Journal of Pediatric Hematology 10 ( 5 ) 344 - 350 1996.10
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Abundant expression of erythroid transcription factor P45 NF-E2 mRNA in human peripheral granurocytes.
T Toki, J Itoh, K Arai, J Kitazawa, M Yokoyama, K Igarashi, M Yamamoto, E Ito
Biochemical and biophysical research communications 219 ( 3 ) 760 - 765 1996.2
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Analysis of Clinical Characteristics on Infantile Leukemia.
ARAI Koji, ITO Etsuro, TOKI Tsutomu, TERUI Kiminori, ANZAI Yukiko, OKA Toshiaki, ISHIKAWA Yorikazu, KUDO Toru, TAKEDA Takeo, TACHIBANA Naoki, TAKANO Nagakuni, WATANABE Arata, YOKOYAMA Shinkichi, IMAIZUMI Masue, KIKUTA Atsushi, TANAKA Atsushi, YOKOYAMA Masaru
The Japanese Journal of Pediatric Hematology 10 ( 5 ) 344 - 350 1996
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Erythroid Transcription Factors in Hematopoietic Cells.
ITO Etsuro, TOKI Tsutomu
The Japanese Journal of Pediatric Hematology 10 ( 1 ) 8 - 17 1996
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Anemia in Children with Neurological Diseases - Influence of Antiepileptic Drugs -
Mutsuko Shiotani, Norio Onodera, Tsutomu Toki, et al.
Hirosaki Medical Journal 46 254 - 259 1995.12
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Expression of erythroid-specific genes in acute megakaryoblastic leukaemia and transient myeloproliferative disorder in Down's syndrome.
E Ito, M Kasai, Y Hayashi, T Toki, et al
British journal of haematology 90 ( 3 ) 607 - 614 1995.7
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Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis.
E Ito, T Toki, H Ishihara, et al.
Nature 362 ( 6419 ) 466 - 468 1993.4
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Expression of a lineage specific transcriptional factor GATA-1 in leukaemic blasts from patients with infantile leukaemia.
E Ito, T Toki, K Arai, K Kawauchi, H Tsuda, M Yokoyama
British journal of haematology 80 ( 4 ) 561 - 563 1992.4
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The Alteration of Intracellular Enzyme Activities during Stimulation on Erythropoiesis. In vivo and in vitro Studies
Tsutomu Toki, Masaru Yokoyama
The Japanese Journal of Pediatric Hematology 5 ( 2 ) 145 - 150 1991.5
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The Alteration of Intracellular Enzyme Activities during Stimulation on Erythropoiesis. In vivo and in vitro Studies.
TOKI Tsutomu, YOKOYAMA Masaru
The Japanese Journal of Pediatric Hematology 5 ( 2 ) 145 - 150 1991
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The frequency of platelet count abnormality among junior high school students and quantitative, qualiative changes of platelets during treatment for adolescent iron deficiency anemia.
Yoshimasa Suto, Taketora Echizenya, Hiroyuki Kasetani, et al.
The Japanese Journal of Pediatric Hematology 4 ( 4 ) 342 - 347 1990.4
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The frequency of platelet count abnormality among junior high school students and quantitative, qualiative changes of platelets during treatment for adolescent iron deficiency anemia.
SUTO Yoshimasa, ECHIZENYA Taketora, KASETANI Hiroyuki, ARAI Kouji, TOKI Tsutomu, KAWAUCHI Kyouichi, SATO Yuichi, YOKOYAMA Masaru
The Japanese Journal of Pediatric Hematology 4 ( 4 ) 342 - 347 1990
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Severe Aplastic Anemia Successfully Treated with Cyclosporin A and Prednisolone
Ryousuke Ito, Kyoichi Kawauchi, Tsutomu Toki, et al.
The Japanese Journal of Clinical Hematology 30 ( 12 ) 2157 - 2162 1989.12
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The Effect of Hormones on Erythropoiesis
Hiroyuki Kasetani, Tsutomu Toki, Masaru Yokoyama
The Japanese Journal of Pediatric Hematology 3 ( 4 ) 325 - 332 1989.4
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The Alteration of Erythrocyte-GOT Activity and Erythropoietic Status in Various Blood Diseases
Tsutomu Toki, Ryosuke Ito, Hiroyuki Kasetani, et al.
The Japanese Journal of Pediatric Hematology 2 325 - 330 1989.1
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Severe Aplastic Anemia Successfully Treated with Cyclosporin A and Prednisolone
ITO Ryosuke, KAWAUCHI Kyoichi, TOKI Tsutomu, KASAI Mikio, ARAI Koji, SAITO Tosimitu, MIYANO Takakazu, SATO Yuichi, YOKOYAMA Masaru
Rinsho Ketsueki 30 ( 12 ) 2157 - 2162 1989
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The Alteration of Intracellular Cyclic Nucleotides Levels during Stimulation on Erythropoiesis
TOKI Tsutomu, KASETANI Hiroyuki, ARAI Kouji, YOKOYAMA Masaru
The Japanese Journal of Pediatric Hematology 3 ( 4 ) 345 - 350 1989
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The Effect of Hormones on Erythropoiesis
KASETANI Hiroyuki, TOKI Tsutomu, YOKOYAMA Masaru
The Japanese Journal of Pediatric Hematology 3 ( 4 ) 325 - 332 1989