論文 - 伊東 健
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Role of the Keap1/Nrf2 pathway in neurodegenerative diseases.
Hiromi Yamazaki, Kunikazu Tanji, Koichi Wakabayashi, Shin Matsuura, Ken Itoh
Pathology international 65 ( 5 ) 210 - 219 2015年05月
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Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer.
Momoko Kimura, Tae Yamamoto, Jianyong Zhang, Ken Itoh, Motoki Kyo, Terue Kamiya, Hiroyuki Aburatani, Fumiki Katsuoka, Hirofumi Kurokawa, Toshiyuki Tanaka, Hozumi Motohashi, Masayuki Yamamoto
The Journal of biological chemistry 290 ( 17 ) 10644 - 10644 2015年04月
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Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria.
Ken Itoh, Peng Ye, Tomoh Matsumiya, Kunikazu Tanji, Taku Ozaki
Journal of clinical biochemistry and nutrition 56 ( 2 ) 91 - 97 2015年03月
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Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding.
Atsushi Maruyama, Junsei Mimura, Ken Itoh
Nucleic acids research 42 ( 22 ) 13599 - 13614 2014年12月
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Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition.
Peng Ye, Junsei Mimura, Tomomi Okada, Hideyo Sato, Tao Liu, Atsushi Maruyama, Chikara Ohyama, Ken Itoh
Molecular and cellular biology 34 ( 18 ) 3421 - 3434 2014年09月
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Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.
Kunikazu Tanji, Yasuo Miki, Taku Ozaki, Atsushi Maruyama, Hidemi Yoshida, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi
Acta neuropathologica communications 2 50 - 50 2014年05月
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Carbocisteine reduces virus-induced pulmonary inflammation in mice exposed to cigarette smoke.
Yuichi Yageta, Yukio Ishii, Yuko Morishima, Satoshi Ano, Shigeo Ohtsuka, Masashi Matsuyama, Kaoru Takeuchi, Ken Itoh, Masayuki Yamamoto, Nobuyuki Hizawa
American journal of respiratory cell and molecular biology 50 ( 5 ) 963 - 973 2014年05月
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Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.
Pengfei Meng et al.
Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells. 75 ( 2 ) 94 - 102 2013年02月
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Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases.
Kunikazu Tanji et al.
J Neuropathol Exp Neurol 75 ( 2 ) 94 - 102 2013年01月
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Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation.
Nobuhiko Harada et al
Free Radic Biol Med 53 ( 12 ) 2256 - 2262 2012年10月
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Methylation of the KEAP1 gene promoter region in human colorectal cancer
Hanada N. et al.
BMC cancer 12 ( 66 ) 2012年02月
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Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers
Yamadori T. et al.
Oncogene 2012年01月
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Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes.
Mimura J. et al.
Journal of Biochemistry 150 ( 2 ) 209 - 217 2011年08月
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The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response
Maruyama A. et al.
Biochemical Journal 436 ( 2 ) 387 - 397 2011年06月
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Role of Nrf2 in host defense against influenza virus in cigarette smoke-exposed mice
Yageta Y. et al.
Journal of Virology 4679 ( 4690 ) 2011年05月
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Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducers
Hirotsu Y. et al.
Genes to Cells 16 ( 4 ) 406 - 415 2011年04月
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Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages
Harada N. et al.
Archive of Biochemistry and Biophysics 508 ( 1 ) 101 - 109 2011年04月
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Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation
Yoshida H. et al.
Neuroscience Research 69 ( 4 ) 291 - 298 2011年04月
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Discovery of the negative regulator of Nrf2, Keap1: a historical overview
Itoh K.et al.
Antioxidant redox signaling 13 ( 11 ) 2010年12月
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Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene
Becks L. et al.
BMC cancer 10 540 2010年10月